Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a bac-based DNA library: application to the detection of mycobacteria

ABSTRACT

A method for isolating a polynucleotide of interest that is present in the genome of a first mycobacterium strain and/or is expressed by the first mycobacterium strain, where the polynucleotide of interest is also absent or altered in the genome of a second mycobacterium strain and/or is not expressed in the second mycobacterium. The method includes (a) contacting the genomic DNA of the first mycobacterium strain under hybridizing conditions with the DNA of a least one clone that belongs to a bacterial artificial chromosome (BAC) genomic DNA library of the second mycobacterium strain, and (b) isolating the polynucleotide of interest that does not form a hybrid with the DNA of the second mycobacterium strain. This invention further pertains to a  Mycobacterium tuberculosis  strain H37Rv genomic DNA library, as well as a  Mycobactetium bovis  BCG strain Pasteur genomic DNA library, and the recombinant BAC vectors that belong to those genomic DNA libraries. This invention also relates to mycobacterial nucleic acids, and methods and kits for using these nucleic acids to detect mycobacteria in a biological sample.

This is a division of application Ser. No. 09/060,756, filed Apr. 16, 1998 now U.S. Pat. No. 6,183,957 which is Feb. 6, 2000 incorporated herein by reference.

I. BACKGROUND OF THE INVENTION

The present invention pertains to a method for isolating a polynucleotide of interest that is present in the genome of a mycobacterium strain and/or is expressed by said mycobacterium strain and that is absent or altered in the genome of a different mycobacterium strain and/or is not expressed in said different mycobacterium strain, said method comprising the use of at least one clone belonging to a genomic DNA library of a given mycobaterium strain, said DNA library being cloned in a bacterial artificial chromosome (BAC). The invention concerns also polynucleotides identified by the above method, as well as detection methods for mycobacteria, particularly Mycobacterium tuberculosis, and kits using said polynucleotides as primers or probes. Finally, the invention deals with BAC-based mycobacterium DNA libraries used in the method according to the invention and particularly BAC-based Mycobacterium tuberculosis and Mycobacterium bovis BCG DNA libraries.

Radical measures are required to prevent the grim predictions of the World Health Organisation for the evolution of the global tuberculosis epidemic in the next century becoming a tragic reality. The powerfill combination of genomics and bioinformatics is providing a wealth of information about the etiologic agent, Mycobacterium tuberculosis, that will facilitate the conception and development of new therapies. The start point for genome sequencing was the integrated map of the 4.4 Mb circular chromosome of the widely-used, virulent reference strain, M. tuberculosis H37Rv and appropriate cosmids were subjected to systematic shotgun sequence analysis at the Sanger Centre.

Cosmid clones (Balasubramanian et al., 1996; Pavelka et al., 1996) have played a crucial role in the M. tuberculosis H37Rv genome sequencing project. However, problems such as under-representation of certain regions of the chromosome, unstable inserts and the relatively small insert size complicated the production of a comprehensive set of canonical cosmids representing the entire genome.

II. SUMMARY OF THE INVENTION

In order to avoid the numerous technical constraints encountered in the state of the art, as decribed hereabove, when using genomic mycobacterial DNA libraries constructed in cosmid clones, the inventors have attempted to realize genomic mycobacterial DNA libraries in an alternative type of vectors, namely Bacterial Artificial Chromosome (BAC) vectors.

The success of this approach depended on whether the resulting BAC clones could maintain large mycobacterial DNA inserts. There are various reports describing the successful construction of a BAC library for eucaryotic organisms (Cai et al., 1995; Kim et al., 1996; Misumi et al., 1997; Woo et al., 1994; Zimmer et al., 1997) where inserts up to 725 kb (Zimmer et al., 1997) were cloned and stably maintained in the E. coli host strain.

Here, it is shown that, surprisingly, the BAC system can also be used for mycobacterial DNA, as 70% of the clones contained inserts in the size of 25 to 104 kb.

This is the first time that bacterial, and specifically mycobacterial, DNA is cloned in such BAC vectors.

In an attempt to obtain complete coverage of the genome with a minimal overlapping set of clones, a Bacterial Artificial Chromosome (BAC) library of M. tuberculosis was constructed, using the vector pBeloBAC11 (Kim et al., 1996) which combines a simple phenotypic screen for recombinant clones with the stable propagation of large inserts (Shizuya et al., 1992). The BAC cloning system is based on the E. coli F-factor, whose replication is strictly controlled and thus ensures stable maintenance of large constructs (Willets et al., 1987). BACs have been widely used for cloning of DNA from various eucaryotic species (Cai et al., 1995; Kim et al., 1996; Misumi et al., 1997; Woo et al., 1994; Zimmer et al., 1997). In contrast, to our knowledge this report describes the first attempt to use the BAC system for cloning bacterial DNA.

A central advantage of the BAC cloning system over cosmid vectors used in prior art is that the F-plasmid is present in only one or a maximum of two copies per cell, reducing the potential for recombination between DNA fragments and, more importantly, avoiding the lethal overexpression of cloned bacterial genes. However, the presence of the BAC as just a single copy means that plasmid DNA has to be extracted from a large volume of culture to obtain sufficient DNA for sequencing and it is described here in the examples a simplified protocol to achieve this.

Further, the stability and fidelity of maintenance of the clones in the BAC library represent ideal characteristics for the identification of genomic differences possibly responsible for phenotypic variations in different mycobacterial species.

As it will be shown herein, BACs can be allied with conventional hybridization techniques for refined analyses of genomes and transcriptional activity from different mycobacterial species.

Having established a reliable procedure to screen for genomic polymorphisms, it is now possible to conduct these comparisons on a more systematic basis than in prior art using representative BACs throughout the chromosome and genomic DNA from a variety of mycobacterial species.

As another approach to display genomic polymorphisms, the inventors have also started to use selected H37Rv BACs for “molecular combing” experiments in combination with fluorescent in situ hybridization (Bensimon et al., 1994; Michalet et al., 1997). With such techniques the one skilled in the art is enabled to explore the genome of mycobacteria in general and of M. tuberclosis in particular for further polymorphic regions.

The availability of BAC-based genomic mycobacterial DNA libraries constructed by the inventors have allowed them to design methods and means both useful to identify genomic regions of interest of pathogenic mycobacteria, such as Mycobacterium tuberculosis, that have no counterpart in the corresponding non-pathogenic strains, such as Mycobacterium bovis BCG, and useful to detect the presence of polynucleotides belonging to a specific mycobacterium strain in a biological sample.

By a biological sample according to the present invention, it is notably intended a biological fluid, such as plasma, blood, urine or saliva, or a tissue, such as a biopsy.

Thus, a first object of the invention consists of a method for isolating a polynucleotide of interest that is present in the genome of a mycobacterium strain and/or is expressed by said mycobacterium strain and that is absent or altered in the genome of a different mycobacterium strain and/or is not expressed in said different mycobacterium strain, said method comprising the use of at least one clone belonging to a genomic DNA library of a given mycobaterium strain, said DNA library being cloned in a bacterial artificial chromosome (BAC).

The invention is also directed to a polynucleotide of interest that has been isolated according to the above method and in partoular a polynucleotide containing one or several Open Reading Frames (ORFs), for example ORFs encoding either a polypeptide involved in the pathogenicity of a mycobacterium strain or ORFs encoding Polymorphic Glycine Rich Sequences (PGRS).

Such polynucleotides of interest may serve as probes or primers in order to detect the presence of a specific myobacterium strain in a biological sample or to detect the expression of specific genes in a particular mycobacterial strain of interest.

The BAC-based genomic mycobacterial DNA libraries generated by the present inventors are also part of the invention, as well as each of the recombinant BAC clones and the DNA insert contained in each of said recombinant BAC clones.

The invention also pertains to methods and kits for detecting a specific mycobacterium in a biological sample using either at least one recombinant BAC clone or at least one polynucleotide according to the invention, as well as to methods and kits to detect the expression of one or several specific genes of a given mycobacterial strain present in a biological sample.

III. BRIEF DESCRIPTION OF THE FIGURES

In order to better understand the present invention, reference will be made to the appended figures which depicted specific embodiments to which the present invention is in no case limited in scope with.

FIGS. 1A and 1B: PCR-screening for unique BAC clones with specific primers for 2 selected genomic regions of the H37Rv chromosome, using 21 pools representating 2016 BACs (Panel A) and sets of 20 subpools from selected positive pools (Panel B).

FIG. 2: Pulsed-field gel electrophoresis gel of DraI-cleaved BAC clones used for estimating the insert sizes of BACs.

FIGS. 3A-3D: Minimal overlapping BAC map of M. tuberclosis H37Rv superimposed on the integrated physical and genetic map established by Philipp et al. (18). Y- and I-numbers show pYUB328 (2) and pYUB412 (16) cosmids which were shotgun sequenced during the H37Rv genome sequencing project. Y-cosmids marked with * were shown in the integrated physical and genetic map (18). Rv numbers show the position of representative BAC clones relative to sequenced Y- and I-clones. Squared Rv numbers show BACs which were shotgun sequenced at the Sanger Centre.

FIGS. 4A and 4B: Ethidium bromide stained gel (Panel A) and corresponding Southern blot (PanelB) of EcoRI and PvuII digested Rv58 DNA hybridized with ³²P labeled genomic DNA preparations from M. tuberclosis H37Rv, M. bovis ATCC 19210 and M. bovis BCG Pasteur.

FIG. 5: Organisation of the ORFs in the 12.7 kb genomic region present in M. tuberculosis H37Rv but not present in M. bovis ATCC 19210 and M. bovis BCG Pasteur. Arrows show the direction of transcription of the putative genes. Positions of EcoRI and PvuII restriction sites are shown. Vertical dashes represent stop codons. The 11 ORFs correspond to the ORFs MTCY277.28 to MTCY277.38/accession number Z79701-EMBL Nucleotide Sequence Data Library. The junction sequences flanking the polymorphic region are shown.

FIG. 6: Variation in the C-terminal part of a PE-PGRS open reading frame in M. tuberculosis strain H37Rv relative to M. bovis BCG strain Pasteur.

The numbers on the right side of the Figure denote the position of the end nucleotides, taking as the reference the M. tuberclosis genome.

FIG. 7: Polynucleotide sequence next to the HindIII cloning site in the BAC vector pBeloBAC11 (Kim et al., 1996) used to clone the inserts of the BAC-based myobacterial genomic DNA library according to the invention.

NotI: location of the NotI restriction sites.

Primer T7-BAC1: nucleotide region recognized by the T7-BAC1 primer shown in Table 1.

T7 promoter: location of the T7 promoter region on the pBeloBac11 vector.

Primer T7-Belo2: nucleotide region recognized by the T7-Belo2 pimer shown in Table 1.

Hind III: the HindIII cloning site used to clone the genomic inserts in the pBeloBAC11 vector.

SP6-Mid primer: nucleotide region recognized by the SP6 Mid primer shown in Table 1.

SP6-BAC1 primer: nucleotide region recognized by the SP6 BAC1 primer shown in Table 1.

SP6 promoter: location of the SP6 promoter region on the pBeloBac11 vector.

IV. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

As already mentioned hereinbefore, the present invention is directed to a method for isolating a polynucleotide of interest that is present in the genome of a mycobacterium strain and/or is expressed by said mycobacterium strain and that is absent or altered in the genome of a different mycobacterium strain and/or is not expressed in said different mycobacterium strain, said method comprising the use of at least one clone belonging to a genomic DNA library of a given mycobaterium strain, said DNA library being cloned in a bacterial artificial chromosome (BAC).

For this purpose, the inventors have constructed several BAC-based mycobacterial genomic DNA libraries that may be used in order to perform the above described method.

Because it is the first time that mycobacterial genomic DNA has been successfully cloned in BAC type vectors, and because these DNA libraries are then novel and nonobvious, an object of the present invention consists in a myobacterial genomic DNA library cloned in such a BAC type vector.

As an illustrative example, a BAC-based DNA library of Mycobacterium tuberculosis has been realized. Forty-seven cosmids chosen from the integrated map of the 4.4 Mb circular chromosome (Philipp et al., 1996a) were shotgun-sequenced during the initial phase of the H37Rv genome sequence project. The sequences of these clones were used as landmarks in the construction of a minimally overlapping BAC map. Comparison of the sequence data from the termini of 420 BAC clones allowed us to establish a minimal overlapping BAC map and to fill in the existing gaps between the sequence of cosmids. As well as using the BAC library for genomic mapping and sequencing, we also tested the system in comparative genomic experiments in order to uncover differences between two closely related mycobacterial species. As shown in a previous study (Philipp et al., 1996b), M. tuberclosis, M. bovis and M. bovis BCG, specifically BCG Pasteur strain, exhibit a high level of global genomic conservation, but certain polymorphic regions were also detected. Therefore, it was of great interest to find a reliable, easy and rapid way to exactly localize polymorphic regions in mycobacterial genomes using selected BAC clones. This approach was validated by determining the exact size and location of the polymorphisms in the genomic region of Dral fragment Z4 (Philipp et al., 1996b), taking advantage of the availability of an appropriate BAC clone covering the polymorphic region and the H37Rv genome sequence data. This region is located approximately 1.7 Mb from the origin of replication.

The Bacterial Artificial Chromosome (BAC) cloning system is capable of stably propagating large, complex DNA inserts in Escherichia coli. As part of the Mycobacterium tuberculosis H37Rv genome sequencing project, a BAC library was constructed in the pBeloBAC11 vector and used for genome mapping, confirmation of sequence assembly, and sequencing. The library contains about 5000 BAC clones, with inserts ranging in size from 25 to 104 kb, representing theoretically a 70 fold coverage of the M. tuberclosis genome (4.4 Mb). A total of 840 sequences from the T7 and SP6 termini of 420 BACs were determined and compared to those of a partial genomic database. These sequences showed excellent correlation between the estimated sizes and positions of the BAC clones and the sizes and positions of previously sequenced cosmids and the resulting contigs. Many BAC clones represent linking clones between sequenced cosmids, allowing full coverage of the H37Rv chromosome, and they are now being shotgun-sequenced in the framework of the H37Rv sequencing project. Also, no chimeric, deleted or rearranged BAC clones were detected, which was of major importance for the correct mapping and assembly of the H37Rv sequence. The minimal overlapping set contains 68 unique BAC clones and spans the whole H37Rv chromosome with the exception of a single gap of ˜150 kb. As a post-genomic application, the canonical BAC set was used in a comparative study to reveal chromosomal polymorphisms between M. tuberclosis, M. bovis and M. bovis BCG Pasteur, and a novel 12.7 kb segment present in M. tuberclosis but absent from M. bovis and M. bovis BCG was characterized. This region contains a set of genes whose products show low similarity to proteins involved in polysaccharide biosynthesis. The H37Rv BAC library therefore provides the one skilled in the art with a powerfill tool both for the generation and confirmation of sequence data as well as for comparative genomics and a plurality of post-genomic applications.

The above described BAC-based Mycobacterium tuberculosis genomic DNA library is part of the present invention and has been deposited in the Collection Nationale de Cultures de Microorganismes (CNCM) on Nov. 19, 1997 under the accession number I-1945.

Another BAC-based DNA library has been constructed with the genomic DNA of Mycobacterium bovis BCG, Pasteur strain, and said DNA library has been deposited in the Collection Nationale de Cultures de Microorganismes (CNCM) on Jun. 30, 1998 under the accession number I-2049.

Thus, as a specific embodiment of the above described method for isolating a polynucleotide of interest said method makes use of at least one BAC-based DNA library that has beeen constructed from the genomic DNA of Mycobacterium tuberculosis, more specifically of the H37Rv strain and particularly of the DNA library deposited in the accession number I-1945.

In another specific embodiment of the above described method for isolating a polynucleotide of interest said method makes use of at least one BAC-based DNA library has beeen constructed from the genomic DNA of Mycobacterium bovis BCG, more specifically of the Pasteur strain and particularly of the DNA library deposited in the accession number I-2049.

In more details, the method according to the invention for isolating a polynucleotide of interest may comprise the following steps:

a) Isolating at least one polynucleotide contained in a clone of a BAC-based DNA library of mycobacterial origin;

b) Isolating:

at least one genomic or cDNA polynucleotide from a mycobacterium, said mycobacterium belonging to a strain different from the strain used to construct the BAC-based DNA library of step a); or alternatively

at least one polynucleotide contained in a clone of a BAC-based DNA library prepared from the genome of a mycobacterium that is different from the mycobacterium used to construct the BAC-based DNA library of step a);

c) Hybridizing the at least one polynucleotide of step a) to the at least one polynucleotide of step b);

d) Selecting the at least one polynucleotide of step a) that has not formed a hybrid complex with the at least one polynucleotide of step b);

e) Characterizing the selected polynucleotide.

Following the above procedure, the at least one polynucleotide of step a) may be prepared as follows:

1) Digesting at least one recombinant BAC clone by an appropriate resctriction endonuclease in order to isolate the polynucleotide insert of interest from the vector genetic material;

2) Optionally amplifying the resulting polynucleotide insert;

3) Optionally digesting the polynucleotide insert of step 1) or step 2) with at least one restriction endonuclease.

The above method of the invention allows the one skilled in the art to perform comparative genomics between different strains or species of mycobacteria cells, for example between pathogenic strains or species and their non pathogenic strains or species counterparts, as it is the illustrative case for the genomic comparison between Mycobacterium tuberculosis and Mycobacterium bovis BCG that is described herein in the examples.

Restriction digests of a given clone of a BAC library according to the invention may be blotted to membranes, and then probed with radiolabeled DNA form another strain or another species of mycobacteria, allowing the one skilled in the art to identify, characterize and isolate a polynucleotide of interest that may be involved in important metabolical and/or physiological pathways of the mycobacterium under testing, such as a polynucleotide functionally involved in the pathogenicity of said given mycobacteria for its host organism.

More specifically, the inventors have shown in Example 6 that when restriction digests of a given clone of the BAC library identified by the CNCM accession number I-1945 are blotted to membranes and then probed with radiolabeled total genomic DNA from, for example, Mycobacterium bovis BCG Pasteur, it is observed that restriction fragments that fail to hybridize with the M. bovis BCG Pasteur DNA are absent from its genome, hence identifying polymorphic regions between M. bovis BCG Pasteur and M. tuberclosis H37Rv.

Thus, a further object of the present invention consists in a polynucleotide of interest that has been isolated according to the method described herein before.

In Example 6, a polynucleotide of approximately 12.7 kilobases has been isolated that is present in the genome of M. tuberclosis but is absent of the genome of M. bovis BCG. This polynucleotide of interest contains 11 ORFs that may be involved in polysaccharide biosynthesis. In particular, two of said ORFs are of particular interest, namely ORF6 (MTCY277.33; Rv1511) that encodes a protein that shares significant homology with bacterial GDP-D-mannose dehydratases, whereas the protein encoded by ORF7 (MTCY277.34; Rv1512) shares significant homology with a nucleotide sugar epimnerase. As polysaccharide is a major constituent of the mycobacterial cell wall, these deleted genes may cause the cell wall of M. bovis BCG to differ from that of M. tuberclosis, a fact that may have important consequences for both the immune response to M. bovis BCG and virulence. Detection of such a polysaccharide is of diagnostic interest and possibly useful in the design of tuberculosis vaccines.

Consequently, the polynucleotide of interest obtained following the method according to the invention may contain at least one ORF, said ORF preferably encoding all or part of a polypeptide involved in an important metabolical and/or physiological pathway of the mycobacteria under testing, and more specifically all or part of a polypeptide that is involved in the pathogenicity of the mycobacteria under testing, such as for example Mycobacterium tuberculosis, and more generally mycobacteria belonging to the Mycobacterium tuberculosis complex.

The Mycobacterium tuberculosis complex has its usual meaning, i.e. the complex of mycobacteria causing tuberculosis which are Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium africanum, Mycobacterium microti and the vaccine strain Mycobacterium bovis BCG.

An illustrative polynucleotide of interest according to the present invention comprises all or part of the polynucleotide of approximately 12.7 kilobases that is present in the genome of M. tuberclosis but is absent from the genome of M. bovis BCG disclosed hereinbefore. This polynucleotide is contained in clone Rv58 of the BAC DNA library I-1945.

Generally, the invention also pertains to a purified polynucleotide comprising the DNA insert contained in a recombinant BAC vector belonging to a BAC-based mycobacterial genomic DNA library, such as for example the I-1945 BAC DNA library.

Advantageously, such a polynucleotide has been identified according to the method of the invention.

Such a polynucleotide of interest may be used as a probe or a primer useful for specifically detecting a given mycobacterium of interest, such as Mycobacterium tuberculosis or Mycobacterium bovis BCG.

More specifically, the invention then deals with a purified polynucleotide usefill as probe or a primer comprising all or part of the nucleotide sequence SEQ ID N^(o)1:

ACCTGCGCTT GCAGAGATCA AATAGGGCGC ATGGGTCAGC ATAGTACAGG TCGTCGCGCA 60 TCTTTGATGC ATCGGAATAA GATGTCAGGC AATTAAAAGA GAAGCCACGG CGACTCGCGG 120 CATTCAGCAT GTCGAGCGTC GCTTCGATGT GAGCGCACCA TTCCGTGTCC AACGATTTCA 180 GACGAACATT GAATATTCCA CTCGCGACGC TATAGTCCGC CTCCCGATCT ATGCGCGCCG 240 CGCAGATGAA GTCTGCGTTC GCCCGACCTT CGAAACGTAG TGCGGCCGCG CGCACCATTT 300 CGGGGGAGAC GTCGATGCCG GTGTAATCAG TTTTGAAGCC ACGCGCATCT AGGTAGTCCA 360 GTAGAGCCCC ATAGCCACAG CCTAGATCGT TGATCGAAAA TGGGTCCGCC GCATTGACAA 420 TGCGCACCAG CTGGTCAAAG CGCAACGCCT GCCCGGCTTC GCCGTTCCAA TCGACGCCGC 480 GCGGGTGCCG TGTGCTTCGA GTTTCGATGC GTAGTAACGG GCCACGTCAG CGAGCATGGT 540 CGTTGCGTCT TCCGCCATGA AGCTGCCTCA CGATTTGTGT GTGTGGGCGT CGGTGCGTGG 600 GTCCGAGACT ATACCTTCAA CAGTTGCATG CCGAGGCTGC GGCGGGCAAT GACCCAAAAA 660 CCCGCCGGCA CGGTTCGCCG AGCAAGGAAG CGTGGAGACG ATAGATAATT TCACTGGCGA 720 CAGTACCTCA AATAGTCCGG AGCCTCGGCT CCGACGTTAA AGAGCAGATC CAGAATCGAC 760 ACGGCGGGCT CGAACCCTCC CCACAATTGC TTATAATCGC GGTAGCCGTC ATAATCGAAC 840 CAAGTTACCC GGATGCTAAG TTCGTCGAAC ACGCGCTCAT CGACATACGA ACGGGCTGAG 900 GGGCCAGAGA CATATTCGGT CGCTGCGGCC TGTTGGCAGA GGTTGGCCAG TCTCTCGGTC 960 TTGCCGTCGG CTAATTCGTA GTCCCACGAA TTTGCCAGTC GCGTGCTGAT ACCGAGATAA 1020 CTGCAAATCG CATTCAATAG ACGCCTGTTG AGTAAGGAAA GATTCGTGTG CTGTTCTTCG 1080 AGGTAAATCG GCGCGAGCCA GTCAGCGATC TCCGCAAAAT GAGCGGCCGC GCTGTAGTTG 1140 AATTCTAGTG CCCGCCAGTG CGCTTTCGCC CAATCGGTGC CGTCGATCAG CGTCTCACGT 1200 ATCTTTTGAT GGAAACGTCC CTTCACCTGG ACGGGAACAG TTATCCACTG TAACCCCTGG 1260 CTCGTTTTGA TCCGATTTCT GTTTCGCCAA TCACGCTTGG TATATTGCAT GTCATCATAG 1320 ATGATGAATT CATCGACGAA TGCAATCAGG TCAAAATATC CTCGCCAAGG TATGTAATTT 1380 GATTGAACAA TCGCGACTTT CTTCAACGCG GTGTCTCCAA TTTAGAATAA CAAATACGTC 1440 GCGCCCGCGA CAGCTCCGCT GGAGCGAGTT CAAGCGATTC TGCGACATAT TCAATATGGT 1500 GCTCGGGAAG GCCAGGATGG GCCGCGACCC GGGGCGTCCG GTGCGCGATG AACGTCGCAT 1560 CGTCTCCTGT GAGATAATTG CATCCGATCA TATAGGGCTG GCTGCGGCTA GGTTGCTGGC 1620 AAAAAGATAT CGCGGCCGAT CCGTTTCTGG TTTTGTCTTG ATGATCAAAT CCGCTTCCGT 16B0 TCACGAGATC GATTCCTGGT CTTCCCCCAG CGTCGCGATG TCGATAGGTG TCGCGCTTTG 1740 TTCGTACCCG CACTACGCGG CGGCGAGAAC CTCGCCACCG AATCGGGATT GGGGGGAGGA 1800 TACCACTCGG TCGAGGCCCG TCACCGGCCT TCTAGCGGGT TGACCATCAG TGTTTGCAGG 1860 GCCCTATCCC GGTATGGCGC ACCACGGGAT CGGCAGCGTT CCGGTTGCTG GCGTGGTACC 1920 TCGTTGTGGC GCCGTGGTCC ATGTCGATTG AGTGCGTGGA TCAGTGTAAA CCGTTGCGCG 1980 CCATGTTCTG TAGGCACTGG TTCGGGTTGT GGTTAGGCTG CACGGTTGGC AGGTTACCAA 2040 CCACTGAGCC CCTGGGCGGA TGTGAGCTCG GACTCCGCCT ATGGGGTGTA ATTTTGGCAG 2100 ATTGGGCCGG GTCCCCGTGG TGAGGACTCC TCAACCGGAT TGGGTAAGCA TGAGGTGGTG 2160 CTGGCAGCGG TGTCCTGGTC GCTCTCCCGA GTAGGCCCGT TGTGACTGTC ATGTGGGCGA 2220 GCGGGTTTGC GCGCGTAGGA GACGATGATT ACTACGCACG TGACCAACCA CAAGAACGGT 2280 GCCCATGTCA CCGTGGTGAA AACGAGTGGC GTGGTACCGA CTACCCCTTT GGCTCCCAGC 2340 TGTCCATAGA GCGGCACGTA GAACGGCTGG CCCGGGACCG CGACGTTGAC GATGCTCAGC 2400 GCCACGGCCA AACTCACGCA GACGCCGACC GCGCGGCGGC GGTCTCCATG GGCTGCGAGT 2460 TGGTCGAATA TCCCAGCACC AGGAGGCCCG TTGGGGTCTC GGGCTACCAG TGCAGCGATT 2520 GGCAAGACGA AAACGAGATA GTAGAAGGCG ACGTCCGCGG GGGAGAAGGT GGCGGTGGCG 2580 AGCAACACAA TCCCCACCAT GACAGGCGGG ATACGGCGTC CGAGCGCCAG CACGGCGACC 2640 ACGACTATGA CTAGGACAGC AAACCCGATC TGCGTTCGCG GACCAGTGAG GAAACCCTCT 2700 GGGATCTTGC CCGATTGATA GTTCTTGATG CTATCGGGGA TCAGCAGGAG TGCCTTGCCA 2760 AAGGACACGT TCCGCGGGTC TCGAAGCCCT CCGAACGAAC TATTGAACTT GATGATGCCG 2820 TGGATCGACT GTGCGATCGT CCCCGGGAAG CCTCGTGGCC ACAACAGAAA GGCTGCGATA 2880 TTGGACACCA CCACGCCGGT GATCCCGATA CCAGCCCACC GCCATTGTCG AGCCGCCAAC 2940 AACACCACGC CGAGAACGAC GAACTGCGGC TTTACCAGGA CGGCCAAGAT CACCGTGATG 3000 GTGGCGAGGC CCCACCGCTG TCGGGACAAC GCCACGAAGT AAGCCAGCGC GATCGGTACC 3060 ACGAACCCTG TCGAGTTGCC TCGATCGATG ACCCCCCACG CCGGGATGGC CGCGGCGCCC 3120 AGTGTCACGA AGATGACCAC TCGCTCCAGA CCACGTGCCC CCCGGGCCGC CCAGATGGCG 3180 GGAGATATGA CCGCCATCGT TAGGGCGACC AGGTAACAGA TCAGCCCCAA GCGCGGCGCA 3240 CCCAGCCAAT GGCTGGGTAG TCCGAAAATC GCATACGGTA TGCGGGCGGG GGCCCATGCA 3300 GCAACCGCGG TCGGCTGGTA ATCGGCGGGT AGCGAGATCA GGTAGTCCGC GGGATTGGGT 3360 TGAATCCCGG CGGCGGCGAC CATGGCGTAG TCGCTGAAGC AGTGCCGACC GATATTCATG 3420 CCCCAATCAA GCCAACAGTC CCCAGGGACT ACCAAAAGAG TGGAAAAGAC GTCGACCGCG 3480 TACCACTGAC TGAGGGCGTA CGCCGTCGCC GCCGAAATCA CCGACGCCAG CAGGATGGTG 3540 CCGAGCATGA GGGTGCGCTC GGATTGGGAG CCGATCGCCC AGAGCCGCTC CCGGCTCGCG 3600 GTCACGGCAC CGCGCAACAC CTCCGGGGGT CGCTTCATCT GGATTCTCCT CGGTTCTGCG 3660 CGAAACGGTA GCAGAGCGCC ATGGTTGCCA ACGCGGTCGC CGGGCAGTCT AGACCGGATC 3720 TTCCTCGTGG CAACCGACAA CAGGACGTCG TTGCCGAAAG GGCGCTGGGC ACCGACATCT 3780 AGGATGAACC CACAGCCACG CCCCGACGTT ATGCCATGGC GAAGAGCGAC CGGCAGGAGC 3840 GGGAACCCAG TGAAGCGAGC GCTCATCACC GGAATCACAG GACCGGACGG CTCGTATCTC 3900 GCTAAGCTCC CGCTGAAGGG ATATGTGGCC GCTGGTAGCC CGGCCGAGGT CTATTTCTGC 3960 TGGGCGACAC GGAATTATCG CGAATTGTAT GGGTTGCTCG CGGTCAACAG CATCTGGTTC 4020 AATCACGAAT CACCGCGTCA CGGCGAGACA TTCATGACTC GTAATCCTGC ACCATATCGC 4080 GGTCGGCAAC GAGGCGCTGA TCGATGCGCA GACGCTGATG CGCCGGCCCA CCCGGATAGG 4140 TATCAGTATT GGGGCGTTCC GGCCAGCGTA CGAGGCGTGA TCGACCGCGC AATGGGTGTT 4200 TGCGTTGAGT AATAATCTGA ACCGTGTGAA CGCATGCATG GATGGATTCC TTGCCCGTAT 4260 CCGCTCACAT GTTGATGCGC ACGCGCCAGA ATTGCGTTCA CTGTTCGATA CGATGGCGGC 4320 CGAGGCCCGA TTTGCACGCG ACTGGCTGTC CGAGGACCTC GCGCGGTTGC CTGTCGGTGC 4380 AGCATTGCTG GAAGTGGGCG GGGGGGTACT TCTGCTCAGC TGTCAACTGG CGGCGGAGGG 4440 ATTTGACATC ACCGCCATCG AGCCGACGGG TGAAGGTTTT GGCAAGTTCA GACAGCTTGG 4500 CGACATCGTG CTGGAATTGG CTGCAGCACG ACCCACCATC GCGCCATGCA AGGCGGAAGA 4560 CTTTATTTCC GAGAAGCGGT TCGACTTCGC CTTCTCGCTG AATGTGATGG AGCACATCGA 4620 CCTTCCGGAT GAGGCAGTCA GGCGGGTATC GGAAGTGCTG AAACCGGGGG CCAGTTACCA 4680 CTTCCTGTGC CCGAATTACG TATTCCCGTA CGAACCGCAT TTCAATATCC CAACATTCTT 4740 CACCAAAGAG CTGACATGCC GGGTGATGCG ACATCGCATC GAGGGCAATA CGGGCATGGA 4800 TGACCCGAAG GGAGTCTGGC GTTCGCTCAA CTGGATTACG GTTCCCAAGG TGAAACGCTT 4860 TGCGGCGAAG GATGCGACGC TGACCTTGCG CTTCCACCGT GCAATGTTGG TATGGATGCT 4920 GGAACGCGCG CWGACGGATA AGGAATTCGC TGGTCGCCGG GCACAATGGA TGGTCGCTGC 4980 TATTCGCTCG GCGGTGAAAT TGCGTGTGCA TCATCTGGCA GGCTATGTTC CCGCTACGCT 5040 GCAGCCCATC ATGGATGTGC GGCTAACGAA GAGGTAATGA CATGGCGCAA GCGACATCGG 5100 GCATTCGCGC GGCACTTTCG CAACCTGCTG TGTATGAGGC GTATCAGCGG ATTGCGGGCG 5160 CTAAAAGCGG GCTTGCGTGG ATCACAACCG ACCCCATCCA GTCGTTGCCA GGCATGCGTA 5220 CTCTCGACCT CGGTTGCTGG CCAGCGGTGA TACACAGCTC CCCGCCAGTG GACGTGACAT 5280 GTACGAGAGA CGGCATGAGC GCGGAATGTG CGACCGTGCC GTCGAGATGA CCGACGTCGG 5340 CGCTACGGCA GCCCCCACCG GACCTATCGC GCGGGGCAGC GTCGCTCGGG TCGGCGCGGC 5400 GACCGCGTTG GCCGTTGCCT GCGTCTACAC GGTCATCTAT CTGGCGGCCC GCGACCTACC 5460 CCCGGCTTGT TTTTCGATAT TCGCGGTGTT TTGGGGGGCG CTCGGCATTG CCACCGGCGC 5520 CACCCACGGC CTCCTGCAAG AAACGACCCG CGAGGTCCGC TGGGTGCGCT CCACCCAAAT 5580 AGTTGCGGGC CATCGTACCC ATCCGCTGCG GGTGGCCGGG ATGATTGGCA CCGTCGCGGC 5640 CGTCGTAATT GCGGGTAGCT CACCGCTGTG GAGCCGACAG CTATTCGTCG AGGGGCGCTG 5700 GCTGTCCGTG GGGCTACTCA GCGTTGGGGT GGCCGGGTTC TGCGCGCAGG CGACCCTGCT 5760 GGGCGCGCTG GCCGGCGTCG ACCGGTGGAC ACAGTACGGG TCACTGATGG TGACCGACGC 5820 GGTCATCCGG TTGGCGGTCG CCGCGGCAGC GGTTGTGATC GGATGGGGTC TGGCCGGGTA 5880 CTTGTGGGCC GCCACCGCGG GAGCGGTGGC GTGGCTGCTC ATGCTGATGG CCTCGCCCAC 5940 CGCGCGCAGC GCGGCCAGCC TGCTGACGCC CGGGGGAATC GCCACGTTCG TGCGCGGTGC 6000 CGCTCATTCG ATAACCGCCG CGGGTGCCAG CGCGATTCTG GTAATGGGTT TCCCAGTGTT 6060 GCTCAAAGTG ACCTCCGACC AGTTAGGGGC AAAGGGCGGA GCGGTCATCC TGGCTGTGAC 6120 CTTGACGCGT GCGCCGCTTC TGGTCCCACT GAGCGCGATG CAAGGCAACC TGATCGCGCA 6180 TTTCGTCGAC CGGCGCACCC AACGGCTTCG GGCGCTGATC GCACCGGCGC TGGTCGTCGG 6240 CGGCATCGGT GCGGTCGGGA TGTTGGCCGC AGGGCTTACC GGTCCCTGGT TGCTGCGTGT 6300 TGGATTCGGC CCCGACTACC AAACTGGCGG GGCGTTGCTG GCCTGGTTGA CGGCAGCGGC 6360 GGTAGCTATC GCCATGCTGA CGCTGACCGG CGCCGCCGCG GTCGCGGCCG CACTGCACCG 6420 GGCGTATTTG CTGGGCTGGG TCAGCGCGAC GGTGGCGTCG ACGCTGTTGC TGCTGCTGCC 6480 GATGCCGCTG GAGACGCGCA CCGTGATCGC GCTGTTGTTC GGTCCAACGG TGGGAATCGC 6540 CATCCATGTG GCCGCGTTGG CGCGGCGACC CGACTGATTT GTGCCCCAGG TCGACAAATC 6600 ACGCCGTCTC GTCAGTGAGC ACTCCGTCCT CGGGTCCGAT CCTTCCAGGA GACGTTGCAA 6660 CCTGATTTGG CTCAAATTGG TGCGCACCGA GGGTCGGGCA CATCGTAGGG TCGCAACAGT 6720 CACATGTGTC ACTGCACCGG GCGACACCCG ATGTCCCGGC TCTCAGCGAC AGCTGTCTGA 6780 CCTGTGGTTT TGTTCCCAAG TTGGTCGTGG CTGTGCGGGA TTGGAGGTGG CGTGGGGGTC 6840 GCGTCGTATG GATTCTCCTC CTCGGTTCCG CGCGAAACGG CCGCAGGCGC AATGGTCACC 6900 AACTTGGCCG CGGTGGAGTC TAGCCTCACA TTTTCCTGGT CGCCCCCGAC AACCAGGAGG 6960 TCGCTGCAGA ACGGGCGTTC CCTACCCACA TCTACTATGA AGCGACAGCG GCGCCCCGCT 7020 GTGATGGCTG AGCATGACCG ACAGAGGCGG GAAGACAGTG AAGCGAGCGC TCATCACCGG 7080 AATCACCGGC CAGGACGGCT CGTATCTCGC CGAACTGCTG CTGGCCAAGG GGTATGAGGT 7140 TCACGGGCTC ATCCGGCGCG CTTCGACGTT CAACACCTCG CGGATCGATC ACCTCTACGT 7200 CGACCCGCAC CAACCGGGCG CGCGGCTGTT TCTGCACTAT GGTGACCTGA TCGACGGAAC 7260 CCGGTTGGTG ACCCTGCTGA GCACCATCGA ACCCGACGAG GTGTACAACC TGGCGGCGCA 7320 GTCACACGTG CGGGTGAGCT TCGACGAACC CGTGCACACC GGTGACACCA CCGGCATGGG 7380 ATCCATGCGA CTGCTGGAAG CCGTTCGGCT CTCTCGGGTG CACTGCCGCT TCTATCAGGC 7440 GTCCTCGTCG GAGATGTTCG GCGCCTCGCC GCCACCGCAG AACGAGCTGA CGCCGTTCTA 7500 CCCGCGGTCA CCGTATGGCG CCGCCAAGGT CTATTCGTAC TGGGCGACCC GCAATTATCG 7560 CGAAGCGTAC GGATTGTTCG CCGTTAACGG CATCTTGTTC AATCACGAAT CACCGCGGCG 7620 CGGTGAGACG TTCGTGACCC GAAAGATCAC CAGGGCCGTG GCACGCATCA AGGCCGGTAT 7680 CCAGTCCGAG GTCTATATGG GCAATCTGGA TGCGGTCCGC GACTGGGGGT ACGCGCCCGA 7740 ATACGTCGAA GGCATGTGGC GGATGCTGCA GACCGACGAG CCCGACGACT TCGTTTTGGC 7800 GACCGGGCGC GGTTTCACCG TGCGTGAGTT CGCGCGGGCC GCGTTCGAGC ATGCCGGTTT 7860 GGACTGGCAG CAGTACGTGA AATTCGACCA ACGCTATCTG CGGCCCACCG AGGTGGATTC 7920 GCTGATCGGC GACGCGACCA AGGCTGCCGA ATTGCTGGGC TGGAGGGCTT CGGTGCACAC 7980 TGACGAGTTG GCTCGGATCA TGGTCGACGC GGACATGGCG GCGCTGGAGT GCGAAGGCAA 8040 GCCGTGGATC GACAAGCCGA TGATCGCCGG CCGGACATGA ACGCGCACAC CTCGGTCGGC 8100 CCGCTTGACC GCGCGGCCCG GGTCTACATC GCCGGGCATC GCGGCCTGGT CGGGTCCGCG 8160 CTGCTACGCA CGTTTGCGGG CGCGGGGTTC ACCAACCTGC TGGTGCGGTC ACGCGCCGAG 8220 CTTGATCTGA CGGATCGGGC CGCGACGTTC GACTTCGTTC TCGAGTCGAG GCCGCAGGTC 8280 GTCATCGACG CGGCGGCCCG GGTCGGCGGC ATCCTGGCCA ACGACACCTA CCCGGCCGAT 8340 TTCCTGTCGG AAAACCTCCA GATCCAGGTC AACCTGCTGG ATGCCGCCGT GGCGGCGCGG 8400 GTGCCGCGGC TGCTGTTCCT GGGCTCGTCG TGCATCTACC CGAAACTCGC CCCGCAGCCG 8460 ATCCCGGAGA GCGCGCTGCT CACCGGTCCG TTGGAGCCGA CCAACGACGC GTACGCGATC 8520 GCCAAAATCG CCGGCATCCT TGCGGTCCAG GCGGTGCGCC GCCAACATGG CCTGCCGTGG 8S80 ATCTCGGCGA TGCCCACCAA CCTGTACGGG CCAGGCGACA ACTTTTCGCC GTCCGGCTCG 8640 CATCTGCTGC CGGCACTCAT CCGCCGCTAT GACGAGGCCA AAGCCAGTGG CGCGCCCAAC 8700 GTGACCAACT GGGGCACCGG CACGCCCCGA CGGGAGTTGC TGCACGTCGA CGACCTGGCG 8760 AGCGCATGCC TGTATCTGCT GGAACATTTC GACGGGCCGA CCCATGTCAA CGTGGGAACC 8820 GGCATCGACC ACACCATCGG CGAGATCGCC GAGATGGTCG CCTCGGCGGT AGGCTATAGC 8880 GGCGAAACCC GCTGGGATCC AAGCAAACCG GACGGAACAC CACGCAAACT GCTGGATGTT 8940 TCGGTGCTAC GGGAGGCGGG ATGGCGGCCT TCGATCGCGC TGCGCGACGG CATCGAGGCG 9000 ACGGTGGCGT GGTATCGCGA GCACGCGGGA ACGGTTCGGC AATGAGGCTG GCCCGTCGCG 9060 CTCGGAACAT CTTGCGTCGC AACGGCATCG AGGTGTCGCG CTACTTTGCC GAACTGGACT 9120 GGGAACGCAA TTTCTTGCGC CAACTGCAAT CGCATCGGGT CAGTGCCGTG CTCGATGTCG 9180 GGGCCAATTC GGGGCAGTAC GCCAGGGGTC TGCGCGGCGC GGGCTTCGCG GGCCGCATCG 9240 TCTCGTTCGA GCCGCTGCCC GGGCCCTTTG CCGTCTTGCA GCGCAGCGCC TCCACGGACC 9300 CGTTGTGGGA ATGCCGGCGC TGTGCGCTGG GCGATGTCGA TGGAACCATC TCGATCAACG 9360 TCGCCGGCAA CGAGGGCGCC AGCAGTTCCG TCTTGCCGAT GTTGAAACGA CATCAGGACG 9420 CCTTTCCACC AGCCAACTAC GTGGGCGCCC AACGGGTGCC GATACATCGA CTCGATTCCG 9480 TGGCTGCAGA CGTTCTGCGG CCCAACGATA TTGCGTTCTT GAAGATCGAC GTTCAAGGAT 9S40 TCGAGAAGCA GGTGATCGCG GGTGGCGATT CAACGGTGCA CGACCGATGC GTCGGCATGC 9600 AGCTCGAGCT GTCTTTCCAG CCGTTGTACG AGGGTGGCAT GCTCATCCGC GAGGCGCTCG 9660 ATCTCGTGGA TTCGTTGGGC TTTACGCTCT CGGGATTGCA ACCCGGTTTC ACCGACCCCC 9720 GCAACGGTCG AATGCTGCAG GCCGATGGCA TCTTCTTCCG GGGCAGCGAT TGACGCGCCG 9780 GCGCGTCAAT CTATTTCGAC ATTCGCGTGA AGACGTTTTC CCAGAATCGA CTGTTGTAGG 9840 CGTAGAACTC CCGGCCGCGT AGGTAGGCAT GTGATATTCG CCTTCCCCCG AACGGGTAGC 9900 GGCGATGAAG GTCGCCCATG CGGCGCAGAT CACCGAAGAC CGCGCTTGGT TCCCGGTGCG 9960 AGCCGACGCC CGTGGTGTCG AACTCGCACA GCACACACCG AATCGTGACC GGCTCGCATA 10020 CCAGCGCGGC CCGCAATATG AATTCCTGGT CGGCGGCGAT CCCGAAATCA AGGTCGTAGC 10080 CACCGATCTT GGCCACCAGC GATGATCCGA AGAACGATGC TTGATGCGGA ACAACCTGCT 10140 TGCCGGCCAG GAATTTGCGC AGGCTGAAAG GTATCGGGCC GCGCACCCGA TCGAGCCCGA 10200 CGAGACGATC CATCCCGAAG CCCCACAATT CGGACACCGG TCCCTTGCCG GATAGCGCCT 10260 CCACGGCCTG GGCTACCACG TCGGGCCCGG AAAAACGATC GGCGGAGTGC AAGAACCACA 10320 ACAGATCACC CGATGCGTGC GCGATGCCCT GGTTCATCGC GTCGTACCGC CCGCCGTCGG 10380 GCTCGGACTG CCAATACGCG AAGCCTGGTT CACACCCGGA CAGGTATGCC ACCACGTCGT 10440 CGCCGCTGCC ACCGTCGATT ACGATGTGCT CGATGCGTCC CCGGTAGCGT TGCGCCCGCA 10500 CACTTTTCAC CGTGCGCTGC AACCCGTCGA GGTCGTTGAA CGAGATCGTT ATCACCGAGA 10560 CGGTCGGAGC AGACGTCACC GAGTTCCCCT AGGTTGCTGG CGGCGATTGT GGATCACCGG 10620 GTCTTGATAC CGATGAAGGT GCCTCGAAGA TTCGCCGCAT AGGAACCTCC GAGCAACGAC 106B0 TCGGCGATGC TTGGTTCCAA GTTGTCGTAC TCCTCCATCA CCAGGTCGAC GCCGACGTCT 10740 TTGATGGCCT GAAGTAGGTG CTCGCGTTGA ATCCAGAATG ACCGGCGATT GTCCCAGGAC 10800 GCCCATTTTG CGGTGTCGCG CTGGCCAAAC GAGCGGTCGT CGGAAAACTC GGTAAACCAC 10860 CTACCGGGAA GTCCCTCATG TTCGGTGGGC GCCGAGAGCA TGAACTTCAC CGGCGCCGGC 10920 CGCCGCAGCA ACCGATCGGT CAATTGTCGT GCCGTCGTGG GCAACCGGAG CCATTTATCG 10980 CTCCGGTTGA TGATCGAGAA GTGCGTCTGG AGAATCAGCA GCTTGTTCGT TACCGACGAG 11040 AGGGTTTCCA GGTATTGCTT CGGATTCTCC AGGTGGTAGA AGAGGCCGCA GCAGAAGACG 11100 GTATCGAAGA GCCCGTGGTT GGCGATGTTG AGGGCGTTGT CGTGGACGAA CCGGAGATTC 11160 GGCAGGTTGG TCTTCGATTT GATGTAGTTG CAGGCCGCCA TGTTCAGCTC GCGAACCTCG 11220 ATCCCGAGGA CCTGAAATCC CATGCGCGCG AACCCGACCG CGTACCCGCC TTCCAAGCAG 11280 CCGACATCGG CCAGGCGTAG GTGGCTCTTG TCCCCGGGAA AGACGGTTTC CAGAATCCCG 11340 CGCGCCGAGA TGAACCAGGA CGATTCGTCT AACGTGCGCG AGGACTCCGG TATCGTCAAG 11400 GTTCCGTCGT CGAGGCGAAC GTTGTGGGCG GTGAATTGTA CCGCGCCGGC CGAATGTTCC 11460 TGTGCCATCA CTTGGTTAGC CCCTTCGGCT GGTCCTGGGT TTGTCGACAT GGTCAGGCTC 11520 GACAGCCGCG TCGGAGCCGG GAGGGCCACA CATCCACGAG CCCCCTGCGG CTCGGCGTCG 11580 CGGCGGCGAG CTTGCGCCAC TGGGTCTTGA GCCGCCGCGC GGGTGTCGCC CCGCGGTGCT 11640 GCAGCGCCAG CATGGCGATC CGGGGATGGC GCGCGATGGT TTCCTGCAGC GCGGCGCGCC 11700 CCTCCGGGCC TGGAACGTTG GCGATCTGGC GAAGGATCCA GTCGGCCATG ACGGCGATGA 11760 GCTCCTCGCG CGCGGGGTCT CCCGGGAACA GGTCGAGCAT CGCGTCAAAC GTCGCCGCAT 11820 GCCCCGGACC CTGCGTCAAC CAGAACTTTG GCGGGTCCAC CACCTGGTTG TGCCACATGC 11880 CTTGGGCGTG GCGGCGATAC ACGGCCATGG TGTCGGGCAA CATGGCGATG TCGCCATGCA 11940 CCGCGTGCCG GACGTGCAGA TACCAGTCCA GGGGCATGAC GTCGGCAGGA ATGTCGTCGT 12000 AGCGCTCGAG GCGACGGTAC ACGGCCGAGT TGGTCTGGAT GAAGTTCATC AAGATCAACG 12060 CATCCAGGCT CAAGTTGCCC CGCACCCGAA CCGGGGGGAA CTTCGAGTCC TTGGCATGGC 12120 CGTCCTCCCA TATCACTCGG ACGGGATGGA AGCACACCGT CGTCTTGGGG TGCCGGTCGA 12180 GGAATGCGAC CTGTTTGCTT AGCTTCAGCG GATCGATCCA GTAGTCGTCC GCCTCGCACA 12240 ACGCGACGTA CTCGCCGCGA GCGGCCGACA GGGCGCCGGT CAGGTTCCCA TTGAGGCCGA 12300 GGTTTTCGGT CCTGAAGATC GGCCGGAACA CGTGCGGGTA CCGCTCGGCG TACTCACGGA 12360 TGATCGCCGG GGTGGCATCG GTCGACGCGT CGTCGGCGAC GATGATCTCC ACCGGGAAGT 12420 CGGTTTGCTG GTCGAGAAAG CTGTCGAAGG CCTGACGGGC GTAGCCCGCC TGGTTGTGAG 12480 TGGTCGAGAC GATGCTCACC TTGGGGCAAA GCTGGGGACT CACCGTCGGC CCTTTTCCTG 12540 CGCGGCCGCA AGGGTATTGC GATGGCGAAC GTGAATCGCC TGTGCCCGCC GGCCGTCGGC 12600 CGTCGTGGCC TGGTGGTCGG CGGACGTACG GCACACGCTG GCGAAGTATA GCGAGGGTGC 12660 ACTGACGTTG GGCTCGAACC GCGTGGCGCG CGGTGTGGGC GCACCGTCTC GAGTCGGTGC 12720 TGGTTGGCTC GC 12732

The location, on the Mycobacterium tuberculosis chromosome, of the above polynucleotide of sequence SEQ ID N^(o)1 has now been ascribed to begin, at its 5′ end at nucleotide at position nt 1696015 and to end, at its 3′ end, at nucleotide at position nt 1708746.

For diagnostic purposes, this 12.7 kb deletion should allow a rapid PCR screening of tubercle isolates to identify whether they are bovine or human strains. The primers listed in Table 1 are flanking the deleted region and give a 722 bp amplicon in M. bovis or M. bovis BCG strains, but a fragment of 13,453 bp in M. tuberclosis that is practically impossible to amplify under the same PCR conditions. More importantly, assuming that some of the gene products from this region represent proteins with antigenic properties, it could be possible to develop a test that can reliably distinguish between the immune response induced by vaccination with M. bovis BCG vaccine strains and infection with M. tuberclosis or that the products (e.g. polysaccharides) are specific immunogens.

The invention also provides for a purified polynucleotide usefill as a probe or as a primer, said polynucleotide being chosen in the following group of polynucleotides:

a) a polynucleotide comprising at least 8 consecutive nucleotides of the sequence SEQ ID N⁰1.

b) a polynucleotide whose sequence is fully complementary to the sequence of the polynucleotide defined in a);

c) a polynucleotide that hybridizes under stringent hybridization conditions with the polynucleotide defined in a) or with the polynucleotide defined in b).

For the purpose of defining a polynucleotide or oligonucleotide hybridizing under stringent hybridization conditions, such as above, it is intended a polynucleotide that hybridizes with a reference polynucleotide under the following hybridization conditions:

The hybridization step is realized at 65° C. in the presence of 6×SSC buffer, 5×Denhardt's solution, 0,5% SDS and 100 μg/ml of salmon sperm DNA.

For technical information, 1×SSC corresponds to 0.15 M NaCl and 0.05M sodium citrate; 1×Denhardt's solution corresponds to 0.02% Ficoll, 0.02% polyvinylpyrrolidone and 0.02% bovine serum albumin.

The hybridization step is followed by four washing steps:

two washings during 5 min, preferably at 65° C. in a 2×SSC and 0.1%SDS buffer;

one washing during 30 min, preferably at 65° C. in a 2×SSC and 0.1% SDS buffer,

one washing during 10 min, preferably at 65° C. in a 0.1×SSC and 0.1%SDS buffer

A first illustrative useful polynucleotide that is included in the polynucleotide of sequence SEQ ID N^(o)1 is the following polynucleotide of sequence SEQ ID N^(o)2 that corresponds to the Sp6 endsequence of SEQ ID N^(o)1:

ATACTCAAGC TTGCCGCAAT CGAAACCAAC CTGTTTGTGC CGCAAGAAAT TACGCCGTGG  60 CCCGGCGCCG ATCAAGAAAC GCCCCGGCGC GCGGCGGTGT CGTCGTATGG CATGACGGGC 120 ACCAATGTGC ACGCCATTGT CGAGCAGGCA CCGGTGCCAG CCCCCGAATC CGGTGCACCA 180 GGCGACACCC CGGCCACACC CGGTATCGAC GGCGCGCTGC TGTTCGCGCT GTCGGCCAGC 240 TCGCAGGACG CGCTGCGGCA AACCGCCGCG CGGCTGGCCG ATTGGGTCT 289

A second illustrative useful polynucleotide that is included in the polynucleotide of sequence SEQ ID N^(o)1 is the following polynucleotide of sequence SEQ ID N^(o)3 that corresponds to the T7 endsequence of SEQ ID N^(o)1, located on the opposite strand:

TTGGCGGGTT GGCCACACAC CCGCCGGTGA CGGCGACGAT GCTGGGCTGG TTGCGGCCCT  60 GCGCCACCGC GGCTTGCATG CTGGTTGGCT GTCTTGGGAC GATCCCGAAA TAGTCCACGC 120 GGATCTGGTG ATTTTGCGGG CTACCCGCGA TTACCCCGCG CGGCTCGACG AGTTTTTGGC 180 CTGGACTACC CGCGTGGCCA ATCTGCTGAA CTCGCGGCCG GTGGTGGCCT GGAATGTCCA 240 CGCCGTTCAC CTACGTGACC TTGATGGGAT CCGGGGGT 278

The polynucleotide of sequence SEQ ID N^(o)1 contains 11 ORFs, the respective locations of which, taking into account the orientation of each ORF on the chromosome, on the sequence of the Mycobacterium tunerculosis chromosome, is given hereafter:

The location of ORF1 is comprised between nucleotide at position nt 1695944 and nucleotide at position nt1696441.

The location of ORF2 is comprised between nucleotide at position nt 1696728 and nucleotide at position nt1697420.

The location of ORF3 is comprised between nucleotide at position nt 1698096 and nucleotide at position nt1699892. ORF3 probably encodes a protein having the characteristics of a membrane protein.

The location of ORF4 is comprised between nucleotide at position nt 1700210 and nucleotide at position nt1701088.

The location of ORF5 is comprised between nucleotide at position nt 1701293 and nucleotide at position nt1702588. ORF5 encodes a protein having the characteristics of a membrane protein.

The location of ORF6 is comprised between nucleotide at position nt 1703072 and nucleotide at position nt1704091. ORF6 encodes a protein having the characteristics of a GDP-D-mannose dehydratase.

The location of ORF7 is comprised between nucleotide at position nt 1704091 and nucleotide at position nt1705056. ORF7 encodes a protein having the characteristics of a nucleotide sugar epimerase involved in colanic acid biosynthesis.

The location of ORF8 is comprised between nucleotide at position nt 1705056 and nucleotide at position nt1705784.

The location of ORF9 is comprised between nucleotide at position nt 1705808 and nucleotide at position nt1706593. ORF9 encodes a protein having the characteristics of colanic acid biosynthesis glycosyl transferase.

The location of ORF10 is comprised between nucleotide at position nt 1706631 and nucleotide at position nt1707524.

The location of ORF11 is comprised between nucleotide at position nt 1707530 and nucleotide at position nt1708648. ORF11 encodes a protein similar to a spore coat polysaccharide biosynthesis.

A polynucleotide of interest obtained by the above-disclosed method according to the invention may also contain at least one ORF that encodes all or part of acidic, glycine-rich proteins, belonging to the PE and PPE families, whose genes are often clustered and based on multiple copies of the polymorphic repetitive sequences. The names PE and PPE derive from the fact that the motifs ProGlu (PE, positions 8, 9) and ProProGlu (PPE, positions 7 to 9) are found near the N-terminus in almost all cases. The PE protein family all have a highly conserved N-terminal domain of ˜110 amino acid residues, that is predicted to have a globular structure, followed by a C-terminal segment which varies in size, sequence and repeat copy number. Phylogenetic analysis separated the PE family into several groups, the larger of which is the highly repetitive PGRS class containing 55 members whereas the other groups share very limited sequence similarity in their C-terminal domains. The predicted molecular weights of the PE proteins vary considerably as a few members only contain the ˜110 amino acid N-terminal domain while the majority have C-terminal extensions ranging in size from 100 up to >1400 residues. A striking feature of the PGRS proteins is their exceptional glycine content (up to 50%) due to the presence of multiple tandem repetitions of GlyGlyAla or GlyGlyAsn motifs or variations thereof.

Like the PE family, the PPE protein family also has a conserved N-terminal domain that comprises ˜180 amino acid residues followed by C-terminal segments that vary considerably in sequence and length. These proteins fall into at least three groups, one of which constitutes the MPTR class characterised by the presence of multiple, tandem copies of the motif AsnXGlyXGlyAsnXGly (SEQ ID NO: 730). The second subgroup contains a characteristic, well-conserved motif around position 350 (GlyXXSerValProXXTrp)(SEQ ID NO: 731), whereas the other group contains proteins that are unrelated except for the presence of the common 180-residue PPE domain. C-terminal extensions may range in size from 00 up to 3500 residues.

One member of the PGRS sub-family, the WHO antigen 22T (Abou-Zeid et al., 1991), a 55 kD protein capable of binding fibronectin, is produced during disease and elicits a variable antibody response suggesting either that individuals mount different immune responses or that this PGRS-protein may not be produced in this form by all strains of M. tuberculosis. In other words, at least some PE_PGRS coding sequences encode for proteins that are involved in the recognition of M. tuberclosis by the immune system of the infected host Therefore, differences in the PGRS sequences could represent the principal source of antigenic variation in the otherwise genetically and antigenically homogeneous bacterium.

By performing the method of the invention using the M. tuberclosis BAC based DNA library I-1945, the inventors have discovered the occurence of sequence differences between a given PGRS encoding ORF (ORF reference on the genomic sequence of M. tuberclosis Rv0746) of M. tuberclosis and its counterpart sequence in the genome of M. bovis BCG.

More precisely, the inventors have determined that one ORF contained in BAC vector N Rv418 of the M. tuberclosis BCG I-1945 DNA library carries both base additions and base deletions when compared with the corresponding ORF in the genome of M. bovis BCG that is contained in the BAC vector N X0175 of the M. bovis BCG I-2049 DNA libary. The variations observed in the base sequences correspond to variations in the C-terminal part of the aminoacid sequence of the PGRS ORF translation product.

As shown in FIG. 6, an amino acid stretch of 29 residues in length is present in this M. tuberclosis PGRS (ORf reference Rv0746) and is absent from the ORF counterpart of M. bovis BCG, namely the following amino acid sequence:

NH₂-GGAGGAGGSSAGGGGAGGAGGAGGWLLGD-COOH (SEQ ID NO: 732).

Furthermore , FIG. 6 shows also that an amino acid stretch of 45 residues in length is absent from this M. tuberclosis PGRS and is present in the ORF counterpart of M. bovis BCG, namely following amino acid sequence:

NH₂-GAGGIGGIGGNANGGAGGNGGTGGQLWGSGGAGVEGGAALSVGDT-COOH (SEQ ID NO: 733).

Similar observations were made with PPE ORF Rv0442, which showed a 5 codon deletion relative to a M. bovis amino acid sequence.

Given that the polymorphism associated with the PE-PGRS or PEE ORFS resulted in extensive antigenic variability or reduced antigen presentation, this would be of immense significance for vaccine design, for understanding protective immunity in tuberculosis and, possibly, explain the varied responses seen in different BCG vaccination programmes.

There are several striking parallels between the PGRS proteins and the Epstein-Barr virus-encoded nuclear antigens (EBNA). Both polypeptide families are glycine-rich, contain Gly-Ala repeats that represent more than one third of the molecule, and display variation in the length of the repeat region between different isolates. The Gly-Ala repeat region of EBNA1 has been shown to function as a cis-acting inhibitor of antigen processing and MHC class I-restricted antigen presentation (Levitskaya et al., 1995). The fact that MHC class I knock-out mice are extremely suscepible to M. tuberclosis underlines the importance of MHC class I antigen presentation in protection against tuberculosis. Therefore, it is possible that the PE/PPE protein family also play some role in inhibiting antigen presentation, allowing the bacillus to hide from the host's immune system.

As such the novel and nonobvious PGRS polynucleotide from M. bovis which is homolog to the M. tuberclosis ORF Rv0746, and which is contained in the BAC clone N X0175 (See Table 4 for SP6 and T7 endsequences of clone n^(o) X0175) of the I-2049 M. bovis BCG BAC DNA library is part of the present invention, as it represents a starting material in order to define specific probes or primers usefill for detection of antigenic variability in mycobacterial strains, possible inhibition of antigen processing as well as to differentiate M. tuberculosis from M. bovis BCG.

Thus, a further object of the invention consists in a polynucleotide comprising the following sequence SEQ ID N^(o)4:

CCGACCCAGA CACTGACCGG GCGACCGCTG ATCGGCAACG GCACCCCCGG GGCGGTCGGC  60 AGCGGGGCCA CCGGGGCCCC CGGTGGGTGG CTGCTCGGCG ACGGCGGGGC CGGCGGGTCC 120 GGCGCGGCGG GCTCGGGCGC GCCCGGCGGG GCGGGCGGGG CTGCCGGGCT GTGGGGTACC 180 GGCGGGGCCG GCGGGATCGG CGGAGCCAGC ACCGTACTCG GCGGCACCGG CGGGGGAGGC 240 GGGGTCGGTG GGCTGTGGGG CGCCGGTGGG GCCGGCGGGG CCGGTGGAAC CGGCCTTGTT 300 GGTGGCGACG GCGGGGCCGG TGGGGCCGGC GGGACCGGCG GACTGCTGGC CGGGCTGATC 360 GGTGCCGGCG GAGGTCACGG CGGGACCGGC GGGCTCAGCA CTAATGGCGA CGGCGGGGTT 420 GGCGGGGCCG GCGGGAATGC CGGAATGCTC GCCGGGCCGG GCGGCGCCGG CGGAGCCGGC 480 GGTGACGGCG AAAACCTGGA CACCGGTGGG GACGGCGGGG CCGGCGGTAG CGCAGGGCTG 540 CTGTTCGGCA GCGGCGGCGC CGGCGGCGCC GGCGGATTTG GTTTCCTCGG TGGGGACGGC 600 GGGGCCGGTG GCAACGCCGG GCTGCTGTTG TCCAGCGGCG GGGCCGGCGG GTTCGGCGGG 660 TTCGGCACCG CCGGTGGGGT CGGTGGGGCC GGCGGCAATG CCGGCTGGCT GGGCTTCGGC 720 GGGGCCGGGG GCATCGGCGG AATCGGCGGT AACGCTAACG GGGGCGCCGG TGGGAACGGC 780 GGCACCGGCG GTCAGTTATG GGGTAGCGGC GGCGCCGGCG TCGAAGGCGG CGCAGCCTTA 840 AGCGTCGGCG ACACCGGCGG GGCCGGTGGC GTCGGCGGCA GCGCCGGGCT GATCGGCACC 900 GGCGGCAACG GCGGCAACGG CGGCACCGGC GCCAACGCCG GCAGCCCCGG AACCGGCGGC 960 GCCGGCGGGT TGCTGCTGGG CCAAAACGGG CTCAACGGGT TGCCGTAGCC GGGCGGCACG 1020  GCATGGCTTC CGGGCGTCAA CCACTCGCCG GTGATGCAGA TCGGCTGCGG AGCGGGCCGC 1080  CAAAATGGGG GCCGCCGCGC CAGGTATCTC GGCGAAGATC CCCGGCGCTC GAGCGCTTTG 1140  TCAGAGGCCC GTCGCGGGTC GTCGTGACGA CGGCTATCCG GGCGGTGCGG GTTTCGCGGC 1200  GCGCCCTGTG CCCGGCACCG CCGCCCGTTT GTCGGCAACG CCGCCGCGAC CCGTGAGCCG 1260  TCCAGCAGCT GGCGCCTGCG 1280 

Polynucleotides of interest have been defined by the inventors as useful detection tools in order to differentiate M. tuberclosis from M. bovis BCG. Such polynucleotides are contained in the 45 aminoacid length coding sequence that is present in M. bovis BCG but absent from M. tuberclosis. This polynucleotide has a sequence beginning (5′ end) at the nucleotide at position nt 729 of the sequence SEQ ID N^(o)4 and ending (3′ end) at the nucleotide in position nt 863 of the sequence SEQ ID N^(o)4.

Thus, part of the present invention is also a polynucleotide which is chosen among the following group of polynucleotides:

a) A polynucleotide comprising at least 8 consecutive nucleotides the following nucleotide sequence SEQ ID N^(o)5:

GGGCATCGGC GGAATCGGCG GTAACGCTAA CGGGGGCGCC GGTGGGAACG GCGGCACCGG  60 CGGTCAGTTA TGGGGTAGCG GCGGCGCCGG CGTCGAAGGC GGCGCAGCCT TAAGCGTCGG 120 CGACACC 127

b) A polynucleotide which sequence is fully complementary to the sequence of the polynucleotide defined in a);

c) A polynucleotide that hybridizes under stringent hybridization conditions with the polynucleotide defined in a) or with the polynucleotide defined in b).

The stringent hybridization conditions for the purpose of defining the above disclosed polynucleotide are defined herein before in the specification.

The invention also provides for a BAC-based Mycobacterium tuberculosis strain H37Rv genomic DNA library that has been deposited in the Collection Nationale de Cultures de Microorganismes on Nov. 19, 1997 under the accession number I-1945.

A further object of the invention consists in a recombinant BAC vector which is choosen among the group consisting of the recombinant BAC vectors belonging to the BAC-based DNA library I-1945.

Generally, a recombinant BAC vector of interest may be choosen among the following set or group of BAC vectors contained in the BAC-based DNA library I-1945: Rv101; Rv102; Rv103; Rv104; Rv105; Rv106; Rv107; Rv108; Rv109; Rv10; Rv110; Rv111; Rv112; Rv113; Rv114; Rv115; Rv116; Rv117; Rv118; Rv119; Rv11; Rv120; Rv121; Rv122; Rv123; Rv124; Rv126; Rv127; Rv128; Rv129; Rv130; Rv132; Rv134; Rv135; Rv136; Rv137; Rv138; Rv139; Rv13; Rv140; Rv141; Rv142; Rv143; Rv144; Rv145; Rv146; Rv147; Rv148; Rv149; Rv14; Rv150; Rv151; Rv152; Rv153; Rv154; Rv155; Rv156; Rv157; Rv159; Rv15; Rv160; Rv161; Rv162; Rv163; Rv164; Rv165; Rv166; Rv167; Rv169; Rv16; Rv170; Rv171; Rv172; Rv173; Rv174; Rv175; Rv176; Rv177; Rv178; Rv179; Rv17; Rv180; Rv181; Rv182; Rv183; Rv184; Rv185; Rv186; Rv187; Rv188; Rv18; Rv190; Rv191; Rv192; Rv193; Rv194; Rv195; Rv196; Rv19; Rv1; Rv201; Rv204; Rv205; Rv207; Rv209; Rv20; Rv214; Rv215; Rv217; Rv218; Rv219; Rv21; Rv220; Rv221; Rv222; Rv223; Rv224; Rv225; Rv226; Rv227; Rv228; Rv229; Rv22; Rv230; Rv231; Rv232; Rv233; Rv234; Rv235; Rv237; Rv240; Rv241; Rv243; Rv244; Rv245; Rv246; Rv247; Rv249; Rv24; Rv251; Rv252; Rv253; Rv254; Rv255; Rv257; Rv258; Rv259; Rv25; Rv260; Rv261; Rv262; Rv263; Rv264; Rv265; Rv266; Rv267; Rv268; Rv269; Rv26; Rv270; Rv271; Rv272; Rv273; Rv274; Rv275; Rv276; Rv277; Rv278; Rv279; Rv27; Rv280; Rv281; Rv282; Rv283; Rv284; Rv285; Rv286; Rv287; Rv288; Rv289; Rv28; Rv290; Rv291; Rv292; Rv293; Rv294; Rv295; Rv296; Rv29; Rv2; Rv301; Rv302; Rv303; Rv304; Rv306; Rv307; Rv308; Rv309; Rv30; Rv310; Rv311; Rv312; Rv313; Rv3l4; Rv315; Rv316; Rv317; Rv318; Rv319; Rv31; Rv32; Rv322; Rv327; Rv328; Rv329; Rv32; Rv330; Rv331; Rv333; Rv334; Rv335; Rv336; Rv337; Rv338; Rv339; Rv33; Rv340; Rv341; Rv343; Rv344; Rv346; Rv347; Rv348; Rv349; Rv34; Rv350; Rv351; Rv352; Rv353; Rv354; Rv355; Rv356; Rv357; Rv358; Rv359; Rv35; Rv360; Rv361; Rv363; Rv364; Rv365; Rv366; Rv367; Rv368; Rv369; Rv36; Rv370; Rv371; Rv373; Rv374; Rv375; Rv376; Rv377; Rv378; Rv379; Rv37; Rv381; Rv382; Rv383; Rv384; Rv385; Rv386; Rv387; Rv388; Rv389; Rv38; Rv390; Rv391; Rv392; Rv393; Rv396; Rv39; Rv3; Rv40; Rv42; Rv413; Rv414; Rv415; Rv416; Rv417; Rv418; Rv419; Rv41; Rv42; Rv43; Rv45; Rv46; Rv47; Rv48; Rv49; Rv4; Rv50; Rv51; Rv52; Rv53; Rv54; Rv55; Rv57; Rv58; Rv59; Rv5; Rv60; Rv61; Rv62; Rv63; Rv64; Rv65; Rv66; Rv67; Rv69; Rv6; Rv70; Rv71; Rv72; Rv73; Rv74; Rv75; Rv76; Rv77; Rv78; Rv79; Rv80; Rv81; Rv82; Rv83; Rv84; Rv85; Rv86; Rv87; Rv88; Rv89; Rv8; Rv90; Rv92; Rv94; Rv95; Rv96; Rv9.

The end sequences of the polynucleotide inserts of each of the above clones corresponding respectively to the sequences adjacent to the T7 promoter and to the Sp6 promoter on the BAC vector are shown in Table 3.

It has been shown by the inventors that the minimal overlapping set of BAC vectors of the BAC-based DNA library I-1945 contains 68 unique BAC clones and practically spans almost the whole H37Rv chromosome with the exception of a single gap of approximately 150 kb.

More specifically, a recombinant BAC vector of interest is choosen among the following set or group of BAC vectors from the BAC-based DNA library I-1945, the location of which vector DNA inserts on the chromosome of M. tuberclosis is shown in FIG. 3: Rv234; Rv351, Rv166; Rv35; Rv415; Rv404; Rv209; Rv272; Rv30; Rv228; Rv233; Rb38; Rv280; Rv177; Rv48; Rv374; Rv151; Rv238; Rv156; Rv92; Rv3; Rv403; Rv322; Rv243; Rv330; Rv285; Rv233; Rv219; Rv416; Rv67; Rv222; Rv149; Rv279; Rv87; Rv273; Rv266; Rv25; Rv136; Rv4l4; Rv13; Rv289; Rv60; Rv104; Rv5; Rv165; Rv215; Rv329; Rv240; Rv19; Rv74; Rv411; Rv167; Rv56; Rv80; Rv164; Rv59; Rv313; Rv265; Rv308; Rv220; Rv258; Rv339; Rv121; Rv419; Rv418; Rv45; Rv217; Rv134; Rv17; Rv103; Rv21; Rv22; Rv2; Rv270; Rv267; Rv174; Rv257; Rv44; Rv71; Rv7; Rv27; Rv191; Rv230; Rv128; Rv407; Rv106; Rv39; Rv255; Rv74; Rv355; Rv268; Rv58; Rv173; Rv264; Rv417; Rv401; Rv144; Rv302; Rv81; Rv163; Rv281; Rv221; Rv420; Rv175; Rv86; Rv412; Rv73; Rv269; Rv214; Rv287; Rv42; Rv143.

The polynucleotides disclosed in Table 3 may be used as probes in order to select a given clone of the BAC DNA library I-1945 for further use.

The invention also provides for a BAC-based Mycobacterium bovis strain Pasteur genornic DNA library that has been deposited in the Collection Nationale de Cultures de Microorganismes on Jun. 30, 1998 under the accession number I-2049.

A further object of the invention consists in a recombinant BAC vector which is chosen among the group consisting of the recombinant BAC vectors belonging to the BAC-based DNA library I-2049. This DNA library contains approximately 1600 clones. The average insert size is estimated to be 80 kb.

Generally, a recombinant BAC vector of interest may be chosen among the following set or group of BAC vectors contained in the BAC-based DNA library I-2049: X0001; X0002; X0003; X0004; X0006; X0007; X0008; X0009; X0010; X0012; X0013; X0014; X0015; X0016; X0017; X0018; X0019; X0020; X0021; X0175.

The end sequences of the polynucleotide inserts of each of the above clones corresponding respectively to the sequences adjacent to the T7 promoter and to the Sp6 promoter on the BAC vector are shown in Table 4.

The polynucleotides disclosed in Table 4 may be used as probes in order to select a given clone of the BAC DNA library I-2049 for further use.

Are also part of the invention the polynucleotide inserts that are contained in the above described BAC vectors, that are useful as primers or probes.

These polynucleotides and nucleic acid fragments may be used as primers for use in amplification reactions, or as nucleic probes.

PCR is described in the U.S. Pat. No. 4,683,202. The amplified fragments may be identified by an agarose or a polyacrylamide gel electrophoresis, or by a capillary electrophoresis or alternatively by a chromatography technique (gel filtration, hydrophobic chromatography or ion exchange chromatography). The specificity of the amplification may be ensured by a molecular hybridization using, for example, one of the initial primers as nucleic probes.

Amplified nucleotide fragments are used as probes in hybridization reactions in order to detect the presence of one polynucleotide according to the present invention or in order to detect mutations in the genome of the given mycobacterium of interest, specifically a mycobacterium belonging to the Mycobacterium tuberculosis complex and more specifically Mycobacterium tuberculosis and Mycobacterium bovis BCG.

Are also part of the present invention the amplified nucleic fragments (<<amplicons>>) defined herein above.

These probes and amplicons may be radioactively or non-radioactively labeled, using for example enzymes or fluorescent compounds.

Other techniques related to nucleic acid amplification may also be used and are generally preferred to the PCR technique.

The Strand Displacement Amplification (SDA) technique (Walker et al., 1992) is an isothermal amplification technique based on the ability of a restriction enzyme to cleave one of the strands at his recogntion site (which is under a hemiphosphorothioate form) and on the property of a DNA polymerase to initiate the synthesis of a new strand from the 3′OH end generated by the restriction enzyme and on the property of this DNA polymerase to displace the previously synthesized strand being localized downstream. The SDA method comprises two main steps:

a) The synthesis, in the presence of dCTP-alpha-S, of DNA molecules that are flanked by the restriction sites that may be cleaved by an appropriate enzyme.

b) The exponential amplification of these DNA molecules modified as such, by enzyme cleavage, strand displacement and copying of the displaced strands. The steps of cleavage , strand displacement and copy are repeated a sufficient number of times in order to obtain an accurate sensitivity of the assay.

The SDA technique was initially realized using the restriction endonuclease HindIII but is now generally practised with an endonuclease from Bacillus stearothermophilus (BSOBI) and a fragment of a DNA polymerase which is devoid of any 5′3′exonuclease activity isolated from Bacilllus cladotenox (exo-Bca) [=exo-minus-Bca]. Both enzymes are able to operate at 60° C. and the system is now optimized in order to allow the use of dUTP and the decontamination by UDG. When unsing this technique, as described by Spargo et al. in 1996, the doubling time of the target DNA is of 26 seconds and the amplification rate is of 10¹⁰ after an incubation time of 15 min at 60° C.

The SDA amplification technique is more easy to perform than PCR (a single thermostated waterbath device is necessary) and is faster that the other amplification methods.

Thus, another object of the present invention consists in using the nucleic acid fragments according to the invention (primers) in a method of DNA or RNA amplification according to the SDA technique. For performing SDA, two pairs of primers are used: a pair of external primers (B1, B2) consisting of a sequence specific for the target polynucleotide of interest and a pair of internal primers (S1, S2) consisting of a fusion oligonucleotide carrying a site that is recognized by a restriction endonuclease, for example the enzyme BSOBI.

The operating conditions to perform SDA with such primers are described in Spargo et al, 1996.

The polynucleotides of the invention and their above described fragments, especially the primers according to the invention, are useful as technical means for performing different target nucleic acid amplification methods such as:

TAS (Transcription-based Amplification System), described by Kwoh et al. in 1989;

SR (Self-Sustained Sequence Replication), described by Guatelli et al. in 1990.

NASBA (Nucleic acid Sequence Based Amplification), described by Kievitis et al. in 1991.

TMA (Transcription Mediated Amplification).

The polynucleotides according to the invention are also useful as technical means for performing methods for amplification or modification of a nucleic acid used as a probe, such as:

LCR (Ligase Chain Reaction), described by Landegren et al. in 1988 and improved by Barany et al. in 1991 who employ a thermostable ligase.

RCR (Repair Chain Reaction) described by Segev et al. in 1992.

CPR (Cycling Probe Reaction), described by Duck et al. in 1990.

Q-beta replicase reaction, described by Miele et al. in 1983 and improved by Chu et al. in 1986, Lizardi et al. in 1988 and by Burg et al. and Stone et al. in 1996.

When the target polynucleotide to be detected is a RNA, for example a mRNA, a reverse transcriptase enzyme will be used before the amplification reaction in order to obtain a cDNA from the RNA contained in the biological sample. The generated cDNA is subsequently used as the nucleic acid target for the primers or the probes used in an amplification process or a detection process according to the present invention.

The non-labeled polynucleotides or oligonucleotides of the invention may be directly used as probes. Nevertheless, the polynucleotides or oligonucleotides are generally labeled with a radioactive element (³²P, ³⁵S, ³H, ¹²⁵I or by a non-isotopic molecule (for example, biotin, acetylaminofluorene, digoxigenin, 5-bromodesoxyuridin, fluorescein) in order to generate probes that are useful for numerous applications.

Examples of non-radioactive labeling of nucleic acid fragments are described in the french patent N^(o) FR-7810975 or by Urdea et al. or Sanchez-Pescador et al., 1988.

In the latter case, other labeling techniques may be also used such as those described in the french patents FR-2,422,956 and 2,518,755. The hybridization step may be performed in diffrent ways (Matthews et al., 1988). The more general method consists of immobilizing the nucleic acid that has been extracted from the biological sample onto a substrate (nitrocellulose, nylon, polystyrene) and then to incubate, in defined conditions, the target nucleic acid with the probe. Subsequently to the hybridization step, the excess amount of the specific probe is discarded and the hybrid molecules formed are detected by an appropriate method (radioactivity, fluorescence or enzyme activity measurement).

Advantageously, the probes according to the present invention may have structural characteristics such that they allow the signal amplification, such structural characteristics being, for example, branched DNA probes as those described by Urdea et al. in 1991 or in the European patent N^(o) EP-0225,807 (Chiron).

In another advantageous embodiment of the probes according to the present invention, the latters may be used as <<capture probes>>, and are for this purpose immobilized on a substrate in order to capture the target nucleic acid contained in a biological sample. The captured target nucleic acid is subsequently detected with a second probe which recognizes a sequence of the target nucleic acid which is different from the sequence recognized by the capture probe.

The oligonucleotide probes according to the present invention may also be used in a detection device comprising a matrix library of probes immobilized on a substrate, the sequence of each probe of a given length being localized in a shift of one or several bases, one from the other, each probe of the matrix library thus being complementary to a distinct sequence of the target nucleic acid. Optionally, the substrate of the matrix may be a material able to act as an electron donor, the detection of the matrix poisitons in which an hybridization has occurred being subsequently determined by an electronic device. Such matrix libraries of probes and methods of specific detection of a targer nucleic acid is described in the European patent application N^(o) EP-0713,016 (Affymax technologies) and also in the U.S. Pat. No. 5,202,231 (Drmanac).

Since almost the whole length of a mycobacterial chromososme is covered by a BAC-based genomic DNA libraries according to the present invention (i.e. 97% of the M. tuberculosis chromosome is covered by the BAC library I-1945), these DNA libraries will play an important role in a plurality of post-genomic applications, such as in mycobacterial gene expression studies where the canonical set of BACs could be used as a matrix for hybridization studies. Probing such matrices with cDNA probes prepared from total mRNA will uncover genetic loci induced or repressed under different physiological conditions (Chuang et al., 1993; Trieselmann et al., 1992). As such, the H37Rv BAC library represents a fundamental resource for present and future genomics investigations.

The BAC vectors or the polynucleotide inserts contained therein may be directly used as probes, for example when immobilized on a substrate such as described herein before.

The BAC vectors or their polynucleotide inserts may be directly asdorbed on a nitrocellulose membrane, at predetermined locations on which one or several polynucleotides to be tested are then put to hybridize therewith.

Preferably, a collection of BAC vectors that spans the whole genome of the mycobacteriurn under testing will be immobilized, such as, for example, the set of 68 BAC vectors of the I-1945 DNA library that is described elsewhere in the specification and shown in FIG. 3.

The immobilization and hybridization steps may be performed as described in the present Materials and Methods Section.

As another illustrative embodiment of the use of the BAC vectors of the invention as polynucleotide probes, these vectors may be useful to perform a transcriptional activity analysis of mycobacteria growing in different environmental conditions, for example under conditions in which a stress response is expected, as it is the case at an elevated temperature, for example 40° C.

In this specific embodiment of the invention, Genescreen membranes may be used to immobilize the restriction endonuclease digests (HindIII digests for the BAC DNA library I-1945) of the BAC vectors by tranfer from a gel (Trieselmann et al., 1992).

Alternatively, the BAC vectors may be immobilized for dot blot experiments as follows. First, the DNA concentration of each BAC clone is determined by hybridization of blots of clone DNAs and of a BAC vector concentration standard with a BAC vector specific DNA probe. Hybridization is quantified by the Betascope 603 blot analyzer (Betagen Corp.), which colects beta particles directly from the blot with high efficiency. Then, 0.5 μg of each clone DNA is incubated in 0.25 M NaOH and 10 mM EDTA at 65° C. for 60 min to denature the DNA and degrade residual RNA contaminants. By using a manifold filtration system (21 by 21 wells), each clone DNA is blotted onto a GeneScreen Plus nylon membrane in the alkaline solution. After neutralization, the blots are baked at 85° C. for 2 h under vacuum. Positive and negative controls are added when necessary. In order to perform this procedure, it may be referred to the article of Chuang et al. (1993).

For RNA extractions, cells grown in a suitable volume of culture medium may, for example, be immediately mixed with an equal volume of crushed ice at −70° C. and spun at 4° C. in a 50 ml centrifugation tube. The cell pellet is then suspended in 0.6 ml of ice-cold buffer (10 mM KCl, 5 mM MgCl, 10 mM Tris; pH 7.4) and then immediately added to 0.6 ml of hot lysis buffer (0.4 M NaCl, 40 mM EDTA, 1% beta-mercaptoethanol, 1% SDS, 20 mM Tris; pH 7.4) containing 100 μl of water saturated phenol. This mixture is incubated in a boiling water bath for 40 s. The debris are removed by centrifugation. The supernatant is extracted with phenol-chloroform five times, ethanol precipitated, and dried. The dried RNA pellet is dissolved in water before use.

Then labeled total cDNA may be prepared by the following method. The reaction mixture contains 15 μg of the previously prepared total RNA, 5 μg of pd(N₆) (random hexamers from Pharmacia Inc.), 0.5 mM DATP, 0.5 mM dGTP and 0.5 mM DTTP, 5 μM dCTP, 100 μCi of [α-³²P]dCTP (3,000 Ci/mmol), 50 mM Tris-HCl (pH 8.3), 6 mM MgCl₂, 40 mM Kcl, 0.5 U of avian myeloblastosis virus reverse transcriptase (Life Science Inc.) in a total volume of 50 μl. The reaction is allowed to continue overnight at room temperature. EDTA and NaOH are then added to final concentrations of 50 mM and 0.25 M, respectively, and the mixture is incubated at 65° C. for 30 min to degrade the RNA templates. The cDNA is then ready to use after neutralization by adding Hcl and Tris buffer.

The hybridization step may be performed as described by Chuang et al. (1993) and briefly disclosed hereinafter. The DNA dot blot is hybridized to ³²P-labeled total cDNA in a solution containing 0.1% polyvinylpyrrolidone, 0.1% Ficoll, 0.1% sodium Pp_(i), 0.1% bovine serum albumin, 0.5% SDS, 100 mM NaCl, and 0.1 mM sodium citrate, pH 7.2, at 65° C. for 2 days and then washed with a solution containing 0.1% SDS, 100 mM NaCl, and 10 mM Na-citrate, pH 7.2. The same dot blot is used for hybridization with both control and experimental cDNAs, with an alkaline probe stripping procedure (soaked twice in 0.25M NaOH-0.75 M NaCl at room temperature, 30 min each, neutralized, and completely dried at 65° C. for at least 30 min) between the two hybridizations. Quantification may be done with the Betascope 603 blot analyzer (Betagen Corp.).

As it flows from the above technical teachings, another object of the invention consists in a method for detecting the presence of mycobateria in a biological sample comprising the steps of:

a) bringing into contact the recombinant BAC vector or a purified polynucleotide according to the invention with a biological sample.

b) detecting the hybrid nucleic acid molecule formed between said purified polynucleotide and the nucleic acid molecules contained within the biological sample.

The invention further deals with a method for detecting the presence of mycobacteria in a biological sample comprising the steps of:

a) Bringing into contact the recombinant BAC vector or a purified polynucleotide according to the invention that has been immobilized onto a substrate with a biological sample.

b) Bringing into contact the hybrid nucleic acid molecule formed between said purified polynucleotide and the nucleic acid contained in the biological sample with a labeled recombinant BAC vector or a polynucleotide according to the invention, provided that said polynucleotide and polynucleotide of step a) have non-overlapping sequences.

Another object of the invention consists in a method for detecting the presence of mycobacteria in a biological sample comprising the steps of:

a) Bringing into contact the nucleic acid molecules contained in the biological sample with a pair of primers according to the invention.

b) Amplifying said nucleic acid molecules;

d) detecting the nucleic acid fragments that have been amplified, for example by gel electrophoresis or with a labeled polynucleotide according to the invention.

In one specific embodiment of the above detection and/or amplification methods, said methods comprise an additional step wherein before step a), the nucleic acid molecules of the biological sample have been made available to a hybridization reaction.

In another specific embodiment of the above detection methods, said methods comprise an additional step, wherein, before the detection step, the nucleic acid molecules that are not hybridized with the immobilized purified polynucleotide are removed.

Also part of the invention is a kit for detecting mycobacteria in a biological sample comprising:

a) A recombinant BAC vector or a purified polynucleotide according to the invention;

b) Reagents necessary to perform a nucleic acid hybridization reaction.

The invention also pertains to a kit for detecting a mycobacteria in a biological sample comprising:

a) A recombinant BAC vector or a purified polynucleotide according to the invention that is immobilized onto a substrate.

b) Reagents necessary to perform a nucleic acid hybridization reaction.

c) A purified polynucleotide according to the invention which is radioactively or non-radioactively labeled, provided that said polynucleotide and the polynucleotide of step a) have non-overlapping sequences.

Moreover, the invention provides for a kit for detecting mycobacteria in a biological sample comprising:

a) A pair of purified primers according to the invention;

b) Reagents necessary to perform a nucleic acid amplification reaction;

c) Optionally, a purified polynucleotide according to the invention useful as a probe.

The invention embraces also a method for detecting the presence of a genomic DNA, a cDNA or a mRNA of mycobacteria in a biological sample, comprising the steps of:

a) Bringing into contact the biological sample with a plurality of BAC vectors according to the invention or purified polynucleotides according to the invention, that are immobilized on a substrate;

b) Detecting the hybrid complexes formed.

The invention also provides a kit for detecting the presence of genomic DNA, cDNA or mRNA of a mycobacterium in a biological sample, comprising:

a) A substrate on which a plurality of BAC vectors according to the invention or purified polynucleotides according to the invention have been immobilized;

b) Optionally, the reagents necessary to perform the hybridization reaction.

Additionally, the recombinant BAC vectors according to the invention and the polynucleotide inserts contained therein may be used for performing detection methods based on <<molecular combing>>. Said methods consist in methods for aligning macromolecules, especially DNA and are applied to processes for detecting, for measuring intramolecular distance, for separating and/or for assaying a macromolecule, especially DNA in a sample.

These <<molecular combing>> methods are simple methods, where the triple line S/A/B (meniscus) resulting form the contact between a solvent A and the surface S and a medium B is caused to move on the said surface S, the said macromolecules (i.e. DNA) having a part, especially an end, anchored on the surface S, the other part, especially the other end, being in solution in the solvent A. These methods are particularly fully described in the PCT Application n^(o) PCT/FR 95/00165 files on Feb. 11, 1994 (Bensimon et al.).

When performing the <<molecular combing>> method with the recombinant BAC vectors according to the inventions or their polynucleotide inserts, the latters may be immobilized (<<anchored>>) on a suitable substrate and aligned as described in the PCT Application No. PCT/FR 95/00165, the whole teachings of this PCT Application being herein incorporated by reference. Then, polynucleotides to be tested, preferably under the form of radioactively or non radioactively labeled polynucleotides, that may consist of fragments of genomic DNA, cDNA etc. are brought into contact with the previously aligned polynucleotides according to the present invention and then their hybridization position on the aligned DNA molecules is determined using any suitable means including a microscope or a suitable camera device.

Thus, the present invention is also directed to a method for the detection of the presence of a polynucleotide of mycobacterial origin in a biological sample and/or for physical mapping of a polynucleotide on a genomic DNA, said method comprising:

a) Aligning at least one polynucleotide contained in a recombinant BAC vector according to the invention on the surface of a substrate;

b) Bringing into contact at least one polynucleotide to be tested with the substrate on which the at least one polynucleotide of step a) has been aligned;

c) detecting the presence and/or the location of the tested polynucleotide on the at least one aligned polynucleotide of step a).

The invention finally provides for a kit for performing the above method, comprising:

a) a substrate whose surface has at least one polynucleotide contained in a recombinant BAC vector according to the invention,

b) optionally, reagents necessary for labeling DNA;

c) optionally, reagents necessary for performing a hybridization reaction.

In conclusion, it may be underlined that the alliance of such BAC-based approaches such as described in the present specification to the advances in comparative genomics by the availability of an increased number of complete genomes, and the rapid increase of well-characterized gene products in the public databases, will allow the one skilled in the art an exhaustive analysis of the mycobacterial genome.

MATERIALS AND METHODS

1. DNA-preparation. Preparation of M. tuberclosis H37Rv DNA in agarose plugs was conducted as previously described (Canard et al., 1989; Philipp et al., 1996b). Plugs were stored in 0.2 M EDTA at 4 C and washed 3 times in 0.1% Triton X-100 buffer prior to use.

2. BAC vector preparation. pBeloBAC11 was kindly provided by Dr. Shizuya, Department of Biology, California Institute of Technology (Pasadena, Calif.). The preparation followed the description of Woo et al., 1994 (Woo et al., 1994).

3. Partial digestion with HindIII. Partial digestion was carried out on plugs, each containing approximately 10 μg of high molecular weight DNA, after three one hour equilibration steps in 50 ml of HindIII 1×digestion buffer (Boehringer Mannheim, Mannheim, Germany) plus 0.1% Triton X-100. The buffer was then removed and replaced by imliplug of ice-cold HindIII enzyme buffer containing 20 units of HindIII (Boehringer). After two hours incubation on ice, the plugs were transferred to a 37° C. water bath for 30 minutes. Digestions were stopped by adding 500 μl of 50 mM EDTA (pH 8.0).

4. Size selection. The partially digested DNA was subjected to contour-clamped homogenous electric field (CHEF) electrophoresis on a 1% agarose gel using a BioRad DR III apparatus (BioRad, Hercules, Calif.) in 1×TAE buffer at 13° C., with a ramp from 3 to 15 seconds at 6 V/cm for 16 hours. Agarose slices from 25 to 75 kb, 75 to 120 kb and 120 to 180 kb were excised from the gel and stored in TE at 4° C.

5. Ligation and transformation. Agarose-slices containing fractions from 25 to 75 kb, 75 to 120 kb and 120 to 180 kb were melted at 65° C. for 10 minutes and digested with Gelase (Epicentre Technologies, Madison, Wis.), using 1 unit per 100 μl gel-slice. 25-100 ng of the size-selected DNA was then ligated to 10 ng of HindIII digested, dephosphorylated pBeloBAC11 in a 1:10 molar ratio using 10 units of T4 DNA ligase (New England Biolabs, Beverly, Mass.) at 16° C. for 20 hours. Ligation mixtures were heated at 65° C. for 15 minutes, then drop-dialysed against TE using Millipore VS 0.025 mM membranes (Millipore, Bedford, Mass.). Fresh electrocompetent E. coli DH 10B cells (Sheng et al., 1995) were harvested from 200 ml of a mid-log (OD₅₅₀=0.5) culture grown in SOB medium. Cells were washed three times in ice-cold water, and finally resuspended in ice-cold water to a cell density of 10¹¹ cells/ml (OD₅₅₀=150). 1 μl of the ligation-mix was used for electroporation of 30 μl of electrocompetent DH10B E. coli using a Eurogentec Easyject Plus electroporator (Eurogentec, Seraing, Belgium), with settings of 2.5 kV, 25 μF, and 99 ½, in 2 mm wide electroporation cuvettes. After electroporation, cells were resuspended in 600 μl of SOC medium, allowed to recover for 45 minutes at 37° C. with gentle shaking, and then plated on LB agar containing 12.5 μg/ml chloramphenicol (CM), 50 μg/ml X-gal, and 25 μg/ml IPTG. The plates were incubated overnight and recombinants (white colonies) were picked manually to 96 well plates. Each clone was inoculated 3 times (2×200 μl and 1×100 μl of 2YT/12.5 μg/ml CM per clone) and incubated overnight. One of the microtiter plates, containing 100 μl culture per well, was maintained as a master plate at −80° C. after 100 ml of 80% glycerol were added to each well, while minipreps (Sambrook et al., 1989) were prepared from the remaining two plates to check for the presence of inserts. Clones containing inserts were then designated “Rv” clones, repicked from the master plate to a second set of plates for storage of the library at −80° C.

6. Preparation of DNA for sizing, direct sequencing and comparative genomics. A modified Bimboim and Doly protocol (Birnboim et al., 1979) was used for extraction of plasmid DNA for sequencing purposes. Each Rv clone was inoculated into a 50 ml Falcon polypropylene tube containing 40 ml of 2YT medium with 12.5 μg/ml of CM and grown overnight at 37° C. with shaking. Cells were harvested by centrifugation and stored at −20° C. The frozen pellet was resuspended in 4 ml of Solution A (50 mM glucose, 10 mM EDTA, 25 mM Tris, pH 8.0) and 4 ml of freshly prepared solution B (0.2 M NaOH, 0.2% SDS) was then added. The solution was gently mixed and kept at room temperature for 5 minutes before adding 4 ml of ice-cold solution C (3M Sodium Acetate, pH 4.7). Tubes were kept on ice for 15 min, and centrifuged at 10,000 rpm for 15 min. After isopropanol precipitation, the DNA pellet was dissolved in 600 μl RNase solution (15 mM Tris HCl pH 8.0, 10 μg/ml RNase A). After 30 minutes at 37° C. the DNA solution was extracted with chloroform:isoarnylalcohol (24:1) and precipitated from the aqueous phase using isopropanol. The DNA pellet was then rinsed with 70% ethanol, air-dried and dissolved in 30 μl distilled water. In general, DNA prepared by this method was clean and concentrated enough to give good quality results by automatic sequencing (at least 300 bp of sequence). For a few DNA preparations, an additional polyethylene glycol (PEG) precipitation step was necessary, which was performed as follows. The 30 μl of DNA solution were diluted to 64 μl, mixed gently and precipitated using 16 μl 4M NaCl and 80 μl of 13% PEG 8000. After 30 min on ice the tubes were centrifuged at 4° C., the pellet carefully rinsed with 70% ethanol, air-dried and diluted in 20 μl of distilled water.

7. Sizing of inserts. Insert sizes were determined by pulsed-field gel electrophoresis (PFGE) after cleavage with Dral (Promega). 100-200 ng of DNA was Dral-cleaved in 20 μl total reaction volume, following the manufacturer's recommendations, then loaded onto a 1% agarose gel and migrated using a pulse of 4 s for 15 h at 6.25 V/cm at 10° C. on an LKB-Pharmacia CHEF apparatus. Mid-range and low-range PFGE markers (New England Biolabs) were used as size standards. Insert sizes were estimated after ethidium bromide staining of gels.

8. Direct sequencing. For each sequencing reaction 7 μl BAC DNA (300-500 ng), 2 μl primer (2 μM), 8 μl reaction mix of the Taq DyeDeoxy Terminator cycle sequencing kit (Applied Biosystems) and 30 μl distilled water were used. After 26 cycles (96° C. for 30 sec; 56° C. for 15 sec; 60° C. for 4 min) in a thermocycler (MJ-research Inc., Watertown, Mass.) DNA was precipitated using 70 μl of 70% ethanol/0.5 mM MgCl₂, centrifuged, rinsed with 70% ethanol, dried and dissolved in 2 μl of formamide/EDTA buffer. SP6 and T7 samples of 32 BAC clones were loaded onto 64 lane, 6% polyacrylamide gels and electrophoresis was performed on a Model 373A automatic DNA sequencer (Applied Biosystems) for 12 to 16 hours. The sequences of oligonucleotides used as primers are shown in Table 1.

9. DOP-PCR. As an alternate procedure we used partially degenerate oligonucleotides in combination with vector-specific (SP6 or T7) primers to amplify insert ends of BAC clones, following a previously published protocol for P1 clones (Liu et al., 1995). The degenerate primers Deg2, Deg3, Deg4, Deg6 (Table 1) gave the best results for selected amplification of insert termini.

TABLE 1 Primers used for PCRs and sequencing Vector specific Primers for DOP PCR-first amplification step: SP6-BAC1: AGT TAG CTC ACT CAT TAG GCA (SEQ ID NO: 734) T7-BAC1: GGA TGT GCT GCA AGG CGA TTA (SEQ ID NO: 735) Vector specific Primers (direct sequencing nested primer for second PCR step) SP6 Mid: AAA CAG CTA TGA CCA TGA TTA CGC CAA (SEQ ID NO: 736) T7-Belo2: TCC TCT AGA GTC GAC CTG CAG GCA (SEQ ID NO: 737) Degenerate Primers: Deg2: TCT AGA NNN NNN TCC GGC (SEQ ID NO: 738) Deg3: TCT AGA NNN NNN GGG CCC (SEQ ID NO: 739) Deg4: CGT TTA AAN NNN NWA GGC CG (SEQ ID NO: 740) Deg6: GGT ACT AGT NNN NNW TCC GGC (SEQ ID NO: 741) Primers used for the amplification of M. bovis DNA in polymorphic chromosomal region of Rv58: Primer 1: ACG ACC TCA TAT TCC GAA TCC C (SEQ ID NO: 742) Primer 2: GCA TCT GTT GAG TAC GCA CTT CC (SEQ ID NO: 743)

10. Screening by pooled PCR. To identify particular clones in the library which could not be detected by random end-sequencing of the 400 BAC clones, PCR-screening of DNA pools was performed. Primers were designed for regions of the chromosome where no BAC coverage was appearent using cosmid-or H37Rv whole genome shotgun sequences. Primers were designed to amplify approximately 400-500 bp. Ninety-six-well plates containing 200 μl 2YT/12.5 μg/ml CM per well were inoculated with 5 μl of −80° C. glycerol stock cultures each from the master plates and incubated overnight. The 96 clones of each plate were pooled by taking 20 μl of culture from each well and this procedure was repeated for 31 plates. Pooled cultures were centrifuged, the pellets were resuspended in sterile water, boiled for 5 minutes, centrifuged and the supernatants kept for PCRS. As an initial screening step, the 31 pools of a total of 2976 BACs, representing about two thirds of the library were tested for the presence of a specific clone using appropriate PCR primers. PCR was performed using 10 μl of supernatant, 5 μl of assay buffer (100 mM b-mercaptoethanol, 600 mM Tris HCl (pH 8.8), 20 mM MgCl₂, 170 mM (NH₄)₂SO₄), 5 μl of Dimethylsulfoxide (DMSO), 5 μl of dNTPs (20 mM), 5 μl of water, 10 μl primer (2 μM), 10 μl inverse primer (2 μM) and 0.2 units off aq DNA polymerase (Boehringer). 32 cycles of PCR (95° C. for 30 s, 55° C. for 1 min 30 s, 72° C. for 2 min) were performed after an initial denaturation at 95° C. 1 min. An extension step at 72° C. for 5 min finished the PCR. If a pool of 96 clones yielded an appropriate PCR product (FIG. 1A), subpools were made to identify the specific clone. Subpools representative for lane A of a 96 well plate were made by pooling clones 1 to 12 from lane A into a separate tube. Subpools for lanes B to H were made in the same way. In addition, subpools of each of the 12 rows (containing 8 clones each) were made, so that for one 96 well plate, 20 subpools were obtained. PCR with these 20 subpools identified the specific clone (FIG. 1B, lower gel portion). If more than one specific clone was present among the 96 clones of one plate (FIG. 1B, upper gel portion), additional PCR reactions had to be performed with the possible candidates (data not shown).

11. Genomic comparisons. DNA from the BAC clone Rv58 was digested with the restriction endonucleases EcoRI and PvuII, and resolved by agarose gel electrophoresis at low voltage overnight (1.5 V/cm). DNA was transferred via the method of Southern to nitrocellulose membranes (Hybond C extra, Amersham) following standard protocols (Sambrook et al., 1989), then fixed to the membranes at 80° C. for 2 hours. The blot was hybridized with ³²P labelled total genomic DNA from M. tuberclosis H37Rv, M. bovis type strain (ATCC 19210) or M. bovis BCG Pasteur. Hybridization was performed at 37° C. overnight in 50% formamide hybridization buffer as previously described (Philipp et al., 1996b). Results were interpreted from the autoradiograms.

12. Computer analysis. Sequence data from the automated sequencer ABI373A were transferred as binary data to a Digital Alpha 200 station or Sun SparcII station and analysed using TED, a sequence analysis program from the Staden software package (Dear et al., 1991). Proof-read sequences were compared using the BLAST programs (Altschul et al., 1990) to the M. tuberclosis H37Rv sequence databases of the Sanger Centre, containing the collected cosmid sequences (TB.dbs) and whole-genome shotgun reads (TB_shotgun_all.dbs) (http://www.sanger.ac.uk/). In addition, local databases containing 1520 cosmid endsequences and the accumulating BAC endsequences were used to determine the exact location of end-sequenced BACs on the physical and genetic map. MycDB (Bergh et al., 1994) and public databases (EMBL, Genbank) were also used to compare new sequences, but to a lesser extent. The organization of the open reading frames (ORFs) in the polymorphic region of clone Rv58 was determined using the DIANA software established at the Sanger Centre.

EXAMPLES

Example 1

Construction of a pBeloBAC11 Library of M. tuberclosis H37Rv.

Partial HindIII fragments of H37Rv DNA in the size range of 25 to 180 kb were ligated into pBeloBAC11 and electroporated into strain E. coli DH10B. While cloning of fractions I (25 to 75 kb) and II (75 to 120 kb) gave approximately 4×10⁴ transfornants (white colonies), cloning of fraction III (120 to 180 kb) repeatedly resulted in empty clones. Parallel cloning experiments using partial HindIII digests of human DNA resulted in stable inserts for all three fractions (data not shown), suggesting that the maximum size of large inserts in BAC clones is strongly dependent on the source of the DNA. Analysis of the clones for the presence of inserts revealed that 70% of the clones had an insert of the appropriate size while the remaining 30% of white colonies represented empty or lacZ′-mutated clones. Size determination of randomly selected, Dral-cleaved BACs via PFGE showed that the insert sizes ranged for the majority of the clones between 40 kb and 100 kb with an average size of 70 kb. Clones with inserts of appropriate size were designated with “Rv” numbers, recultured and stored at −80° C. for further use.

Example 2

Direct DNA Sequence Analysis of BACs.

To characterize the BAC clones, they were systematically subjected to insert termini sequencing. Two approaches, direct sequencing of BAC DNA and PCR with degenerate oligonucleotide primers (DOP), adapted to the high G+C content of mycobacterial DNA, were used. In a first screening phase, 50 BAC clones designated Rv1 to Rv50 were analysed using both methods in parallel. Except for two clones, where the sequences diverged significantly, the sequences obtained by the two methods only differed in length. Sequences obtained directly were on average about 350 bp long and for 95% of the clones both the SP6 and T7 endsequences were obtained at the first attempt. Sequences obtained by DOP-PCR were mostly shorter than 300 bp. For 40% of the BACs we obtained only very short amplicons of 50 to 100 base pairs from one end. In two cases the sequence obtained with the DOP-PCR differed from the sequences obtained by direct sequencing, and in these cases E. coli or vector sequences were amplified (data not shown). Taking the advantages and disadvantages of both methods into account, we decided to use direct termini sequencing for the systematic determination of the SP6 and T7 end-sequences.

Example 3

Representativity of the Library.

After having determined the end-sequences of 400 BACs a certain redundancy was seen. The majority of clones were represented at least 3 to 4 times. Maximum redundancy was seen in the vicinity of the unique ran operon, as 2.5% of the clones carried identical fragments that bridge the cosmids Y50 and Y130 (FIG. 3, approximate position at 1440 kb). The majority of clones with identical inserts appeared as two variants, corresponding to both possible orientations of the HindIII fragment in pBeloBAC11. This suggests that the redundancy was not the result of amplification during library construction, but due to the limited number of possible combinations of partial HindIII fragments in the given size-range of 25 to 120 kb. To detect rare BAC clones, a pooled PCR protocol was used. Primers were designed on the basis of the existing cosmid sequences and used to screen 31 pools of 96 BAC clones. When positive PCR products of the correct size were obtained, smaller subpools (of 8 or 12 clones each) of the corresponding pool were subsequently used to identify the corresponding clone (FIG. 1). With this approach 20 additional BACs (Rv401-Rv420) were found for the regions where no BACs were found with the initial systematic sequencing approach. The endsequences of these BACs (Rv401-420) were determined by direct sequencing, which confirmed the predicted location of the clones on the chromosome. A 97% coverage of the genome of H37Rv with BAC clones was obtained. Only one region of 150 kb was apparently not represented in the BAC library as screening of all pools with several sets of specific primers did not reveal the corresponding clone. This was probably due to the fact that HindIII fragments of mycobacterial DNA larger than 110 kb are very difficult to establish in E. coli and that a HindIII fragment of ˜120 kb is present in this region of the chromosome (data not shown).

Example 4

Establishing a BAC Map.

Using all endsequence and shotgun-sequence data from the H37Rv genome sequencing project, most of the BAC clones could then be localized by sequence comparison on the integrated map of the chromosome of M. tuberclosis strain H37Rv (Philipp et al., 1996b) and an ordered physical map of the BAC-clones was established. PCR with primers from the termini sequences of selected BACs were used for chromosomal walking and confirmation of overlapping BACs (data not shown). The correct order of BACs on the map was also confirmed more recently, using 40,000 whole genome shotgun reads established at the Sanger Centre. In addition, pulsed-field gel electrophoresis of Dral digests of selected BACs was performed (FIG. 2) in order to see if the approximate fragment size and the presence or absence of DraI cleavage sites in the insert were consistent with the location of the BACs on the physical map (FIG. 3). Comparison of the sequence-based BAC-map with the physical and genetic map, established by PFGE and hybridization experiments (Philipp et al., 1996b), showed that the two maps were in good agreement. The positions of 8 genetic markers previously shown on the physical and genetic map were directly confirmed by BAC-endsequence data (Table 2, FIG. 3). The position of 43 from 47 Y-clones (91%) shown on the physical and genetic map, which were later shotgun sequenced, was confirmed by the BAC endsequences and shotgun sequence data. Four clones (Y63, Y180, Y251, and Y253) were located to different positions than previously thought and this was found to be due to book keeping errors or to chimeric inserts. Their present approximate location relative to the oric is shown in FIG. 3: Y63 at 380 kb, Y63A at 2300 kb, Y180 at 2160 kb, Y251 at 100 kb, and Y253 at 2700 kb. A total of 48 BACs, covering regions of the chromosome, not represented by cosmids were then shotgun sequenced (Cole et al., 1997), and these are squared in FIG. 3. No chimeric BACs were found, which is consistent with the observations of other research groups for other BAC libraries (Cai et al., 1995; Zimmer et al;, 1997). The absence of chimeric BACs was of particular importance for the correct assembly of the M. tuberculosis H37Rv sequence. The exact position of the BAC termini sequences on the chromosome will be available via the world wide web

TABLE 2 Identities of genetic markers previously shown on the integrated and genetic map of H37Rv (Phlipp et al., 1996b) which showed perfect sequence homology with BAC end sequences. BAC end Description of GenBank Locus sequence genetic marker Organism Accession n^(o) apa Rv163SP6 Secreted M. tuberculosis X80268 alanine-proline-rich antigen dnaJ, Rv164T7 DnaJ hsp M. leprae M95576 dnaK fop-A Rv136T7 Fibronectin binding M. tuberculosis M27016 protein polA Rv401T7 DNA polymerase I M. tuberculosis L11920 ponA Rv273T7 Penicillin binding M. leprae S82044 protein pstC Rv103T7 Putative M. tuberculosis Z48057 phosphate transport receptor recA Rv415SP6 Homologous M. tuberculosis X58485 recombination wag9 Rv35SP6 35-kDa antigen M. tuberculosis M69187

Example 5

Repetitive Endsequences.

Repetitive sequences can seriously confound mapping and sequence assembly. In the case of the BAC endsequences, no particular problems with repetitive sequences were observed. Although nine clones with one end in an IS1081 (Collins et al., 1991) sequence were identified, it was possible to correctly locate their position on the map using the sequence of the second terminus. Moreover, these BACs were used to determine the exact locations of IS1081 sequences on the map. Five copies of this insertion sequence, which harbors a HindIII cleavage site, were mapped on the previous physical and genetic map. In contrast, BAC endsequence data revealed an additional copy of IS1081 on the M. tuberculosis H37Rv chromosome. The additional copy was identified by six clones (Rv27, Rv118, Rv142, Rv160, Rv190, Rv371) which harbored an identical fragment linking Y50 to 1364 (FIG. 3, at ˜1380 kb). This copy of IS1081 was not found by previous hybridization experiments probably because it is located near another copy of IS1081, localized on the same DraI fragment Z7 and AsnI fragment U (FIG. 3, at ˜1140 kb). Furthermore, the position of a copy of IS1081 previously shown in DraI fragment Y1 (FIG. 3, at ˜1840 kb) had to be changed to the region of Y349 (FIG. 3, at ˜3340 kb) according to the endsequences of BAC Rv223. The positions of the four other IS1081 copies were confirmed by the sequence data and therefore remained unchanged. In total 6 copies of IS1081 were identified in the H37Rv genome in agreement with the findings of others (Collins et al., 1991).

In addition, a sequence of 1165 bp in length containing a HindIII site was found in two copies in the genome of H37Rv in different regions. The endsequences of BAC clones Rv48 and Rv374, covering cosmid Y164, as well as Rv419 and Rv45, that cover cosmid Y92, had perfect identity with the corresponding parts of this 1165 bp sequence (FIG. 3, at ˜3480 kb and 900 kb). Analysis of the sequence did not reveal any homology with insertion sequences or other repetitive elements. However, as each of the two locations showed appropriate BAC coverage, chimerism of the sequenced cosmids Y164 and Y92 can be ruled out as the probable cause.

Example 6

Using BAC Clones in Comparative Genomics.

The minimal overlapping set of BAC clones represents a powerful tool for comparative genomics. For example, with each BAC clone containing on average an insert of 70 kb, it should be possible to cover a 1 Mb section of the chromosome with 15 BAC clones. Restriction digests of overlapping clones can then be blotted to membranes, and probed with radiolabelled total genomic DNA from, for example, M. bovis BCG Pasteur. Restriction fragments that fail to hybridize with the M. bovis BCG Pasteur DNA must be absent from its genome, hence identifying polymorphic regions between M. bovis BCG Pasteur and M. tuberclosis H37Rv. The results of such an analysis with clone Rv58 (FIG. 3, at 1680 kb) are shown here. This clone covers a previously described polymorphic genomic region between M. tuberclosis and M. bovis BCG strains (Philipp et al., 1996a). EcoRI and PvuII digests from clone Rv58, fixed on nitrocellulose membranes, were hybridized with ³²P-labelled total genomic DNA from M. tuberclosis H37Rv, M. bovis (ATCC 19120), and M. bovis BCG Pasteur. FIG. 4 presents the results of this analysis, where it is clear that several restriction fragments from clone Rv58 failed to hybridize with genomic DNA from either M. bovis or M. bovis BCG Pasteur. On the basis of the various missing restriction fragments, a restriction map of the polymorphic region was established and compared to the H37Rv sequence data. The localization of the polymorphism could therefore be estimated, and appropriate oligonucleotide primers (Table 1) were selected for the amplification and sequencing of the corresponding region in M. bovis. The alignment of M. bovis and M. tuberculosis H37Rv sequences showed that 12,732 bp were absent from the chromosomal region of the M. bovis type strain and M. bovis BCG Pasteur strain. The G+C content of the polymorphic region is 62.3 mol %, which is the same as the average genome G+C content of the M. tuberclosis genome, hence indicating that this region is not a prophage or other such insertion. Subsequent PCR studies revealed that this segment was also absent from the Danish, Russian, and Glaxo substrains of M. bovis BCG, suggesting that this polymorphism can be used to distinguish M. bovis from M. tuberclosis. Analysis of this sequence showed that 11 putative open reading frames (ORFS) are present in M. tuberclosis, corresponding to ORFs MTCY277.28 to MTCY277.38/accession number Z79701-EMBL Nucleotide Sequence Data Library (FIG. 5). FASTA searches against the protein and nucleic acid databases revealed that the genes of this region may be involved in polysaccharide biosynthesis. Among these putative genes, the highest score was seen with ORF 6 (MCY277.33), whose putative product shows a 51.9% identity with GDP-D-Mannose dehydratase from Pseudomonas aeruginosa (accession number U18320-EMBL Nucleotide Sequence Data Library) in a 320 amino acid overlap. The novel M. bovis sequence of the polymorphic region was deposited under accession number AJ003103 in the EMBL Nucleotide Sequence Data Library.

As it appears from the teachings of the specification, the invention is not limited in scope to one or several of the above detailed embodiments; the present invention also embraces all the alternatives that can be performed by one skilled in the same technical field, without deviating from the subject or from the scope of the instant invention.

TABLE 3 End sequences of the polynucleotide inserts cloned in the named recombinant BAC vectors contained in the I-1945 M. tuberculosis H37Rv genomic DNA library. RvXXXSP6 corresponds to the SP6 endsequence of the clone RvXXX; RvXXXT7 corresponds to the T7 endsequence of the clone RvXXX. RvXXXIS 1081 corresponds to a region located close to a copy of the IS1081 repetitive sequence (Insertion element) The character <<->> denotes an uncertain base residue. Clone Rv101 ::::::::::::::Rv101SP6.seq:::::::::::::: AATACTCAAGCTTGCCCAGCCGTCGATGACAAGAAATATGTCCGCAAAAGACTCAGCGGCCGACTTTTGCTCGCAGCTGGCGGTACCGCGCCACCGATTCTATGCCG (SEQ ID NO. 6) TGGTCGCGGAAAAATGCCTCCCGAAATCGCACGGCCGACTCCAGTTCGGCGAGCATCCGCGATGCCAGCTGCGGCTGCGCCCTGCCGGCCACGGCACCCACATGCG GCAGTTCGTCCACCTGGGCCAGCGCCCCGCCGCCGAATTCCAAACAATAGAACTGCACCCGGCCCGCATCTGTGGGTAACAGCCAACGCCATGATCAGCGTCCGCAG CGCGGTTGACTTGCCCGTTTGCGGTGCACCTACGAACGCGACATTGCCTGCGGCCCCGGACAAGTCGATCGTGCGCGGCACCGTGACTGCTCTAACGGGCGATTG AAATTCCGAT ::::::::::::::Rv101T7.seq:::::::::::::: CCACCCGTGTAATTTGGGATGGGCAAAAAGGCGAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTGGGCGGTTAGGGCTTCTCGCCGGGAAGGCCCGAAC (SEQ ID NO. 7) GTACGGCGTTTCAACACCTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGCTGGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGG TAGTCGCCGCCCGGGCGGCTACACTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCCGACGCAACGGTTCCTACACCGCGATATGTTCGCCTCGCTGC CCCGGTGGACCGGT Clone Rv102 ::::::::::::::Rv102SP6.seq:::::::::::::: AATACTCAAGCTTTCCGCCGATACCCGCCATGTCGCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAGTGCGGATGATCGGGCCGCC (SEQ ID NO. 8) TACGTCGTGGTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAAGG CCTATGTCACCGGTCCGGCAGCACTCAATGCCGACCAGGCCGAGGGCGGAGACAAAAGTATCGCTAAGGTCACCGCGATCACCAACATGGTGATCGCAGCAATGTT GCTAGTGATCTATCGCTCCGTAATTACCGCGGTTCT ::::::::::::::Rv102T7.seq:::::::::::::: GTGCCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGG (SEQ ID NO. 9) ACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCGTTGACCGGGCGGATCGCGGTGATCGTCGA TGACGGCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCGATCGGCCCAGACGACATC GTGGCGAGATTCGCCGGGTACGCCGATGAGGTGGT Clone Rv103 ::::::::::::::Rv103SP6.seq:::::::::::::: AATACTCAAGCTTTCGGCGGAAACGGACACATTGCGAATATTGATGACAAAATAAAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAA (SEQ ID NO. 10) ATTCCAATCAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCCGTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATA TGGCGAAAAACGGTCGCCGTTGCACGACATTAAATGTCACGGTATTGTAGATTAAAAAGATACCCAC ::::::::::::::Rv103T7.seq:::::::::::::: TGCTCCCGAAACCTGGGGTGTGCCTGCTCTGTATGCACGGCATACGGACATCCTTCCCCTGAGACCCGCGGTCGAACCAGCCACGTGTCCATCATAGNGGGTCAA (SEQ ID NO. 11) CCCCGGCCAAGGGCGACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGATCAAAACAGCTGGTCGGCCGTTAGGAACTGAATT GAAACTCAACCGATTTGGTGCCGCCGTAGGTGTCCTGGCTGCGGGTGCGCTGGTGTTGTCCGCCTGTGGTAACGACGACAATGTGACCGGGGGAGGTGCAACCACT GGCCAGGCGTCGGCAAAGGTCGATTGCGGGGGGAAGAAGACACTCAAAGCCAGTGGGT Clone Rv104 ::::::::::::::Rv104SP6.seq:::::::::::::: ATACTCAAGCTTTGCCGACGAGCGGGCGATGTTGATGACGGGAAACCCCAGCGCACAACCGACGATTTTGGCGTAGCCGGCGGACGTCTGCTCGATTCCGATCAGG (SEQ ID NO. 12) TCGGCGCTCGCATCGAGCATGGCGCCGGCGACGGCTAGCAGCGATCCGCCGTCGTCGAGGAGCACGACACGAGCCGTACGCCCGGCCGTAAGCCGCGCCCAGGATT CGGCGAAAAACCGTTCTACGTGGCGGGTGTACTGGGTGTCGAATGATTCGTGGGGTGCGTAGGCGTCGCTGCAATCGTCGACATAGATGCCGTCGGGCCGCATCGC GTCGACAACTCCGGGTGAGTGGAATAGCACTTGCCGATCACCGCGACGTTGCGCGGATGAGGCCGAACCCGAATA ::::::::::::::Rv104T7.seq:::::::::::::: TCCTATGTCCCTGCCGAGCANGTGATCGAACGCGGTGACAGATTTGTCTATCCTGGACCTGACGGTGAGGTCGAAGTTTTCCAGGAATTCGGCAAAATCGGTAAGA (SEQ ID NO. 13) GCCTGAAGAATTCGGTATCGCCGGACGAAATCTGCGACGCATACGGGGGCATATACGCTTCGGGTTTACGAGATGTCGATGGGGCCGCTGGAGGCTTCACGTCCAT GGGCCACAAAGGATGTTGTCGGCGCGTACCGTTTTCTGCAGCGGGTGTGGCGCTTGGTCG Clone Rv105 ::::::::::::::Rv105SP6.seq:::::::::::::: ATACTCAAGCTTGATTCCGCCGAAACCGACCGTGAGCACCCCGCCAGCCACCACGCTCGGGTCGGGCGCCGGGCCCGGGCCCGCCAGGCTGCTCCGCTCGGTGATGG (SEQ ID NO. 14) CACGCCACCGCGACACCACCCGGCTGCGCTACGTCTAACCATTCCAGGCGGAGCTACATCAGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCCAGGTCGAAGTCTA TACCGATATGCGCATCCGCAGCCGCCACCCTGGAGAACAGAACGATGCCCTACTAATGCTTGTCTGGCGGGGCC ::::::::::::::Rv105T7.seq:::::::::::::: GGTACGCTTCGGTCGCAGTCTGCGAGTGATGCATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGGAATCCAACCGGTA (SEQ ID NO. 15) GAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGCAGGCTTCGTCGGGGTGGTCGCGA CGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCACGTAGACGGTTCCTTTCCTAAGCAACACCGAAGTTTCAGGACCCGAATGCTCCGGGA AACATGTCACGGTAGGTCGGTATTCCGGCTACCGGCTGA Clone Rv106 ::::::::::::::Rv106SP6.seq:::::::::::::: GGCGTCAACGGTGTCGGAACCCGCGTCAAGCAATTGGTAGGCCTGCAGTCTGTGAATCAGGCCGACGCTGTGGCCGCCGCGGC (SEQ ID NO. 16) ::::::::::::::Rv106T7.seq:::::::::::::: GGCTNGCGTACCCGGTACCGGCCGCGGGCCTACCACGTGCCGGAACTGGAAGCGCAGTAAGCCCTCAACGCGCCACCGCTTTGGCCCGCGCGCCCGGCGTAGGCGC (SEQ ID NO. 17) ATCGGCGGTGGCCGTGGGGCGGCGCACTGCGACCTCACCAGCGGCTTTCGAGCTTTGTTCGATCAACCGGCCAGCATGGTCGANGATGCATTCGAGACCATATTCG AAATTGGTTTCATCGGGGGCCCCGATCCGATGCCCCCTCCCAGTTGCGTGAGCAANCAGCGGAGTCNTCGCGGGATCGATGGCCACGGGGTGTTCAATGGCGGATG GTCCGCTGCCCGCCGACTGGCTCTTGCGGGAGAACCGATCTAGCACCACCGATCCGCGCACGTNG Clone Rv107 ::::::::::::::Rv107T704.seq:::::::::::::: GTAATNTCGCGCACANCCANGACTTCTGGGGGGATCNGCTGACAGTGGNGGATCCCAAATTGCGGATGATCGGGCCGCCNACGTCGTTGTGTACCTCNTCNGTC (SEQ IN NO. 18) ACAACNAANCCGAANCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCNCGGGGTGAAGGCCTATGTCACCGGTCCGGCAACACT CAATGCCGACCAGGCCGANGCCGGACACNANAGTATCNCTAACGTCACCGCGATCACGAGCATGGTGATCGNNCAATGTTNCTANTGATCTATCGCTCCGTAATTA CCGCGGTTCTCGTCTTGATCATGGTCGCANCGAACTCCGGCGCAATCCGCGGATTCATCGNCTTGCTCGCCGATCACATATTTTCAGCCTTTCACATTGCAACNAA CCTGCTCGTCTCATGGNGATGCGGCGACACGGACTACCGATATCATGCTCGCCGTTACACAATCNCGCCACGCCGCGAAGACNGGAAACGCTTCTACACAATNTTC NCGGGACGCCACTNAACTTGGTTCNGGTTTGACATTGCCGCGCATGTNGCCCAGCTTTGCCGGCTCCCCTTA Clone Rv108 ::::::::::::::Rv108T704.seq:::::::::::::: TGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGGGCGGATTGGCCCTGCNGCTGCAGCANACCATCGACGCC (SEQ ID NO. 19) ATCGAATTGCCGGCAATCTCGTTCAGCCAATCCATACCCATCGACATTCCGCCGATCGACATCCCGGCCTTCNCCCTTTAACGG Clone Rv109 ::::::::::::::Rv109SP6.seq:::::::::::::: AACAGCTATGACCATGNTTACGCCAAGCTATTTAGGTAACACTATANAATACTCAAGCTTTTACGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCA (SEQ ID NO. 20) NCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCCGCGGTCNGGTGCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCC ATATCCCGCGACNAACNACNCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCGCGTTCTCCACCGACCGGGCCCGGGTGTGGGGTGTTTCGGC GACCGGCAGCCAGGTGGTCCACACTGCCGACGGGCGCCGCGAGCCGTTCACCGACCAAGCCGCCGAACAAGTCCGCCCGATCGCATACTCCAACCGGTTGCGGTAC TGCAGGTCAGCTGGCGTACCTCCTCNTCNCGCTGGCGAAGTCTTFGCTCANCACGTCGCAGAACGGCAAGGAACACGTTCA ::::::::::::::Rv109T7.seq:::::::::::::: GACCGNNCCATGTTTCCACAATGTGGTGCCAGTNCGGNGGCTACGTGCCATCNANACACTGGCGCAGGCTATCGCACCCGTTATCNGCTACGAACAAATNCGGTA (SEQ ID NO. 21) TGCGTTCTTTANCATGAGTCGGCGACCGNCGATCATGGTCGACACCCACGACNGAAATACGCAGATCGCCNTCNAGCNTGTGTGCCGCGGATTATCANGACTGACC TCCTGGCTGACCGGNNTGTNTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGNTCGTGGTCGGCTCGGATAGCGAAGTCAGCTAATTCTCGTGGCAGCTCGAAAGGG TCCTGCCGGTGCCGGTCTTTGCGCAAACCATGCNCATGTTACGGTCCCTCGGGTGCGGCCTGGCGGCGGC Clone Rv10 ::::::::::::::Rv10SP6D2.seq:::::::::::::: GGGATGGGCGGGCCCGCTAAACTCTTCGTGTTCCACTAACTCCGGGAGGGNCAATCTCGGGCCGTTATGGCTCACGTCGCGTCGCCCTCCGACCGCGAACATTCGG (SEQ ID NO. 22) AGTTGGCAGCAACCTGGTAGCACCCTGGCCGG ::::::::::::::Rv10T704.seq:::::::::::::: NCCGTCGTTGACAAGTAAATATGTCCGCAAAAGTCTCAGCGGCCGACTTTGCTCGCAGGTGGCGGTACCGCGCCACCGAGTCGATGCCGTGGTCGCGGAAGAATGC (SEQ ID NO. 23) CTCCCGAAATCGCACGGCCTTCCCNNTTTAAACGGA Clone Rv110 ::::::::::::::Rv110SP6.seq:::::::::::::: TTTAGGTGACACTATAGAATACTCAAGCTTTTGGTCTAGCCGGCCGAGCACGATACGGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCG (SEQ ID NO. 24) GTGGTTTTGCTGATGAGTGCTGAACCGTANTCGAAGTGGGCGGCGTCAGACTCCACCCANCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCNATCC GGACAAGTTGGGGTGCGTTTGGGGCAATGACAGGTGGCNGCGGTGCGTTCGGGTCCGCCGGCGGAAGTGCTGCGTTGGGATCNCCCGCTGGGCATTCGGCNTTTT GCGGCGGCCGGTGGTNGGGGGGCAACAGGTNTCCCNGTGCGGGTGGCGCTCAACGGTCNACGGCGCAAGCCGCCGTTGTTGGTACCNGGGGCGCTGGCTCCGGATC GCGTTGGCGGTCNCCGG ::::::::::::::Rv110T7.seq:::::::::::::: CTACACCATCGAATACGACGGCGTCGCCNACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTAC (SEQ ID NO. 25) TTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGANAACCTGCCGCTGC TAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAANGTGATTGTTAACCTGGGCTACNGCGACCCGGCCTATGG TTATTCNACCTCNCCGCCCAATGTTGCGACTCCGTTCGGGTTGTTCCCANAAGTCNNCCCGGTCGTCATCGCCGAANCTCTCNTCCCGGGACCCACAGGGAATCNG CNATTTCNCCTACAAATCANCCACCTCCA Clone Rv111 ::::::::::::::Rv111T7.seq:::::::::::::: GCATGATCGGCCACCTTTCGGGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGT (SEQ ID NO. 26) GACGACTCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCACCAACGGCGCGAGCTCAACGACGTCAATCNCGTTGTCGCTTTCTACGGTCACCGACCCTGGT GACCGTAGTTCNCCCG Clone Rv112 ::::::::::::::Rv112SP6.seq:::::::::::::: GACACTATAGAATACTCAAGCTTGCCAACCGCCAGCCTGCATCCGGCGGCGANCACTGCTCCGCCGACCAGTACGAACCAACCTGCGGTGCCCAGGCCATTGACGA (SEQ ID NO. 27) TGTGCTGGTCGGCGCCCGCGAGTCCGCGCACCATCAACGCCGCGGGCACCACCANGGCGGCCCCACCCTGCACGGCGACGATCATTCCGGCGCCGCTCACGGCGGG CGGGGCTCGAACANGCACAGCATCAACGTNGTCACCCGGCCGTGACCGGCCCGCATCGTCACACCACCCAAGCCCATTGCCGTCCTCCTCAACNGGGCGACCCGGC CCGCATCGTCACACGGNCTAAGGCCATTGCCGTCCTCCT ::::::::::::::Rv112T7.seq:::::::::::::: TCGGCGCCATCGGCACCTTCGAGGACCTGTATTTCGACGCCGTGGCCNACCTGAGGTTGGCGGTGGCNAAGTGTGCACCCGGTTGATTCGCTCGGCCTTGCCGGA (SEQ ID NO. 28) TGCCACCCNGCGCCTGGTGGTCGATCCGCNAANAGACAANTTGTGGTGGANGCTTCTGCTGCCTGCGACACCCACNCGTGGTGGCACCGGGCAGCTTTAGCTGGC ATGTCCGACCGCGCTGGCCGACNACTCCAGACNTTCCACNAANGGTCGCONNCCCAATGTNCCGNANTGTCTCCGGNTCCCTTTACCNCCCAATGGGCNGNTTCC ACNGGTTACGGGCCCCNTNCCGGCGGGTCTNCCTCCCAANCTACCAAATACGCCCGACNTTCCGGA Clone Rv113 ::::::::::::::Rv113SP6.seq:::::::::::::: ATACTCAAGCTTTTATGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCG (SEQ ID NO. 29) GGTGCAGGTCTCGGGCAGCTCGGCCGCGAACAGCCCGGCTTGAACCCTGAAAACCNGCTTTCCATATCCCGCGACGAAAGAACGCCAGTTCCGCTACTTAACCCC TCCGCGAACCGTCCATGGACAACAGCGCGTTCTCCACCAACCGGGCCCGGGTGT ::::::::::::::Rv113T7.seq:::::::::::::: TCGGCTCAGGCCGCGCTGCTGGTAGAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCG (SEQ ID NO. 30) CACCCGTTATCGGCTACGAAGCAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCA AGCATGTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGGATAGCGA GGTCAGCGAATTCTCGTGGCAGCTCGAAAGGGTCCTGCCGGTGCCGGTCTTTGCGCAAACAATAGCGCAGGTTACGGTCGCGCGGGGTGCGGCCTGGCGGCGGCC Clone Rv114 ::::::::::::::Rv114SP6.seq:::::::::::::: CAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTCGCGTCTACGCCGGCCCGGAGCATCCGCACAGCGCTCAGCAGCCGGTTCCGTACGANCTCAAGCAGGTG (SEQ ID NO. 31) GCGCAATGACCGAAACCACCCCAGCCCCGCAAACCCCGGCGGCCCCGGCCGGGCCCGCACAATCGTTCGTGTTGGAGCGGCCCATCCANACCGTTGGGCGCCGTAA GGANGCCGTGGTACGAATGCGGCTGGTGCCCGGCACCGGCAAGTTCGACCTCAACGGCCGCAGCTTGGANGACTACTTCCCAAACAAGGTGCACCAGCAGTTGATC AAGGCACCCCTGGTCACCGTGGATCGGGTGGAAAGTTTCGACATCTTTGCCCACCTGGGCGGCGGCGGCCGTCCGGTCAGGCCGGGCCTGCCCTGGGTATCGCCCG GGCATTGATTCTGGTATCCCCNGAAGAACCG ::::::::::::::Rv114T7.seq:::::::::::::: CGGTTGGCCACCGCTTCTGCGGTGCCGCCGCCGTCGACAATGACCGTGTCGTCCTTGCTGACCACCACGCGTCGGGCCCGAGCCCAGCACCTCCAAGCCCACCTCGC (SEQ ID NO. 32) GCAGCACCATGCCGGCGTCGGGGTTGACCACCTGGCCACCCGTCACCACCGCCAGGTCCTCAAGGAAACGCTTACGGCGGTCACCGAAGTACGGCCCCTTGACCG CGACCGCTTTCAACGTCTTGCGAATCGCGTTGACGACCAGCGTCGCCAACG TTCGCCCTCCACGTCTTCAGCCACGATCAGTAGTGGCTTACCGTTCCTGCAAC CTTTTCCAGCAATGGCAACAGATCGGGAAGCGANCTGATCTTGTCTTGGTGCN Clone Rv115 ::::::::::::::Rv115SP6.seq:::::::::::::: CCAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTTTGGCTGGGTCGCCTTCGAATTCNGCGTGCACCGCTATGGGTTGCANCAGCGGCTGGCGCCGCACACC (SEQ ID NO. 33) CCACTGGCCCGGGTGTTTTCGCCCCGAACCCGATCATGGTGAGCGAAAAGGANATTCNCCTGTTCGATGCTGGGATTCGCCACGCCAAGGCATCTANCGATTACT CTCCNCGGGGTGGGAAAAGTGCCCAATCCCCTCCCTCCAACTTTCCNAACAATCATTCCGGTTCCNCCNTCCGGTTGGNGGTAACCNNCCAATAAAACCCCTGCC CG ::::::::::::::Rv115T7.seq:::::::::::::: GCCCGCNCATGGCCAATCCCCGAAGACATCATTGGCCAGTGGCCGGGCGCTAACAGGTTCCAGCCCCCCACCANTGCCGCTCGAACATGCGGTGCAACCCATTCGC (SEQ ID NO. 34) AGGCCGGCAGGGAAAGCACCGCGGAAGCCGCAAAGGGCTGCAGTTCCGCGCCCAATAATGTCGTCCGCAACCAGATGCGCTCNAAAACCNCNCCGGCAGTCAGCGC ACCCGACGCGANGTCGAAAGACGTCNTCAGCGCGCCCACATGGGGTGCCAATCGGCACGGCAGGTATGCCGCGCGCAACCCGAGCGCGTGGTGCATGCCCACGGTC CGCANGANGCGCANCACCCGCCAATGCCGAANCCCACGAAACATCGGGCGCATCCACCTTCAACC Clone Rv116 ::::::::::::::Rv116SP6.seq:::::::::::::: ATACTCAAGCTTGCCCAGCCGTCGATGACAAGAAATATGTCCGCAAAAGACTCAGCGGCCGACTTTGCTCGCAGCTGGCGGTACCGCGCCACCGAGTCGATGCCGT (SEQ ID NO. 35) GGTCGCGGAAGAATGCCTCCCGAATTCGCACGGCCAATTCCATTCCGGGAAGCATCCGCAATGCCAGCTGCGGTTGCCCCCTGCCGGCCACGGCACCCACTTGCGG CATTGCGTCCACCTGGGCCAGCGCCCCGCCGCCAAATTCCAAACAATAAAAATTGCACCCGGC ::::::::::::::Rv116T7.seq:::::::::::::: CCACCCGTGTATTTTGGGATGGGCAAAAAGGCGAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAAC (SEQ ID NO. 36) GTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGG TAGTCGCCGCCCGGGCGGCTACAGTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCGACGCAACGGTTCCTACACGGCGATATGTTCGCCTCCCTGCC CCGT Clone Rv117 ::::::::::::::Rv117SP602.seq:::::::::::::: CTGCCCATGTTTGGGGACGCCCGACCAGCCGATGCTGGAGGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCGTTGGTGACC (SEQ ID NO. 37) GGCAATACCTACCGCAGCCNGACCCCTNTCNCAANAGGATNTTGTTCGCCGGACCCCNCTC ::::::::::::::Rv117T704.seq:::::::::::::: CCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGA (SEQ ID NO. 38) CGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATC GTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGCGACCGCCTTT Clone Rv118 ::::::::::::::Rv118SP6.seq:::::::::::::: ATACTCAAGCTTTGTCACACCAAGTGTTTCGACCAGGCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCA (SEQ ID NO. 39) GCTCGCTTGCGGCGCTGCAGCAGCCATTCGGGGAAATACCTGCCCTGGCGCAGCTGGGGGATCCCAACTTCAATGGTTGCGGCACGGGTGCTAAATTCACGGTGGC GGTAGCCGTTGCCCTAATTGGACCGCTCATCGCTGCTTTCGCGGTACCCCGCCCCGCACAGGGCTTCGGCTTCAGCCCCCATCAGGGCGGCAATAAACTTCAAGAG CACC ::::::::::::::Rv118T7.seq:::::::::::::: GAGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGCCCACCCTCATTGGCGATGGCGCCGACGAT (SEQ ID NO. 40) GGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGTCAAGTCCGGTCTACGCTTGGGCCTTTGCGGACGGTCCCGACGCTGGTCGCGGTTG CGCCCGCGAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCACCGCCGGCGGCATGCACGGCCAGTGCCGCGGCGATGTCAGCCTCGGGACATCATGCTCGCGTT CATACTCCTCGACCAGTCGGCGGAACAGCTCGATTCCCGGACCGCCCAGCGCATTGGTGATGGAATCGGCGAACTTGGCCACCCGCTGGGTGTTGACATCCTCGAC GGTGGGCAATTGGCCTCGGTAAGCTTTGCCGCGTAGCTTTTCATC Clone Rv119 ::::::::::::::Rv119SP6.seq:::::::::::::: ATACTCAAGCTTCACTGACAAGGGACGAATTCGTCGGCCGCCTGTTCGACTGGGTGGTGGCCGAGCTGGTCGCCACCACTCAGGCCGCGGTCACGGCGGTACCGGC (SEQ ID NO. 41) GCGGGAGCAAACTCGCGCGGGCATGGCCAACTTCTTGCGGACCATCACCGCAGACGCCCGCTTCGGACCCCTGCTGTCCACCACACAGTTGGCCAACGCATTAATC ACCCGCAAGCTTGCGGAATCCACCGCCCTGTTCGC ::::::::::::::Rv119T7.seq:::::::::::::: TCCATCACCCGATGTGGCNGGAGCACTGCCATGTCGATCTCAACTACCACCTCCGGCCGTGGCGGTTGCGCGCCCCGGGGGGTCCGCGCGAACTCGACGAGGCGGT (SEQ ID NO. 42) CGGAGAAATCGCCANCACCCCGCTGAACCGCGACCACCCGCTGTGGGAGATGTACTTCGTTGAGGGGCTTGCCAACCACCGGATCGCGGTGGTTGCCAAAATTCAC CATGCGTTGGCTGACGGTGTTGCCTCGGAAACATGATGGCACGGGGGATGGATCTGCCGCCGGGACCGGAGGTCGGCCGCTATGTGCCTGACCCCGCTCCTACCA AGCGGCA Clone Rv11 ::::::::::::::Rv11SP6.seq:::::::::::::: AGCTTTGCAGTTGCTGAGTAATGTCGGCCAACGTCACCACAACCGCGATGAATTCAATCATGCCGCCCAGGGCGGCCAACCAATGGTGGCCGCGAGCGGCAGCTC (SEQ ID NO. 43) GATCGCAGCGCGGAGGTTGCCGGCCGCCAGTTGATTCACGAACAGGGTGAGGTCATAGGCGGGCAGGATAGTGACGAAGGCAAGACCTCCATCTGCCGTCGGAAGA AGTATCGAG ::::::::::::::Rv11T7.seq:::::::::::::: AGCTTCAGAACAGGCCTGTTGTGGGCGCACCCGGCTCGCCGAGTTCTGCACGCACCGCCTCAAGTGCGGCCCGCACCGCCGGCATCTCCCGGTCACGCAGGGCCGC (SEQ ID NO. 44) GGCCCGCGCCGCAGCGACGGCGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGTTCTCGGCGTCGTCGCGTTCACTAATCGCGGTG CTCAGCAGCGTCTCGACAGCCACCACCCGAGTGGCGACCAGCTGCTCCACCACGGACCGAGCGATGCCCGTC Clone Rv120 ::::::::::::::Rv120SP6.seq:::::::::::::: ATACTCAAGCTTCAGTTCCTCCACGACGCGTTCCCAAATGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGG (SEQ ID NO. 45) GCGGATTGGCCCTGCCGCTGCACCAAACCATCAACGCCTTCAAATTGCCGGCAATCTCGTTCAGCCAATCCAT ::::::::::::::Rv120T7.seq:::::::::::::: GCTCTACGCCGCCTACGGGTCGAACATGCATCCCGAGCAGATGCTCGAGCGCGCACCCCACTCGCCGATGGCCCGGAACCGGCTGGTTACCGGGTGGCGGCTGACG (SEQ ID NO. 46) TTCGGCGGCGAGGACATCNGCTGGGAAGGGGCGCTTGCCACCGTCGTCNAAGACCCAAATTCGAAGGTGTTCGTCGTGCTCTACGACATGACCCCGGCGGACGAGA AGAACTTGACCGGTGGGAAGGCTCCGAGTTCGGTATCCACCAGAAGATCCGATGCCGCGTGGAGCGCATTTCCTCGGACACCACAACGGGATCCCGTCCTCG Clone Rv121 ::::::::::::::Rv121SP6.seq:::::::::::::: ATACTCAAGCTTGCCAAAGAGACCTCGTCCACCAAGCAGGACGCGACCGTCGAGGTGGCGATCCGGCTTGGCGTCGACCCGCGTAAGGCAAACCAGATGGTTCGCG (SEQ ID NO. 47) GCACGGTCAACCTGCCCACACCGGCACTGGTTAAGAACTGCCCGCGTCGCGGTTTTCGCGGTTGGTGAAAAGGCCAATGCCTGCGTTTGCCGTGGGGGCGGATGTT GTCGGGAGTGACAATCTGATCAAAAGGATTCAGGGCGGTTGGCTGGAATTCAATGCCGCAATCGCGACACCGG ::::::::::::::Rv121T7.seq:::::::::::::: CCACGGCGTGGATCAAGGTACCGGCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGATGTCGGCGTTAGCGCCGGATTCCACCACATCCCCTTGCGAAAG (SEQ ID NO. 48) TCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCTTGGCGTTG ACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTGGTAATCCGGCCATGCGCGTTGCGTCCACCGC GACGTGCAGCGGGGCGCACCAGCGACTTCTCCGGGGTTGACCGGGTNATCT Clone Rv122 ::::::::::::::Rv122SP602.seq:::::::::::::: GCAGCATGACGGCGGTAGCGAACACCGCCGGATGCAGCGCAAGTAGCGTCGATGTGCTCACGGAATCGCCCCGGCACCGCGATCTCGANGATCACCAGTGCCACCC (SEQ ID NO. 49) CCTGCAGCGCNACACCGACGATTCCGTACACCGCCACGCCGATCAGGCCCTGGGCCATCTGATTGGAGCTGGCGTANATGGCGGCGATGGTGACGATGGCCAGCGC CACATACATTGTGGCGGCCAGAACCACGGCGTTGGGGCGGCGGTCGATGAACACTAGGCGACGCAGATCGCCCGGGGTCAACAGGTTGACCATCAGAAAGCCTGCG ACTAGCACGGCGGCGCCACTAGGAGGTACAAGAANGTGGCCACCACCCCATGCAGGATCGGGGTAAGGCTGATGGTCCCGAAATCGACTCCGGCCTAATACATGAC TCTCTCCTTTGCGTCATCGCCTTACTTGTGCGCGGAA Clone Rv ::::::::::::::Rv123SP602.seq:::::::::::::: GGGACACACCTCGATGCTGCCGCNATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACGCATCCCGTT (SEQ ID NO. 50) GACCGGCCGGANCNCTCTCTA ::::::::::::::Rv123T704.seq:::::::::::::: TGGGCGCCTCTTTCGGCCTTCCCNNTTTAAACGNAGCANGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGG (SEQ ID NO. 51) GATCCGACTACAATCTGCTGCTGATTTCCCGGTTGAAAGAGGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGAC GGCTGCCGGCATGGTGTTCGCCGTTACCATGTCGTTGTTTGTGTTCAGGATTTGCGAATTATTGGTCAGATCGGTACCACCATCGCCTTCCC Clone Rv124 ::::::::::::::Rv124SP602.seq:::::::::::::: CCGATCGGCGCCGCANCTGGTTGGTGTTNCGGATGAATCGCAGCGAAAATGTAGCTGCGGTGGCGTGTCGTGACTCGTNGGCGTCGACGCTCGTGGCAGCCACCG (SEQ ID NO. 52) ANCGGTTGGTCCAGGATCTGGATGGGCAAAGTTGTGCGGCCCGGCCGGTGACGGCCGATGAGCTGACCGAGGTCGACAGCGCCGTGTTGGCTGACTTGGAACCGAC ATGGAGTCGCCCCGGTTGGCGTCACCTCAAGCATTTCAATGGTTATGCGACCAGTTTTTGGGTTACGCCGTCAGACATCACGTCGGAGCTTGGATGAGCTGTGTC TGCCAGATAGCCCCGAATCGGGACGACCGTGGTCACGGTGCGTCTGACCACTCGGGTCGGGTCGCCCGCGCTATCGGCATGGGTGCGTNATCACAGCGACACGCGC CTGCCCAAGGANGTNCGGNCGGACC ::::::::::::::Rv124T7D4.seq:::::::::::::: CGGGTTGCGGATCCACGCGTGCGGGTTGTCAGCAGCTACGGCACTGAACCGCGCCCACAGCTCGCCGATCCGCTTTCGGTGGTTCTCGATCGACTCGCCGTAGGCG (SEQ ID NO. 53) ATGCGCAGCGCCTGCTCGAATATCGGGTACACGTAGGCCGGCTTCCCNCTTTA Clone Rv126 ::::::::::::::Rv126SP6.seq:::::::::::::: CTTGATTTTGATCATCATGACGATCATCACCCTAATTTTGCTACCCGCACTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCGGTCGGGCTTTCCGTA (SEQ ID NO. 54) TTGGTCTGGCAGGACATTCTGGGTATCGATTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGCTGCTGATTT CCCGGTTGAAAAAGGAGATTGGGGCGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGCAGTGGTGACGGCTGCCGCATGGTGT ::::::::::::::Rv126T7.seq:::::::::::::: GGGGATCCCTAGATCGACCTGCAGGCATGCAAGCTTGGCGTGTCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGCGGGACCCACCTCGATGCTGCCGC (SEQ ID NO. 55) CATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATC GTCGATGACGGCATCGCCACCGGAGCNACTGTCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCAGACG ACATCGTGGCGAGATTCGNGGGGTACGCCGATGAGGTGGTGTGTTTGGCGACGCCGGCGTNGTTCTTCGCCGNCGGGCANGGTTACCGCAACTTCACCCAGACCTC CGACGACGAGGTGGTGGCGTCTCTCCTGGATCGTGCTC Clone Rvl27 ::::::::::::::Rv127SP6.seq:::::::::::::: AAGGCTGCAGGTCGAAGCGGNTGGTTACGACTCCCTGTGTGTGATGGACCAGTTCTACTATCTGCGTCTACACGGCCTTGGTGCGCTGGCCACGGCGACCGAGCG (SEQ ID NO. 56) GCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCCGACCCTGCTGGCAAAGATNATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCT CGGCATTGGAGCCGGCGGGTTTGAACTGGAACACCGCCAGCTCGGCTTCGAGTCCGGCACTTCCAGTGACCGGTTCAACCGGCTCGA ::::::::::::::Rv127T.seq:::::::::::::: CTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCN (SEQ ID NO. 57) GCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTACAGCCACTGCGATCGGTGCCGATCGTGG GGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGGCGACCCGGCCTATGGTTATTCGACCTCGccGNcCAATGTTGCGAC TCCGTTCGGGTTGTTCCAGAAGTCAGCCCGCTCGTCATCGCGGACGCTCTCGTCN Clone Rv128 ::::::::::::::Rv128SP6.seq:::::::::::::: CGGTCATAGCCCTCGGGTCCGGCCAGCACTCCGCAGCCTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCA (SEQ ID NO. 58) CGTAGACGGTTCCTTTCCTAAGCAACACCGAAGTTTCACGACCCGAATGCTCCGGGAAACATGTCACGGTAGGTCGGTATTCCGGCTACCGGCTGAGCATTGAGCA CGCCGGCCAGCACCGCACGAGCCAGGCAATCAGCCGCCGCCGCACCGATCGCGGTGACCAGCTGAGTCTCCGGAGACAATGCGGCCGGCACGCCGGNCTCCGGCGG CACCGCTACNGCGCCCGTGG ::::::::::::::Rv128T7.seq:::::::::::::: GTGATGGCACGCCACCGCGACACCACCCGGCTGCGCTACNTCGAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCG (SEQ ID NO. 59) AGGTCGATACCGATTTGCGCATCCGCANCCGCNCCCTGGACGACAGAACCGTGCCCTACGAGTGCTTGTCGGGCGGGGCCAAAGAACAGCTTGGCATCCTGGCGCG ATTGGCCGGCGCGGCGCTGGTCGCCAAGGACGACGCCGTTCCGGTGCTGATCGACGACGCGCTGGGGTTCACCGATCCGGAGCCACTATCAAGATGGGGGAGGTCT CTGACACCATCGGCCCCGACGGACATGTGATCGTGCCGACGTGCAGTCCCACCCCG Clone Rv129 ::::::::::::::Rv129SP6.seq:::::::::::::: GCGAAAGTCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCTT (SEQ ID NO. 60) GGCGTTGACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTNNGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTGGTAATCCGGCCATGCGCGTTGCGT CCACCGCGACCGTGCAGCGGGCGCACCAGCGACTTCTCCGGGGTTGACCGGGTGATCTCGGCGAAATCAGATACGCTGGCGCCGCGACGACCAGGCGTCGTGGGCT TGTNCTTGCGAATTGNCATGTCTAATCANGTCTTTCTCTCACGCTCTCGTCGCCGGGCTAGGCCGCATTGCCCTGCTCCTCCTCATCGCTTCGCTCTGCATCGTCC CCGGGCTAAGCCGTGCCCCGAAA ::::::::::::::Rv129T7.seq:::::::::::::: GATGGTTCGCGGCACGGTCAACCTGCCACACGGCACTGTGTAAGACTGCCCAGCGTCGCGGTATTCGCGGTTGGTGAAAGGCCGATGCTGCCGTTGCCGCGGGGGCG (SEQ ID NO. 61) GATGTTGTCGGGAGTGACGATCTGATCGAGAGGATTCAGGGCGGCTGGCTGGAATTCGATGCCGCGATCGCGAACACCGGATCAGAATGGCCAAAGTCGGTCGCAT CGCTCGGGTGCTGGGTCCGCGCGGCCTGATGCCCAACCCGAAACCGGCACCGTCACCGCCGACTCCCCATGGCGTCCCGGATATCAAGGGCCGGCAAATCAACTT CCCGGTTGATCAGCAAGGCAACCTGCCTCCNCCTCCGG Clone Rv130 ::::::::::::::Rv130SP6.seq:::::::::::::: ATACTCAAGCTTCGTCATAAGACCATGGTGCGCTTTCTTTCACCCGTCCAGAGTCGGGGGCATCGGCACCGGCTCGCATCGCATCATCCTCCCACGACGGGCCCT (SEQ ID NO. 62) CATCAGCTTGGGCCATTTCAATGTACTTGATACCCCGCGCTGCGGGTAGGCCACTGCGACAATTCAAACACGGTGTCACACGGTGAATAGTGTCGAGATGGGCTCT GATCAACCGTCGCAAACCCGGTTTCGCATCAATAGCGGAATCCCACCGGGTTGCATGGAGGCTGCTGACCTTGGAAAACAAAATTTTTTCATTACAACAAAACAAC CGCCNCGGAAACTTTGCA ::::::::::::::Rv130T7.seq:::::::::::::: CGAATTCGGCGTGCACCGCTATGGGTTGCAGCAGCGGCTGGCGCCGCACACCCCACTGGCCCGGGTGTTTTCGCCCCGAACCCGGATCATGGTGAGCGAAAAGGAG (SEQ ID NO. 63) ATTCGCCTGTTCGATGCTGGGATTCGCCACCGCGAGGCCATCGACCGATTACTCGCCACCGGGGTGCGAGAGGTGCCGCAGTCCCGCTCCGTCGACGTCTCCGACG ATCCATCCGGCTTCCGCCGTCGGGTGGCGGTAGCCGTCGATGAAATCGCTGCCGGCCGCTACCTGCAAGGTGATTCTGTCCCGTTGTGTCGAAGTGCCTTTCGCGA TCGACTTTCCGTTGACCTACCGGCTGGGGCGTCGGCACAACACCCCGGTGAGGTCGTTTTTGTTGCAGTTGGGCGGAATCCGTGCTCTGGGTTACAGCCCCGAACT CGTCACGGCGGTGCGCGCCGACGGAGTTGTTATCACCGATCCGTTGGCCGTACCGCGCCTTGGGC Clone Rv132 ::::::::::::::Rv132SP6.seq:::::::::::::: TCAGACTCCACCCAGCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGTTTGGGGCAATGACAGGTGGCGGCGGTG (SEQ ID NO. 64) CGTTCGGGTCGGCCGGCGGAGGTGCTGCGTTGGGATCGCCCGGCTGGGCATTCNGCGTGTTGGCGGCGGCCGGTGGTGGGGGGCAACAGGTGTCGCCGGTGCGGG TGGCGCTGCAGCCGTCGACGGCGGCGAAGCGGCCGTTGTGGGTACCGGGGGCGCTGGCTCCGGATCGGCGTTGGCGGTCGCGGGCACCGCAACGGTCACCAAGCTG GCGCTGGCCATCGCCGCGATAGCCAGTGCCGCCAATCGTCCCTTGCGACGTGTCAAGTNGGGGTCCACCTGATGCATGGCCAAAGAACCTACCGTGTTAACGGCGC AACNCAAGGACCGCGCCGGTCGCN ::::::::::::::Rv132T7.seq:::::::::::::: TTTCCGCGGTACCCGCTCAACTTTGTGTCNACCCTCAACGCCATTGCCGGCACCTACTACGTNCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAG (SEQ ID NO. 65) CGGGTCCGCTGAACAATTCGGTCCGTCCCACGAAAGAACCAGTTTTNCNTCTTTCNCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGG GGAACCCACTGGCGAACCTGTGTTTCAACCAACACTTAGAGTGTAATTGTAAACCTGGGCTAGGGGAAACCGGCTCTAGTTTTTCCACCNTCTCCGCCCCNTGTTT CGAATACTCCGTTCGGGTTGTCCCCAAA Clone Rv134 ::::::::::::::Rv134SP6.seq:::::::::::::: GCTTCCGGCTCGTATGTTGTGTGGAATTGTGACCCGATACCAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTAGTTAGGTGACACTATACAATA (SEQ ID NO. 66) CTCAAGCTTGCCGGCTGGTGGGCCGACCACTTCGATGGCACGACCCGTGAACTGCTGCCCGGCCAATTCTTCTTGGTCGCCCGGACCGATGGACCGGGGCTGGGAT TCCAGAAGGTGCCCGATCCCCTGGGAAAAACCGCGTGCACCTCTACTTCACGACCAACGAC ::::::::::::::Rv134T7.seq:::::::::::::: CCGATCGACTGATGCGCCGACAACCACGCCCCAACAACTGGAATGAACCGTCGTGACCATCATCAGCACGGGGTTGTAGGCGACTTGCGACATGTTCAACCCGCCG (SEQ ID NO. 67) TACTCGGACGGAATCTTCAAACCGAAACAGCCCAGCTCGGCCAGGCCTTTCACGTACTCGTCGGGGATCTGGGCACCACGCTCGAGGACGCTGCCGTCCACGGTGT CTAGGAATTCCCGCAGTTTGACCAGAAACGCCTCGGTTCGGGCCTCCTCGGCGTCCGACGGCTTGGGAAATGGGTGTATGAGCCCTACGGGAAACCGGCCCACAAA GAGTTCTTTGGCGAAGGACGGTTTATCCCAACCACTTTCGCGAGATTCCTCGGCAAGGGCCCGCGCTTGCTCCTCGGTGACCTGAGTTTGCTGTGCCATCGCCGCC TCCTCCCTGA Clone Rv135 ::::::::::::::Rv135SP6.seq:::::::::::::: TGCATCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT (SEQ ID NO. 68) ACTCAAGCTTTTACGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGG TGCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTG TCCATGGACAACAGCGCGTTCTCCACCGACCGGGCCCGGGTGTGGGGTGTTTCGGCGACCGGCAGCCAGGTGGTCCACACTGCCGACGGGCGCCGCGAGCCGTTCA CCGACCAGGCCGCCGAGCAAGTCCGCCCGATCGCATACTCC ::::::::::::::Rv135T7.seq:::::::::::::: GGGGGCGCTGCrGGTATAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTT (SEQ ID NO. 69) ATCGGCTACGAGCAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCAAGCATGTGT GCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGGATAGCGAGGTCAGCGA ATTCTCGTGGCAGCTCGAAAGGGTCCTGCCGGTGCCGGTCTTTGCGCAAACGATGGCGCAGGTTACGGTCGCGCGGGGTGCGGCCTGGCGGCGGCCAGAGCACGAG TTCACCGATGCGCAGCTAGTGGCGACAGCGTCAGCCAAC Clone Rv136 ::::::::::::::Rv136SP.seq:::::::::::::: TGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT (SEQ ID NO. 70) ACTCAAGCTTCCGTACAGGTCGCCTCCAACACGGCGGGGAAGCGACACCAGCCTACCGAGCTTGGAGTCCAGGACGCCAGCGGCGGCGTCGGTCTGCGTCGTGGTG CCGCCGGGGTGGCGTTGGCTGGCAACGATCTCCACCCAGCCGGTCGGGTTACCCACGATCTCGGCATAGACGoGGGCCGAGGCCGGTGCGATACCGTATTGCGTCA ATTGGGACGCGGTTGTGCATTCGGCTAGCTCGGTTGCCACACCCGTCAGGGGTTCGACGTTGGCGGGTTCGGCGGGCCCCAGCACCGCTGTCACCATGCCCGCCAA GCCGACCTGCGGCGCCACCAACT ::::::::::::::Rv136T7.seq:::::::::::::: CGGCATGACCACCGACAGGCCCGACTGGTCGTACCACTCGAACGCCGGGGTGTTGATGTCCCAGCCGCTGAAGTCGTCCTGCGCGCGCAGGCCGTCGAGCAGGTAC (SEQ ID NO. 71) AGGGCGGGCGAGTTGGCACCACCACTTTGGAATTGGACCTTATGTCACGGCICCATCGACGGCGACGGCACCTGCAGGTACTCCACCGGCAAGCCCGGCGGGGAAA ACGAACCCTGTCAACAAGCTGCATTCTTGCTTCCCTCATCCTCATCTCAACGCATCCATGCATGTTTGGGCGCATCCTGAATTANGTCAGACTGCAGGCGCTGGGC CGGCAGTGCTCGTGTATCAACCACAACTTGGGGCGT Clone Rv137 ::::::::::::::Rv137SP6.seq:::::::::::::: TTCCAACCCTAATTGGCTTTCGGCCCCATCCGTGAGGACGGGGTGCGGGTGCTCAACAACAACGTCGTCCGCGGGACACACCTCTATGCTGCCGCCATGGACGCGG (SEQ ID NO. 72) TCCAACGCAAGCAGCTGATCGAGCTACAACCCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGCATCGCCGTGATCGTCGATGACGG CATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCACGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCAAACGACATCGTGGCG AGATTCGCCGGGTACGCCGATGAGGTGGTGTGTCTGGCGACGCCGGCGTTGTTCTTCGCCCTCGGGCAGGGTTACCGCAACTTCAC ::::::::::::::Rv13T7.seq:::::::::::::: CAGGCATGCCAGCTTTCCGCCGATACCCGCCATGTCGCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGcGQATGATCGGGCCG (SEQ ID NO. 73) CCTACGTCGTGGTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAA GGCCTATGTCACCGGTCCGGCAGCACTCAATGCCGACCAGGCCGAGGCCGGAGACAAAAGTATCGCTAAGGTCACCGCCGATCACNAGCATGGTGATCGCAGCAAT GTTGCTAGTGATCTATCGCTCCGTAATTACCGCGGTTCTCGTCTTGATCATGGTCGGCATCGACTCGGCCAATCCGCGGATTCATCGCCrTGCTCGCCGAACACAA CATTTTCACCTTTCACATTTGCACCAACCTGCTCTTCTCAT Clone Rvl38 ::::::::::::::Rv138SP6.seq:::::::::::::: CACTACTCAAGCTCTCTCNTCATTACCACCCCTGTAATTTGGGATGGGCAAAAAGGCGAAGCACCGCTTGGCCACNAACGCCGGGAGGGACAATCTCGGGCGGCTA (SEQ ID NO. 74) TGGCTTCTCCCGGGAAGGCCCCAACGTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATTGGCACCAACCTGNTACCACCCTGGCCGG GCGATGATCTGCAGCGTCGCCGCGGGTAGTCCCCGCCCGGGCGGCTACAGTCTGAAACCCCGATGACCATCGATGTGTGGATGCAGCATCCGACGCAACGGTTCCT ACACGGCGGATATGTTCTCCTCGCTGCGCCGCTGGACCGGTGGGTCTATCCCCTGAAACCGACATCCCN ::::::::::::::Rv138T7.seq:::::::::::::: CAGGCATGCAAGCTTTCGTCAGTTCATTGCGCCAGCAGACCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGA (SEQ ID NO. 75) CGGCGCGAACGACGCCAGCGACCACATTCAGCAGATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCrACTCCCAGGGTGCGGCCGTGATCGACATC GTCACCGCCGCACCACTGCCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGACGATCACATCGCCGCGATCGCCCTGTTCGGGAATCCCTCGGGCCGCG CTGGCGGGCTGATGAGCGCCCTGACCCCTCAATTCGGGTCCAAGAACATCAACCTCTGCAACAACGGCGACCCATTTGTTCGGACGGCAACCGGTGGCAACGCACC TAAGCTACCTGCCCGGGATGA Clone Pv139 ::::::::::::::Rv139SP6.seq:::::::::::::: GTTTATGCACTGGTTAGGTGTTTCCATGAGTTTCATTCTGAACATCCTTTAATCATTGCTTTGCGTTTTTTTATTAAATCTTGCAATTTACTGCAAAGCAACAACA (SEQ ID NO. 76) AAATCGCAAAGTCATCAAAAAACCGCAAAGTTGTTTAAAATAAGAGCAACACGTACACAAGGAGATAAGAAGAGCACATACCTCAGTCACTTATTATCACTAGCGC CCGCCGCAGCCGTGTAACCGAGCATAGCGAGCGAACTGGCGAGGAAGCAAAGAAGAACTGTTCTGTCAGATAGCTCTTACGCTCAGCGCAAGAAGAAATATCCACC GTGGGAACTCCAGGTAGAGGTAC Clone Rv13 ::::::::::::::Rv13SP6.seq:::::::::::::: ATACTCAAGCTTGGGTGTAGCCGATCACCGGAAGTCNCATGATCAGCCACGTTCCGCGCCGCCCGGCATACGGTGGTGTACCGATCTCCGCGTCATACACCCGCGG (SEQ ID NO. 77) GTAATCGCCGACGGTGCCGGTTCGGGAGCCAA ::::::::::::::Rv13T7.seq:::::::::::::: AGCTTTATCTGAAAGCGAACAGCTCGCGGCGGCCCACGACGTGCTGCGTCGGATTGCCGGGCGGCGAGATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCT (SEQ ID NO. 78) GGCCCGCAACGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGCCCGGTCGGCAAG CCCGGCAGTTGCCAAACCCATCGTGATCAGGCTCGGCTCGCGAGTTCGGCGAAGAAATGGTTCGCCTGATCACCTACCATCGGCCA Clone Rv140 ::::::::::::::Rv140SP6.seq:::::::::::::: TCAACACGCCGCCAGCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCTCCAGGCTNCTCCGCTCGGTGATGGCACGCCACCGCGACACCACCCGGCTGCGCTAC (SEQ ID NO. 79) GTCGAGCCATACCGGGCGGAGCTACATCGGCCCGGCCGCCCAGTGTTCGGGCCCTCTCGCCCAGGTCGAGGTCGACACCGATTTGCGCATCCGCAGCCGCACCCTG CGACGACAGAACCGCGGCCCTACCCACTGCTTGTCGGGCGGGGGCCAAAGAACCAGCTTGNCATCCTGCCACAATTGGCCGGCGCCG ::::::::::::::Rv140T7.seq:::::::::::::: CAGGCATGCAAGCTTCACGTCCGTACGGCTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCAC (SEQ ID NO. 80) ACCTTCAGTTGCTCACCGGAATCCAACCGGTAGAAGGTCGGCCAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCA GCACTCCGCAGGCTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCACGTAGACGGTTCCTTTCCTAAGCAA CAC Clone Rv141 ::::::::::::::Rv141SP6.seq:::::::::::::: AATATTCAAGCTTTCGGCGGAAACGGACNCCTTGCGAACATTGATAACAAAATAGAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAA (SEQ ID NO. 81) ATTCCAATCAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCCGTCNTTATCAGCCNAAATAACTGCTCTCGGGTACCACCCAAACAGCGCAATA TGGCGAAAAACGGTCGCCGTTGCACAACATTAAATGTCTCGGTATTGTTGATTAAAAAGATACCCACCACCAGGGCAATCCAACTGAGAGCGGTTAAATTGACCGT AAAAACCTCCCGTCATCTGTTT ::::::::::::::Rv141T7.seq:::::::::::::: CAGGCATGCAAGCTTGCTGCATCTTCCTGTGACTGCTCCCGAAACCTGGGGGTGTGCCTGCTGTGTATGCACGGCATACGGACATCCTTCCCCTGATACCCGCGGT (SEQ ID NO. 82) CGAACCAGCCACGTGTCCATCATCAGGGGTCAACCCCGGCCAAGGGCGACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGAG CAAAACAGCTGGTCGGCCGTTAGGAACTGAATTGAAACTCAACCGATTTGGTGCGGCCGTAAGTGTCCTGTCTGCGGGTGCGCTGGTGTTGTCCGCGTGTGGTAAC GACGACAATGTGACCGGGGGAGGTGCAACCACTGGCCAGGCGTCCGCGAAAGTCCATTGCNGGGGGAAGACAC Clone Rv142 ::::::::::::::Rv142IS1081.seq:::::::::::::: GAAAGTGCCCCAAGGTGTTGGTGAAACTCGCTGGACGGTCCCCAGGATGTTGGCAGCACATTCACCGGACATGACCGGAGCAAGACCGGACATCCTCCCATACCGT (SEQ ID NO. 83) CGTCGCCGTGTACATCCGTAGCCCGTCCTGGCAGGTGCTGGGTTGAACAAAATCAGCCCAACACCTGCCACGACGAAGAAGCGGGTTGCGCTGGCATGTCTTGTCG GCTCGGCGATCGAATTCTACGAATTCCTTATCTACGGGACCGCTGCGGCGCTGGTGTTTCCCACCGTGTTCTTCCCACACCTGGATCCCACGGTGGCCGCCGTGGC CTCCAAGGGGACATTTGCTGTGGCGTTCCTATCCCGGCCGTTCGGCGCGGCCGTCTTTGGATACTTTGGAGACCGCCTCGGCCGCCAGAAGACCCTGGTCGCCACA CTGTTGATCATGGCCCTGGCAACCGTGACTGTTGGGCTGGTTCCACGACAGTGGCCATCGCGC ::::::::::::::Rv142SP6.seq:::::::::::::: ATATTCAAGCTTTGTCACACCAAGTGTTCCGACCAANCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCA (SEQ ID NO. 84) TCTCGCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCTGGCGCAGCTTGGGGATCGCGACGTCGATGGTTGCGGCACGGGTGTCGAAATCACGGTGGC GGTAGCCGTTGCGCTGATTGGACCGCTCATCGCTGCGTTCGCGGTAGCCCNCCCCGCACAGGGCGTCGGCTTCAGCCCCCATCCAAGGCGGCGATGAACGTCGAGA GCAGCCCGCGCAGCAMTCCGGGCTCGCCTGTGCGAGTTGGTCAGCCAGAAGCTGCTCGGTGTCATMGATGAGAAGAGGTCAGTGCGTCCTTTCCTTCG ::::::::::::::Rv142T7.seq:::::::::::::: CAGGCATGCAAGCTTTTTGAGCGTCTCGCGGGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGC (SEQ ID NO 85) CCACCCTCATTGGCGATGGCGCCGACGATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGTCAAGTCCGGTCTACGCTTGGGCCTTT GCGGACGGTCCCGACGCTGGTCGCGGTTGCGCCGCCAAAGCGGCGGGTCGGGTGCCATCATGAATGCCTCACCGCCGCCGCACTGCACGGCCAGTGCCCCGGCQAT GTCAGCCATCGGGACATCATGCTCGCGTTCATACTGCTCGACCAGTCCGCGGAACAGCTCCATTCCACCGCCCAACGC Clone Rv143 ::::::::::::::Rv143SP6.seq:::::::::::::: ATACTCAAGCTTTTGGCTGGGTCGGCTTCCAATTCAGCGTGCACCGCTATGGGTTGCAGCAGCGGCTGGCNCCGCACACCCCACTGGCCCGGGTGTTTTCGCCCCG (SEQ ID NO. 86) AACCCGGATCATGGTGAGCGAAAAGGAGATTCNCCTGTTCGATGCTGGGATTCGCCACCGCGAGGCCATCGACCGATTACTCGCCACCGGGGTGCGAGAGGTGCCG CAGTCCCGCTCCGTCGACGTCTCCGACGATCCATCCGGCTTCCGCCGTCGGGTGGCGGTAGCCGTCGATGAAATCGCTGCCGGCCGCTACCACAAGGTGATTCTGT CCCGTTGTGTCCAAGTGCCTTTCGCGATCGACTTTCCGTTGACCTACCGGCTGGGGCGTCGGCACAACACCCCGGTGAGGTCGTTTTTGTTGCAGTTGGGCGGAAT CCGTGCTCTGGGTTACAGCCCCGAACTCGTCACGGCGGTGCGCCGCCGAC ::::::::::::::Rv143T7.seq:::::::::::::: CAGGCATGCAAGCTTCAACCTATTGACGCATTGTGCGAACTGACGGCGCCCGCGCATGGCCAATCCGGAAGACCATCATTGGCCAGTGGCCGGGCGCTAACAGGTT (SEQ ID NO. 87) CCAGCCCCCCACCAGTGCCCCTCGAACATGCGGTGCAACCCATTCGCAGGCCGGCAGGGAAAGCACCGCGGAAGCCGCAAAGGGCTGCAGTTCCGCGCCCAATAGT GTCGTCCGCAACCAGATGCGCTCGAAAACCGCCGCCGGCAGTCAGCGCACCCGACGCGAGGTCGAGAGACGTCGTCAGCGCGCCCACATGGGGTGCCAATCGGCAC GGCAGGTAGGCCGCGCGCAACCCCAACGGGTGGTGCATGCCACGGTCCGCAGGAGGCCACCACCC Clone Rv144 ::::::::::::::Rv144SP6.seq:::::::::::::: ATACTCAAGCTTCCCGGCCGCAGGTGACGGCGCGGCCTAGCGCCACTTGATGCCGCACCCGATCGACGGNCGTTCGGTCGGGGTTGACTGGCCGCCCGGCGAAGG (SEQ ID NO. 88) GCGTCAACCGCGGCCCGGACGTCGGCGGCCGTCACCGGTCGGCCATTGCCCGGCGGGAGTCGTCGAGCTGACCACGGTAGACAAGTCGGCGCTGGCCGTCGAAGA CAAACGTGTCGGGTGTGCAGGCCGCGGAGAAGGCGCNGGCGACGTCTCGGGTTTCGTCGTAGAGATACGGGAACGTCCAGCCGTGGCGGCGGCCTCGGCGACCAT CTGATCGGGCCCGTCCTGCGGGTAGGTGACCACGTCTTACTGGAGATACCGACCATCGGGACCCTTTGATCGGCGAGGTCCCGGCCGACCGTGGCCAATCCGGCG GCGACGTGTCGCCCGTACCGGCCAGTGGTTC ::::::::::::::Rv144T7.seq:::::::::::::: CAGGCATGCAAGCTTTANCANCATCAACCCCGCCCCGCACCAGCACCGACACGATGTCGATGCCATCGAGGTGAATGTCGAACTGGCNCAAACCATCTGGCGACCG (SEQ ID NO. 89) CGACCACCGGCAACATGGGTACCGGCGATTTCCGGTGCCAATGCCGACCCGACGGGCCGCTCTCACCGCAGGTGACCTCGATCACCGAGACCAGCCGGCCGTTATA CTCACGCACCCCTACCGTGTCACGCCCAAAACGGCGCTGGTGGTCGATTGCCGGAGTGCACCCCGCACCCAGTGTCGTGCCCGGATCCGCCGACCAATCCCGCACC GGCTG Clone Rv145 ::::::::::::::Rv145T7.seq:::::::::::::: ATATTCAACCTTGCACACATTGACGATACCTTGGTCACGAGACCCCAAAAGCTGGCCTCCACCGCGCGCCGGGGACCACGGTCATACCTTGANNCNGCTTTCGATC (SEQ ID NO. 90) GTTGATGCTGCGTCTTGGTCCGCGGAAACCGCAGGCTGGCATATGCACGTGGGCGCACTGGCGATCTGCGATCCCCACCGATTCGCCCGAATACAGCTTTCAGCGG CTCCCCCAAGTTGATCATCGACCGGCTGCCGGATATCCCGCACTTGCGGTGGCGGGTCACCGGCGCCCCGCTCGGACTGGACCGGCCGTGGTTCGTCGAGGACCACG AAC ::::::::::::::Rv145T7.seq:::::::::::::: CAGGCATGCAAGCTTCATGCCCGCGGCATGATAGCCACATGCACGCAATCGAACTCAGCGAAACCGGCGGGCCAGGCGTCTTACGCCACCTCACCAGCGCGCAACC (SEQ ID NO. 91) TCAACCCGGGCACGGAGACCTCCTGATC Clone Rv146 ::::::::::::::Rv146SP67.seq:::::::::::::: ATACTCAAGCTTGATTTTGATCATCATGATGATCATCACCCGAATTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGG (SEQ ID NO. 92) CTTTCCGTATTGGTCTGGCAGGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCNTGGCGGTGGGATCCGACTACAATCTGC TGCTGATTTCCCGGTTGAAAGAGGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGG&AGTGGTGACGGCTGCCGGCATGGTGTT CGCCGTTACCATGTCGTTGTTTGTGTTCAGCGATTTGCGAATTATTGGTCAGATCGGTACCACCATCGGCCTGGGCTTGCTGTTCGACACCCTCGTCGTGCCTCGT TCATGAAACCGTCCATTGCTGCCCTGCTGGGACCTGGTTCTGGTGGCCGCTACGGGTGCGCCGCGCCCGGCAGTCAAATCTTCCGCCG ::::::::::::::Rv146T7.seq:::::::::::::: CAGGCATGCAAGCTTGGCGTGCCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACC (SEQ ID NO. 93) TCGATGCTGCCGCCATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGGGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCG GATCGCGGTGATCGTCGATGACGGCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAACGTGGTGCTGGCGGTCCCC ATCGGCCCAGACGACATCGTGGCGAGA Clone Rv147 ::::::::::::::Rv147SP6.seq:::::::::::::: ATACTCAAGCTTTTACGGTGATCGCGATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCG (SEQ ID NO. 94) GGTGCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGAC TGTCCATGGACAACAGCGCGTTCTCCACGACCGGGCCCGGGTGTGGGGTGTTTCGGCGACCGGCAGCCANGTGGTCCACACTGCCGAAG ::::::::::::::Rv147T7.seq:::::::::::::: TAGTCGCTGACCGGTGCAGGTTTCGACNATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTTATCGGCTACGAGCAAA (SEQ ID NO. 95) TCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCTANCNTGTGTGCCGCGGATTATCAGG ACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGG Clone Rv148 ::::::::::::::Rv148SP6.seq:::::::::::::: ATACTCAAGCTTTCCGCCGATACCCGCCCATGTCGCGCACATCCAGAACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAGTGCGGATGATCGGGCCGCCT (SEQ ID NO. 96) ACGTCGTGGTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACGGCACGGGGTGAAGGC CTATGTCACCGGTCCGGCAGCACTCAATGCCGACCAGGCCGAGGCCGGAGACAAAAGTATCGCTAAGGTCACCGCGATCACGAGCATGGTGATCGCAGCAATGTTG CTAGTGATCTAATCGCCCCGTAATTACCGCGGTTCTCGTCTTGATCATGGTCGGCATCGACCTCGGCGCAATCCGCGGATTCNTCGCCTTGTCGCCGACCACAACA TTTTCAGCCTTTCAACATTTGCGACAACCTGCTCGTTCTCATGGCGATTGCNGCGAAC ::::::::::::::Rv148T7.seq:::::::::::::: CAGGCATGCAAGCTTGGCGTGCCGTTCCAACCCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCTGGACACAA (SEQ ID NO. 97) TCGATGCTGCCGCCATGGACGCGGTCGAACGCAAGCACGTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCG GATCGCGGTGATCGTCGATGACGGCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCG ATCGGCCCAGACGACATCGTGGCAGATTCGCCGGTACGCCGATGAAGTGGTGTTGTTTGGCGACCCGGCGTTGTT Clone Rv149 ::::::::::::::Rv149SP6.seq:::::::::::::: ATACTCAAGCTTTGGCATTGTGCACATTTTCCACCCGTGCTCTATTAATGCTGAGCCGCTAATTGTGACCCCAGTCGGGAAACACGCGGAGCACCAAATTCACCGC (SEQ ID NO. 98) AGCGGCCGGGGCGGTTCAACTCACCATGGATCGCTCTCGTCGTCTGGTGCTGGACAATCGTCGCTGTAGCGCGTCGCGAACACCTCAGCTTCTGCTGCCGCGGCTT CTTCCGGCGATGGTAACCCCCAGGTTTCGCCCACGGTCTTACGTAGCAGTGCGACGCGGTGTTCATCTGCATCGACCTGTTGACTCATCCTGTCAAGGATGAAGGC GTACTGGGCCGACTGCGCCTTCTGCCGCGCCAGGTCGGCAATCACCAGGATCTCAGAAACGAGCTGCGACTCACTCTTCCAGGCCACCCTGGCCGAAAGCTCGACA TGGTCAATCCGGCCG ::::::::::::::Rv149T7.seq:::::::::::::: CAGGCATGCAAGCTTGCGGGCCGGAGTGGTTTCGACGGCCGCTCGCTTCTCGGCATCGGTTTGGGCTGTCACCAGCAGTTGGTAGTTCTTCACGTACTGTTGTTCG (SEQ ID NO. 99) AGCGTCGAGCCGCCGCGCGTGTCGAGGTCGCCGGACGCGTATCCCGCCAGGCCGGTCAGGGTGCCCTTCCAGTCCACGCCGCTGTGGTCGGCGAACCGCTTATCTT CAATCGAGACGATCGCCAGCTTCATCGTGTTGGCGATCTTGTCCGAGGGCACCTCGAACCGGCGCTGCGAGTACAGCCACGCGATCGTGTTGCCCTTCGCGTCGAC CATCGTCGATACCGCAGGCACTTGCCCCTC Clone Rv14 ::::::::::::::Rv14SP6.seq:::::::::::::: ATACTCAAGCTTCCCGGCGGCCAGTACCGAAAGCGCGAACAGCTCGCGGCAGCCCACGACGTGCTGCGTCGGATTGCCGGCGGCGAAATCAATTCCAGGCAGCTCC (SEQ ID NO. 100) CGGACAATGCGGCTCTGCTGGCCCGCAACGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGC TTGATGCCCGGTCGGCAAGCCCGGCAGTTGCCAAACCCAGCGTGATCAGGGTCGGCTCGCGAGTTCGGCGAAGAAGTGGCTCGGCTGATCACCTACCATCGGCCAG GATCTGCGTGTCATCACAACGCTCGCCAAGGAGGTTGTTGTGGTGCTATCGACGGCCTTTAGCCAGATGTTCGGAATCGACTATCCGATAGTGTCCGCGCCAATGG ACTTGATCGCCG ::::::::::::::Rv14T7.seq:::::::::::::: AGCTTCGGTGTAGCCGATCACCGGAAGCCGCATGATCAGCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTAATCG (SEQ ID NO. 101) CCGACGGTGCCGGTTCGC&AGCCGAAGGTGACGACGCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGTCAATCACGT TGTCGCTTTCTACGGTCACCGACGCCGTGACCGTAGTCGCCCGGTGCGCTCGGCCGAGAAGTTGCACCGCCACCACCGCGACACCGTCTTGCACGCGGACCCCACC CCCGGATCGGTTGTTGGCCAAGGTAATTGGGTCATTCCATTTGACGGGACGCCGACCCCGCAGCCCCAGTACCGCCCACGACCACGCCGGCTGACCCACCACTGTA CGAACACCAAGGCGACGCCGA Clone Rv15 ::::::::::::::Rv150SP6.seq:::::::::::::: ATACTCAAGCTTCGGTGGCTTCGCCCGCCCTGCCGGGTGGACTTCATGACAACGCGGGGGCGATTACCCCCGCTACCGCCAGCAGCATGACGGCGGTACC7AACAC (SEQ ID NO. 102) CGCCCGGATGCCTCGCACGTGCCTCGATGTGCTCACGGAATCGCCCCGGCACCGCGATCTCGAGGATCACCAGCGTTACCCCCGGCAGCGCGACACCGACAATTCC GTACACCGCCACGCCGATCCGGCCCTGGGCCAGCTGATTGGAGCTGGCG ::::::::::::::Rv150T7.seq:::::::::::::: CAGGCATGCAAGCTTCCACATGTACGGATCCACGAACATCCCGTTGAACTGACAGGTGCGGCCCGGCTCGATCAGGCCGGCCACTTGTTCTACGCGGTTACCGAAG (SEQ ID NO. 103) ATCTCTTCGGTGACCTGCCCGCCGCCGGCCAGCTCGGCCCAGTGCCCGGCGTTGGCCGCCGCGGCGACGATCTTGGCGTCCACGGTGGTCCGGGTCTTGCCCGCTA GCACGATCCGCGAGTCGGCCGGTCACCCGGGT Clone Rv151 ::::::::::::::Rv151SP6.seq:::::::::::::: ATACTCAAGCTTTCCAAGTCCCAAGTGTCGATCATGGCCAAAGAGCTCGACAAAGCCGTAGAGGCGTTTCGGACCCGCCCGCTCGATGCCGGCCCGTATACCTTCC (SEQ ID NO. 104) TCGCCGCCGACGCCCTGGTGCTCAAGGTGCGCGAGGCAGGCCGCGTCGTCGGGGTGCACACCTTGATCGCCACCGGCGTCAACGCCGAGGGCTACCGAAAGATCCT GGGCATCCAGGTCACCTCCGCCGAAGACGGGGCCGGCTGGCTGGCGTTCTTCCGCGACCTGGTCGCCCGCGGCCTGTCCGGGGTCGCGCTGGTCACCAGCGACGCC CACGCCGGCCTGGTGGCCGCGATCGGGGCCACCCTGCCCGCAGCGTGGCAGCGCT ::::::::::::::Rv151T7.seq:::::::::::::: CAGGCATGCAAGCTTCACACGTAGGCGCGTCGATAAATGACTCCGCCGCGCTTCGCACATCCTCGTAGCGATCCTTGGCGAGCAGGTCAACCGGGCGCTGCCCGT (SEQ ID NO. 105) CGAGGAGCCGGTTTTTGGCGTGCAGCCACTGGCCGACACCTCGGGGGGTAGGCGAATCCGAGAGCAGGAGGACGAGGTCACGGAGCTGCGCCAGCCGGTCGTACCG CTCAGGGCGGATGTCGCCGGTCCGCCACCCGCGTACCGCCCGATCGGACACCTGTATGACCGCGGCGACGTC Clone Rv152 ::::::::::::::Rv152SP6.seq:::::::::::::: CGCGGCGGCGCATTACCCCCGCTACCGTCAGCAGCTTGACGGCGGTAGCGAACACCGCCGGATGCAGCGCAGGTGCGTCTATGTGCACACGGAATCGCCCCGGCAC (SEQ ID NO. 106) CGCGATCTCGAGGATCACCAGTGCCCGCCCCCTG ::::::::::::::Rv152T7.seq:::::::::::::: GGGATCGAGGAACAGCGCGTTGAACTGATAGGTGCGGCCGGCTCGAGCAGGCCGGCCATTTGTTCGATGCGGTTACCGAAGATCTCTTCGGTGACCTGCCCGCCG (SEQ ID NO. 107) CCGCCAGCTCGGCCCAGTGCCCGGCGTTGGCCGCCGCGGCCGACGATCTTGGCGTCCACGGTGGTCGGGGTCATGCCCGCGAGCAGGATCGGCGAGCGGCCGGTCA GCCGGGTGAACTTCGTCGAGAGCTTGACCCTG CGTCGGGGAGGCGAACCACGGTCGGTGCGTATCTCGACCAGGCCCGGGCAACCTCGGGGGTGGCGCCGACGGT GAACAGGTTGCGCTGGCCACCACGGGTAGCCGCCGGCACTATGCCGATGCCCAGGCCGCGGATCACCGGTGCGGTCAGTCGGGTCAGGATGTCGCCCGGCCCCAGG TCGAAGATCCAGCGGGCGCCGGCCGCGTGGACACNGGTGATCTCGTCCACCATCGACTTTTCTGATCA Clone Rv153 ::::::::::::::Rv153SP6.seq:::::::::::::: TAACTCAAGGCTTGCGTTGAGGCCCCAGGCCCATCGACGGTTTGGCGGCCTTAAATGCACTGAGGTCGTCAATTGACCCCACAGCGGAAATGCCGACTATTCGCAG (SEQ ID NO. 108) GCCTCCTTCGCCTTGGCTGCCGGAGAGGGGCTCCGCGGGAACCGCATGCAGGTATATGACCTCGGTTTCTCGGGTGCTACCGGGTGCCTTGTCGAGGATGAACTCG GCGTTGGAATTGTCCAGCCGGCCCAATTCATCGAGCGCAGATTCGTACACATGGCCGGCGGCGACATACGCTTCACCGTGGATCTGCTCCACACGGAGCGGCCTGT CGGGATCCTGCTCACGGGTAAAGGAACTTACNTGGCNCTCGGTGCC ::::::::::::::Rv153T7.seq::::::::::::: CCTTCTGCGCCACCCACACCGTCAACGCCCGCGAAGTCGACGTCGTCCAGGCCATCGGCGGCCTCACGGATGGATTCGGCGCGGACGTGGTGATCGACGCCGTCGG (SEQ ID NO. 109) CCGACCGGAAACCTACCAGCAGGCCTTCTACGCCCGCGATCTCGCCGGAACCGTTGTGCTGGTGGGTGTGCCGACGCCCGACATGCGCCTGGACATGCCGCTGGTC GACTTCTTCTCTCACGGCGGTGCGCTGAAGTCGTCGTGGTACGGCGATTGCCTGCCCGAAAGCGACTTCCCCACGCTGATCGACCTTGACCTGCATGGCCGGCTGC CGCTGCAGCGGTTCGTTTCCGAACGCATCGGGCTCGAAGACGTCGAGGAGGCGTTCCACAAGATGCATGGCGGCAAGGTATTGCGTTCGGTGGTGATGTTGTGATG GCCGCCATCGAGCGCGTCATCACCCACGG Clone Rv154 ::::::::::::::Rv154SP6.seq::::::::::::: ATACTCAAGCTTGATTTTGATCATCATGATGATCATCACCCGAAGTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGG (SEQ ID NO. 110) CTTTCCGTATTGGTCTGGCAGGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGC TGCTGATTTCCCGGTTGAAAAAAGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTTACCGCTGCCGGCATGGTGTT CGCCGTTACCA ::::::::::::::Rv154T7.seq::::::::::::: ATTGNCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCGGTCGAACGCAAG (SEQ ID NO. 111) CAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTCGATGACGGCATCGCCACCG GAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCAGACGACATCGTGGCGAGATTCGCCGG GTACGCCGATGAGGTGGTGTGTTTGGCGACGCCGGCGTTGTTCTTCGCCGTCGGGCAGGGTTACCGCAACTTCACCCAGACCTCCGACGAAGAAGTGGTGGCGTTT TCTGGATCGTGCTC Clone Rv155 :::::::::::::Rv155SP6.seq::::::::::::: ATACTCAAGCTTTTCCCGTCCGTCATCGCCCAAGCGCGTGAGGCCGAAGCGGCTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGG (SEQ ID NO. 112) GGACGCCCGACCAGCCGATGCTGGAGGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCG CAGCCCGACCCTGCTGGCAAAGATCATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGAGCTGGAACACCGCCAG CTCGGCTTCGAGTTCGGCACTTTCAGTGACCGGTTCAACCGGCTCGAANAGGCGCTACAGATCCTCGAGCCAATGGTCAAGGGTGAGCGCCAACGTTTTTCGGCGA TTGGTACCCACCGA :::::::::::::Rv155T7.seq::::::::::::: CGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGAC (SEQ ID NO. 113) CCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACG ATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACT TGAAGGTGATTGTTAACCTGGGCTACGGCGACCCGGCCTATGGTTATTCGACCTCGCCGCCCAATGTTGCGACTCCGTTCGGGTTGTTCCCAGAGGTCAGCCCGGT CGTCATCGCCGACGCTCTCGTCGCCGGGACCAGCAGGGAATCGGCGATTTCGCCTACA Clone Rv156 :::::::::::::Rv156SP6.seq::::::::::::: TCGCCACCGCACCGCGGCGAACGCTCAAAGGCACCTACTGGCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGCGCCGACCCCGCCCGAGGTCCTGGCCGTTA (SEQ ID NO. 114) CCACCGAACGGGCGAGCCGGGAGTCTGGTACGCATCGAACAAAGAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGGTCGATCCATTCGAG GTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCAGGTACTCGACCTCACAGACGAGAGGACTCGATCCCATCTAGGTGTGGACGAAACAGATCTTCTGTCCG ACGACTACACCACCACCCAGGCCATCGCCGCCGCCCGCGATGCCAACTTCGACGCCGTACTGGCCCCGGCGGCGGCGCTCCCCGGTTGTCAAACACTTTGCCGTGT AATCCCATGACGTATCTGCGCAACGACGTGCNCAACNGTGGCTGATGTCNGTGGTGTTGTGGGGTGGGC :::::::::::::Rv156T7.seq::::::::::::: TCGCCACCGCACCGCGGCGAACGCTCAAAGGCACCTACTGGCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGCGCCGACCCCGCCCGAGGTCCTGGCCGTTA (SEQ ID NO. 115) CCACCGAACGGGCGAGCCGGGAGTCTGGTACGCATCGAACAAAGAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGGTCGATCCATTCGAG GTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCAGGTACTCGACCTCACAGACGAGAGGACTCGATCCCATCTAGGTGTGGACGAAACAGATCTTCTGTCCG ACGACTACACCACCACCCAGGCCATCGCCGCCGCCCGCGATGCCAACTTCGACGCCGTACTGGCCCCGGCGGCGGCGCTCCCCGGTTGTCAAACACTTTGCCGTGT TCGTTCACGCACTGCCCAACATCGAGCCCGA Clone Rv157 :::::::::::::Rv157SP6.seq::::::::::::: ATGAAATAAGAAGAGCACATCCCTCAGTCGGTTATCATCACTAGCGCTCGCCGCACCCGTGTAACCGATCATAGCGAGCGAACTGGCGAGGAAGCAAAGAATATCT (SEQ ID NO. 116) GTTCTGTCAGATAGCTCTTACGCTCAGCGCAAGAAGAAATATCCCCCGCGGGAACAACTCCAGGTAGAGGTACACACGCGGATAGCCAATTCAGAGTAATAAACTG TGACACTCACACCCTCATCAATGATGACGAACTACACCCCGATATCCGGTCACATGACGAAGGGAAAGAGAAGGATATCATCTGTGACAAACTGCCCTCAAATTTG GCTTCCTTAA Clone Rv159 :::::::::::::Rv159SP6.seq::::::::::::: ATACTCAAGCTTGTCGAACTCCTTCTTGAATACCGGCCGGCCATCCACAGATGCCCGGAAGAACTTCCAGGTACCCATGGCGGCTGGATCAGGGGGCGGCACAGTT (SEQ ID NO. 117) GGTCTTGTCCTGCCTCGAGTGGCGTCGTTGTCCGGCTTGGACGGGGCTCCGACGGTACCGGAGGGCAGCGACAAAACACTTATGCACTTGGGCGACCCGCCGAGAC GGTGCGACACCCATCCCGACGGCACAAGCTCAGCCGCGGCCGCTCTTGTTCTTCGTCGGATCGACATTCACCCACTTCTGACCGGGCTTGGGCGAAGGAAGCAGAA :::::::::::::Rv159T7.seq::::::::::::: GGTATAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTTATCGGCTACGAG (SEQ ID NO. 118) CAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCAAGCATGTGTGCCGCGGATTAT CAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGGATAGCGAGGTCAGCGAATTCTCGTGGCA GCTCGAAAGGGTCCTGCCGGTGCCGGTCTTTGCGCAAACGATGGCGCAGGTTACGGTCGCGCGGGGTGCGGCCCTGGCGGCGGCCCA Clone Rv15 :::::::::::::Rv15SP6D2.seq::::::::::::: GACACTATATNATACTCAAGCTTCAGGTCAATGTGCGCCAAGCCCTGACGCTGGCCGACCAGGCCACCGCCGCCGGANCCCTNTCTAGA (SEQ ID NO. 119) :::::::::::::Rv15T7.seq::::::::::::: CTGTAGCCACCTGTTGCCATCCCCGTCATGCCCGACTCTGGTCATCTCGGATCCGCTGACACCCCGCTAAGGCTGCTCCTCTCGGTGCATTACCTCACCGACGGCG (SEQ ID NO. 120) AACNCCCCCAGCTTTACGACTATCCGGATGACGGCACCTGGTTGCCGGCTAACTTCACCGTCAGCTTGGACGGCGGCGCTACCGTCGATGGCGCCAGCGGGGCGAT GGCCGGGCCCGGCGACCGATTCGTCNTCANCCTGTCGCGTGAACTTGCCGACGTCATCGTGGTCGGTGTGGGCACCGTGCGCATTGAGGGCTACTCCGGCGTCCGG ATGGGTGTCGTCAAGCGCCCGCACCGGCAGGCCCGA Clone Rv160 :::::::::::::Rv160SP6.seq::::::::::::: ATACTCAAGCTTCGCACGCTCGGCGCGCGCGGTACCGCCCAGGTCGCCCAACAGATCGTCGATGTTCGCGTCGTCCGCCTCGCGCACGTGGTCTGTCACCAGTCAA (SEQ ID NO. 121) CGTTAACGCCGCCGCACATGTCCTGCGGCCGGGCAAAAACGTGAAAAACGAGCGGGCGACTGCNATGTCATGACACCGACGGCCGCCGATGGGCCCAGGGTCTGGC AAATTCGATCTGTGCGGCCAGTGCCAGCAGCGTCGCCTCGTCATACGGCCGGCCGACGAGTTGAACCGACATGGGCAGGCCGTCGCCGTCGAAGTCCCACGGCACC ACGGGCGCGGGCTGGCCGGTCAGATTCCAAAATTGAAAGTACGGAACCGCTGCACCACCAA :::::::::::::Rv160T7.seq::::::::::::: ATCGTTTCGACCAGGCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCAGCTCGCTTGCGGCGCTGCAGCA (SEQ ID NO. 122) GCCAGTCCGGGAAATAGCTGCCCTGGCGCAGCTTGGGGATCGCGACGTCGATGGTTGCGGCACGGGTGTCGAAATCACGGTGGCGGTAGCCGTTGCGCTGATTGGA CCGCTCATCGCTGCGTTCGCGGTAGCCCGCCCCGCACAGGGCGTCGGCTTCAGCCCCCATCAAGGCGGCGATGAACGTCGAGAGCAGCCCGCGCAGCAGATCCGGG CTCGCCTGTGCGAGTTGGTCAGCCAGAAGCTGCTCGGTGTCGATAAGATGANAAGAAGTCATTGCGTTATTTCCT Clone Rv161 :::::::::::::Rv161SP6.seq::::::::::::: ATACTCAAGCTTGGGTGTTGCCGATCACCGGAAGCCGCATGATCAGCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGG (SEQ ID NO. 123) GTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACGACGCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACNACGTCA ATCACGTTGTCGCTTTCTACGGTCACCGACCCGGTGACCGTAGTCGCCCGGTGCGCTCGGCCGAGAAGTTGCACCGCCACCACCGCGACAACGTCTTGCACGCGGA CGCCACCCCCCGGAT :::::::::::::Rv161T7.seq::::::::::::: GCGCNAACAGCTCGCGGCAGCCCACGACGTGCTGCGTCGGATTGCCGGCGGCGAGATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCTGGCCCGCAACGAA (SEQ ID NO. 124) GGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGCCCGGTCGGCAAGCCCGGCAGTTGCC AAACCCAGCGTGATCAGGCTCGGCTCGCGAGTTCGGCGAAAAAGTGGCTCGCCTGATCACCTACCATCGGCCAGGATCTGCGTGTCATCACGACGCTCGCCAAGGA GGTTGTTGTGGTGCTATCGACGGCCTTTAGCCAGATGTTCGGAATCGACTATCCGATAGTGTCCGCGCCAATGGACTTGATCGCCGGCGGTGAGCTGGCTGCCGCN GT Clone Rv162 :::::::::::::Rv162SP6.seq::::::::::::: ATACTCAAGCTTTCTCCGATACCCGCCATGTCGCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGCGGATGATCGGGCCGCCTA (SEQ ID NO. 125) CGTCGTGGTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAAGGCC TATGTCACCGGTCCGGCAGCACTCAATGCCGACCAGGCCGAGGCCGGAAACAAAAGTATCGCTAAGGTCACCGCGATCACGAACATGGTGATCGCAGCAATGTTGC TAGTGATCTATCGCTCCG :::::::::::::Rv162T7.seq::::::::::::: CCATGAGCACCGCCAGCCGAGCACGAGGCCAAACTCCGCCGACGCAGGCCGGTTGGACTTGTCGTGCTGGACAAGGGGTTTAGCCGCCGAAGCAGTGACGTACATC (SEQ ID NO. 126) GGCGAAGAGCAGTTCGCCTGTCGACCGACGGCGCAAACCGTGAGGCTAGGGAAGCGAGGAGCACATGGCCGCCGACCCGCAATGTACACGCTGCAAGCAAACCATC GAACCCGGATGGCTATACATCACCGCCCATCGCCGCGGTCAAGCCGGGATCGTCGATGACGGCGCAGTACTGATTCACGTGCCCGGTGAATGCCGCACCCCGGGGA GCACTTTCCGCCAAAACTAACCCGGTTGG Clone Rv163 :::::::::::::Rv163SP6.seq::::::::::::: CGGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGAGGAGTGCTGAACCGTAGTCGAAGTGGGCGGCGTCAGACTCCA (SEQ ID NO. 127) CCCAGCCAGCAGGCAGCGCGAANCTGAATCCTCCAACCGGGTTGTCNATCCGGACAGGTTGGGGTGCGTTTGGGGCAATNACAGGTGGCGGCGGTGCGTTCGGGTC GGCCGGCGGAGGTGCTGCNTTGGGATCCCCGGCTGGGCATTCGGCNTGTTGGCGGCGGCCGGTGGTGGGGGGGGCAACACGTGTCNCCGGTGCGGGTGGCCCT :::::::::::::Rv163T7.seq::::::::::::: CCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTC (SEQ ID NO. 128) CAACTACTTCATCCTGACGCCGGAACAANTTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTG CCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGANACCCACTGGCGAACCTGGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGGCGACCC GGCCTATGGTTATTCGACCTCGCCGCCCAAATGTTG Clone Rv164 :::::::::::::Rv164SP6.seq::::::::::::: AGCTTCCCGAGTTCGGCTTTGGATCAAGACCCCAGTCCGCGGGCGCGATCCGGCNGCTCGGTGACTACATCAAGCCACAAATCGACGGCTTTCGGGGTGCCGATAC (SEQ ID NO. 129) CGATGACGTGGCGGATGTCGAGTGTTGAGTTCTCGGCGGGGCGGATGCTCACCTGGCGATCACCTGCCTCTCGTTGACGATCGATCGTCTATGCCGCCGTCTCTGC GGGAACAGGCCNCCAGTACATCGCCACAGACGGGATCCACCCGCATTTCGGCTACGGTTGCTCGTTTCGGTGTTCGGACTAGTCGGTCCTGGTGACGTGCCGGTGA TGCGGACCGGTCCTAGCACTGACCAATGGCCAAAATGCGGGC :::::::::::::Rv164T7.seq::::::::::::: CGGGGGGCCTCTTAATAGTGTAGGAAAGAAGCTCTACATATTCAGGAGGATTCACCATGGCTCGTGCGGTCGGGATCGACCTCGGGACCACCAACTCCGTCGTCTC (SEQ ID NO. 130) GGTTCTGGAAGGTGGCGACCCGGTCGTCGTCGCCAACTCCGAGGGCTCCAGGACCACCCCGTCAATTGTCGCGTTCGCCCGCAACGGTGAGGTGCTGGTCTGCCAG CCCGCCAAGAACCAGGCAGTGACCAACGTCGATCGCACCGTGCGCTCGGTCAAGCGACACATGGGCAGCGACTGGTCCATAGAGATTGACGGCAAGAAATACACCG CGCCGGAGATCAGCGCCCGCATTCTGATGAAGCTGAAGCGCGACGCCGAGGCCTACCTCGGTGAGGACATTACCGACGCGGTTATCACGACGCCCGCCTACTTCAA TGACGCCCAGCGTCAGGCCACCAAGGACCCGGCCAGATCGCCGGTCTCACGTGCTGCGG Clone Rv165 :::::::::::::Rv165SP6.seq::::::::::::: ATACTCAAGCTTCATAACAGGCCTGTTGTGGGCGCACCCGGCTCGCCGAGTTCTGCACGCACCGCCTCAAGTGCGGCCCGCACCGCCGGCATCTCCCGGTCACGCA (SEQ ID NO. 131) GGGCCGCGGCCCGCGCCGCAGCGACGGCGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGTTCTCGGCGTCTTCGCGTTCACTAAT CGCGGTGCTCAGCAGCGTCTCGACAGCCACCACCCGAGTGGCGACCAGCTGCTCCACCACGGACCGCAGCGATGCCGTCACCTCACCCGTCCAGCGGTCCACCACG ACACGGTCGTGCACCAGCGCGCGGGCATTCACCACCCAGGCGGTCACCGCCAGGCCGATCGCCACACCCGCCACCATCCCCGATGCAGCCAGGCCGGGAGTAAGA :::::::::::::Rv165T7.seq::::::::::::: CTGGTGCTGGACGGAGCCTAGTACAACTTCCTCTCCAATGCTCTTGCCCCGATCGCGGCGACCAGGATGACCCAGGACATCCTGCCGCCCGAAGTACTGGAAAAGC (SEQ ID NO. 132) TCACACCCGAGTTCGTCGCACCGGTGGTGGCCTACCTGTGCACCGAGGAGTGTGCCGACAACCCATCGGTGTACGTCGTCAGTGGTGGTTAGGTGCAGCGAGTTGC GCTGTTTGGCAACGACGGCGCCAACTTCGACAAACCGCCGTCNGTACAAGATGTTGCGGCGCGGTGGGCCGAGATCNCCGATCTGTCCGGTGCGAAAATTGCTGGA TTCAAGTTGTAGAACTAAAT Clone Rv166 :::::::::::::Rv166SP6.seq::::::::::::: ATACTCAAGCTTTTCCGGCGTCGTCCACCTGACCCAAAAAGCGCAGGTGCGCCGCCAAACGGCCCGCCTGGCCGCGCAACTGGTCGGCGTCGCCGTGGCCGACAAT (SEQ ID NO. 133) CAGTAGCTGGACATCCGGAAACCGCTGCACCACCTTCGGCAGCGCGTCAAGCAAAAACGGCCATTCC :::::::::::::Rv166T7.seq::::::::::::: TTTCAGATCTCATTTTTATGACATGACTGGAGATCTGTCTAGATTGCAGCTCCTGTGAGCGTGGGTACCGGATTCAAGCCGGTCGGTCACGCCGCGGTGGTACCGG (SEQ ID NO. 134) CTTTGCGGCAGTGCTCGGCCTCGAGTTCGGCGATCGCGCGCGAAGTGCGTTTCGCGCACCAAGATCGCGGCCTAATGGCCGGCGATGACCGCGATGACCAGCGCGA TCCAGGAAAAACCGTTCCAACCAGTGCTGGGCGGCCATCCCCG Clone Rv167 :::::::::::::Rv167SP6.seq::::::::::::: ATACTCAAGCTTCCCGACCACAAGTTGAACAGCACCGATTTCGGCGAGCACTTCGTCAACTTCCAGGGTGCCCGCACCAAGTATTTCGACAAGTATTTCCGTCGGG (SEQ ID NO. 135) CCGCCGCCGCCGGCGCGCGGCAGGTGGTCATCCTGGCGGCGGGGCTGGACTCCCGCGCGTACCGGCTGCCTTGGCCCGACGGGACCACGGTTTTTGAGCTGGACCG CCCGCAGGTCCTTGATTTCAAGCGCGAGGTGCTCGCCAGCCACGGTGCCCAACCGCGCGCCCTGCGCCCGCGA :::::::::::::Rv167T7.seq::::::::::::: GTGTGCTGTCAATTCAGAGCTGAGCCTGATGCACTCAACTTACTGAGCATGCTAACGCTGGTCGTGCGGGTCTTGTTCCCGCGTGTCGGCAGGGCACACGCTCGGG (SEQ ID NO. 136) GCGTAGCTGGGAGAGGCCCCGGTCAAGCCCGGAGAGCAGTGCTCAGTCCGCCAGCTTGACCGACTTTCGATGAGAACGCGCTTCTCGCCGTATTGAACTGGCGTGC TGACGGTCGCTGAGCAGCGCTCGCCGAGTGCGGCCGCTGATTCTTTCATCGAGCCAGGAGGCGCATTCGTGTTCGGCCGCCTGCGGGTCGGCCCCATCGTCGACGC GATCCGTCACCCACTCCTCGATCAGGTCTGCCTCATCGAACGGGCCAACGGTGCTGTCGGAGTATGTGTGCGTGGGCACGGCGAGCCGGGTGCTGTGGTACACCCA CCGTTGCATGACCAAGTTGACGCCTGACTGGCTGAGCACCGCGATCCGCTCACAGGTCGGAACGTTGGTG Clone Rv169 :::::::::::::Rv169SP.seq::::::::::::: ATACTCAAGCTTTTGGTCTAGCCGGCCGAGCCCGATACAGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGAGGAGT (SEQ ID NO. 137) GCTGAACCGTATGCGAAGTGGGCGGCGTCAGACTCCACCCAGCCAGCAGGCAGCGCGAAACTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGT TTGGGGCAATGACAGGTGGCGGCGGTGCGTCCGGGTCGGCCGGCGGAAGTGCTGCGTTGGGATCGCCCGGCTGGGCATTCTGCGTGTTGGCGGCGGCCGGTGGTGG GGGGGCAACAGGTGTCTCCGGTGCGGGTGGCGCTGCACC :::::::::::::Rv169T7.seq::::::::::::: GGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACG (SEQ ID NO. 138) CCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCA GTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTG ATTGTTAACCTGGGCTACGGCGACCCGGCCTATGGTTATTCGACCTCGCCGCCCAATGTTGCGACTCCGTTCGGGTTGTTCCCAGAGGTCAGCCCGGTCGTCATCG CCGACGCTCTCGTCGCCGGGACCCAGCACGGAAT Clone Rv16 :::::::::::::Rv16SP6.seq::::::::::::: TTCTNTCTTCCCNNATTCGTNNNTCTCNTACTACCNGGGCCNCAAAACACCTTGGCNAACGCTCAAAGGCGNTACNGGCACCAAGGCCCCACACGTCACCCTGTGA (SEQ ID NO. 139) CCTCCTGCGCCGACCCCGCCCGAGGTCCTGGCCGTTACCACTGAACGGGCGAGCCGGGAGTCTGGTACGCATCGAACAAAGAGCAAGGTGCATGGGCGGAGTTGTT CCGCCNCTTTTTTTATGACGGGGTCGATCCATTCGAGGTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCAGGTACTCGACCTCNCAGACGAGAGGACTCGA TCCCATCTANGTGTGGACNAAACAGATCTTCTGTCCGACGACTACACACCACCCAGGCCATCGCCGCCGCCCGCGATGCCAACTTCNACNCCGTNCTGGCCCCGGC GGCGGCGCTCCCCGGTTGTCAAACACCTGCCGTGTTCGTTCACNCACTGCCCAACATCNAGCCCGANCNATCCNAGGTCCGTCCAACGCCTCCGCGGCTCNCCAAC CTNCTCCCNCTGATCNTCCGCACCAAACACATGCCCGACTCCNTGCNCCNATTGCTTGNATCCCT :::::::::::::Rv16T7.seq::::::::::::: CCGCTATCGGTCGGTGTGCTTGGCGGCGTCGGTATCAACACCGCCCACGAAATGGGGCACAAGAAGGATTCGCTGGAGCGGTGGCTGTCCAAGATCACCCTCGCCC (SEQ ID NO. 140) AGACCTGCTACGGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCCGGGTGTCCACACCGGAGGACCCGGCGTCGGCGCGGTTCGGCGAGACGTTGTGGGA GTTCCTGCCCCGCAGTGTTATCGGCGGCTTGCGCTCGGCCGTTCATTTGGAGGCCCAACGGCTGCGTCGGCTCGGCGTCAGCCCCTGGAATCCCATGACGTATCTG CGCAACGACGTGCTCAACGCGTGGCTGATGTCGGTGGTGTTGTGGGGTGGGCTGATCGCGGTCTTCGGCCCGGCGCTGATCCCGTTCGTCATCATCCAGGCAGTCT TCGGCTTCAG Clone Rv170 :::::::::::::Rv170::::::::::::: ATACTCATGCTTGCCGAAGTTCCGATGGGTCGCGCCGGCGANCCCAGCGAAGTCGCTAGCGTGGCCGTGTTCTTGGCTTCGGATCTATCCTCGTACATGACCGGCA (SEQ ID NO. 141) CCGTGTTGGACGTGACTGGCGGCCGGTTCATATGACACCGAGATCATTGCCACGGTACGGCAATTCGTCAAGAAGGAAATCTTTCCCAATGCACCGGCCCTCGAAC GTGGCAACAGCTACCCGCAAGAAATCGTCGATCGGCTGGGTGTTATTGGCTTCGTCGGTCGCCGGCTGCAAGGGTATCGACACCACCGAGTTCATTCTCCGGGCGT GCC :::::::::::::Rv170T7.seq::::::::::::: GGCGTCAACGGTGTCGGCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCTCGTGGCCACGCATGTACAGCACCACGCCG (SEQ ID NO. 142) CGCCCCTCACGGGCGACCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGCGTGACCCAAACACATCGCCGGTCAAGCACTCCGAATGCACCCGGA CCAGCACGTCGTCACCGTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAGCGCGACATGTTCCACGTCCTCGTAGATGCTGGTGTAGCCGATGGCGCGAATCTC CCATGACGAGTCGGAATCCGCGCCTCGGCG Clone Rv171 :::::::::::::Rv171SP6.seq::::::::::::: ATACTCAAGCTTCGGCCTCGCTGCAGGAGTGGGAGCCGCAGGGCTGGAAATCCGAAAAACGAGCCGGTGATCGCACTGTCGCCGATCGGGGCCGCACCTGGTTGGT (SEQ ID NO. 143) GTTACCGATGAATCCGCACCCAAAATGTGGCTGCGGTGGCGTTTCTTGACTCCTTGGCGTCGACTCTTGTGGCAGCCACCGAGCGGTTGGTCCAGGATCTGGATGG GCAAAGTTGTGCGGCCCGGCCGGTGACGGCCGATGAGCTGACCGAGGTCGACAGCGCCGTGTTGGCTGACTTGGAACCGACATGGATTCGCCCCGGTTGGCGTCAC CTCAAGCATTTCAATGGTTAT :::::::::::::Rv171T7.seq::::::::::::: ATGCGTCACCCCGATGCGCCCAGATCGGGGCTTCGCAAATAAAGCACGAACAGGCGGGCAAAACGTCTATCTCGGAGCCGGAAGGGCAATCAGCCGACCGTCGACG (SEQ ID NO. 144) AACGACACCGGCGATAACCACTTAGGCGTTGAACGGCCGGCCCAAACATTACGCCTCCGTTGATAAGGCTTTCGGTCTCTTCCCCGGTCATCCCAAGCAGGTTGCG GCAAATTTGAACGCTTTCCTGTCCGGGCACCGGCCCCGGGCTTTGGGGTCCNTCCGA Clone Rv172 :::::::::::::Rv172SP6.seq::::::::::::: ATACTCAAGCTTCAATCGCGCCGCCACAATCCAAATATGCGTCTAGCGTCTCGATGAGCGTCGGTCCGGCATCGGCTAGGGGCCGCATCACGTCGGTATGCAGGGC (SEQ ID NO: 145) CACGATCGCCCAAGGCGTCGCCCATCAAGGGCGCGTTCGGGCAAAAATTCCCCTATCCAGCACGGGCCGCGGCGCTCCGCNCCAGCCGGCGACGGCGTTCATCCCG GAGATCGCCTCGCTAGCGCTGCGGTGCGCCGCGGTCAGCATGGGCGCCGTGGGGCCGATGACCACCGGGGCGT :::::::::::::Rv172T7.seq::::::::::::: TTCGGCGGGTCTGTAGATTGCGGTCGGCCACCCCACAGGCACTCATGAACCGCAGCCCACGATCGATCTCGGTGG (SEQ ID NO. 146) Clone Rv173 :::::::::::::Rv173SP6.seq::::::::::::: GCGCACCATCGCCAGTAGGTGCCCGTGGTCGGGCGCGTCGAGCCACCCGAGCGGAAACGCGAGTCCGAACAGCAACAGCAGGACGGGCGCAACCAGGGCGGTGACC (SEQ ID NO. 147) ATGCCCCCGGCGCTGAACATCAACCACAGGAAGGGCTCCGCCGAGCGTCCGCGCGACC :::::::::::::Rv173T7.seq::::::::::::: CATCGTCGAACTTCGGTCCGGGTTGNTAGNACCGCAGCACCAAACGCACCCACCGACCCCCACGCTTCACGCCAACCCTTTAGTTCATTGGCGTGAACAGCAGCGT (SEQ ID NO. 148) AGCCGGTTGCCCCGATATATGTGGAAAAATCGTTCGGACGTACAAAAAAAGTTCCTGACGCTGGCGTCAACTCGAAACTGCCTCGGAAGTCAATGATGATCCATCA GTCAATATTAAAGTCG Clone Rv174 :::::::::::::Rv174SP6.seq::::::::::::: ATACTCAAGCTTGTCTGCTGCCTCAGCGTATGCATCCAACAGCGCATCGCGATCAACGATCAGGCGCGCCGATTTCGGGCCGCGGGCAGTGGCACTGGCCAGATGG (SEQ ID NO. 149) CCGTTTTTTTCGAGAAACTTCAACGCCTGAGCGCTGCTTCCCATCGAGAGACCGGTGGCCTCTACAACCGATGCGACAGTTGGACCGGCGATGTTCGCCAGCAGCG CTTCACATACGGCAAGTNTGGCGCGG :::::::::::::Rv174T7.seq::::::::::::: TTGTCCAGGCGGGGAATCGGGCAGGGAGACGACACCTTCGTTCGGTTCGATCGTCGCGAACGGGTAGTTGGCCGCGACCACGTTGTTTCGGGTCAGCGCGTTGAAA (SEQ ID NO. 150) AGTGTCGACTTGCCGACGTTGGGCAGGCCCACGATCCCCAGGCTCAAGCTCACAGA Clone Rv175 :::::::::::::Rv175SP6.seq::::::::::::: ATACTCATGCTTGGCGCCTGGGTGGCAGCCCACCTGCCCACCACACGGACCGCGGTGCGGACGCGGCTGACGCGCCTGGTGGTCAGCATCGTGGCCGGTCTGCTGT (SEQ ID NO. 151) TGTATGCCAACTTCCCGCCGCGCAACTGCTGGTGGGCGGCGGTGGTTGCGCTCGCATTGCTGGCCTGGGTGCTGACCCNCCGCNCNACAACACCGGTGGGTGGGCT GGGCTACGGCCTGCTATTCGGCCTGGTGTTCTACGTCTCGTTGTTGCCGTGGATCGGCGAGCTGGTGGGCCCCGGGCCCTGGTTGGCACTGGCGACGACGTNCGCG CTGTTCCCCGGCATCTTCGGTCTGTTCGCCGTCGTGGTACCCTGTTGCCGGGTTGGCCC :::::::::::::Rv175T7.seq::::::::::::: CGCCAATTCACGATATCGTTAACCGATATCCCGAGCCGATAGCTGGCGGGCTCGGGTGGTGGCCAGCGGCGCTGCGACGAAAGGTGTGACCGTCATGAAACAGACA (SEQ ID NO. 152) CCACCGGCGGCCGTCGGCCGTCGTCACCTGCTCGAGATCTCAGCATCCGCAGCCGGTGTGATCGCGCTTTCGGCGTGTAGTGGGTCGCCGCCCGACCCCGGCAAAG GCCGGCCCGACACAACCCCGGAACAGGAAGTCCCGGTCACCGCGCCCGAAGNACTTGATGCGCGAACNCGGAGTGCTCCAAACGCATCCTGCTGAT Clone Rv176 :::::::::::::Rv176SP6.seq::::::::::::: ATACTCAAGCTTGGGCACTGACTTCGGTACCCCCTCCGCCTTTGGCCAGCAGCAGCCACAGCGCGGTTCGCGGACCGAACGTGGACATCAATAGCCCGGAATCGGT (SEQ ID NO. 153) GTGTGCAAGTTGGTAAACGGTGTTGATCCCAAGCTTTGCCAGCCTTTTCGTAGTCTTGGGCCCCACACCCCACAGTGCTTCGACGGTACGGTCACCCATGATGGCC ATCCAGTTGGCATCGGTGAGCTGATAAATGCCAGCTGGTTTCGCCAACCCGGTAGCGATCTTGGCGCGCTGCTTGTTGTCACTGATACCTATCGAGCAAGACAGCC CGGTTTGCGACAAAATGACTTTTCGGATCTCTTCGGCGACTTCGATGGGGTCGTCGGGA :::::::::::::Rv176T7.seq::::::::::::: AAAGTCCTGTGCCGGTTCGCTAAACACCCGGCGGACACTCAGACGGTGCTGGTGGTGCGGCATGGCACCGCGGGCACCAAAGCGCACTTCTCCGGGGGACGACAGC (SEQ ID NO. 154) AAGCGACCGCTAGACAAGAGGGGTCGTGCGCAGGCAGAAACGTTGGTACACAGCTGCTGGCGTTCGGCGCCACCGATGTTTATGCCGCCGACCGGGTGCGCTGCCA CCAGACGATGGAGCCACTCGCCGCGGAACTGAACGTGACCATACACA Clone Rv177 :::::::::::::Rv177SP6.seq::::::::::::: ATACTCAAGCTTGGGTTCCACGCCCGCGCAGCCACGCCGTCACCTTTCCACGAGACCTCACCTGCCGATCCGAAATGGAATCGGCCGTGACGGAATTGGCGCACCG (SEQ ID NO. 155) AACACCCAACGAGGTGGTGGCTTCGTCGCGAACCGTCACCCGAGTCGCGGCCACCGTGCGCACGGCGACGTTCTACACCCGCACCAAGATCCGAAAGCTGCAAGCT CCCAGCACCGATCCCGACGTCATCACCGCTGCCGCCCGGCACGTCCTTGACCTATTCGAGCTGGATCGGCCCGTCCGGTTGCTGGGAGTGCGGTTAGAACTGGCCT AGAACCGGCGGGCACACCGCNCCTCCCGCCCCGCAATTCTTGACCGCNCCGGCC :::::::::::::Rv177T7.seq::::::::::::: CGCGGTTGGCGTAGTTGGACGGGTCGCCCTCCGAGGCCAATGATGACGATGACCACGCCGATCACGATGGCCACCGAGAGGGACAACAACAGAAAGCTGACGAATC (SEQ ID NO. 156) CCTCCTTGGCGGCCGGGGCTTTGTGGTCGCCGGTCGCGATGGGCGCGAATTTACGGCCCGCTCCCCCAGGCCGCCGCGAAGCAGGGTCCCCAGCCAGTTGGCGTAG GCGGAATTAACGATCAGCGCCACCGCGATAACCTGCCATGCCTCGGGCATATCGATGTGCGGCCAGAACAGGCCGAAC Clone Rv178 :::::::::::::Rv178SP6.seq::::::::::::: CCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCAGCGACCACATTCAGCAGATGGA (SEQ ID NO. 157) CAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCGACATCGTCACCGCCGCACCACTGCCCGGCCTCGGGTTCACGCAG CCGTTGCCGCCCGCAGCGGACGATCACATCGCCGCGATCGCCCTGTTCGGGAATCCCTCGGGCCGCGCTGGCGGGCTGATGAGCGCCCTGACCCCTCAATTCGGGT CCAAGACCATCANCCTCTGCAACAACGGCGACCCGATTTGTTCNGACGGCAACCGGTGGCGAGCGCACCTAGGCTACGTGCCCGGGATGACCAACCAGGCGGCGCG TTTCGTCGCGAGCAGGATCTAACCGCGAGCCGCCCATAGATTCCCG :::::::::::::Rv178T7.seq::::::::::::: TAANACCCGTGTAATTTGGGATGGGCAAAAAGGCCAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGA (SEQ ID NO. 158) ACGTACGGCGTTTCAACACGTCGCGTCNCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCNCCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCG GGTAGTCGCCGCCCGGGCGGCTACAGTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCGACGCAACGGTTCCTACACGGCGATATGTTCGCCTCGCTG CGCCGGTGGACCGGTGGGTCTATCCCGGAGACCGACNTCCCGATCGAAGCGACCGTCTCCTCGATGGACGCCGGCGGCGTCACCCTGGGTTTGCTCACCGCCTGGC GTGGCCCCAA Clone Rv179 :::::::::::::Rv179SP6.seq::::::::::::: GTCCGCAAAAGACTCAGCGGCCGACTTTGCTCGCAGCTGGCGGTACCGCGCCACCGATTCGATGCCGTGGTCGCGGAAGAATGCCTCCCGAAATCGCACGGCCGAC (SEQ ID NO. 159) TCCAGTTCGGCGAGCATCCGCGATGCCACGTGCGGCTGCGCCCTGCCGGCCACGGCACCCACATGCGGCAGTTCGTCCACCTGGGCCAGCGCCCCGCCGCCGAAGT CCAAACAATAGAACTGCACCCGGCCCGCATCGTGGGTAGCAGCCAACGCCATGATCAGCGTCCGCAGCGCGGTTGACTTGCCCGTTTGCGGTGCACCTACGACCGC GACATTGCCTGCGGCCCCGGACAAGTCGATCGTCAGCGGCACCCN :::::::::::::Rv179T7.seq::::::::::::: CGTGGCCACGAACGCCGGGAGGGACANTCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAACGTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAA (SEQ ID NO. 160) CATTCGGGGATGGCAGCAACCTGGCAGCTACCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGGTAGTCGCCGCCCGGGCGGCTACAGTCTGAAACGCGATGACC ATCGATGTGTGGATGCATCATCCGACGCAACGGTTCCTACACGGCGATATGTTCNCCTCGCTGCGCCGGTGGACCGGTGGGTCTATCCC Clone Rv17 :::::::::::::Rv17SP6.seq::::::::::::: ATACTCAAGCTTTGCGGCGGGCGCCGAAATGTGAACGCACCAAACCCGCCCGCTGCGGGTCGGCGGGCCACTCGACCTCGAATTTCGCCGCCGTGACCATCCAGCC (SEQ ID NO. 161) CGACGGCAGTTGGGCACCCGGCCCCCCGGTCGCGGCATAACTGTTGGCGTCGCCGTCATAAAGCTCGAACAGCACCGAAACCGACTCCACCACCGGCCGGTGCGCC TCAAAATCCACGCCGATCTCCACATACCGGGAAAACGTCGGTGTCCCATCGGGTTTCGGCTTGCCCGCCAGCTGCACACCACCGGTGGCCTCGGCCACCTTCGCGG CCTGAGCGCAGCTACNCATCCTGACGATCATCACCCCGCCCCCGGCTCACGCTTGGCCTCCGTGACCGCACGCATCGCCCGGTTGCGCGCACCGCGACGCCCGTAC AGCCGCGCGCAC :::::::::::::Rv17T7.seq::::::::::::: AGCTTGCCGGGACTGCGGAACAGAAGCGGCGGTTCCTACCGCGGTGTGCGGCCGGCGCGATATCGGCCTTTTTACTAACCGAACCCGATGTGGGCTCCGATCCGGC (SEQ ID NO. 162) GCGCATGGCATCGACGGCGACGCCGATCGATGACGGCCAGGCTTACGAGCTTGAGGGTGTGAAGTTGTGGACCACCAACGGTGTGGTAGCGGACCTGCTAGTGGTT ATGGCGCGGGTACCGCGCAGTGAAGGGCACCGAGGGGGAATCAGCGCCTTTGTCGTCGAGGCTGATTCGCCCGGGATCACCGTGGAGCGGCGCAACAAGTTCATGG GACTGCGTGGCATCNAAAACGGCGTGACCCGGCTTCATCGCGTCNGGGTGCCCAAAGACAACTTGATCGGCA Clone Rv180 :::::::::::::Rv180SP6.seq::::::::::::: CTCAAGCTTGGCGATGCGGGCTGGCCAAAACTGGCCGGGCGGGGGTTGGCTTGTTCAATCAAGGGTGGGTTGCCG (SEQ ID NO. 163) :::::::::::::Rv180T7.seq::::::::::::: CCGAAGGCCCGTTCCCGGGCGTTCAGCAAGCGATCGTCGGTTGGCCCACTGCGGGTCGAATCTTGCGGCCGCGCCGGTCGTGGAACGCCCAGGTCACCCGGCGGCG (SEQ ID NO. 164) TACC Clone Rv181 :::::::::::::Rv181SP6.seq::::::::::::: ATACTCAAGCTTTTTTCTGCTCATGAAGGTTAGATGCCTGCTGCTTAAGTAATTCCTCTTTATCTGTAAAGGCTTTTTGAAGTGCATCACCTGACCGGGCAAATAG (SEQ ID NO. 165) TTCACCGGGGTGAGAAAAAAGAGCAACAACTGATTTAGGCAATTTGGCGGTGTTGATACAGCGGGTAATAATCTTACGTGAAATATTTTCCGCATCAGCCAGCGCA GAAATATTTCCAGCAAATTCATTCTGCAATCGGCTTGCATAACGCTGACCACGTTCATAAGCACTTGTTGGGCGATAATCGTTACCCAATCTGGATAATGCAGCCA TCTGCTCATCATCCAGCTCGCCAACCAGAACACGATAATCACTTTCGGTAAGTGCAGCAGCTTTACGACGGCGACTCCCATCGGCAATTTCTATGACACCAGATAC TCTTCGACCGAACGCCGGTGTCTGTTGACCA Clone Rv182 :::::::::::::Rv182SP6.seq::::::::::::: CTCAAGCTTGGTGCCGACATGGCCGGGCTGGAGCCCGCGTATGGCAAGGTTCCGCTCAATGTGGTTGTGATGCAGCAGGACTACGTTCGCCTCAATCAGCTCAAAC (SEQ ID NO. 166) GTCACCCCCGTGGCGTGCTGCGCAGCATGAAGGTCGGCGCCCGCACGATGTGGGCGAAGGCAACAGGTAAAAACCTGGTCGGCATGGGTCGAGCCCTCATTGGGCC GTTGCGGATCGGGTTGCACCGCGCCGGAGTGCCGGTCGAACTCAACACCGCCTTCACCGATCTTTTCGTCAAAATGGCGTCGTGTCCGGGGTATAC :::::::::::::Rv182T7.seq::::::::::::: CCGAAGCGTGGGAAATCCTGACCGAATACCGCGACGTGCTGGACACTTTGGCCGGCGAGCTGCTGGAAAAGGAGACCCTGCACCGACCCGAGCTGGAAAGCATCTT (SEQ ID NO. 167) CGCTGACGTCTAAAAGCGGCCGCGGCTCACCATGTTCGACGACTTCGGTGGCCGGATCCCGTCGGACAAACCGCCCATCAAGACACCCGGGGGAGATCGCGATCGA AACGCGGCGAAACTTGGGCC :::::::::::::Rv183SP6.seq::::::::::::: CGACTCGACAAGCATTCTTGACAGTTGTTTTGGCTCGGCATGGTTAGCCAAGGTTCTGCGGTCCCACCAGATCATCTTGGTCCGGTAGCGCTCGTCCGGGTATGCT (SEQ ID NO. 168) GCCGCCGGGATTCTCGCTGCTATTACTCCCCCCGAAAAACGCCACCGGTCCAGCGCGTGGGCCGCCGCGGTCCCCATCACAAACTGAACCCCCAACAGGGGACATG CTTAGCGGTAGGGCGCGCGCCAAGGCGGCAGCAATCGCATCACTGCGCTGCGCGTCACTATTAACCCACCCGGACTTCACTTCCACGACCCCGAATGGCGCCCGGT CATTGATCATCTTGCGCACCGCGGATAATCCGGGATTGCCAGCCCATTCGACTACCGCATGCGAGTCATCGGCTGACCGCAGCGGTCCGATTACCCGAGCGCCCCG ANTACATCTCCTCCAATATCAATGGGCGCAA Clone Rv183 :::::::::::::Rv183::::::::::::: GCGGTNTAGCTTCCCGTCGTACCGGCGACCGCCAGCCGAGAAGCTCGTTTTCCCAGTGTTGCTGGGGATTCTCACGCTGCTGCTGAGTGCGTGCCAGACCGCTTCC (SEQ ID NO. 169) GCTTCGGGTTACAACGAGCCGCGGGGCTACGATCGTGCGACGCTGAAGTTGGTGTTCTCCATGGACTTGGGGATGTGCCTGAACCGGTTCACCTACGACTCCAAGC TGGCGCCGTCTCGTCCGCAGGTCGTTGCTTGCGATAGCCGGGAGGCCCGGATCCGCAATGACGGATTCCATGCCAACGCTCCGAGTTGCATGCGGATCGACTACGA ATTGATCACCCAGAACCATCGGGCGTATTACTGCCTGAAGTACCTGGTGCGGGTCGGATACTGCTATCCGGCGGTGACGACCCCCGGCAAGCCGCCATCCGTGCTG CTGT Clone Rv184 :::::::::::::Rv184SP6.seq::::::::::::: CTCAAGCTTGGGCGTGACGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCG (SEQ ID NO. 170) CTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCA ATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAAAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAA CCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGGCGACCCGGCCTATGGTTATTCC :::::::::::::Rv184T7.seq::::::::::::: CGGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGAGGAGTGCTGAACCGTAGTCGAAGTGGGCGGCGTCAGACTCCA (SEQ ID NO. 171) CCCAGCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGTTTGGGGCAATGACAGGTGGCGGCGGTGCGTTCGGGTC GGCCGGCGGAGGTGCTGCGTTGGGATCGCCCGGCTGGGCATTCGGCGTGTTGGCGGCGGCCGGTGGTGGGGGGGCAACANGTGTCGCCGGTGCGGGTGGCGCTGCA Clone Rv185 :::::::::::::Rv185SP6.seq::::::::::::: NCTTGATATTGGCGTCAACGGTGTCGGCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCTCGTGGCCACGCATGTACAG (SEQ ID NO. 172) CACCACGCCGCGCCCCTCACGGGCGACCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGCGTGACCCAAACACATCGCCGGTCAAGCACTCCGAA TGCACCCGGACCAGCACGTCGTCACCGTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAGCGCGACATGTTCCACGTCCTCGTAGATGCTGGTGTAGCCGATGG CGCGAAACTCCCCATGACGAGTCGGAATCCGCGCCTCGGCGACCCGCTCAATGTGCTTCTCGTGCTTGCGCCGCCATTCGATCAAGTCAGCAATGGTGATCAGCGC CAGACCGTGCTCNTCGGCG :::::::::::::Rv185T7.seq::::::::::::: CATAAGGGCCGGCGTACCCGGTACCGGCCGCGGGCCTACCACGTGCCGGAACTGGAAGCGCAGTAAGCCCTCAACGCGCCACCGCTTTGGCCCGCGCGCCCGGCGT (SEQ ID NO. 173) AGGCGCATCGGCGGTGGCCGTGGGGCGGCGCACTGCGACCTCACCAGCGGCTTTCGAGCTTTGTTCGATCAACCGGCCAGCATGGTCGAGGATGCATTCGAGACCA TATTCGAAATTGGTTTCATCGGGGGCCCCGATCCGATGCCCCCTCCCAGTTGCGTGAGCAAGCAGCGGAGTCGTCGCGGGATCGATGGCCACGGGGTGTTCAATGG CGGATGGTCCGCTGCCCGCCGACTGGCTCTTGCGGGAGAGCCGATCTAGCACCACCGATCCGCGCACGTGGACCGAAACCGCCGAGTAGATGTCGAAAGCGT Clone Rv186 :::::::::::::Rv186SP6.seq::::::::::::: CGTCCTTTTCCCCAAGATAGAAAGGCAGGAGAGTGTCTTCTGCATGAATATGAAGATCTGGTACCCATCCGTGATACATTGAGGCTGTTCCCTGGGGGTCGTTACC (SEQ ID NO. 174) TTCCACNAGCAAAACACGTAGCCCCTTCAGAGCCNNATCCTGAGCAANATGAACAGAAACTGAGGTTTTGTAAACGCCACCTTTATGGGCAGCAACCCCGATCACC GGTGGAAATACGTCTTCAGCACGTCGCAATCGCGTACCAAACACATCACGCATATGATTAATTTGTTCAATTGTATAACCAACACGTTGCTCAACCCGTCCTCGAA TTTCCATATCCGGGTGCG Clone Rv187 :::::::::::::Rv187SP6.seq::::::::::::: CTCAAGCTTCATGTCCGTACGGCTCGGGTACGCTTCCGTCGCAGTGTGCGAGTGATAAATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTC (SEQ ID NO. 175) AGTTGCTCACCGGAATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTC CGCAGGCTTCGTCGGGGTGGTCGCGACACGCATGGGCCCCATCGCATTCAC :::::::::::::rV187T7.seq::::::::::::: NCGCCGCCAGCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGATGGCACGCCACCGCGACACCACCCGGCTGCGCTACGTCGA (SEQ ID NO. 176) GCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCGAGGTCGATACCGATTTGCGCATCCGCAGCCGCACCCTGGACGAC AGAACCGTGCCCTACGANTGCTTGTCGGGCGGGGCCAAAGAACAGCTTGGCATCCTGGCGCGATTGGCCGGCGCGGCGCTGGTCTCCAAAGAAGACGCCCTTCCGG TGCTGAT Clone Rv188 :::::::::::::Rv188SP6.seq::::::::::::: CGCCACGTTCATGGGCAACAACCCCGATCACCGGTGGAAATACGTCTTCAGCACGTCGCAATCGCGTACCAAACACATCACGCATATGATTAATTCGTCCAATTGT (SEQ ID NO. 177) ATAACCAACACGTTGCTCAACCCGTCCTCGAATTTCCATATCCGGGTGCGGTAGTCGCCCTGCTTTCTCGGCATCTCTGATAGCCTGAGAAGAAACCCCAACTAAA TCCGCTCGTTCNCCTATTCTCCAGCGCCGGG Clone Rv189 :::::::::::::Rv18SP6.seq::::::::::::: ATACTCAAGCTTCAACCGATTGACGCATTGTGCGAACTGACGGCGCCCGCGCATGGCCAATCCGGAAGACCATCATTGGCCAGTGGCCGGGCGCTAACAGGTTCCA (SEQ ID NO. 178) GCCCCCCACCAGTGCCGCTCGAACATGCGGTGCAACCCATTCGCAGGCCGGCAGGGAAAGCACCGCGGAAGCCGCAAAGGGCTGCAGTTCCGCGCCCAATAGTGTC GTCCGCAACCAGATGCGCTCGAAAACCGCGCCGGCAGTCAGCGCACCCGACGCGAGGTCGAGAGACGTCGTCAGCGCGCCCACATGGGGTGCCAATCGGCACGGCA GGTAGGCCGCGCGCAACCCGAACGCGTGGTGCATGCCCACGGTCCGCAGGAGGCGCAGCACCCGCCAATGCCGAAGCCCACGAAACATCGGGCGCATCCACGCTTC AACCTC Clone Rv18 :::::::::::::Rv18T7.seq::::::::::::: AGCTTTTGGCAGGGTCTCCTTCGAATTCGGCGTGCACCGCTATGGGTTGCAGCAGCGGCTGGCGCCGCACACCCCACTGGCCCGGGTGTTTTCGCCCCGAACCCGG (SEQ ID NO. 179) ATCATGGTGAGCGAAAAGGAGATTCGCCTGTTCGATGCTGGGATTCGCCACCGCGAGGCCATCGACCGATTACTCGCCACCGGGGTGCGAGAGGTGCCGCAGTCCC GCTCCGTCGACGTCTCCGACGATCCATCCGGCTTCCGCCGTCGGGTGGCGGTAGCCGTCGATGAAATCGCTGCCGGCCGCTACCACAAGGTGATTCTGTCCCGTTG TGTCGAAGTGCCTTTCGCGATCGACTTTCCGTTGACCTACCGGCTGGGGCGTCGGCACAACACCCCGGTGAGGTCGTTTTTGTTGCAGTTGGGCGGAATCCGTGCT CTGGGTTACAGCCCGAATCGTCAC Clone Rv190 :::::::::::::Rv190SP6.seq::::::::::::: ATACTCAAGCTTTGTCACACCAACTGTTTCCACCAGGCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCA (SEQ ID NO. 180) GCTCGCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCTGGCGCAGCTTGGGGATCGCGACTTCTATGGTTGCGGCACGGGTGTCGAAATCACGGTGGC GGTAGCCGTTGCGCTGATTGGACCGCTCATCGCTGCGTTCGCGGTAGCCCGCCGCGCACAGGGCGTCGGCTTCAGCCCCCATCAAGGCGGCGATGAACGTCGAGAG CAGCCCGCGCAGCAGATCCGGGCTCGCCTGTGCGAGTTGGTCAGCCAGAACCTGCTCGGTGT :::::::::::::Rv190T7.seq::::::::::::: CCTTAAGCCCCGCAGGGCCCGGCACGCGCGGTACCGCCCAGGTCGCCCAACAGATCGTCGATGTTCGCGTCGTCCGCCTCGCGCACGTGGTCTGTCACCAGTCAAC (SEQ ID NO. 181) GTTAACGCCGCCGCACATGTCCTGCGGCCGGGCAAAAACGTGAAAAACGAGCGGGCGACTGCAATGTCATGACACCGACGGCCGCCGATGGGCCCAGGGTCTGGCA GATTCGATCTGTGCGGCCAGTGCCAGCAGCGTCGCCTCGTCATACGGCCGGCCGACGAGTTGAACCGACATGGGCAGGCCGTCGCCGTCGAAGTCCCACGGCACCA CGGCCGCGGGCTGGCCGGTCAGATTCCAGACTTGAAAGTACGGAACCCGCTGCACCACCAGCAGCAACGTCGAAACTGCACCCCGGCGTTGGTAGGCGCCGATGCG GGACGGGCCGGTCGCGGCGCCTGGCGTCACAACTACGTCGACATCGTCGAAGATCGACTGGATCGGCTGCTCACACCACTCGGCGGCCGCAGGCCGCCATCCGCCG TC Clone Rv191 :::::::::::::Rv191SP6.seq::::::::::::: AGCTTTTTGAGCGTCGCGCGGGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGCCCACCCTCAT (SEQ ID NO. 182) TGGCGATGGCGCCGACGATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTGGGTGGTCAAGTCCGGTCTACGCTTGGGCCTTTGCGGACGGTC CCGACGCTGGTCGCGGTTGCGCCGCGAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCACCGCCGCGGCACTGCACGGCCAGTGCCGCGGCGATGTCAGCCATC GGGACATCATGCTCGCGTTCATACTCCTCGACCAGTCGGCGGAACAGCTCGATTCCCGGACCGCCCAGCGCATTGGTGATGGAATCGGCGAACTTGGCCACCCGCT GGGTGTTGACATCCTCGACGGTGGGCAATTGCCCCCGGTAACGTTTGCCGCCT :::::::::::::Rv191T7.seq::::::::::::: CGGTCCGACCCTGTTCGACGGCTACCTGAATCAACCCGATGCCACCGCCGCGGCGTTCGACGCCGACAGCTGGTACCGCACCGGCGACGTCGCGGTGGTCGACGGC (SEQ ID NO. 183) AGTGGGATGCACCGCATCGTGGGACGCGAGTCGGTCGACTTGATCAAGTCGGGTGGATACCGGGTCGGCGCCGGTGAAATTGAAACGGTGCTGCTCGGGCATCCGG ACGTGGCGGAGGCGGCAGTCGTCGGGGTGCCCGACGATGATCTAGGCCAGCGGATCGTTGCCTACGTAGTCGGCTCAGCGAATGTCGATGCGGACGGGCTTATCAA CTTTGTTGCCCAACAACTTTCGGTGCACAAGCGCCCGCGCGAGGTGCGTATCGTANATGCGCTGCCGCGCAACGCCTTGGGGAAAGTGCTCCAGAACATTGCTGTC AGAAGCTGANCTACGCGAATTATCGTGTTACGCTGGA Clone Rv192 :::::::::::::Rv192SP6.seq::::::::::::: ATACTCAAGCTTGCCGAAGTTCCGATGGGTCGCGCCGGCGAGCCCAGCGAAGTCGCTACCGTGGCCGTGTTCTTGGCTTCGGATCTATCCTCGTTCATGACCGGCA (SEQ ID NO. 184) CCGTGTTGGACGTGACTGGCGGCCGGTCCATATGACACCGAGATCATTGCCACGGTACGGCAATTCGTCAAGAAGGAAATCTTTGGGAATGCACCGGCCCTCGAAC GTGGCAACAGCTACCCGCAAGAAATCGTCGATCGGCTGGGTGTTATTGGCTTGCTCGGTCGCCGGCTGCAAGGGTATCGACACCACCGAGTTCATTCTCGGGCGTG CCGGCGCATTCGAGCTGGCGGTGCGCGCTGCCCAGCACCGTCATAGGTACTTGACGATGGTCCACGTCGGACGAGCGCCTCCACGTCGCTGCCGAACGGTATGCAT GGCGGCTACGATTCTC :::::::::::::Rv192T7.seq::::::::::::: CGGTGTCGGCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCTCGTGGCCACGCATGTACAGCACCACGCCGCGCCCCTC (SEQ ID NO. 185) ACGGGCGACCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGCGTGACCCAAACACATCGCCGGTCAAGCACTCCGAATGCACCCGGACCAGCACG TCGTCACCGTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAGCGCGACATGTTCCACGTCCTCGTAGATGCTGGTGTAGCCGATGGCGCGAAACTCCCCATGAC GAGTCGGAATCCGCGCCTCGGCGACCCGCTCAATGTGCTTCTCGTGCTTGCGCCGCCATTCGATCAAGTCAGCAATGGTGATCAGCGCCAGACCGTGCTCATCGGC GAACACCGCAATTCATCGGTGTTGCGCCATCGAGCCCTCATCTTTTTGGCTGACGATCTCGCAAATCGCCCCCGCGGGTTGCAGCCGGCAT Clone Rv193 :::::::::::::Rv193SP6.seq::::::::::::: ATACTCAAGCTTTGGGTGAAAGCCGATCACCGGAAGCCGCATGATCAGCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGC (SEQ ID NO. 186) GGGTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACGACGCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGT CAATCACGTTGTCGCTTTCTACGGTCACCGACCCGGTGACCGTNCTCGCCCGGTGCGCTCGGCCGATAAGTTGCACCGCCACCACCGCGACACCGTCTTGCACGCG GACCCACCCCCGGATCCGTTGTTGGCC :::::::::::::Rv193T7.seq::::::::::::: AGCTTGCTGGCATCCGCTCCAGTAGCGCCCCGCGCGTGGCTTCCAGCGCCCGCAGATGCTCCATGAGCCGGCCGGTCGAGTCGGCGCCGGCGTTCACCGCCACCCG (SEQ ID NO. 187) CCAGGAGCTGGCGGCCAGCATCTCCGCCTTCACGCATTGCGCGATCACAGAGAGAATATACGTCTCATATTCGTTGGAGGTCGTCGCAGGCAATCGGTCGATGACG GATTTGATGGCATCGAGCTGTGCTTCGGCGTAGCCCTCCAGCACGTCGGTATCGCTGTGGCGGTCCACGACGACCGCACCGGCGCGGCGGACAGCCGTCGGGTTGG ACGNTGTGCGGCGATCAGTCCGGCCAGCTCCGCCTCGGGATCAGCGGC Clone Rv194 :::::::::::::Rv194SP6.seq::::::::::::: ATACTCAAGCTTGCTGCAGCTTCCTATGACTGCTCCCGAAACCTGGGGGTGTGCCTGCTGTGTATGCACGGCATACGGACATCCTTCCCCTGAGACCCGCGGTCGA (SEQ ID NO. 188) ACCAGCCACGTGTCCATCATCAGGGGTCAACCCCGGCCAAGGGCGACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGACCAA AACAGCTGGTCGGCCGTTAGGAACTGAATTGAAACTCAACCGATTTGGTGCCGCCGTAGGTGTCCTGGCTGCGGGTGCGCTGGTGTTGTCCGCGTGTGGTAACNAC NACAATGTGACCGGGGGAGGTGCAACCACTGGCCAGGCGTCGGCGAAGGTCGATTGCGGGGGGAAGAAGAACTCAAAGCCAGTGGGTCGACGCGCAGGCCAACGC :::::::::::::Rv194T7.seq::::::::::::: AGCTTGACGCGGAGACGGACACATTGCGAACATTGATGACAAAATAGAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAAATTCCAAT (SEQ ID NO. 189) CAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCCGTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATATGGCGAAA AACGGTCGCCGTTGCACGACATTAAATGTCACGGTATTGTAGATTAAAAAGATACCCACCAACAAGGCAATCAAACTGAGAGCGGTTAAATTGACCGTAAAAGCGT CCGTCATCTGTTTGACGGTGTCCCGTTGGGTATCCGACGTTTCCATACGCACACCGGCCGGCAGTCTTTGTTGGATGCGTGTTGCAGTGGCCTCATCTTTGATGAT CAAATCGATGTGGCTCAGTCTTCCGGGCA Clone Rv195 :::::::::::::Rv195SP6.seq::::::::::::: ATACTCAAGCTTCGGCTCAGGCGGCGCTGCTGGTAAAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGC (SEQ ID NO. 190) GCAGGCTATCGCACCCGTTATCGGCTACGAGCAAATCGCGGTATCGCTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAG ATCGCCGTCAAGCATGTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCCGCT CGGATAGCGAGGTCAGCGAATTCNCNTGGCAGCTCCAAAGGGTCCTGCCGGTGCCGGTCTTTGCGCAAACNAAGGCNCAGGTTA :::::::::::::Rv195T7.seq::::::::::::: TGATCGCGCATCACCTGCTTCATAAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCA (SEQ ID NO. 191) GCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCG CGTTCTCCACCGACCGGGCCCGGGTGTGGGGTGTTTCGGCGACCGGCAGCCAGGTGGTCCACACTGCCGACGGGCGCCGCGAGCCGTTCACCGACCAGGCCGCCGA GCAAGTCCGCCCGATCGCATACTCCAACCGGTTGCGGTACTGCAGGTTCAGCTGGCGTACTCCTCGTCGCGCTCGGCGAGGTCTTGCTCCAGCACGTCGCANACGG CAG Clone Rv196 :::::::::::::Rv196SP6.seq::::::::::::: CAAAGCGCGAACTGCTCGCGGCAGCCCACGACGTGCTGCGTCGGATTGCCGGCGGCGAAATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCTGGCCCGCAA (SEQ ID NO. 192) CGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGCCCGGTCGGCAAGCCCGGCAGT TGCCAAACCCAGCGTGATCAGGCTCGGCTCGCGAGTTCCGGGAAGAAGTGGCTCCGCCTGATCACCTACCATCCGCCAGGATCTGCGTGTCTTCACCACGCCCGCC AAGGAGGTTGTTGTGGTGCTATCGACCGN :::::::::::::Rv196T7.seq::::::::::::: CCGGAAGCCGCATGATCAGCCAAGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTAATCGCCGACGGTGCCGGTTCGCGA (SEQ ID NO. 193) GCCGAAGGTGACGACGCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGTCAATCACGTTGTCGCTTTCTACGGTCACC GACCCGGTGACCGTNGTCGCCCGGTGCGCTCGGCCGAAAANTTGCACCGCCACCACCGCGAAACCGTCTTGCACNCCGGAAGCCACCCCCGATCCGTTGTTGGGCC AGGTTATTGGGT Clone Rv19 :::::::::::::Rv19SP6.seq::::::::::::: CCGGAACCGCCGACGGCACGGTATAACGCCTCCGCATATGGGTCGACAACCAGCGGGTCGGACTTCTGGGCTTCTAGCGTTCGCGCNGTCGCGACAAACAGCGCGG (SEQ ID NO. 194) TCGAACCGACACTCGTTGTGATGTCCTAGCTATCACGTTCGGTACGCACCCAATCGAGTCTAGCGCGGGTAGNTCAGCCCCGATCTCCANGCTCCGCCGAGCCAGG CGC :::::::::::::Rv19T7.seq::::::::::::: CTGGTTTATGTCCCGTTGAAGTTCCATCACCCGATGTGGCGGGAGCACTGCCAGGTCGATCTCAACTACCACATCCGGCCGTGGCGGTTGCGCGCCCCGGGGGGTC (SEQ ID NO. 195) GGCGCGAACTCGACGAGGCGGTCGGAGAAATCGCCAGCACCCCGCTGAACCGCGACCACCCGCTGTGGGAGATGTACTTCGTTGAGGGGCTTGCCAACCACCGGAT CGCGGTGGTTGCC Clone Rv1 :::::::::::::Rv1SP6D2.seq::::::::::::: CCGAGCAGTTGGGAATCGCTCTGCANCAAACCAATATTCTGCGCGACGTCGCGCGACGAGCTGGACCGATTAGGCGTACGCCTCCGNCTGGACGACACCGGGGCAC (SEQ ID NO. 196) TCGATGACCCCGACGCCTACGCTCGCAGGATATTGTTCGCCGGACCCCTCTCTAG :::::::::::::Rv1T7.seq::::::::::::: TATATAATACTCAAGCTTGCCGACGCCAACGCTCGCGCGATGTTGTTAGCCCGACCCGGCTCTTACATGGCACCGGTGCCCCACACGTCAGCCTGTGACGTCCTGC (SEQ ID NO. 197) ACCGCGACTCTTTACATAGAATGTGGATTGCCGGATTGGGGATGTCCGGCATCGCTCAATCTGTAGTCCGCGTTGTCCCGCGAGGGCCATGTGGATGGGGGGAAGG ATCCGTGGCGTCCGGGATCACCATGGGG Clone Rv201 :::::::::::::Rv201SP6.seq::::::::::::: ATACTCAAGCTTGCCGAAGTTCCGATGGGTCGCGCCGGCGAGCCCAACGAAATCGCTAGCGTGGCCGTGTTCTTGGCTTCGGATCTATCCTCGTACATGACCGGCA (SEQ ID NO. 198) CCGTGTTGGACGTGACTGGCGGCCGGTTCATATGACACCGAGATCATTGCCACGGTACGGAAATTCGTCCAGAAGGAAATCTTTCCCAATGCACCGGCCCTCGAAC GTGGCAACAGCTACCCGCAAGAAATCGTCAATCGGCTGGGTGTTATTGGCTTGCTCGGTCGCCGGCTGCGAGGGTTTCTACACCACCGAGTTCATTCTCGGGCGTG CCGGCGCATTCGAACTGGCGGTGCGCGCTG :::::::::::::Rv201T7.seq::::::::::::: GCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCTCGTGGCCACGCATGTACAGCACCACGCCGCGCCCCTCACGGGCGA (SEQ ID NO. 199) CCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGCGTGACCCAAACACATCGCCGGTCAAGCACTCCGAATGCACCCGGACCAGCACGTCTTCACC GTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAACGCGACATGTTCCACGTCCTCGTAGATGCTGGTGTAGCCGATGGCGCGAAACTCCCCANGACAAGTCGGA ATCCGCGCCTCGGCGAACCGCTCAATGTGCCTCTCGTGCTTGCGCCGCCATTC Clone Rv204 :::::::::::::Rv204SP6.seq::::::::::::: TGGTCCGTGTGCGCATACCAATACAACGCGCCGGGCACCTGACGCGGCGGCCGCAACCAATCGGTGGCCATCGCCATCTTCTGCTACCCGGTCAACGGACGCACCT (SEQ ID NO. 200) TCTCCTGGCCGACGTAGTGCGCCCACCCGCCGCCGTTGCGTCCCATCGATCCGGTCAAC Clone Rv205 :::::::::::::Rv205SP6.seq::::::::::::: GGCGTGTTGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTG (SEQ ID NO. 201) TGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGG TCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAAAGCCACTGGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCA ACCAAACTTGAAGGTGATTGTTTACCTGGGCTACGGCGACCCGGCCTATGGTTATTCGACCTCCCCGCCCAA :::::::::::::Rv205T7.seq::::::::::::: CGTCCGTGNCCCCTCAANCGCGTGNNGCCGAAGCGGCTGGTTACGACTCCCTGTTTGTGATGGACACTTCTACCAACTGCCCATGTTGGGGACGCCCGACCAGCCG (SEQ ID NO. 202) ATGCTGGAGGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGANCGGCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCGACCCTGCTGG CAAAGATCATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGAGCTGGAAACACCGCCAGCTCGGCTTCGAGTTCG GCACTTTCAGTGACCGGTTCAACCGGCTCGAAGAGGCGCTACAGATCCTCCAGCCAATGGTCAAGGGTGAGCGCCCAACGTTTTTCGGCGATTGGTACACCACCGA ATC Clone Rv207 :::::::::::::Rv207SP6.seq::::::::::::: CCGCTTCCGTGTAACCGAGCANNGCGAGCGANCTGGCGAGGAAGCAAAGAAGAACTGTTCTGTCAGATAGCTCTTACGCTCAGCGCAAGAAGAAATATCCACCGTG (SEQ ID NO. 203) GGAAAAACTCCAGGTAGAGGTACACACGCGGATAGCCAATTCAGAGTAATAAACTGTGATAATCAACCCTCATCAATGATGACGAACTATCCCCCGATATCAGGTC ACATGACGAAGGGAAAGAGAAGGAAATCAACTGTGACAAACTGCCCTCAAATTTGGCTTCCTTAAAAATTACAGTTCAAAAAGTATGAGAAAATCCATGCAGGCTG AAGGAAACAGCAAAACTGTGACAAATTACCCTCAGTAGGTCAGAACAAATGTGACGAACCNCCCTCAAATCTGTGACAGATAACCCTCAGACTATCCTGTCGTCAT GGAAGTGATATCGCGGAAGGAAAATACGATNTGAGTCGTCTGGCGGCCTTTCTTTTTCTCAATGTATGAGAGCG Clone Rv209 :::::::::::::Rv209SP6.seq::::::::::::: TGACACCCAACAGAGGGCACTTAAGATGGCAATGCGGCCGCCTACCTGCACGTTTTCGCGATGTCAGAGGATGCCGAGGGAGAACAATGCGAGCACGGCCGCTGAC (SEQ ID NO. 204) NTTGCTCACCGCTTTGGCGGCGGTGACATTGGTGGTGGTTGCGGGCTGCNAGGCCCGANTCNAGGCCGAAGCATATAGCGCGGCCGACCGCATTTCGTCTCGACCG CAAGCGCGACCTCAGCCGCAGCCGGTGGAGCTACTGCTGCGCGCCATCACGCC :::::::::::::Rv209T7.seq::::::::::::: ACGGGCGACGCTGAGGTGGGCCCGCGGCTATTCATGCTGTCGTCCACGTCCAGCGACGCACTGCGCCAGACGGCCCGCCAACTAGCCACCTGGGTGGAAGAACACC (SEQ ID NO. 205) AGGACTGCGTGGCGGCCTCGGATCTGGCCTACACGCTGGCGCGTGGCCGCGCGCACCGGCCGGTGCGCACCGCGGTGGTTGCCGCCAACCTGCCGGAGCTCGTCGA GGGTTTGCGCGAGGTGGCCGACGGTGACCCCTCTATGACGCGGCGGTGGGACACTGTGATCTAAGACCGGTCTGGGTCTTCTCCGGGCAAGGGTCTCAGTGGGCGG CGATGGGCACCCAATTGCTCGCCAGCGAACCAGTGTTCGCGGCCACCATCG Clone Rv20 :::::::::::::Rv20SP6.seq::::::::::::: ATACTCAAGCTTCGCGAGATCCGGATGGCACTCACGCTGGACAAGACCTTCACAAAATCTGAAATCCTGACCCGATACTTGAACCTGGTCTCGTTCGGCAATAACT (SEQ ID NO. 206) CGTTCGGCGTGCAGGACGCGGCGCAAACGTACTTCGGCATCAACGCGTCCGACCTGAATTGGCAGCAAGCGGCGCTGCTGGCCGGCATGGTGCAATCGACCAGCAC GCTCAACCCGTACACCAACCCCGACGGCGCGCTGGCCCGGCGGAACGTGGTCCTCGACACCATGATCNAAAACTTCCCGGGGAGGCGGAGGCGTTGCGTGCCGCCC AGGGCGAACCGCTGGGGGTTCTGCCGCAGCCCAATGATTGCCGCGCGGCTGCATCGCGGGCGGCGACCGCCATTCTTCTGCGAATACGTCCAGGAGTACTGTCTCG GGGC :::::::::::::Rv20T7.seq::::::::::::: AGCTTATGTGGCCGCCCACCTACCTTATCTAGCCTAGCTAACTAAATCCAGTGCCGACAGTGCGCGGCTGGCCACCCAGCATGAGGTTATGACCACGGCATATGCC (SEQ ID NO. 207) AGCGCGCTGGCGGCGATGCCGACGCTGACCGAGTTGGCCGCTAATCACACCAGCCATGCGGTGTTGCTGGGAACGAATTTCTTTGGAATCAATACGATCCCGATCG CGCTCAATGAGGCCGACTATGCGCGGATGTGGATTCAGGCGGCCACCACGATGAGTATCTATGAGGGCACCTCCGATGCGGCGCTGGCGTCNGCACCGCAAACCAC ACCGGCTCCGGTACTGTTCAACGGCGGTGCTGGCGTTTGCCAGCGCCTGCCGGCGATCTC Clone Rv214 :::::::::::::Rv214SP6.seq::::::::::::: ATACTCAAGCTTGCCACCCATGCCGAGCAAGGTCGACTCAGCGATGACGAATTGTTCTTCTTCGCGGTGTTGCTGCTGGTTGCGGGCTATGAGAGCACTGCTCATA (SEQ ID NO. 208) TGATTAGCACNTTGTTTCTGACGCTGGCCGACTATCCAGATCAGCTGACACTCCTTGCGCAGCAACCAGACCTGATCCCGTCGGCGATCGAGGAGCACCTCCGCTT TATATCGCAATCCAAAACATCTGCCGCACAACGCGCGTCGACTATTCGGTCGGTCAAGCGGTCATCCCGGGA :::::::::::::Rv214T7.seq::::::::::::: CCGGGGTAGAACGATGCGATCTGGGCCATGTCGACATCGGTGGTACAGGTAAACCGCGCCGTGTGCGCGGTCTCGGAGATCAGAACGTGGTCGCAGTTGACACCGC (SEQ ID NO. 209) GGGCTTTCAGCCAGTCGCGATAATCGGCGAAGTCGGCGCCTGCCGCCCCAACTAGCGCGACCTCGCCACCTAGCACACCGATGGCGAAGGCCATGTTTCCGGCCAC GCCGCCGCGGTGCATCATCAACTC Clone Rv215 :::::::::::::Rv215SP6.seq::::::::::::: ATACTCAAGCTTGGCGGCAACGCCACTACCGGGCTCACCAGGTCCTGTGCCGCCACCGCCGGCGCCGAAAGCACCATCAGGTCGTAGTTGTCTGGACGTTCGACAC (SEQ ID NO. 210) CGTAAGCGAACACAATGCCGCCGCCCATGCTGTGCCCGAGCACGATGCGCTTGCACCCGGGATATTCCCGGGTGGCGATCCCAACGAGGGTGTCGAAGTCAGCGGT GTATCTGAGATGTCTCTCACTATCATCCGTTTGGCACCCGAGCGGGCATGCCCGCGGGGGGTCAAC :::::::::::::Rv215T7.seq::::::::::::: GTCGACGGCATCAAGGTCCGCAGTGATGGTGTTCATCTCACCCAGGAAGGCGTGAAGTGGCTGATACCGTGGCTTGAGGATTCGGTGCGGGTCGCCAGTTAATCCG (SEQ ID NO. 211) CCGTGTGCTCCGGATGAGCGCGACGGTAACCCTGGAATTGTGCTGTGTGCTGGCTGTGTCGTTGTGATGAGCCTGTCTAAGTGGTGCGTAACCGTTTGACGAGCCG CGGCCTCGCTGCAAACATTGAAGCCCGCACGTCTGGGTTTGTATTTACACAACGAGGGCGCTCCCCGATCTGGCGCGCGCAACGAGGTGCNCACTATCCATTCGAG GTGAACTGGACTCCTTGATGCTCATGCCGGTGCGGTTTTGTC Clone Rv217 :::::::::::::Rv217SP6.seq::::::::::::: ATACTCAAGCTTGCGTTCGATGAAGTAGTCGTCGGTCAGCGCCGCCTCTTCGAGCTCCTTGGCGATGCCCAGCAAGGAGTCATCGCCGCCGAGCTTGGCCAGGATC (SEQ ID NO. 212) TTGTCGGCCTGTTCCTTGACGATGCGGGCCCGCGGATCGTAGTTCTTGTAGACACGATGACCGAAACCCATCAATTTGACCCCGGCCTCGCGGTTCTTGACCTTGC GTTACAAACTCGCTGACGTCGTCGCCGCTGTCGCGAATGCCCTC :::::::::::::Rv217T7.seq::::::::::::: NGTCAAGCCGAGCATGCGCGAGGNAACGACGAACCCAACAAGCCATGGTGGTTGGCGCCGTCGAGAGGTCGGCGGTCGCCACAACGGGAAGATCGCCTTGAGCGTC (SEQ ID NO. 213) GCTCGACCGCCGCCTCGAGTTGGGTCATAACGAAGTAGCTGATGCCGATCATGTCGACGTTTCCGTCGCATCAGCGTGCAGCGGCGACCCACTCGACGAGGTCTCG GTGCCGCCGCGGCCAGGGCACCAGCAGTGACGATTCCAGGCGCCGTCGGG Clone Rv218 :::::::::::::Rv218SP6.seq::::::::::::: CGATAATCGCTTCCGGTAAGTGCAGCAGCTTTACGACGGCGACTCCCATCGGCAATTTCTATGACACCAGATACTCTTCGACCGAACGCCGGTGTCTGTTGACCAG (SEQ ID NO. 214) TCAGTAGAAAAGAAGGGATGAGATCTCCCCGTGCGTCCTCAGTAAGCAGCTCCTGGTCGCGTTCATTACCTGACCATACCCGAGAGGTCTTCTCAACACTATCACC CCGGAGCACTTCTAGAGTAAACTTCCCATCCCGACCACATATAGGCTAAGGTAATGGGCATTACCGCGAGCCATTACTCCTACGCGCGCAATTAACGAATCCACCA TCGGGGCCGCTGGTGTCN Clone Rv219 :::::::::::::Rv219SP6.seq::::::::::::: NAATACTCAAGCTTTCTCGTGATTACCACCCGTGTAATTTGGGATGGGCAAAAAGGCGAATCACCGCGTGGCCACAAACGCCGGGAGGGACAATCTCGGGCGGCTA (SEQ ID NO. 215) GGGCTTCTCGCGGGAAGGCCCGAACGTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTAGGGGATGGCAGCAACCTGGTATCACCCTGGCCGGG CAATGATCTGCAGCGTCGCCGCGGGTAGTGNCCGCCCGGGCGGCTAC :::::::::::::Rv219T7.seq::::::::::::: CCAACTAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCAGCGACCACATTCAGCAGATGGC (SEQ ID NO. 216) CAGCGCGTGCCGGGCCACGATGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCGACATCGTCACCGCCGCACCACTGCCCGGTCTCGGGTTCACGCAG CCGTTGCCGCCCGCAGCGGACGATCACATCGCCGCGATCGCCCTGTTCGGGAATCCCTCGGGGCCGCGCTGGCGGGCTGATGATCGCCCTGACCCCTCAATTCGGG TCCAAGA Clone Rv21 :::::::::::::Rv21SP6.seq::::::::::::: ATACTCAAGCTTGCTGCAGCTTCCTGTGACTGCTCCCGAAACCTGGGGGTGTGCCTGCTGTGTATGCACGGCATACGGACATCCTTCCCCTGAGACCCGCGGTCGA (SEQ ID NO. 217) ACCAGCCACGTGTCCATCATCAGGGGTCAACCCCGGCCAAGGGCGACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGAGCAA AACAGCTGGTCGGCCGTTAGGAACTGAATTGAAACTCAACCGATTTGGTGCCGCCCGTAAGTGTCCTGGCTGCCGGTGCGCTGGTGTT :::::::::::::Rv21T7.seq::::::::::::: AGCTTGCGCGGCGTGGCGATCGCGGTTCAAGGCGCGCTCTTCGAGCACAACGAGCGAAGACAGCTCGGCGACGGAGCCTTTATCGACATCCGTTCGGGCTGGCTGA (SEQ ID NO. 218) CCGGCGGCGAAGAACTGCTGGACGCGTTGTTGTCGACGGTGCCGTGGCGAGCCGAGCGCCGTCAGATGTACGACCGGGTGGTCGATGTGCCGCGGCTGGTGAGTTT TCACGACCTGACCATCGAAGATCCGCCGCATCCGCAGCTGGCGCGGATGCGCC Clone Rv220 :::::::::::::Rv220SP6.seq::::::::::::: AATACTCAAGCTTGCGCACGACCAGGACGTCGAGTGGCGCTTGCAGTGACTTGGCGACCTCAAAGGCCACCGGTACCCCGCCGCGCGGCAAGCCAAGGACNACNAC (SEQ ID NO. 219) GGCCTTGCCGGATAGCTGCGCCAGGCGTTGCGCCAACTGGCGTCCAGCGTCGCCACGATCGTCAAAGAGCTTCATCTGCCGAGTGTGTCGCCATCTCATGGCTCCA AATATGGAATTAGGTCCCTGGGCCGACTGACGACAGTCCCTCAGCGACCGGATTGCGCATCCCGCCTTGTACGCTGCTCCGCAAATCCCGGGCTTGCGTCCGCGGA AGCGAACTCGGCGGCGCTACGGTGGTGGCTCACTTCGGCCGTGC :::::::::::::Rv220T7.seq::::::::::::: GGTTGGTGCGGTCCACCTTCGCGGCGGCGGCGCGATATGCCTTGCTGGTCTTGCTCATTTGATATCCAATCTATGGGTCGTGGTTACTCAGCGGGCCGAAGCTGGC (SEQ ID NO. 220) CCTCCCACGGGTAGGGCCCTATTCGACGGTGATGCCCATCGACCGAGCGGTACCGGCGATGATCTTGGCCGCAGCGTCGACGTCGTTGGCGTTGAGGTCCGTCTTC TTGGTCTCGGCGATTTCGCGGACTTGATCCCAGGTGACTTTGGCGACCTTGGTCTTGTGCGGCTCCGCCGAACCCTTCGCCACACCAGCGGCCTTAAGCAGCAGCT TGGCGGCGGGCGGCGTCTTCAGCGTGAAAGTGAAGCTACGGTCTTCATAAACGGTGATCTCCACCGGGATGACGTTGCCGCGCTGGTTCTCCGTCGCGGCGTTGTA CGCCTTGCAGAACTCCATGATGTTGACCCGTGCTGACCGAACGCGGGGCCCACTGGCGGGGC Clone Rv221 :::::::::::::Rv221SP.seq::::::::::::: ATACTCAAGCTTTTCGACCCGCAAGCCGGCGGTGCCCCTCCTCGTTCCGCTGCCCGGTCTGCTCGATCGGTTCGGGGTCGCCGCGCTAGGCCCAATTGCCCGGCTC (SEQ ID NO. 221) CTCCTCGGGCCGTTCCACAACCCGCATCGTCGCCGGGCTAGGTTCAAGCCATGCCGGTAAACCCCAGGACGCCAGTGCTGATCGGCTATGGACAGGTCAACCACCG AGGCGACATCGACGCCNAAAATCAGTCCATCGAACCCGTCGACCTGATGGCCNCCGCGGCCCGGAAAGCCGCCGAGTCCACCGTGCTCGAAGCGGTGGATTCCATC CGTGTGGTGCACATGCTGTCGGCGCATTACCGGAATTCCCGGGCGTCTCCTCGGC :::::::::::::Rv221T7.seq::::::::::::: NCCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCAGCTCGGCCGCGA (SEQ ID NO. 222) CAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCGCGTTCTCCACCG ACCGGGGCCGGGTGTTGGGGTGTTCGGCAACGGCAACCAAGTTGGTCCACACTGCCGACGGGCGCCGCAAATCCGTTCACCGAACCAGGCCGCCNAAACAATTCCG CCCGATCCCATAT Clone Rv222 :::::::::::::Rv222SP6.seq::::::::::::: ATACTCAAGCTTGTCGGGATCAATCTCGAGGGCATCCACGCACGAAAAGTAAACTCTATCAAGCTTTTTGACGACACCCACGGACGCCCCATATATGTTCGGGTGG (SEQ ID NO. 223) GCAAGAACGGTCCCTACCTGGAACGTTTGGTGGCCGGCGACACCGGTGAGCCCACGCCGCAGCGGGCCAACCTCAGCGACTCGATTACCCCGGACGAACTGACTCT ACAGGTGGCCGAAGAGCTCTTTGCCACACCGCAACAGGGACGGACTTTGGGCTTGGACCCAGAAACCGGCCACGAAATCTTTGCCAGGGGAAGGCCGGTTTGGGCC TTATGTTACCTATATCCTGCCGGAACCTGCGGCTGATGCGGCCGCGGCCGCTCAGGGAN :::::::::::::Rv222T7.seq::::::::::::: AGCAGCTAGCCGCGCTCGCCGCGCTGGTCGGTGCGTGCATGCTCGCAGCCGGATGCACCAACGTGGTCGACGGGACCGCCGTGGCTGCCGACAAATCCGGACCACT (SEQ ID NO. 224) GCATCAGGATCCGATACCGGTTTCAGCGCTTGAAGGGCTGCTTCTCGACTTGAGCCAGATCAATGCCGCGCTGGGTGCGACATCGATGAAGGTGTGGTTCAACGCC AAGGCAATGTGGGACTGGAGCAAGAGCGTGGCCGACAAGAATTGCCTGGGCTATCGACGGTCCAGCACAGGAAAAGGTCTATGCCGGCACCGGGTGGACCGCTATG CGCGGCCAACGGCTGGATGACAGCATCGATGACTCCAAGAAACGCGACCACTACGCCATTCAAGCGGTCGTCGGCTTCCCGACCGCACATGATGCCGAAGAATTCT ACAGCTCCTCCG Clone Rv223 :::::::::::::Rv223IS1081N1400.seq::::::::::::: CGCGACTGGCTCCCCGGNCGGCTGCTCGGGTCCGCCGATAGAGACCGGGATGTCGCCCGACGACGGGCAGCCGGGTTGCGTGGGACGGGGCGGGGGTCGGGCAGCC (SEQ ID NO. 225) CAAGCAACGGGCTAGTCCCCGAATCCTACGGAGCCGTCACCTACGCCTACGTAATAGTAGCTATCAATAACAGTTGACATACGCAACGATCTGTGAGATCAATATT GCCTGACGCATGTCAAGACAGGCGTCAAGACAGGTGTCAATAATTCGCTCCGCTGGTGACGGTAACCGGTCGTGCGGGTGTGTGACGCCTAAGGAAGGAGTGTGGG TGGTGACGCTGAGAGTGGTTCCTGAGGGTTTGGCGGCCGCCAGTGCGGCGGTGGAGGCGTTGACCGCACGGCTGGCCGCCGCACACGCTGGCGCGGCGCCGGCGAT TACGGCGGTGGTGGCGCCCGCGGCGGATCCGGTGTCGTTGCAGAATGCGGTGGGGTTTAGCGCCTTAAGTAGCCAGCATGCCGCGATCGCCGGCGAAAGGGTCCAA GAACTGGGT :::::::::::::Rv223SP6.seq::::::::::::: ATACTCAAGCTTATTGAACCGCGGGTCGCAGGCAAAGTGGACCTCATAACGACTCGGGTCCAGCGACCGCGCCAACACGAACGGCCGGACGACGTGGGCCAGGGTC (SEQ ID NO. 226) GCGGCCTCCCCTACAAACAGGATCCGTTGCCTGCGAACGACAGGCTCCGGTGCGGCGTTGGGCGCCGTGCTCGTCCCAGCGTCCGGTCCCGGGTCGCCGGCGACGC TTGTTTCCTCCATACTCGCCCCCTAATCTCGAGGCAGCCCGTACCCGCAGGCAACCTCCCAAAAATGCAATCCCGCAAAATGCAATGCGTCNAGCTATTTCTCACA CCGACCGCTAGTTGCGGATCAGAAATCCGTTGGGCGCGGAAGTCCAGCCGAATTTGTTCTCCCGCTCCGCATCATGCTTGTAATCGTTTGGAAATTCATCCTCATA TGCCTCGATCGCTTCATAGGGTCCAGGCCCAAACCCGGGCAGGACTGGGTGGCCGTTGATGTTGGAATCCTCCACTACTAGGTATTCACCGGC :::::::::::::Rv223T7.seq::::::::::::: GTCTCGATCATGGCCAAAGAGCTCGACGAAGCCGTAGAGGCGTTTCGGACCCGCCCGCTCGATGCCGGCCCGTATACCTTCCTCGCCGCCGACGCCCTGGTGCTCA (SEQ ID NO. 227) AGGTGCGCGAGGCAGGCCGCGTCGTCGGGGTGCACACCTTGATCGCCACCGGCGTCAACGCCGAGGGCTACCGAGAGATCCTGGGCATCCAGGTCACCTCCGCCGA GGACGGGGCCGGCTGGCTGGCGTTCTTCCGCGACCTGGTCGCCCGCGGCCTGTCCGGGGTCGCGCTGGTCACCGGCGACGCCCACGCCGGCCTGGTGGCCGCGATC GGCGCCACCCTGCCCGCAGCGGCCTGGCAGCGCTGCAGAACCCACTACGCAGCCAATCTGATGGACGCCACCCCGAAGCCCTCCTGGCCGTGGGTGCGCACCCTGC TGCACTCCATCTACGACCAGCCCGACGCCGAATCAGTTGTTGCCAATATGATCGGGTTCTCGAC Clone Rv224 :::::::::::::Rv224SP6.seq::::::::::::: ATACTCAAGCTTTCGTCAGTTCATGGCGCCAGCAGACCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGG (SEQ ID NO. 228) CGCGAACGACGCCAGCGACCACATTCAGCAAATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCAAGATCTTC ACCGCCGCACCACTGCCCGGCCTCGGGTTCACGCATCCGTTTGGCCGCCGCC :::::::::::::Rv224T7.seq::::::::::::: GCCCCGTGTAATTTGGGATGGGCAAAAAGCGAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAACGT (SEQ ID NO. 229) ACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGGTA GTCTCCGCCCGGGCCGC Clone Rv225 :::::::::::::Rv225SP6.seq::::::::::::: ATACTCAAGCTTCCTTTGACCGAACGCGTCCACCGCACCGTGAGATTGGTGGCGCCATTCGTCGTGGTGTAGCTGCTGTTGGCGGCGTCGCCGTATTGTGCGGGCC (SEQ ID NO. 230) AGCCTTGTGCGGGGGCCGCTTCTACCCACAAGTCGGCACTTCCGCAACCGCCCAGCTCGACCGCGAATTACGGCGGCCGCAACGGCCGCCGGAAGGCGTCACGCAA TCGCTTATCCTTTCCAGGTTCCCAAATCCTCCGCTTACTTGGGTCCTTCATCGG :::::::::::::Rv225T7.seq::::::::::::: GGCAGCGGCGACAACCGGAACGTCCGCACGGTGCTCAATCACGGGTGCACGGTGTGCATCAGAATGGCGGGGGTTCGTTGTCGCGGTGAGGCGTTCGGCGAGGAGG (SEQ ID NO. 231) TAGTGTCTACCCCTTGCCCGCGGGTTCGTGCGGACTGAAAGGGATTTCATTGGGAACCCACGGCTGCGTATCGCAGGGCCTCGGTGACGTCTGCTTCCTCNAGCTC AGGAAGTTCGGCGAGAATCTCGGTGGATGTTATTTGGTCCGCCTAC Clone Rv226 :::::::::::::Rv226SP6.seq::::::::::::: ATACTCAAGCTTTCTCGGCTTCTCTGATAGCCTGAGAAGAAACCCCAAGTTAATCCGCTGCTTCACCTATTCTCCAGCGCCGGGTTATTTTCCTCGCTTCCGGGCT (SEQ ID NO. 232) GTCATCATTAAACTGTGCAATGGCGATAGCCTTCGTCATTTCATGACCAGCGTTTATGCACTGGTTAAGTGTTTCCATGAGTTTCATTCTGAACATCCTTTATTCA TTGTTTTGCGTT Clone Rv227 :::::::::::::Rv227SP6.seq::::::::::::: ATACTCAAGCTTGGTGACCGGCACCGCGATACGTTGCGGCAGGCATCTGGGCTGGCGGTGGTTCGCCGCTCCGAAGCCGTCGAACACCATCGCCAGCGCGGCTTCC (SEQ ID NO. 233) ACATCAACGACCATTTCGGCCAGCTTGCGGCGCATCAGCGGCTTGTCGATGAGCGCCCCACCGAATGCCCGCCGCTGCCCGGCGTATCACATCGATTCGACCATCG CGCGGCGCGCGTTGCCGAGGGCGAACGAGGCGGTGCCCAACCGCAATCTGTTTGGTCAGCTCCCTCATGCGGGTTGATTCCTTGCCGTCCGGACGGGCCCGCGTCA TGCGCTCGGTTCGCC :::::::::::::Rv227T7.seq::::::::::::: CCGTTGCGCAGCGTGAGCCGATAGTTGACATCCGGCTCGGTGAAGGTGAAATCGATGGCCAGGTCGAGGTCCCATGCGCGTGGGCCATTGATGCCGATCGCCAGGA (SEQ ID NO. 234) CGTCAAAGATTTGGTCCGGCGTCAGCTGGGCGAAAAACGTGGGCGCCGGGACTTGCCCGGAGCTGCCCGGGTTCCCGTCGCGCAGCTCGGCGGCCCCGGTCAGAAA GAAATTGCGCCAGGTCGCACACTCCGCGCCGTAGGCCAGCTGCTCCAGGGTGTCGGCATAGAGCCCGCGGGCCGCAGCGTGCTCGCTGTCGGCGAACACCGCATGG TCGAGAAGCGTTGCCGCCCAACGGGAAATCACCTGCGTCGAAAGCTTCGCGGGCCAGCTCCAGCACTCGGTCGATGCCACCCAACGCGT Clone Rv228 :::::::::::::Rv228SP6.seq::::::::::::: ATACTCAAGCTTGCGGATGTTACCCCTGACAGCGTGAACTATGTCNAAACACACGGCACCGGAACGGTGTTGGGGGACCCCATCGAGTTCGAGTCGCTGGCGGCCA (SEQ ID NO. 235) CTTATGGCCTGGGTAAAGGCCAGGGCGAGAGCCCGTGCGCATTGGGGTCGGTCAAAACCAACATCGGCCACCTGGAGGCGGCCGCCGGTGTGGCTGGATTCATCAA GGCGGTGCTGGCGGTGCAACGTGGGCACATTCCCCGCAACTTGCACTTCACCCGGTGGAACCCGGCCATCAACACGTCGGCGACGCGGCTGTTCGTGCCGACCGAA AGCGCCCCGTGGCCGGCGGCTGCCGGTCCACGCAGGGCTGCGGTGTCATCGTTCGGCCTCAGCGGGACCAA :::::::::::::Rv228T7.seq::::::::::::: CCGGTAACCAGATCAGCTCGTCGACCTCACTGCCGGGGGTGAATTCCCCACCGGTGCTGCGCGCTGCCCAGTAGTGCACCTTCTTGACGCCTCGAAAAGGGGAGTC (SEQ ID NO. 236) GGTCGGGTAGGTCACCGTCAGGAGCCGCCTACCCAGGTTGGCGCGGTGACCGGTCTCCTCGAGTATCTCCCGCACCGCCCCCACCGGTGCGGTCTCGCCCGGATCC ACTTTGCCCTTGGGCAGCGACCAGTCGTCGTAACGGGGGCGGTGAATGACAGCGATCTCGACCGGCCCTTCCGAATCGGCACTGCCGGGTCGCCAGAACACCGCAC CGGCGGCGTACACAATCCGGCCCGCCGAGCGCCGGCGGGCGGACGANTTCTGGATCGACACCTCAACTCCTGCAGGTCAATTCGGCCAAGCTGCTCGCGGTCGTGG ATGTGGTC Clone Rv229 :::::::::::::Rv229SP6.seq::::::::::::: ATACTCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCACCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGATGG (SEQ ID NO. 237) CACGCCACCGCGACACCACCCGGCTGCGCTACGTCGAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCGAGGTCTA TACCGATTTGCGCATCCGCAGCCGCACCCTGGTCGTCTCGTACCGTGCCCTACCTCTGCTTGTCGGGCGGGGCCA :::::::::::::Rv229T7.seq::::::::::::: TCCGTACGGCCCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGG (SEQ ID NO. 238) AATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGCAGGCTTCGTC GGGGTGGTCGCGACGCGCATGGGCCACCATCCATCCACCAGGTCTGCGCGAATCACCCGC Clone Rv22 :::::::::::::Rv22SP6.seq::::::::::::: GGACACATTGCGAACATTGATGACAAAATAGAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAAATTCCAATCAAGAGGCCCAAGCCC (SEQ ID NO. 239) GTACCAATCAGCCCGGCAACGAGGGATTCCGTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATATGGCGAAAAACGGTCGCCGTTGCA CGACATTAAATGTCACGGTATTGTAAATTAAAAAGATACCCACCAACAAGGCAATCAAACTGAGAGCGGTTAAATTGACCGTAAAAGCGTCCGTCATCTGTTTCAC GGTGTCCCGTTGGGTNTCCGACGTTTCCATACGCACACCGGCCGGCAGTCTTTGTTGGATGCGTGTTGCAGTGGCCTCATCTTTGATGATCA :::::::::::::Rv22T7.seq::::::::::::: GCCTGGCCCAGGTGAAGGCCGACCTCGACGCCAAAGCCGCTGATCCGGCACATGAGTCGGTGGACTGGGACTTGAAGTCGCTGCGATGGGCGTGGAACCGAGCCAA (SEQ ID NO. 240) AGATGACGTGGCGCCGTGGTGGGCCGAGAATTCCAAGGAGTGCTACTCGTCGGGGTTGGCCGATCTGGCCCAGGGCCTGGCTAATTGGAAAGCTGGCAAGAACGGG ACCCGCAAAGGCCGGCGGGTGGGCTTCCCGCGATTCAAATCCGGGCGGCGTGATCCTGGCAGGGTGCGGTTCACCACCGGCACCATGCGCATAGAGGATGACCGGC GCACGATCACGGTCCCGGTGATCGGGCCGCTGCGGGCCAAGGAGAACACCCGCCGGGTGCAACGCCACCTCGTGAGCGGGCGCGCGCAGATCCTGAACATGACCTT GTCGCAGCGGTGGGG Clone Rv230 :::::::::::::Rv230SP6.seq::::::::::::: TAACTCAAGCTTCAAGTCCGCNGTCCGACCCTGTTCGACGGCTACCTGAATCAACCCGATGCCCCGCCGCGGCGTTCGACCCGACAGCTGGTACCGCACCGGCGAC (SEQ ID NO. 241) GTCGCGGTGGTCGACGGCAGTGGGATGCACCGCATCGTGGGACGCGAGTCGGTCGACTTGATCAAGTCGGGTGGATACCGGGTCGGCGCCGGTGAAATTCAAACGG TGCTGCTCGGGCATCCGGACGTGGCGGANGCGGCAGTCGTCGGGGTGCTCGACTATTATCTAGGCCAGCGGATCGTTGCCTACGTAGTCGGCTCAGCGAATGTCGA TGCGGACGGGCTTATCAACTTTGTTGCCCAACAACTTT :::::::::::::Rv230T7.seq::::::::::::: CCATGTCGCCCAACATATCGTCGATGTTCGCGTCGTCCGCCTCGCGCACGTGGTCTGTCACCAGTCAACGTTAACGCCGCCGCACATGTCCTGCGGCCGGGCAAAA (SEQ ID NO. 242) ACGTGAAAAACGAGCGGGCGACTGCAATGTCATGACACCGACGCCGCCGATGGGCCCAGGGTCTGGCAGATTCGATCTGTGCGGCCAGTGCCAGCAGCGTCGCCTC GTCATACGGCCGGCCGACGAGTTGAACCGACATGGGCATGCCGTCGCCGTCGAAGTCCCACGGCACCACGGCCGCGGGCTGGCCGGTCAGATTCCANACTTGAAAG TACTGAAGCCGCTGCACCACCAG Clone Rv231 :::::::::::::Rv231SP6.seq::::::::::::: CGAAAGCGTGAAACAGCTCGCGGCAGCCCCCGACGTGCTGCGTCGGATAGCCGGCGGGCGAAGATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCTGGCCC (SEQ ID NO. 243) GCAACGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGCCCGGTCGGCAAGCCCGG CAGTTGCCAAACCCAGCGTGATCNTGCTCNGCTCTNTANTTCGGCGAAGAAGTGGCTCGCCTGATCACCTACCATCGGCCAGGATCTGCGTGTCATCACAACGCTC GCCAAGGAGGTTGTTGTG :::::::::::::Rv231T7.seq::::::::::::: TCCGCCACGCTTCGCGCCGCCCGGCATACGGCGCGTACCGATCTCCGCGTCATACACCGCGGGTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACGACGC (SEQ ID NO. 244) TGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGTCAATCACGTTGTCGCTTTCTACGGTCACCGACCCGGTGACCGTAGT CGCCCGGTGCGCTCGGCCGAGAAGCTGCACCGCCACCACCGCGACACCGTCTTGCACGCGGACCCACCCCGGATCGGTTGTTGGCCAAGGTAATTGGGTCATTCCA TTTGACGGGACGCCGACCC Clone Rv232 :::::::::::::Rv232SP6.seq::::::::::::: CATTCTTTAACAGTTGTTTTGGGCTCGGCATGGTTAGCCAACGTTCTGCGGTCCACCATATCATCTTGGTCCGGTAGCGCTCGTCCGGGGTATGCTGCCGCCGGGA (SEQ ID NO. 245) TTCTCGCTGCTATTACTCCCCCCGAAGAACCGCCACCGGTCCAGCGCGTGGGCCGNCGCGGTCCCATCACAAACTGAACCCCCAACAGGGACATGCTTATCGGTAG GGCGCGCGCCAAGGCGGCAGCAATCGCATCACTGCGCTCTGCGCGTCACTATTAACCCACCCGGACTTCACTTCCACCACCCCGAATGGCGCCCGGTCATTGATCA TCTGGCGCACCGCGGATAA :::::::::::::Rv232T7.seq::::::::::::: CGGTGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCATGCCGATGCCGCGGCCTCGTGGCCACGCATGTACAGCACCACGCCGCGCCCCTCACGGGCGAACATC (SEQ ID NO. 246) GCCAGCGCGGCGTCCAGCTGAAGCCCGCAATCGCAGCGGCGTGACCAAACACATCGCCGGTCAAGCACTCCGAATGCACCGGACCAGCACGTCGTCACCGTCGGCG TTGGGCCCGGCGATCTCGCCGCGGACCATGCGCGACATGTTCCACGTCCTCGTANATGCTGGTGTAGCCGATGGCGCGAAACTCCCCATGACGAGTCGGAATCCGC GCCTCGGCGACCCGCTCAATGTGCT Clone Rv233 :::::::::::::Rv233SP6.seq::::::::::::: CGGCATCTGGCGGCTGAACCTGTTCTTGGGCAACATGCCGAGGATCGCCTCTTCCACCACGCGGTCGGGGTGGCGTTGCATTACCTCACCGATGGTGCGCTTGTGC (SEQ ID NO. 247) AGGCCGCCGGGATACCCCGAGTGCCGGTAAACCATCTTGTGCTGCAGTTTGTCGCCGCTGATGGCGACCTTGTCGGCGTTGATCACGATNACNAATCACCGCCANC GACATTGGGGGCGAACGTCGGCTCGTGCTTGCCGCGCAGCAGGCTGGCCGCCGCGACGCAAGGCGCCAACCACCACGTCCGTGGCGTCGATGACGTACCACCATCG CGTGGTGTCACCCGCCTTGGGC :::::::::::::Rv233T7.seq::::::::::::: GCGGCAAAAATTGAAGCACTCNTGGCCACTNCCGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAACGTACTGCGTTTCAACACGTCG (SEQ ID NO. 248) CGTCGCCCTCCGACCGCGAACATTCTGGGATGGCAGCAACCTGTTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGGTAGTCGCCCCCGGGCGGCTAC AGTCTGAAACGCGATGACCATCGATGTGTGGACGCCGCATCCGACNCAACGGTTCCTACACTGTGATATGTTCGCCTCGCTGCGCCGGTGGACGGTGGGTCTATCC CGGA Clone Rv234 :::::::::::::Rv234SP6.seq::::::::::::: CGCGTTGAACTGAAGGGGTGCCGCCCGGCTCGAGCAGGCAAGCCATTTGTTCGATGCGGTTACCGAAGATCTCTTCGGTGACTGCCCGCCGCCGGCCAGCTCGGCT (SEQ ID NO. 249) CAGTGTCCGGCGTTGGTCGCCGCGGCGACAATCTTGGCGTCCACGGTGGTCGGGGTCATGCCCGCGAGCAGGATTGGCGAGCGGNCGGTCAGCCGGGTGAACTTCG TCAAGAGCTGACGCTGCGGTTGGGGAGGCGAATCATGGTCGGTGCGTAGCCTCGACTAGGCCCGGG :::::::::::::Rv234T7.seq::::::::::::: TGACAACGCGGCGGCGATTACCCCGCTACCGCAGCAGCATGACGCGGTAGCGAACACCGCCGGATGCAGCGCAGGTGCGTCGATGTGCTCACGGAATCGCCCCGGC (SEQ ID NO. 250) ACCGCGATCTCGAGGATCACCAGTGCCACCCCCTGCAGCGCGACACCGACGATTCCGTACACCGCCACGCCGATCAGGCCCTGGGCCACGTGATTGGAGCTGGCGT ATATGGCGGCGATGGTGACGATGGTCATCGCCTCTTACATTGTGGCGGCCAGAACCACGGCGTTGGGGCGGCGGTCGATGAACACTAGGCGACCANATCCCCGGGG TCAACAGGTTGACCATCC Clone Rv235 :::::::::::::Rv235SP6.seq::::::::::::: CGCGGACATCCCGAACGAGGACACGCGACCGCTTCGGTGTGTGATCTATCAGGGCTCGCACCACGCGCAACCGCTTCCGGCTACCTAGACGCGGT (SEQ ID NO. 251) :::::::::::::Rv235T7.seq::::::::::::: GCATGCGGGTGATGCCGTTCTCAGTGCGCAACAGCGTTCGACGCGGCATACCCAGCCGCACATGCCGTGCACGCCGGNGCCGGGGCGGGAATCT (SEQ ID NO. 252) Clone Rv237 :::::::::::::Rv237SP6.seq::::::::::::: CTCAAGCTTCAGNCCNTCTAAGCGGTCTGCGCGGCGATCGCAAAGATCGCCCTTTGCCGGCGTTGGGGGCTTCTGCTCGGGGGTGTTGTACACCTTCTCGAACACC (SEQ ID NO. 253) TCGGCACCGACACCACCACCGTCGGCTTGAACACCGCCAACATCGGCAGCANATCTTGATGTCCTGGTGAATCCACGGTGACTTTGGAGTGGAAGGCGGCCATACT GATCGCGCGCGCCACCACATGAGCTAGCGGCAGGAAAACCAGCAGCCGCTCACCCTTGCGCAGCAGCGTCGGGTGATATGCCTGGCGCCC :::::::::::::Rv237T7.seq::::::::::::: AGTCGAANGTCAGTCCGGTCTCCTCTCCGACTACGGCCAAGAACTGGGGCGACGGTGTCAGTGCAGAACAGCGGAAACTGGTGGCGCCCTAGGCGAGCGAACGCTC (SEQ ID NO. 254) ACAAACGGCGGTGACCGCTTCTGGTCGTGCACCATCGAGCCGTGCCCAGCCCGGCCGCGTGCCGTCAGCCGCATCCACTGGATGCCCTTCTCGGCGGTTTCAATCA NGTACAGGCGACGTTCGCCACCATCGTGCCGGGGCACGGTTAGCGAGAAACGCCGACTTCACCGATTGCCTCGGTGATGxxxxx Clone Rv23 :::::::::::::Rv23T7.seq::::::::::::: AGCTTCGCGGCGTGGCGATCGCGGTTCAAGGCGCGCTCTTCGAGCACAACGAGCGAAGACAGCTCGGCGACGGAGCCTTTATCGACATCCGTTCGGGCTGGCTGAC (SEQ ID NO. 255) CGGCGGCGAAGAACTGCTGGACGCGTTGTTGTCGACGGTGCCGTGGCGAGCCGAGCGCCGTCAGATGTNCGACCGGGTGGTCGATGTGCCGCGGCTGGTGAGTTTT CACGACCTGACCATCGAAGATCCGCCGCATCCGCAGCTGGCGCGGATGCGCCGGCGGCTCAACGACATCTACGGCGGCGAACTGGGTGAGCCCTTCACCACCGCCG GGCTGTGCTACTACCGCGACGGCTCTGACAGCGTCGCCTGGCATGGCGACACCATTGGTCGCGGCAGCACTGAGGACACTATGGTGGCGATCGTCAGCCTCGGCGC CACCCGCGTCTTCGCGCTGCGGCCGCGTGG Clone Rv240 :::::::::::::Rv240SP6.seq::::::::::::: AGCTTCAGCTGATACTCGACCAGCCCCACTCGGGCCAATACGTGAATGTCTAGCATCTTCACCCGTTCACGGGCTANTCGAGTAGTAGACATTGATTAGCCTGAAC (SEQ ID NO. 256) GTACCTCCGACGCCAGCTGACGAACGGGTATGACGGATGGATTTCGTGGTGTCGCGCCCGAGGTCAATTCGTTACGGATGTATCTCGGGGCCGGATCGGGGCCGAT GTTGGCGGCCGCGGCGGCCTGGGACGGACTATCCGACGAACTGGCGGTGGCGGCGTCGTGGTTTGGGTCGGTGACCTCGGGCCTGGCGGATGCGGCGTGGCGCGGC CCGCGGCGGTTGCGATGGCNCGCGCGGT :::::::::::::Rv240T7.seq::::::::::::: CTGGTCATGGACGTTGCTCCGGTAGTGGCTCACTGCCGATCCTCCTCGTTGAGAGTGCCACCTCAGGGTTGGGTAGGGTTGGGTACTCGAAACCAAGTTACCCACC (SEQ ID NO. 257) AGTAACACCGTCAAAATATATCCGTTGCATAGGTCAATGCAAGTTGATGTGAGCTACATTGCACCAACTAACTAACCAACCGGTTGGGTTAGCGGTGATCCTGGCC GTGTCGGTCCTCTCACCTGCGGTGATAGCGATCAAATGAAGAATATGCGGAGTCTAGGGCGGCAGCGCCTGGCANCGTAGATCATCGGCTCACGCGGATGCGGCCT CTTGGTACGGACATGCGCGCG Clone Rv241 :::::::::::::Rv241SP6.seq::::::::::::: CTCGTGAGTAGCACCCCTGTAATTTGGGATCGGCAAAAAGGCGAATCACCGCGTGGCCACGACACGCCGGGAGGGACNATCTCGGGCGGCTAGGGCTTCTCGCGGG (SEQ ID NO. 258) AAGGCCCGAACGTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGG :::::::::::::Rv241T7.seq::::::::::::: GGATCAACTACCGGCCAACGGTGATTCTTGGGCGCCGCTGACGCGCGAACGACCCAGCGACACATTCAGCAGATGGCCAGCGCGTGCCGGGCCACGATGTTGGTGC (SEQ ID NO. 259) TCGGCGGCTACTCCCATGGTGCGGCNCGTGATCGACATCGTCACCGCCGCACCACTGCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGACGATCACAT C Clone Rv243 :::::::::::::Rv243SP6.seq::::::::::::: AGGACCGTCAGCACGGCGACGTGCTACTCGCCGAGCAGTGGGAATCGCTCTGCAGCAAACCATTACTCTGCGCGACGTTCGAGATGACCTTCTGAATGGACGGATC (SEQ ID NO. 260) TACCTGCCGCGCGACGACCTGGACCGCGTATGCGTCCGCCTCCGCCTGGACGACACCGGGGCACTCTATGACCCCGACGGACGGCTCGCGGTACTGCTGCGGTTCA CCGCCGACGCCCGCACGGTACGCGTCGGGACTGCGCTGAGTCCANCCTCGACGCCGTAGCGCTGCTGCTGTGCGGCCATGTCTGGCATCTACCGCCGTCGCTCCCT TGA :::::::::::::Rv243T7.seq::::::::::::: CGACTCTGTTGGCCACTGCGGGTCGATCTTGCGGCCGCCCCGGTCGTGGAACGCCCAGGTCACCCGGCGGCGCACCGCGGTCAGCGCGTCGTTGGCCAGCGTGGTC (SEQ ID NO. 261) ACATGGAAGTGGTCGACGACGAGCTTGGCGTTGGGCAGCAGCCCGGGCGTGCGGATCGCCGAGGCGTATGCAGCGGCGGGGTCGATGGCCACCGTACTGGATGCTC TCCCGGAACTGCGGTGTGCGCGCTTGCAGCCATGCCAGCACCGCCGCGCCGCCGCGGCCTTCATGCTGCCCATAAACCCTGATACCGGCCAGGTCGACNAACCNGT ATCCCACGGTCAACCC Clone Rv244 :::::::::::::Rv244SP6.seq::::::::::::: CACACGGACGGCGGTGCGGACGCAGCTGACGCGCATGGTGGTCAGCATCGCGGCCGGTCTGCTGTTGTATGCCTACTTCGCGCCGCGCAAATGCTGGTGGGCGGCG (SEQ ID NO. 262) GTGGTGGCGCTCGCATGGCTGGGCTGGGTGCTGACCCAACTCTCGAACCACACCGGTGGGTGGGCTGGGCTATGGCCTGCCATATCGGCCTGGTGTTCTACN :::::::::::::Rv244T7.seq::::::::::::: CCGATATCCGAGCCGATAGCTGGCGGGCTCGGGTGGTNGCCAGCGGCGCTGCGACGAAAGTGTGACCGTCATGAAACAGACACCACCGGCGGCCGTCGGCCGTCGT (SEQ ID NO. 263) CACCTGCTCGAGATCTCAGCATCCGCAGCCGGTGTGATCGCGCTTTCGGCGTGTCGTGGGTCGCCGCCCGAGCCCGGCAAACGCCGGCCCGACACAACCCCGGAAC AGGAAGTCCGGTCACCGCGCC Clone Rv245 :::::::::::::Rv245SP6.seq::::::::::::: GCTTCAGGACAAATTGNATCCCTATGCACCCGTTGTCACGCCGATGAGTGAAGACTGCACGCAATCGCCGGAATCCGGCAAAACCCTGCACAAGCGAAATCAACCG (SEQ ID NO. 264) GAGGCTGACAAGGCAACGTCGGTGATCCGTACCGCCTGGTTGGACAAACGGCAGAAGGCGCCTCGTCCGGTCCATCTACGCCGAGCACACTGGTGATAGCGCCATC GGCATCGGTGCGGCCACGGTGGAGACGAACGTCCGCNGGCGTCTGGGTCAGTAACCCGCCGACCAGTTCTCGGGCAAGCTGGTCAACATCGGGCGCCACGTCTCCA AC :::::::::::::Rv245T7.seq::::::::::::: GTTTGGCGGCCTTATTGCACTGAGGTCGTCAATTGACCCACAGCGGAAATGCCGACTATTCGCAGGCCTCCTTCGCCTTGGCTGCCGGAGATGGGCTCCGCGGGAA (SEQ ID NO. 265) CCGCATGCAGGTATATGACCTCGGTTTCTCGGGTGCTACCGCGTGCCTTGTCGAGGATGAACTCGGCGTTGGAATTGTCCAGCCGGCCCAATTCATCGAGCGCAGA TTCGTACACATGGCCGGCGGCGACATACCTTCACCGTGGATCTGCTCCACACGGACCGCCCTGTCGGGATCTGCTCACGGGTAAAGGAATTA Clone Rv246 :::::::::::::Rv246SP6.seq::::::::::::: GCGCACTCCTCCTTATCGCTCCGCTCTGCATCGTCGCGGCGCGGTCAGGTGCAAACGCCTTCGGGGGTGGGGGTCCTGCGGAGCACACCGGATACGGAGCGCAACG (SEQ ID NO. 266) CGTCGCGTTGTGCGGGCAAACAAGTGTGCAGGNNCCAATGCCATGTCCAGCAGCTTATCAGTGTCGAACGTGCGAACGTCGCGCCTTCGCCGGTGCCTGAATCTCT ACAAG :::::::::::::Rv246T7.seq::::::::::::: CGCTGAAAGCCACCATTCGCGGGTCGGGCGCCGGGCTCGGGCCGCCAGGCTGCTCCGCTCGGTCATGGCACGCCACCGCGACACCACCCGGCTGCGCTACGTCGAG (SEQ ID NO. 267) CCATACCGGGCGGAGCTACATCGGCTCGGCCGCCTACTCTTCGGGNCCTCTTTCGAGGTCGAGGTCGA Clone Rv247 :::::::::::::Rv247SP6.seq::::::::::::: TGTAATTTGGGATGGGCAAAAAGCAAANCACCGCGTGGCCACAAACGCGGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGCCCGAAACGTACGGCG (SEQ ID NO. 268) TTTCAACACGTCGCGTCGCCTCCGACGCGAAATTCGGG :::::::::::::Rv247T7.seq::::::::::::: CTTGGGCAACATGCTGAGGATCGCCTTTTTCACCACGCGGTCGGGGTGGCGTTGCATTAGCTCACCGATGGTGCGCTTGTTGCAGGCCGCCGGGATACCCGAGTGCC (SEQ ID NO. 269) GGTAAACCATCTTGTGCTGCAGTTTGTCCCGCTGATGGCGACCTTGTCGCGTTGATCACGATGACGAAGTCACCGCCATCGACATTGGGGGCGAACTCGGCTTGTG CTTG Clone Rv249 :::::::::::::Rv249SP6.seq::::::::::::: GCATGCTTCATTATCTAATCTCCAGCCGTGGTTTAATCAGACGATCGAAAATTCATGCAGACGGTCCCAAATAGAAAGACATTCTCCAGGCACCAGTTGAAGAGGT (SEQ ID NO. 270) TGATCAATGGTCTGTTCAAAAACAAGTTCTCATCCGGATTGAACTTTACCAACTTCATCCGTTTCATGTACAACATTTTTAGAANCATGCTTC Clone Rv24 :::::::::::::Rv24SP6.seq::::::::::::: ATACTCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGATGG (SEQ ID NO. 271) CACGCCACCGCGACACCACCCGGCTGCGCTACGTCTATCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCATTGTTCNGGCCCTCTTTCGAGGTCGAGGTCTA TACCGATTTGCGCATCCG :::::::::::Rv24T7.seq::::::::::::: TCCGTACTGGTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGG (SEQ ID NO. 272) AATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAACCTCGGGTCCG Clone Rv251 :::::::::::::Rv251SP6.seq::::::::::::: GTTCTCGCACGATTTCGGATTAGCGGGATGGTCTCAATTGGGTATGCGGGGAAGGCGCTGACATTCGCCGCGATTAGCTGTTTGATGGACCGGGGGTGATTTTTGA (SEQ ID NO. 273) TCACGGAAATGGGTGTTTATNCAGGTCGCACGCTTTCATCCGGGGCGGAACG :::::::::::::Rv251T7.seq::::::::::::: GGGTGTGCCTGCTGTGTATGCACGGCATACGGACATCCTTCCCCTGAAGACCCGCGGTCGAACAGCCACGTGTCCATCATCANGGGGTCAACCCCGGCCAAGGGCG (SEQ ID NO. 274) ACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGAGCAAAACAGCTGGTCGGNCGTTAGGAATGAATTGAAACTCAACCGATTT GGTGCCGCCGTAGGTGTCCTGGCTG Clone Rv252 :::::::::::::Rv252T7.seq::::::::::::: ACTACCCGGCCAACGGTGATNTCTTGGCCGCCGCTGACNGCGCGAACGACGCCAGCGACCACATTCAGCAGATGGCCAGCGCGTGCCGGGCCACGANGTTGGTGCT (SEQ ID NO. 275) CGGCGGCTACTCCCANGGTGCGGNCGTGATCGACATCNTCACCGCCGCACCACTGCCCGGCCTCGGGTTCACCAGCCGTTGCCGCCCGCAGCGGACGATCACATCG CTTTTATTTNNTNTTCNGGAATCCCTCGGGCCGCGCTGGCGGGCTGATGA Clone Rv253 :::::::::::::Rv253SP6.seq::::::::::::: ACGTCGGGANACTGTTCGCGTTCATCCTCGTCTCGGCGGATTGGTCTGCTGCGCCGGACCGACCGATCTTCAGCGGGGGGTCACGCTCCGTGGGGTGCCGTTACTT (SEQ ID NO. 276) CCGATCGCCCAGTGTGCGCGTGCTGTGGCTGATGCTGAACCTCACCGCGTTGANTTGGATCGGTTCGGGATCTGGCTGGTGGCCGGAACGCNATTTATGTCGCTAC GGGCGCCGGC :::::::::::::Rv253T7.seq::::::::::::: GCTCAAAGGCACTACTGGCACCAAGGCCCACACGTCACCTGTGACTCCTGCGCCGACCCGCCCGAGGTCTGGCCGTTACACCGAACGGGCGAGCCGGGAGTTGGTA (SEQ ID NO. 277) CCATCGAACAAGACAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGTC CGATACCGGCTGCTTACCGAGACATCCACCATGCCACCCGAATCACCGCACGCGCCGAAATCGCACAACAGCTTGACGCCTTGCAGGTTCCGCGATTGGAATTGCC (SEQ ID NO. 278) GACGGTCTCTGACGGCGTCGACCTTGGCAGCCTCTACGAGCTCTCGGAATCACTTGCCCAGCAGGGGGTTCGATGAGTGTCACACCGAAGACCTCGATATGGGCGC AATCCTGGCCGACACATCCAACCGGGTGGTTGTGTGCTGCGGCGCCGGTGGGGTCNGCAANACACTACCGCGGCCGCGCTGGCGTTGCGCGCGGCCGAATATGGCC GCACTGTGGTCG :::::::::::::Rv254T7.seq::::::::::::: CGTCGTCGTCGTGGTATGCGATAGCCATCCCGTCGGGCTACTCGCCATCACCGATCAGCTTCGCCCCGAAGCCGCCGCGGCGATTTCCGCTGCGACCAAACTGACC (SEQ ID NO. 279) GGGGCCAAACCGGTATTGCTTACCGGCGACAACCGGGCCACCGCCGATCGGCTCGGTGTACANGTTGGCATCGACGACGTACGGGCCGGGCTACTGCCGACGACAA NGTCGCAGCCGTGCNGCNGCTGCAAGCTGGAGGTGCCAGATTGACCGTGGTCGGTGACGGTATCAACGACCTCCGGCCTTAGCGGCCGCGCATGTCGCATCGCCAT GGGCAGCGCCCGAC Clone Rv255 :::::::::::::Rv255SP6.seq::::::::::::: GCACGCAATCGAAGTCACCCAAACCGGGCGGGCCAGGCGTCTNACGCCACGTCNACCAGCCGCAACCTCAACCCGGCCACGGCGAGCTCCTGATCAAGGCCGAGGC (SEQ ID NO. 280) CATCGGTGTCTACTTCATCGACACCTACTTCCGCTCCGGGCAATATCCGCGCGAACTCCCGTTCGTCATCTGCTCCGAAGTATGCGGCACGGTGGANGCCGTCGGC CAGGGGTTAC :::::::::::::Rv255T7.seq::::::::::::: TCGACTGTGTGGCCACAGATCACGCCCCGCATGCCGAGCACGAGAAATGCGTCGAATTCGCCGCGGGCCGGCCGGCATGCTCGGGTTGCAGACGGCATTGTCGGTG (SEQ ID NO. 281) GTGGTGCATACAATGGTGGCGCCGGCTTGTTGANTTNGGCGCGATATCGCGCGGGTGATGAGTGANAACCGGCGTGCA Clone Rv257 :::::::::::::Rv257SP6.seq::::::::::::: GAACCTGACACCCTGGTCACGGGTGAGCACGGACTTGATTTCTTCNCTATTGGTCGGCGCTGTTGAGCACACCACGCCGCTGACGGCCGTCGCGTCCTCGCTGTGC (SEQ ID NO. 282) TCGGTCTGGTGGAGCGCGCTGCCCGCGGCCNAACATCNTAAATCAAGCGTATTCGTCAACAGATATCATCAATGTCGGCGCTGGACTATTCAAATCATCGATATAC TGGTGACCTGGTCCTTCGCCATCGATCAATGGCGATAGTCACGCAAATCGTCACGGACATCGTCGGCGTCCCAGCTGGCCCGTGCCAACAGATGCTGCAACCCATC GGGGTGGTATCACCGCGGTGCTCGGCGATGGTCCACAATTCTTGCGGTCCAAGCCCNAAACATCCCGGGCATGAATTCACCGGCATGCGCN :::::::::::::Rv257T7.seq::::::::::::: CTATCGTACCCGCGCCGGTCACCTTCTGGATATCGCCGGCCTGGTCAAGGGGGCGTCCGAGGGAGCCGGGCTGGGTNACAAGTTCCTGGCTCATATCCGCGAATGC (SEQ ID NO. 283) GACGCCATTTGTCAGGTGGTGCGGGTGTTCGTCGACGACGACGTGACTCATGTCACCGGACGGGTCGATCCCCAGTCCGACATTGAGGTCGTCGAGACCGAGCTGA TCCTGGCAGATCTGCAAACCCTGGAGCGGGCCACGGGCCGGCTGGAGAATGAAGCGCGCACCAACAAGGCGCGCAAGCCGGTCTACGAAGCGGCACTGCGTGCCCA GCANGTGCTCGACGCCGGGCAAGACGCTGTTCGCCGCGGGGGTGGATGCCGCCGCGTTGCGCGACTGAAACTGCTGACCACCAAGCCCTTCCTGT Clone Rv258 :::::::::::::Rv258SP6.seq::::::::::::: TACTCAAGCTTCAGGCCGCCACGTCCGCCGTCCGTCGGCGACGTGACCTCGAGCGCCGAGTTCGACTCGACATCGCCGCCGGCGCATGCCGACATGAACGCGGCAC (SEQ ID NO. 284) TCACCGCAAGCCCGTCGGACGTCAGGTCGATCGACTCCGCTTCAAGCACCGGATCGTCCGGGCAACTCGCGGCCTCGGCCTGTGCGAACGGCACACCCGTCGTGGC GGCNCCCCGCGCGGAACTGGGCTCATCACGGTCGTTGCGAGCCGGTCGCGTCACCGCGTACCGACGCCGTC :::::::::::::Rv258T7.seq::::::::::::: CCGACATCGAGTGGGCTCGCAGTGACTTGGCGACCTCCAAGCCACCGGTACCCGCCGCGCGGCAAGCCAAGGACGACGACGGCCTTGCCGGATAGCTGCGCCAGGC (SEQ ID NO. 285) GTTGCGCCAACTGGCGTCCAGCGTCGCCACGATCGTCAAAGAGCTTCATCTGCCGAGTGTGTCGCCATCTCATGGCTCCAAATATGGAATTAGGTCCCTGGGCCGA CTGACGACAGTCCCTCAGCGACCGGATTGCGCATCCCGCCTTGTACGCTACTCCGCAAATCCCGGGCTTGCGTCCGCGGAAGCGAACTCGGCGGCGCTACGTGGTG GTTCACTTCGGCCGTGCGCACTCGGATCGACGGGCCGATGGTGGCCGGGCCCGCGCGCTTCTTGGTCATCCGATTGAGT Clone Rv259 :::::::::::::Rv259SP6.seq::::::::::::: ATACTCAAGCTTGTCGCGGTAAACCGCACGCAGGGCGGTGGGTGCGGTGTCAAAGACACCCACACTTCTTTGCGGTTCGGTGATCTCGACACCGGCCGCGAGCCGA (SEQ ID NO. 286) CCACCATGCGCGCGTAGATCGGCGATCAGCGCGTCGGCTATCGCCTGGGTGCCGCCCACCGGAATCGGCCAGCCGACCGAATGGGCCAGCGTTGCCAGCATCAGTC CGGCGCCGGCCGACACCAGTGACGGCAACGGTGAAATCGCGTGGGCGGCAACGCCGGTGAACAACGCGCGGGCATCCTCGCCCGCCAACGACCGCCAGGCAGGGTG CCTGGGCCATCATCCGCAGCCCGA :::::::::::::Rv259T7.seq::::::::::::: TGGACTCATAACGATCGGGTCAGCGACGCGCCAACACGAACGGCCGGACGAGTGGGCCAGGGTCGCGCCTCCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAG (SEQ ID NO. 287) GCTCCGGTGCGGCGTTGGGCGCCGTGCTCGTCCCAGCGTCCGGTCCCGGGTCGCCGGCGACGCTTGTTTCCTCCATACTCGCCCCCTAATCTCGAGGCAGCCCGTA CCCGCAGGCAACCTCCCAAAAATGCAATCCCCCAAAATGCAATGCGTCGAGCTATTTCTCACACCGACCGCTAGTTGCGGATCAGAAATCCGTTGGGCGCGGAAGT CCAGCCGAATTTGTTCTCCCGCTCCGCATCATGCTTGTAATCGTTTGGAAATCATCCTCATATGCCTCGATCGCTTCATAGGTCAAGCCCAAACCCGGCAGGATGG GTGGCC Clone Rv25 :::::::::::::Rv25SP6.seq::::::::::::: CTTTACACTTTATGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTG (SEQ ID NO. 288) ACACTATAGAATACTCAAGCTTAGTGGTTGCGCACGTAAATTCGTCAGGTGACCGATCCCCTGCTGTCTCACTCGCCTCACAGCGACCACCACGGCTGGCGCTCAA GGCGGGCACGTGCGGAGCAGATGAGGAATGTGCGACGTCTTGATGCAGCCTGTCAGAACACCGAGACCCTCGACGAACTTACGATCGAAACCGCTTAGGCCAACCG GTGACGGGGGTGTCTTTCCGCGGCTAGGGCGCCTTATCGTCCGAAGGCCGTGGGTGGTGATCGCCTTCTGGGTCGCGCTTGCGGGTCTGCTTGCGCCGACGGTGCC GTCCCTGGACCGATCTCCCAGCGGCATCCAGTGGCGATTCTGCCATCGG :::::::::::::Rv25T7.seq::::::::::::: CAGGCATGCAAGCTTGCGATGTATCAACACGCCGTTGCGCAGCGTGAGCCGATAGTTGACATCCGGCTCGGTGAAGGTGAAATCGATGGCCAGGTCGAGGTCCCAT (SEQ ID NO. 289) GCGCGTGGGCCATTGATGCTGATCGCCAGGACGTCAAAGATTTGGTCCGGCGTCAGCTGGGCGAAAAACGTGGGCGCCGGGACTTGCCCGGAGCTGCCCGGGTTCC CGTCGCGCAGCTCGGCGGCCCCGGTCAGAAAGAAATTGCGCCAGGTCGCACACTCCGCGCCGTAGGCCAGCTGCTCCACGGTGTCGGCATATAGCCCGCGGGCCGC AGCGTGCTCGCTGTCGGCGAACACCGCATGGTCGAGAAGCGTTGCCGCCCAACGGAAATCACTGCGTCAAAGCTTCGCCGGGCCACTCCAGCACTCCGTC Clone Rv260 :::::::::::::Rv260SP6.seq::::::::::::: ATACTCAAGCTTGACCGACGCTGATCGCACCGCACGCGGGAACCTCAAGGGCACTACTGGCACAAGGGCCCACACGTCAACCTGTTAACTCCTGCGCCGACCCCGG (SEQ ID NO. 290) CCGAAGTCCTTGGCGTTAACACCGAACGGGCCAACCCGGGAATTTGGGTTCCATCAAAACAAATAGCAGGTGCCTGGGCGGAGTGTTC :::::::::::::Rv260T7.seq::::::::::::: GTCGTCGTGTGCTGGGGCGTCCGTATCAGCACGCCCACGAAATGGGGCACAAGAAGGATTCCTGGAACGGTGGCTGTCCAAGATCACCCTCGCCCAAAACTGCTAC (SEQ ID NO. 291) GGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCCGCGGTGTCCACACCGGGAGG Clone Rv261 :::::::::::::Rv261SP6w.seq::::::::::::: ATATGCCTTGCTGAGCTTTTCGGATCGCAGCGAGTCGTACCCGCGCCGGTCACCTTCGTGGATATCGCCGGCCTGGTCAAGGGGGCGTCCGAGGGAGCCGGGCTGG (SEQ ID NO. 292) GTAACAAGTTCCTGGCTCATATCCGCGAATGCGACGCCATTTGTCAGGTGGTGCGGGTGTTCGTCGACAACGACGTGACTCATGTCACCGGACGGGTCGATCCCCA GTCCGACATTGAGGTCGTCGAGACCGAGCTGATCCTGGCAGATCTGCAAGCCCTGGAGCGGGCCACGGGGCGGCTNGAA :::::::::::::Rv261T7.seq::::::::::::: GACACCCTGGTCACGGGTGAGCAGGACTCGATTTCTTCGCTATTGGTCGGCGCTGTTGAGGCACAGCACGCCGCTGAGGCCGTCGCGTCCTCGCTGTGCTCGGTCT (SEQ ID NO. 293) GGTGGAGCGCGCTGCCCGCGGCCGAACATCGTAAATCAAGCGTATTCGTCAACAGATATCATCAATGTCGGCGCTGGACTATTCAAATCATCGATATACTGGTGAC CTGGTCCTTCGCCATCGATCAATGGCGATAGTCACGCAGATCGTCACGGACATCGTCTGCGTCCCAGCTGGCCCGTGCCAACAGATGCTGCAACCCATCGGGGTGG TATCNCCGCGGTGCTCGGCGATGGTCCAACAATTCTTGCGGTCCAAGCCCGAAACCATCCGGCCATGAGTTCACCGGCATGGCGCAACGGCTGGTGCCGGGCAAAA CGCGGCGCGATCGAATTC Clone Rv262 :::::::::::::Rv262SP6.seq::::::::::::: TGTAGAAGGTGGGTCCCGTCCAACTTCGCGGCGGCGGCGCGATATGCCTTGCTGGTCTTGCTCATTTGATATCCAATCTATGGGTCGTGGTTACTCAACGGGCCGA (SEQ ID NO. 294) AGCTGGCCCTCCCACGGGTAGGGTCCTATTCGACGGTGATGTCC :::::::::::::Rv262T7.seq::::::::::::: CCCGAATCCGGTGGCCGGCAGGGGGCCTGGCGACGTGGACACCTTCTAACTTGTCTTTACCGGTCACTGTTGCACCCCAACACCTTTAACGACGTGGACGGACGTT (SEQ ID NO. 295) ACATCGGATTCGACGGTGTCATCCACAGCGTTGCCATTGGGCACACCCACTACGCCAATTTCTCCGACTGGGACACCTACCGCAGCCTCGCCCCACTGCAGGGACT GTTGTTCCCGCAACGGGCCATCGACATGATCCAGTCGTTGGTGACCGACGCGGAGCAGACTGGTGCGTATCCGCGTTGGGCGCTGGCGAAATTCCGCCACCGGCAT GAT Clone Rv263 :::::::::::::Rv263SP6.seq::::::::::::: TTGAGATGCTGGTCGGGATGCCGATGGTTGGAACATGGTCCCCTGGCGTCGAATACGCGCGAGCGCATGAGCTCACCGGTTCGGAACAACGTATCGAAGAACTCGC (SEQ ID NO. 296) ACTGCTGGCAGATGGTATCTCCGATGTGGTTGTAATTTGTATCCCAACTCTAACTGTGCTATCGGATCTGCGTGAATA :::::::::::::Rv263T7.seq::::::::::::: CGTAATCACGATCCCGCTGAGACACTTGACCTTACGGCCGAAGTGACTTCGCTGCTGCTATGCCGACACCCGATTTCCATACGCTGCTGTACACGACGGCCGGGCC (SEQ ID NO. 297) GGTGGCCTCCATCACGCTCAACCGCCCGGAACAGCTCAACACCATCGTCCCGCCCATGCCCGACGAGATCGAGGCCGCTATCGGGTTGGTCGAACGCGACCAGGAC ATCAAGGTCATCNTNCTGCGCGGTGGCGGGCGCGCCTTCTCCGGCGG Clone Rv264 CAAGCTTAAGCTGGTTCCGGCCACTCCATGAGCCGTAGTGCAATGGTTCGTGCACGGCGAGGCCGAACTTGCCATAAACATCCCTGACGAAAGTCTCCGGCAAGCC (SEQ ID NO. 298) GATTGCTTCTTCGGGCCGCTTCTTGTGGATTGTCCGATAACCCGGTCCCTCATGCTGGAAGTTGTGCGCACTCTTTCCTTCCGCGATGTGGGCTAACGACTCGTCA TTGAGCAAGAAGTACGTGCACAGGCATCGTCCGCCGGGCTTCAGCACGCGGGAGATCTCGTCCAGATAGTGCTCCACGTCCGGNGGGAAACATGTGGGTGAACACC GAGGTNAGAAACACCNCATCCAACGACGCATCCGGGATATGGAAAGCGAAA :::::::::::::Rv264T7.seq::::::::::::: TATGGTCTTCGTCGACCAGTACGTCGTAGGCGCCATGAGCCAGCGACTGAAGCCGCGCCATGCCTGCACGGCCCGCTCATCCAGCGAGGCGGCCATCTCCCGCAGA (SEQ ID NO. 299) TAGCCTGCCGCCTCGGCGCGCACGCTGTCCGGATCGCGTCCGAGCTCGTCGGCCAGCGCACGCAGCCGCTCGTCATACCATCGGGCATCCAGCAGTTGGGTAACCT CAACGGGGTCGGTCGCTAGCGGCGTCATTGATTCAGCAACAATACCGATGCGCTGCAGCAACTTTCGCAGTCCGATGCGGCCCACCTCCCGTGCAGTCACTGGCTA GCCCCCGTCATGCCGGTTGTGTCGATGGCACGGCAGCGGGCTCGTAAACCTGCGGTCTCAGCTCGCTGG Clone Rv265 :::::::::::::Rv265SP6.seq::::::::::::: GCTTAGCGGTCTTGCTCGAACCGACATTGCGTGCCACTCATGAGCGGGTGGCGGTCGCGGTGCTTACACATCT (SEQ ID NO. 300) :::::::::::::Rv265T7.seq::::::::::::: GTATCTGGCGCCTCTCGAATATCCTTGAACGTCCCGCGGTGCCACCCAGATAGATCGCAGCGCCCTGCAATGGAGTTCCCTTTATGGCCTCTCTAGCCTCCCGCTT (SEQ ID NO. 301) GATCGGCTCGACCCGAGAGATGCCCTCGGGCGTTGCGGGATCTCCCTCCA Clone Rv266 :::::::::::::Rv266SP6.seq::::::::::::: CTTCACGCCGATCCGCGACCGCGAACGCGACGGTGACGGTGGGCGACAAGGTTCGGTTGGTCGCCGCGGCGCTGGGCGATATCAGCTCACCCGGTTTCGAGGTGTT (SEQ ID NO. 302) CGGCGACCGGACGGTGCTGCAGACATTCTTGAGCGTCCTCGACCGGCCCGATTCGGCCTTCAACATCGTGACGCCGTATTTCGGCGGTACCGCTCGGCGCCGAGTC GAAGGCGGCCTGAGCTAAAGCCGGGCATTGCGCGAGTGGTAAACAAGTTCGGTGACTTCGGTTGACCGACTCGACGGGCTCGATCTGGGCGCGCTGGACCGGTATC TGCGTTCGCTGGGGATCGGGCCNACCGCNANTTGCGTTGCGANCTGATTCCGGTGGAGCTCCAATCTGACTTCCGG :::::::::::::Rv266T7.seq::::::::::::: GCAGCTACCGACCCTAGCGACGAGTGTGTTCGCAGCGTCGAATGTGAACGTTCGGCGTGATTCGGCGCGCGGGTTCCCGCTCTCAGCGCACGTTCGGCGCCGAGGN (SEQ ID NO. 303) GGCTAGTCCCTGGTTAAGCAATGTCTCGGTCGCCGCCAGCAGCGCGCATGTCGCCAACCCGTCNACCGCGTTGCGCATGTCCGGTACCGACGGAAACGACGGCGCG ATCCGGATGTTCTTGTCGTCCGGATCCTTTCGATACGGGAACGACCCCCCGCCTCGGTCACCGCGATACCAACGTCCTTAGCCAANGCTACNGTCCGGCGCGCGGT CCCGGGCAACACGTCGAAGCTGATGAANTAACCACCCTTGGGCTCGGTCCAAGANGCGATCTTGGACTCCTTAACCGCTGATNCAA Clone Rv267 :::::::::::::Rv267IS1081N60.seq::::::::::::: TCCCCATCGGCGCCGGACCGTTTGAAAGTCCAAGCACGGGTGGGATGGAATCGACGACAGTTGAGCGCCGTCGGTGGCCGTGGTCAGCAGCTGTTCGCGAACGCAC (SEQ ID NO. 304) CAGGTCACATCCCTTCGACATCTCACCGACGTGGCACGGGCGACATCAACAGGAAGATTGACGAATCCCTCGCAGGCGCGGCACGTCCGCAGGCCAACGCCAACTA CGGGGCCACCAGCGATCCTCCGCTCACGCACCAGCCCAAGCCAGGCTCANCCACCCAAGTCGGCCCGCGCTCTCCCTCGCCCCCTGGTCTCCGGGGCCTTGTTAAA CAACTACCGGAAGTCCACCAATCCTCGCTGCATCTCGACACCGTCCGCCTCACTCCCTTCCTCCCGCCCCTCTCCACACNACACACCTCTTGCATTAAGGTCACGG AGCGGTCACTTTTCGTCGGACGAAATTCGCAATCCGGCCGCTCGCCGCCAGAGAT :::::::::::::Rv267SP6.seq::::::::::::: CGGAAAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCAGCTCGCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCT (SEQ ID NO. 305) GGCGCAGCTTGGGGATCGCGACGTCGATGGTTGCGGCACGGGTGTCGCAAATCACGGTGGCGGTAGCCGTTGCGCTGATTGGACCGCTCATCGCTGCGTTCGCGGT AGCCCGCCCCGCACAGGGCGTCGGCTTCAGCCCCCATCAAGGCGGCGA :::::::::::::Rv267T7.seq::::::::::::: GGCCGAGTCCAGCACTTCGCACTATGTGCAGACCAAANACCCGGTGGTCGCCGCGCTGCGGCAGCGGCTGGCAACGGCGCCGGTGATCACCGAGTGGTGCGNAGTT (SEQ ID NO. 306) GCCGACCGGCAGTTCGCCGCGGGCTTACTACGAGAAGGGCCTGCGCGACGTCATCAGGTATCACGTGTCGATGACGTCGAGCGTTAACTTCCCCGACCAGACGGCG ACCTCGCCGATGGACCCCGCGTTGTACCTGGTGTGGGCGCAAGCTAACGCCGCCGCANGCTATCGGTACTCGGTCGAAGCGCAGCCGGGGTCGCAAGCGCTAGCGG GCAAGGTCGCGACGATCTCGGTCACCTGGACCAACTACGGCGCTGCTGCCGCCACCGAATAGTGNGTGCCCGGCTACCGGCTGGTGGATTCCACGGGACATGTGGT TCGGACCTGCCGGCAGCGGTGGAACTGAAGANGCTGGTCT Clone Rv268 :::::::::::::Rv268SP6.seq::::::::::::: AGCTTCAAGGACATCGTCATCGCGACCAAAACCGCGAGCTAGGTCGGCATCCGGGAAGCATCGCGACACCGTGGCGCCGAGCGCCGCTGCCGGCAGGCCGATTAGG (SEQ ID NO. 307) CGGGCAGATTAGCCCGCCGCGGCTCCCGGCTCCGATTACGGCGCCCCGAATGGCGTCACCGGCTGGTAACCACGCTTGCGCGCCTGGGCGGCGGCCTGCCGGATCA GGTGGTATATGCCGACAAAGCCTGCGTGATCGGTCATCACCAACGGTGACAGCAGCCGGTTGTGCACCATCGCNAACGCCACCCCGGTCTCCGGGTCTGTCAN :::::::::::::Rv268T7.seq::::::::::::: GCTCGCGGTCCAGCAGCAGACGTGTCTGACCCCGACGCCCGGCCGCCGGTACCGAAACCGGATCGGCCCGCCGATGGCCGCGGCCACGGCGTCTGCCTTACCCGGC (SEQ ID NO. 308) CCGGATACCAGCAGCCACACCTCGCGGGAACGCTGAATCGCCGGCAGGGTCAAGGTGATTCGGCGTGGCGGCGGTTTCGCGAATCGTCCACCGCCACCACCATGCG GGTGCTCTCGAAGACGCGGGGCTGTGCGGGAACAGCGAGTTAATGTGGCCCTCGGGCCCCATGCCCAGCAGGTGGACGTCGAAATTCGGCCCGGGTCACCTGGTGC GGCACTGGCGGCC Clone Rv269 :::::::::::::Rv269SP6.seq::::::::::::: AGCTTGTCGATCGTCCGGCAGCGTCCGGCGAGTCAAGTCGAAGCCAGTCCGGTCTCCTCTCCGACTACGGCCAAGAACTGGGCGACGGTGTCAGTGCATACCAGCG (SEQ ID NO. 309) GANACTGGTGGCGCCCTAGGCGAGCGACCGCCTCACAAACGGCGGTGACCGCGTTCTGGTCGTGCACCATCGAGCCGTGCCCATCCCGGCCGCGTGCCGTCAGCCG CATCCACTGGATGCCCTTCTCGGCGGTTTCAATCAGGTACAGGCGACGTTCGCCANCATCGTGCCGGGGCANGG :::::::::::::Rv269T7.seq::::::::::::: TTGGTGATCATCGNCCCAACGACCCCGAGGCGATGTTCTTGCACACCGAGGAGTGTCGCAAGCTGGGGCTGGCCTTCGCCGCCGATCCGTCTCAGCAGCTGGCGAA (SEQ ID NO. 310) GCTGTCGGGGTGAGGAAATTCGCAGGCTCGTCAACGGTGCTGCTTACTTGTTCACCAACGACTACTAATGGGATCTGCTGCTGTCCAAGACCGGCTGGTCAGANGC CGATGTGATGGCGCAGATCGACCTGCGGGTGACCACATTGGGTCCTAAGGGTGTCGATTTGGTAGAACCTGACGCACCACCATCCACGTCGGCGTTGGTCCCCGAA ACAGCCAGACCGA Clone Rv26 :::::::::::::Rv26SP6.seq::::::::::::: GGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAG (SEQ ID NO. 311) CTTGATTTTGATCATCATGATGATCATCACCCGAAGTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGGCTTTCCGTA TTGGTCTGGCAGGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGCTGCTGATTT CCCGGTTGAAAGAGGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGACGGCTGCCGGCATGGTGTTCGCCGTTAC CATGTCGTTGTTTGTGTTCAGCGATTTGCGAATT :::::::::::::Rv26T7.seq::::::::::::: CAGGCATGCAAGCTTGGCGTGCCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACC (SEQ ID NO. 312) TCGATGCTGCCGCCATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCG GATCGCGGTGATCGTCGATGACGGCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCNCCCGGGCGCACG Clone Rv270 :::::::::::::Rv270SP6.seq::::::::::::: GGCATCTTGGCCGCCATGTTAGCCACACTGCCACCGGCTATAGAAGCGATGCGCACCGTCCTGCCAGCACATTGCGGCGCTCCTCCCTGGAAAGCAAGATAACCAA (SEQ ID NO. 313) GCTCATGCCGTGGTTGTGGGTGGCGTGGTTTGGTTTGGGTAACTTTGG :::::::::::::Rv270T7.seq::::::::::::: TCGGCTAATAATCGTCGACGCCGGCCTCCTCTGCAATCGCCTTGGCGGTCGCCGGGTTGTCACCGGTGATCATCACGGTGCGGATGATCATTCGGCGCATTTCGTC (SEQ ID NO. 314) GAATCGTTCCCGTATGCCCACCTTGACGATGTCCTTCAGATGGACGACGCCGATGGCCCGCGCGCTGCTGTTATCGGTCCATTCCGCAACGACTAGGGGTGTCCCC CGCCGGAGCTGATGCCGTCGACAATGGCACCCACCTCCTCGGTGGGGTGGGCACCGTGATCGCGAACCCACTTCATCACCGCAGCCGCGGCACCTTGCGGATTCGA CGGATG Clone Rv271 :::::::::::::Rv271SP6.seq::::::::::::: CTCAAGCTTGGAGGCGTGGCGATCGCGGTCCAAGGCGCGCTCTCCGAGCACAACGAGCGAAGACNGCTCGGCGACGGAGCCTTTATCGACNTCCGTTCGGGCTGGC (SEQ ID NO. 315) TGACGGCGGCNAAATAATGCTGGACTCGTTGTTGTCGACGGTGCCGTGGCGAGCCGAGCGCCGTCAGATGTACGACCGGGTGGTCTATGTGCCGCGGTTGGTGAGT TTCCACGACCTGACCATCGAAGATCCGCCGCATCCGCTGCTGGCGCGGATGCGCCGGTGGCTCAACTAATTCTACGGCGGCGAACTGGGTNATCCCTTCNCCACCG TCGG :::::::::::::Rv271T7.seq::::::::::::: CCTAGGTCAACCGTACCGTCATCGGATCGGGGTCGACCGCACAGATGGACTGGAGCTTCGGCGAGGTCATCGCCTATGCCTCGCGGGGGGTGACGCTGACCCCGGG (SEQ ID NO. 316) TGACGTGTTCGGCTCGGGCACGGTGCCCACCTGCACGCTCGTCGAAGCACCTCAGGCCACCGGAAATCATTCCCGGGCTGGCTGCACGACTGCGACGTGGTCACCC TCCAGGTCGAAGGGCTGGGCGAGACGATGCAGACCGTCCGGACGAGCGGCACTCCTTTTCCGTTGGCTCTTCGGCCGAATCCGGACGCCGAACCCGACCGGCGCGG GGTCAACCCGGCACCGACGCGGGTGCCGTTTACCCGCGGGCTGCACAAATCCCGACGGGTATGGGCTTTGACCTGCCGACGGGGGA Clone Rv272 AGCTTGGCGTGACACCAACACAGGGCACTTAAGATGGCAATGCGCCGCCTACCTGCACGTTTTCGCGATGTCAGAGGATGCCGAGGGGAGAACAATGCGAGCACGG (SEQ ID NO. 317) CCGCTGACGTTGCTCACCGCTTTGGCGGCGGTGACATTGGTGGTGGTTGCGGGCTGCGAGGCCCGAGTCTAGGCCGAAGCATATAGCGCGGCCGACCGCATTTCGT CTCGACCGCAAGCGCGACCTCAGCCGCAGCCGGTGGAGCTACTGCTGCGCGCCATCACGCCGCCTAGGGCTCCGGCGGCGTCGCCGAACGTCGGGTTTGGCGAACT GCCTACCCGGGTCCGGCAGGCAACCGAT :::::::::::::Rv272T7.seq::::::::::::: TCATGCCGTTGGACCGACCATCGGAGTTAGTTGCCGAACCGCGGGACCACCGCAAGCACCCGGTCCTGGTCGCGCACCGCGTCGGCCAACCGCTTGAGCACCACCA (SEQ ID NO. 318) CGCCGCAGCCCTCGCCGCGCACGAATCCATCCGCGTTGGCGTCGAAGCTGTTGCATCGGCCGGTCGGTGACAGCGCCGACCACTTGGACAGCGCGATGGCGGTGAA CGGTGACAAGGTGAGCTGCACCCCGCCCGCCAATGCCACGTCGGTTTCACGCAGGCGAAGCTCTGACACGCCAAGTGAATTGCCACCAGCGACGACGAACAAGCGG TATCTACGGCGATGG Clone Rv273 :::::::::::::Rv273SP6.seq::::::::::::: GGGTCGACTTTCTGCAAGGCGAGGCTACACCGTCGTCGTCGTGGTATGCGATAGCCATCCCGTCGGGCTACTCGCCATCACCGATCAGCTTCGCCCCGAAGCCGCC (SEQ ID NO. 319) GTGGTGATTTCCGCTGCGACCAAACTGAACGGGGCCAAACCGGTATTGCTTACCGGCGACAACCGGGCCACCGCCGATCGGCTCGGTGTTCAGGTTGGCAT :::::::::::::Rv273T7.seq::::::::::::: AATCCGAAATCCTGACCGATACTTGAACCTGGTCTCGTTCGGCAATAACTCGTCGGCGTGCAGGACGCGGCGCAAACGTACTTCGGCATCAACGCGTCCGACCTGA (SEQ ID NO. 320) ATTGGCAGCAAGCGGCGCTGCTGGCCGGCATGGTGCAATCTAACAGCACGCTCTTCCCGTACACCAACCCCGACGGCGCGCTGGCCCGGGCGGAACGTGGTCCTCG ACACCATGATCGAAAAACCTTCCCGGGGAGGCGGATGC Clone Rv274 :::::::::::::Rv274SP6.seq::::::::::::: TTCCGAATTTCGGGTCCNGGTCATATGACCCTCATGGAAGAAGAAGCGGCCGCCCCGCGCCCGTGCGACGGCGAATGAAAACCCTCACCCAGGCCGCATTGAACGC (SEQ ID NO. 321) CGACAAGACGGTGGAGCAGGTCGAAGACGTCCTGGACGGTCTGGGTAAGACCATGGCCGAGCTGAACAGCTCGCTGTCACAGCTGAACAGCACCGTGGAGCGCTTG GAGGACGGTCTGGACCATCTCGAAGGTACCCTGCACAGCCTGGACGATCTCGCGAAACGGCTCATCGTGTTGGTCGAGCCGGTGGAAGCCATCGTCGATCGGATCG ACTACATCGTGAGCCTCGGCGAAACGGTGATGTCACCGCTGTCGGTC :::::::::::::Rv274T7.seq::::::::::::: NCTCGATCTTGGGGTACGTTCGATGAGGCTGCTGACCAACAACCCGGCCAAGCGGGTGGGACTGGATGGATACGGATTGCACATCATCGAGCGCGTGCCGCTGCCG (SEQ ID NO. 322) GTGCGGGCCAACGCGGAAGAACATCCGTTACCTGATGACCAAGCGTGACAAATTGGGGCACGACTTGGCTGGGTTGGACGATTTTCACGAATCCGTGCATCTGCCC GGAGAATTCGGCGGTGCCTTGTGAAGGTGGCGCCGGGGTGCCGGATCTGCCGTCGCTGGATCGTCTGGTGTGCGGCTGGCGATTGTCGCCAGCAGCTGGCACGGAA AGATCTGCGACGCGCTGTTGGACGGCGCCCGCAAGTGGCCGCCGGGTGTGGCCTCGATGACCGACTGTGGTTCGGGTGCTCCGCGCGATCGATAT Clone Rv275 :::::::::::::Rv275SP6.seq::::::::::::: TCATCCCGACCAAAACGCGAGCTAGGTCGGCATCCGGGAAGCATCGCGACACCGTGGCGCCGAGCGCGCTGCCGGCAGGCCGATTAGGCGGGCATATTATCCCGCC (SEQ ID NO. 323) GCGGCTCCCGGCTCCGAGTACGGCGCCCCGAATGGCGTCACCGGCTGGTAACCGCTCTTGCGCGCCTGGGCGGCGGCCTGCCGGATCAGGTGGTAGATGCCNACAA AGCCTGCGTGATCGGTCATCACCAACGGTGACAGCAGCCGGTTGTGCACCAAGCGCGAACGCCACCCCGGTCTCCGGGTCTGTCCAACCGATCGACCGCCCAAGCC CACATGAACAAACCCCGGCATCACGTTGCCGATCGGCATACCGTGA :::::::::::::Rv275T7.seq::::::::::::: TTGGCGGGTTGGCCCAGCAGCCCGCCGGTGACGGCGACGATGCTGGGCTGGTTGCGGCCCTGCGCCACCGCGGCTTGCATGCTGGTTGGCTGTCTTGGGACGATCC (SEQ ID NO. 324) CGAAATAGTCCACGCGGATCTGGTGATTTTGCGGGCTACCCGCGATTACCCCGCGCGGCTCGACGAGTTTTTGGCCTGGACTACCCGCGTGGCCAATCTGCTGAAC TCGCGGCCGGTGGTGGCCTGGAATGTCGAGCGCCGTTACCTACGTGACCTGATGGATCGGGGGGTGCCGACCGTGCCCGGCGATGTGTATGTGCCGGGANAGCCGG TCCGGTTGCCACGCAAAGGCCATGTCTTCGTCGGTCCGACCATCGGTACCGGGACACGGCGCTGTATTGCCCGGTTCGCTGCCGAGTTCGTCGCGCAACTGCACGC NGGCGGGCCAGCGGTGCTCGTTCANCCCGGAGGTTCCGGTGACGATGATCGTGTTGGTCTCCCT Clone Rv276 :::::::::::::Rv276SP6/seq::::::::::::: GTAGGAGAGAACAAAGACCGTCGATAGGACACGTGTTACGCCGGTAGCTGTCATTGGTATGGGGTGCCGCTGCCGGGGGGCATCTACTCACCCGATCGGTTGTGGG (SEQ ID NO. 325) AGGCGTTGCTGCGGGGCGACAATCTGGTCACCGAGATCCCCGCCGACCGCTGGGACATCTACGAGTACTACGACCCCGAACCCGGCGTGCCCGGACGCACCGACTG CAAATGGGGCGCGTACCTCGATAACGTCGGCGACTTTGATCCCGAGTTCTTCGGGATCGGGGAGAAAGAAACGATAGCGATCGATCCGCAGCACCGCTTGTTGCTG GAAACCTCCTGGGAAGCCATGGAACACGGCGGGCTAACACCGAACCATATGCCTCCCGACANGGGTTTTCGTGGGGTT :::::::::::::Rv276T7.seq::::::::::::: CGAACTGAGCCCATAGAAAGGCAGCGACTAATTCGCTGGGCAAATAGGAAGACCCTTTGTCCTGCCACGTATATTTGTCGACCTCGTTGCGAAGGAAGCGGCTGCG (SEQ ID NO. 326) ATTGGTGCCCTTTTCCCTGGAGAATCTCTGCCCGGAGCAGGAAGTCTTATGAGTTGACAAGCAGGGGCGCCGCCTTCGCCGGAAATCACATTCTTGGTCTCGTGAA ATGAGAGCGCTCCCAGGTCGCCGATGCTGCCGAGCGCCCGCCCACGATACGACGCCATCGCGCCTTGGGCCGCGTCTTCGACCACCGCCAGGTTGTGGTGCGTGGC GATCTTCATGATCGCGTCCATCTCGCAGGCCACCCGGCATAGTGAACGGGGACCATGGCCTCGGTTCGCGGGTGAA Clone Rv277 :::::::::::::Rv277SP6.seq::::::::::::: CTTAGACGCCACCTCCGGGCCGAGCTCCACGGGGTGGATAAGTACGGCCGGATGTGGCCGCAATGGGAAGTTGTTGCCCGCTTGACTGTCCGGGTTAACGCCGGAT (SEQ ID NO. 327) TCCACCACATCCCCTTGCGAAAGGCCGTTGGGTT :::::::::::::Rv277T7.seq::::::::::::: GATCGCGATCGTCGATGTGGCCATCCGGCTTGGCGTCGACCCGCGTAAGGCAGACCAGATGGTTCGCGGCACGGTCAACCTGCCACACGCACTGGTAAGACTGCCC (SEQ ID NO. 328) GCGTCGCGGTATTCGCGGTTGGTGAAAAGGCCGATGCTGCCGTTGCCGCGGGGGCTGATGCTGTCGGATCGACGATCTGATCGAGAGGATCAGGGCGGCTGGCTGG AATTCGATGCCGCGATCGCGATACCGGATT Clone Rv278 :::::::::::::Rv278SP6.seq::::::::::::: AGCTTACGCCGCTTTCGCTTCNGATTTGGGACGCCGCATCGAAAGCGCAGTTGGAAGCGCGGCGCCCGGCTGGTCGAGCTGCTCAAGCAGCCGCAATCCCAGCCCA (SEQ ID NO. 329) TGCCCGTTGAGGAGCAAGTGGTTTCGATCTTCCTGGGCACCGGCGGTCACCTGGACTCGGTGCCCGTCAAGGATGTCGGCGGTTCGAAACCGAATTACTGGACCAC ATGCGGGC :::::::::::::Rv278T7.seq::::::::::::: CGACGGGACCTCGTCGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGGAATCCAACCGGTATAAGGTCGGCGAAGCGCTCGGCATTGGTCATCGGGATA (SEQ ID NO. 330) TGCCGCTCGGGACGGTCAGATGCCCTCGGGTCCNGCCAGCACTCCTCAGGCTTCGTCGGGGTGGTCGCGACCGCATGGGCCACATCGCATTCACCAGGTCTGCGCG AATCACCAGCACGTANACGGTTCCTTTCCTAAGCAACACCGAAATTTCAGGACCCGAATGCTCCGGGAAAACATGTCACGGTAAGTCCGGTATTCCGGGTACCGGT TGAGCATTGA Clone Rv279 :::::::::::::Rv279SP6.seq::::::::::::: CGGCATCGGTTTGGGCTGTCACCAGCAGTTGGTAGTTCTTCACTACTGTTGTTCGAGCGTCGAGCCGCCGCGCGTGTCGAGGTCGCCGGACGCGTACCCGCCAGGC (SEQ ID NO. 331) CGGTCAGGGTGCCCTTCCAGTCCACGCNGCTGTGGTCGGCTAACCGCTTATCTTCAATCGAGACNATCGCCAGCTTCATCGTGTTGGCGATCTTGTCCGAGGGCAC CTCGAACCGGCGCTGCGANTACAGCCACGCGATCGTGTTGCCCTTCGCGTCGACCATCGTCGATACCGCAGGCACTTGCCCCTCGAGCAGCTGGGCCGATCCGTTG GCAACGACCTCAGAGGCACGATTGGACATCAGCCCTAGCCCGCCTGCG :::::::::::::Rv279T7.seq::::::::::::: CCGTCGANGCCGCCGACTTGGCTTGACCGACACCAACATGGCCTGAGGGTGTTCAACAAGACCGTGGCCGACGGGCTGAACATCACCATGAGCGGCATGAGCCACG (SEQ ID NO. 332) CCACCGAGTTCATCATGTTGATCGCCGAAAACCATTGGCGGGTAGCGGAAGAACGGTCGAGGTGCTCTACACCGAGTATTCGAAGTCGAAAGGCCAACCGCTGCTC AACGGCGTCAACATCATTTTCGACGGGTTTCTGCGAGGGAGGATGCCACGATGAACTGGATCCAGGTGCTGTTGATCGCGTCGATCATCGGGTTGCTGTTCTACCT GTTGCGGTCGCGCCGAAGCGCGCGGTCCGTGCCTGGGTCAAGGTGGGCTATGTCTTGTTCGTGCTCCCGGCATCTATGCCGTGCTGAGA Clone Rv27 :::::::::::::Rv27SP6.seq::::::::::::: TTACACGNCCTGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGAC (SEQ ID NO. 333) ACTATAGAATACTCAAGCTTTTTGAGCGTCGCGCGGGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATNCGGATCTGACCGAAGTCGCTGCGGT GCAGCCCACCCTCATTGGCGATGGCGCCGACNATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGNGACGCGGTANGTGGTCAAGTCCGGTCTACNCTTGGG CCTTTGCGGACGGTCCCGACGCTGGTCGCGGTTGCGCCGCGGAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCACCGCCGCGGCACTGNACGGCCAGTGCCGC GGCGATGTCNGCCATCGGGACATCATGCTCGCGTTCATACTCCTCGACC :::::::::::::Rv27T7.seq::::::::::::: CAGGCATGCAAGCTTTGTCACACCAAGTGTTTCGACCAGGCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGT (SEQ ID NO. 334) TCAGCTCGCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCTGGCGCAGCTTGGGGATCGCGACGTCGATGGTTGCGGCACGGGTGTCGAAATCACGGT GGCGGTAGCCGTTGCGCTGATTGGACCGCTCATCGCTGCGTTCGCGGTAGCCCGCCCCGCACAGGGCGTCGGCTTCAGCCCCCATCAAGGCGG Clone Rv280 :::::::::::::Rv280SP6.seq::::::::::::: AGCTTAGCCAGTTTTTCTACTCTTGGGCCCACACCCACAGTGCTTCGACGGTACGGTCACCCATGATGGCCATCCAGTTGGCATCGGTGAGCTGATAAATGCCAGC (SEQ ID NO. 335) TGGTTTCGCCAACCCGGTAGCGATCTTGGCGCGCTGCTTGTTGTCACTGATACCTATCGAGCAAGACAGCCCGGTTTGCGACAAGATGACTTTTCGGATCTCTTCG GCGACTTCGATGGGGTCGTCGGGAGTCCCGGGCGCCACCGCGAGGTAAGCCTCGTCCCAGCCCCATACCTCGACCGGGTATCCCAGGTCGCGCAATAACGCCACCA CCTCCTCGGACGCCGCGTTGTAGGCGGCTGGGTTCGACGGCAAGAAGTGGCCTCAGGGCATCGTCGGCGCGGTCCCAACGGCNTGCCGGCGCGCACACCGTAGGCG CGGGGCTC :::::::::::::Rv280T7.seq::::::::::::: CCGGCGGAACTCAGACGTGCTGGTGGTGCGGCATGGCACCGCGGGCAGCAAAGCGCACTTCTCCGGGGACGACAGCAAGCGACCGCTAGACAAGAGGGGTCGTGCG (SEQ ID NO. 336) CAGGCAGAAGCGTTGGTACCACAGCTGCTGGCGTTCGGCGCCACCGATGTTTATGCCGCCGACCGGGTGCGCTGCCACCAGACGATGGAGCCACTCGCCGCGGAAC TGAACGTGACCATACACAACGAGCCCACCCTGACCGAAGAGTCCTACGCCAACAACCCCAAACGCGGCCGACACCGAGTGCTGCAGATCGTCGAGCAAGTAGGCAC ACCCGTGATCTGCACGCAGGGCAAGGTCATTCCCGATCTGATCACGTGGTGGTGCGAGCGCGACCGTGTGCCCCCGACAGTCCCGCAATCGCAAAGGCAGCACGTT GGTGT Clone Rv281 :::::::::::::Rv281SP6.seq::::::::::::: GTATGGTCAGCTGTCCATCCGGCGCTGTCGGCCGAGCTGCCAGATCTCGTCAGCCCGTAACCGGGTTGCGGGATCCACGCGTGCGGGTTGTCTAC (SEQ ID NO. 337) :::::::::::::Rv281T7.seq::::::::::::: CCGACTTTCCGCGGGTACCCGCTCAACTTTGTGTCNACCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGA (SEQ ID NO. 338) CGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATC GTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGCGACCCGGCCTATGGTTATTCGACCTCGCCGCCCAATGTTGC GACTCCGTTCGGTTGTTCCAGAANGTCAGCCCG Clone Rv282 :::::::::::::Rv282SP6.seq::::::::::::: GCACCGATGTCGGCGAGCACTTCGTCAACTTCCAGGGGTGCCCGCACCAAGTATTTCGACGAGTATTTCCGTCGGGCCGCCGCCGCCGGTGCGCGGCAGGTGGTCA (SEQ ID NO. 339) TCCTGGCGGCGGGGCTGGGACTCGCGCGCGTACCGGCTGCCTCGGC :::::::::::::Rv282T7.seq::::::::::::: TGCACCCAACTTACTGAGCATGCTAACGCTGGTCGTGCGGGTCTTGTTCCCGCGTGTCGGCAGGGCACACGCTCGGGGCGTAGCTGGGAGAGGCCCCGGTCAAGCC (SEQ ID NO. 340) CGGAGAGCAGTGCTCAGTCCGCCAGCTTGACCGACTTTCGATGAGAACGCGCTTCTCGCCGTATTGAACTGGCGTGCTGACGGTCGCTGAGCAGCGCTCGCCGAGT GCGGCCGCTGATTCTTTCATCGAGCCAGGACGCGCATTCGTGTTCGGCCGC Clone Rv283 :::::::::::::Rv283SP6.seq::::::::::::: AGCTTACGGCCGGTCGACGCGACGAGTGGTTCATGACACCACAAACCGTCAACGCCTACTACAACCCGGGGATGAACGAAATCGTCTTCCCGCAGCGATTTTACAG (SEQ ID NO. 341) CCACCATTTTTCGATCCGCAGGCCGACGAGGCCGCCAACTACGGCGGGATCGGGGCGCGTGATCGGGCACGATGATCGGGCACGGTTTCGACGATAGGGCGCCAAA TACGANGGCGACGCAATCTGGTCNATTGGTGGATCGA :::::::::::::Rv283T7.seq::::::::::::: ATGTCGTCACGTCACCACAATCGCGAGGACCCAATCATGCCGCCCAGGGCGGCCAACCCAATGGTGGCCGCGAAGCGGCAGCTCGATCGCAGCGCGGAGGTGCCGG (SEQ ID NO. 342) CCGCCAGTTGATTCACGAACAGGGTGAGGTCATAGGCGGGCAGGATAGTGACGAACGCAAGACCTATATCTGCCGTCGGAGTAAGAATCGAGTAGCCGGTCGACCA ACGGAAGCGAAAGTGTCCGCGATGTTGATGAGCGTCGCCGGTTGTGGCGGCGGTGGC Clone Rv284 :::::::::::::Rv284SP6.seq::::::::::::: AGCTTCACCAGCGTGCCGATGCTGTTCGCNACACCTCCCTACTATGCGCAATTCGCCGACACGGGTGGCATCAACACGGGCGATAAGGTGGACATCGCTGGGGTGA (SEQ ID NO. 343) ACGTCGGGCTGGTGCGCTCGCTGGCAATCCGCGGCAACCGCGTGTTGATCGGATTCTCGTTGCCCGGCAAGACAATCGGGATGCAAAGCCGGGCAGCAATTCGCAC CGACACCATTCTTGGCCGTAAGAACCTGGAAATCGAACCCCGCGGTTCGGAGCCGTTGAAACCCAACGGTTTCCTGCCGTTGGCGCAGAACACTACGCCATACCAA ATCTATGACGCGTTCGTC :::::::::::::Rv284T7.seq::::::::::::: CTGCCGCGGTGGCGGTCAGCGCCTGGCAAGTCACCGCACCGCCGTCCGGTTCATCGGCAGGCTCCCCCGAAAAGGGCCCTGGCAACAGAAGGTGATCAATGAGCTC (SEQ ID NO. 344) CCGCAGACCTTCGCCGATCTGGGACCGACATACGTGAAGTTCGGCCAGATCATCGCGTCCAGCCCGGGAGCATTCGGTGAGTCGCTGTCGCGGGGAATTCCGCGGC CTGCTCGACCGGGTGCCGCCCGCAAAAACCGACGAGGTGCACAAGCTCTTCGTCGAGGAACTCGGCGACGAGCCGGCCCGGCTGTTCGCCTCCTTCGAGGAAGAAC CGTTCGCGTCTGCGTCCATCGCCCAAGTGCACTACGCGACCTGCGCAGCGGCGAAGAAGTGTGGTCAAGATCCACGGCCGGGCATCCGCCGCCGCGTTT Clone Rv285 :::::::::::::Rv285SP6.seq::::::::::::: GATCGTGCCGGCCCCCCGGCGGCAGTAGCAGATCAGCTCGTCGAAATCGCAACAACCAGTCCAGTCGATTTCCATACGGGCGCCGTCAATCAACTCTGCGAACATC (SEQ ID NO. 345) GCGATCGGCACCGGAAACCGGCGAGCCGCGTCAGCCAGCGCAACCAGCACCGGGATCGGATGAATCATCAATATTATCAAGTGATTTCCTGATGGCATCGAGCTCG GTGATCTTGGTCTCGGGGGCCAGCTCGCCGTCGGCGACGTCGTCGATCCGGCGGCCGAGCGCATAGACCGCAAATAGTGCCGCTCGCTTTTCGCGCGGCAAGAGTC GGATGCCGTAATATANGTTTCTGGCGGCCGTGCGCGTGATCNACTCGGTGATTCGATACGCCTGTTCATCTCGGTCATGCCGTCCTC :::::::::::::Rv285T7.seq::::::::::::: GGTGGCGCAATGACCGAAACCACCCCAGCCCCGCAAACCCCGGCGGCCCCGGCCGGGCCCGCACAATCGTTCGTGTTGGAGCGGCCCATCCAGACCGTTGGGCGCC (SEQ ID NO. 346) GTAAGGAGGCCGTGGTACGAGTGCGGCTGGTGCCCGGCACCGGCAAGTTCGACCTCAACGGCCGCAGCTTGGAGGACTACTTCCCAAACAAGGTGCACCAGCAGTT GATCAAGGCACCCCTGGTCACCGTGGATCGGGTGGAAAGTTTCGACATCTTTGCCCACCTGGGCGGCGGCGGCCCGTCGGGTCATGGCCGGCGCGCTGCGCCTGGG TATCGCCCGGGCATTGATTCTNGTATCGCCGGATGACCGGCCCGCGCTGAATAANGCCGGCTTCTTGACCGTGATCCACGCGCCACCGAACGCAAA Clone Rv286 :::::::::::::Rv286SP6.seq::::::::::::: CACAATAGATTACTCAAGCTTCGAACCAGCGGCCTTATCACGTATCCCCGCTGAGACCTTGACCCTTAGGGCCGAAGTGACTTCGCTGCTGCTATGCCGACACCCG (SEQ ID NO. 347) ATTTCCAGACGCTGCTGTTACACGACGGCCGGGCCGGTGGCCACCATCACGCTCAACCGCCCGGAACAGCTCAACACCATCGTCCCGCCCATGCCCGACGAGATCG AGGCCGCTATCGGGTTGGCCGAGCGCGACCAGGACATCAAGGTCATCGTGCTGCGCGGTGCCGGCCGCGCCTTCTCCGGCGGTTACAACTTCGGCGGCGGGTTCCA ACATTGGGGGCAT :::::::::::::Rv286T7.seq::::::::::::: TCAGGACGCTTATGGTTGGCAGATGGTCGCCCTGGCGTCGAATACGCGCGAGCGCATGAGCTCACCGGTTCGGAACAACGTATCGAAGAACGTCGCACTGCTGGCA (SEQ ID NO. 348) GATGGTATCTCCGATGTGGTTGTAATTTGTATCCCAACTCTAACTGTGCTATCGGATCAGCGTGAATATCGAGATATTGCGAATGCGATGACAGGCCGCCATTCGG TTTATTCGCTTACGCTTCCCGGGTTCGATTCGTCTGATGCACTGCCGCAAAACGCGGATATGATTGTTGAAACCGTATCTAACGCAATTATTGATGTGGTAGGCGG CAGCTGCCGTTTTGTGCTGTCGGGCTATTCATCGGGTGGGGGTGTTTGGCTATGCCCTCTGCTCCCAT Clone Rv287 :::::::::::::Rv287SP6.seq::::::::::::: CGCAGCTGTCGCCGATCTGGTCCGGAATACCTAGCTCCAGGTTCTGAGTGGAGATGAGTGCGGCCATCGAAGTGTTGTCAATGTACTCCAGGATGTCAGGTGCCAG (SEQ ID NO. 349) GCCGCTGGCGAGGATCTTGGGCACCGCCGCCATGACTTGGTCGAAGTCGGCGAACGGGGCGAGCACGCTGGCGTCGTGGTC :::::::::::::Rv287T7.seq::::::::::::: GTAGTTCGTTCATCCAAACACAGTGCGGTACCGGCTCAAGCGGATCACCGACTTCACCGGGCGCGATCCCACCCAGCCACGCGATGCCTATGTCCTTCGGGTGGCG (SEQ ID NO. 350) GCCACCGTGGGTCAACTCAACTATCCGACGCCGCACTGAAGCATCGACAGCAATGCCGTGTCATAGATTCCCTCGCCGGTCAGAGGGGGTCCAGCAGGGGCCCCGG AAAAGATACCAGGGGCGCCGTCGGACCGA Clone Rv288 :::::::::::::Rv288SP6.seq::::::::::::: TCCGCTCGCTTCTCCGAGAGGTTGAGTGCCAACGCTCTGCCGATGCCCGAAGCCGGCCCCGGTGATGACGGCGACCTTGCCTTCGAATGAGCTCATTTGACTACTC (SEQ ID NO. 351) CCCGTGGTTGTCCCTGCGATTGGTGGAGGTGGCCGCGCAGCCTTGCCCCGAGGTCGGCGATCGCGTCTCGGGCTTCGGGGAGCAGACTGACCTGCAGATGGAAGTC GTGCCACATGCCCGCGAACCGGCGATGCTCGATGCTTGTTTTCGAAGCGGCGCAGGCGGTTTCGATCTTGTCCGCGTCAACACNGATCGGATCGTCGCCCGCGGTC TGCATGACGAATGGGCG :::::::::::::Rv288T7.seq::::::::::::: ATGGGAGGCCACCGATTACCATCTTGCACACACCGATTCCGGGCTATTGATGTCCACGTTCGGTCCGCGAACCGCGCTGTGGCTGCTGCTGGCCAAAGGCGGAGGC (SEQ ID NO. 352) GATACCGAAGTCAGTGCCCAAGCTTGGGTTCCACGCTCGCGCAGCCACGCCGTCACCTTTCCACGAGACCTCACCTGCCGATCCGAAATGGAATCGGCCGTGACGG AATTGGCGCAGCGAACACTCAACGAGGTGGTGGCTTCGTCGCGAACCGTCACCCGAGTCGCGGTCACCGTGCGCACGGCGACGTTCTACACCCGCACCAAGATCCG AAAGCTGCAAGCTCCCAGCACCGATCCCGACGTCATCACCGCTGCCGCCCGGCACGTTCTTGAACCTATTCGAGCTGGAATCGGCCGTCCGGTTGCTGGGAATTGC NGTTAAGAACTGGGCCT Clone Rv289 :::::::::::::Rv289SP6.seq::::::::::::: GCTTTGCGCGCTTCTCCGAGAGGTTGGAGTGCCAACGCTCTGCCGATGCCCGAGCCGGCCCCGGTGATGACGGCGACCTTGCCTTCGAATGAGCTCATTTGACTAC (SEQ ID NO. 353) TCCCCGTGGTTGTCCCTGCGATTGGTGGAGGTGGCCGCGCAGCCTTGCCCCGAGGTCGGCGATCGCGTCGCGGGCTTCGGGGAGCAAACTGACCTGCAGATGGAAG TCGTGCCACATGCCCGCGAACCGGCGATGCTCGATGCTTGTTTTCGAAGCGGCGCAGGCGGTTCGATCTTGTCCGCGTCAACGCAGATCGGATCGTCGCCCGCGGG TCTGCATGAAGAAT :::::::::::::Rv289T7.seq::::::::::::: CTCACGCAGCCACGCCGTCACCTTTCCACGAAGACCTCACCTGCCGATCCGAAATGGAATCGGCCGTGACGGAAATTGGCGCAGCGAAACACTCAACGAGGTGGTG (SEQ ID NO. 354) GCTTCGTCGCGAACCGTCACCCGAGTCGCGGTCACCGTGCGCACGGCGACGTTCTACACCCGCACCAACATCCGAAAGCTGCAAGCTCCCAGCACCGATCCCGACG TCATCACCGCTGCCGCCCGGCACGTTCTTGACCTATTCGAGCTGGATCGGCCCGTCCGGTTGCTGGGAGTGCGGTTAGAAACTGGCCTAGAAACCGGCGGGCACAC CGCACCTGGGCGGGGN Clone Rv28 :::::::::::::Rv28SP6.seq::::::::::::: TGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT (SEQ ID NO. 355) ACTCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGCCACCACNCGCGGGTCGGGCGCCGGGCCCGGGTCGCCANGCTGCTCCGCTCGGTGATGGCA CGCCACCGCGACACCACCCGGCTGCGCTACGTCGAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAAGTCGAAGTCGATA CCGATTGCGCATCCGCNGCCGCA :::::::::::::Rv28T7.seq::::::::::::: CAGGCATGCAAGCTTCACGTCCGTACGGCTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCTGCATCTTCCATAGCCCGCCAC (SEQ ID NO. 356) ACCTTCAGTTGCTCACCGGAATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAACCCTCGGGTCCGGCCA GCACTCCGCAGGCTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACC Clone Rv290 :::::::::::::Rv290SP6.seq::::::::::::: GCTTGTCTATCGTCCCGGCCAGGTCCGGCCAGTCAAGGTCGAAGGCCAGTCCGGTCTCCTCTCCGACTACGGCCAAGAACTGGGCGACGGTGTCAGTGCAGACCAG (SEQ ID NO. 357) CGGAAACTGGTGGCGCCCTAGGCGAGCGACCGCCTCACAAACGGCGGTGACCGCGTTCTGGTCGTGCACCATCGAGCCGTGCCCAGCCCGGCCGCGTGCCGTCAGC CGCATCCACTGGATGCCCTTCTCGGCGGTTTCAATCAGGTACAGGCGACGTTCGCCACCATCGTGCCGGGGCACGGTTAGCGAGAAACCGCCGACTTCACGATTGC CTCGGTGATGCCGTCGAAACAGATCGGGCCT :::::::::::::Rv290T7.seq::::::::::::: GCGCGCCATGTTGAGGTTGTCCGACGGTGACGACGGTGAACCACAACTGTTTGACCTGTCCGCACACACCGTGTGGATCGGCGAGCGGACCCGACAAATCGATGGC (SEQ ID NO. 358) GCGCACATCGCGTTTGCCCAGGTGATTGCTAATCCGGTCGGGGTCAAGTTGGGCCCCAACATGACCCCGGAACTGGCCGTGGAGTACGTCGAGCGGCTCGACCCGC ACAATAAGCCGGGCCGGCTGACTTGGTGAGCAGGATGGGCAACCACAAGGTCCGCGATCTGTTGCCACCGATCGTGGAGAACGTCCATGCCACCGGGCATCAGGTC ATCTGGC Clone Rv291 :::::::::::::Rv291SP6.seq::::::::::::: TTGCCTTCCATGCCGAGCAAGGTCGACTCAGCGATGACGAATTGTTCTTCTTCGCGGGTGTTGCTGCTGGTTGCGGGCTATGAGAGCACTGCTCATATGATTAGCA (SEQ ID NO. 359) CATTGTTTCTGACGCTGGCCGACTATCCAGATCAGCTGACACTCCTTGCGCAGCAACCAGACCTGATCCCGCCGGCGATCGAGGA :::::::::::::Rv291T7.seq::::::::::::: CGACGCTGGGCCCAACTGCGACCACCAGGTCCTGGTATGGCAGGACATGGCCGGGTTCAGCGGCGCCAATACCG (SEQ ID NO. 360) Clone Rv292 :::::::::::::Rv292SP6.seq::::::::::::: TAACGACTCGGGTCCAGCGACCGCGCCAACACNAACGGCCGGACNACGTGGGCCAGGGTCGCGGCCTCCCCTACAAACAGGATCCGTTGCCTGCGAACGACAGGCT (SEQ ID NO. 361) CCGGTGCGGCGTTGGGCGCCGTGCTCGTCCCAGCGTCCGGTCCCGGGTCGCCGGCGACGCTTGTTTCCTCCATACTCGCCCCCTAATCTCGAGGCAGCCCGTACCC GCAGGCAACCTCCCAAAAATGCAATCCCCCAAAATGCAATGCGTCNAGCTATTTCTCACACCGACCGCTAGTTGCGGATCANAAATCCGTTGGGCGCGGA :::::::::::::Rv292T7.seq::::::::::::: CNTGGCGGTGGGTGCGGTGTCGAACACGACCACACTTCTTTGCGGTTCGGTGATCTCGACACCGGCCGCGAGCCGACCACCATGCGCGCGTAGATCGGCGATCAGC (SEQ ID NO. 362) GCGTCGGCTATCGCCTGGGTGCCGCCCACCGGAATCGGCCAGCCGACCGAATGGGCCAGCGTTGCCATCATCAGTCCGGCGCCGGCCGACACCAGTGACGGCAACG GTGAAATCNCGTGGGCGGCAACGCCGGTGAACAACGCGCGGGCATCCTCGCCCGCCAGCGACCGCCAGGCAGGGGTGCCCTGGGCCAGCATCCGCAGCCCGAGACN CAGGACCGANCCCAGTG Clone Rv293 :::::::::::::Rv293SP6.seq::::::::::::: GCTTTTCNGATCGCAGCGAGTCGTACCCGCGCCGGTCACCTTCGTGGATATCGCCGGCCTGGTCAAGGGGGCGTCCGAGGGAGCCGGGCTGGGTAACAAGTTCCTG (SEQ ID NO. 363) GCTCATATCCGCGAATGCNACGCCATTTGTCAGGTGGTGCGGGTGTTCGTCAACAACNACTTGACTCATGTCACCGGACGGGTCGATCCCCANTCCGACATTGAGG TCGTCGANACCGAGCTGATCCTGGCANATCTGCAAACCCTGGAGCGGGCCACGGGCCGGCTGGAGAAGGAANCGCGCACCAACAAGGCGCGCAAGCCGGTCTACGA CGCGGCACTGCGTGCCCAGCAGGTGCTCGACGCCGGCAANACGCTGTTCGCCGCGGGGGTGGATGCCG :::::::::::::Rv293T7.seq::::::::::::: GTCGTACGCCATTNGTCGGTGTGCGCATACCAGTACGACGCGCCGGGCACCTGACGCGGCGGCCGCGACCAGTCGGTGGCCATCGCCATCGTCTGCCACCCGGTCA (SEQ ID NO. 364) ACGGACGCACCTTCTCCTGGCCGACGTAGTGCGCCCACCCGCCGCCGTTGCGTCCCATCNATCCGGTCAACATGAGCAGCGCCAACACCGAGCGGTACATGACATC GCTGTGGAACCAGTGACAGATTCCGCCGCCCATGATGATCATCGACCGTCCTCCGGATTCGGTCGCGTTGCGGGCGAAATTCCTTGGCAAACCGGATTGCCTGCGC GGCCGGCACACCGGTGATCGACTCCTGCCAGGCCGGGGTGTTCTGCTGGGTTCGGTCGTGGTACCGGT Clone Rv294 :::::::::::::Rv294SP6.seq::::::::::::: GCGAGGCGGTATCGCTTCCCGTCGTACCGGCGACCGCCAGCCGAGAAGCTCGTTTTCCCAGTGTTGCTGGGGATTCTCACGCTGCTGCTGCNTGCGTGCCANACCG (SEQ ID NO. 365) CTTCCGCTTCGGGTTACAACGAGCCGCGGGGCTACGATCGTGCGACGCTGAANTTGGTGTTCTCCATGGACTTGGGGATGTGCCTGAACCGGTTCACCTACNACTC CAAGCTGGCGCCGTCTCGTCCGCAGGTCGTTGCTTGCGATAGCCGGGAGGCCCGGATCCGCAATGACGGATTCCATGCCAACGCTCCGAGTTGCATGCGGATCGAA TACNAATTGATCACCCA :::::::::::::Rv294T7.seq::::::::::::: TGGGTCTTGCCGGCGAGCCCAGCGAAGTCGCTAGCGTGGCCGTGTTTCTTGGCTTCGGATCTATCCTCGTTACATGACCGGCACCGTGTTGGACGTGACTGGCGGC (SEQ ID NO. 366) CGGTTCATATGACACCGAGATCATTGCCACGGTACGGCAATTCGTCAAGAAGGAAATCTTTCCCNATGCACCGGCCCTCGAACGTGGCAACAGCTACCCGCAAGAA ATCGTCGATCGGCTGGGTGTTATTGGCTTGCTCGGTCGCCGGCTGCAAGGGTATCGACACCACCGAGTTCATTCTCGGGCGTGCCGGCGCATTCGAGCTGGCGGTG CGCGCTGCCCAGCACCGTCATAAGTACTTGANGATGGTCAAACGTCGGACGAACCGCCACCACGTCGCTGCCGAACGG Clone Rv295 :::::::::::::Rv295SP6.seq::::::::::::: TAGATGCCCAAGCTTGCCNTTANAGACCTCGTCGACCAAGCACGGACGCGACCGTCGAAGGTGGCGAATCCGGGCTTGGCGTCNACCCGCGTAAGGCAGACCAGAT (SEQ ID NO. 367) GGTTCGCGGCACGGTCAACCTGCCACACGGCACTGGTAAGACTGCCCGCGTCGCGGTATTCGCGGTTGGTGAAAAGGCCGATGCTGCCGTTGCCGCGGGGGCGGAT GTTGTCGGGAGTGACGATCTGATCGAGAGGATTCAGGGCGGCTGGCTGGA :::::::::::::Rv295T7.seq::::::::::::: TCTCCACGGCGTGGATCAAGGTACCGGCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGATGTCTGCGTTAGCGCCGGATTCCACCACATCCCCTTGCGA (SEQ ID NO. 368) AAAGTCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCTTGGC GTTGACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTNGGTAATCCGGCC Clone Rv296 :::::::::::::Rv296SP6.seq::::::::::::: GCCCGGTTCGATCGGGCATGTCCGCAGTCGTCGTTACCGGAGGCGGTCGTGGCCGCGCTAATCGGCGTCGGCGCCGACAAGATGTGGGATATCCGCAATCGGGGCG (SEQ ID NO. 369) TCATCCCTGCGGGCGCGCTCCCCCGCGTCCGAGCCTTCGTCGACGCAATCGAGGCAAGTCACGACGCGGATGAGGGGCAGCAGTGAATTACAGCGAGGTCGAGCTG TTGAGTCGCGCTCATCAACTGTTCGCCGGAAACAGTCGGCGACCGGGGTTGGATGCGGGCACCACACCCTACGGGGGATCTGCTGTCTCGGGCTGCCGACCTGAAT GTNGGTGCGGGCANCGCCGGTATCNACTCCCGTGGAACACAGCCGGGGC :::::::::::::Rv296T7.seq::::::::::::: CTCGGCGTGGATATCGGTGTAGCCGGCGCCGGTGAANGTCGGCTCCTTACGTCCACTCGACAACAGCTCATAGCGATCCAACCAGTANGCAACCGCCTTCAGCAGT (SEQ ID NO. 370) ACAACCGCGCCGGCGAACACTGCGAGTTGAACGCGAGCTGCCTGGGTCAGCATGCCTCTGCCGGTTGTCAGCCGAAGGCCGCCGAACAGGTAATGCGTCAACAGGC TCGCTAGAAACGCCAGAACCACGGCCACGAACAGCCAGTTCAGCACCGACCGGTAGAACGGCAGATCGAAGACGAAAAAACCCAATGTCATAGCCGAATTCGGGGT CCACGATGCCAAAGGTGCCCCCGTGTACAACAACTGAACCTTCACCCA Clone Rv29 :::::::::::::Rv29SP6.seq::::::::::::: TCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTC (SEQ ID NO. 371) AAGCTTCACGTCCGTACGGCTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGT TGCTCACCGGAATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGC AGGCTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCACGTAGACGGTTCCTTTCCTAAGCAACACCGAAGT TTCAGGACCGAATGCTCCGGGAAACATGTCA :::::::::::::Rv29T7.seq::::::::::::: CAGGCATGCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGCCACCACGCCCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGA (SEQ ID NO. 372) TGGCACGCCACCGCGACACCACCCGGCTGCGCTACGTCGAGCCATACCGGGCGGAGCTCCATCCGCTCGGCCGCCAGTGTCCGGGCCCTC Clone Rv2 :::::::::::::Rv2SP6.seq::::::::::::: CCTGCATCCGGCTCGTATGTTGTGTGGAATTGTGANCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGA (SEQ ID NO. 373) ATACTCAAGCTTCCAATCCCCCTGCCCTGATACGCGTCGGCAACCGTGAACGCGATCTCGGCGACCGTCGGATCGGTTTCATCCCGCACAAAACGCGCGTCGGCTA CGGGGTCGCTTCCGTCGGTCACCACCCAGACGAAGTGGTCGACGTAGTCGACTTCCGACAGGTAGTGCATCAACGCCGGACTGGGAACACNAGCCGACATGAACCG TCGATACAGCGTCTCNCCGGAGAACTGGATGTGTCCGTGCACGGTCCGCTCGCGGTCACCGGGCAGCACGGGGCGTAACATCAGTTGAGTCCCGTCGGCAAGCCGT ACCGGAATCGGGGAGACGA :::::::::::::Rv2T7.seq::::::::::::: CAAGATGATCGCCGGTGCCACCCCGATCCGTGCCTCGGTCAGCGCGAACGTGCTTTCCGGTCCGGCGACCACCATGTCGCACGCACCGACCAGGCCGAACCCGCCG (SEQ ID NO. 374) GCCCGCACATGCCCGTTGATGGCGCCGACCACCGGCAGCGGCGACTCGACGATGGCGCGCAACAGCGCCGTCATTTCCCGCGCCCGCGCCACCGCCATCCGGTACG GATCACCACCACCACCGCCGGCCTCGCTGAGGTCCGCGCCGGCGCAGAACGTTCCGCCGGTATGCCCCAGCACGACCAGCCGCACCGCCGGATCTGCTTCGGCCGC ACTCAGCCCTTGATGTAGTTGGCTGACCAGCGTGCTCGACAGCGCGTTGCGGTTGTGCGGAGAGTTCAGTGTCAGCCTGGCGAAGGGGCCGCCGCAGGCGGCCGGG CCAGCGTAGTCGACGGGGCTG Clone Rv301 :::::::::::::Rv301SP6.seq::::::::::::: CTCAAGCTTCGATCGACAGTACTCCCGCCTTGGGTCTGGTCTTCGAGCTGGTCGGTCATGGTCGGACCTGCTGGTAGTGGGGATCTAACGCAACATGGTCGGGATT (SEQ ID NO. 375) CATCATGGTGTACCCGTGATACCCATTCGCAGCTGCCGGTGAAACCCCGCGATGCCGGGATTTCCAGCCGCACTAGGATGTCTAGCCGGCCAGCCGCTGCCGCCGG ACTTCGGGATGTTCGGTATACCACCGATCGGCAATCTTGCNTATCCGCCGATGCTCGAACGCTAGCCACCCCAAACCAACCACTGTGACNACAATC :::::::::::::Rv301T7.seq::::::::::::: TGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGGGCGGATTGGCCCTGCCGCTGCAGCAGACCATCGACGCC (SEQ ID NO. 376) ATCGAATTGCCGGCAATCTCGTTCAGCCAATCCATACCCATCGACATTCCGCCGATCGACATCCCGGCCTCCACTATCAACGGAATTTCGATGTCGGAGGTCGTGC CGATCGATGTGTCCGTCGACATTCCGG Clone Rv302 :::::::::::::Rv302SP6.seq::::::::::::: TACTCAAGCTTGAACGCTGCGAGCGAGCCCATGTAGAGCGTTTGGTACCAAACCGATCGGTGGGCCAACTTGCCATGGGCTCACAGCGGCTATCGCGAGCGTGTAG (SEQ ID NO. 377) CCGATCATCGGCCAGGCGACGGTGGCCTGAGCGGCAGGGGTTGCCTTATCCATCCTCTTGCGGCATGGTTGCCGCAGGGAGTGCCGGTAAGTCTGGTCGGCAACCT GGCCCGCTGCGGGTTGGGTTCGGATTCCCTCGGCTAGTAAGGTGCTCGCCTGGTGTTACAACGAATCGCTAGACAGCTCTTATCGGGAGTGGCCGTCGCGATCGTT GCGCTGCCGCTGGCGATCGCGTTCGGCNTTACCGCCACCGGAACGTCCCAAGGTGCGCTCATCGGGCTCTACGGCGCCATCTTCGCCGGATTCTTCCCNGCCGTGT TCGGTGG :::::::::::::Rv302T7.seq::::::::::::: GCGGTGTCTGAACTTCGCCCGTTCCCTCCAGCGCATTGAGCTTCAGCCCGACCGGCAGGTAGGGAGTCGGCATGCGGTCCTTCGCCCCGACCCCGCTGGCTAAATA (SEQ ID NO. 378) GCCACCCCCGAGCGCGGTCACGGTCTTTGCACCGGGACGACGGCATACCGGCAGCGCGAACATCGCCGCGGGCTGCAGCGTGAACGTCGAATACGAGTCGAACAGT GTCGGCGCGTAAAAACCCGAGCCGGCGGTCGCTTCGGTAATCAACGGCTCCTGCGCAACCAGCTGCAANTCNCCGGTGCCACCGGCGTTGACAATCTTGATNTCGG CGACCTCGCGCACCAN Clone Rv303 :::::::::::::Rv303SP6.seq::::::::::::: TACTCAGCTTCGGCTCAGGTGGTGCTGCTGGTAAAGTTCNCTGAACGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGGTACTGCCATCGAGACACTGGCGC (SEQ ID NO. 379) AGGCTATCGCACCCGTTATCGGCTACAAACAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGAT CGCCGTCAAGCNTGTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCNTGTTTGGTCNCGATGCCTGGCGCCCGGCCGGCGT :::::::::::::Rv303T7.seq::::::::::::: CATCACCTGGTTCATGAAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCAGCTCGGC (SEQ ID NO. 380) CGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACANCGCGTTCTC CACCGACCGGGCCCGGGTGTGGGGTGTT Clone Rv304 :::::::::::::Rv304SP6.seq::::::::::::: CTCAAGCTTCCCGGCGGCCAGTACCGAAAGCGCGAACAGCTCGCGGCAGCCCACAACNTGCTGCGTCGGATTGCCGGCGGCGANATCAATTCCAGGCAGCTCCCGG (SEQ ID NO. 381) ACAATGCGGCTCTGCTGGCCCGCAACGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTG ATGCCCGGTCGGCAAGCCCGGCAGTTGCCAAACCCAGCGTGATCAGGCTCGGCTCGCGAGTTCGGCGAAGAAGTGGCTCGCCTGATCACCTACCATCGGCCAGGAT CTGCGTGTCATCACNACGCTCGCCAAGGAGGTTGTTGTGGTGCT :::::::::::::Rv304T7.seq::::::::::::: GCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACGACGCT (SEQ ID NO. 382) GATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGTCAATCACGTTGTCGCTTTCTACGGTCACCGACCCGGTGACCGTAGTC GCCCGGTGCGCTCGGCCGAGAAGTTGCACCGCCACCACCGCGACACCGTCTTGCACGCGGACGCCACCCCCGGATCGGTTGTTGGCCAAGGTAATTGGGTCATTCC ATTTGACGGGACGCCGACCCCGCAGCCCCAGTACCGCCCACGACCACGCCGGCTGACCCCACCACTGTACGAACACCAAGGCGACGCCGACCA Clone Rv306 :::::::::::::Rv306SP6.seq::::::::::::: CTCAAGCTTGATGCCGCCTAAACCGAAGCGTGAGCACGCCGCCACCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGATGGCA (SEQ ID NO. 383) CGCCACCGCGACACCACCCGGCTGCGCTACGTCAAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCNAGGTCNATA CCGATTTGCGCATCCGCAGCCGCACCCTGGACGACAGAACCGTGCCCTACGAGTGCTTGTCGGGCGGGGCCAAAGAACANCTTGGCATCCTGGCGCGATTGGCCGG CGCGGTCCTGGTC :::::::::::::Rv306T7.seq::::::::::::: CTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGGAATCCAACC (SEQ ID NO. 384) GGTANAANGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGCAGGCTTCGTCGGGGTGGTC GCGACNCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCG Clone Rv307 :::::::::::::Rv307SP6.seq::::::::::::: CTCAAGCTTCAATTCCTCCACGACGCGTTCCCAAATGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGGGCG (SEQ ID NO. 385) GATTGGCCCTGCCGCTGCAGCAAACCATCGACGCCATCGAATTGCCGGCAATCTCGTTCAGCCAATCCATACCCATCGACATTCCGCCGATCGACATCCCGGCCTC CACTATCAACGGAATTTCGATGTCGGAGGTCGTGCCGATCGATNTNTCCGTCNACATTCCGGNGGTCACCATCACCGGCACCAGNATCGACCCGATTCCGCTGAAC TTCGACGTTCTCAGCAGCGCCGGAACCA :::::::::::::Rv307T7.seq::::::::::::: TTAACCCCCGTGGCCTCTACGCCGCCTNCGGGTCGAACATGCATCCCGAGCANATGCTCGAGCGCGCACCCCACTCGCCGATGGCCGGAACCGGCTGGTTACCCGG (SEQ ID NO. 386) GTGGCGGCTGACGTTCGGCGGCGAGGACATCGGCTGGGAAGGGGCGCTTGCCACCGTCGTCGAAGACCCAGATTCGAAGGTGTTCGTCGTGCTCTACGACATGACC CCGGCGGACGAGAAGAACCTTGACCGGTGGGAAGGCTCCGAGTTCGGCATCCACCANAAGATCCGATGCCGCGTT Clone Rv308 :::::::::::::Rv308SP6.seq::::::::::::: CTCAAGCTTGATTTTGATCATCATGGATGATCATCACCCGAAGTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGGCT (SEQ ID NO. 387) TTCCGTATTGGTCTGGCAGGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGCTG CTGATTTCCCGGTTGAAAAANGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGACGGCTGCCGGCATGGTGTTCG CCGTTACCATGTCGTTGTTTGTGTTCAGCGATTTGCGAATTATTGGTCAGAT :::::::::::::Rv308T7.seq::::::::::::: CGNCCAACCCGAATTGGTTTTCGGCGCCNTCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCG (SEQ ID NO. 388) GTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCNCNGGCGTTACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTCGATGACG GCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCANACGACATCGTGGC GAGATTCGCCGG Clone Rv309 :::::::::::::Rv309SP6.seq::::::::::::: CGTGACTGCCACCGGGGCCACTCCGCAGAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTG (SEQ ID NO. 389) TCNACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACNCAGCGGTTCCNCTGACCAATACGGTCGGTC CCACGATGACCCANTACTACNTCATTCGCACGGANAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACC AAACTTGAAGGTGATTGTTAACCTGGGG :::::::::::::Rv309T7.seq::::::::::::: TCGCTCAAGCGCNTGAGGCCGAANCGGCTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACGCCCGACCAGCCGATGCTGGA (SEQ ID NO. 390) GGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCGACCCTGCTGGCAAAGATC ATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGAGCTGGAACACCGCCAGCTCGGCTTCGAGTTCGGCACTTTCA GTGACCGGTTCAACCGGCTCGAAAAGGCGCTACANAT Clone Rv30 :::::::::::::Rv30SP6.seq::::::::::::: ATACTCAAGCTTCCGCTGGGGCCTGTTCAACCATGGCGATCCCGTTGGTCCCGGACATCCCGAACGAGGACACCGCGACCCNCTTCGGTGTGTGATCATTACCGTT (SEQ ID NO. 391) GGGCCACTGCGTAACCGCTTGCGGCACAAAGAGCCCGGTCTCGACGTCGGAAAGCTCATCGGGCACCCGATTGAAATGCAGCAGCGGCGGCACCACCCCGTGCCGC AGTGACAGAATTGCCTTGATCAGCCCGACGGTCCCCGCCGATGCCGTGCTGTGCCCCATGTTGCTCTTGGCCGATCCAAGCGCGCAGGGGGTGCCCGCGCCATACA CCCGCGCCAGGCTGCGGTACTCAATCGGGTCGCCGATTGGCGTACCGGTGCCGTGCGCCTCCACCACACCGACCGTTTCGGGCTG :::::::::::::Rv30T7PEG.seq::::::::::::: CAACAGCGTTCCAGCGGCATACCACCGCACATGCCGTGCACCCGGCGCCGGGCGGAGTCGCCGCATAACACANGTACACCTTGGGAATCGGTGTGCGCCAGGGATT (SEQ ID NO. 392) CNACCGCGGGGTGGGGCCGGCGATCGCGCGCCAGGTCGAGTTGGCGCCGACCGTGATNTCACCGCCGACGTAGTTGGCGTTGTGGTCCGCCATCCGCGCGGCGGGC ACGGCGCGGGCCGCCACCACGATGTCACGGAAGCCGGGGGCGAACGCTCGACGACCTGGTTACCGTCTCNGTCGCNTCNANCGTGGACCCGACNGCACGTGGGCAT ATGTCCANAACGGACGNGGCCGGTTTCNTCGATGCNGCCGGGGTCCGCGACNTGCGGACNCNCNGNCACACCATCCGCCAGTCCGCGTGGCGTCCCGCCGCGACTC TGCCTCGGCCGCGCCA Clone Rv310 :::::::::::::Rv310SP6.seq::::::::::::: CTCAAGCTTTGNCGACGATCGGGCGATGTCGATGANAGGAAACCCCAGCGCACAACCGACNATTTTGGCGTAGCCGGCGGACNTCTGCTCGATTCCGATCACGTCG (SEQ ID NO. 393) GCGCTCGCATCGAGCATGGCGCCGGCGACGGCTAGCAGCGATCCGCCGTCGTCGAGGAACACGACACGAGCCGTACGCCCGGCCGTAAGCCGCGCCCAGGATTCGG CGAAAAACCGTTCTACGTGGCGGGTGTACTGGGTGTCCAATGATTCGTGGGGTGCGTAGGCGTCGCTGCAATCGTCGACATAAATGCCGTCGGCCCGCATCGCGTC AACAACTCCCGGGTGAGTGGAATANCACTTGCCGA :::::::::::::Rv310T7.seq::::::::::::: TCCAACGCGGTGACAGATTTGTCTATCCTGGACCTGACGGTGAGGTCGAAGTTTTCCAGGAATTCGGCAAAATCGGTAAGAGCCTGAAGAATTCGGTATCGCCGGA (SEQ ID NO. 394) CGAAATCTGCGACGCATACGGGGCAGATACGCTTCGGGTTTACGAGATGTCGATGGGGCCGCTGGAGGCTTCACGTCCATGGGCCACAAAGGATATTATCGGCGCG TACCGTTTTCTGCAGCGGGTGTGGCGCTTGGTCGTCGACGAGCACACCGGCGAAACTCGGGTGGCTGACGGCGTGGAACTCGACATCGATACGCTACGGGCGTTGC ACCGCACCATCGTCGGCGTGTC Clone Rv311 :::::::::::::Rv311SP6.seq::::::::::::: CTCGTCCTTGACTACGCCCAGTATCGAAANCCTCCTGTGCCGGTNCGCTAAACACCCGGCGGACACTCANACGGTGCTGGTGGTGCGGCATGGCACCGCGGGCAGC (SEQ ID NO. 395) AAAGCGCACTTCTCCGGGGACGACAGCAAGCGACCGCTAGACAAGAGGGGTCGTGCGCAGGCAGAAGCGTTGGTACCACAGCTGCTGGCGTTCGGCGCCACCGATG TTTATGCCGCCGACCGGGTGCGCTGCCACCANACNATGGAGCCACTCGCCGCGGAACTGAACGTGACCATACACAACGAGCCCNCCCTGACCGAAGAGTCCTACGC CAACAACCCCAAACGCGGCCGACACCGAGTGCTGCAGATCTTCG :::::::::::::Rv311T7.seq::::::::::::: GTATCGCCTCCNCCTTTGGCCACCAGCAGCCACAGCGCGGTTCGCGGACCGAACGTGGACATCAATAGCCCGGAATCGGTGTGTGCAAGTTGGTAAACGGTGTTGA (SEQ ID NO. 396) TCCCAAGCTTTGCCAGCCTTTTCGTAGTCTTGGGCCCCACACCCCACAGTGCTTCGACGGTACGGTCACCCATGATGGCCATCCAGTTGGCATCGGTGAGCTGATA GATGCCAGCTGGTTTCGCCAACCCGGTAGCGATCTTGGCGCGCTGCTTGTTGTCACTGATACCTATCGAGCAAGACAGCCCGGTTTGCGACAAGATGACTTTTCGG ATCTCTTCNGCGAACTTCCAATGGGGGTCTCCGGGANT Clone Rv312 :::::::::::::Rv312SP6.seq::::::::::::: CTCAAGCTTTTGGTCTAGCCGGCCGAGCACGATACGGGTGTCCTTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGANGANTGCT (SEQ ID NO. 397) GAACCGTAGTCGAAGTGGGCGGCGTCAGACTCCACCCAGCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGTTTG GGGCAATGACAGGTGGCGGCGGTGCGTTCGGGTCGGCCGGCGGAGGTGCTGCGTTGGGATCNCCCGGCTGGGCATTCGGCNTNTTGGCGGCGGCCGGTGGTGGGGG GGCAACANGTGTCCCGGTGCGGGTGGCGCTGC :::::::::::::Rv312T7.seq::::::::::::: ATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTA (SEQ ID NO. 398) CTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGC ACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCT ACGGCGACCCGGCCTATGGTTATTCGACCTCGCCGCC Clone Rv313 :::::::::::::Rv313SP6.seq::::::::::::: CTCAAGCTTGCAATGCGGGTCGGGATGCCCATGGTTGGAANATGGTCGCCCTGGCGTCNAATACGCGCGAGCGCATGAGCTCACCGGTTCGGAACAACGTATCGAA (SEQ ID NO. 399) AAACGTCGCACTGCTGGCAGATGGTATCTCCGATGTGGTTGTAATTTGTATCCCAACTCTAACTGTGCTATCGGATCAGCGTGAATATCGANATATTGCGAATGCG ATGACAGGCCGCCATTCGGTTTATTCGCTTACGCTTCCCGGGTTCGATTCGTCTGATGCACTGCCGCAAAACGCGGATATGATTGTTGAAACCGTATCTAACGCAA TTATTGATGTGGTAGGCGGCAGCTGCCGTTTTGTGCTGTCGG :::::::::::::Rv313T7.seq::::::::::::: CAAATACACGCCGGACGCACAGGCGGACATCGCCATCCCGAGCACACCCAAAACGGGATACAGGATGGAGGCCAACGCCACGGCCGCGCCCAGGATCACCAACCAC (SEQ ID NO. 400) ACCGGCTTGGTCAGCTTGTCGGCGGCGGTATAGGCATCGGGCCGCTGCAACGCAGCATGCACAAACGCGTACACCGCTGTCACCAAGACGGCGACCAGCAATACCA GCATGACGGTACCCACGAGGTGGCTCACGCATTCAGACTATGCGGTTTGCATCCAACACG Clone Rv314 :::::::::::::Rv314SP6.seq::::::::::::: CTCGTCCTTCGGCCTCGCTGCAGGAGTGGGAGCCGCAGGGCTGGAAATCCGAAAAACGAGCCGGTGATCGCACTGTCGCCGATCGGCGCCGCACCTGGTTGGTGTT (SEQ ID NO. 401) ACGGATGAATCCGCAGCGAAATGTGGCTGCGGTGGCGTGTCGTGACTCGTTGGCGTCGACGCTGGTGGCAGCCACCGAGCGGTTGGTCCAGGATCTGGATGGGCAA AGTTGTGCGGCCCGGCCGGTGACGGCCGATGAGCTGACCGAGGTCGACAGCGCCGTGTTGGCTGACTTGGAACCGACATGGAGTCGCCCCGGTT :::::::::::::Rv314T7.seq::::::::::::: GTCTAGNCCGCCGAACACGATACGGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGAAGANTGCTGAACCGTAGTCG (SEQ ID NO. 402) AAGTGGGCGGCGTCAGACTCCACCCAGCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGTTTGGGGCAATGACAG GTGGCGGCGGTGCGTTCGGGTCGGCCGGCGGAAGTGCTGCGTTGGGATCGCCCGGCTGGGCATTCGGCGTGTTGGCGGCGGCCGGTGG Clone Rv315 :::::::::::::Rv315SP6.seq::::::::::::: ACTCAAGCTTGAGATTGGCGTCAACGGGTGTCGGCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCTCGTGGCCACGCA (SEQ ID NO. 403) TGTACANCACCACGCCGCGCCCCTCACGGGCGACCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGCGTGACCCAAACACATCGCCGGTCAAGCA CTCCGAATGCACCCGGACCAGCACGTCG TCACCGTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAGCGCGACATGTTCCACGTCCTCGTAAATGCTGGTGTANCCGATGGCGCGAAACTCCCCATGACAAN TCGGAATCCCGCGCCTCGGCGACCCCGCTCAATGTTGCTTCTCNTGCTTG :::::::::::::Rv315T7.seq::::::::::::: TCGACNAGCATTCTTGACNGTTGTTTTGGCTCGGCATGGTTAGCCAAGGTTCTGCGGTCCCACCAGATCATCTTGGTCCGGTAGCGCTCGTCCGGGTATGCTGCCG (SEQ ID NO. 404) CCGGGATTCTCGCTGCTATTACTCCCCCCGAAGAACGCCACCGGTCCAGCGCGTGGGCCGCCGCGGTCCCCATCACAAACTGAACCCCCAACAGGGGACATGCTTA GCGGTAGGGCGCGCGCCAAGGCGGCAGCAATCGCATCACTGCGCTGCGCGTCACTATTAACCCAGCCGGACTTCACTTCCACGACCCCGAATGGCGCCCGGTCATT GATCATCTTGCGCACCGCGGATAATCCGGGAT TG Clone Rv316 :::::::::::::Rv316SP6.seq::::::::::::: ACCGGGGCCACTCCGCACAATCTGTACCCGACCAANATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCNACCCTCA (SEQ ID NO. 405) ACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCNGCGGTTCCGCTGACCAATACGGTCGGTCCCACNATGAC CCANTACTACATCATTCGCACGGANAACCTGCCGCTGCTAAAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAG GTNATTGTTNACCTGGGCTACGGCGANCCGGCCTNTGGTTATTCCACCTCNCCGCCCAATGTTTGCNACTCCCGTTCGGGGTTGTTCCCNNAAGGTCAACCC :::::::::::::Rv316T7.seq::::::::::::: CGCTCAAGCGCNTGAGGCCGAANCGGCTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACGCCCGACCAGCCGATGCTGGAG (SEQ ID NO. 406) GCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCGACCCTGCTGGCAAAGATCA TCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGANCTGGAACACCGCCAGCTCGGCTTCGAGTTCGGCACTTTCAG TGACCGGTTC Clone Rv317 :::::::::::::Rv317SP6.seq::::::::::::: CTCAAGCTTGCGTTCGATGAAGTAGTCGTCGGTCAGCGCCGCCTCTTCGAGCTCCTTGGCGATGCCCAGCAAGGAGTCATCGCCGCCGAGCTTGGCCAGGATCTTG (SEQ ID NO. 407) TCGGCCTGTTCCTTGACGATGCGGGCCCGCGGATCGTAGTTCTTGTAGACACGATGACCGAAACCCATCAATTTGACCCCGGCCTCGCGGTTCTTGACCTTGCGTA CAAACTCGCTGACGTCGTCGCCGCTGTCGCGAATGCCCTCGAGCATCTCCAGGACAGCCTGATTGGCGCCGCCATGAAGCGGACCCCATAGTGCGTTGATGCC :::::::::::::Rv317T7.seq::::::::::::: GGTCAGGCCGAGCAGGCGCGAGGAACGACGAACCCAACAAGCCATGGTGGTTGGCGCCGTCGAGAGGTCGGCGGTCGCCACAACGGGAAGATCGCCTTGAGCGTCG (SEQ ID NO. 408) CTCGACCGCCGCCTCGAGTTGGGTCATAACGAAGTAGCTGATGCCGATCATGTCGACGTTTCCGTCGCATCAGCGTGCAGCGGCGACCCACTCNACGAGGTCTCGG TGCCGCCGCGGCCAGGGCACCAGCAGTGACGAGTCCAGGCGCCGTCGGGCCAAGCAGTCGCGGTGCCANCCGTGGTGGGTCGGGCGATGGTTGGGTGTGCTCATTT CGGGAACGCCA Clone Rv318 :::::::::::::Rv318SP6.seq::::::::::::: CTCGAAGCTTTTAACAGCATCAACCCCGCCCCGCACCAGCACCGACACNATGTCGATGCCATCGAGGTGAATGTCGAACTGGCGCAAACCATCGGCGACCGCGACCA (SEQ ID NO. 409) CCGGCAACATGGGTACCGGCGATTTCCGGTGCCAATGCCGACCCGACGGGCCGCTCTCACCGCAGGTGACCTCGATCACCGAGACCANCCGGCCGTTNTNNTCACG CACCCCTACCGTGTCACGCCCAAAACGGCGCTGGTGGTCGATTGCCGGAGTGCACCCCNCACCCAGTGTCGTGCCCGGATCC :::::::::::::Rv318T7.seq::::::::::::: TGATGCCGCACCCGATCGACGGTCGTTGGTCGGGGTTGACTGGCCGCCCGGCGAAGCAGGGCGTCGACCGCGGCCCGGACGTCGGCGGCCGTCACCGGTCGGCCAT (SEQ ID NO. 410) TGCCCGGGCGGGAGTCGTCGAGCTGACCACGGTAGACAAGTCGGCGCTGGCCGTCGAAGACNAACGTGTCGGGTGTGCAGGCCGCGGAGAAGGCGCGGGCGACNTC TTGGGTTTCGTCGTANAGATACGGGAACGTCCAGCCGTGGCGGCGGGCCTCGGCGACCATCTGATCGGGCCCGTCC Clone Rv319 :::::::::::::Rv319SP6.seq::::::::::::: TTTCGGGCGAGGCGGTATANCTTCCCNTCGTACCGGCGACCGCCAGCCGANAAGCTCGTTTTCCCAGTGTTGCTGGGGATTCTCACGCTGCTGCTGANTGCGTGCC (SEQ ID NO. 411) AAACCGCTTCCGCTTCGGGTTACAACGAGCCGCGGGGCTACNATCGTGCGACGCTGAAGTTGGTGTTCTCCATGGACTTGGGGATGTGCCTGAACCGGTTCACCTA CNACTCCAAGCTGGCGCCGTCTCGTCCGCAGGTCGTTGCTTGCGATAGCCGGGAGGCCCGGATCCGCAATGACGGATTCCNTGCCANCGCTCCGAGTTGCNTGCGG ATCGACTACNAATTGATCACCCANAACCATCGGGCGTNTTACTGCCTGAAGTACCTGGTGCGGGTCGGATACTGCTATCCGGCGGTGACAACCCCGGCAAGC :::::::::::::Rv319T7.seq::::::::::::: GTTTTGGCTCGGCATGGTTAGCCAAGGTTCTGCGGTCCCACCAGATCATCTTGGTCCGGTAGCGCTCGTCCGGGTATGCTGCCGCCGGGATTCTCGCTGCTATTAC (SEQ ID NO. 412) TCCCCCCGAAGAACGCCACCGGTCCAGCGCGTGGGCCGCCGCGGTCCCCATCACAAACTGAACCCCCAACAGGGACATGCTTAGCGGTAGGGCGCGCGCCAAGGCG GCAGCAATCGCATCACTGCGCTGCGCGTCACTATTAACCCACCCGGACTTCACTTCCACGACCCCGAATGGCGCCCGGTCATTGATCATCTTGCGCACCGCGGATA ATCCGGGATTGCCAGCCCATTCNACTACCGCATGCGAGTCATCGGCTGACCGCAGCGGTC Clone Rv31 :::::::::::::Rv31SP6.seq::::::::::::: TCGCCTAGGCGGGCTTCCCCTTCCGTCCGAGCNGTCAGAAGCTCCTATGACAATGCACTACCCGAGACNATCAACGGCCTATGCAATACCNAGCTGATCAAACCCG (SEQ ID NO. 413) GCAAGCCCTGGCGGTCCATCGAGGATGTCGAGTTGGCCACCGCGCGCTGGGTCGACTGGTTCAACCATCGCCGCCTCTACCGGTACTGCGGCGACATCCCGCCGGT CTAACTCGACGCCGCCTCACTACGCTCAACGCCAGAGACCANCCGCCGGCTGACGTCTCAGATCAGAGAGTCTCCGGACTCACCGGGGCGGTTCATCCCCACTGTC GATAGCGTCTGTGGATAACTTTGTCTGCA :::::::::::::Rv31T7.seq:::::::::::::: GCGCGTNGAACTGATAGGTGCGGCCCGGCTCGAGCANGCCGGCCATTTGTTCGATGCGGTTACCGAAGATCTCTTCGGTGACCTGCCCGCCGCCGGCCAGCTCGGC (SEQ ID NO. 414) CCAGTGCCCGGCGTTGGCCGCCGCGGCGACAATCTTGGCGTCCACGGTGGTCTGGGTCA Clone Rv321 :::::::::::::Rv321SP6.seq::::::::::::: CTCAAGCTTCAATACAGAGTTATAAACTGTGATAATCAACCCTCATCAATGATGACNAACTAACCCCCGATATCAGGTCACATGACGAAGGGAAAGAGAAGGAAAT (SEQ ID NO. 415) CAACTGTGACAAACTGCCCTCAAATTTGGCTTCCTTAAAAATTACAGTTCAAAAAGTATGAGAAAATCCATGCAGGCTGAAGGAAACAGCAATAACTGTGACAAAT TACCCTCAGTAGGTCAGAACAAATGTGACGAACCACCCTCAAATCTGTGACAGATAACCCTCAGACTATCCTGTCGTCATGGAAGTGATATCGCGGAAGGAAAAT Clone Rv322 :::::::::::::Rv322SP6.seq::::::::::::: CTCAAGCTTCGATCGACATTACTCCCGCCTTGGGTCTGGTCTCCGAGCTGGTCGGTCATGGTCGGACCTGCTGGTAGTGGGGATCTAACGCAACATGGTCGGGATT (SEQ ID NO. 416) CATCATGGTGTACCCGTGATACCCATTCGCAGCTGCCGGTGAAACCCCGCGATGCCGGGATTTCCAGCCGCACTAGGATGTCTAGCCGGCCAGCCGCTGCCGCCGG ACTTCGGGATGTTCGGTATACCANCGATCGGCAATCTTGCGTATCCGCCGATGCTCGAACGCTANCCACGCCAAACCAACCACTGTGACNACAATCGCCACCACAC CAAAGGTCATGCCCTCGGCGTGATGTCCGGTGCCGAAAGCCGCAAGAGCTCCGACGCCGCC :::::::::::::Rv322T7.seq::::::::::::: CATTCCCAATTGAATTTCCCNATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGGGCGGATTGGCCCTGCCGCTGCAGCANAC (SEQ ID NO. 417) CATCGACGCCATCGAATTGCCGGCAATCTCGTTCAGCCAATCCATACCCATCGACATTCCGCCGATCGACATCCCGGCCTCCACTATCAACGGAATTTCGATGTCG GAGGTCGTGCCGATCGATGTGTCCGTCGACATTCCGGCGGTCACCATCACCGGCACCAGGATCGACCCGATTCCGCTGAACTTCGACGTTCTCAGCAGCGCCGGAC CCATCAACATCTCGATCATCGACATTCCGGCGCTGCCGGGCTTTGGCAACTCGACCGAGCTGCCGTCGTCGGGCTTCTTCAACACCGGCGGCGGTGGCGGCT Clone Rv327 :::::::::::::Rv327SP6.seq:::::::::::::: CTCAAGCTTTCGGCGGAGACGGACANNTTGCGAACATTGATGACAAAATAGAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAAATTC (SEQ ID NO. 418) CAATCAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCCGTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATATGGC GAAAAACGGTCGCCGTTGCACGACATTAAATGTCACGGTATTG :::::::::::::Rv327T7.seq::::::::::::: AGCTTAACTGCTCCCTAATACCTGGGGCTGTGCCTGCGGTGTATGCACGGCATACGGACATCCNTCCCCTGAGACCCNCGGTCTAATCAGCCACGTGTCCACCATC (SEQ ID NO. 419) AGGGGTCAACCCCGGCCAAGGGCGACGGCACCCCAAGTTCGCCGACCGTTAACCTATTGCTGTGAGCTTCATTTGCTGCGAGCAAAACAGTTGGTCGGCCGTTAGG AACTGAATTGACACTCAACCGATTTGGTGCCNCCGTAGGTGTCCTGGCTGCGGGTGCGCTGGTGTTGTCCGCGTGTGGTAACGACCACAATGTGACCGGGGGAGGT GCAACCACTGGCCACGCGTCCGCGAATGTCTATTGCGGGGG Clone Rv328 :::::::::::::Rv328SP6.seq::::::::::::: CTCAAGCTTGGGGTGGCGCTGTCGGTCGGTGTGCTTGGCGGCGTCGGTATCAACACCGCCCACGAAATGGGGCACAAGAAGGATTCGCTGGAGCGGTGGCTGTCCA (SEQ ID NO. 420) AAATCACCCTCGCCCAGACCTGCTACGGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCCGGGTGTCCACACCGGAGGACCCGGCGTCGGCGCGGTTCGG CGAAACGTTGTGGGAGTTCCTGCCCCGCAGTGTTATCGGCGGCTTGCGCTCGGCCGTTCATTTGGAGGCCCAACGGCTGCGTCGGCTCGGCGTCAGCCCCCT :::::::::::::Rv328T7.seq::::::::::::: GCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGCGCCGACCCCGCCCGAGGTCCTGGCCGTTACCACCTGAACGGGCGAGCCGGGAGTCTGGTACGCATCGAA (SEQ ID NO. 421) CAAAGAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGGTCNATCCATTCGAGGTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCAG GTACTCGACCTCACAGACGAGAGGACTCGATCCCATCTAGGTGTGGACGAAACAGATCTTCTGTCCGA Clone Rv329 :::::::::::::Rv329SP6.seq::::::::::::: TCGCCTCCGCATATGGGTCGACGCCAAGCGGGTCCGGATTTCTGGGCTTCATCGCTCGCGCCGTCGCGACAAACAGCGCGGTCGAACCGACACTCGTTGTGATGTC (SEQ ID NO. 422) CCAGCTATCACCTTCGGTACGCACCCAATCGACCCTACNCGGCTATCTCAGCCGCGATCTCCAGGCTCCGCCGAGCCAGGTGCATCCCGGTCCGGATCCCACTAAC CCGGCACCATTGGCGTCN :::::::::::::Rv329T7.seq::::::::::::: GTCCTCGAGTGCCGCCGTCGNCACNCCCAGCGCCCGCGCGGCCACTTGGATGCGACCCGTTTCAAGTCCCTTCATCATCTGCGAAAAGCCTTGACCCATGGCTCCG (SEQ ID NO. 423) CCCAGGATCGCCGAGACCGGCACCCGGAGGTTGTCGAACGACAGCTCGCAGGATTCGACGCCCTTGTAACCCAACTTCGGCAAGTCCCGCGACACCGTGAGTCCCG GCCCGGGTTCGACGAGCACGATCGACATGCCTTGGTGCCGCGGTGTGGCGTTCGGGTCGG Clone Rv32 :::::::::::::Rv32SP6.seq::::::::::::: GGCATACCAATGTGGACTTCTGCTCACCCACGATATCCGTGGTCTGATCCGCTGCTGCGGCGGGCTGCNACCTGCNTCTCNGCGGCACCCGTNACTACATGGCNCG (SEQ ID NO. 424) CGCCGCACGCATACGTCGCGGCGGGACCCACTCCNACTGGTCGACGGTGCTGGCCGCGTGTCCGCANGTCCCNAACCCGGCCGCACCGACGAAACCGGCCGCCGTC CGTTCTGGACCAACGCTCATGTGCCGTCGGGGTCCATGCTCGACGCCATCGAGACCGTAACCAGCGTCCTCGAGCGGTTCGCCTCCGGCTTCCGTGACATCTTCGT GGCTGCTCGCGCCGTGCCGCCGCGCGGATGGTCGACCACAACGCCAACCACCTCGGCGGTGACATCACCGTCCGCGCCACTCGACCTGGCGCGCGATCGCGGCCC :::::::::::::Rv32T7.seq::::::::::::: GTGAGCAGACCTACGCCNCCTGGTTGCGCCAACTCGGTACCGATCATGGCGCGCNGCCTGTCGTCACCGATACCCAGCGAACAAGACAGCCCGGTCCGCGACAAGA (SEQ ID NO. 425) TGACTTTCCCGATCTCTTCGGCGACTTCCATGGGGTCGTCCGGAGTCCCGGGCGCCACCGCGAGGTAACCCTCGTCTCAGTCCCATACGCGACCGGGTATCCACGT CGCGCAACAACGCCACCACCTCCCCAGACGCCNCGTTGTACGCGGCTGGGTTCCACNGCAATAAGTGGCCTCANGGCATCGTCCGGCGGCGGTCCNCAACGCA Clone Rv330 :::::::::::::Rv330SP6.seq::::::::::::: CTCAAGCTTGAGGTTAACTTTGAACGGATCGAGCTGGACGTTCGAGACGGTGATCGGGCCGAACCTGAATTGTCCGGTAATGCCCAACGCAAAAAGCAGGGTGGTG (SEQ ID NO. 426) GCCGGGGCGGTGAAACCGGCGTCGGCGGCACCGTCGAAATCTATGTGGATTGCCGGAATGGGGATGTCCGGCACGGCGAAACCGTAGTTCGCTTGTCCCGTGAGGC CCAGGTGGATGGGGGGAAAGATCCTGGTGTCCGGGATAATAATGGGGCCGATGCCGCCGGTTGAAGTCCACTGGATCGGGAATTCCGGAATCTTGATCCGACGTTC AGGCCGAACAGGCCCTC :::::::::::::Rv330T7.seq::::::::::::: CGGCGACGTCGCGATACGCCGAGCAGTTGGGAATCGCTCTGCAGCAAACCAATATTCTGCGCGACGTTCGAGAGGACTTTTTGAATGGACGGATCTACCTGCCGCG (SEQ ID NO. 427) CGACGAGCTGGACCGATTAGGCGTACGCCTCCGCCTGGACGACACCGGGGCACTCGATGACCCCGACGGACGGCTCGCGGCNCTGCTGCGGTTCAGTGCCGACCGC GCCGCAGACTGGTNTTCGCTGGGACTGCGGCTGATTCCACACCTCGACCGCCGCAGCGCTGCCTGCTGTGCGGCCATGTCTGGCATCTACCGCCGTCAGCTCGCCT TGATCAGAGCATCGCCGGCGGTCGTCTA Clone Rv331 :::::::::::::Rv331SP6.seq::::::::::::: CTATAAAATACTCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCG (SEQ ID NO. 428) GTGATGGCACGCCACCGCGACACCACCCGGNTGCGCTACGTCNAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCN AGGTCNATACCGATTTGCGCATCCGCAGCCGCACCCTGAACNACANAACCGTGCCCTACTATTGCTTGTCNGGCGGGGCCAAAAAACAGCTTGGCATCCTGGCCCN ATTGGCCGGCGCGG :::::::::::::Rv331T7.seq::::::::::::: CTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGGAATCCAACCGGTAGAAGGT (SEQ ID NO. 429) CGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGCAGGCTTCGTCGGGGTGGTCGCGACGCGCA TGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCNCCANCACGTANACNGTTCCTTTCCTAA Clone Rv333 :::::::::::::Rv333SP6.seq::::::::::::: CTGGCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGCGCCGACCCCGCCCGAGGTCCTGGCCGTTACCACCGAACGGGCGAGCCGGGAGTCTGGTNCGCATCG (SEQ ID NO. 430) AACAAANAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGGTCNATCCATTCGAGGTCCGTCGCCGCGTCGGTCNAGTGGCGGTCACACTCC AGGTACTCGACCTCACAGACNAAAGGACTCNATCCCATCTAGGTGTGGACNAAACAGATCTTCTGTCCGACNACTACACCACCACCCAGGCCATCGCCGCCGCCCG CGATGCCAACTTCGACGCCGTACTGGCCCCGGCGGGGGGCGCTCCCCGGTTGTCAACACTTGCCGTGTTCNTTCACGCNCTGCCCCACATCCAACCCCAACG Clone Rv334 :::::::::::::Rv334T7.seq::::::::::::: GTTCTTGGGCCCATGCGGAGGTATCGCCGTTTCCACCACGCGGTCGGGGTGGCGTTGCATTAGCTCACCGATGGTGCGCTTGTGCAGGCCGCCGGGATACCCCGAG (SEQ ID NO. 431) TGCCGGTAAACCATCTTGTGCTGC Clone Rv335 :::::::::::::Rv335SP6.seq::::::::::::: CAATACTCAAGCTTGGCGTGCCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACNAGNACGTCGTCCGCGGGACACACCT (SEQ ID NO. 432) CGATGCTGCCGCCATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGG ATC :::::::::::::Rv335T7.seq::::::::::::: CNTCATGATGATCATCACCCGAAGTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGGCTTTCCGTATTGGTCTGGCAG (SEQ ID NO. 433) GACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGCTGCTGATTTCCCGGTTGAAAG AGGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGACGGCTGCCGGCATGGTGTTCGCCGTTACCATGTCGTTGTT TGTGTTCAGCGATTTGCGAATTATTGGTCAGATCGGTACCAC Clone Rv336 :::::::::::::Rv336SP6.seq::::::::::::: ATACTCAAGCTTTTACGGTGATCGCNCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCG (SEQ ID NO. 434) GGTGCAGGTGCTCGGGCAGCTCGGCCGCNACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGANNAACGACGCCAGTCCGCTACGTNACCCCTCCGCGAC TGTCCATGGACAACAGCGCGTTCTCCACCGACCGGGCCCGGGTGTGGGGTNTT :::::::::::::Rv336T7.seq::::::::::::: GCTGGTAGAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTTATCGGCTAC (SEQ ID NO. 435) GAGCAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCAAGCATGTGTGCCGCGGAT TATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCG Clone Rv337 :::::::::::::Rv337SP6.seq::::::::::::: GCTTTCCGCCGATACCCGCCATGTCNCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGCGGATGATCGGGCCGCCTACGTCGTG (SEQ ID NO. 436) GTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAAGGCCTATGTCA CCGGTCCGGCANCACTCAATGCCGACCAGGCCGAGGCCGGANACAAAANTATCGCTAAGGTCACCGCGATCACNAGCATGGTGATCGCAGCAATGTTGCTAGTGAT CTATCGCTCCGTAATTA :::::::::::::Rv337T7.seq::::::::::::: CTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCG (SEQ ID NO. 437) GTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTCGATGACG GCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCANGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCA Clone Rv338 :::::::::::::Rv338SP6.seq::::::::::::: TACTCAAGCTTCGCGAGATCCGGATGGCACTCACGCTGGACAAGACCTTCACAAAATCTGAAATCCTGACCCGATACTTGAACCTGGTCTCGTTCGGCAATAACTC (SEQ ID NO. 438) GTTCGGCGTGCAGGACGCGGCGCAAACGTNCTTCGGCATCAACGCGTCCGANCTGAATTGGCAGCAAGCGGCGCTGCTGGCCGGCATGGTGCAATCNACCAGCACG CTCAACCCGTA :::::::::::::Rv338T7.seq::::::::::::: CCCACGACTTTCTCCTCGATCAGTTGGATTTGTACGAAGAGGCAACGAAAGCAGTGATCCTCGGGATGGTCGACGCCTACATCGACCCGCCGTTCACGCCGCACAG (SEQ ID NO. 439) CCTGCTAGATGCGCTGGGCGAGCAGGTCCCACAGTTCGCCGCTAAGGCACGGCGTCTGTTCCCGTCCGGATCGCCATTCGGCCTCGGCGTCCTGCTCCCATTCGAT CAATAGGGCTGGCAGCTCCGTCGGCAGGGGCCTACGCCTCACCCCGTCACG Clone Rv339 :::::::::::::Rv339SP6.seq::::::::::::: CTCAAGCTTATGCGCGCCGGCCGAGGTCTGCTCACGGCAACCCCTGAAGTTTAGGGGACNACCTACTCAGCGCAAAATTTCGCTAATGTGAGTCCGCCCCACCAGG (SEQ ID NO. 440) GGNANATCAACCCATGTCGATCATGATCTACCCGGATACCGGATTGGCGGTAGCGCCCACGATCGTCNAAATNTCCGCCTGAATCATCGGATAGCTGATCCGGCGT CAACGCGTTTTGANTTCACCGCGCAACAGCCGCCAGGCCGGCCCGCANCGANCCGATCTCNTCGGGCCGCATGGGCCCCAATCTTNTCG :::::::::::::Rv339T7.seq::::::::::::: GTGTGTGGTGGAACCCATCTGAGCAGTGTGCCAAACCGGGGCAGACAGCTCCCAATTGACGTGAGCCCGCTCACTTGCTGGGTAAGCGTC (SEQ ID NO. 441) Clone Rv33 :::::::::::::Rv33SP6.seq::::::::::::: CTTTACACTTCCTGCATCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTG (SEQ ID NO. 442) ACACTATAGAATACTCAAGCTTGGGCGTGACGGCCACCGGGGCCACTCCGCACCATCTGTACCCGACCAAGATCTAC :::::::::::::Rv33T7.seq::::::::::::: CAGGCATGCAAGCTTTAGCTGCCCGAATGCGTCACCCCGATGCGCCCAGATCGGGGCTTCGCAGATAAAGCACGAACAGGCGGGCAAAACGTCNATCTCGGAGCCG (SEQ ID NO. 443) GAAGGGCAATCAGCCGACCGTCGACGAACGACACCGGCGAGACCACTTAGGCAGTGACGGCCGGCCCGAACATTACGCGCTCGTTGATTAGGCGTTCGGTCTCGTC CGCGGTCATGCCGAGCAGCTTGCGGCAGATCTGAACGCTGTCCTGTCCGGGCAGCGGCGCCGGGCGTTGGGGTGCCTGCCCGAATGTGACGAAACGGAGCCGGACC CGTCTCGGCGGGCCGCGGACGGCGATCCGC Clone Rv340 :::::::::::::Rv340SP6.seq::::::::::::: CNCAAGCTTGCGGATGTTACCCCTGACAGCCTGAACTATGTCNAAACACACGGCACCGGAACGGTGTTGGGGGACCCCATCGANTTCGAGTCGCTGGCGGCCACTT (SEQ ID NO. 444) ATGGCCTGGGTAAAGGCCAGGGCNANAGCCCGTGCGCATTGGGGTCGGTCAAAACCAACATCGGCCACCTGGAGGCGGCCGCCGGTGTGGCTGGATNCATCAAGGC GGTGCTGGCGGTGCAACGTGGGCACATTCCCCGCAACTTGCACTTCACCCGGTGGAACCCGGCCATCNACGCGTCGGCNACGCGGCTGTTCGTGCCNACCNAAAAC CCCCCGTGGCCGGCGGC :::::::::::::Rv340T7.seq::::::::::::: GGAACCGGTAACCAGATCAGCTCGTCGACCTCACTGCCGGGGGTGAATTCCCCACCGGTGCTGCGCGCTGCCCAGTAGTGCACCTTCTTGACGCCTCGAAAAGGGG (SEQ ID NO. 445) AGTCGGTCGGGTAGGTCACCGTCAGGAGCCGCCTACCCAGGTTGGCGCNATAGCCGGTCTCCTCGAGTATCTCCCGCACCGCCCCCACCGGTGCGGTCTCACCCAN ATCCACTTTGCCCTTGGGCAGCGACCAGTCGTCGTANCNGGGGCGGTGAATGACAACGATCTCGACCGGCCCTTCCN Clone Rv341 :::::::::::::Rv341SP6.seq::::::::::::: TACTCAAGCTTCAGAACAGGCCTGTTGTGGGCNCACCCGGCTCGCCGAGTTCTGCACGCACCGCCTCAAGTGCGGCCCGCACCGCCGGCATCTCCCGGTCACGCAG (SEQ ID NO. 446) GGCCGCGGCCCGCGCCGCAGCGACGGCGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGTTCTCGGCGTCGTCGCGTTCACTAATC GCGGTGCTCAGCAGCGTCTCGACAGCCACCACCCGAGTGGCGACCAGCTGC :::::::::::::Rv341T7.seq::::::::::::: TAATGTCTTGCCAACGTCACCACAATCGCGATGAATTCAATCATGCCGCCCAGGGCGGCCAACCCAATGGTGGCCGCGAGCGGCAGCTCGATCGCAGCGCGGAGGT (SEQ ID NO. 447) TGCCGGCCGCCAGTTGATTCACGAACAGGGTGAGGTCATAGGCGGGCAGGATAGTGACGAAGGCAAGACCTATATCTGCCGTCGGAAGAAGAATCGAGTAGCCGGT CGACACAACGGAAGCGAAAGTGTCCGCGATGTTGATGAGCGTCGCCGGTTGTGGCGGCGGTGGCGGC Clone Rv343 :::::::::::::Rv343SP6.seq::::::::::::: TACTCAAGCTTTCGTCAGTTCATCGCGCCAGCAGACCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGC (SEQ ID NO. 448) GCGAACGACGCCAGCGACCACATTCAGCANATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCGACATCGTCA CCGCCGCACCACTGCCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGANNATCACATCGCCGCGATCGCCCTGTTC :::::::::::::Rv343T7.seq::::::::::::: CCACCCGTGTAATTTGGGATGGGCNAAAAGGCNAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAAC (SEQ ID NO. 449) GTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGG TAGTCGCCGCCCGGGCGGCTACAGTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCGACG Clone Rv344 :::::::::::::Rv344SP6.seq::::::::::::: TCAAGCTTTAGCTGCCCGAATCCGTCANCCCGATGCNCCCAGATCGGGGCTTCGCANATAAAGCACNAACAGGCGGGCAAAACGTCNATCTCGGAGCCGGAAGGGC (SEQ ID NO. 450) AATCANCCGACCGTCNACAAACGACACCGGCGANACCACTTAGGCAGTGACGGCCGGCCCGAACATTACNCGCTCGTTGATTAGGCGTTCGGTCTCGTCCGCGGTC ATGCCGAGCAGCTTGCGGCANATCTGAACGCTGTCCTGTCCGGGCAGCGGCGCCGGGCGTTGGGGTGCCTGCGGAATGTGACNAAACGGAGCCGGACCCNTCTCGG CG :::::::::::::Rv344T7.seq::::::::::::: CCGGGGCCACTCCGCACAATCNGTACCNNACCAANATCTACACCATCGAATACGACGGCGTCGCCGANTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAA (SEQ ID NO. 451) CGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCGGAACAAATNGACGCNTCGGTTCCGCTGACCAATACGGTCGGTCCC Clone Rv346 :::::::::::::Rv346SP6.seq::::::::::::: NCTGGCCTTTGGTCCACACTAANACAATACTCAAGCTTCCGGCCGCAGAGCCGCCAACTCACGATATCGTTAACCGATATCCCGAGCCGATAGCTGGCGGGCTCGG (SEQ ID NO. 452) GTGGTGGCCAGCGGCGCTGCGACNAAAGGTGTGACCGTCATGAAACAGACACCACCGGCGGCCGTCGGCCGTCGTCACCTGCTCGANATCTCAGCATCCGCAGCCG GTGTGATCGCGCTTTCGGCGTGTNGTGGGTCNCCGCCCGAGCCCGGCAAAGGCCGGCCCGACACAACCCCGGAAC :::::::::::::Rv346T7.seq::::::::::::: CATCTGCCCACCACACGGACCGCGGTGCGGACGCGGCTGACGCGCCTGGTGGTCAGCATCGTGGCCGGTCTGCTGTTGTATGCCAGCTTCCCGCCGCGCAACTGCT (SEQ ID NO. 453) GGTGGGCGGCGGTGGTTGCGCTCGCATTGCTGGCCTGGGTGCTGACCCACCGCGCGACGACACCGGTGGGTGGGCTGGGCTACGGCCTGCTATTCGGCCTGGTGTT CTACGTCTCGTTGTTGCCGTGGATCGGCGAGCTGGTGGGCCCCGGGCCCTGGTTGGCACT Clone Rv347 :::::::::::::Rv347SP6.seq::::::::::::: GACAATACTCAAGCTTGACTGGCCACCCACCGGCATGACCACCGACAGGCCCGACTGGTCGTACCACTCGAACGCCGGGGTGTTGATGTCCCAGCCGCTGAANTCG (SEQ ID NO. 454) TCCTGCGCGCGCAGGCCGTCNAACAGGTACAGGGCGGGCGAATTGGCACCACCACTTTGGAATTGGACCTTGATGTCACGGCCCATCGACGGCGACGGCACCTGCA GGTACTCCACCGGCAAGCCCGGCCGGGAAAATGCCCCCGCGGTCNCCGTGCCACCGACGGCGCCGANCAAACCCGACACTAGGGCCGCGCCNACGGCCCCGACCAC NANTCNACGCGACATACCCGTGACGGCGCCACNAACCCTGTCAACA :::::::::::::Rv347T7.seq::::::::::::: CCTCCAACTCGGCGGGGAAGCGACNCCAGCCTACCGAGCTTGGAGTCCANGACGCCAGCGGCGGCGTCGGTCTGCGTCGTGGTGCCGCCGGGGTGGCGTTGGCTGG (SEQ ID NO. 455) CAACGATCTCCACCCAGCCGGTCGGGTTACCCACGATCTCGGCATANACGCGGGCCGAGGCCGGTGCGATACCGTATTGCGTCAATTGGGACGCGGTTGTGCATTC GGCTAGCTCGGTTGCCACACCCGTCAGGGGTTCGACGTTGGCGGGTTCGGCGGGCCCCANCACCGCTGTCACCATGCCCGCCAAGCCGACCTGCGGCGCCACCAAC TGCAGCACCANCATGTCGCCGTCGCGCGCCGCGATCACATGG Clone Rv348 :::::::::::::Rv348SP6.seq::::::::::::: CTCAAGCTTTTTGAGCGTCGCGCGGGGCANCTTCGCCGGCAATTCTACTANCGAGAANTCTGGCCCGATACGGATCTGACCGAANTCGCTGCGGTGCANCCCACCC (SEQ ID NO. 456) TCATTGGCGATGGCGCCGACNATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGTCAAGTCCGGTCTACGCTTGGGCCTTTGCGGAC GGTCCCGACGCTGGTCGCGGTTGCGCCGCNAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCNCCGCCGCGGCACTGCACGGCCAGTGCCGCGGCGA :::::::::::::Rv348T7.seq::::::::::::: CNCCAGCTTGATTGGTCTGGTTGCATTGGCCAGCTGCGCGAGCCTGGCTCACTTCAACTACGACGACCGCAAACAATTGCCGCCTTCGGATCCGAGTTCGGTTGGG (SEQ ID NO. 457) TACGCGGCAATGGAGCACCATTTCTCGGTGAATCAGACTATTCCTGAGTACTTGATCATCCACTCTGCACACGACCTGCGAACCCCGCGCGGCCTTGCCGACCTGG AGCAGCTGGCGCAACGTGTGAGCCAGATCCCAGGCGTTGCCATGGTTCGCGGTGTGACCCGGCCAAACGGGGAAAC Clone Rv349 :::::::::::::Rv349SP6.seq::::::::::::: CAATACTCAAGCTTGACTGGGCCCGCACCTTCGGCGCCACCCACACCGTCAACGCCCGCGAAGTCNACGTCGTCCAGGCCATCGGCGGCCTCACGGATGGATTCGG (SEQ ID NO. 458) CGCGGACGTGGTGATCGACGCCGTCGGCCGACCGGAAACCTACCAGCAGGCCTTCTACGCCCGCGATCTCGCCGGAACCGTTGTGCTGGTGGGTGTTCCNACGCCC GACATGCGCCTGGACATGCCGCTGGTCNACTTCTTCTCTCACGG :::::::::::::Rv349T7.seq::::::::::::: TCGACGGTTTGGCGGCCTTAAATGCACTGAGGTCGTCAATTGACCCCACAGCGGAAATGCCGACTATTCGCAGGCCTCCTTCGCCTTGGCTGCCGGAGAGGGGCTC (SEQ ID NO. 459) CGCGGGAACCGCATGCAGGTATATGACCTCGGTTTCTCGGGTGCTACCGCGTGCCTTGTNTANGATNANCTCGGCGTTGGAATTGTCCAGCCGGCCCAATTCATCG AGCGCANATTCGTACACNTGGCCGGCGGCGACATACGCTTCACCGTGGATCTGCTCCACACGGACCGCCCTGTCGGGATCCTGCTCACGGGTAANGGAACTTACGT GGCACTCGG Clone Rv34 :::::::::::::Rv34SP6.seq::::::::::::: GACCACGCCAGGCTAATCACGTGACGCTACCGAATACCCTNCCTAGTGGTGCAGGCTCCCGCTGGAAATGGCCCTGTACCAACTCGCGCACCGGTGCCAG (SEQ ID NO. 460) :::::::::::::Rv34T7.seq::::::::::::: CGGCACCCGACCCCTTTGAGCCGTCCGCCGTGGCCGCGGTGGAACTGGCCGACGAGGGACTGATCGTGCTGGGCAAATTGGTCGATGGCACGCTGGCCGCCGATCT (SEQ ID NO. 461) GAAGGTCN Clone Rv350 :::::::::::::Rv350SP6.seq::::::::::::: CTCAAGCTTGCCGTTACCCCGACTTCCGGAGGGACACCATGAGCACCGCCAGCCGAGCACGAGGCCAAACTCCGCCGACGCAGGCCGGTTGGACTTGTCGTGCTGG (SEQ ID NO. 462) ACAAGGGGTTTAGCCGCCGAAGCAGTGACGTACATCGGCGAAAAGCAGTTCGCCTGTCGACCGACGGNGCNNACCGTGAGGCTAGGGAAGCGAGGAGCACATGGCC GCCGACCCGCAATGTACACGCTGCAAGCAAACCATCGAACCCGGATGGCTATNCNTCACCGCCCATCGCCGCGGT :::::::::::::Rv350T7.seq::::::::::::: CATGTCGCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGCGGATGATCGGGCCGCCTACGTCGTGGTGTACCTCGTCGGTAACA (SEQ ID NO. 463) ACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAAGGCCTATGTCACCGGTCCGGCAGCACTCAA TGCCGACCAGGCCGAGGCCGGAGACAAAAGTATCGCTAAGGTCACCGCGATCACGAGCATGGTGATCGCAGCAATG Clone Rv351 :::::::::::::Rv351SP6.seq::::::::::::: ATACTCAAGCTTCGGTACGGTGGCGGGCCGTGCTGCTGGCCGCGGTCGCGGCGTGCGCGGCCTGCGGTCTCGTTTACNAGCTCGCGCTGCTGACACTGGCGGCNAG (SEQ ID NO. 464) CCTGAACGGCGGCGGGATCGTGGCCACCTCCCTGATCGTCGCGGGCTACATAGCCGCGCTGGGAGCAGGCGCCTTGCTGATCAAGCCGCTACTTGCACACGCGGCC ATCGCGTTCATCGCCGTGGAGGCGGTGCTGGGCATCATCGGCG :::::::::::::Rv351T7.seq::::::::::::: TGTCAAGTCCTTTCAGATCTCNTTTTTATGACATGACTGGAGATCTGTCTAGATTGCAGCTCCTGTGAGCGTGGGTACCGGATTCAAGCCGGTCGGTCACGCCGCG (SEQ ID NO. 465) GTGGTACCGGCTTTGCGGCAGTGCTCGGCCTCGAGTTCGGCGATCGCGCGCGAAGTGCGTTCGCGCAGCAAGATCGCGGCCGTAATGCCGGCGATGACCGCGATGA CCAGCGCGATCCAGGAGAACCGTTCCAACCAGTGCTGGGCGGCCATCCCGGCGAAGTAGACCAGTGCAGTGGTGCC Clone Rv352 :::::::::::::Rv352SP6.seq::::::::::::: CAATACTCAAGCTTCAAAACAGGCCTGTTGTGGGCGCACCCGGCTCGCCGAGTTCTGCACGCACCGCCTCAANTGCGGCCCGCACCGCCGGCATCTCCCGGTCACG (SEQ ID NO. 466) CAGGGCCGCGGCCCGCGCCGCANCGACGGNGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGTTCTCGGCGTCGTCNCGTTCACTA ATCGCGGTGCTC :::::::::::::Rv352T7.seq::::::::::::: TACGCTGGCGCTGGAGGGAGCCANNTACAACATCCACGCCAATGCTCTTGCCCCGATCGCGGCGACCAGGATGACCCAGGACATCCTGCCGCCCGAAGTACTGGAA (SEQ ID NO. 467) AAGCTCACACCCGAGTTCGTCGCACCGGTGGTGGCCTACCTGTGCACCGAGGAGTGTGCCGACAACGCATCGGTGTACGTCGTCGGTGGTGGCAAGGTGCAGCGAG TTGCGCTGTTTGGCAACGACGGCGCCAACTTCGACAAACCGCCGTCGGTACAAGATGTTGCGGCGCGGTGGGCCGAGATCACCGATCTGTCCGGTGCGAAAATTGC TG Clone Rv353 :::::::::::::Rv353SP6.seq::::::::::::: GCTTTTCCCGTCCGTCNNCGCTCAACCGCGTGAGGCCGAAGCGGNTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACNCCC (SEQ ID NO. 468) GACCAGCCGATGCTGGAGGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGANCGGCTGCNNNTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCGA CCCTGCTGGCAAANATCATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGANCTGGAAC :::::::::::::Rv353T7.seq::::::::::::: CNGCTTTTTAATGGCCTTGACNTGGGCGNGCCGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACT (SEQ ID NO. 469) TTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGC GGTTCCGCTGACCAATACGGTCGGTCCCAAGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGG AACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGGCGACCCGGCCTATG Clone Rv354 :::::::::::::Rv354SP6.seq::::::::::::: CTCAAGCTTGCCGGGAGGGTGCATGGCCGACTCGGATTTACCCACCANGGGGCGCCAACGCGGTGTCCGCGCCGTCNAGCTGAACGTTGCTGCCCGCCTGGAGAAC (SEQ ID NO. 470) CTGGCGCTGCTGCGCACCCTGGTCGGCGCCATCGGCACCTTCGAGGACCTGGATTTCGACGCCGTGGCCGACCTGAGGTTGGCGGTGGACGAGGTGTGCACCCGGT TGATTCGCTCGGCCTTGCCGGATGCCACCCTGCGCCTGGTGGTCGATCCGCGAAAANACGAANTTGTGGTGGAGGCTTCTGCTGCCTGCGACACCCACNACGTGGT GGCACCGGGCAGCTTTAGCTGGCAT :::::::::::::Rv354T7.seq::::::::::::: CCGACGCCGTCGTGGCCACCAACACCGCGACCAGCACCGTGACCCGGACCGGGGTGCCGCGCGAACCGGTCTTGGCCAATTGCCGCGGCACCAAGCCGTCGCGCGC (SEQ ID NO. 471) CATGGCGAACAGCACGCGGCATTGCCCGAGCATCAACACCATCACCACCGTGGTAAGCCCGGCCAGCGCGCCGACGGAGATGATGCCGCTGGCCCAGTACACCCCG TTGGCCTGGAACGCGGTGGCCAGATTTGCCGGCCCGCGGCCCGGTACGGTCCGCAGTTGGGTGTATGGAACCATGCCCGACAGCACCACCG Clone Rv355 :::::::::::::Rv355SP6.seq::::::::::::: TTNACTGGCCTTTGGTCCACACTAGACAATACTCAAGCTTCCAGGACATCGTCATCGCGACCAAAACCGCGAGCTAGGTCGGCATCCGGGAAGCATCGCGACACCG (SEQ ID NO. 472) TGGCGCCGAGCGCCGCTGCCGGCAGGCCGATTAGGCGGGCAAATTAGCCCGCCGCGGCTCCCGGCTCCGANTACGGCGCCCCGAATGGCGTCACCGGCTGGTAACC ACGCTTGCGCGCCTGGGCGGCGGCCTGCCGGATCAGGTGGTAAATGCCGACA :::::::::::::Rv355T7.seq::::::::::::: NGACGTCTTCCATCCGCGCGTCGTTTTGGCGGGTTGGCCACAGCAGCCCGCCGGTGACGGCGACGATGCTGGGCTGGTTGCGGCCCTGCGCCACCGCGGCTTGCAT (SEQ ID NO. 473) GCTGGTTGGCTGTCTTGGGACGATCCCGAAATAGTCCACGCGGATCTGGTGATTTTGCGGGCTACCCGCGATTACCCCGCGCGGCTCGACGAGTTTTTGGCCTGGA CTACCCGCGTGGCCAATCTGCTGAACTCGCGGCCGGTGGTGGCCTGGAATGTCGAGCGCCGTTACCTA Clone Rv356 :::::::::::::Rv356SP6.seq::::::::::::: CTTCCTCCTGAGTACCNCCCGTNTACTTTGGGATGGGTAAAAAGGCGAATCNCCGTTTGGTCACGAACGCCGGGAGGGACAATCTCGGGCGGCTGGGGCCTCTCGC (SEQ ID NO. 474) GGGAANGCCCGAATGTACGGTGTCTCGACACTTCCCNTCCCCCTCCG :::::::::::::Rv356T7.seq::::::::::::: GAGCATCGGGACNTACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCNGCGACCACATTCAGCAGATGGCCAGCGCG (SEQ ID NO. 475) TGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCNTGATCNACATCGTCACCGCCGCACCACTGCCCGGCCTCGGGTTCACGCAGCCGTTGC CGCCCNCAGCGGACGATCACNTCGCCGCGATCGCC Clone Rv357 :::::::::::::Rv357SP6.seq::::::::::::: TACTCATGANCATCCTTTAATCANNGCTTTGCGTTTTTTTATTAAATCTTGCAATTTACTGCAAAGCAACAACAAAATCGCAAAGTCATCAAAAAACCGCAAAGTT (SEQ ID NO. 476) GTTTAAAATAAGAGCANCACTACAAAAGGAGATAAGAAGAGCACATACCTCAGTCACTTATTATCACTAGCGCTCGCCGCAGCCGTGTAACCGAGCATAGCGAGCG AACTGGCGAGGAAGCAAAGAAGAACTGTTCTGTCAGATAGCTCTTACGCNCA Clone Rv358 :::::::::::::Rv358SP6.seq::::::::::::: CTCAAGCTTCAGGTCAATGTGCNCCAAGCCCTGACGCTGGCCGACCAGGCCACCGCCGCCGGANACNCTGCCAAGGCCACCGAATACAACAACGCCGCCGAGGCGT (SEQ ID NO. 477) TCGCANCCCAGCTGGTGACCGCCGAGCANANCGTCAAAAACCTCAAGACGCTGCATGACCAGGCGCTTANCNCCGCANCTCAGGCCAAGAAGGCCGTCNAACGAAA TGCGATGGTGCTGCACCANAAGATCGCCGAGCGAACCAAGCTGCTCAGCCNG :::::::::::::Rv358T7.seq::::::::::::: CATGGTGGCACTGTAGCGACGTGCTGCAATCAAGGTCATGCCCGACTCTGGTCAGCTCGGANCCGCTGACACCCCGCTAAGGCTGCTCAGCTCGGTGCATTACCTC (SEQ ID NO. 478) ACCGACGGCGAACTCCCCCAGCTTTACGACTATCCGGATGACGGCACCTGGTTGCGGGCGAACTTCATCATCAGCTTGGACGGCGGCGCTACCGTCGATGGCACCA GCGGGGCGATGGCCGGGCCCGGCGACCGATTCGTCTTCAACCTGTTGCGTGAACTTGCCGACGTCATCGTGGTCGGCGTGGGCACCGTGCGCATTGAGGGCTACTC CGGCGTCCGGATGGGTGTCGTCCAGCGCCAGCAC Clone Rv359 :::::::::::::Rv359SP6.seq::::::::::::: TACTCAAGCTTGCGGGTGATCGCCTTGGTCAACGGCACCGTGATCGGATCGGGGTCNACCGCACAAATGGACTGGAGCTTCGGCGAANTCATCGCCTATGCCTCGC (SEQ ID NO. 479) GGGGGGTGACGCTGACCCCGGGTGACNTGTTCGGCTCGGGCACGGTGCCCACCTGCACGCTCGTCTATCACCTCNGGCCACCGGAATCATTCCCGGGCTGG :::::::::::::Rv359T7.seq::::::::::::: GTTGGNGCCTCGTCGGCGAACAGTTCTCGCACGATTTCCGGATTAGCGGGACTGGTCACCAGTTGGGTATGCGGGAAGGCGCTGACGTTCGCCGCGATTAGCTGTT (SEQ ID NO. 480) TGATGGACGCGGTGGTGATGTTCTGATCACGGAACTGGCTGTAATAGCCCAGGGTCGCCACGCTTTCATCCGGGCCCGGACCCGGCGCACCGAGCGTGTCGCGCAG GTATGCGACGTGATTTTCGCTGAAGTCCCCGTACCCGGAGAACT Clone Rv35 :::::::::::::Rv35SP6.seq::::::::::::: TGCTTCCGGCTCGTATGTTGTGTGGAATTGTGANCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT (SEQ ID NO. 481) ACTCAAGCTCCAGGTCAATGTGCGCCAAGCCCTGACGCTGGCCGACCAGGCCACCGCCGCCGGAGACGCTGCCTTTGTCACCGAATACAACAACGCCGCCGAGGCG TTCGCAGCCCAGCTGGTGACCGCCGAGCAGAGCGTCGAAGACCTCAAGACGCTGCATGACCAGGCGCTTAGCGCCGCAGCTCAGGCCAAGAATGCCGTCGAACGAA ATGCGATGGTGCTGCGGCATAAGATCGCCGAGCGAACCAAGCTGCTCAGCCAGCTCGAGCAGGCGAAGATGCACGAGCA :::::::::::::Rv35T7.seq::::::::::::: CAGGCATGCAAGCTTCGGAGGCAGACCCGTGCATGGTGGCACTGTAGCGACGTGCTGCAATCAAGGTCATGCCCGACTCTGGTCAGCTCGGAGCCGCTGACACCCC (SEQ ID NO. 482) GCTAAGGCTGCTCAGCTCGGTGCATTACCTCACCGACGGCGAACTCCCCCAGCTTTACGACTATCCGGATGACGGCACCTGGTTGCGGGCGAACTTCATCAGCAGC TTGGACGGCGGCGCTACCGTCGATGGCACCAGCGGGGCGATGGCCGGGCCCGGCGACCGATTCGTCTTCAACCTGTTGCGTGAACTTGCCGACGTCATCGTGGTCG GCGTGGGCACCGTGCGCATTGAAGGCTACTCCGGCGTCCGGATGGGTGTCGTCCATCGCCA Clone Rv360 :::::::::::::Rv360SP6.seq::::::::::::: TACTCAAGCTTGGGGTGGCGCTGTCGGTCGGTGTGCTTGGCGGCGTCGGTATCAACACCGCCCACGAAATGGGGCACAAGAAGGATTCGCTGGAGCGGTGGCTGTC (SEQ ID NO. 483) CAAAATCACCCTCGCCCANACCTGCTACGGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCCGGGTGTCCACACCGGAGGACCCGGCGTCGGCGCGGTTC GGCNAAACGTTGTGGGANTTCCTGCCCCGCANTGTTATCGGCGGCTTGCGCT :::::::::::::Rv360T7.seq::::::::::::: GGCCATCGCCACCGCNCCGCGGCGAACGCTCAAAGGCACCTACTGGCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGCGCCGACCCCGCCCGAGGTCCTGGC (SEQ ID NO. 484) CGTTACCACCGAACGGGCGAGCCGGGAGTCTGGTACGCATCGAACAAAGAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGGTCGATCCAT TCGAGGTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCANGTACTCGACCTCACAGACGAGAGGACTCGATCCCATCTAGGTGTGGACGAAACAGATCTTCT GTCCGACGACTACACCACCACCCAGGCCATCGC Clone Rv361 :::::::::::::Rv361SP6.seq::::::::::::: GCTTGCGGGTGATCGCCTTGGTCAACGGCACCGTGATCGGATCGGGGTCNACCGCNCAGATGGACTGGANCTTCGGCGAANTCNTCGCCTATGCCTCGCGGGGGGT (SEQ ID NO. 485) GACCCTGACCCCGGGTGACNTGTTCGGCTCGGGCACGGTGCCCACCTGCACGCTCGTCAAGCACCTCNGGCCACCGGAATCATTCCCGGGCTGGCTGCACNACGGC GACNTGGTCNCCCTCCAGGTCGAAGGGCTGGGCNAAACAANGCAGACCGTCCGGACAANCGGCACTCCTTTTCCGTTGGCTCTTCGGCCGAATCCGGACGCCNAAC CCGACCGGCG :::::::::::::Rv361T7.seq::::::::::::: GTTCTCGCACGATTTCCGGATTAGCGGGACTGGTCACCAGTTGGGTATGCGGGAAGGCGCTGACGTTCGCCGCGATTAGCTGTTTGATGGACGCGGTGGTGATGTN (SEQ ID NO. 486) CTGATCACGGAACTGGCTGTAATANCCCAGGGTCGCCNCGCTTTCATCCGGGCCCGGACCCGGCGCACCGAGCGTGTCGCGCAGGTATGCGACGTGATTTTCGCTG AAGTCCCCGTACCCGGAGAACTCGAACACGCTGAGGCGCTCGTCACCGTCGTNNCGGCGACCAAGCGCGGCGAGCAACTGCGCAAAATCGTTAAGANAGGTCGAAT CGTTGAAATTCGGCACCACCTGCACC Clone Rv363 :::::::::::::Rv363SP6.seq::::::::::::: CACAAGACAATACTCAAGCTTCAGGTCAATGTGCNCCAAGCCCTGACGCTGGCCGACCAGGCCACCGCCGCCGGANACGCTGCCAAGGCCACCGAATACAACAACG (SEQ ID NO. 487) CCGCCGAGGCGTTCGCAGCCCAGCTGGTGACCGCCGAGCANANCGTCNAAAACCTCAAGACGCTGCATGACCAGGCGCTTANCGCCNCAGCTCAGGCCAAGAAGGC CGTCGAACGAAATGCGATGGTGCTGCAGCANAANATCGCCGANCGAACCAAGCTGCTCAGCCAGCTCGAGCAG :::::::::::::Rv363T7.seq::::::::::::: CCACCCGTGCATGGTGGCACTGTAGCGACGTGCTGCAATCAAGGTCATGCCCGACTCTGGTCAGCTCGGAGCCGCTGACACCCCGCTAAGGCTGCTCAGCTCGGTG (SEQ ID NO. 488) CATTACCTCACCGACGGCGAACTCCCCCAGCTTTACGACTATCCGGATGACGGCACCTGGTTGCGGGCGAACTTCATCAGCAGCTTGGACGGCGGCGCTACCGTCG ATGGCACCAGCGGGGCGATGGCCGGGCCCGGCGACCGATTCGTCTTCAACCTGTTGCGTGAACTTGCC Clone Rv364 :::::::::::::Rv364SP6.seq::::::::::::: GCTTTCCGCCGATACCCNCCATGTCCCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGCGGATGATCGGGCCGCCTACGTCGTG (SEQ ID NO. 489) GTGTACCTCGNCGGTAACAACGAAACCGAANCGTATGACTCNGTCCACGCGGTG :::::::::::::Rv364T7.seq::::::::::::: CAACCCGANTTGGCTTTCGGCGCCNTCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCGGTCG (SEQ ID NO. 490) AACGCAAGCAGCTGATCGATCTACNACGCCGNGNGGAACGCTTCNGCCGCGGGCGTGACCGCNTCCCGTT Clone Rv365 :::::::::::::Rv365SP6.seq::::::::::::: GGGATGGGCAAAAAGGCGAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAACGTACGGCGTTTCAAC (SEQ ID NO. 491) ACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCCAGCGTCCCCGCGGGTAGTCGCCGCCCGG GCGG :::::::::::::Rv365T7.seq::::::::::::: CAGCAGACCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCAGCGACCACATTCAGC (SEQ ID NO. 492) AGATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCACGGTT Clone Rv366 :::::::::::::Rv366SP6.seq::::::::::::: CTCAAGCTTGACTGGCCACCCACCGGCATGACCACCGACAGGCCCGACTGGTCGTACCACTCGAACGCCGGGGTGTTTGA (SEQ ID NO. 493) :::::::::::::Rv366T7.seq::::::::::::: TTGGTGCCCGGAATGGCGAGTCCCATTTANTCGCTGATTTGTTTGAACAGCGACGAAACCGGTGTTGAAAATGTCGCCTGGGTCGGGGATTCCCTCTCCAAGCAAG (SEQ ID NO. 494) AGTAACTGGCCCCAAATAAAGTTACTCGTCGTCTTGCAAAGACCGCTACCCGATGCCATTTATGTGTTTCCTTACGCTCNNNNTTCCGGTGCGCCATCATTATCTG CACCTTTGCACTGCACATTGAGCTTAGCAGCGCTCG Clone Rv367 :::::::::::::Rv367T7.seq::::::::::::: GAATTNGCTTTCGGCGCCATCGGCCCAGGACCGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCGGTCGAACGC (SEQ ID NO. 495) AAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCNGTGATCGTCGATGACGGCATCGCCA CCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCAGACGACATCGTGGCGAGATTCGC CGGGTACGCCGATGAAGTGGTGT Clone Rv368 :::::::::::::Rv368SP6.seq::::::::::::: TAAAGCTTTCGTCAGTTCATNGNGCCCCCGGACCAACAAAAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCN (SEQ ID NO. 496) AACGACGCCAGCGACCACATTCAGCAGATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCNACATCGTCACCG CCGCACCACTGCCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGACGATCACNTCGCCGCGATCGCCCTGTTCGGGAATCCCTCGGGCCGCGCTGGCGG GCTGATGAGCGCCCTGACCCCTCAATTCGGGTCCAANACCATCNACCTCTGCAACAACGGCGACCCGATTTGTTCGGACGGCAACCGGTGGCGANCGCACCT :::::::::::::Rv368T7.seq::::::::::::: CCGGGAGGGACCATCNCGGGCGGCTNCGGCTTCTCTCCGGAAGGTTCTANNGTNNNGCGTTTCNACNCTTCCCGTCGCCCTGCGACCGCCGAACATTCGGGGTATG (SEQ ID NO. 497) GNNGCANCCTGTNAGCATCCNGGCCGGGC Clone Rv369 :::::::::::::Rv369SP6.seq::::::::::::: CTCAAGCTTCCGCATCAGATCGCTATAGAACCGGTGCGCGTCCCCACCGAGTGGCTGGTCGCCTTCCAGCACGATCGTTACCGCGTTATCGGAATCAAACTCNCCG (SEQ ID NO. 498) AACACCTGACCAACGCGCTTGATCGCCTGAATCGATGCGGCGTCGCTGGGGCTCATCGATACCGAGTGTGCTTTTCCGACCACTTCCAGTTGCGGTACGGCGAGAT TGACAAAGGCGGTGAAGCCCAGCCAGAGCAGGACGATCACCNCCGCAAACCGGCGGATTTGCCCG :::::::::::::Rv369T7.seq::::::::::::: GCTTGGCAGCCTGCGGCTGGGCGCCCTNGAGCTCTTCGATCTGGATCTCCGGACTCGAGATGCTCACTTGCCCGGCCGTGGACGTACCCATTGCGGCCGGGACCCC (SEQ ID NO. 499) AGCGCCCCAGGTGACCAGCGAGTTGGGCTGCACGCTGACCGGCCCGTCGGGGTCGACGCCGGTAACGGTCAGCAGCTCCGANGTCCNNCTGATCCCGACCGCAGCT GCCAATGCGCGGCTGGCAGCCGACGTGGATGTGCCGGGGCCTAGATCGCGGGGCAGCAGCGAGACCGCGTCACCGACGGTCATCACCTTGCCGAGTTTNGGCCTGC CGCAN Clone Rv36 :::::::::::::Rv36SP6.seq::::::::::::: GCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTNCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATCTAGGTGACACTATAGAATA (SEQ ID NO. 500) CTCAAGCTTGAGCCATCGGGCTATCAGCTGGTTGATGTCCCG :::::::::::::Rv36T7.seq::::::::::::: CAGGCATGCAAGCTTGTCGTCTATCACATCCGACCACCAACCGCCCGACGGCTCGGCAGAACGCCTCCGCATATGGGTCGACGACCAGCGGGTCGGACTTCTGGGC (SEQ ID NO. 501) TGCCAGCGCTCGCGCCGTCGCGACAAACAGCGCGGTCGAACCGACACTCCTTGTGATGTCCCACCTATCACCTTCGGTACGCACCCAATCGACCCTACGCGGCTAG CTCAGCCCCGATCTTCCAGAGCTCCGCCCG Clone Rv370 :::::::::::::Rv370SP6.seq::::::::::::: GCTTTTTGAGCGTCGCGCGGGGCGGCTTCCCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGCCCACCCTCATT (SEQ ID NO. 502) GGCGATGGCGCCGACNATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGTCAATTCCGGTCTACGCTTGGGCCTTTGCGGACGGTCC CGACGCTGGTCGCGGTTG :::::::::::::Rv370T7.seq::::::::::::: CGANCCTGTTCGACGGCTACCTGAATCACCCCGATNCCACCGCCGCGGCGTTCGACGCCGACAGCTGGTACCGCACCGGCGACGTCGCGGTGGTCGACGGCAGTGG (SEQ ID NO. 503) GATGCACCGCATCGTGGGACGCGAGTCGGTCGACTTGATCAAGTCGGGTGGATACCGGGTCGGCGCCGGTGAAATTGAAACGGTGCTGCTCGGGCATCCGGACGTG GCGGAGGCGGCAGTCGTCGGGGT Clone Rv371 :::::::::::::Rv371SP6.seq::::::::::::: NAAGCTTTGTCACACCAAGTGTTTCNACCAGNCGCTCCATCCGGCGAAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCAGCTC (SEQ ID NO. 504) GCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCTGGCG :::::::::::::Rv371T7.seq::::::::::::: CGCTGGNCGCCGGCGCTGGGCTGCGGTAACCAATTACCACAACACTTTTCGGTAGCCGAACAGCGGCGCGTACCAGCGAAATGGCACAGCCACCGCAGTCGCCGAC (SEQ ID NO. 505) ATCCCGCGAAGATGTGGCAGATTTTCGTGCGGTCGAGCCGGCGAAGGCCTAGCGTCATTGTTGCCTGGCAAGGTTGCTGGGCCCGG Clone Rv373 :::::::::::::Rv373SP6.seq::::::::::::: CTCAAGCTTCTTCTGCCCCTTGCCGTTNCGGATNACATCCCGCAGCGACTCGGCTTCGGCGTCGATGTCGAAGTTCTCGATCAGCTTCTGGATCGACTCCGCGCCC (SEQ ID NO. 506) ATGGCACCGGTGAAGTACTCGCCGTAGCGGTCGACNAGTTCGCGGTAGAGGTTTTCGTCNACNATCAGCTGCTTGGGCGCCANCTTGGTGAAAGTGCTCCAAATGT CCTCCAACCGGTCCAGCTCACGCTGCGCGCGGTCACGGATCTGGCGCATCTCGCGCTCGCCGCCGTCGCGAACTTGCGCCGCGCATCGGCCTTGGGGCCC :::::::::::::Rv373T7.seq::::::::::::: GTTCACACCTACCTACTATGCCNCAATTCNCCGACACGGGTGGCATCAACACGGGCGATAAGGTGGAAATCGCTGGGGTGAACGTCGGGCTGGTGCGCTCGCTGGC (SEQ ID NO. 507) AATCCGCGGCAACCGCGTGTTGATCGGATTCTCGTTGCCCGGCAAGACAATCGGGATGCAAAGCCGGGCAGCAATTCNCNCCNACACCATTCTTGGCCGTAAGAAC CTGGAGATCGAACCCCGCGGTTCGGAGCCGTTGAAACCCAACGGTTTCCTGCCGTTGGCGCANACCACTACGCCATACCAAATC Clone Rv374 :::::::::::::Rv374SP6.seq::::::::::::: CTCAAGCTTTACGCCGACGCCGGCCTACACAACACCAAGGAAACGATTGCCTACTGCCGAATCGGGGAACGGTCCTCGCACACCTGGTTCGTGTTGCGGGAATTAC (SEQ ID NO. 508) TCGGACACCAAAACGTCAAGAACTACGACGGCAGTTGGACAGAATACGGCTCCCTGGTGGGCGCCCCGATCGAGTTGGGAAGCTGATATGTGCTCTGGACCC :::::::::::::Rv374T7.seq::::::::::::: TCCCNCATGGGATAACGGGTTTAGATTTCNACAACGGCACCGTGTTTCTCAACAAGCCGGTCATCAGCTGGGCCGGCGACAACGGTATCTACTTCACCCGCTTTCG (SEQ ID NO. 509) CCCGTACAAGAAAAACCACTAGGCCACCATCGAGTCCAAGAACAACCACCTGGTCCGCAAGTACGCGTTCTACTACCGCTATGACACCGCCGAGGAACGCGCCGTG CTCAACCGGATGTGGAAGCTGGTCAACGACCGCCTCAACTACCTCACCCCGACCATCAAACCGATC Clone Rv375 :::::::::::::Rv375SP6.seq::::::::::::: CTCAAGCTTGGGTGTTGCCGATCACCGGAAGCCNCATGATCAGCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTA (SEQ ID NO. 510) ATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACAACGCTGATTGAATCNAGTTCCANGTCCAGCGGGT :::::::::::::Rv375T7.seq::::::::::::: TNAACAGCTCGCGGCAGCCCACGACCTGCTGCGTCGGATTGCCGGCGGCGAGATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCTGGCCCGCAACGAANGA (SEQ ID NO. 511) CTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGNNNNGTCGGCAAGCCCGGCAGTNGCCAAA CCCAGCGTGATCANGCTCGGCTCGCGAGTTCGGCGAANAAGTGGCTCGCCTGATCACCTACCATCGGCCANGATCTGCGTGTCA Clone Rv376 :::::::::::::Rv376SP6.seq::::::::::::: GCCANCCGGCTTGGCGTCGACTCCCGTTCNGCACATCATACGGTCCCCGGTACTGTCCAACTGCGCCGGTGCGCTAGCCAAACGTCACGACTCTCAGTGATCCCAG (SEQ ID NO. 512) TTCGTGATCCGGCCGGTGGCGCCGCTGCGGCGGGGGCTNATNTACTTCGGACTNATTATCTCATCCAAAGGACACCGGGCCGGTGGCTGGAATCCCATGGTGCGAT CGGCCACACAN :::::::::::::Rv376T7.seq::::::::::::: CCGACCTGGTATCTTCCGATAGCGCGCGTTGATATCCGGTCTGATCTCCTGCCCTTAACGCCGGATCTCAGCAGGTCCCCATGCAAAGATCCGAGGTGTCCCNGAT (SEQ ID NO. 513) CTAGGGGTCCTCGTCCTCCAGATGATGGAGCAAGTCGGCCC Clone Rv377 :::::::::::::Rv377SP6.seq::::::::::::: CTCAAGCTTCGGCTCAGGCGGCGCTGCCGGTAACGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCAAGACACTGGCGCA (SEQ ID NO. 514) GGCTATCGCACCCGTTATCGGCTACAAACAAATCGCGGTATGC :::::::::::::Rv377T7.seq::::::::::::: CATCACCTGNTTCATGAACTGGAAGCACCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCAGCTCGGCC (SEQ ID NO. 515) GCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCGCGTTCTCC ACCGACCGGGCCCGGGTGTGGGGTGT Clone Rv378 :::::::::::::Rv378SP6.seq::::::::::::: AGCTTAGCTTCCCGCCCCGGCAATAGGGCTCCAGCTCATCCGGTGTGACCAGATAGGGGCCCAGGGTGATACCGCTGTCTTTGCCCTTGGCCTGTCCGATGCGCAG (SEQ ID NO. 516) CTGGCCCTCCAGCATCTGCAGGTCCCGTGCGGACCAGTCGTTGAAAATGGTATAGCCGATGATCGACCG :::::::::::::Rv378T7.seq::::::::::::: CCNGAACAGAAGCGGNGGTTCCTACCGCGGTGTGCGGCCGGCGCGATATCGGCCTTTTTACTAACCGAACCCGATGTGGGCTCCGATCCGGCGCGCATGGCATCGA (SEQ ID NO. 517) CGGCGACGCCGATCGATGACCGCCAGGCTTACCACCTT Clone Rv379 :::::::::::::Rv379SP6.seq::::::::::::: CTCAAGCTTGCGCGACTCGACAAGCATTCTTGACAGTTGTTTTGGCTCGGCATGGTTAGCCAAGGTTCTGCGGTCCCACCAGATCATCTTGGTCCGGTAGCGCTCG (SEQ ID NO. 518) TCCGGGTATGCTGCCGCCGGGATTCTCGCTGCTATTACTCCCCCCGAAGAACGCCACCGGTCCAGCGC :::::::::::::Rv379T7.seq::::::::::::: GCNAGGCGGTATAGCTTCCCGTCGTACCGGCGACCGCCAGCCGAGAAGCTCGTTTTCCCAGTGTTGCTGGGGATTCTCACGCTGCTGCTGAGTGCGTGCCAGACCG (SEQ ID NO. 519) CTTCCGCTTCGGGTTACAACGAGCCGCGGGGCTACGATCGTGCGACGCTGAAGTTGGTGTTCTCCATGGACTTGGGGATGT Clone Rv37 :::::::::::::Rv37SP6.seq::::::::::::: GTGTGGAACCGTGAGCGGATAACAATTTCACACAGGAAACAGCTNTGACCTTGATTACGCCAAGCTATTTAGGTGAGGCTATATTAATACTCAAGATTGCGGTCGA (SEQ ID NO. 520) GCACATCGGCCCAAGAACCGCCGAAGGCACGGCGGAACGCCTGCGGCACATGGGGCGACGACCAGCGGGTCGGACTTCTGGGCTGTCCAGCCGGATCGCGCCGTCG CGA :::::::::::::Rv37T7.seq::::::::::::: CACTGTCAGTACATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATCGTCGCCGGCGGTCATGGCGTCACCCTACCCAAGCCGAACGCGAAACGAGAACGTGTT (SEQ ID NO. 521) CCATTATTAGGGTGTGAGCACCAATACCAGATTGCTCACCAGGAACTCACGCAGCACCGGGACGGATGTCAGCCACCACGCCCATCTGGGGTGGTAGCGGGGAAAT ACGGCTAACGCGGCTCCGGTGCCGGCAGCCCAGCGCAGACCCTCGGCGGCGGACACGGCAAACAACGACGACCCATAGTTGTTCTTTGCCGGATGGCCGTGTTTGC GGACATATCGGGCGGCGGCGCGGGCGCCGCCGAGGTAGTGGCTGAGGCCCATCTCGTGCCCGCCGAATGGCCCCAGCCAAACCGTGTA Clone Rv381 :::::::::::::Rv381SP6.seq::::::::::::: CTCAAGCTTTTACGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCANCCTCTCGTCGGCGGTCGGGT (SEQ ID NO. 522) GCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACNAACGAC :::::::::::::Rv381T7.seq::::::::::::: CTCAGAAGCCGCTAGCTGGTAGAGTCGCTGACCGGTGCACGTGGCGNCAATGTGCGCTGCCGGTTCGCG (SEQ ID NO. 523) Clone Rv382 :::::::::::::Rv382SP6.seq::::::::::::: CTCAAGCTTGCGCTCATCAAGCGCGAACAGCAGGGCGGTCGGCTGGTCGCCATGACGGGTGACGGGACCAATGACGCACCCGCGCTCGCGCAAGCCGATGTCGGGG (SEQ ID NO. 524) TGGCNATNAATACCGGCACCCAGGCGGCCCGGGAAGCCGGCAACATGGTCNATCTCCACTCC :::::::::::::Rv382T7.seq::::::::::::: ACTTCTATTTCGACTGGTGTGCTGTGGCGCGATCCGACTGCCGGCGTGGTCAAGGCCGGCCAGTTGTGGGATNCCACAGGCAC (SEQ ID NO. 525) Clone Rv383 :::::::::::::Rv383SP6.seq::::::::::::: GCTTGTCGTATTCCGTGGCACTGTCAGACATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATCGTCGCCGGCGGTCATGGCGTCACCCTACCCAAGCCGAACG (SEQ ID NO. 526) CGAAACGAGAACGTGTTCCATTATTAGGGTGTGAGCACCAATACCAGATTGCTCACCAGGAACTCAC :::::::::::::Rv383T7.seq::::::::::::: CGATATTCGTCGGCCGCGTTGTCTCGACTGGGTCGCGT (SEQ ID NO. 527) Clone Rv384 :::::::::::::Rv384SP6.seq::::::::::::: GACCTCGGCCACCAAGCCGGACGCGACCGTCGAGGTGGCGATCCGGCTTGGCGTCGACCCGCGTAAGGCAGACCAGATGGTCCGCGGCACGGCCANCCTGCCACAC (SEQ ID NO. 528) GGCACTGGTAAGACTGCCCGCGTCGCGGCN :::::::::::::Rv384T7.seq::::::::::::: CCGGAAGTCTAGGGGACGACCTACTCAGCGCAAAATGTCGCTAATGTGAGTCCGCCCCACCAGGGCAGATCAACCCATGTCGATGATGACCTACCCGGATACCGGA (SEQ ID NO. 529) TTGGCGGT Clone Rv385 :::::::::::::Rv385SP6.seq::::::::::::: AGCTTCAGTTCCTCCACGACGCGTTCCCAAATGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGNAACGCTGGGCGGATT (SEQ ID NO. 530) GGCCCTGCCGCTG :::::::::::::Rv385T7.seq::::::::::::: CCGCCTACGGGTCGAACATGCATCCCGAGACCGATGCTCGAGCGCGCACCCCACTCGCCGATGGCCGGAACCGGCTGGTTACCCGGGTGGCGGCTGACC (SEQ ID NO. 531) Clone Rv386 :::::::::::::Rv386SP6.seq::::::::::::: GCGGCTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACGCCCGACCAGCCGATGCTGGAGGCCTACACGGCCCTTGGTGCGC (SEQ ID NO. 532) TGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCNTTGGTNACCGGCAATACCTACCGCAGCCCGACCCTGCTGGCAAAGATCATCACCACGCTCGACGTGGTTAG CGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGAGCTGGAACACCGCCAGCTCGGCTTCGAGTTCGGCACTTTCAGTGACCGGTTCAN :::::::::::::Rv386T7.seq::::::::::::: GCCTTTCCGCACAATCTGTACCCCAGGACCNTCTAAAAAATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCA (SEQ ID NO. 533) TTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCANTNNTGTCGGTCCCACGATGACCCAGTA CTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATT GTTAACCTGG Clone Rv387 :::::::::::::Rv387T7.seq::::::::::::: GCAGACCAACAAGATGCATCGGGATCATACGCCGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCCCAC (SEQ ID NO. 534) Clone Rv388 :::::::::::::Rv388SP6.seq::::::::::::: CTCAAGCTTGCCAAAGAGACCTCGTCCACCAAGCNGGACGCGACCGTCNAGGTGGCGATCCGGCTTGGCGTCCACCCGCGTAAGGCANACCANATGGTTCGCGGCA (SEQ ID NO. 535) CGGTCAACCTGCCACACGGCACTGGTAANACTGCCCGCGTCGCGGTATTCGCGGTTGGTGAAAAGGCCGATGCTGCCGTTGCCGCGGGGGCGGATGTTGTCGGGAG TGACAATCTGATCGANAGGATTCAGGGCGGCTGGCTGGAATTCGATGCCGCGATCGCGACACCGGATCAGATGGCCAAAGTCGGTCNCATCGCTCGGGTGCTGGGT C :::::::::::::Rv388T7.seq::::::::::::: CCACGGCGTGGATCAAGGTACCGGCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGATGTCGGCGTTAGCGCCGGATTCCACCACATCCCCTTGCGAAAG (SEQ ID NO. 536) TCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCNTACTCGATGTGCGCGACCTTGGCGTTG ACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTGGTAATCCGGCCATGCGCGTTGCGTC Clone Rv389 :::::::::::::Rv389SP6.seq::::::::::::: GGCGGCTGCGTCGGCGAGATGATCGCCCGGTGCCACCCCGATCCGTGCCTCGGTCAGCGCCAACGTGCTTTCCGGTCCGGCGACCACCATGTCGCATGCGCCGAC (SEQ ID NO. 537) :::::::::::::Rv389T7.seq::::::::::::: GCAATCGCCTTGGCGGTCGCCGGGTTGTCACCGGTGATCATCNCGGNGCGGATGCTCATNCGGCGCATTTCGTCNAATCGTTCCCGTATGCCCACCTTGACGATGT (SEQ ID NO. 538) CCTTCATATGGACCACGCCGATGGCCCNCGCGCTNCTG Clone Rv38 :::::::::::::Rv38SP6.seq::::::::::::: CCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCA (SEQ ID NO. 539) AGCTTCCACATCGGTATGCCAAAGCATTGCGCCGCTATCGATTTCGCGCTGGCATCGCCAAGGTGGACTTCTTGCTCAGCGACGAGATCCCGTGGTCGGATCCGCG GCTGCGGCGGGCTGCGACCCTGCATCTCGGCGGCACCCGTGACCAGATGGCGCGCGCCGAGGCAGACGTCGCGGCGGGACGCCACGCCGACTGGCCGATGGTGCTG GCCGCGTGTCCGCACGTCGCCGACCCCGGCCGCATCGACGAAACCGGCCGCCGTCCGTTCTGGACCTATGCCCACGTGCCGTCGGGGTCCACGCTCGACGCGACCG AGACCGT :::::::::::::Rv38T7.seq::::::::::::: CGCGTCCACCGCAGCGTGAGATTGGTGGCGCCATTCGTCGTGGTGTAGCTGCTGTTGGCGGCGTCGCCGTATTGTGCGGGCCAGCCTTGTGCGGGGGCCGCTTCTA (SEQ ID NO. 540) CCCACGAGTCGGCACTTCCGCAACCGCCCAGCTCGACCGCGATTACGGCGGCCGCAACGGCCGCCGGAAGGCGTCTCGCAAGCGCCTTATCCTTTCGCAGGTTCCC AGATCCTTCCGCTACGTGGGTCGCTCATCGGCGGGCCCGGCCGAATGAGTACAGGTGAGGGTAACCGCTACAAATGAAGTTGGTCAGTGCTGGCCAACTGTGTAAT GGTTGCCCGGCTCGGGTCACCACGTACATTCTGGCAAGGCGGGCGAGATTCGGTTCCTCGCGTCCTTGGCCGGTGGCGGTTCCCGGTTGTCCGTGGGCGTGTCGTG TACGTGGTGTAAGTGTCGTGAACTCCTCAGTTTGGGCT Clone Rv390 :::::::::::::Rv390SP6.seq:::::::::::: CTCAAGCTTGCGCTGGATCTGGCGGCTGAGCCTGTTCTTGGGCAACATGCCGAGGGATCGCCTTTTCCACCACGCGGTCGGGGTGGCGTTGCATTAGCTCACCGAT (SEQ ID NO. 541) GGTGCGCTTGTGCAGGCCGCCGGGATACCCCGAGTGCCGGTAAACCATCTTGTGCTGCAGTTTGTCGCCGCTGATGGCGACCTTGTCGGCGTTGATCACNATGACN AAGTCACCGCCATCGACATTGGGGGCGAACGTCGGCTTGTGCTTGCCGCGCAGCAGGTTGGCCGCCGCGACGGCAAGGCGGCCAANCACCACGTC :::::::::::::Rv390T7.seq::::::::::::: TTTGGGATGGGCAAAAAGGCGAAGCNCCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAACGTACGGCGTTTC (SEQ ID NO. 542) AACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGGTAGTCGCCGCCC GGGCGGCTACAGTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCGACGCAACGGTTCCTACACGGCGATATGTTCGCCTCGCTGCGCCGGTGGACCGG TGGGTCTATCCCGGA Clone Rv391 :::::::::::::Rv391SP6.seq::::::::::::: CTCAAGCTTCGTCATAAGACCATGGTGCGCTTTCTTTCACCCGTCCANAGTCGGGGGCATCCGCACCGGCTCGCATCGCATCATCCTCCCACGACGGGCCGCTCAT (SEQ ID NO. 543) CAGCTTGGGCCATTTCAATGTACTTGATACCCCGCGCTGCGGGTAGGCCACTGCNACAATTCAAACACGGTGTCACACGGTGAATANTGTCNANATGGGCTCTGAT CAACCGTCNCAAACCCGGTTTC :::::::::::::Rv391T7.seq::::::::::::: GAATTCTGCGTGCACCGCTATGGGTTGCAGCAGCGGCTGGCGCCGCACACCCCACTGGCCCGGGTGTTTTCGCCCCGAACCCGGATCATGGTGAGCGAAAAGGAGA (SEQ ID NO. 544) TTCGCCTGTTCGATGCTGGGATTCGCCACCGCGAGGCCATCGACCGATTACTCGCCACCGGGGTGCGAGAGGTGCCGCAGTCCCGCTCCGTCGACGTCTCCGACGA TCCATCCGGCTTCCGCCGTCGGGTGGCGGTAGCCGTCGATGAAATCGCTGCCGGCCGCTACCACAAGGTGATTCTGTCCCGTTGTGTCGAAGTGCCTTTCGCGATC GACTTTCCGTTGACCTACCGGCTGGGGCGTCTGCACAACACCCCGGTGAGGTCGTTTTTGTTGCAGTTGGGCGGAATCCGTGCTCTGGGTTACAGCCCCGAACTCG TCNCGGCGGTGCGCGC Clone Rv392 :::::::::::::Rv392SP6.seq::::::::::::: GCAGTTGGGAATCGCTCTGCAGCAAAGGANTATTCTGCGCGACGTTCGAGAGGACTNTTTGAATGGACGGATCTACCTGCCGCGCGACGAGCTGGACCGATTAGGC (SEQ ID NO. 545) GTACNCCTCCGCCTGGACGACTCCGGGGCACTCGATGACCCCGACGGACGGCTCGCGGCACTGCTGCGGTTCANTGCCNACCGCGCCGCANACTGGTATTCGCTGG GACTGCGGCTGATTCCACACCTCGACCGCCGCAGCGCTGCCTGCTGTGCGGCCATGTCTGGCATCTACCGCCGTCNGCTCGCCTTGATCAGACCATCGCCGGCGGT CGTCTACCATCGGCGAATCTCTCTGTTCGGGACTGAANAANGCCCAAGTGGCGGCGGCAGCACTGGNCTCTTCGGTAACCTGCNGACCGCCCATTGGACCGCTACC G :::::::::::::Rv392T7.seq::::::::::::: TTGATCTGGACGTCTGAGACGGTGATCGGNCCGAACCTGAATTGTCCGGTAATGCCCAGCGCAGAAAGCANGGTGGTGGCCGGGGCGGTGAANCCGGCGTCGGCGG (SEQ ID NO. 546) CACCGTCGAAGTCGATGTGGATTGCCGGAATGGGGATGTCCGGCACGGCGAAGCCGTAGTTCGCTTGTCCCGTGAGGCCCANGTGGATGGGGGGAAGGATCGTGGT GTCCGGGATGATAATGGGGCCGATGCCGCCGGTTGAAGTCCAGTGGATCGGGAATTCGGGAATCGTGATGCCGACGTTCAGGCCGAACAGGCCCTCCAAGTTGCCT CGCCACNAGATGCCGTTGCTGAAGTTGCCCGACATGAGGGCGCCGGTGTCCACATTGCCCGAATTGGCGACGCCGGTGTTGGC Clone Rv393 :::::::::::::Rv393SP6.seq::::::::::::: CACGTAGGCGCCGTCCATAAATNACTCCGCCGCGCTTCGCACATCCTCGTANCGATCCTTGGCGAGCAGGTCAACCGGGCGCTGCCCGTCNAGGAGCCGGTTTTTG (SEQ ID NO. 547) GCGTGCAGCCACTGGCCGACACCTCGGGGGGTAAGCGAATCCGAGAGCAGGAGGACNAGGTCACGAANCTGCGCCAGCCGGTCGTACCGCTCAGGGCGGATGTCGC CGGTCCGCCACCCGCGTACCGCCCGATCGGACACCTGTATGACCGCGGCGACNTCGACCTGGGTGACGCCGAAGGGTTTCAGGGCATCNACNATCTCGCTGGCCTC GACCGCCCGGTCCAGGGTGACCGCCATCGTGGTTCCTCCGCAACTTCCGGTTCTACTACCGTAAACGCTACCG :::::::::::::Rv393T7.seq::::::::::::: CGGGGAACGGTCCTCGCACACCTGGTTCGTGTTGCGGGAATTACTCGGACANCAAAACGTCAAGAACTACGACGGCAGTNGGACAGAANACGGCTCCCTGGTGGGC (SEQ ID NO. 548) GCCCCGATCGAGTTGGGAAGCTGATATGTGCTCTGGACCCAAGCAAGGACTGACATTGCCGGCCAGCGTCGACCTGGAAAAAGAAACGGTGATCACCGGCCGCGTA GTGGACGGTGACGGCCAGGCCGTGGGCGGCGCGTTTCGTGCGGCTGCTGGGACNCCTCCGACGAGTTCACCGCCGGGAGGTCGTCGCGTCGGCCACCGGGCGAATT TCCGGTTCTTCGCCGCGCCCCGGGATCCTGGGACCGCNGGCGCGCGCTGTT Clone Rv396 :::::::::::::Rv396SP6.seq::::::::::::: CTCAAGCTTTGTCCGACAAGCGTTCCCGGGCGGTCAGCAAGCGAACGTCGGTTGGCCCACTGCGGGTCGATATTGCCGCCAGGGA (SEQ ID NO. 549) :::::::::::::Rv396T7.seq::::::::::::: CGTCAGCACGGCGACGTCGCGNTACGCCGAGCAGTTACACAATCGCTCTGCAGCAAACCAATATTCTGCGCGACGTTCGAGAGGACTTCTTGATTGGACTG (SEQ ID NO. 550) Clone Rv39 :::::::::::::Rv39SP6.seq::::::::::::: CTGCATCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAA (SEQ ID NO. 551) TACTCAAGCTTCGCGCAGCGGCGGGTTGACCCGGTTCACGCCGTCATAGCTGGCCAATCTGGCATCGTCGATCANCATGTGGTGGGGGGTGACCTCGGCGGTGATC GAAATACCCTGGTCCTTATCCCATTTCAGGATTTCGACGGTGCCCGCGGCCGACGCGTGACAGATGTGCACCCGGGCGCCGGCGTCACGGGCCAGCAAGGCGTCGC GGGCGACGATCGATTCCTCGGCGGCCCGCGGCCATCCCGCCAGGCCCAGCCGCGCCGCCATGGGTCCCTCGTGCGCGACGGCGCCGACCGTCAGCCGGGGCTCCTC GGCGTGCTGGGCGATCAGCACGCCCAAACCGGTG :::::::::::::Rv39T7.seq::::::::::::: CCGACGCGCACTACGTGCTGGTGTCCACCCGCGACCCGCACCGGCACGAGCTACGCAGCTACCGCATCGTCGATGGCGCTGTCACCGAGGAACCTGTCAATGTCGT (SEQ ID NO. 552) CGAGCAGTACTGAACCGTTCCGAGAAAGGCCAGCATGAACGTCACCGTATCCATTCCGACCATCCTGCGGCCCCACACCGGCGGCCAGAAGAGTGTCTCGGCCAGC GGCGATACCTTGGGTGCCGTCATCAGCGACCTGGAGGCCAGCTATTCGGGCATTTCCGAGCGCCTGATGGACCCGTCTTCCCCAGGTAAGTTGCACCGCTTCGTGA ACATCTACGTCAACGACGAAGACGTGCGGTTCTCCGGCGGCTTGGCCACCGCGATCGCTGACGGTGACTCGGTCACCATCCTCCCCGCCGTGGCCGGTGGGTGAGC GGACACATGACACGATACGACTCACTGTTGCATGCCTTG Clone Rv3 :::::::::::::Rv3SP6.seq::::::::::::: TGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT (SEQ ID NO. 553) ACTCAAGCTTGCCGGGAGGGTGCATGGCCGACTCGGATTTACCCACCAAGGGGCGCCAACGCGGTGTCCGCGCCGTCGAGCTGAACGTTGCTGCCCGCCTGGAGAA CCTGGCGCTGCTGCGCACCCTGGTCGGCGCCATCGGCACCTTCGAGGACCTGGATTTCGACGCCGTGGCCGACCTGAGGTTGGCGGTGGACGANGTGTGCACCCGG TTGATTCGCTCGGCCTTGCCGGATGCCACCCTGCGCCTGGTGGTCGATCCGCGAAAAGACGAAGTTGTGGTGGAGGCTTCTGCTGCCTGCGACACCCACGACGTGG TGGCACGGGCAGCTTTAGCTGGCATTCCT :::::::::::::Rv3T7.seq::::::::::::: GGAAACACCGNCGCCGTCGTGGCCACCAACACCGCGACCAGCACCGTGACCCGGACCGGGGTGCCGCGCGAACCGGTCTTGGCCAATTGCCGCGGCACCAAGCCGT (SEQ ID NO. 554) CGCGCGCCATGGCGAACAGCACGCGGCATTGCCCGAGCATCAACACCATCACCACCGTGGTAAGCCCGGCCAGCGCGCCGACGGAGATGATGCCGCTGGCCCAGTA CACCCCGTTGGCCTGGAACGCGGTGGCCAGATTTGCCGGCCCGCGGCCCGGTACGGTCCGCAGTTGGGTGTATGGAACCATGCCCGACAGCACCACCGATACCGCG ACGTAGAGAAGGGTCACGACCCCCAGCGACGCGAGAATCCCTCGAGGGACGTCTCGTTGAGGACGCTTGGTCTCCTCGGCCATGGTGGCCACGATGTCAAACCCGA TAAACGCGAAGAACACGATCGATGCCCGGCCAGCACGCCGTA Clone Rv40 :::::::::::::Rv40SP6.seq::::::::::::: CCTGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGA (SEQ ID NO. 555) ATACTCAAGCTTGTCCTCGGGCGTGGCCTCGGCCAAGAAATCGTCGACGCCGGCCTCCTGTGCAATCGCCTTGGCGGTCGCCGGGTTGTCACCGGTGATCATCACG GTGCGGATGCTCATTCGGCGCATTTCGTCGAAGCGTTCCCGTATGCCCACCTTGACGATGTCCTTCAGATGGACGACGCCGATGGCCCGCGCGCTGCTGTTATCGG TCCATTCCGCAACGACTAGGGGTGTCCCCCCGCCGGAGCTGATGCCGTCGACAATGGCACCCACCTCCTCAGTGGGGTGGCCACCGTGATCGCAAAACCACTTCAT CACCGCAGCCGCGGCACCTTGCGGATCCGAACGGATGCGCTC :::::::::::::Rv40T7.seq::::::::::::: TTCGTTCGATGGCGCCGCCCCGGCTACGGTTTGACCTGTGGGTGTCGAATTGGGGTCAAATTCCGAGGTCGGCGCGCTAAGAGTGGTCATCCTGCACCGCCCGGGG (SEQ ID NO. 556) GCCGAACTGCGCCGGCTCACACCGCGCAACACCGACCAGCTGCTGTTCGACGGCCTGCCCTGGGTATCCCGCGCGCATGACGAGCACGACGAATTCGCCGAGCTGC TGGCTTCCCGCGGTGCGGAAGTGCTGTTGCTGTCGGACCTGTTGACTGAGGCACTACATCACAGCGGGGCCGCCCGCATGCAGGGGATCGCCGCTGCCGTCGACGC ACCGCGGCTGGGACTGCCGCTGGCGCAAGAACTTTCGGCCTACCTGCGTATCTCGACCCAAGCANGTTGGCGCATGTGCTGACGCCGGCATGACTTCAACGAACTC CCNTCCGACACGCCGAACGAAGTGTCGTTGGTGTTGCGTATGC Clone Rv412 :::::::::::::Rv412SP6.seq::::::::::::: GCGGCGAGTGTGGTGGGTGCCGAACACGAATCCAACGACGCACTGGCGGAGAGATACCACTTGCTGTACTGGAAGCACGTGCTGATGATCTCCCGTGGAATGTGCC (SEQ ID NO. 557) TCGCCGCCGTCTATCGAAAACAGTGAGCATGCTGCG :::::::::::::Rv412T7.seq::::::::::::: CAACCGCGCTCGGCGCGTCTGGGCCTTCCGCCGGCTCCGCCGACAATTCTATCTCTGGATCAGCGGGGCTCTCCGGGCCGGCCTCCGCGAACTCAACAGGCCGCGC (SEQ ID NO. 558) CTTCCGGCCGAAACATTCCCTAGCCATATATGATCGCACCTCGATACACGATCTGGCGGCAACACCGCAAAGCGTCCGACGGGCCCAACCTCCGCAATTCAGGTAT CCGGG Clone Rv413 :::::::::::::Rv413SP6.seq::::::::::::: GAAGGTCGGCGAAGGTGTGGCTGGNTGCCGATCACGAATCCAATGATGCAGTGGTCGGAAGATATTAGCCACTTGCTGTTCTGGAGACAGGTGCTGATGATCTCCC (SEQ ID NO. 559) GTGGAATGTCCCTCGACTCCGTCTATCGAAATCTGTGAACA :::::::::::::Rv413T7.seq::::::::::::: TCCTGCGCTCTGGGCCATTCTCGGGTCTGCCGACAATTCTATCTCTGGATCTGTGGGGCTCTCTTGGCCGGCCTCNGCGATCTCTTCANGGCGCGCCTTCCGGCCG (SEQ ID NO. 560) AAACATTCCCTATCCATATATGATCGCACCTCTATACACCGTTTGGCGGCAACACCGCAAAGTGTCTGTCG Clone Rv414 :::::::::::::Rv414SP6.seq:::::::::::: AGCTTTACGCTGGCGTATCAGCGTTGGGGCCGCTGCCATTTCGGTCGCCCAACGCGTTGCCAGCTCCCTGCGCTGTCAGGGCTTGCGCGCCAAACTGGCCACCGCA (SEQ ID NO. 561) ACAAACTTGGCTGAGCTTGATC :::::::::::::Rv414T7.seq::::::::::::: CTCTATCTGGCGTCACATTCGCAATCTTTAGATTGCAGATATCGATAAAATCACCCGCGCGACAAGACCGCCATGTCATCCTTTCGATGTTATTTCGCCGGCCTGG (SEQ ID NO. 562) GGAAAGCGCAACGACGTTGCCTACACGTTCCGCCGT Clone Rv415 :::::::::::::Rv415SP6.seq:::::::::::: AGCTTTNCCTTGCATCTGCACCCCGATCCACGTCAGCCACGTCGGCGTTCTCCACCAAGAAGTTGCGGGCATTCTCCTTGCCCTGGCCGAGCTGCTCGCCCTCGTA (SEQ ID NO. 563) GGTGAACCAGGCACCCGACTTGCGGATGAGGCCCTGATCCACACCCATGTCGATCAGCGAGCCCTCCCTGCTGATTCCCTTGCCGTAGAGGATGTCGAACTCGGCC TGCTTGAAGGGGGGCGAACAGTTGTGCACGACAACCCCTTCGGCGACGAGGGTGTGCAGTTCCTCGACCTCGAGGTCGAACGTTCGTGCCCGCCGCGTTGGCAGCA CTTCTCGGATCACGGAATAGCGGANTTCTTCCGCCAGCATGTCGTGCAGGAATTTGTCATCCAGGGCATCCGCGAGCGCCTGCACGCG :::::::::::::Rv415T7.seq::::::::::::: ACTGTCNAGGGAATGCTTCGCAGCATCTACCTGCAGTCGCTTGTGCATAAGCGGACGGCCCNACCTGTTCGTGTTCCGGGACACCAGACGCGGGAGCACCGGCAGT (SEQ ID NO. 564) ACGGCGAAAGGTTTGAGCGGAAGGAGTTGCGCAAATCGGGGCGCCCCAACACCCGTCCGCAAGACGCGGTCAACGACCTGTTTCAGGCGATCAGGGTCACCGACTC ACCTGCACTGAGAACAAGCGATCTGCTGATCTGCCAGAAGATGGACATGAATGTCCACGGCAAGCCTGATGGCCTGCCGCTCTTCCGGGAATGTTTGGC Clone Rv416 :::::::::::::Rv416SP6.seq::::::::::::: TGAATTATGATCCCGACACAACTGCATCANTTTAGCCGCGTCGNGATGCTATCCGCCGACGGTTTGGANCNGGTCCGTGTCGTTCGTGTTGATCTCACCCGAAGTT (SEQ ID NO. 565) GTGTCCGCCGCCGCCGGGGATCTAGCGAACGTGGGATCGACAATCAGCGCCGCCAACAAGGCGGCAGCGGCTGCGACCACGCAGGTGCTGGCCGCGGGCGCCGATN AGGTGTCAGCGCGCATCGCGGCGCTGTTTGGTATGTACGGCCTGNAATATCCGGCGATCAGTGCGCAAGTTGCCGCGTATCACCANCAGTCCGTGCAG :::::::::::::Rv416T7.seq::::::::::::: AACGGGGACCNCAAGAAACCATTCAANAACGAGGGGTCGTCACCAACGTCGAAACCGACGGTTGCCAGCCGGCCCACGATATTGCGTGCTCGAGGGTCCGCTGTAC (SEQ ID NO. 566) CCTCACCGAACGTGAGTCCCACACCGCGGAGGCGGGCGACTCTGGCGTCGTTAGCAGCCGAGCTCAAGGTGTCCCGCACCACTGTCTCGAATGCTTTTAACCGACC GGATCAGCTCTCCGCCGATCTACGTGAACGAGTGCTTGCCACGGCCAAGCGACTGGGCTATGCCGGACCGGATCCGGTGGCGCGATCGTTGCGGACCCGCAAAGCC GGTGCGGT Clone Rv417 :::::::::::::Rv417SP6.seq::::::::::::: AGCTTTGGAGCCNCNCCGANCCNCCGGTACGCCCCGCCACCGCCGTACCCGGCACCCGACCCCTTTGAGCCGTTCGCCGTGGCCGCGGTGGANCTGGCCGACGAGG (SEQ ID NO. 567) GACTGATCGTGCTGGGCAAAGTGGTCGATGGCACGCTGGCCGCCGATCTGAAGGTCGGCATGGAGATGGAGCTGACGACCATGCCGCTGTTCGCCGACNACGACGG TGTGCAGCGCATCGTCTACGCGTGGCGGATCCCATCGCGCGCCGGCGACNATGCANAGCGCANCGATGCTGAGGAGCGGCGCCGATGAGGATGAGCGCGCCGGAAC CCGTTTACNTCCTGGGTGCCGGTATGCACCCGTGGGGGAAATGGGGTAATGACTTC :::::::::::::Rv417T7.seq::::::::::::: TTCTCNCATCGTTCGTACTNNGATGGGACGCTGCTGCCCGAGGCGATCCTGGCCAACCGGCTCTCGCCGGCGCTGACCTTCGGCGGGGCGAACCTGAACTTCTTTC (SEQ ID NO. 568) CGATGGGCGCTTGGGCCAAACGTACCGGGGCTATCTTCATTCGGCGTCAGACGAAAGATATTCCCGTCTACCGCTTCGTATTACGTGCTTACGCCGCGCAGCTGGT GCAAAACCATGTCAACCTCACCTGGTCGATCGAAGGGGGTCGGACCAGAACGGGCAAGCTACGGCCACCGGTGTTCGGGATCCTGCGTTACATCACCGATGCGGTC GACGAAATCGACGGTCCCGAAGTGTATTTGGTGCCGACCTCGATCGTGTACGAACAGCTGCACGAAGTGGAAGCCATGACCACCGAAGCCTATGGCGCCGTGAA Clone Rv418 :::::::::::::Rv418SP6.seq::::::::::::: TTCTTCCGGGTACCGCTGATCGGCGGCACCATCACGCACCCGGTGCAGGGCGAGGCGGCCGCCGGTGTGGTGTTGCTACGGCCGGCCAGCCCGGGTACCGGTGTGA (SEQ ID NO. 569) TCGCCGGTGGTGCGGCCCGCGCGGTGCTGGAATGTGCGGGGGTGCACGACATCTTGGCCAAGTCGCTGGGCAGTGACAACGCGATCAATGTGGTGCACGCCACCGT GGCCGCGCTCAAGCTGCTGCACCGTCCGGAGGAGGTGGCGGCGCGCCGCGGTTTGCCAATAGAAGACGTCCCCCCGGCCGGGATGCTG :::::::::::::Rv418T7.seq::::::::::::: GTCGAAAGTGACCATCTCTACCTTGAGTGCCATACCGCCCGACCCTATGCCTCGGATAGCTCGGCGGAAAGAAACGCTTGCAGTGCCGCCGAATAGGCGGCTACGT (SEQ ID NO. 570) CGTGAGCGCCCATCAACTCTCGCGCGGAGTGCATCGCCAGCTGGGCGGCGCCGACGTCGACCGTGGGGATTCCGGTGCGCGCCGCGGCCAACGGCCCGATCGTCGA CCCGCACGGCAGATCGGCGCGATGTTCGTAACGCTGCATAGGCACTCCCGCGCGCTGGCAGGCCAGTTGCGAAACGCCCCCGCCGGGTGCCTTCCGTCGGTTGGCT TTACCGCAAATTTGGGGTTGCCCCT Clone Rv419 :::::::::::::Rv419SP6.seq::::::::::::: AAAGCCACGGAAACGATTGCCTACTGCCGAATCGGGGAACGGTCCTCGCACACCTGGTTCGTGTTGCGGGAATTACTCGGACACCAAAACGTCAAGAACTACGACG (SEQ ID NO. 571) GCAGTTGGACAGAATACGGCTCCCTGGTGGGCGCCCCGATCGAGTTGGGAAACTGATATGTGCTCTGGACCCAAGCAAGGACTGACATTGCCGGCCAGCGTCTACC TGGAAAAA :::::::::::::Rv419T7.seq::::::::::::: TTTCGCCACCGCNAGGTCGTGCGCGTTCCAGAAAAGCGTGGTTTCGCCGGGCGCGAGGATTCGACGGTCCAACTGACCAGCCGGTCCCGCCACCCGTTAGGCAGGA (SEQ ID NO. 572) TCGCGGTGTCTATATGTTCGCCCTCGGCATAAACGCCATTGCTGCGGTGAAAATCGGACATCTCGCCGATTGCCACGTCTACATGATCCGCTTTGTCCCGCGCCGG GTCGTTGACAAACGCGATGTCNGCCTCCTGGGAAGCGGTGGC Clone Rv41 :::::::::::::Rv14SP6.seq::::::::::::: TCGCCAAGTGGATTCGTGCTCACCNACGAGATCCGTGGTCGGATCCGCNGCTGCGGCGGGCTGCGACCCTGCATCTCGGCGGCACCCGTGACCAAATGGCGCGCGC (SEQ ID NO. 573) CGAAGCAGACGTCTCGGCGGGACGCCACGCCGACTGGCCGATGGTGCTGGCCGCGTGTCCGCNCGTCNCCGACCCCGGCCGCATCNACCAAACCGGCCGCCGTCCG TTCTGGACCTATCCCACGTGCCNTCGGGGTCCACGCTCGACGCGACCGANAACGTAACCAGCGTCCTCGANCGGTTCGCCCCCGGCTTCCGTGACATCGTGGTGGC GGCCGCGCCGT :::::::::::::Rv41T7.seq::::::::::::: GTACCGTCACCATGATCGCCCCCATCGGCATCGGTGAGCTGATAGATCCCAGCCGGTTTCGCCAACCCCGGAGCGATCTTGGCGCGCTGCTNGTNGTCNCTGANAC (SEQ ID NO. 574) NTAGCCACCAACAGAGCCCGGTGTGCGACAAGANGACTGATCGGATCTCTCCGGACACNTCGAGGGGGTCNTCAGGAGNCCGGGCGCCACCCCGAGGTAAGCCTCC GCCCAGCCTCACACCGCGACCGGGTATCNCAAGTCGCGCAATAANCCCACCACCTCCTCGGACCCCACGTTGTATGCGGCTGGGT Clone Rv42 :::::::::::::Rv42SP6.seq::::::::::::: ATACTCAAGCTTAGACCTCACTGATGTGGCGGGACGCGGGAGATAACCGCGGTTCGAGCCGTTCAACAGTGGTGGTTCCCACACCAGTTGTTTGCCTTTGCGAAGT (SEQ ID NO. 575) AAAGCGATTCGATTTGCTCGAAAAGAGGGCTGGCTGCTCGTGAGGGACATCCATGGCCGATACCTCAGCGATCTCAACGGTCAAGCGACTGCATGTTTGGCGCAAG GTATCGCTAAGCATAGGTTCGTGACGGATTTGACAGCAAGAGCTTTCCAAAGATTGCTGTCCACATANTGATTCGCATCTCTACACCTCTTCGCCGGTGCTGTCAA GAGCCATTCGAATCAGTTATCTCGCTCGTGCTTGGAANAAATTTTCCCAGCCTGCGTTGGACAAACCGCGTCGCCAAAGCGGT :::::::::::::Rv42T7.seq::::::::::::: AGCTTCCCGAGAAACAGTGCATTCCCTAAGCAGCCCGTTGTCACGCCGATGAGTGAAGAGTGCACGCAATCGCCGGAATCCGGCAAAGCCCTGCACAAGCGAAATC (SEQ ID NO. 576) AACCCGGAGGCTGACAAGGCAACGTCGGTGATCCGTACCGCCTGGTTGGACAAACGGCAGAAGGCGGCCTCGTCCGGTCCATCTACGCCGAGCACACTGGTGATAG CGCGCATCGGCATCGGTGCGGCCACGGTGGAGACGACGTCCGCGGGCGTCTGGGTCAGTAACCCGCCGACCAGTTCTCGGGCAAGCTGGTCGACCATCGGGCGCCA CGTCTCCAACGCGCCACGCGCCATACCTGGTGCCAGTTGCTTGCGCATCCGGGTGTGCGCCGGCGGATCGGACGTCGCAGAAACGCAGCCACCCCGTGAGAAGTGA CCCACGGCGCTGGACACGTGTCTGGTTAC Clone Rv43 :::::::::::::Rv43SP6.seq::::::::::::: CGGCCGGGATGTGCGCAATGGCAGGTTGTCGCCCGGCTTGATGTCGGCGTTAGCGCCGGATTCCACCACATCCCCTTGCGAAAGTCCGTTGGGTGCAATGATGTAN (SEQ ID NO. 577) CGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCTTGGCGTTGACACCATCTTTGTCATGGCGGC GAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCNGGTGGTAATCCGGCCATGCGCGTTGCGTCCACCGCGACCGTGCAGCGGGCGCACCAG CGACNTCTCCGGGGTTGACCGGGTGATCTCGGCGAAATCAGATACGCTGGCGCCGCGACGACCAGGCGTCGTGGGCTTGTACTTGCGAATTGCCATGGTCTAATCA GGTCTTTCTCTCACCTCTCGTCGCCGGGCTAGGGCGCATTGCCTGCTCCT :::::::::::::Rv43T7.seq::::::::::::: TAGCGGTGTAACCAACTCCCGGGTCACCACCCGCAAACCTCTTGCGGCAACAGCACCGTCGACGCGTCAACCGGGCTGCCCGGAATCCTGTGGATGGGCATCGAGT (SEQ ID NO. 578) GCATGGTCACGACGTCCCCGACGCGGCCGGTGGCAACGACAAGTGGCCCGGATGCACCACAAATGACGGCCGCACACCGGTGGGGACGGCCAGCACGAGAGCCGTG TCGCCGAAGTCGACGCTAATGCCGTAGGCATTGGCCGTCACAACAGGCGACGCCCCGCGTACCACCGAGTCCACGGNGGTTGGGCGGTCTCCTCGGCCAACCAGGC GTGAACCCGGCGGATCCGAATGCAGCAAGACCCGTGGGC Clone Rv44 :::::::::::::Rv44-2ndSP6.seq::::::::::::: CCATTGGTCGGTGTGCGCATACCANTACNACGCGCCGGGCACCTGACGCGGCGGCCGCAACCATTCGGTGGCCATCGCCATCGTCTGCCACCCGGTCAACGGACGC (SEQ ID NO. 579) ACCTTCTCCTGGCCGACCTAGTGCGCCCACCCGCCGCCGTTGCGTCCCATCGATCCGGTCAACATGAGCAGCGCCAACACCGAGCGGTACATGACATCTGCTGTGG AACCAGTGACANATTCCGCCGCCCATGATGATCNTCGACCGTCCTCCGGATTCGGTC :::::::::::::Rv44-2ndT7.seq::::::::::::: GCCGGCCTGGTCAAAGGGGCGTCCGAAGGANCCGGGCTGGGTAACAAGTTCCTGGCTCATATCCGCGAATGCGACGCCATTTGTCAGGTGGTGCGGGTGTTCGTCG (SEQ ID NO. 580) ACGACNACGTGACTCATGTCACCGGACGGGTCGATCCCCAGTCCGACATTGAGGTCGTCGAGACCGAGCTGATCCTGGCAGATCTGCAAACCCTGGAGCGGGCCAC GGGCCGGCTGGAGAANGAAGCNGCACCAACAAGGCGCGCAAGCCGGTCTACGACCCGGC Clone Rv45 :::::::::::::Rv45SP6.seq::::::::::::: GATCCACTGACCACGATGACATATCGAAATGCTCGACGATTCCGATGGCGATCAAGGCCACGATGCCCTGGCCGTTGGGCGGTATCTGGTGGATGGTGTACCCGCG (SEQ ID NO. 581) GTAGGTTCCCGTGATCGTGTCGACCCAGTCCACGCGATGGGCGGCGAGGTCGTCGGCACGCATCACCCCGCCGTNTGCCGCCGAGTGCGCCTCGAGTTTGGCGGCC AGCTCTCCCCGGTAGAACTCTCACCGTTGGTCGCCGCGATCTTCTCTANCGTCGCCGCGTGGTCAGGAAAGGTAAACAGCTCACCGGGTTTCGGCGCTCGTCCGCC GGGCATGAACGCATCTGCGAATCCGGGCTGGGATGCGAACAACGGACCTGTGCCG :::::::::::::Rv45T7.seq::::::::::::: TCTACTGCCGAATCGGGGAACGGTCCTCGCCCACCNGGTTCGTGTTGCCGGAATTACTCAGGACACCGAAACGTCGAGAACTACGAGCGGAGTTGGACANAATACC (SEQ ID NO. 582) GCTCCCNGGTGGGCGCCCCCATCGANTTGGGAAGCNGAAATGTGCTCTGGACCCCACCCAAGAATGACATTGCCGGCCGCCCTCCAACTGGAAATAGAAACNGTGA TCACCCGCCGCGTTCTTGGAAGGAATGGCATGCCCTGGGCCGGGCGTTCCTTCCGCTGCCGGACTCCTCCCACCAATTCACCGCCGAAGGCGTCCCGTCTGC Clone Rv46 :::::::::::::Rv46SP6.seq::::::::::::: ATACTCAAGCTTCTGTCACCGAAATCCCGCATGGGATAACGGGTTTAGATTTCGACAACGGGACCGTGTTTCTCAACAAGCCGGTCATCAGCTGGGCCGGCGACAA (SEQ ID NO. 583) CGGTATCTACTTCACCCGCTTTCGCCCGT :::::::::::::Rv46T7.seq:::::::::::: CTGGCTCAAGCGCTCGGCGCGCAGGTGAACTCGGACCGGCTCGACGTCGCCGAACGCGAGGCGGTGCTGGCCCACGCCGACGCCGTCGTCGCACATATCGGCACCG (SEQ ID NO. 584) TGCACAAGTCTACAACAACGCCGGCATCGCGTACAACGGCAACGTCGACAAGTCGGAGTTCAAGGACATCGAGCGCATCATCGACGTCGACTTCTGGGGCGTCCTC CACGGGCCC Clone Rv47 :::::::::::::Rv47SP6.seq::::::::::::: CCGCCCTCCGCATTATGGGTCAAGAACCATCGGGTCGGACTTCTGGGCTTCCAACGCTCGCGCCGTCCCN (SEQ ID NO. 585) :::::::::::::Rv47T7.seq::::::::::::: CCGTGGCACTGTCAGACATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATCGTCGCCGGCGGTCATGGCGTCACCCTACCCAAGCCGAACGCGAAACGAGAAC (SEQ ID NO. 586) GTGTTCCATTATTAGGGTGTGAGCACCAATACCAGATTGCTCACCAGGAACTCACGCAGCACCGGGACGGATGTCGGCCACCACGCCCATCTGGGGTGGTAGCGGG GAAATACCGCTAACGCGGCTCCGGTGCCG Clone Rv48 :::::::::::::Rv48SP6.seq::::::::::::: TACTCAAGCTTGTCCAAATATCGAAGCGTCGGGTCGCGAGGCTCGGTCGGCAGCTCCAGCAAAACCCGCTCCACCCCTAGATGCCGGTATCCCTCAAGGTCTTTAT (SEQ ID NO. 587) CCGCCGCTTCACCCCACTGGCACACGGTCACCGGCACGTCGCCCCCGGCCATGGCGCGCAACCGCTGAAGCGGACCCGACAGCCGCTGCGGTGATGGACTGATCGC GATCCACCCGGCATTGAGCCGGGCTATCCGCGGGAAGTTCGCCGGTCCCCCGCCCACATACAGCGGAGGATAGGGCTTTGTCACCGGCTTCGGCCAGCAGTAGATC GGATCGAAGTCCACATATGTCCCATGGAATTCCGCCTGCTCCTGCGTTCAGATCTCGATTATCGCGCGCAACCGCTCATCGATCACACGTCCGCGCACCGCAGGGT CCACACCATGGTTGGCGACTTCTTCGCGCAACCAGCCACACCCACGCCGAAACGAAACCGTCCCTGCG :::::::::::::Rv48T7.seq::::::::::::: CAGGCATCGAAGCTTGGCCAACTCCTCATCGGACTTGAAGGTGCCGTCCTCGTTGGCGGCCCTGCTCCACGGCACGTTGATGGCACCAGGAATGTGTCCGGGCCGC (SEQ ID NO. 588) TGGCTTTGTTCCTGCGGCAGGTGCGCGGGGGCCAGGATCTTGCCGGAGAACTCGTCGGGAGAGCGCACGTCGATGAGGTTCTTGACGTTGATGGCCGCCAGGACCT CGTCGCGGAATGCCCGAATCGTGTTATCCGGCGGGGANGCGGTGTAGGAAGTCACCGGCCGGCTGACCGGGTCGCTGGACAGCGGGCGTCCGTCGAGCTCC Clone Rv49 :::::::::::::Rv49SP6.seq::::::::::::: ATACTCAAGCTTCAAAACAGGCCTGTTGTGGGCGCACCCGGCTCGCCGAGTTCTGCACGCACCGCCTCAAGTGCGGCCCGCACCGCCGGCATCTCCCGGTCACGCA (SEQ ID NO. 589) GGGCCGCGGCCCGCGCCGCAGCGACGGCGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGGTCTCGGCGTCGTCCCGTTCACTAAT CGCGGTGCTCAGCAGCGTCTCGACAGCCACCACCCGAGTGGAGACCAGATGCNCCACCACGGACCGCAGCGATGCCAGTCACCTCACCCGTCC :::::::::::::Rv49T7.seq::::::::::::: CAGGCATGCAAGCTTTGCAGTTGCTGAGTAATGTCGGCCAACGTCACCACAATCGCGATGAATTCAATCATGCCGCCCAGGGCGGCCAACCCAATGGTGGCCGCGA (SEQ ID NO. 590) GCGGCAGCTCGATCGCAGCGCGGAGGTTGCCGGCCGCCAGTTGATTCACGAACAGGGTGAGGTCATAGGCGGGCAGGATAGTGACGAAGGCAAGACCTAGATCTGC CGTCGGAAGAAGAATCGAGTATCCGGTCGACACAACGGAAGCGAAAGTGTCCGCGATGTTGATGAGCGTCGCCGGTTGTGGCGGCGGTGGCGGCGGTAGCACCGTC CGCACATACCGCGGGAACGCGGGCATCCGAATTTGGGGCAGGGTGTTCAAGGCGGCTGGCAACTCACCATGAATCT Clone Rv4 :::::::::::::Rv4SP6.seq::::::::::::: CCGGCTCGTATGTTGTGTGGAATTGTGACCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCA (SEQ ID NO. 591) AGCTTGGCCGCAGGGCCGAGTCGATTGGTCGCGGTCGCCTCGACAGTTAGCTTATGCAATGCTAACTTCGGGGCAAAGTTCAGGCGGATCGGCCGATGGCGGGCGT AGGTGAAGGAGACAGCGGAGGCGTGGAGCGTGATGACATTGGCATGGTGGCCGCTTCCCCCGTCGCGTCTCGGGTAAATGGCAAGGTAGACGCTGACGTCGTCGGT CGATTTGCCACCTGCTGCCGTGCCCTGGGCATCGCGGTTTACCAGCGTAAACGTCCGCCGGACCTGGCTGCCGCCCGGTCTGGTTTCGCCGCGCTGACCCGCGTCG CCCATGACAGTGCGACCCTGNACCGGGCTGGCC :::::::::::::Rv4T7.seq::::::::::::: GTGTGCTGTCAATTCAGAGCTGAGCCTGATGCACTCAACTTACTGAGCATGCTAACGCTGGTCGTGCGGGTCTTGTTCCCGCGTGTCGGCAGGGCACACGCTCGGG (SEQ ID NO. 592) GCGTAGCTGGGAGAGGCCCCGGTCAAGCCCGGAGAGCAGTGCTCAGTCCGCCAGCTTGACCGACTTTCGATGAGAACGCGCTTCTCGCCGTATTGAACTGGCGTGC TGACGGTCGCTGAGCAGCGCTCGCCGAGTGCGGCCGCTGATTCTTTCATCGAGCCAGGAGGCGCATTCGTGTTCGGCCGCCTGCGGGTCGGCCCCATCGTCGACGC GATCCGTCACCCACTCCTCGATCAGGTCTGCCTCATCGAACGGGCCAACGGTGCTGTCGGAGTAAGTGTGCGTGGGCACGCGAGCCGGGTGCTGTGGTACACCCAC CGTTGCATGAACAA Clone Rv50 :::::::::::::Rv50SP6.seq::::::::::::: ATACTCAAGCTTCACCAGGCGCCGGCGGGCCGCGGCGCCAAGCCAGGCAGCCGCGCTCGGCGCGTCGGGGCCTTCCGCCGGCTCGGCCGACAGTTCGATCTCTGGA (SEQ ID NO. 593) TCGGCGGGGCTCTCCGGGCCGGCCTCGGCGACCTCAGCGGGCCGCGCCTTCCGGCCGAACCATTCCCTAGCCATAGATAACCGCACCTCAATGCACGGTTTGGCGG CAACCCGG :::::::::::::Rv50T7.seq::::::::::::: AGCTTCCGTCACGACCCGCCCTCGCCGGTGCCGGCGCCATCGGTCATCGGATCTCATGACGACGTCACGTAGGCCCGCTAGCCGCGAGCGGGCGCGGTCAACTGGC (SEQ ID NO. 594) GAGGCGGCGGCGACGTGACTGAGCTGGCCGAGCTGGACCGGTTCACCGCGGAACTACCGTTCTCGCTCGACGACTTTCAGCAGCGGGCTTGCAGCGCGCTGGAACG CGGCCACGGTGTTGCTGGTGTGCGCGCCGACCGGCGCTGGCAAGACGGTGGTCG Clone Rv51 :::::::::::::Rv51SP6.seq::::::::::::: ATACTCAAGCTTGCCGGGACCGCGGAACAGAACCGGCGGTTCCTACCGCGGTGTGCGGCCGGCGCGATATCGGCCTCCCGACTAACCGAACCCGATGTGGGCTCC (SEQ ID NO. 595) :::::::::::::Rv51T7.seq::::::::::::: ACGTTGGCTCTGCCGGAACGTATTTCCAGCGGCACGCATTCGGCGTGGGTGCCGGGCGCCGAGTTGCGTCGCTGGGATCACGCAGCAGTCGCCGGCGGCTGCCGTC (SEQ ID NO. 596) GGGCTATGAATTGCACCGAGCCGGAAAATCCNCAC Clone Rv52 :::::::::::::Rv52SP6.seq::::::::::::: ATACTCAAGCTTGTCGTATTCCGTGGCACTGTCAGACATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATCGTCGCCGGCGGTCATGGCGTCACCCTACCCAA (SEQ ID NO. 597) GCCGAACGCGAAACGAGAACGTGTTCCATTATTAGGGTGTGAGCACCAATACCAGATTGCTCACCAGGAACTCACGCAGCACCGGGACGGATGTCAGCCACCACCC CCATCTGGGGTGGTAGCGGGGA :::::::::::::Rv52T7.seq::::::::::::: CGTTGGTAGCCCGATATGCATAGTGTATCTTACTGAACATGATTTCCATTATGGAGCCCGGGGTGCCGGCAGCGCGAACGGTGCGCCGTCAGACGCGGGCGGCACT (SEQ ID NO. 598) GACCAGGGTGTTGCGGGCGAACATCGGCCCGGCTTCGGATTCCGGTCCGGGTACCGGGCGACCCACCGCTTCGAGGTC Clone Rv53 :::::::::::::Rv53SP6.seq::::::::::::: ATACTCAAGCTTGGCCAACTCCTCATCGGACTTGAAGGTGCCGTCCTCGTTGGCGGCCCTGCTCCACGGCACGTTGATGGCACCAGGAATGTGTCCGGGCCGCTGG (SEQ ID NO. 599) CTTTGTTCCTGCGGCAGGTGCGCGGGGGCCATGATCTTGCCGGAAAACTCGTCGGGAGAGCGCACGTCGATGAGGTTCTTGACGTTGATGGCCGCCAGGACCTCGT CGCGGAATGCCCGAATCGTGTTATCCGGCGGGGAGGCGGTGTATGAGGTCACCGGCCGGCTGACCGGGTCGCTGGACAGCGGGCGTCCGTCCAGCTCCCACTTCTT GCGGGCGCCGTCCAACNACTTGACTTCTCCTGG :::::::::::::Rv53T7.seq::::::::::::: ATATCTTAAGCGTCGGGTCCCGAGGCTCGGTCGGCAGCTCCAGCAAAACCCGCTCCACCCCTAGATGCCGGTATCCCTCAAGGTCTTTAGCCGCCGCTTCACCCCA (SEQ ID NO. 600) CTGGCACACGGTCACCGGCACGTCGCCCCCGGCCATGGCGCGCAACCGCTGAAGCGGACCCGACAGCCGCTGCGGTGATGGACTGATCGCGATCCACCCGGCATTG AGCCGGGCTATCCGCGGGAAGTTCGCCGGTCCCCCGCCCACATACAGCGGAGGATAGGGCTTTGTCACCGGCTTCGGCCAGCAGTAGATCGGATCGAAGTCCACAT ATGTCCCATGGAATTCCGCCTGCTCCTGCGTCCAGATCTCGATTATCGCGCGCAACCGCTCATCGATCACACGTCCGCGCACCGCAGGGTCCACACCATGGTTGGC GACTTCTTCGCGCA Clone Rv54 :::::::::::::Rv54SP6.seq::::::::::::: ATACTCAAGCTTGTCGCGGTAAACCCGCAGCAGGGCGGTGGGTGCGGTGTCAAAAACAACCACACTTCTTTGCGGTTCGGTGATCTCGACACCGGCCGCGAGCCGA (SEQ ID NO. 601) CCACCATGCGCGCGTAAATCGGCGATCAGCGCGTCGGCTATCGCCTGGGTGCCGCCCACCGGAATCGGCCAGCCGACCGAATGGGCCAGCGTTGCCAGCATCAGTC CGGCGCCGGCCGACACCAGTGACGGCAACGGTGAAATCGCGTGGGCGGCAACGCCGGTGAACAACGCGCGGGCATCCTCGCCCGCCAGCGACCGCCAGGCAGGGGT GCCCTGGGCCAGCATCCGCAGCCCGAGACGCAGGACCGAGCCCAGTGCAGTAGGCAAAGACCGCTTGTCGGAGACATGAACTCCACGACCGT :::::::::::::Rv54T7.seq::::::::::::: AGCTTATTGAACCGCGGGTCGCAGGCAAAGTGGACCTCATAACGACTCGGGTCCAGCGACCGCGCCAACACGAACGGCCGGACGACGTGGGCCAGGGTCGCGGCCT (SEQ ID NO. 602) CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGGCGCCGTGCTCGTCCCAGCGTCCGGTCCCGGGTCGCCGGCGACGCTTGTTTC CTCCATACTCGCCCCCTAATCTCGAGGCAGCCCGTACCCGCAGGCAACCTCCCAAAAATGCAATCCCCCAAAATGCAATGCGTCGAGCTATTTCTCACACCGACCG CTAGTTGCGGATCAGAAATCCGTTGGGCGCGGAAGTCCAGCCGAATTTGTTCTCCCGCTCCGCATCATGCTTGTAATCGTTTGGAAATTCATCCTCATATGCCTCG ATCGCTTCATAGGGTCCAGGCCAAACCGGGCA Clone Rv55 :::::::::::::Rv55SP6.seq::::::::::::: CTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATAC (SEQ ID NO. 603) TCAAGCTTGGCCACCTCGCGGTGTGTGGTGGAACCCATCTGAGCAGTGTGCCAAACCGGGGCAGACAGCTCCCAATTGACGTGAGCCCGCTCACTTGCTGGGTAAG CGTCG :::::::::::::Rv55T7.seq::::::::::::: TAGCGCCCCCTCCCGGGCGGAGCTCCACGGCGTGGATCAAGGTACCGGCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGATGTCGGCGTTAGCGCCGGA (SEQ ID NO. 604) TTCCACCACATCCCCTTGCGAAAGTCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTAC TCGATGTGCGCGACCTTGGCGTTGACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTGGTAATCC GGCCATGCGCGTTGCGTCCACCGCGACCGTGCAGCGGGCGCACCAGCGACTTCTCCGGGGTTGACCGGGTGATCTCGGCGAAATCAGATACGCTGGCGCCGCGACG ACCAAGCGTCGTGGGCTTGTTCTTGCGAATTGCATGTCTAATCAGGTCTTTCTC Clone Rv56 :::::::::::::Rv56SP6.seq::::::::::::: TGAAACTAATATAATACTCAAGCTTGCCAAAGAAGACCTCGTCGACCAAGCAGGACGCGACCGTCGAGGTGGCGATCCGGCTTGGCGTCGACCCGCGTAAGGCAAAC (SEQ ID NO. 605) CAGATGGTTCGCGGCACGGTCAACCTGCCACACGGCACTGGTAAGACTGCCCGCGTCGCGGTATTCGCGGTTGGTGAAAAGGCCGATGCTGCCGTTGCCGCGGGGGG CGGATGTTGTCGGGAGTGACGATCTGATCGAAAGGATTCAGGGCGGCTGGCTGGAATTCGATGCCGCGATCGCGACACCGGATCAGATGGCCAAAGTCGGTCGCAT CGCTCGGGTGCTGGGTCCGCGCGGCCTGATGCCCAACCCGAAAACCGGCACCGTCACCGCCGACGTCGCCAAGGCCGTCGCGGACATCAAGGGCGGCAAGATCAAC TTCCGGGTTGACAAGCAGGCCAACCTGCACTTCTC :::::::::::::Rv56T7.seq::::::::::::: GCTGAGCTCCACGGCGTGGATCAAGGTACCGGCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGATGTCGGCGTTAGCGCCGGATTCCACCACATCCCCT (SEQ ID NO. 606) TGCGAAAGTCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCT TGGCGTTGACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTGGTAATCCGGCCATGCGCGTTGCG TCCACCGCGACCGTGCAGCGGGCGCACCAGCGACTTCTCCGGGGTTGACCGGGTGATCTCGGCGAAATCAGATACGCTGGCGCCGCGACGACCAGGCGTCGTGGGC TTGTACTTGCGAATTGCCATGTCTAATCAGGTCTTTCTCT Clone Rv57 :::::::::::::Rv57SP6.seq::::::::::::: ATACTCAAGCTTGTTGGTGACCTCGCCGGCGAACAGTTCTCGCACGATTTCCGGATTAGCGGGACTGGTCACCAGTTGGGTATGCGGGAAGGCGCTGACGTTCGCC (SEQ ID NO. 607) GCGATTAGCTGTTTGATGGACGCGGCGGTGATGTCCTGATCACGGAACTGGCTGTAATAGCCCAGGGTCGCCACGCTTCCATCCGGGCCCGGACCCGGC :::::::::::::Rv57T7.seq::::::::::::: GATGATCGCCGGTGCCACCCCGATCCGTGCCTCGGTCAGCGCGAACGTGCTTTCCGGTCCGGCGACCACCATGTCGCACGCACCGACCAGGCCGAACCCGCCGGCC (SEQ ID NO. 608) CGCACATGCCCGTTGATGGCGCCGACCACCGGCAGCGGCGACTCGACGATGGCGCGCAACAGCGCCGTCATTTCCCGCGCCCGCGCCACCGCCATCCGGTACGGAT CACCACCACCTCCGCCGGCCTCGCTGAGGTCC Clone Rv58 :::::::::::::Rv58SP6.seq::::::::::::: ATACTCAAGCTTGCCGCAATCGAAACCAACCTGTTTGTGCCGCAAGAAATTACGCCGTGGCCCGGCGCCGATCAAGAAACGCCCCGGCGCGCGGCGGTGTCGTCGT (SEQ ID NO. 609) ATGGCATGACGGGCACCAATGTGCACGCCATTGTCGAGCAGGCACCGGTGCCAGCCCCCGAATCCGGTGCACCAGGCGACACCCCGGCCACACCCGGTATCGACGG CGCGCTGCTGTTCGCGCTGTCGGCCAGCTCGCAGGACGCGCTGCGGCAAACCGCCGCGCGGCTGGCCGATTGGGTCT :::::::::::::Rv58T7.seq::::::::::::: TTGGCGGGTTGGCCACANCANCCCGCCGGTGACGGCGACGATGCTGGGCTGGTTGCGGCCCTGCGCCACCGCGGCTTGCATGCTGGTTGGCTGTCTTGGGACGATC (SEQ ID NO. 610) CCGAAATAGTCCACGCGGATCTGGTGATTTTGCGGGCTACCCGCGATTACCCCGCGCGGCTCGACGAGTTTTTGGCCTGGACTACCCGCGTGGCCAATCTGCTGAA CTCGCGGCCGGTGGTGGCCTGGAATGTCCANCGCCGTTCACCTACGTGACCTTGATGGGATCCGGGGGNT Clone Rv59 :::::::::::::Rv59SP6.seq::::::::::::: NCGTGGACACCGGTGTCGANCGCCACCAGCCGCATGTCTGCANGTCNATTCCGTCCTCGGCAACATCTTGAATGCCGAGCAGCGCCTGGGCGTGATCGGCAACCGG (SEQ ID NO. 611) GGATGACCGCTCGCCGATCCGCTCGACAATCCCGGCGGCACGTGACATGCCGGCGGACGGCTCGACGAGCTGGAACTTCAGCGACGACGATCCGGAATTGATCACC AGCACGGTGCTACTCATGGACCCCTGCGCCTGAATCCCGTGATGGCCACGGTGTTGACTATTCGTCGACAGTGCACCCGAGATAGTCTTCACGGCTGCGT :::::::::::::Rv59T7.seq::::::::::::: CATGTATTGCCGTGCTCACGGCGCCACGCTCGATGGTTTCTCGAAGTCTCCGGGCTGGTGTACAGCTTCTCGTTGATCTCGTTCGCCACGCCGTCCTCTTCCCGCC (SEQ ID NO. 612) GACGACCCGATCTCGATCTCCANAATGATCTTGGCGGCCGCCGCCGCCTTGAGCAGCTCCTGGGCGATGGCCAGGTTCTCATCGATGGGCACTGCCGACCGTCCCA CATGTGCGACGGAACAAAGATGTCACCTTGCTCACGCGTGCGCNAGATCNCANAAGGGCCGGACATACTGTCNACTTGTCCTTGGGCAGTGGTCCGTGTCAGCCCA CGTGACGGGTACTTGGCGCGATAACGTGGTG Clone Rv5 :::::::::::::Rv5SP6.seq::::::::::::: GCCACCACGACCCGGCCGTAACTCTGCTCACGGAAATGCGGCCAGGCCGCGCGTAGCACGTGGTATCCGCCATAAAGGTGCACCTTAAGCACGGCGTCCCAATTCT (SEQ ID NO. 613) CGAACGACATCTTGTGGAAGGTGCCGTCGCGCAAGATCCCGGCGTTGCTCACCACACCGTGCACGGCGCCGAATTCGTCAAGCGCGGTCTTGATGATGTTCGCTGC GCCGTCCTCGGTGGCGACGCTGTCCTTAGTTGGCGACCGCCCGGCCCCCCTTGTCGCGAATCTCGGCGACGACCTCATCGGCCATCGCCGAACGGCGCCCGTGCCC GTCGCGGGCGCCACCGAGGTCGTTGACCACGA :::::::::::::Rv5T7.seq::::::::::::: CAGGCATGCAACCTTTGTCCACACGGCGTCTACTCCGTGCAAGGTCCGACCGCTTCCACGTCCCGCCGTGACGGTGCTCCATCTCCCTCAGCAACGCGTGAAGTGG (SEQ ID NO. 614) TCCGATCCCGCGGCTTCAGG Clone Rv60 :::::::::::::Rv60SP6.seq::::::::::::: GTTGAGACGCAACCAGCGCACAACGACGATTTGGCGTAGCGGCGGACGTCTGCTCGATTCGATCACGTCGCGCTCGCATCGAGCATGGCCCGCGACGCTACACGAT (SEQ ID NO. 615) CGCCGTCGTCGATGACACGACCGAGCCGTACGCCGGCCGTAAGCCGCGCCAGGATTCGGCGAAAAACGTCTACGTGGCGGGTGTACTGGGTGTCGAATGATTCGTG GGGTGCGTATGCGTCCTGCAATCGTCGACATAGATCCGTCGCCGCATCGCGTCGACAACTCCGGGTGAGTGGAATACACTTGCCGATCACGCGACGTGCGCGGATC GATGCCGACCGAAATACGACCACATGGCTCTTGTTGCNCAGTGTTGGCGGCATCAAATACCCTCAGTGCCGTCCGAC :::::::::::::Rv60T7.seq::::::::::::: TTNCCGCCTTNACGCCTACTCCNAGACGATGCTCGACGCGTGTGAGCACACGGCGCTGCTGTAGACGGCACGGCGCAGCTGGATCGCGCTTGGTGCACCCAAGCCT (SEQ ID NO. 616) CTACGCGCGTCGCTGCGTCGTCATCGGGTACCGAACATATTCCGGTCGTTGCGCAGAGTGTGCATGTGCGGCTCTTGTGAACGAACATAGCAAAGCGTATATGTCT GTGGCGGCTCTGCAGATATCGCGATAATACGTATATACATAAGGTGGCGCGCGATCTATCGGTATATCCGTTATGGCGGACGTGCGTGAGCGTGAGTCGCGGCGCA TCGCGCACTTCGCGATCGCGTGACTGGTCCTCGCGACTGCGCGCATGCGTAGC Clone Rv61 :::::::::::::Rv61SP6.seq::::::::::::: GGTGATGACGCACTTGCTTCGAATGAGTCATTGACTACTCCCGTGGTTGTCCTGCGATGGTGGAGTGCCGCGCAGCCTTGCCCGANGTCGCGATCGCGTCGCGGGC (SEQ ID NO. 617) TTCGGGGAGCAGACTGACCTGCAGATGGAAGTCGTGCCACATGCCCGCGAACGGCGAGCTCGATGCTTGTTTTCGAAGNGCGCANGCGGTTTCGATCTTGTCCGCG TCAACGCAGATCGGATCTCGCCGCGGTCTGCATGACGATGGGCGCAGGCCCGCTCATGTCCCGTAGACGGGGAGATACGGGCAGCCGCGGATCGAGACCTACGTAG CGCGGCGCCCATCGTGCCATCGACGAAGAATGACGGATCGCGCAGCGCCGTCGCGTCGCTTCGATGTCACGCGAGATCGCCACGGCAGATCAGCGATGCGCGGGC :::::::::::::Rv61T7.seq::::::::::::: CGGTACGCCGGCAACAAACGCCTTGTGACGAGCGCGTCCGAGCGGTCATCGGCCTCCACCGTCATGCACAGCTCCTTCTCCAGGTCTACGCCGACGTCGCGGTCCA (SEQ ID NO. 618) CATTGGTGAGCTTGGCGAATGCCTCGGCAACCTCGTCGAAATGCGCCTCCGCGTCCGCATCGAAGGTCGCCATGTCAAAGATCAACTCGACGTAGTAGCTAGTTAC CGCATCAGGTCAGTGTTTGCTGGCCTCGGAGTCCGGCCGAACAATGGCCATTTCCCGCGACTCTAGAATCCAGTCATCGTCTCGGTGACGACGCCTTGCCGATCAC ATAGCTCGACCGGATCGGAGAGAATCTGGTTCTCGT Clone Rv62 :::::::::::::Rv62SP6.seq::::::::::::: ATACTCAAGCTTAAGCGCAGCAGTACCGGCGGTGCCTGGGCATCCCAGCAAAACGGGGAGCTCAACGAACGATTCCTGAACGAAGGGTCGTCCACCAACCTCCAAA (SEQ ID NO. 619) CCGAACGGTTGCCAGCCCCGGC :::::::::::::Rv62T7.seq::::::::::::: GCAAGTCCGCTCAATGTGGTTGTGATCACANGACTACGTCGCCTCAATCAGCTCAAACGTCACCCCGTGGCGTGCTGCGCAGCATGAAGGTCGGCGCCCGCACGAT (SEQ ID NO. 620) GTGGGCGAAGCAACAGGTAATAACTGGTCGGCATGGGTCAACCCTCATTGGGCCGTTGCGGATCGGGTGCACGCCCGGAGTGCCGGTCGAACTCAACACCGCCTTC ACCGATCTTTTCGTCGAAAATGGCGGTCGTGTCGGGGTATACGTCCGCGATCCCACGAGGCGGAATCCGCTGAGCCGCACTGA Clone Rv63 :::::::::::::Rv63SP6.seq::::::::::::: ATACTCAAGCTTCGCGCCCTCAAGCGGCTGAAGGTGGTTCCGGCGTNCCAACNGTCGGGCAACTCGCCGATGGGCATGGTGCTCGACNCCGTCCCGGTGATCCCGC (SEQ ID NO. 621) CGGAGCTGCGCCCGATGGTGCAGCTCGACGGCGGCCGGTTCGCCNCGTCCGACTTGAACGACCTGTACCGCAGGGTGATCAACCGCNACNNANNGNTGAAAAGGCT GATCGATCTGGGTGCGCCGGAAATCATCGTCAACAACNAGAANCGGATGCTGCNGGAATCCGTGGACGCGCTGTTCGACAATGGCCGCCGCGGCCGGCCCGTCACC GGGCCGGGCAACCGTCCGCTCAAGTCGCTTTCCGATCTGCTCA :::::::::::::Rv63T7.seq::::::::::::: TGCGCATGGCAGTTGTTGCCGGCTTGAGTCGCGTTAGCGCGGATTCCACCACATCCCTTGCGAAGTCGTGGGTGCAATGATGTAGCGCTTCTCCCATCGAGATAGT (SEQ ID NO. 622) GGAGCAACGCAATCCGTGCGTACGTTGGGTCGTACTCGAGTGCGCANCTTGGCGTTGACACCATCTTTGTCATTGCGGCGAAGTCGATCATCCGGTAAGCGCGCTT ATCGACGCCGCCTCTGTGCCGGGTGGTAATCCGGCCATGCGCTTGCGTCCACCGCGACGTGCAGCGGGCGCACACCGACTTCTCCGGGTGACGGGTGATCTCGGCG AATCAGAACCTGGCGCGCGACACAGCGTCGTGGCTGTACTTGC Clone Rv64 :::::::::::::Rv64SP6.seq::::::::::::: TGGGTGATCAGATACTGGCTAGTTGGTCGGGTGGGGTGATCGAAGATCGCGGTGGCCGGCAGCGTTACTGCGGTGACGCTGTTAAGCGGTTACGTACTCCACGGCA (SEQ ID NO. 623) CTCAANGAATTANATCCCGAATCGGCAAACCCTGGCCAGCGTCGAGTCCGCAGCGCCGTCGCGCCCCCCACCGCTGCGGCATGCTCACATACCACCTCGATCGCTG CGGGAGTTGCTCGTCGGCCGACCGACCGGCCAGCCGGGCGGCAAACCGGAGGACCCAAGATTCAGCACCACCATCGCTAGCCCGATCTGGCCGCGCGTGG :::::::::::::Rv64T7.seq::::::::::::: TCGTAGCGGTTGCGACCANTCCGCGGACAGCTCCGCCACGCGACGGGTCGGGATCACCGCGGTCAAACCACCGAGCGGCGAGGATCTCTGGCCGTCGACGTGACCG (SEQ ID NO. 624) CGCACGGCCGCGGTGATGGCCAGTCCCGACCGCCGTTCCACTTGGCGTACGCGCTGGATGTGTTGTGCCGCAACGGAATCCCACCTCAATTATGACCTCGTTGTGG GCGAGCGCGGTATCGTACGCCCGACCAGGAATCGTCGATGCTATCTCACGTCACCGAAGGCCTCTCCCAGCACACCGCATCCAGAACGTGCACACNGTCGACATGT CTCGGCGGATCCGCCTGCAGAACGAACGCCANGTGCGCTGTGCGACACGGGTCGCGATCACCGCTCGCACGCGGAGATCGGCACACGCGCAGCGCATCGATCATAA TCTCTCGATGCGGTCTCCACCACCGAACAG Clone Rv65 :::::::::::::Rv65SP6.seq::::::::::::: ATACTCAAGCTTCGCTGAGGTGGTGGGGCACGATCACGTCACCGCACCGCTGTCGGTGGCGCTGGATGCCGGCCGGATCAACCACGCGTACCTGTTCTCTGGGCCG (SEQ ID NO. 625) CGTGGCTGCGGAAAGACGTCGTCAGCGCGTATCCTGGCNCGGTCGTTGAACTGTGCGCAGGGCCCTACCGCCAACCCGTGCGGGGTCTGCGAATCCTGCGTTTCGT TGGCGCCCAACGCCCCCGGCAGCATCGACGTGGTAGAGCTGGATGCCGCCAGCCACGGCGGCGTGGACGACACCCGCGAGCTGCGGGACCGCGCGTTCTATGCGCC GGTCCACTCACGGTACCGGGTATTTATCGTCGACGAGGCGCACATGGT :::::::::::::Rv65T7.seq::::::::::::: GCACTCACGCTGGTACAAGACCTTCACAAAATCTGAAATCCTGACCCGATACTTGAACCTGGTCTCGTTCGGCAATAACTCGTTCGGCGTGCAGGACGCGGCGCAA (SEQ ID NO. 626) ACGTACTTCGGCATCAACGCGTCCGACCTGAATTGGCAGCAAGCGGCGCTGCTGGCCGGCATGGTGCAATCGACCAGCACGCTCAACCCGTACACCAACCCCGACG GCGCGCTGGCCCGGCGGAACGTGGTCCTCGACACCATGATCGAGAACCTTCCCGGGGAGGCGGAGGCGTTGCGTGCCGCCAAGGCCGATCCGCTGGGGGTACTGCC GCAGCCCAATGAGTTGCCGCGCGGCTGCATCGCGGCCGGCGACCG Clone Rv66 :::::::::::::Rv66SP6.seq::::::::::::: ATACTCAAGCTTGTATAAAAAGATCGGTGAGCGCATCGATTCGCTCCGCCGGGTTTGCCGCTGCGGCGGCGGAGCTGCCGTGACCGTCTATTTGGGTGATCAGATA (SEQ ID NO. 627) CTGGGCTAGTTCGGTCGGGGTGGGGTGATCGAAGATCGCGGTGGCCGGCAGCGTTACTGCGGTGACGGCTGTTAAGCGGTTACGTACCTCCACGGCACTCAAGGAA TTAAATCCCGAATCGGCAAACGCCTGGCCAGCGTCGAATCCGGCAGCGCCGTCGCGCCCCAGCACCGCTGCGGCATGCTCACATACCACCTCCATCGCTGCGGCGA ATTGCTCGTCGGCCGACCGACCGGCCAGCCGGGCGGCAAACCCGGAAGA :::::::::::::Rv66T7.seq::::::::::::: CCTCATCATATGCCGATAGAGCTCTACATATTCAGGAGATCACCATGGCTCGTGCGGTCGGGATCGACTCGGGACCACCAACTCCGTCGTCTCGGTTCTGGAANGT (SEQ ID NO. 628) GGCGACCNGGTCGTCGTCGCCAACTCCGGAGGGCTCCAGGACCACCCGTCAATTGTCGCGTTCGCCCGCAACGGTGAGGTGCTGGTCNGCCAGCCCGCCAAGAACA GGCAGTGACCAACGTCGATCGCACCGTGCGCTCGGTCAAGCGACCATGGGCAGCGACTGGTCCATAGAGATTGACGCAAGAAATACACGCCCGGAGATCTCGCCGC ATTCTGATGAACTGAACGCGACCCGAGGCTACTCGGTGANGACATNACGACGCGTTATCACACCCCGCCTNCTTCAATGACCCCACGTCNGGCACCAAGGACCCGG CAATCGCGGCTCACTTGNGCGATNGTCNACAACCAACGCGNCGCCTGGCTACGGGCTCAACAAGGCANAAGACACAATCCGCTCTCGATTGGTG Clone Rv67 :::::::::::::Rv67SP6.seq::::::::::::: ATACTCAAGCTTATCGAGGCGGCGCATACCGAAGCGTGGGAAATCCAGACCGAATACCGCGACGTGCTGGACACTTTGGCCGGCGAGCTGCTGGAAAAGGAGACCC (SEQ ID NO. 629) TGCACCGACCCGAGCTGGAAAGCATCTTCGCTGACGTCGAAAAGCGGCCGCGGCTCACCATGTTCGACAACTTCGGTGGCCGGATCCCGTCGGACAAACCGCCCAT CAAGACACCCGGCGAGCTCGCGATCGAACGCGGCGAACCTTGGCCCCAGCCGGTCCCCGAGCCGGCGTTCAAGGCGGCGATTGCGCATGCTACCCAAGCCGCTGAG GCCGCCCGGTCCGACCCGGCCAAACCGGGCACGGCGCCAACGGTTCGCCCGCCGGCACCACCGGTCCGGTGACCGCAGTACGGTCCCCCCAGCCTGACTACCGTGC CCCGGCGGGCT :::::::::::::Rv67T7.seq::::::::::::: TGGCCGGGCTGGTAGCCCGCGTATGGCAAGGTTCCGCTCAATGTGGTTGTGATGCAGCAGGACTACGTTCGCCTCAATCAGCTCAAACGTCACCCCCGTGGCGTGC (SEQ ID NO. 630) TGCGCAGCATGAAGGTCGGCGCCCGCACGATGTGGGCGAAGGCAACAGGTAAGAACCTGGTCGGCATGGGTCGAGCCCTCATTGGGCCGTTGCGGATCGGGTTGCA GCGCGCCGGAGTGCCGGTCGAACTCAACACCGCCTTCACCGATCTTTTCGTCGAAAATGGCGTCGTGTCCGGGGTATACGTCCGCGATTCCCACGAGGCGGAATCC GCTGAGCCGCAGCTGATCCGGGCTCGCCGCGGCGTGATCCTGGCCTGTGGTGGTTTCGAGCATAACGAGCAGATGCGAAT Clone Rv68 :::::::::::::Rv68SP6.seq::::::::::::: GTCCAGTCAAGCATCGGTCCTCTCCGACTACGCCAAGANTGGCGACGTGTCAGTGCANACAGCGGANATGGTGGCGCCTATGCGTCGACGCTCACAAACNGCGGTG (SEQ ID NO. 631) ANCGCGTTCTGGTCGTGCACCATCGAGCCGTGCCAGCCCGGCCGCGTGCCGTCAGCCGCATCCACTGGATGCCTTCTCGGNGTTTCAATCANGTACANGCGACGTT CGCCACCATCGTGCCGGGGCACGGTTAGCGAGAAACCGCCGACTTCACCGATTGCCTCGGTGATGCCGTCGAACAGATCGGGCCTATTGTCGACAGCCAGTGTGAT NCGTATTTGCCGCCGTGCTCCTCGTCGCAACGATGCGAACACAGATCCGTGGNGGACGATAGCGGCTGACAANGTGGGGGCAACACAATCACATGCCACATTTCTT CATTTCACGCCCACAACCCAGACTTCGTCTCGATGNGCCG :::::::::::::Rv68T7.seq::::::::::::: CACGCGGTCTGGCCCGATCCGAAGATCCCTTTGCCGGCGTGGCGGCTCTGCTCGGCGGTGTTGTACACTTCTCGAACACCTCGGCACCGACACCACCACCGTNGCT (SEQ ID NO. 632) TGAACACCGCCAACATCGGCAGCAGATCTTGATGGTCCTGGTGAATCCCACGGTGACTTTGGAGTGGAAGGCGCCATACTGATCGCCGCGCCAGCACATGAGCTAG CGGCAGGAAAACCAGCAGCCGCTCACCTTGCGCAGCAGCGTCNGGTGATATGCCTGGCGCCCTTAATCTCGTGAACCAGTTGGATTGGGTCAACTGGCAGCCTTGG GTCTCCGGTGGTGCCGANGTGTANATAAGCTCCCGGGTCCGTCAACGTANTGCGCAGGCGGCGGTTACTCGGCGGGTCAACGAGCCCCGCTCGTGAGCNATCAGCC TTTGGACCGAACGGGATTCATACTCCGCAGGCGGCCCTCCGAAATCGGCACATGTCCTTTGATCGTTCGCAACAN Clone Rv69 :::::::::::::Rv69T7D3.seq::::::::::::: GGCCATGTCACATCGGTGGTACAGGTAAACCGCGCCGTGTGCGCGGTCTCGGAGATCAGAACGTGGTCGCAGTTGAACCGCGGGCTTTCAGCCAGTCGCGATAATC (SEQ ID NO. 633) GGCGGAAGTCGGCGCCTGCCGCCCCAACTAGCGCGACTCGCCACCTAGCACACCGATGGCGAAGGCCATGTNTCCGGCCACGCCGCCGCGGTGCATCACCAAGTCA TCGACTAGGAAGCTAAGCGACANCTTGTGCAGGTGTTCGGGCAGTAGCTGCTCGGAAAATCGGCTGGAAACCGCATCAAATGGTCGGTCCAATCGAACCGGTTACC CGATCGTCACAAAAATCTCGTCCT Clone Rv6 :::::::::::::Rv6SP6.seq::::::::::::: GGGTCTACAACCACCGGGTCTGACTTCTGGGCTTCCACCGCTCGCGCCGTCGCGACAAACAGCGCGGTCGAACCGACACTCGTTGTGATGTCCCAGCTATCACCTC (SEQ ID NO. 634) CGGTAGGCACCCAATCGACCCTACCCGGCTATCTCACCCCCGATCTCCAGGCTCCGCCGATCCATGCGCATCCCGGTCCGGATCCC :::::::::::::Rv6T7.seq::::::::::::: CAGGCATGCAAGCTTGTCGTATTCCGTGGCACTGTCAGACATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATCGTCGCCGGCGGTCATGGCGTCACCCTACC (SEQ ID NO. 635) CAAGCCGAACGCGAAACGAGAACGTGTTCCATTATTAGGGTGTGAGCACCAATACCAGATTGCTCACCAGGAACTCACGCAGCACCGGGACGGATGTCAGCCACCA CGCCCATCTGGGGTGGTAGCGGGGAAATACGGCTAACGCGGCTCCGGTGCCGGCAGCCCAGCGCAGACCCTCGGCGGCGGACACGGCTAACAACGACGACCCATAG TTGTTCTTTGCCGGATGGCCGTGTTTGCTGACATATCGGGCGCGGCGCCGGCGCCGCC Clone Rv70 :::::::::::::Rv70SP6D2.seq::::::::::::: NCTACGCTGCTGAATGTTGTGCGCCGGAGGANCTCAAGACCCACGCGGTTGTACGCGGACNTGCGACATGTTCAACCGCCGGA (SEQ ID NO. 636) :::::::::::::Rv70T7D3.seq::::::::::::: CTAACCAACAAGCCATGGTGGTTGGCGCCGTCGAGAGGTCGGCGGTCGCCACAACGGGAAGATCGCCTTGAGCGTCGCTCGACCGCCGCCTCGAGTTGGGTCATAA (SEQ ID NO. 637) CGAAGTACTGATGCCGATCATGTCGACGTGTCCGTCGCATCAGCGTGCAGCGGCGACCCCTCGACGAGCCTCGGTGCCGCCGCGGCCAGGGCACCAGCTGTTTTAG CGCATTGTGCTCCGCCGGTAATAAAGGANGTCGGTCGCCTCCGCTGCTGTGGTTGCGGAATAACATCTTCCCTTCCTGCAACAGGATGAGAATGGTTTTAATTGCT C Clone Rv71 :::::::::::::Rv71SP6.seq::::::::::::: CTAAGCTTTCGGGTCCGCCGCCACTAGTACCGCGTTGCCGGCCCCGCCGACCTAGAATCTTCCGCCCATTGCCGTTTCCTCCCGCCGCCGGGTT (SEQ ID NO. 638) :::::::::::::Rv71T7.seq::::::::::::: TCTGGTGCCGGGTGTGCCGACGGGTCCGTCCGCCTCTGCTTCAGTGATTCTGTGATGCGACCGGCAACGTCCTCGTTGTTCGGTGTCTATGTGGTCCGTCTCTCCT (SEQ ID NO. 639) TGTTCCGCATACGATT Clone Rv72 :::::::::::::Rv72SP6D2.seq::::::::::::: GCGATCGNTNACCACAAGGGCGCAACCGTTCGCGCGTCGACTGAACGTGCTGCCGCCTGGAGAACTGGCGCTGCTGCCACCTGGTCGGCGCATCGGCACTTCGAGG (SEQ ID NO. 640) ACTGGATTTCGACGCGTGGCCCGACCTGANGTNGGCGGTGGACNNGTGTGCACCCGGTTGATTCCTCGGCCTTGCCGGGATGCCACCTGCGCCTGGTGGTCGAT :::::::::::::Rv72T7D3.seq::::::::::::: CGTGACCGGACGGGGTGCCGCGCGAACCGGTCTTGGCCAATTGCCGGGGACTGGGGCTGGAGTATAAAGCGGGCCTGTTGCCGGAAGATAAAGTCAAAGCGGTGAC (SEQ ID NO. 641) CGAGCTGAATCAACATGCGCCGCTGGCGATGGTCGGTGACGGTATTAACGACCGCCAGCGATGAAAGCTGCCGCCATCGGGATTGCAATGGGTAGCGGCACAGACT GGCGCTGGAAACCGCCGACGCACATTAACCATAACCACCTGCGCGGCTGGTGCAAATGATTGAACTGGCACGNCCACTCACGCCAATATCCGCCAGAACATCACTA TTGCGCTGGG Clone Rv73 :::::::::::::Rv73SP6.seq::::::::::::: ATACTCAAGCTTCTTACCCANAGCATGAACCCCGCCGTCCAATGCCGCCACCGTGGTGCTGTCGGCCGGCCGGGTGCGGGCACAATCGCCGAGTTCGGCGAACAGA (SEQ ID NO. 642) TCCTCGAAGGTCTTCACGGCCAGCGATTGTTGCACGTGTCAGCCAGCCAAGTCACGGTGGTTTGACGCCACACGTTCGCCACCGCCGCGCCGCGCATTAGGGCATC CTAATATAGGTTAGGCTACCCTANTTATTCCTGTGGTCNAAGGAGGCAGCCGAACGTGACCTTCCCGATGTGGTTCGCAGTTCCGCCGGAAGTGCCGTCAGCATGG CTGTCCACCGGCATGGGCCCCGGTCCGCTGCTGGCCGCGGCCAGGGCGTGGCACGCGCTGGCCGCGCAATACACCGAAATTGCAACGGAACTCGCAAGCGTGCTCG CTGCGGTGCAGGCAACTCGTGGCAGGGGCCCAGCGCCGACGGTTCGTCNTCCCCATCAACCGTTCCGTATTGGCTAACCACCTGCACGGTGGCACCGCACAACGCC GCCACAAACGCGCCCCGGTATAC :::::::::::::Rv73T7.seq::::::::::::: GGCCGAACTTAATCGGTTGTTGGCGGCTGCCGAGTTGGGTCACTCGGGGGGTGTGCACTGGCACATGGTGGGCCGGATTCAACGCAACAAAGCCGGGTCGCTGGCT (SEQ ID NO. 643) CGCTGGGCGCACACCGCTCACTCGGTGGACAGCTCGCGGTTGGTGACCGCGCTGGATCGGGCGGTTGTTGCGGCGCTGGCCGAACACCGTCGTGGCGAGCGGCTGC GGGTTTACGTCCAGGTCAGCCTCGACGGTGACGGATCCCGGGGCGGCGTCGACAGCACGACGCCCGGCGCCGTAGACCGGATTTGCGCGCAGGTGCAGGAGTCAGA GGGCCTCGAACTGGTCGGGTTGATGGGCATTCCGCCGCTGGATTGGGACCCGACGAAGCCTTTGACCGGCTGCAATCGGAGCACAACCGGGTGCGTGCGATGTTCC CGCACGCGATCGGTCTGTCGCGGGCATGTCCAACAACTTGAAATCCCGTCAACATGGTCGAC Clone Rv74 :::::::::::::Rv74SP6.seq::::::::::::: GCTTCCCCTGATACTCGACCAGCCCCACTCGGGCCAATACGTGAATGTCCTAGCATTTTTCACCCGTTCACGGGCTAGTCGAGTAGTAGACGATTGATTAGCCTGA (SEQ ID NO. 644) ACGTACCTCCGACGGCCAGCTGACGAACGGGTTTGACGGA :::::::::::::Rv74T7D3.seq::::::::::::: TCAGCTGTCTGTAGAAGGGCTGGCGATACTGTGCACTGTCTGATATCGCNNCGTNGTGGGACTATNCAGNCCATNANGATGCGGTTCNGNNNNTGCAGAGNATCCT (SEQ ID NO. 645) GGNACACATNCGGTTCACGTTAATCANCATCGCGANTTNCTNCGTNTTCGATTANTTCTGCTAACGNNTCTNNNAGTGCCTGCGGGTCGACTCTAGAG Clone Rv75 :::::::::::::Rv75SP6D2.seq::::::::::::: NCTCTGCCGGGCNAGAGCGCAGAGTCGGACGGCTTCGTCGATCGTGAAGCGACCNTGCGATGANCAGATATCGNTNACACTGCTCANAAACTTCGGATCATCGNTG (SEQ ID NO. 646) ATACACAGGCCAACGGGTAGCGGTTGTCCAACCGCTTCGTCAACGANATGGGATCGTGACGANCCTACGCTCGCAGGATATGTCGCNGACCNGNTCTAGANAN :::::::::::::Rv75T7D3.seq::::::::::::: CACTTCATGCTCGTGCGTTGGCNTCGATTTGCNCGAGNGGTTAGCTCCTCGAGTGNGTGACGTATCACTCCGGCNGACTANCCGTATCNGCGTCCCGCACCGGTCA (SEQ ID NO. 647) ACTGGTCTAGCCACACCGGGGAGAATNCNGCAGGCCNGCTATCGACCNATCACGGCTTGTCGNNAAGATAGNCAGCC Clone Rv76 :::::::::::::Rv76SP6.seq::::::::::::: ATACTCAAGCTTGCCAACCGCCACCCTGCATCCGGGGGGCGAGCACTGCTCCGCCGACCAGTACGAACCAACCTGCGGTGCCCAGGCCATTGACAATGTGCTGGTC (SEQ ID NO. 648) GGCGCCCGCGAGTTCTAGCACAGCAACGCCGCGGCCACCACAGGGGCG :::::::::::::Rv76T7.seq::::::::::::: CGGTCGGTGTGCTTGGCGGCGTCGGTATCAACACCGCCCACGAAATGGGGCACAAGAAGGATTCGCTGGAGCGGTGGCTGTCCAAGATCACCCTCGCCCAGACCTG (SEQ ID NO. 649) CTACGGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCCGGGTGTCCACACCGGAAGACCCGGCGTCGGCGCGGTTCGGCAAAACTTTGTGGGATTTCCCG CCCCCCC Clone Rv77 :::::::::::::Rv77SP6.seq::::::::::::: AATACTCAAGCTTCGCGGAGGTGGTGGGGCAGGAGCACGTCACCGCGCCGCTGTCGGTGGCGCTGGATGCCGGCCGGATCAACCACGCGTACCTGTTCTCTGGGCC (SEQ ID NO. 650) GCGTGGCTGCGGAAAGACGTCGTCAGCGCGTATCCTGGCGCGGTCGTTGAACTGTGCGCAGGGCCCTACCGCCAACCCGTGCGGGGTCTGCGAATCCTGCGTTTCG TTGGCGCCCAACGCCCCCGGCAGCATCGACGTGGTAGAGCTGGATGCCGCCAGCCACGGCGGCGTGGAGCAACCCCGCGAGCTGCGGGACCGCCC :::::::::::::Rv77T7.seq::::::::::::: GATGGCACTCACGCTGGACAAGACCTTCACAAAATCTGAAATCCTGACCCGATACTTGAACCTGGTCTCGTTCGGCAATAACTCGTTCGGCGTGCAGGACGCGGCG (SEQ ID NO. 651) CAAACGTACTTCGGCATCAACGCGTCCGACCTGAAATTGGCAGCAAACCGGCGCTGCTGGGCCGGGCATGGTGCAATCCGAACAAGCACGCTCAACCCGTACACCA ACCCCGAAGGGCCGCTGGCCCGGCGGAACCTTGTCCTCCA Clone Rv78 :::::::::::::Rv78SP6.seq::::::::::::: AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTCTGGGCGTCGTGGTGCCCGGCCTGCCGGTGCAGGAACTGGATTTTA (SEQ ID NO. 652) CTGCCATCTCTCGCGACCCTGAGGTGGTCCAGGCTTACAACACCGACCCACTCGTGCACCACGGACGGGTTCCGGCCGGGATTGGCCGCGCGCTGCTGCANGTGGG CGAGACCATGCCGCGGCGANCACCGGCATTGACCGCGCCGCTGCTAGTGCTGCACGGCACCGATGACCGGCTGATCCCCATCGAAGGCAGCCGTCGCCTGGTCNAA TGTNTNGGATCNGCCGACGTGCANCTGAANGANTATCCCCGGCTGTNCCACNAGGTGTTCAACGAACCGGANCGCAACCAAGTG :::::::::::::Rv78T7.seq::::::::::::: CAAGGCATACGCCAAGACCCAAGGGATCGCAGTCACCTCCGTCAACGGCCTGGTCGCCGGCCACGGGTCCGTGCAGGAGACGTGGCTGGCCATGCAAAGCGCCGCC (SEQ ID NO. 653) GCCTTATCAGGAACGCCCCGGCTTGTCGGCTTTTCCTGCATCGACACATTTCCGGAGGTGTTGTGGTTGGCGCANCGCGCGAGACAGGCCTGGGATGGCGTGCGCA TCGTCATCGGGAATGCGATGGCAACACTGAACTACGAGCGCATCCTGCGCCAGCATGACTGTTTCGACTACGTCGTCGTTGGCGACGGGGANGTAGCGTTCACCAA GCTGGCCTTGGCCCTGGCGAATGACCTGCGGTTGACGACTCCCGGGACTAACCCGCCGTANTGAGCAAGGACAGATTCTGCGCACACCCTCCTCGCTGGTCGACCT TGACA Clone Rv79 :::::::::::::Rv79SP6.seq::::::::::::: AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTGCCGGTGATCTGGGTGGCCAACTCGGCGGGCACCATCTCCATCACG (SEQ ID NO. 654) ACNGCAAACGCTCCGGCTTCGGCGACAGCGATCGCGTCTGCGATNGTTTGTTCGGCGGCGTCTCCGCGGCCCTGCACCCGGAAGCCGCCCAAGGTGTTGACNCTTT GCGGGGTGAAGCCGATGTGTGCCATCACCGGGATNCCCGCCGCGGTCAGACANGCGATTTGCTCGGCCACCCGCTCACCGCCCTCGANCTTGACNGCATGTGCGCC GCCGTCCTTGAAGAAACCGGTGGCGGNGGCAACCC :::::::::::::Rv79T7.seq::::::::::::: CGTTGAGATCCAGCTGCGCACTGTGCAGCGCCTCGGTGGTCTGCTCGGCCTGCCGGGATAACTCGTTGAGCTTGGCCAGCGCGTCGTCGGCCGGATCAGCCAGCAC (SEQ ID NO. 655) ATTCGCGGCCAGGACGCCGGAGGAGACGGTGAAGCTCGCAAAGAAACCTATGGCGGACCGCATGATTACACGCGCGATCAACCACCTCTGGTCGAGCCTCAAAATT TGCTTCCTTAAACGGGCCATCGACGGATGACGTCGAGCTGGTTTAGGTCTCAAACAGGTTACGAAACGATCTCGGAATTGTCCAAAAGGGGAAGTTAAGAAAATGG ATAGATTTCTACCATTTCGCTGTGGACGATCGTACTTCTGCTATAGGGCTCCAGGGGCATCGACACGCAACGACCTTACGCGACACCGGATCCGCGCTGGCGGCGG AACGGCACCANGCGCAACCGAAGGGCCAATCCGACATCGG Clone Rv7 :::::::::::::Rv7SP6.seq::::::::::::: ATACTCAAGCTTATCTAGGCGCCAGCTTGATTGGTCTGGTTGCATTGGCCAGCTGCGCGAGCCTGGCTCACTTCAACTACAACAACCGCAAACAATTGCCGCCTTC (SEQ ID NO. 656) GGATCCGAGTTCGGTTGGGTACGCGGCAATGGANCACCATTTCTCGGTGAATCAGACTATTCCTGAGTACTTGATCATCCACTCTGCACACGACCTGCGAACCCCG CGCGGCCTTGCCGACCTGGAGCAGCTGGCGCAACGTGTGAGCCANATCCCAGGCGTTGCCATGGTTCGCGGTGTGACCCGGCCAAACGGGGAAACCCTTGAACAGG CCCGGGCGACATACCAAGCCGGCCAAGTTGGCAACCGGCTGGGCGGCGCGTCGCGAATGATCGATGAGCGCACCGGCGACCTGAATCGGCTGGCATCGGGTGCCAA CCTGTTGGCCGACAATCTCGGTGACTTCGCGGTCAAGTCAGCCGGGCCGTTGCGGGTGTCCGCAGCCTTGTCCAGCCCCTCGCTTACTCCA :::::::::::::Rv7T7.seq::::::::::::: CAGGCATGCAAGCTTTTTGAGCGTCGCGCGGGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGC (SEQ ID NO. 657) CCACCCTCATTGGCGATGGCGCCGACGATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGTCAAGTCCGGTCTACGCTTGGGCCTTT GCGGACGGTCCCGACGCTGGTCGCGGTTGCGCCGCGAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCACCGCCGCGGCACTGCACGGCCAGTGCCCGCGGCGA TTCAGCCATCGGGACATCATGCTCGCTTCATACTCCTCGACCAGTCGGCGGAACAGCTCGATTCCCGGAACGCCCACGCATGGTG Clone Rv80 :::::::::::::Rv80SP6.seq::::::::::::: AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTGTAGAAAAAGATCGGTGAGCGCATCGATTCGCTCCGCCGGGTTTGC (SEQ ID NO. 658) CGCTGCGGCGGCGGAGCTGCCGTGACCGTCTATTTGGGTGATCAGATACTGGGCTAGTTCGGTCGGGGTGGGGTGATCGAAGATCGCGGTGGCCGGCAGCGTTACT GCGGTGACAGCTGTTAAGCGGTTACGTATCTCCACGGCACTCAAGGAATTAAATCCCGAATCGGCAAACGCCTGGCCAGCGTCNAGTCCGGCAGCGCCGTCNCGCC CCAGCACCGCTGCGGCATGCTCACATACCACCTCGATCGCTGCGGCGANTTGCTCGTCNGCCGACCGACCGGCCANCCGGGCGGCAAACCCNGAAGACCCAAGAAT TCATCACCACCATCGCTAGC :::::::::::::Rv80T7.seq::::::::::::: CCTTCTTGACACCCACCTCGCCATCGACCTTGAGCACTCCGTCGTAGTTGGTGAACATGTGACCGGCGATCGGGCGGGTGAACGCGTACTGGGTGTCGGTGTCGAC (SEQ ID NO. 659) GTTCATCTTCACCACGCCGTAGCGCAGCGCCTCCTCGATCTCCGACTTAAGCGAACCCGAGCCGCCGTGGAACACGAAATCNAACGGCTTGGCGTCNGCCGGCAGT CCGAGCTTGGCCGCCGCCACCTGTTGCCCTTGCGCAAGGATGTCNGGGCGAANCTTGACGTTGCCGGGCTTGTANACGCCATGCACGTTGCCGAACGTCNCGGCCA GCANGTATTTGCCGTGCTCACCGGCGCCCANCGCCTCGATGGTTTTCTCGAAGTCCTCCGGGCTGGTGTACAGCTTCTCGTTGATCTCGTTCGCCACGCCGTCCTC TTCGCCGCCGACG Clone Rv81 :::::::::::::Rv81SP6.seq::::::::::::: AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTGGAAAGGAGATCCCCGGGAACCTGGTGGCAACCCCGCCATTGGGGT (SEQ ID NO. 660) TGTTGGGATTGCCGATCAGCGTGAANGAAAGCTCGTCTGGAGACAGCGGGTCGGCCGAAGCCGCAAGATTGGCCATCACTAGTGACGANATCGTGGCGCTCTGCGA GTANCCNAAGACAGTGACGTTGTTNCCGGCGGCAATTTGCTGCCGAATCGCACTTTCGAGAATGACNGCACCCTGCGCCACCGANGAATCNAAAGTGAGGTTCTTG ATCACGACCACCGGGTNGAGCCCTTGGGGCGTGAAGANCGCCTGCGCNATAACACCCGGGACGCTGCCACTCATGTNCAGCGCGTTCGCGANCTCNACATATCT :::::::::::::Rv81T7.seq::::::::::::: TCCTGGTGATCGANGGCCGCGGTTCCGGCCGAAAATCCGGTTCGGGTTCGGGTCGCGGTTCCAACTTGANCGCGGTCCGCAGCTGATTCACCGTGGCAACGCCGGC (SEQ ID NO. 661) CAACTGCGCATAATGCGCATCCGAACCCTCACCCGCCCGCCCCGCGATCACCCCAACCTGATCCAACGACAACCGCCCCTCCCGCATACCCCGGGCGCAGCGCGGA AACTCCGGCAACCGCCGCGCCACCGTGGCGATCGTGTGGGCGTTGCCTGACGAACANCCCATCTTCCAGGCCACCAACCCCGCCACCGACCGCGCCCCCGTCACAC CCCACAACCCGTCGCGATCCAGCTCAGCCACGATCTCCACAATGCGCCCATCAATCGCATTGCGCTGAACGGGCAACTCCGCCAACTCCTCCAA Clone Rv82 :::::::::::::Rv82SP6.seq::::::::::::: AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAGATCTGGTACCCATCCGTGATACATTGAGGCTGTTCCCTGGGGGTCGTTA (SEQ ID NO. 662) CCTTCCACGAGCAAAACACGTAGCCCCTTCAGAGCCAGATCCTGAGCAAGATGAACAGAAACTGAGGTTTTGTAAACGCCACCTTTATGGGCAGCAACCCCGATCA CCGGTGGAAATACGTCTTCAGCACGTCGCAATCGCGTACCAAACACATCACGCATATGATTAATTTGTTCAATTGTATAACCAACACGTTGCTCAACCCGTCCTCG AATTTCCATATCCGGGTGCGGTAGTCGCCCTGCTTTCTCGGCATCTCTGATAGCCTGAGAAGAAACCCCAACTAAATCCGCTGCTTCACCTATTCTCCAGCGCCGG GTTATTTTCCTCGCTTCCGGGCTGTCATCATTAAACTGTGCAA Clone Rv83 :::::::::::::Rv83SP6.seq::::::::::::: AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTANCGCCACCTCCCGGGCGGAACTCCACGGCGTGGATNAAGGTACCG (SEQ ID NO. 663) GCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGANGTCCGCGTTAGCGCCGGATTCCACCACATCCCCTTGCGAAANTCCGTTGGGTNCNATGATGTNNC GCTTCTCCCCNTCNANATAATGGANCAACGCNATCCGTGCGGTACGGTTCGGGTCNTACTCCATGTNCGCGACCTTGGCGTTGANACCATCTTTGTCATTGCGGCG AAAGTCNATCATCCGGTNAGCNCGCNTATGANCGCCGCCTTTGTGCCGGGTGGTAATCCGGCCATGCGCNTTGCGTCCACCGCGAACGTGCAACGGGGGCNCCAAC GANTTCTCCNGGGTTGAACCGGTNATCT :::::::::::::Rv83T7.seq::::::::::::: TGTGTGTGGTGGTAACCCATCTGAGCAGTGTGCCAAACCGGGGCAGCCAGCTCCCAATTGACGTGAGCCCGCTCACTTGCTGGGTAAGCGTCG (SEQ ID NO. 664) Clone Rv84 :::::::::::::Rv84SP6.seq::::::::::::: AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATANAATACTCAAGCTTGCGGGTNATNGCCTTGGTCAACGGCACCGTGATCGGATCNGGGTCT (SEQ ID NO. 665) ACCGCACACATNGACTGGAGCTTCGGCGAANTCATCGCCTATGCCTCGCGGGGGGTGACGCTGANCCCNGGTGACNTGTTCNGCTCNGGCACGGTGCCCACCTGCA CGCTCNTCNAACACCTCANGCCACCGGAATCATTCCNGGCTGGCTGCACGANAGCGANNTTGTCNCCCTCCAAAGTCTAAAGGCTGGGCGANANAAGCANAACGTC CCGACNAACGGCACTCCTTTTCCNTTTGCTCTTC :::::::::::::Rv84T7.seq::::::::::::: GAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAAATTCCAATCAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCC (SEQ ID NO. 666) GTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATATGGCGAAAAACGGTCGCCGTTGCACGACATTAAATGTCACGGTATTGTAGATTA AAAAGATACCCACCAACAANGCAATCAAACTGAGAGCGGTTAAATTGACCGTAAAAGCGTCCGTCATCTGTTTGACNGTGTCCCGTTGGGTATCCGACGTTTCCAT ACGCACACCGGCCGGCAGTCTTTGTTGGATGCGTNTTGCAATGGCCTCATCTTTGATGATCAAATCGATGTNGCTCAGTCTTCCGGGCATATGGAACAACTCTTGG GCCGTGGAAATATCAGCAATGATA Clone Rv85 :::::::::::::Rv85SP6.seq::::::::::::: CTTTCGCCCAGGCCGGCGCGGATGTCCTCATCGCTTCACGAACATCATCCGAGCTTGACGCTGTCGCCGAACAGATCCGCGCTGCCGGCCGCCGCGCCCACACCGT (SEQ ID NO. 667) TGCCGCCGATCTGGCCCATCCCGAGGTGACCGCGCAGCTGGCTGGTCAGGCCGTCGGAGCTTTCGGGAAGCTCGACATCGTCGTCAACAACGTTGGCGGCACCATG CCCAACACGCTGCTAAGCACCTCGACCAANGACCTCGCGGACGCCTTCGCCTTCAACGTGGGCACCGCCCACGCGCTGACCGTCGCGGCGGTGCCGTTGATGCTGG AACACTCCGGCGGCGGCAGCGTGATCAACATCAGCTCCACCATGGGCCGGCTGGCGGCGCGGGGTTTC :::::::::::::Rv85T7.seq::::::::::::: TGTGGGCTCCGATCCGGCGCGCATGGCATCGACGGCGACGCCGATCGATGACGGCCAGGCTTACGAGCTTGAGGGTGTGAAGTTGTGGACCACCAACGGTGTGGTA (SEQ ID NO. 668) GCGGACCTGCTAGTGGTTATGGCGCGGGTACCGCGCAGTGAAGGGCNCCGAGGGGGAATCANCGCCTTTGTCGTCGAGGCTGATTCGCCCGGGATCACCGTGGAGC GGCGCAACAAGTTCATGGGACTGCGTGGCATCGAAAACGGCGTGACCCGGCTTCNTCGCGTCAGGGTGCCCAAAGACAACTTGATCGCANGGAAGCGACGGTCTGA AGATCGCGCTGACCACACTCAACGCCGGACGGCTGTCCCTACCGGCGATCCAACCGGAGT Clone Rv86 :::::::::::::Rv86SP6.seq::::::::::::: GAGCTGGCCGAGCTGGACCGGTTCACCGCGGAACTACCGTTCTCGCTCGACGACTTTCAGCAGCGGGCTTGCAGCGCGCTGGAACGCGGCCACGGTGTGCTGGTGT (SEQ ID NO. 669) GCGCGCCGACCGGCGCTGGCAAGACAGTGGTCGGCGAGTTCGCCGTGCACCTGGCGCTGGCGGCCGGCAGTAAATGTTTCTACACCACGCCGCTGAAAGCCCTGAG CAACCAAAAGCACACCGATCTCACAGCACGCTACGGCCGTGACCAGATCTGGCTGCTGACCGGTGACCTGTCNGTCAACGGCAACCGCCGGTGGTGGTGATGACCA CCGAAATGCTGCGCAACATGCTCTAC :::::::::::::Rv86T7.seq::::::::::::: GATCTCTGGATCGGCGGGGCTCTCCGGGCCGGCCTCGGCGACCTCAGCGGGCCGCGCCTTCCGGCCGAACCATTCCCTAGCCATAGATGACCGCACCTCGATGCAC (SEQ ID NO. 670) GGTTTGGCGGCAACGCGGCAAGGCGTCNGTCGGGCCCAGCCGCGGCAATGCGGGTACCCGGGAGCGCGGGTCNGTANACCANCGCTGGACTGCGTCGCGCGGTGCG TCNACNTCAAAGTCCCCGGCGTCCCATATCGCGTATGACGCGGGCGCGCCCGGCACCANGGGTGCCGATCCGGCCGTCTCGAACACCACCGGCCCGCCAGCCGCCG CGGGTCCGGCAGCNAACCCGCCCGCGCCGATACCCGCTGCCCGCGTGCGTGATTGACCGCCGCGCGCACGCTGGCCANGGATCAAAGCCCGTG Clone Rv87 :::::::::::::Rv87SP6.seq::::::::::::: GGACGCGTAGCCCGCCAGGCCGGTCAGGGTGCCCTTCCAGTCCACGCCGCTGTGGTCGGCGAACCGCTTATCTTCAATCGAGACGATCGCCAGCTTCATCGTGTTG (SEQ ID NO. 671) GCGATCTTGTCCGAGGGCACCTCGAACCGGCGCTGCGAGTNCAGCCACGCGATCGTGTTGCCCTTCGCGTCGACCATCGTCGATACCGCAGGCACTTGCCCCTCGA GCAGCTGGGCCGAGCCGTTGGCAACGACCTCAGANGCACGATTGGACATCAGCCCTAGCCCGCCTGCGAACGGGAACGTCAGCGCAGTGGCGACGACACTGGCCAA CAGACAGCACCCAGCCAGCTTCAGAACGGTGATCGCGGCCGGGAAGCGCTCGGGCATGCGTNCTACAGTAGCGACCTCCTGTCACTCCACGTGCCGCTCGGTCCAA TAGAATCTTTCCGCGGGCGGGTGAATCTCTGCNGGATCGGGGCNGGCGC :::::::::::::Rv87T7.seq::::::::::::: GCTCGTTGCCGGCGGCGATCTCGTCGAGCTCGTCTTCCATCGCCGCGGTGAAGTCGTAGTCGACGAGCCGACCGAAATGCTGCTCGAGCAGACCGGTTACCGCGAA (SEQ ID NO. 672) CGCCACCCATGACGGCACCAGTGCACTGCCCTTCTTGTGCACGTNGCCGCGATCCTGGATGGTCTTGATGATCGACGANTAGGTCGACGGGCGGCCGATGCCCAGC TCCTCGAGCGCTTTGACCAGCGACGCCTCNGTGTNNCGGGCCGGCGGGTTGGTGGCATGGCCGTCTGGGGTCAACTCGACNATGTCCAACCGTTGACCCGGGGTCA GATGGGGCAGTCGCCGCTCGGCATCGTCAGCCTCGCCGC Clone Rv88 :::::::::::::Rv88SP6.seq::::::::::::: GTCTTTCGATGGCTGCTTCTTCGGCGCTGACGCTGGCGATCTATCACCCCCAGCAGTTCGTCTACGCGGGAGCGATGTCGGGCCTGTTGGACCCCTCCCAGGCGAT (SEQ ID NO. 673) GGGTCCCACCCTGATCGGCCTGGCGATGGGTGACGCTGGCGGCTACAAGGCCTCCGACATGTGGGGCCCGAAGGAGGACCCGGCGTGGCAGCGCAACGACCCGCTG TTGAACGTCNGGAANCTGATCGCCAACNACACCCNCGTCTGGGTGTACTGCGGCAACNGCAAGCCGTCGGATCTGGGTGGCAACAACCTGCCGGCCAAGTTCCTCG AGGGCTTCGTGCGGACCATCAACATCAAGTTCCAAGACGCCTACAACGCCNGTGGCGGCCACAACCGCGTGTTCGACTTCCCGG :::::::::::::Rv88T7.seq::::::::::::: GCCAGGTCGAGGTCCCATGCGCGTGGGCCATTGATGCTGATCGCCAGGACGTCAAANATTTGGTCCGGCGTCAGCTGGGCGAAAAACGTGGGCCCCAGGACTTGCC (SEQ ID NO. 674) CGGAGCTGCCCGGGTTCCCGTCGCGCAGCTCGGCGGCCCCGGTCAGAAANAAATTGCGCCAGGTCGCACACTCCGCGCCGTANGCCAGCTGCTCCAGGGTGTCGGC ATAGAGCCCGCGGGCCGCAGCGTGCTCGCTGTCGGCGAACACCGCATGGTCGAGAAGCGTTGCCGCCCAACGGAAATCACCTGCGTCNAANGCTTCGCGGGCCAAC TCCAGCACTCGGTCGATG Clone Rv89 :::::::::::::Rv89SP6.seq::::::::::::: NAAACGTTCCGGCTTNGGTGCCGGGCGCTTATTTGCGTCTCTGGGATCACNCTCAGTCGCCGGCGGCTGCCGTTGGGCTATNANTTGCACCGANCCGGAAAATCCG (SEQ ID NO. 675) CACNANAACTGCNAGTAGCGGCCTGCAGAANTGCATCCTCGGCGAANCNGACTACCGGTGGACANCNACAAGCGCCGCCGAACAACGCACTGGCCCGAGGGATNGG CGTCTATCGGCCCCGCCCGTCGAACTNGGAACAGACNGTGCGGTTCTACCGTGATCTGGTGGGAATGCTCNACCANACCTTCCCNANNGCTACGGAACNACGGCGC GATATTCNGCCNTCCCANCTCGAGCCTGACNCTNGATATCGTCGANNCTCACCATCNCGATCNGCTGTGCCGGTNTTGCTCGGACTN :::::::::::::Rv89T7.seq::::::::::::: CGAACGACGAACNCCNCAAGCCATGGTGGTTGGCGCCGTCAAAAGGTCCGCGGTCGCCACTACTGGAAAATCGCCTTGAGCGTCNCTCGACCNCCGCCTCGAGTTG (SEQ ID NO. 676) GGTCNTAACGAAATACCTGATGCCGATCANGTCNACGTCTCCGTCGCNNCAACGTGCAGCGGCGACCCACTCTACNANGTCTCGGTNCCGCCNCGGCCAGNGCACC ACCAGTGACNAATCCNTGCGCCNTCGGGCCNAGCANTCCCGGTGCNACCGNGGTGGGTCCGGCGATGGTNGGGTGTNCTCNNTACNGGAACGCCAGCGCNATCANC ATCGGCANACTCNCGTCGATGTGCCGCGGCGCAACCATCCCCCACAATGATCNGGTGCGTCTGATCAGGCN Clone Rv8 :::::::::::::Rv8SP6D.seq::::::::::::: TTAGGCGTGACGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACT (SEQ ID NO. 677) TTGTGTCGACCCTCAACGCCATTGCCGGC :::::::::::::Rv8T7D4.seq::::::::::::: CGTCACCCCGATGCGCCCAGATCGGGGCTTCGCAGATAAAGCACGAACTGGCGGGCAAAACGTCGATCTCGGAGCCGGAAGGGCAATCAGCCGACCGTCGACGAAC (SEQ ID NO. 678) GACACCGGCGAGACCACTTAGGCAGTGACGGCCT Clone Rv90 :::::::::::::Rv90SP6.seq::::::::::::: CTTTTCNCGATGTCTCATGATNCCNANGGAGAACNNTGCNANCNCNGCCGCTGACNTNGCNCACCGCTNTGGCNGNGGTGACATTGGTGGTGGTTGCGGGCTGCNA (SEQ ID NO. 679) CGCCCGACTCGANGCCGANCCATNTNTTGCGGCCGACCGCNTNTCGTCTCNACCGCANNCCCNATCTCNGCCGCNCCCGGTGGANCTACNGCTNCTTCGCCATCTC TCGCCNATGGCTCCNGCGNNTCGCNCAACGTNTGGTTTGGTNANCTGCCTACCTGGTCNT :::::::::::::Rv90T7.seq::::::::::::: GCTGCGCCAGTCGTTCGGTGCGGTCATGCCGTTGGACCNACCATCGGAGTTAGTTGCCGAACCGCGGACCACCGCAAGCACCCGGTCCTGGTCGCGCACCGCGTCG (SEQ ID NO. 680) GCCAACCGCTTGAGCACCACCACGCCGCAGCCCTCGCCGCGCACGAATCCATCCGCGTTGGCGTCNAANCTGTNGCATCGGTCGGTCGGTGACAGCGCCGACCACT TGGACAGCGCGATGGCGGTGAACGGTNANTAGGTGACCTGCCNCCNCGCCCGCCAATGCCCACCTCCGCTTCACNCATGCGAATGGTCTGACACGCCNAGTGAATT GCCACCAGCGACAACAAAAATCGGTATCTNCNGCGACGGCGGACACGCNATCCCNACTGATACTCGATCCGCCCCACCGCTTGNANCTCCGGGTTCCNGTGCTCAT GTACCNTCATGTCGGTCTGCGCNCGATATTGACGATCGTGTTTCCCACGANNANAGANCCTCATCACGCCGGTTCGAGTGCCG Clone Rv91 :::::::::::::Rv91SP6.seq::::::::::::: CTGTGTGCGGNCGGCGCGATATCGGCCTTTTTACTAACCGAACCCGATGTGGGCTCCGATCCGGCGCGCATGGCATCTACNGCGACGCCGATCGATGACGGCCAGG (SEQ ID NO. 681) CTTACGAGCTTGAGGGTGTGAANTTGTGGACCNCCAACGGTGTGGTAGCGGACCTGCTANTGGTTATGGCGCGGGTACCGCGCAGTGAANGGCACCGAGGGGGAAT CANCGCCTTTGTCGTCTANGCTGATTCTCCCGGGATCACCNTGGAGCGCNCCNCNANTTCATGGGACTGCGTGGCATCCAANACGGCGTGACCGGCTTCATCCNTC NGGGTGCCCAAAGACAACTTGATCNGCNNGGAAGCGACGTCTGAANATCGCGCTGATCNCACTCAACGCCGGACGCTGTCCTACCGGCGATCGCACCGGANTTGCC AANCGGCGCTNANNATNCGCGNGAATGNCCGTCCACNANTGCATGG :::::::::::::Rv91T7.seq::::::::::::: TGGGGTGCCGGGCGCCGAGTTGCGTCCCTGGGATCACGCAGAGTCGCCGGCGGCTGCCGTTGGGCTATGAATTGCACCGAGCCGGAAAATCCGCANCAAAACTGCG (SEQ ID NO. 682) AGTAGCGGCCTGCAGAAGTGCANCCTCGGCGAAACGGAGTACGGTGGACAACGAAAAGCGCCGCCGAACNACGCACTGGCCCGAGGGATTGGCGTCAATCGGCCCC GCCCGTCGAACTTGGAAGANACANTGCGGTTCTACCGTGATCTGGTGGGAATGCTCCAACNNACCTTCNCCGAAAGCTACGGAAGCNACGGCGCGATNTTCGGCCT TCCCAGCTCGACCTGACGCTGGAAATCG Clone Rv92 :::::::::::::Rv92SP6.seq::::::::::::: NGGCNGGGAAGTTAATGCCCTACTGGTTCNATGCTCNCACNTCNCCNGTGACNNCCTGCNCCGACCCGCCGAGGTCCTGNCCGTNACCACCGANCNGGCGATCCGG (SEQ ID NO. 683) GACTCTNGTACGCATCCAACANNGANCAACGTGCACGGGCGGAGTNGTNCCGCCACTTCGNCNATGACGGGGTCGATCCNTTCGACGTCCGTCGCCGCGTCGGTCG AGTGGCGGTCACNCTCCNNGTACTCGACCNCACNGACGAGAGGACTCGANCCCATCTACGTGTGGACGAAACANATCTTCTGTCCNACGACTACACCACCACCCAG GCCATCGCCGNCGCCCGCGANGCCCCTTCGACGCCNTACTGGTCCNGNGGNGGCGCTCTCCGGTTGTCTNNCNCNTGNCGTGTTCCTTCACNCACTGCCCNACATC GANCCCGAGCNATNCNANGTCCGTCAATC :::::::::::::Rv92T7.seq::::::::::::: GGACACTGTTCGCGTGCCCCTCGTCAAAGCCGGAGTGGTCGTGCTGCGCCGGACCCGACCCGACCTTCAGCGGGGGTTCACAGCTCCGTGGGTGCCGTTACTTCCG (SEQ ID NO. 684) ATCGCCGCAGTGTGCGCGTGCCTGTGGCTGATGCTGAACCTCACCGCGTTGACTTGGATCCGGTTCGGGATCTGGCTGGTGGCCGGAACCGCGATTTATGTCNGCT ACGGGCGCCGGCACTCGGCGCATGGCCTTCGGCAAGCNCNANANAACGCGACCCGGAGGTGTTGAACTAGCTTCGCCGCGTATTTACAAATTGCNTTATATGTCTA CACATAAGACGCAAACTGCTCTATTGTCAANTCCCANCGTGGTGTGGCNCATGAAGATGTTTGG Clone Rv94 :::::::::::::Rv94SP6.seq::::::::::::: TCCTTCTCGGTATCGGTTTGGGCTGTCACCANCAGTTGGTAGTTCTTCACGTNCTGTTGTTCGAGCGTCNAGCCGTCGCGCGTGTCNANGTCNCCGGACGCGTATC (SEQ ID NO. 685) CCGCCAGGCCGGTCANGGTGCCCTTCCANTCCACGCCGCTGTGGTCGGCGAACGCTNATCTTCAATCGAGACCATCGCCAGCTTCATCNTGTTGGCGATCTTGTCN NACGGCACCTCNAACCGGCGCTNCTAGTACNCCACNCNATCNTGTTNCCTTCNCGTCNACATCCTCGATNCCNCNTGCACTTTCCCTCGANCNCCTGGGCCGAGCC GTTGGCANTNACCTCNGAGCCCCATTGGACATCANCCCANCCCGCCTGCGAACGGGAACGTCAGCNCNCTGGCGACAACCTGGCCAACAN :::::::::::::Rv94T7.seq::::::::::::: CACNCCGTGATCGCNAGCCCCNGTAGAAATNGTTGAGCCAGTTGGTGCGGCGCTCGTTGCCGGCGGTNATCTCGTCGAGCTCNTCTTCCATCGCCGCGGTGAAGTC (SEQ ID NO. 686) GTACTCGACNCGCCGACCNAAATGCTGCTCNAGCAGACCGGTTACCNNNAACNCCNCCTCNTGACNGCACCAGTGCNCTGCCCTTCTTGTGCACGTACCCGCNATC CTGGATGGTCTTGATGATCNACTANTNTGTCGACGGGCGGCCGATGCCCATCTCCTCNAGCGCTTTGACCAGCGACNCCTCGGTGTATCGGGCCGGCGGGTTNGTG GCATGGCCGTCTGGGGTCANCTCNACNATNTTCANCCGTTGACCCGGGGTCACA Clone Rv95 :::::::::::::Rv95SP6.seq::::::::::::: TGGCCTTCTTGNCANGGGCNNACATNNGCTATNGCGAGCGTGTAACCGATCATCNTCCNGGCGACTGTGGCCTGANCGGCAAGGGTNGCCTNATTCNTCCTCCTGN (SEQ ID NO. 687) GGCATGGTTNCCACACGGAATGNCGGTAAGTCTGGTCGGCAACCTGGCCCGCTGCGGGTTGGGTTCGGATTCGCTCGGCTANTAAGGTGCTCGCCTGGTGTNACNA CTAATCNCNATATACNCTTANCGGGAGTNGNCGTCCCGATCCTNGCCCTGCCGCNGGCGATCNCGTTCGCANCACCGCCACCGGAACTCNCAANGTGCGCTCATCG GGCTCTACGCGCCATCTTCCCCGGATTCTTCGCGGCNGNGTNCCGNGGGACCCCGGACTGTGACNGGCCCAACGGCTCATCATCG :::::::::::::Rv95T7.seq::::::::::::: CCGGATAGCGGTGTCTGAACTTCGCCCGTTCCCTCCANCGCATTGAGCTTCAGCCCGACCGGCAGGTNNGGAGTCGGCATGCGGTCCTTCGCCCCGACCCCGCTGG (SEQ ID NO. 688) CTAAATANCCACCCCCGAGCGCGGTCACGGTCTTTGCACCGGGACGACGCATACCGGCAGCGCGAACATCNCCGCGGGCTGCAGCNTGAACGTCCAATACCANTCN AACAGTGTCCGCGCGTNAAAACCCGANCCGGCGGTCGCTTCNGTAATCAACGGCTCCTGCGCAACCAGCTGCAAGTCGCCGGTGCCACCGGCGTTGACGATCTTCA TGTCTGCGANCTCGCGCACCAGCTCGACGGCCCGGGCA Clone Rv96 :::::::::::::Rv96SP6.seq::::::::::::: CCTCCCGACCACATACAGGCAAAGTAATGGCATTACCGCGAGCCATTACTCCTACGCGCGCAATTAACGAATCCACCATCGGGGCAGCTGGTGTCGATAACGAAGT (SEQ ID NO. 689) ATCTTCAACCGGTTGAGTATTGAGCGTATGTTTTGGAATAACAGGCGCACGCTTCATTATCTAATCTCCCAGCGTGGTTTAATCAGACGATCGAAAATTTCATTGC AGACAGGTTCCCAAATAGAAAGAGCATTTCTCCAGGCACCAGTTGAAGAGCGTTGATCAATGGCCTGTTCAAAAACAGTTCTCATCCGGATCTGACCTTTACCAAC TTCATCCGTTTCACGTACAACATTTTTTAGAACCATGCTTCCCCAGGCATCCCGAATTTGCTCCTCCATCCACGGGGACTGAGAGCCATTACTATTGCTGTATTTG GTAAGCAAAATACGT Clone Rv9 :::::::::::::Rv9SP6.seq::::::::::::: CTTCACNTCCGTACGGCTCGGGTACGCTTCGGTCNCATTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGC (SEQ ID NO. 690) TCACCGGAATCCAACCGGTANAAGGTCGGCGANCGCTCNGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCANAGCCCTCGGGTCCGGCCAGCACTCCGCAGG CTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCACGTANACGGTTCCTTTCCTAAGCAACACCGAANTTTC AGGACCCGAATGCTCCGGGAAACATGTCACGGTAGGTCGGTATTCCGGCTACCGGCTGANCATTGAGCACGCCGGCCAGCACCGCACGAACCAGGCAATCAGCCGC CGCCGCACCCGACCGCGG :::::::::::::Rv9T7.seq::::::::::::: CAGGCATGCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGA (SEQ ID NO. 691) TGGCACGCCACCGCGACACCACCCGGCTGCGCTACGTCGAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCGAGGT CGATACCGATTTGCGCATCCGCAGCCGCACCCTGGACGACAGAACCGTGCCCTACGAATTGCTTGTCGGGCGGGGCCAAAGAACAGCTTGGCATCCTGGCGCGATT GGCCGGCGCGGCGCTGGTCGCCAAGGAAGACCCGTTCCGGTGCTGAT

TABLE 4 End sequences of the polynucleotide inserts cloned in the named recombinant BAC vectors contained in the I-2049 M. bovis strain Pasteur genomic DNA library. RvXXXSP6 corresponds to the SP6 endsequence of the clone RvXXX; RvXXXT7 corresponds to the T7 endsequence of the clone RvXXX. RvXXXIS 1081 corresponds to a region located close to a copy of the IS1081 repetitive sequence (Insertion element) The character <<->> denotes an uncertain base residue. Clone X0001 ::::::::::X0001SP6.seq:::::::::: AAG- TCGGGTTTCCACACGCGCGGTTTGACCCTAGTCATATGTAATCATGTGTACCATGTGCGGGCGCTTTTCGACGGC CGCGAACCACCGGA-ATTTCCTGTGATTTCACTGCATGCGTACCATCTGGCACAATTGAGCA-TTGTCT-TCGCGG TGGTCGG-CGGGTTGCGTGCCGCCTGCTGCGA-ATGCACCA-TAAGCCCGAACCCACCGGCTTGGTGACCACCGC ACGCTGCGTGTGGGGGGTAACCACTCCGCGACCCCAAGGATGGTCATTTCCAATGAACCGGCTGGACTTCGTCC A-A (SEQ ID NO. 692) ::::::::::X0001T7.seq::::::::::: GTCGCGGTTCGATCGACCCGATCTTCACCTCGTAACCTCGATGCTTAGCAGGATCCAGCTTGACCGCGTTTGGCT CTACCCACTCTTTGAGTGGCGCCGTCGCCTGTGCCCCATCGGTGTTCATGACGAACGCTTCGAAAGACTTCCTCT TGTGAGCCGGAATGTCTGCGTAAAGAAGTTCCATGTCCGGGAAGTAGACCCGGTCGCCCTCCACGTGGTACTCC TTCGAGGTCCGCTTCTCGCCGGATCCGATAAACACCGGCCCCAGGCACCGCAGCGTGAGTTCGAACGGCTTCAG GTAGGTGTTCATGCGGCGGACTCCGGGAGTGCGAGAAATAGCGGTCGCGCGTAGCTGTAGACCGGATGGTTTCC GCCCAGGCTGACGTCGAAGATGCCTCCTTGGAAGGGGCGCGA (SEQ ID NO. 693) Clone X0002 ::::::::::X0002SP6.seq:::::::::: AACTCAAGTTTTTACGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCG CAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACC CTGAAACCAGCTTCCATATCCCGCGAC- AACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCGCGTTCTCCACCGACCGGGCCC GGGTGT (SEQ ID NO. 694) ::::::::::X0002T7.seq:::::::::: GTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCA-GCTATCGCACCC GTTATCGGCTGCGAGCAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCA CGACGGAAAGACGCAGATCGCCGTCAAGCATGTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCA TGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGGATAGCGAGGTCAGCGAATTCTCG TGGCAGCTCGAAAGGGTCCTGCCGGTGCCGGT (SEQ ID NO. 695) Clone X0003 ::::::::::X0003SP6.seq:::::::::: TTCGAGTCATGCGCCCGCCTCGACCACGAA-ATGCACGTCGGGTTCGATCGACCCGATCTTCACCTCGTAACCTC GATGCTTAGCAGGATCCAGCTTGACCGCGTTTGGCTCTACCCACTCTTTGAGTGGCGCCGTCGCCTGTGCCCCAT CGGTGTTCATGACGAACGCTTCGAAAGACTTCCTCTTGTGAGCCGGAATGTCTGCGTAAAGAAGTTCCATGTCC GGGAAGTAGACCCGGTCGCCCTCCACGTGGTACTCCTTCGAGGTCCGCTTCTC (SEQ ID NO. 696) ::::::::::X0003SP6.seq:::::::::: GTCATGTGTACCATTTGCGGGCGCTTTTCGACGGCCGCGAAACACCGGAGATTTCCTGTGATTTCACTGCATGCG TACCGTCTGGCACAATTGAGCAGTTGTCTGTCGCGGTGGTCGGCCGGGTTGCGTGCCGCCTGCTGCGAGATGCA CCAATAAGCCCGAACCCACCGGCTTGGTGACCACCGCACGCTGCGTGTGGGGGGTAACCACGCCGCGACCCCA AGGATGGTCATTTCCAATGAACCGGCTGGACTTC-TCAACAA (SEQ ID NO. 697) Clone X0004 ::::::::::X0004T7.seq:::::::::: AACAGCGCGGTTGAACTGATAGGTGCGGCCCGGCTCGAGCAGGCCGGGCCATTTGTTCGATGCGGTTACCGAAA GATCTCTTCGGTGACCTGCCCGCCGCCGGCCAGCTCGGCCCAGTGCCCGGCGTTGGCCGCCGCGGCGACGATCT TGGCGTCCACGGTGGTCGGGG (SEQ ID NO. 698) Clone X0006 ::::::::::X0006T7.seq:::::::::: GCATCTGGGCTGGCGGTGGTTCGCCGCTCCGAAGCCGTCGAACACCATCGCCAGCGCGGCTTCCACATCAACGA CCATTTCGGCCAGCTTGCGGCGCATCAGCGGCTTGTCGATGAGCGCCCCACCGAATGCCCGCCGCTGCCCGGCG TA-CACAGCGATTCGACCAGCGCGCGGCGCGCGTTGCCGAGGGCGAACGAAGCGGTGCCCAACCGCAATCTGTT GGTCAGCTCCATCATGCGGGTGAGTCCCTTGCCG (SEQ ID NO. 699) Clone X0007 ::::::::::X0007SP6.seq:::::::::: ATCGGTTTCCAGCAACAGCCGATCGACGGCTTCGCCCA-GGCCGCTCCCGGGCGACCCGACCATTGCTGTCGCC GCGTAACGCCATCACGGATGACGCGCAGTTCGTCGCTGTCTAGCTCCACCATCGCCTGCACACCGGCGGCCAG- ACCCATTGGCCGTCGCACTCGTA- AGCAGGTAATCCTCGTCGACGGACTCGGTAACCACCGCCGCCAGCTCCGCTGCCAGGTCGGCGGGGTTGACACC GGCGGGCATCGGGATGGACGACGACGCGGTGCTGACGGCGCCTGTC (SEQ ID NO. 700) ::::::::::X0007T7.seq:::::::::: AGCGGTTTCCCA-GCGATGTGCTGTGAGCGCCGCACCACCAGCGCCGACGCTAAGGATGGAACGCACGGCAT CTTCTGACGCGTAACCGCGTTGTGATCGCGAGCTGAGGAGACGGTATGGGGGAGGGTTCTCGGAGGCCATCTGG GATGTTGATGTCTGTCGATCTTGAGCCGGTGCAACTCGTCGGCCCGGACGGTACGCCGACGGCCGAACGCCGCT ACCACCGTGACCTTCCTGAGGAAACGCTGCGTTGGCTCTACGAGATGATGGTGGTCACCCGCGAGCTGGATACC GAATTCGTCAATCTGCACG (SEQ ID NO. 701) Clone X0008 ::::::::::X0008SP6.seq:::::::::: CAAGCTTCCACAGGTAGGGATCGAGGAACAGCGCGTTGAACTGATAGGTGCGGCCCGGCTCGAGCAGGCCGGC CATTTGTTCGATGCGGTTACCGAAAATCTCTTCGGTGACCTGCCCGCCGCCGGCCAGCTCGGCCCAGTGCCCGG CGTTGGCCGCCGCGGCAACGATCTTGGCGTCCACGGTGGTCGGGGTCATGCCCGCGAGCAGGATCGGCGAGCG GCCGGTCAGCCGGGTGAACTTCGTCGAAAGCTTGACCCTGCCGTCGGGGAGGCGAACCACGGTCGGTGCGTAN CTCCACCAAGCCCGGGCAACCTCGGGGGTGGCGCC (SEQ ID NO. 702) ::::::::::X0008T7.seq:::::::::: TGGACCTCATGACAACGCGGCGGCGATTACCCCCGCTACCGCCAGCAGCATGACGGCGGTAGCGAACACCGCC GGATGCAGCGCAGGTGCGTCGATGTGCTCACGGAATCGCCCCGGCACCGCGATCTCGAGGATCACCAGTGCCAC CCCCTGCAGCGCGACACCGACGATTCCGTACACCGCCACGCCGATCAGGCCCTGGGCCAGCTGGCGTATATGGC GGCGATGGTGACGATGGCCAGCGCCACATACATTGTGGCGGCCAGAACCACGGCGTTGGGGCGGCGGTCGATG AACACTAGGCGACGCAGATCGCCCGGGGTCAACAGGTTGACCATCAGAAAGCCTGCGA (SEQ ID NO. 703) Clone X0009 ::::::::::X0009SP6.seq:::::::::: TTTGGTGCGGCCGGCAATCAACTTC- GCTC-CAGCGGTITCCCAGGCGGGATGTGCTGTGAGCGCCGCACCACCAGCGCCGACGCTAAGGATGGAACGCA CGGCATCTTCTGACGCGTAACCGCGTTGTGATCGCGAGCTGAGGAGACGGTATGGGGGAGGGTTCTCGGAGGC CATCTGGGATGTTGATGTCTGTCGATCTTGAGCCGGTGCAACTCGTCGGCCCGGACGGTACGCCGACGGCCGAA CGCCGCTACCACCGTGACCTTCCTGAGGAAACGCTGCGTTGGCTCTACGATATGATGGTGGTCACCCG (SEQ ID NO. 704) ::::::::::X0009T7.seq:::::::::: CGCCCAGGGCCGCTCCCGGGCGACCCGACCATTGCTGTCGCCGCGTAACGCCATCACGGATGACGCGCAGTTCG TCGCTGTCTAGCTCCACCATCGCCTGCACACCGGCGGCCAGGACCCATTGGCCGTCGCACTCGTAGAGCAGGTA ATCCTCGTCGACGGACTCGGTAACCACCGCCGCCAGCTCCGCTGCCAGGTCGGCGGGGTTGACACCGGCGGGC ATCGGGATGGACGACGACGCGGTGCTGACGGCGCCTGTCGCGACGCTGAGCTCGGACACAGCTAGTAAATGTA GCCTAACCTACTTAATGGGTCGCAGCCCCCCGGGGTCGTCGCATGTCCAACGTTGCTCGACTGGAAGAAAATGC TCGTCGGGGAGCAAATGGCACC (SEQ ID NO. 705) Clone X0010 AATACTCAATCCTTGATCGGTTTCCAGCAACAGCCGATCGACGGCTTCGCCCAGGGCCGCTCCCGGGCGACCCGA CCATTGCTGTCGCCGCGTAACGCCATCACGGATGACGCGCAGTTCGTCGCTGTCTAGCTCCACCATCGCCTGCA CACCGGCGGCCAGGACCCATTGGCCGTCGCACTCGTAGAGCAGGTAATCCTCGTCGACGGACTCGGTAACCACC GCCGCCAGCTCCGCTGCCAGGTCGGCGGGGTTGACACCGGCGGGCATCGGGATGGACGACGACGCGGTGCTGA CGGCGCCTGTCGCGACTCTGAGCTCGG (SEQ ID NO. 706) ::::::::::X0010T7.seq:::::::::: GGATGTGCTGTGAGCGCCGCACCACCAGCGCCGACGCTAAGGATGGAACGCACGGCATCTTCTGACGCGTAACC GCGTTGTGATCGCGAGCTGAGGAGACGGTATGGGGGAGGGTTCTCGGAGGCCATCTGGGATGTTGATGTCTGTC GATCTTGAGCCGGTGCAACTCGTCGGCCCGGACGGTACGCCGACGGCCGAACGCCGCTACCACCGTGACCTTCC TGAGGAAACGCTGCGTTGGCTCTACGAGATGATGGTGGTCACCCGCGAGCTGGATACCGAATTCGTCAATCTGC AGCGCCAGGGGGAAGCTGGCGTTGTACACGCCCTGTCGCGGGCAGGAAGCCGCGCAGGTGGGTGCGGCGGCTT GCCTACGCAAAACCGACTGGTTGTTCCCC (SEQ ID NO. 707) Clone X0012 ::::::::::X0012SP6.seq:::::::::: ATCACGACAACAGCGACGGTGTGTCGGATCAGCGGCCCCCGTTGCCGGGCAATGTTGAGGCGTTTCTGCGTCTG GTTGAGGCCGGCTGGGAC- CCGAGGTGGCTCGTCGGCCACATGGGCAGCACACCACCGTGGTGATGCATCTAGACGTGCAGGACCGTGCCGCT GGCCTGCA (SEQ ID NO. 708) ::::::::::X0012T7.seq:::::::::: GCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTTATCGGCTGCGAGCAAATCGCGGTATGCG TTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCAAGCAT GTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTG (SEQ ID NO. 709) Clone X00013 ::::::::::X0013T7.seq:::::::::: TACAAGCGGCACCTCGCCGGTGAACTGACCGTTCGCACGCTGCGCACCGCCGCCGGGCGCGTGCTCGGCGCGC CGGCGGCCCCCGAGGCCTGAGAGGGGAACCAACCATGCAGGTGAACATGACGGTAAACGGCGAGCCCGTCACC GCCGAGGTCGAACCCCGGATGCTGCTGGTCCATTTTCTCCGTGATCAGCTGCGGCTCACCGGAACTCACTGGGG CTGTGATACCAGCAACTGCGGGACATGCGTGGTGGAGGTCGACGGCGTGCCGGTGAAATCCTGCACGATGCTCG CCGTGATGGCCTCCGGGC (SEQ ID NO. 710) Clone X0014 ::::::::::X0014T7.seq:::::::::: AGCGGCTGGTTACGACTCCCTGTITGTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACGCCCG- CC-TCCGATGCTGGAAGCCTACACTGCCCTTGGTGCGCTGGCC-C-GACCGAGCGGCTGCAACTGGGCGC- TTGGTGAC-GCCAATACCTACCGCACCCC-ACCCTGCTGG-CAAA ATCATCACCACGCTCGACTTGGTTAGCGCCGGTCGACGATCCTCGGCATTGGAACCGGTTGGTTT- (SEQ ID NO. 711) Clone X0015 ::::::::::X0015SP6.seq:::::::::: ACGCGCGCCGATCATATCTGCTATGGATGTACAATTCAGCTCTTGCTGTTATACCAGTATATGGTGTACTATTTG ATCTATGCTGACGTGTGAGATGCGGGAATCGGCCCTGGCTCGACTCGGCCGGGCTCTGGCTGATCCGACGCGGT GCCGGATTCTGGTGGCGTTGCTGGATGGCGTTTGCTATCCCGGCCAGCTAGCTGCGCACCTCGGGTTGACCCGA TCGAATGTGTCCAACCATCTGTCGTGTTTGCGGGGCGGGCTGGTA- TCCCAACCTATGAGGGCCGGCAGGTTCGGTAT (SEQ ID NO. 712) ::::::::::X0015T7.seq:::::::::: CCGCGCTGCTGCTGACGTCGGTCGAACGTGCGACACGTCTGCGAATACCGGCCGAACGCTGGGTITATCCACAG GCTGGCACCGACGCCCACGACACACCGGCCGTCGCCGACCGCCACCGACTGCATCGGTCGACGGCCATTCGGAT CGCCGGTGCCCGGGCGCTGGAACTGGCTGGGCTGGGGCTCGATGACATCGAATACGTCGACCTGTATTCGTGCT TTCCCTCCGCTGTCCAAGTCGCCGCAATCGAACTCGGCCTGGACACCGACGATCCTGCCCGCCCGCTGACCGTC ACCGGGGGCCTGACCTTCGCCGGCGGGCCGTGGAGCAATTACGTCACGCACTCCAT (SEQ ID NO. 713) Clone X0016 ::::::::::X0016SP6.seq:::::::::: CAGGCGTGCAATGACCTGCACTGCGCCGGA-A-TCCCTAACCCACTAAACCGGGGCCGCTCACAAGCCGTGCAGC TCGGTCAGCGTCAGGTGCGCGACCAGGAA- TAAATGAGCAGACCCGTGCCGTCAACGATGGTGGCGATCATCGGCCCCGAAACGATGGCCGGGTC ATGCGCAACTTCTTCAGCAGCGGCGGAAGGACGGCACCACCAGCGAC-ACCACACCACGAT (SEQ lD NO. 714) ::::::::::X00016T7.seq:::::::::: GCGAA-CACTTCGTCAACTTCCAGGGCTGCCCGCACCAAGTATTTCGACGAGTATTTCCGTCGGGCCGCCGCCGC CGGCGCGCGGCAGGTGGTCATCCTGGCGGCGGGGCTGGACTCGCGCGCGTACCGGCTGCCTTGGCCCGACGGG ACCACGGTTTTTGAGCTGGACCGCCCGCAGGTCCTTGATTTCAAGCGCGAGGTGCTCGCCAGCCACGGTGCCCA ACCGCGCGCCCTGCGCCGCGAGATCGCCGTCGACCTGCGTGACGATTGGCCACAAGCCTTGCGGGACAGTGGTT TCGATGCGGCTGCACCGTCGGCATGGATTGCCGAAGGGCT (SEQ ID NO 715) Clone X0017 ::::::::::X0017SP6.seq:::::::::: TTGGGC-TTGCCC-CAATA-GGCCCCAATCAAAAGCCGAGCAGGTGGAACCTA-CGCATTCGCCTC-TCGT-TGTGC ACCCGAGCCATCGCACGCGCGGGAATTCCCGGAT-TC-CCGTATTCTCCGGCGGCCGGGCTAACCCATCCCA-GCC GAACGGTTGGCTC-TGCCGTGGGTCCCGTGTTGGCCGATCGGGGCGTCACCGGGGGTGCTCGGGTGCGG TGACCATGGC-AACTGCCCC-ATGGGCCGACCCTGGTGCAGATAAACCTG (SEQ ID NO. 716) ::::::::::X0017T7.seq:::::::::: TGGTGGAGGTCCCCACCAA-ACCCGGCCGTAACTCTGCTCACGGAAATGCGG-CAGGCCGCGCGTAGCACGTGGT ATCCGCCATAAAGGTGCACCTTAAGCACGGCGTCCCAATTCTCGAACGACATCTTGTGGAAGGTGCCGTCGCGC AAGATCCCGGCGTTGCTCACCACACCGTGCACGGCGCCGAATTCGTCAAGCGCGGTCTTGATGATGTTCGCTGC GCCGTCCTCGGTGGCGACGCTGTCGGTA-TTGGCGACCGCCCGGCCCCCCTTGTCGCGAAATCTCGGCGACGAC CTCATCGGCCATCGCCGAACCGGGCCCCCG (SEQ ID NO. 717) Clone X0018 ::::::::::X0018SP6.seq:::::::::: GCCGGCCAAACTGGCCGGCGGGGTTGCTGTC-TCAAGGTGGGTTCCGCCACCAA-ACC CACTCAAGGATCGCAAGGAAAGC- TCAAGGATGCGGTCGCGGCCGCCAAGGCCGCGGTCAAGGAGGGCATCGTCCCTGGTGGGGGA-CCTCCCTCATC CACCAGGCCCGCAAGGCGCTGACCGAACTGC-TGCGTC-C-GACCGGTGACAA-GTCCTCGGTGTCCACGTGT-CTC CGAAGCCCTTGCCGCTCCGTTGTTCTGGATC-CC-CCAAC-CTGGTTGGACGGCTC GTGGTGGTCAACAAGGTCAGCGAGCTACCCGCCGGGCATGGGCTGAACGTGA (SEQ ID NO. 718) Clone X0018 ::::::::::X0018T7.seq:::::::::: CGAACCT- AATTGTCCTGTAATGCCCAGCTCACCAA-GCATGGCTGGTGGCCGGGGCGGTGAAGCCGGCGTCTGCGGCACCG TCCAACTC-ATGTGGAT-GCCGGAATGGGGATGTCCGG-ACGGCGAATCCGTA- TTCGCTTGTCCCGTGAGGCCCAGGTGGATGGGGGGAAGGATC-TGGTGTCCGGGATGAT ATGGGGCCGATGCCGCCGGTTGAAGTCCACTGGATCGGGAATTCGGGAATCGTGAT CCGACGTTCAGGCCGAAC (SEQ ID NO. 719) Clone X0019 ::::::::::X0019SP6.seq:::::::::: CTAACGGAATGAAAGCCCTGGTGGCCGT-TCGGCGGTGGCCGTCGTCGCACTGCTCGGTGTATCTTCCGCCCAAG CTGATCCCGAGGCGGATCCCGGCGCAGGTGAGGCCAACTATGGTGGCCCCCCAAGTTCCCCACGTCTTGTCGAT CACACCGAATGGGCGCA- TGGGGAATTCTGCCCAGCCTCCGGGTCTACCCGTCCCAAGTTGGGCGTACA-CTCCCGCCGCCTCGGGATGGCC GCTGCCGACCCGGCCTGGGCC-AGGTTCTCGCGCTGTCACCGGAAGCCGACACTGCCGGC (SEQ ID NO. 720) ::::::::::X0019T7.seq:::::::::: CCGCGGGACAC-CCTC-ATGCTGCCGCCATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCG CGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTCGATGACGGCATC GCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCG GTCCCGATCGGCCCA-ACGACATCGTGGCGAAGATTCGCCGGGTACGCCGATGATGTGGTGTGTTTGGCGACGC CGGCGTTGT (SEQ ID NO. 721) Clone X0020 ::::::::::X0020T7.seq:::::::::: CTCTGGGACCGGCCACGGTGCC-CCGGCGTTCCCGGACGTGCTGCGCCAGGTGTCCGGCGGCCGCGTGCATGGT GTTCCCGGATCGGCCGCTGGCCAGAGCCCACCGGTGAATCTGGCGCCTGGCCGACCACCGTGCGCCGTAGGCTT GCGATCGTGCAGCGCTGGCGTGGCCAGGACGAGATCCCGACGGATTGGGGCAGATGCGTGCTCACCATCGGGG TATTTGACGGCGTGCACCGCGGGCACGCCGAACTGATCGCGCACGCGGTCAAAGGCGGC (SEQ ID NO.722) Clone X0021 ::::::::::X0021SP6.seq:::::::::: AATACTCAAGCTTTCGTCAGTTCATTGCGCCAGCAGACCAACAA-AGCATCGGGACATACGGA-TCAACTACCCG GCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCAGCGACCAC-TTCAGCAAATGGCCA-CGCG TGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATC-ACATC-TCACCGCCGCACCA CTGCCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGAC- ATCACATCGCCGCGATCGCCCTGTTCGGGAATCCCTC-GGCCGCGCTGGCGGGCTGATTAAC (SEQ ID NO. 723) ::::::::::X002lT7.seq:::::::::: TGCCGCGGATTTGGCTGGGTGCCCAATATTCAGAATCGGGCCTTTCTTTTTGCGCGACAATAAGGTCACAGTAAA CCCTCGTTTTGTGAGATGCGGCCCGGGCCGGGCGAA-TCGACCTCGAGTGAATGGATCTCGAGTGAATGGACAG GGCATCGCCTACGAGTCGCATCCCCATCCAACAGACCGGTGCTCTTGCATCGGACCCTGAAGGTCCCGCACGGA GGGTGTGGTTGCCGGCGCGGGGTCACGGTGCGGTAGCGACGTAGTGTTTGAACGAATTTCTTGATGCTCCAACC TGTITGGTGTTCAATCCAGTTCT (SEQ ID NO. 724) Clone X0175 ...X0175SP6... AA-CTTGCGCGCTCGGCCGGGTC-AGCATCCAGCTGCTCGGCAAGGAGGCCAGCTACC-TCGCTGCGTATGCCCA GCGGTGAGATCCGCCGGGTC-ACGTCCGCTGCCGCGCGACCGTCGGCGAAGTGGGCAATGCCGAGCAGGCAAAC ATCAACTGGGGCAAGGCCGGTCGGATGCGGTGGAAGGGCAAGCGCCCGTCGGTCCGGGGCGTGGTGAT-AACC CGGTC-ACCACCCGCACGGCGGTGGTGAGGGTAAAACCTCCGGCGGCCGTCACCCGGTTAGCCCGTGGGGCAA (SEQ ID NO. 725) ...X0175... A-TCGAAAGTGACCATCTCTACCTTGAGTGCCATACCGCCCGACCCTATGCCTCGGATAGCTCGGCGGAAAGAAA CGCTTGCAGTGCCGCCGAATAGGCGGCTACGTCGTGAGCGCCCATCAACTCTCGCGCGGAGTGCATCGCCAGCT GGGCGGCGCCGACGTCGACCGTGGGGATTCCGGTGCGCGCCGCGGCCAACGGCCCGATCGTCGACCCGCACGG CAGATCGGCGCGATGTTCGTAACGCTGCAThGGCACTCCCGCGCGCTGGCAGGCCAGTGCGAACGCCGCCGCG GTGCGTCCG (SEQ ID NO. 726)

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743 1 12732 DNA Mycobacterium tuberculosis 1 acctgcgctt gcagagatca aatagggcgc atgggtcagc atagtacagg tcgtcgcgca 60 tctttgatgc atcggaataa gatgtcaggc aattaaaaga gaagccacgg cgactcgcgg 120 cattcagcat gtcgagcgtc gcttcgatgt gagcgcacca ttccgtgtcc aacgatttca 180 gacgaacatt gaatattcca ctcgcgacgc tatagtccgc ctcccgatct atgcgcgccg 240 cgcagatgaa gtctgcgttc gcccgacctt cgaaacgtag tgcggccgcg cgcaccattt 300 cgggggagac gtcgatgccg gtgtaatcag ttttgaagcc acgcgcatct aggtagtcca 360 gtagagcccc atagccacag cctagatcgt tgatcgaaaa tgggtccgcc gcattgacaa 420 tgcgcaccag ctggtcaaag cgcaacgcct gcccggcttc gccgttccaa tcgacgccgc 480 gcgggtgccg tgtgcttcga gtttcgatgc gtagtaacgg gccacgtcag cgagcatggt 540 cgttgcgtct tccgccatga agctgcctca cgatttgtgt gtgtgggcgt cggtgcgtgg 600 gtccgagact ataccttcaa cagttgcatg ccgaggctgc ggcgggcaat gacccaaaaa 660 cccgccggca cggttcgccg agcaaggaag cgtggagacg atagataatt tcactggcga 720 cagtacctca aatagtccgg agcctcggct ccgacgttaa agagcagatc cagaatcgac 780 acggcgggct cgaaccctcc ccacaattgc ttataatcgc ggtagccgtc ataatcgaac 840 caagttaccc ggatgctaag ttcgtcgaac acgcgctcat cgacatacga acgggctgag 900 gggccagaga catattcggt cgctgcggcc tgttggcaga ggttggccag tctctcggtc 960 ttgccgtcgg ctaattcgta gtcccacgaa tttgccagtc gcgtgctgat accgagataa 1020 ctgcaaatcg cattcaatag acgcctgttg agtaaggaaa gattcgtgtg ctgttcttcg 1080 aggtaaatcg gcgcgagcca gtcagcgatc tccgcaaaat gagcggccgc gctgtagttg 1140 aattctagtg cccgccagtg cgctttcgcc caatcggtgc cgtcgatcag cgtctcacgt 1200 atcttttgat ggaaacgtcc cttcacctgg acgggaacag ttatccactg taacccctgg 1260 ctcgttttga tccgatttct gtttcgccaa tcacgcttgg tatattgcat gtcatcatag 1320 atgatgaatt catcgacgaa tgcaatcagg tcaaaatatc ctcgccaagg tatgtaattt 1380 gattgaacaa tcgcgacttt cttcaacgcg gtgtctccaa tttagaataa caaatacgtc 1440 gcgcccgcga cagctccgct ggagcgagtt caagcgattc tgcgacatat tcaatatggt 1500 gctcgggaag gccaggatgg gccgcgaccc ggggcgtccg gtgcgcgatg aacgtcgcat 1560 cgtctcctgt gagataattg catccgatca tatagggctg gctgcggcta ggttgctggc 1620 aaaaagatat cgcggccgat ccgtttctgg ttttgtcttg atgatcaaat ccgcttccgt 1680 tcacgagatc gattcctggt cttcccccag cgtcgcgatg tcgataggtg tcgcgctttg 1740 ttcgtacccg cactacgcgg cggcgagaac ctcgccaccg aatcgggatt ggggggagga 1800 taccactcgg tcgaggcccg tcaccggcct tctagcgggt tgaccatcag tgtttgcagg 1860 gccctatccc ggtatggcgc accacgggat cggcagcgtt ccggttgctg gcgtggtacc 1920 tcgttgtggc gccgtggtcc atgtcgattg agtgcgtgga tcagtgtaaa ccgttgcgcg 1980 ccatgttctg taggcactgg ttcgggttgt ggttaggctg cacggttggc aggttaccaa 2040 ccactgagcc cctgggcgga tgtgagctcg gactccgcct atggggtgta attttggcag 2100 attgggccgg gtccccgtgg tgaggactcc tcaaccggat tgggtaagca tgaggtggtg 2160 ctggcagcgg tgtcctggtc gctctcccga gtaggcccgt tgtgactgtc atgtgggcga 2220 gcgggtttgc gcgcgtagga gacgatgatt actacgcacg tgaccaacca caagaacggt 2280 gcccatgtca ccgtggtgaa aacgagtggc gtggtaccga ctaccccttt ggctcccagc 2340 tgtccataga gcggcacgta gaacggctgg cccgggaccg cgacgttgac gatgctcagc 2400 gccacggcca aactcacgca gacgccgacc gcgcggcggc ggtctccatg ggctgcgagt 2460 tggtcgaata tcccagcacc aggaggcccg ttggggtctc gggctaccag tgcagcgatt 2520 ggcaagacga aaacgagata gtagaaggcg acgtccgcgg gggagaaggt ggcggtggcg 2580 agcaacacaa tccccaccat gacaggcggg atacggcgtc cgagcgccag cacggcgacc 2640 acgactatga ctaggacagc aaacccgatc tgcgttcgcg gaccagtgag gaaaccctct 2700 gggatcttgc ccgattgata gttcttgatg ctatcgggga tcagcaggag tgccttgcca 2760 aaggacacgt tccgcgggtc tcgaagccct ccgaacgaac tattgaactt gatgatgccg 2820 tggatcgact gtgcgatcgt ccccgggaag cctcgtggcc acaacagaaa ggctgcgata 2880 ttggacacca ccacgccggt gatcccgata ccagcccacc gccattgtcg agccgccaac 2940 aacaccacgc cgagaacgac gaactgcggc tttaccagga cggccaagat caccgtgatg 3000 gtggcgaggc cccaccgctg tcgggacaac gccacgaagt aagccagcgc gatcggtacc 3060 acgaaccctg tcgagttgcc tcgatcgatg accccccacg ccgggatggc cgcggcgccc 3120 agtgtcacga agatgaccac tcgctccaga ccacgtgccc cccgggccgc ccagatggcg 3180 ggagatatga ccgccatcgt tagggcgacc aggtaacaga tcagccccaa gcgcggcgca 3240 cccagccaat ggctgggtag tccgaaaatc gcatacggta tgcgggcggg ggcccatgca 3300 gcaaccgcgg tcggctggta atcggcgggt agcgagatca ggtagtccgc gggattgggt 3360 tgaatcccgg cggcggcgac catggcgtag tcgctgaagc agtgccgacc gatattcatg 3420 ccccaatcaa gccaacagtc cccagggact accaaaagag tggaaaagac gtcgaccgcg 3480 taccactgac tgagggcgta cgccgtcgcc gccgaaatca ccgacgccag caggatggtg 3540 ccgagcatga gggtgcgctc ggattgggag ccgatcgccc agagccgctc ccggctcgcg 3600 gtcacggcac cgcgcaacac ctccgggggt cgcttcatct ggattctcct cggttctgcg 3660 cgaaacggta gcagagcgcc atggttgcca acgcggtcgc cgggcagtct agaccggatc 3720 ttcctcgtgg caaccgacaa caggacgtcg ttgccgaaag ggcgctgggc accgacatct 3780 aggatgaacc cacagccacg ccccgacgtt atgccatggc gaagagcgac cggcaggagc 3840 gggaacccag tgaagcgagc gctcatcacc ggaatcacag gaccggacgg ctcgtatctc 3900 gctaagctcc cgctgaaggg atatgtggcc gctggtagcc cggccgaggt ctatttctgc 3960 tgggcgacac ggaattatcg cgaattgtat gggttgctcg cggtcaacag catctggttc 4020 aatcacgaat caccgcgtca cggcgagaca ttcatgactc gtaatcctgc accatatcgc 4080 ggtcggcaac gaggcgctga tcgatgcgca gacgctgatg cgccggccca cccggatagg 4140 tatcagtatt ggggcgttcc ggccagcgta cgaggcgtga tcgaccgcgc aatgggtgtt 4200 tgcgttgagt aataatctga accgtgtgaa cgcatgcatg gatggattcc ttgcccgtat 4260 ccgctcacat gttgatgcgc acgcgccaga attgcgttca ctgttcgata cgatggcggc 4320 cgaggcccga tttgcacgcg actggctgtc cgaggacctc gcgcggttgc ctgtcggtgc 4380 agcattgctg gaagtgggcg ggggggtact tctgctcagc tgtcaactgg cggcggaggg 4440 atttgacatc accgccatcg agccgacggg tgaaggtttt ggcaagttca gacagcttgg 4500 cgacatcgtg ctggaattgg ctgcagcacg acccaccatc gcgccatgca aggcggaaga 4560 ctttatttcc gagaagcggt tcgacttcgc cttctcgctg aatgtgatgg agcacatcga 4620 ccttccggat gaggcagtca ggcgggtatc ggaagtgctg aaaccggggg ccagttacca 4680 cttcctgtgc ccgaattacg tattcccgta cgaaccgcat ttcaatatcc caacattctt 4740 caccaaagag ctgacatgcc gggtgatgcg acatcgcatc gagggcaata cgggcatgga 4800 tgacccgaag ggagtctggc gttcgctcaa ctggattacg gttcccaagg tgaaacgctt 4860 tgcggcgaag gatgcgacgc tgaccttgcg cttccaccgt gcaatgttgg tatggatgct 4920 ggaacgcgcg ctgacggata aggaattcgc tggtcgccgg gcacaatgga tggtcgctgc 4980 tattcgctcg gcggtgaaat tgcgtgtgca tcatctggca ggctatgttc ccgctacgct 5040 gcagcccatc atggatgtgc ggctaacgaa gaggtaatga catggcgcaa gcgacatcgg 5100 gcattcgcgc ggcactttcg caacctgctg tgtatgaggc gtatcagcgg attgcgggcg 5160 ctaaaagcgg gcttgcgtgg atcacaaccg accccatcca gtcgttgcca ggcatgcgta 5220 ctctcgacct cggttgctgg ccagcggtga tacacagctc cccgccagtg gacgtgacat 5280 gtacgagaga cggcatgagc gcggaatgtg cgaccgtgcc gtcgagatga ccgacgtcgg 5340 cgctacggca gcccccaccg gacctatcgc gcggggcagc gtcgctcggg tcggcgcggc 5400 gaccgcgttg gccgttgcct gcgtctacac ggtcatctat ctggcggccc gcgacctacc 5460 cccggcttgt ttttcgatat tcgcggtgtt ttggggggcg ctcggcattg ccaccggcgc 5520 cacccacggc ctcctgcaag aaacgacccg cgaggtccgc tgggtgcgct ccacccaaat 5580 agttgcgggc catcgtaccc atccgctgcg ggtggccggg atgattggca ccgtcgcggc 5640 cgtcgtaatt gcgggtagct caccgctgtg gagccgacag ctattcgtcg aggggcgctg 5700 gctgtccgtg gggctactca gcgttggggt ggccgggttc tgcgcgcagg cgaccctgct 5760 gggcgcgctg gccggcgtcg accggtggac acagtacggg tcactgatgg tgaccgacgc 5820 ggtcatccgg ttggcggtcg ccgcggcagc ggttgtgatc ggatggggtc tggccgggta 5880 cttgtgggcc gccaccgcgg gagcggtggc gtggctgctc atgctgatgg cctcgcccac 5940 cgcgcgcagc gcggccagcc tgctgacgcc cgggggaatc gccacgttcg tgcgcggtgc 6000 cgctcattcg ataaccgccg cgggtgccag cgcgattctg gtaatgggtt tcccagtgtt 6060 gctcaaagtg acctccgacc agttaggggc aaagggcgga gcggtcatcc tggctgtgac 6120 cttgacgcgt gcgccgcttc tggtcccact gagcgcgatg caaggcaacc tgatcgcgca 6180 tttcgtcgac cggcgcaccc aacggcttcg ggcgctgatc gcaccggcgc tggtcgtcgg 6240 cggcatcggt gcggtcggga tgttggccgc agggcttacc ggtccctggt tgctgcgtgt 6300 tggattcggc cccgactacc aaactggcgg ggcgttgctg gcctggttga cggcagcggc 6360 ggtagctatc gccatgctga cgctgaccgg cgccgccgcg gtcgcggccg cactgcaccg 6420 ggcgtatttg ctgggctggg tcagcgcgac ggtggcgtcg acgctgttgc tgctgctgcc 6480 gatgccgctg gagacgcgca ccgtgatcgc gctgttgttc ggtccaacgg tgggaatcgc 6540 catccatgtg gccgcgttgg cgcggcgacc cgactgattt gtgccccagg tcgacaaatc 6600 acgccgtctc gtcagtgagc actccgtcct cgggtccgat ccttccagga gacgttgcaa 6660 cctgatttgg ctcaaattgg tgcgcaccga gggtcgggca catcgtaggg tcgcaacagt 6720 cacatgtgtc actgcaccgg gcgacacccg atgtcccggc tctcagcgac agctgtctga 6780 cctgtggttt tgttcccaag ttggtcgtgg ctgtgcggga ttggaggtgg cgtgggggtc 6840 gcgtcgtatg gattctcctc ctcggttccg cgcgaaacgg ccgcaggcgc aatggtcacc 6900 aacttggccg cggtggagtc tagcctcaca ttttcctggt cgcccccgac aaccaggagg 6960 tcgctgcaga acgggcgttc cctacccaca tctactatga agcgacagcg gcgccccgct 7020 gtgatggctg agcatgaccg acagaggcgg gaagacagtg aagcgagcgc tcatcaccgg 7080 aatcaccggc caggacggct cgtatctcgc cgaactgctg ctggccaagg ggtatgaggt 7140 tcacgggctc atccggcgcg cttcgacgtt caacacctcg cggatcgatc acctctacgt 7200 cgacccgcac caaccgggcg cgcggctgtt tctgcactat ggtgacctga tcgacggaac 7260 ccggttggtg accctgctga gcaccatcga acccgacgag gtgtacaacc tggcggcgca 7320 gtcacacgtg cgggtgagct tcgacgaacc cgtgcacacc ggtgacacca ccggcatggg 7380 atccatgcga ctgctggaag ccgttcggct ctctcgggtg cactgccgct tctatcaggc 7440 gtcctcgtcg gagatgttcg gcgcctcgcc gccaccgcag aacgagctga cgccgttcta 7500 cccgcggtca ccgtatggcg ccgccaaggt ctattcgtac tgggcgaccc gcaattatcg 7560 cgaagcgtac ggattgttcg ccgttaacgg catcttgttc aatcacgaat caccgcggcg 7620 cggtgagacg ttcgtgaccc gaaagatcac cagggccgtg gcacgcatca aggccggtat 7680 ccagtccgag gtctatatgg gcaatctgga tgcggtccgc gactgggggt acgcgcccga 7740 atacgtcgaa ggcatgtggc ggatgctgca gaccgacgag cccgacgact tcgttttggc 7800 gaccgggcgc ggtttcaccg tgcgtgagtt cgcgcgggcc gcgttcgagc atgccggttt 7860 ggactggcag cagtacgtga aattcgacca acgctatctg cggcccaccg aggtggattc 7920 gctgatcggc gacgcgacca aggctgccga attgctgggc tggagggctt cggtgcacac 7980 tgacgagttg gctcggatca tggtcgacgc ggacatggcg gcgctggagt gcgaaggcaa 8040 gccgtggatc gacaagccga tgatcgccgg ccggacatga acgcgcacac ctcggtcggc 8100 ccgcttgacc gcgcggcccg ggtctacatc gccgggcatc gcggcctggt cgggtccgcg 8160 ctgctacgca cgtttgcggg cgcggggttc accaacctgc tggtgcggtc acgcgccgag 8220 cttgatctga cggatcgggc cgcgacgttc gacttcgttc tcgagtcgag gccgcaggtc 8280 gtcatcgacg cggcggcccg ggtcggcggc atcctggcca acgacaccta cccggccgat 8340 ttcctgtcgg aaaacctcca gatccaggtc aacctgctgg atgccgccgt ggcggcgcgg 8400 gtgccgcggc tgctgttcct gggctcgtcg tgcatctacc cgaaactcgc cccgcagccg 8460 atcccggaga gcgcgctgct caccggtccg ttggagccga ccaacgacgc gtacgcgatc 8520 gccaaaatcg ccggcatcct tgcggtccag gcggtgcgcc gccaacatgg cctgccgtgg 8580 atctcggcga tgcccaccaa cctgtacggg ccaggcgaca acttttcgcc gtccggctcg 8640 catctgctgc cggcactcat ccgccgctat gacgaggcca aagccagtgg cgcgcccaac 8700 gtgaccaact ggggcaccgg cacgccccga cgggagttgc tgcacgtcga cgacctggcg 8760 agcgcatgcc tgtatctgct ggaacatttc gacgggccga cccatgtcaa cgtgggaacc 8820 ggcatcgacc acaccatcgg cgagatcgcc gagatggtcg cctcggcggt aggctatagc 8880 ggcgaaaccc gctgggatcc aagcaaaccg gacggaacac cacgcaaact gctggatgtt 8940 tcggtgctac gggaggcggg atggcggcct tcgatcgcgc tgcgcgacgg catcgaggcg 9000 acggtggcgt ggtatcgcga gcacgcggga acggttcggc aatgaggctg gcccgtcgcg 9060 ctcggaacat cttgcgtcgc aacggcatcg aggtgtcgcg ctactttgcc gaactggact 9120 gggaacgcaa tttcttgcgc caactgcaat cgcatcgggt cagtgccgtg ctcgatgtcg 9180 gggccaattc ggggcagtac gccaggggtc tgcgcggcgc gggcttcgcg ggccgcatcg 9240 tctcgttcga gccgctgccc gggccctttg ccgtcttgca gcgcagcgcc tccacggacc 9300 cgttgtggga atgccggcgc tgtgcgctgg gcgatgtcga tggaaccatc tcgatcaacg 9360 tcgccggcaa cgagggcgcc agcagttccg tcttgccgat gttgaaacga catcaggacg 9420 cctttccacc agccaactac gtgggcgccc aacgggtgcc gatacatcga ctcgattccg 9480 tggctgcaga cgttctgcgg cccaacgata ttgcgttctt gaagatcgac gttcaaggat 9540 tcgagaagca ggtgatcgcg ggtggcgatt caacggtgca cgaccgatgc gtcggcatgc 9600 agctcgagct gtctttccag ccgttgtacg agggtggcat gctcatccgc gaggcgctcg 9660 atctcgtgga ttcgttgggc tttacgctct cgggattgca acccggtttc accgaccccc 9720 gcaacggtcg aatgctgcag gccgatggca tcttcttccg gggcagcgat tgacgcgccg 9780 gcgcgtcaat ctatttcgac attcgcgtga agacgttttc ccagaatcga ctgttgtagg 9840 cgtagaactc ccggccgcgt aggtaggcat gtgatattcg ccttcccccg aacgggtagc 9900 ggcgatgaag gtcgcccatg cggcgcagat caccgaagac cgcgcttggt tcccggtgcg 9960 agccgacgcc cgtggtgtcg aactcgcaca gcacacaccg aatcgtgacc ggctcgcata 10020 ccagcgcggc ccgcaatatg aattcctggt cggcggcgat cccgaaatca aggtcgtagc 10080 caccgatctt ggccaccagc gatgatccga agaacgatgc ttgatgcgga acaacctgct 10140 tgccggccag gaatttgcgc aggctgaaag gtatcgggcc gcgcacccga tcgagcccga 10200 cgagacgatc catcccgaag ccccacaatt cggacaccgg tcccttgccg gatagcgcct 10260 ccacggcctg ggctaccacg tcgggcccgg aaaaacgatc ggcggagtgc aagaaccaca 10320 acagatcacc cgatgcgtgc gcgatgccct ggttcatcgc gtcgtaccgc ccgccgtcgg 10380 gctcggactg ccaatacgcg aagcctggtt cacacccgga caggtatgcc accacgtcgt 10440 cgccgctgcc accgtcgatt acgatgtgct cgatgcgtcc ccggtagcgt tgcgcccgca 10500 cacttttcac cgtgcgctgc aacccgtcga ggtcgttgaa cgagatcgtt atcaccgaga 10560 cggtcggagc agacgtcacc gagttcccct aggttgctgg cggcgattgt ggatcaccgg 10620 gtcttgatac cgatgaaggt gcctcgaaga ttcgccgcat aggaacctcc gagcaacgac 10680 tcggcgatgc ttggttccaa gttgtcgtac tcctccatca ccaggtcgac gccgacgtct 10740 ttgatggcct gaagtaggtg ctcgcgttga atccagaatg accggcgatt gtcccaggac 10800 gcccattttg cggtgtcgcg ctggccaaac gagcggtcgt cggaaaactc ggtaaaccac 10860 ctaccgggaa gtccctcatg ttcggtgggc gccgagagca tgaacttcac cggcgccggc 10920 cgccgcagca accgatcggt caattgtcgt gccgtcgtgg gcaaccggag ccatttatcg 10980 ctccggttga tgatcgagaa gtgcgtctgg agaatcagca gcttgttcgt taccgacgag 11040 agggtttcca ggtattgctt cggattctcc aggtggtaga agaggccgca gcagaagacg 11100 gtatcgaaga gcccgtggtt ggcgatgttg agggcgttgt cgtggacgaa ccggagattc 11160 ggcaggttgg tcttcgattt gatgtagttg caggccgcca tgttcagctc gcgaacctcg 11220 atcccgagga cctgaaatcc catgcgcgcg aacccgaccg cgtacccgcc ttccaagcag 11280 ccgacatcgg ccaggcgtag gtggctcttg tccccgggaa agacggtttc cagaatcccg 11340 cgcgccgaga tgaaccagga cgattcgtct aacgtgcgcg aggactccgg tatcgtcaag 11400 gttccgtcgt cgaggcgaac gttgtgggcg gtgaattgta ccgcgccggc cgaatgttcc 11460 tgtgccatca cttggttagc cccttcggct ggtcctgggt ttgtcgacat ggtcaggctc 11520 gacagccgcg tcggagccgg gagggccaca catccacgag ccccctgcgg ctcggcgtcg 11580 cggcggcgag cttgcgccac tgggtcttga gccgccgcgc gggtgtcgcc ccgcggtgct 11640 gcagcgccag catggcgatc cggggatggc gcgcgatggt ttcctgcagc gcggcgcgcc 11700 cctccgggcc tggaacgttg gcgatctggc gaaggatcca gtcggccatg acggcgatga 11760 gctcctcgcg cgcggggtct cccgggaaca ggtcgagcat cgcgtcaaac gtcgccgcat 11820 gccccggacc ctgcgtcaac cagaactttg gcgggtccac cacctggttg tgccacatgc 11880 cttgggcgtg gcggcgatac acggccatgg tgtcgggcaa catggcgatg tcgccatgca 11940 ccgcgtgccg gacgtgcaga taccagtcca ggggcatgac gtcggcagga atgtcgtcgt 12000 agcgctcgag gcgacggtac acggccgagt tggtctggat gaagttcatc aagatcaacg 12060 catccaggct caagttgccc cgcacccgaa ccggggggaa cttcgagtcc ttggcatggc 12120 cgtcctccca tatcactcgg acgggatgga agcacaccgt cgtcttgggg tgccggtcga 12180 ggaatgcgac ctgtttgctt agcttcagcg gatcgatcca gtagtcgtcc gcctcgcaca 12240 acgcgacgta ctcgccgcga gcggccgaca gggcgccggt caggttccca ttgaggccga 12300 ggttttcggt cctgaagatc ggccggaaca cgtgcgggta ccgctcggcg tactcacgga 12360 tgatcgccgg ggtggcatcg gtcgacgcgt cgtcggcgac gatgatctcc accgggaagt 12420 cggtttgctg gtcgagaaag ctgtcgaagg cctgacgggc gtagcccgcc tggttgtgag 12480 tggtcgagac gatgctcacc ttggggcaaa gctggggact caccgtcggc ccttttcctg 12540 cgcggccgca agggtattgc gatggcgaac gtgaatcgcc tgtgcccgcc ggccgtcggc 12600 cgtcgtggcc tggtggtcgg cggacgtacg gcacacgctg gcgaagtata gcgagggtgc 12660 actgacgttg ggctcgaacc gcgtggcgcg cggtgtgggc gcaccgtctc gagtcggtgc 12720 tggttggctc gc 12732 2 289 DNA Mycobacterium tuberculosis 2 atactcaagc ttgccgcaat cgaaaccaac ctgtttgtgc cgcaagaaat tacgccgtgg 60 cccggcgccg atcaagaaac gccccggcgc gcggcggtgt cgtcgtatgg catgacgggc 120 accaatgtgc acgccattgt cgagcaggca ccggtgccag cccccgaatc cggtgcacca 180 ggcgacaccc cggccacacc cggtatcgac ggcgcgctgc tgttcgcgct gtcggccagc 240 tcgcaggacg cgctgcggca aaccgccgcg cggctggccg attgggtct 289 3 278 DNA Mycobacterium tuberculosis 3 ttggcgggtt ggccacacac ccgccggtga cggcgacgat gctgggctgg ttgcggccct 60 gcgccaccgc ggcttgcatg ctggttggct gtcttgggac gatcccgaaa tagtccacgc 120 ggatctggtg attttgcggg ctacccgcga ttaccccgcg cggctcgacg agtttttggc 180 ctggactacc cgcgtggcca atctgctgaa ctcgcggccg gtggtggcct ggaatgtcca 240 cgccgttcac ctacgtgacc ttgatgggat ccgggggt 278 4 1280 DNA Mycobacterium tuberculosis 4 ccgacccaga cactgaccgg gcgaccgctg atcggcaacg gcacccccgg ggcggtcggc 60 agcggggcca ccggggcccc cggtgggtgg ctgctcggcg acggcggggc cggcgggtcc 120 ggcgcggcgg gctcgggcgc gcccggcggg gcgggcgggg ctgccgggct gtggggtacc 180 ggcggggccg gcgggatcgg cggagccagc accgtactcg gcggcaccgg cgggggaggc 240 ggggtcggtg ggctgtgggg cgccggtggg gccggcgggg ccggtggaac cggccttgtt 300 ggtggcgacg gcggggccgg tggggccggc gggaccggcg gactgctggc cgggctgatc 360 ggtgccggcg gaggtcacgg cgggaccggc gggctcagca ctaatggcga cggcggggtt 420 ggcggggccg gcgggaatgc cggaatgctc gccgggccgg gcggcgccgg cggagccggc 480 ggtgacggcg aaaacctgga caccggtggg gacggcgggg ccggcggtag cgcagggctg 540 ctgttcggca gcggcggcgc cggcggcgcc ggcggatttg gtttcctcgg tggggacggc 600 ggggccggtg gcaacgccgg gctgctgttg tccagcggcg gggccggcgg gttcggcggg 660 ttcggcaccg ccggtggggt cggtggggcc ggcggcaatg ccggctggct gggcttcggc 720 ggggccgggg gcatcggcgg aatcggcggt aacgctaacg ggggcgccgg tgggaacggc 780 ggcaccggcg gtcagttatg gggtagcggc ggcgccggcg tcgaaggcgg cgcagcctta 840 agcgtcggcg acaccggcgg ggccggtggc gtcggcggca gcgccgggct gatcggcacc 900 ggcggcaacg gcggcaacgg cggcaccggc gccaacgccg gcagccccgg aaccggcggc 960 gccggcgggt tgctgctggg ccaaaacggg ctcaacgggt tgccgtagcc gggcggcacg 1020 gcatggcttc cgggcgtcaa ccactcgccg gtgatgcaga tcggctgcgg agcgggccgc 1080 caaaatgggg gccgccgcgc caggtatctc ggcgaagatc cccggcgctc gagcgctttg 1140 tcagaggccc gtcgcgggtc gtcgtgacga cggctatccg ggcggtgcgg gtttcgcggc 1200 gcgccctgtg cccggcaccg ccgcccgttt gtcggcaacg ccgccgcgac ccgtgagccg 1260 tccagcagct ggcgcctgcg 1280 5 127 DNA Mycobacterium tuberculosis 5 gggcatcggc ggaatcggcg gtaacgctaa cgggggcgcc ggtgggaacg gcggcaccgg 60 cggtcagtta tggggtagcg gcggcgccgg cgtcgaaggc ggcgcagcct taagcgtcgg 120 cgacacc 127 6 434 DNA Mycobacterium tuberculosis 6 aatactcaag cttgcccagc cgtcgatgac aagaaatatg tccgcaaaag actcagcggc 60 cgactttgct cgcagctggc ggtaccgcgc caccgattct atgccgtggt cgcggaaaaa 120 tgcctcccga aatcgcacgg ccgactccag ttcggcgagc atccgcgatg ccagctgcgg 180 ctgcgccctg ccggccacgg cacccacatg cggcagttcg tccacctggg ccagcgcccc 240 gccgccgaat tccaaacaat agaactgcac ccggcccgca tcgtgggtaa cagccaacgc 300 catgatcagc gtccgcagcg cggttgactt gcccgtttgc ggtgcaccta cgaacgcgac 360 attgcctgcg gccccggaca agtcgatcgt gcgcggcacc cgtgactgct ctaacgggcg 420 attgaaattc cgat 434 7 332 DNA Mycobacterium tuberculosis 7 ccacccgtgt aatttgggat gggcaaaaag gcgaagcacc gcgtggccac gaacgccggg 60 agggacaatc tcgggcggtt agggcttctc gcgggaaggc ccgaacgtac ggcgtttcaa 120 cacctcgcgt cgccctccga ccgcgaacat tcggggatgg cagcaacctg ctggcaccct 180 ggccgggcga tgatctgcag cgtcgccgcg ggtagtcgcc gcccgggcgg ctacactctg 240 aaacgcgatg accatcgatg tgtggatgca gcatcccgac gcaacggttc ctacaccgcg 300 atatgttcgc ctcgctgccc cggtggaccg gt 332 8 354 DNA Mycobacterium tuberculosis 8 aatactcaag ctttccgccg atacccgcca tgtcgcgcac atccaggact tctgggggga 60 tccgctgaca gcggcgggat cccaaagtgc ggatgatcgg gccgcctacg tcgtggtgta 120 cctcgtcggt aacaacgaaa ccgaagcgta tgactcggtc cacgcggtgc ggcacatggt 180 ggacaccaca ccgccaccgc acggggtgaa ggcctatgtc accggtccgg cagcactcaa 240 tgccgaccag gccgagggcg gagacaaaag tatcgctaag gtcaccgcga tcaccaacat 300 ggtgatcgca gcaatgttgc tagtgatcta tcgctccgta attaccgcgg ttct 354 9 353 DNA Mycobacterium tuberculosis 9 gtgccgttcc aacccgaatt ggctttcggc gccatcggtg aggacggcgt gcgggtgctc 60 aacgacgacg tcgtccgcgg gacacacctc gatgctgccg ccatggacgc ggtcgaacgc 120 aagcagctga tcgagctaca acgccgcgcg gaacgcttcc gccgcgggcg tgaccgcatc 180 ccgttgaccg ggcggatcgc ggtgatcgtc gatgacggca tcgccaccgg agcgacggcc 240 aaggcggcgt gccaggtcgc ccgggcgcac ggtgcggaca aggtggtgct ggcggtcccg 300 atcggcccag acgacatcgt ggcgagattc gccgggtacg ccgatgaggt ggt 353 10 279 DNA Mycobacterium tuberculosis 10 aatactcaag ctttcggcgg aaacggacac attgcgaata ttgatgacaa aataaaaatc 60 attgatggtt tgagtcacca ggccgatcaa gccttcgccg agccaaattc caatcaagag 120 gcccaagccc gtaccaatca gcccggcaac gagggattcc gtcattatca gccaaaataa 180 ctgctctcgg gttacaccca aacagcgcaa tatggcgaaa aacggtcgcc gttgcacgac 240 attaaatgtc acggtattgt agattaaaaa gatacccac 279 11 376 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 11 tgctcccgaa acctgggggt gtgcctgctc tgtatgcacg gcatacggac atccttcccc 60 tgagacccgc ggtcgaacca gccacgtgtc catcatagng ggtcaacccc ggccaagggc 120 gacggcacgc caagttcgcc gaccgttaac ctagtgctgt tagcttcatt tgctgcgatc 180 aaaacagctg gtcggccgtt aggaactgaa ttgaaactca accgatttgg tgccgccgta 240 ggtgtcctgg ctgcgggtgc gctggtgttg tccgcgtgtg gtaacgacga caatgtgacc 300 gggggaggtg caaccactgg ccaggcgtcg gcaaaggtcg attgcggggg gaagaagaca 360 ctcaaagcca gtgggt 376 12 393 DNA Mycobacterium tuberculosis 12 atactcaagc tttgccgacg agcgggcgat gttgatgacg ggaaacccca gcgcacaacc 60 gacgattttg gcgtagccgg cggacgtctg ctcgattccg atcacgtcgg cgctcgcatc 120 gagcatggcg ccggcgacgg ctagcagcga tccgccgtcg tcgaggagca cgacacgagc 180 cgtacgcccg gccgtaagcc gcgcccagga ttcggcgaaa aaccgttcta cgtggcgggt 240 gtactgggtg tcgaatgatt cgtggggtgc gtaggcgtcg ctgcaatcgt cgacatagat 300 gccgtcgggc cgcatcgcgt cgacaactcc gggtgagtgg aatagcactt gccgatcacc 360 gcgacgttgc gcggatgagg ccgaacccga ata 393 13 272 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 13 tcctatgtcc ctgccgagca ngtgatcgaa cgcggtgaca gatttgtcta tcctggacct 60 gacggtgagg tcgaagtttt ccaggaattc ggcaaaatcg gtaagagcct gaagaattcg 120 gtatcgccgg acgaaatctg cgacgcatac gggggcatat acgcttcggg tttacgagat 180 gtcgatgggg ccgctggagg cttcacgtcc atgggccaca aaggatgttg tcggcgcgta 240 ccgttttctg cagcgggtgt ggcgcttggt cg 272 14 286 DNA Mycobacterium tuberculosis 14 atactcaagc ttgattccgc cgaaaccgac cgtgagcacc ccgccagcca ccacgctcgg 60 gtcgggcgcc gggcccgggc cgccaggctg ctccgctcgg tgatggcacg ccaccgcgac 120 accacccggc tgcgctacgt ctaaccattc caggcggagc tacatcagct cggccgccca 180 gtgttcgggc cctctttcca ggtcgaagtc tataccgata tgcgcatccg cagccgccac 240 cctggagaac agaacgatgc cctactaatg cttgtctggc ggggcc 286 15 357 DNA Mycobacterium tuberculosis 15 ggtacgcttc ggtcgcagtc tgcgagtgat gcatgacgac cgggacctcg tcggcatctt 60 ccatagcccg ccacaccttc agttgctcac cggaatccaa ccggtagaag gtcggcgagc 120 gctcggcatt ggtcatcggg atatgccgct cgggacggtc agagccctcg ggtccggcca 180 gcactccgca ggcttcgtcg gggtggtcgc gacgcgcatg ggccaccatc gcattcacca 240 ggtctgcgcg aatcaccagc acgtagacgg ttcctttcct aagcaacacc gaagtttcag 300 gacccgaatg ctccgggaaa catgtcacgg taggtcggta ttccggctac cggctga 357 16 83 DNA Mycobacterium tuberculosis 16 ggcgtcaacg gtgtcggaac ccgcgtcaag caattggtag gcctgcagtc tgtgaatcag 60 gccgacgctg tggccgccgc ggc 83 17 383 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 17 ggctngcgta cccggtaccg gccgcgggcc taccacgtgc cggaactgga agcgcagtaa 60 gccctcaacg cgccaccgct ttggcccgcg cgcccggcgt aggcgcatcg gcggtggccg 120 tggggcggcg cactgcgacc tcaccagcgg ctttcgagct ttgttcgatc aaccggccag 180 catggtcgan gatgcattcg agaccatatt cgaaattggt ttcatcgggg gccccgatcc 240 gatgccccct cccagttgcg tgagcaanca gcggagtcnt cgcgggatcg atggccacgg 300 ggtgttcaat ggcggatggt ccgctgcccg ccgactggct cttgcgggag aaccgatcta 360 gcaccaccga tccgcgcacg tng 383 18 603 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 18 cgtaatntcg cgcacancca ngacttctgg ggggatcngc tgacagtggt nggatcccaa 60 attgcggatg atcgggccgc cnacgtcgtt gtgtacctcn tcngtcacaa cnaanccgaa 120 ncgtatgact cggtccacgc ggtgcggcac atggtggaca ccacaccgcc accgcncggg 180 gtgaaggcct atgtcaccgg tccggcaaca ctcaatgccg accaggccga ngccggacac 240 nanagtatcn ctaacgtcac cgcgatcacg agcatggtga tcgnncaatg ttnctantga 300 tctatcgctc cgtaattacc gcggttctcg tcttgatcat ggtcgcancg aactccggcg 360 caatccgcgg attcatcgnc ttgctcgccg atcacatatt ttcagccttt cacattgcaa 420 cnaacctgct cgtctcatgg ngatgcggcg acacggacta ccgatatcat gctcgccgtt 480 acacaatcnc gccacgccgc gaagacngga aacgcttcta cacaatnttc ncgggacgcc 540 actnaacttg gttcnggttt gacattgccg cgcatgtntg cccagctttg ccggctcccc 600 tta 603 19 190 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 19 tgaatttccc gatcccacaa tctcggttca gatacaggtc gccatacccc ttacttcggc 60 aacgctgggc ggattggccc tgcngctgca gcanaccatc gacgccatcg aattgccggc 120 aatctcgttc agccaatcca tacccatcga cattccgccg atcgacatcc cggccttcnc 180 cctttaacgg 190 20 506 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 20 aacagctatg accatgntta cgccaagcta tttaggtaac actatanaat actcaagctt 60 ttacggtgat cgcgcatcac ctggttcatg aactggaagc agcgcancgc ttccttttcg 120 gccgcaacat gagccagcct ctcgtccgcg gtcnggtgca ggtgctcggg cagctcggcc 180 gcgacagccg cctgaccctg aaaccagctt ccatatcccg cgacnaacna cnccagtccg 240 ctacgtaacc cctccgcgac tgtccatgga caacagcgcg ttctccaccg accgggcccg 300 ggtgtggggt gtttcggcga ccggcagcca ggtggtccac actgccgacg ggcgccgcga 360 gccgttcacc gaccaagccg ccgaacaagt ccgcccgatc gcatactcca accggttgcg 420 gtactgcagg tcagctggcg tacctcctcn tcncgctcgg cgaagtcttg ctccancacg 480 tcgcagaacg gcaaggaaca cgttca 506 21 388 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 21 gaccgnncca tgtttccaca atgtggtgcc agtncggngg ctacgtgcca tcnanacact 60 ggcgcaggct atcgcacccg ttatcngcta cgaacaaatc ncggtatgcg ttctttanca 120 tgagtcggcg accgncgatc atggtcgaca cccacgacng aaatacgcag atcgccntcn 180 agcntgtgtg ccgcggatta tcangactga cctcctggct gaccggnntg tntggtcgcg 240 atgcctggcg cccggccggc gtgntcgtgg tcggctcgga tagcgaagtc agctaattct 300 cgtggcagct cgaaagggtc ctgccggtgc cggtctttgc gcaaaccatg cncatgttac 360 ggtccctcgg gtgcggcctg gcggcggc 388 22 138 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 22 gggatgggcg ggcccgctaa actcttcgtg ttccactaac tccgggaggg ncaatctcgg 60 gccgttatgg ctcacgtcgc gtcgccctcc gaccgcgaac attcggagtt ggcagcaacc 120 tggtagcacc ctggccgg 138 23 142 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 23 nccgtcgttg acaagtaaat atgtccgcaa aagtctcagc ggccgacttt gctcgcaggt 60 ggcggtaccg cgccaccgag tcgatgccgt ggtcgcggaa gaatgcctcc cgaaatcgca 120 cggccttccc nntttaaacg ga 142 24 441 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 24 tttaggtgac actatagaat actcaagctt ttggtctagc cggccgagca cgatacgggt 60 gtcattggcc accggcggcg gctgtccggg aaatggcggg tccccggtgg ttttgctgat 120 gagtgctgaa ccgtantcga agtgggcggc gtcagactcc acccanccag caggcagcgc 180 gaagctgaat cctccaaccg ggttgtcnat ccggacaagt tggggtgcgt ttggggcaat 240 gacaggtggc ngcggtgcgt tcgggtccgc cggcggaagt gctgcgttgg gatcncccgc 300 tgggcattcg gcntttttgc ggcggccggt ggtngggggg caacaggtnt cccngtgcgg 360 gtggcgctca acggtcnacg gcgcaagccg ccgttgttgg taccnggggc gctggctccg 420 gatcgcgttg gcggtcnccg g 441 25 453 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 25 ctacaccatc gaatacgacg gcgtcgccna ctttccgcgg tacccgctca actttgtgtc 60 gaccctcaac gccattgccg gcacctacta cgtgcactcc aactacttca tcctgacgcc 120 ggaacaaatt gacgcagcgg ttccgctgac caatacggtc ggtcccacga tgacccagta 180 ctacatcatt cgcacggana acctgccgct gctagagcca ctgcgatcgg tgccgatcgt 240 ggggaaccca ctggcgaacc tggttcaacc aaacttgaan gtgattgtta acctgggcta 300 cngcgacccg gcctatggtt attcnacctc nccgcccaat gttgcgactc cgttcgggtt 360 gttcccanaa gtcnncccgg tcgtcatcgc cgaanctctc ntcccgggac ccacagggaa 420 tcngcnattt cncctacaaa tcanccacct cca 453 26 228 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 26 gcatgatcgg ccacctttcg ggccgcccgg catacggcgg cgtaccgatc tccgcgtcat 60 acacccgcgg gtaatcgccg acggtgccgg ttcgcgagcc gaaggtgacg actctgattg 120 aatcgagttc caggtccagc gggtggcgca ccaacggcgc gagctcaacg acgtcaatcn 180 cgttgtcgct ttctacggtc accgaccctg gtgaccgtag ttcncccg 228 27 357 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 27 gacactatag aatactcaag cttgccaacc gccagcctgc atccggcggc gancactgct 60 ccgccgacca gtacgaacca acctgcggtg cccaggccat tgacgatgtg ctggtcggcg 120 cccgcgagtc cgcgcaccat caacgccgcg ggcaccacca nggcggcccc accctgcacg 180 gcgacgatca ttccggcgcc gctcacggcg ggcggggctc gaacangcac agcatcaacg 240 tngtcacccg gccgtgaccg gcccgcatcg tcacaccacc caagcccatt gccgtcctcc 300 tcaacngggc gacccggccc gcatcgtcac acggnctaag gccattgccg tcctcct 357 28 384 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 28 tcggcgccat cggcaccttc gaggacctgt atttcgacgc cgtggccnac ctgaggttgg 60 cggtggacna agtgtgcacc cggttgattc gctcggcctt gccggatgcc acccngcgcc 120 tggtggtcga tccgcnaana gacaanttgt ggtggangct tctgctgcct gcgacaccca 180 cnacgtggtg gcaccgggca gctttagctg gcatgtcctg accgcgctgg ccgacnactc 240 cagacnttcc acnaanggtc gccnncccaa tgtnccgnan tgtctccggn tccctttacc 300 ncccaatggg cngnttccac nggttacggg ccccntnccg gcgggtctnc ctcccaanct 360 accaaatacg cccgacnttc cgga 384 29 266 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 29 atactcaagc ttttatggtg atcgcgcatc acctggttca tgaactggaa gcagcgcagc 60 gcttcctttt cggccgcaac atgagccagc ctctcgtcgg cggtcgggtg caggtgctcg 120 ggcagctcgg ccgcgaacag cccggcttga accctgaaaa ccngctttcc atatcccgcg 180 acgaaagaac gccagttccg ctacttaacc cctccgcgaa ccgtccatgg acaacagcgc 240 gttctccacc aaccgggccc gggtgt 266 30 423 DNA Mycobacterium tuberculosis 30 tcggctcagg ccgcgctgct ggtagagtcg ctgaccggtg caggtttcga caatgtggtg 60 ccggttcggc ggctacgtgc catcgagaca ctggcgcagg ctatcgcacc cgttatcggc 120 tacgaagcaa atcgcggtat gcgttcttga gcatgagtcg gcgaccgtcg tcatggtcga 180 cacccacgac ggaaagacgc agatcgccgt caagcatgtg tgccgcggat tatcaggact 240 gacctcctgg ctgaccggca tgtttggtcg cgatgcctgg cgcccggccg gcgtggtcgt 300 ggtcggctcg gatagcgagg tcagcgaatt ctcgtggcag ctcgaaaggg tcctgccggt 360 gccggtcttt gcgcaaacaa tagcgcaggt tacggtcgcg cggggtgcgg cctggcggcg 420 gcc 423 31 455 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 31 caagctattt aggtgacact atagaatact caagcttcgc gtctacgccg gcccggagca 60 tccgcacagc gctcagcagc cggttccgta cganctcaag caggtggcgc aatgaccgaa 120 accaccccag ccccgcaaac cccggcggcc ccggccgggc ccgcacaatc gttcgtgttg 180 gagcggccca tccanaccgt tgggcgccgt aaggangccg tggtacgaat gcggctggtg 240 cccggcaccg gcaagttcga cctcaacggc cgcagcttgg angactactt cccaaacaag 300 gtgcaccagc agttgatcaa ggcacccctg gtcaccgtgg atcgggtgga aagtttcgac 360 atctttgccc acctgggcgg cggcggccgt ccggtcaggc cgggcctgcc ctgggtatcg 420 cccgggcatt gattctggta tccccngaag aaccg 455 32 371 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 32 cggttggcca ccgcttctgc ggtgccgccg ccgtcgacaa tgaccgtgtc gtccttgctg 60 accaccacgc gtcgggccga gcccagcacc tccaagccca cctcgcgcag caccatgccg 120 gcgtcggggt tgaccacctg gccacccgtc accaccgcca ggtcctcaag gaaacgcctt 180 acggcggtca ccgaagtacg gccccttgac cgcgaccgct ttcaacgtct tgcgaatcgc 240 gttgacgacc agcgtcgcca acgcttcgcc ctccacgtct tcagccacga tcagtagtgg 300 cttacccgtt cctgcaacct tttccagcaa tggcaacaga tcgggaagcg anctgatctt 360 gtcttggtgc n 371 33 320 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 33 ccaagctatt taggtgacac tatagaatac tcaagctttt ggctgggtcg ccttcgaatt 60 cngcgtgcac cgctatgggt tgcancagcg gctggcgccg cacaccccac tggcccgggt 120 gttttcgccc cgaacccgga tcatggtgag cgaaaaggan attcncctgt tcgatgctgg 180 gattcgccac gccaaggcat ctancgatta ctctccncgg ggtgggaaaa gtgcccaatc 240 cccctccctc caactttccn aacaatcatt ccggttccnc cntccggttg gnggtaaccn 300 nccaataaaa cccctgcccg 320 34 383 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 34 gcccgcncat ggccaatccc cgaagacatc attggccagt ggccgggcgc taacaggttc 60 cagcccccca ccantgccgc tcgaacatgc ggtgcaaccc attcgcaggc cggcagggaa 120 agcaccgcgg aagccgcaaa gggctgcagt tccgcgccca ataatgtcgt ccgcaaccag 180 atgcgctcna aaaccncncc ggcagtcagc gcacccgacg cgangtcgaa agacgtcntc 240 agcgcgccca catggggtgc caatcggcac ggcaggtatg ccgcgcgcaa cccgagcgcg 300 tggtgcatgc ccacggtccg cangangcgc ancacccgcc aatgccgaan cccacgaaac 360 atcgggcgca tccaccttca acc 383 35 275 DNA Mycobacterium tuberculosis 35 atactcaagc ttgcccagcc gtcgatgaca agaaatatgt ccgcaaaaga ctcagcggcc 60 gactttgctc gcagctggcg gtaccgcgcc accgagtcga tgccgtggtc gcggaagaat 120 gcctcccgaa ttcgcacggc caattccatt ccgggaagca tccgcaatgc cagctgcggt 180 tgccccctgc cggccacggc acccacttgc ggcattgcgt ccacctgggc cagcgccccg 240 ccgccaaatt ccaaacaata aaaattgcac ccggc 275 36 322 DNA Mycobacterium tuberculosis 36 ccacccgtgt attttgggat gggcaaaaag gcgaagcacc gcgtggccac gaacgccggg 60 agggacaatc tcgggcggct agggcttctc gcgggaaggc ccgaacgtac ggcgtttcaa 120 cacgtcgcgt cgccctccga ccgcgaacat tcggggatgg cagcaacctg gtagcaccct 180 ggccgggcga tgatctgcag cgtcgccgcg ggtagtcgcc gcccgggcgg ctacagtctg 240 aaacgcgatg accatcgatg tgtggatgca gcatccgacg caacggttcc tacacggcga 300 tatgttcgcc tccctgcccc gt 322 37 167 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 37 ctgcccatgt ttggggacgc ccgaccagcc gatgctggag gcctacacgg cccttggtgc 60 gctggccacg gcgaccgagc ggctgcaact gggcgcgttg gtgaccggca atacctaccg 120 cagccngacc cctntcncaa naggatnttg ttcgccggac cccnctc 167 38 287 DNA Mycobacterium tuberculosis 38 ccgactttcc gcggtacccg ctcaactttg tgtcgaccct caacgccatt gccggcacct 60 actacgtgca ctccaactac ttcatcctga cgccggaaca aattgacgca gcggttccgc 120 tgaccaatac ggtcggtccc acgatgaccc agtactacat cattcgcacg gagaacctgc 180 cgctgctaga gccactgcga tcggtgccga tcgtggggaa cccactggcg aacctggttc 240 aaccaaactt gaaggtgatt gttaacctgg gctacgcgac cgccttt 287 39 322 DNA Mycobacterium tuberculosis 39 atactcaagc tttgtcacac caagtgtttc gaccaggcgc tccatccggc gagtggatac 60 tcccagcagg tagcaggtcg ccaccacgct ggtcagtgcg cgttcagctc gcttgcggcg 120 ctgcagcagc cattcgggga aatacctgcc ctggcgcagc tgggggatcc caacttcaat 180 ggttgcggca cgggtgtcaa attcacggtg gcggtagccg ttgccctaat tggaccgctc 240 atcgctgctt tcgcggtacc ccgccccgca cagggcttcg gcttcagccc ccatcagggc 300 ggcaataaac ttcaagagca cc 322 40 471 DNA Mycobacterium tuberculosis 40 gaggcagctt cgccggcaat tctactagcg agaagtctgg cccgatacgg atctgaccga 60 agtcgctgcg gtgcagccca ccctcattgg cgatggcgcc gacgatggcg cctggaccga 120 tcttgtgccg cttgccgacg gcgacgcggt aggtggtcaa gtccggtcta cgcttgggcc 180 tttgcggacg gtcccgacgc tggtcgcggt tgcgccgcga aagcggcggg tcgggtgcca 240 tcaggaatgc ctcaccgccg cggcactgca cggccagtgc cgcggcgatg tcagccatcg 300 ggacatcatg ctcgcgttca tactcctcga ccagtcggcg gaacagctcg attcccggac 360 cgcccagcgc attggtgatg gaatcggcga acttggccac ccgctgggtg ttgacatcct 420 cgacggtggg caattgcgcc tcggtaagct ttgccgcgta gccttttcat c 471 41 247 DNA Mycobacterium tuberculosis 41 atactcaagc ttcactgaca agggacgaat tcgtcggccg cctgttcgac tgggtggtgg 60 ccgagctggt cgccaccact caggccgcgg tcacggcggt accggcgcgg gagcaaactc 120 gcgcgggcat ggccaacttc ttgcggacca tcaccgcaga cgcccgcttc ggacccctgc 180 tgtccaccac acagttggcc aacgcattaa tcacccgcaa gcttgcggaa tccaccgccc 240 tgttcgc 247 42 325 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 42 tccatcaccc gatgtggcng gagcactgcc atgtcgatct caactaccac ctccggccgt 60 ggcggttgcg cgccccgggg ggtccgcgcg aactcgacga ggcggtcgga gaaatcgcca 120 ncaccccgct gaaccgcgac cacccgctgt gggagatgta cttcgttgag gggcttgcca 180 accaccggat cgcggtggtt gccaaaattc accatgcgtt ggctgacggt gttgcctcgg 240 caaacatgat ggcacggggg atggatctgc cgccgggacc ggaggtcggc cgctatgtgc 300 ctgaccccgc tcctaccaag cggca 325 43 221 DNA Mycobacterium tuberculosis 43 agctttgcag ttgctgagta atgtcggcca acgtcaccac aaccgcgatg aattcaatca 60 tgccgcccag ggcggccaac ccaatggtgg ccgcgagcgg cagctcgatc gcagcgcgga 120 ggttgccggc cgccagttga ttcacgaaca gggtgaggtc ataggcgggc aggatagtga 180 cgaaggcaag acctccatct gccgtcggaa gaagtatcga g 221 44 285 DNA Mycobacterium tuberculosis 44 agcttcagaa caggcctgtt gtgggcgcac ccggctcgcc gagttctgca cgcaccgcct 60 caagtgcggc ccgcaccgcc ggcatctccc ggtcacgcag ggccgcggcc cgcgccgcag 120 cgacggcgtg ttcgcgcagt tcgccgtcaa tgatgctgac ctgatcggcc acccgggcgt 180 tctcggcgtc gtcgcgttca ctaatcgcgg tgctcagcag cgtctcgaca gccaccaccc 240 gagtggcgac cagctgctcc accacggacc gcagcgatgc ccgtc 285 45 179 DNA Mycobacterium tuberculosis 45 atactcaagc ttcagttcct ccacgacgcg ttcccaaatg aatttcccga tcccacaatc 60 tcggttcaga tacaggtcgc catacccctt acttcggcaa cgctgggcgg attggccctg 120 ccgctgcacc aaaccatcaa cgccttcaaa ttgccggcaa tctcgttcag ccaatccat 179 46 315 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 46 gctctacgcc gcctacgggt cgaacatgca tcccgagcag atgctcgagc gcgcacccca 60 ctcgccgatg gccggaaccg gctggttacc cgggtggcgg ctgacgttcg gcggcgagga 120 catcngctgg gaaggggcgc ttgccaccgt cgtcnaagac ccaaattcga aggtgttcgt 180 cgtgctctac gacatgaccc cggcggacga gaagaacctt gaccggtggg aaggctccga 240 gttcggtatc caccagaaga tccgatgccg cgtggagcgc atttcctcgg acaccacaac 300 gggatcccgt cctcg 315 47 285 DNA Mycobacterium tuberculosis 47 atactcaagc ttgccaaaga gacctcgtcc accaagcagg acgcgaccgt cgaggtggcg 60 atccggcttg gcgtcgaccc gcgtaaggca aaccagatgg ttcgcggcac ggtcaacctg 120 cccacaccgg cactggttaa gaactgcccg cgtcgcggtt ttcgcggttg gtgaaaaggc 180 caatgcctgc gtttgccgtg ggggcggatg ttgtcgggag tgacaatctg atcaaaagga 240 ttcagggcgg ttggctggaa ttcaatgccg caatcgcgac accgg 285 48 369 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 48 ccacggcgtg gatcaaggta ccggccggga tgttgcgcaa tggcaggttg ttgcccggct 60 tgatgtcggc gttagcgccg gattccacca catccccttg cgaaagtccg ttgggtgcaa 120 tgatgtagcg cttctcccca tcgagatagt ggagcaacgc aatccgtgcg gtacggttcg 180 ggtcgtactc gatgtgcgcg accttggcgt tgacaccatc tttgtcattg cggcgaaagt 240 cgatcatccg gtaagcgcgc ttatgaccgc cgcctttgtg ccgggtggta atccggccat 300 gcgcgttgcg tccaccgcga cgtgcagcgg gcgcaccagc gacttctccg gggttgaccg 360 ggtnatctc 369 49 461 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 49 gcagcatgac ggcggtagcg aacaccgccg gatgcagcgc aagtagcgtc gatgtgctca 60 cggaatcgcc ccggcaccgc gatctcgang atcaccagtg ccaccccctg cagcgcnaca 120 ccgacgattc cgtacaccgc cacgccgatc aggccctggg ccatctgatt ggagctggcg 180 tanatggcgg cgatggtgac gatggccagc gccacataca ttgtggcggc cagaaccacg 240 gcgttggggc ggcggtcgat gaacactagg cgacgcagat cgcccggggt caacaggttg 300 accatcagaa agcctgcgac tagcacggcg gcgccactag gaagtacaag aangtggcca 360 ccaccccatg caggatcggg gtaaggctga tggtcccgaa atcgactccg gcctaataca 420 tgactctctc ctttgcgtca tcgccttact tgtgcgcgga a 461 50 127 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 50 gggacacacc tcgatgctgc cgcnatggac gcggtcgaac gcaagcagct gatcgagcta 60 caacgccgcg cggaacgctt ccgccgcggg cgtgacgcat cccgttgacc ggccggancn 120 ctctcta 127 51 305 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 51 tgggcgcctc tttcggcctt cccnntttaa acgnagcang acattctggg tatcgagttg 60 tactggatgg tgttggcgat gtcggtgatc ctgctcctgg cggtgggatc cgactacaat 120 ctgctgctga tttcccggtt gaaagaggaa attggggccg gattgaacac cggaattatc 180 cgtgccatgg ctggtaccgg gggagtggtg acggctgccg gcatggtgtt cgccgttacc 240 atgtcgttgt ttgtgttcag cgatttgcga attattggtc agatcggtac caccatcgcc 300 ttccc 305 52 449 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 52 ccgatcggcg ccgcanctgg ttggtgttnc ggatgaatcc gcagcgaaaa tgtagctgcg 60 gtggcgtgtc gtgactcgtn ggcgtcgacg ctcgtggcag ccaccgancg gttggtccag 120 gatctggatg ggcaaagttg tgcggcccgg ccggtgacgg ccgatgagct gaccgaggtc 180 gacagcgccg tgttggctga cttggaaccg acatggagtc gccccggttg gcgtcacctc 240 aagcatttca atggttatgc gaccagtttt tgggttacgc cgtcagacat cacgtcggag 300 acttggatga gctgtgtctg ccagatagcc ccgaatcggg acgaccgtgg tcacggtgcg 360 tctgaccact cgggtcgggt cgcccgcgct atcggcatgg gtgcgtnatc acagcgacac 420 gcgcctgccc aaggangtnc ggncggacc 449 53 160 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 53 cgggttgcgg atccacgcgt gcgggttgtc agcagctacg gcactgaacc gcgcccacag 60 ctcgccgatc cgctttcggt ggttctcgat cgactcgccg taggcgatgc gcagcgcctg 120 ctcgaatatc gggtacacgt aggccggcct tcccncttta 160 54 308 DNA Mycobacterium tuberculosis 54 cttgattttg atcatcatga cgatcatcac cctaattttg ctacccgcac tggttatcgt 60 gggtaccgtc gtgctttcca tgggcgcctc tttcgggctt tccgtattgg tctggcagga 120 cattctgggt atcgatttgt actggatggt gttggcgatg tcggtgatcc tgctcctggc 180 ggtgggatcc gactacaatc tgctgctgat ttcccggttg aaaaaggaaa ttggggccgg 240 attgaacacc ggaattatcc gtgccatggc tggtaccggg ggagtggtga cggctgccgg 300 catggtgt 308 55 460 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 55 ggggatccct agatcgacct gcaggcatgc aagcttggcg tgtcgttcca acccgaattg 60 gctttcggcg ccatcggtga ggcgggacac acctcgatgc tgccgccatg gacgcggtcg 120 aacgcaagca gctgatcgag ctacaacgcc gcgcggaacg cttccgccgc gggcgtgacc 180 gcatcccgtt gaccgggcgg atcgcggtga tcgtcgatga cggcatcgcc accggagcna 240 ctgtcaaggc ggcgtgccag gtcgcccggg cgcacggtgc ggacaaggtg gtgctggcgg 300 tcccgatcgg cccagacgac atcgtggcga gattcgncgg gtacgccgat gaggtggtgt 360 gtttggcgac gccggcgtng ttcttcgccg ncgggcangg ttaccgcaac ttcacccaga 420 cctccgacga cgaggtggtg gcgtctcctg gatcgtgctc 460 56 299 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 56 aaggctgcag gtcgaagcgg ntggttacga ctccctgtgt gtgatggacc agttctacta 60 tctgcgtcta cacggccctt ggtgcgctgg ccacggcgac cgagcggctg caactgggcg 120 cgttggtgac cggcaatacc taccgcagcc ccgaccctgc tggcaaagat natcaccacg 180 ctcgacgtgg ttagcgccgg tcgagcgatc ctcggcattg gagccggcgg gtttgaactg 240 gaacaccgcc agctcggctt cgagtccggc acttccagtg accggttcaa ccggctcga 299 57 373 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 57 ctttccgcgg tacccgctca actttgtgtc gaccctcaac gccattgccg gcacctacta 60 cgtgcactcc aactacttca tcctgacgcc ggaacaaatt gacgcngcgg ttccgctgac 120 caatacggtc ggtcccacga tgacccagta ctacatcatt cgcacggaga acctgccgct 180 gctacagcca ctgcgatcgg tgccgatcgt ggggaaccca ctggcgaacc tggttcaacc 240 aaacttgaag gtgattgtta acctgggcta cggcgacccg gcctatggtt attcgacctc 300 gccgnccaat gttgcgactc cgttcgggtt gttccagang tcagcccggt cgtcatcgcc 360 gacgctctcg tcn 373 58 338 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 58 cggtcatagc cctcgggtcc ggccagcact ccgcaggctt cgtcggggtg gtcgcgacgc 60 gcatgggcca ccatcgcatt caccaggtct gcgcgaatca ccagcacgta gacggttcct 120 ttcctaagca acaccgaagt ttcacgaccc gaatgctccg ggaaacatgt cacggtaggt 180 cggtattccg gctaccggct gagcattgag cacgccggcc agcaccgcac gagccaggca 240 atcagccgcc gccgcaccga tcgcggtgac cagctgagtc tccggagaca atgcggccgg 300 cacgccggnc tccggcggca ccgctacngc gcccgtgg 338 59 374 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 59 gtgatggcac gccaccgcga caccacccgg ctgcgctacn tcgagccata ccgggcggag 60 ctacatcggc tcggccgccc agtgttcggg ccctctttcg aggtcgaggt cgataccgat 120 ttgcgcatcc gcanccgcnc cctggacgac agaaccgtgc cctacgagtg cttgtcgggc 180 ggggccaaag aacagcttgg catcctggcg cgattggccg gcgcggcgct ggtcgccaag 240 gacgacgccg ttccggtgct gatcgacgac gcgctggggt tcaccgatcc ggagcgacta 300 tcaagatggg ggaggtctct gacaccatcg gccccnacgg acatgtgatc gtgccgacgt 360 gcagtcccac cccg 374 60 448 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 60 gcgaaagtcc gttgggtgca atgatgtagc gcttctcccc atcgagatag tggagcaacg 60 caatccgtgc ggtacggttc gggtcgtact cgatgtgcgc gaccttggcg ttgacaccat 120 ctttgtcatt gcggcgaaag tcgatcatcc ggtnngcgcg cttatgaccg ccgcctttgt 180 gccgggtggt aatccggcca tgcgcgttgc gtccaccgcg accgtgcagc gggcgcacca 240 gcgacttctc cggggttgac cgggtgatct cggcgaaatc agatacgctg gcgccgcgac 300 gaccaggcgt cgtgggcttg tncttgcgaa ttgncatgtc taatcangtc tttctctcac 360 gctctcgtcg ccgggctagg ccgcattgcc ctgctcctcc tcatcgcttc gctctgcatc 420 gtccccgggc taagcccgtg ccccgaaa 448 61 356 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 61 gatggttcgc ggcacggtca acctgccaca cggcactggt aagactgccc gcgtcgcggt 60 attcgcggtt ggtgaaaagg ccgatgctgc cgttgccgcg ggggcggatg ttgtcgggag 120 tgacgatctg atcgagagga ttcagggcgg ctggctggaa ttcgatgccg cgatcgcgaa 180 caccggatca gaatggccaa agtcggtcgc atcgctcggg tgctgggtcc gcgcggcctg 240 atgcccaacc cgaaaaccgg caccgtcacc gccgactccc catggcgtcc cggatatcaa 300 gggccggcaa atcaacttcc cggttgatca gcaaggcaac ctgcctccnc ctccgg 356 62 336 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 62 atactcaagc ttcgtcataa gaccatggtg cgctttcttt cacccgtcca gagtcggggg 60 catccgcacc ggctcgcatc gcatcatcct cccacgacgg gccgctcatc agcttgggcc 120 atttcaatgt acttgatacc ccgcgctgcg ggtaggccac tgcgacaatt caaacacggt 180 gtcacacggt gaatagtgtc gagatgggct ctgatcaacc gtcgcaaacc cggtttcgca 240 tcaatagcgg aatcccaccg ggttgcatgg aggctgctga ccttggaaaa caaaattttt 300 tcattacaac aaaacaaccg ccncggaaac tttgca 336 63 489 DNA Mycobacterium tuberculosis 63 cgaattcggc gtgcaccgct atgggttgca gcagcggctg gcgccgcaca ccccactggc 60 ccgggtgttt tcgccccgaa cccggatcat ggtgagcgaa aaggagattc gcctgttcga 120 tgctgggatt cgccaccgcg aggccatcga ccgattactc gccaccgggg tgcgagaggt 180 gccgcagtcc cgctccgtcg acgtctccga cgatccatcc ggcttccgcc gtcgggtggc 240 ggtagccgtc gatgaaatcg ctgccggccg ctacctgcaa ggtgattctg tcccgttgtg 300 tcgaagtgcc tttcgcgatc gactttccgt tgacctaccg gctggggcgt cggcacaaca 360 ccccggtgag gtcgtttttg ttgcagttgg gcggaatccg tgctctgggt tacagccccg 420 aactcgtcac ggcggtgcgc gccgacggag ttgttatcac cgatccgttg gccgtaccgc 480 gccttgggc 489 64 448 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 64 tcagactcca cccagccagc aggcagcgcg aagctgaatc ctccaaccgg gttgtcgatc 60 cggacaggtt ggggtgcgtt tggggcaatg acaggtggcg gcggtgcgtt cgggtcggcc 120 ggcggaggtg ctgcgttggg atcgcccggc tgggcattcn gcgtgttggc ggcggccggt 180 ggtggggggg caacaggtgt cgccggtgcg ggtggcgctg cagcggtcga cggcggcgaa 240 gcggccgttg tgggtaccgg gggcgctggc tccggatcgg cgttggcggt cgcgggcacc 300 gcaacggtca ccaagctggc gctggccatc gccgcgatag ccagtgccgc caatcgtccc 360 ttgcgacgtg tcaagtnggg gtccacctga tgcatggcca aagaacctac cgtgttaacg 420 gcncaacnca aggaccgcgc cggtcgcn 448 65 346 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 65 tttccgcggt acccgctcaa ctttgtgtcn accctcaacg ccattgccgg cacctactac 60 gtncactcca actacttcat cctgacgccg gaacaaattg acgcagcggg tccgctgaac 120 aattcggtcc gtcccacgaa agaaccagtt ttncntcttt cncacggaga acctgccgct 180 gctagagcca ctgcgatcgg tgccgatcgt ggggaaccca ctggcgaacc tgtgtttcaa 240 ccaacactta gagtgtaatt gtaaacctgg gctaggggaa accggctcta gtttttccac 300 cntctccgcc ccntgtttcg aatactccgt tcgggttgtc cccaaa 346 66 277 DNA Mycobacterium tuberculosis 66 gcttccggct cgtatgttgt gtggaattgt gaccggatac caatttcaca caggaaacag 60 ctatgaccat gattacgcca agctagttag gtgacactat acaatactca agcttgccgg 120 ctggtgggcc gaccacttcg atggcacgac ccgtgaactg ctgcccggcc aattcttctt 180 ggtcgcccgg accgatggac cgcggctggg attccagaag gtgcccgatc ccgcccctgg 240 gaaaaaccgc gtgcacctct acttcacgac caacgac 277 67 434 DNA Mycobacterium tuberculosis 67 ccgatcgact gatgcgccga caaccacgcc ccaacaactg gaatgaaccg tcgtgaccat 60 catcagcacg cggttgtagg cgacttgcga catgttcaac ccgccgtact cggacggaat 120 cttcaaaccg aaacagccca gctcggccag gcctttcacg tactcgtcgg ggatctgggc 180 accacgctcg aggacgctgc cgtccacggt gtctaggaat tcccgcagtt tgaccagaaa 240 cgcctcggtt cgggcctcct cggcgtccga cggcttggga aatgggtgta tgagccctac 300 gggaaaccgg cccacaaaga gttctttggc gaaggacggt ttatcccaac cactttcgcg 360 agattcctcg gcaagggccc gcgcttgctc ctcggtgacc tgagtttgct gtgccatcgc 420 cgcctcctcc ctga 434 68 465 DNA Mycobacterium tuberculosis 68 tgcatccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca 60 gctatgacca tgattacgcc aagctattta ggtgacacta tagaatactc aagcttttac 120 ggtgatcgcg catcacctgg ttcatgaact ggaagcagcg cagcgcttcc ttttcggccg 180 caacatgagc cagcctctcg tcggcggtcg ggtgcaggtg ctcgggcagc tcggccgcga 240 cagccgcctg accctgaaac cagcttccat atcccgcgac gaacgacgcc agtccgctac 300 gtaacccctc cgcgactgtc catggacaac agcgcgttct ccaccgaccg ggcccgggtg 360 tggggtgttt cggcgaccgg cagccaggtg gtccacactg ccgacgggcg ccgcgagccg 420 ttcaccgacc aggccgccga gcaagtccgc ccgatcgcat actcc 465 69 463 DNA Mycobacterium tuberculosis 69 gggggcgctg ctggtatagt cgctgaccgg tgcaggtttc gacaatgtgg tgccggttcg 60 gcggctacgt gccatcgaga cactggcgca ggctatcgca cccgttatcg gctacgagca 120 aatcgcggta tgcgttcttg agcatgagtc ggcgaccgtc gtcatggtcg acacccacga 180 cggaaagacg cagatcgccg tcaagcatgt gtgccgcgga ttatcaggac tgacctcctg 240 gctgaccggc atgtttggtc gcgatgcctg gcgcccggcc ggcgtggtcg tggtcggctc 300 ggatagcgag gtcagcgaat tctcgtggca gctcgaaagg gtcctgccgg tgccggtctt 360 tgcgcaaacg atggcgcagg ttacggtcgc gcggggtgcg gcctggcggc ggccagagca 420 cgagttcacc gatgcgcagc tagtggcgac agcgtcagcc aac 463 70 447 DNA Mycobacterium tuberculosis 70 tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca 60 gctatgacca tgattacgcc aagctattta ggtgacacta tagaatactc aagcttccgt 120 acaggtcgcc tccaacacgg cggggaagcg acaccagcct accgagcttg gagtccagga 180 cgccagcggc ggcgtcggtc tgcgtcgtgg tgccgccggg gtggcgttgg ctggcaacga 240 tctccaccca gccggtcggg ttacccacga tctcggcata gacgcgggcc gaggccggtg 300 cgataccgta ttgcgtcaat tgggacgcgg ttgtgcattc ggctagctcg gttgccacac 360 ccgtcagggg ttcgacgttg gcgggttcgg cgggccccag caccgctgtc accatgcccg 420 ccaagccgac ctgcggcgcc accaact 447 71 460 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 71 cggcatgacc accgacaggc ccgactggtc gtaccactcg aacgccgggg tgttgatgtc 60 ccagccgctg aagtcgtcct gcgcgcgcag gccgtcgagc aggtacaggg cgggcgagtt 120 ggcaccacca ctttggaatt ggaccttgat gtcacggccc atcgacggcg acggcacctg 180 caggtactcc accggcaagc ccggccggga aaatgccccc gcggtcgccg tgccaccgac 240 ggcgccgacc agacccgaca ctagggccgc gccgacggcc ccgaccacga gtcgacgcga 300 catacccgtg acggcgccac gaaccctgtc aacaagctgc attcttgctt ccctcatcct 360 catctcaacg catccatgca tgtttgggcg catcctgaat tangtcagac tgcaggcgct 420 gggccggcag tgctcgtgta tcaaccacaa cttcgggcgt 460 72 404 DNA Mycobacterium tuberculosis 72 ttccaaccct aattggcttt cggccccatc cgtgaggacg gggtgcgggt gctcaacaac 60 aacgtcgtcc gcgggacaca cctctatgct gccgccatgg acgcggtcca acgcaagcag 120 ctgatcgagc tacaaccccg cgcggaacgc ttccgccgcg ggcgtgaccg catcccgttg 180 accgggcgga tcgcggtgat cgtcgatgac ggcatcgcca ccggagcgac ggccaaggcg 240 gcgtgccacg tcgcccgggc gcacggtgcg gacaaggtgg tgctggcggt cccgatcggc 300 ccaaacgaca tcgtggcgag attcgccggg tacgccgatg aggtggtgtg tctggcgacg 360 ccggcgttgt tcttcgccct cgggcagggt taccgcaact tcac 404 73 465 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 73 caggcatgca agctttccgc cgatacccgc catgtcgcgc acatccagga cttctggggg 60 gatccgctga cagcggcggg atcccaaagt gcggatgatc gggccgccta cgtcgtggtg 120 tacctcgtcg gtaacaacga aaccgaagcg tatgactcgg tccacgcggt gcggcacatg 180 gtggacacca caccgccacc gcacggggtg aaggcctatg tcaccggtcc ggcagcactc 240 aatgccgacc aggccgaggc cggagacaaa agtatcgcta aggtcaccgc cgatcacnag 300 catggtgatc gcagcaatgt tgctagtgat ctatcgctcc gtaattaccg cggttctcgt 360 cttgatcatg gtcggcatcg actcggccaa tccgcggatt catcgccttg ctcgccgaac 420 acaacatttt cacctttcac atttgcacca acctgctctt ctcat 465 74 387 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 74 cactactcaa gctctctcnt cattaccacc cctgtaattt gggatgggca aaaaggcgaa 60 gcaccgcttg gccacnaacg ccgggaggga caatctcggg cggctatggc ttctcccggg 120 aaggccccaa cgtacggcgt ttcaacacgt cgcgtcgccc tccgaccgcg aacattcggg 180 gattggcacc aacctgntac caccctggcc gggcgatgat ctgcagcgtc gccgcgggta 240 gtccccgccc gggcggctac agtctgaaac cccgatgacc atcgatgtgt ggatgcagca 300 tccgacgcaa cggttcctac acggcggata tgttctcctc gctgcgccgg tggaccggtg 360 ggtctatccc ctgaaaccga catcccn 387 75 445 DNA Mycobacterium tuberculosis 75 caggcatgca agctttcgtc agttcattgc gccagcagac caacaagagc atcgggacat 60 acggagtcaa ctacccggcc aacggtgatt tcttggccgc cgctgacggc gcgaacgacg 120 ccagcgacca cattcagcag atggccagcg cgtgccgggc cacgaggttg gtgctcggcg 180 gctactccca gggtgcggcc gtgatcgaca tcgtcaccgc cgcaccactg cccggcctcg 240 ggttcacgca gccgttgccg cccgcagcgg acgatcacat cgccgcgatc gccctgttcg 300 ggaatccctc gggccgcgct ggcgggctga tgagcgccct gacccctcaa ttcgggtcca 360 agaacatcaa cctctgcaac aacggcgacc catttgttcg gacggcaacc ggtggcaacg 420 cacctaagct acttgcccgg gatga 445 76 345 DNA Mycobacterium tuberculosis 76 gtttatgcac tggttaggtg tttccatgag tttcattctg aacatccttt aatcattgct 60 ttgcgttttt ttattaaatc ttgcaattta ctgcaaagca acaacaaaat cgcaaagtca 120 tcaaaaaacc gcaaagttgt ttaaaataag agcaacacgt acacaaggag ataagaagag 180 cacatacctc agtcacttat tatcactagc gcccgccgca gccgtgtaac cgagcatagc 240 gagcgaactg gcgaggaagc aaagaagaac tgttctgtca gatagctctt acgctcagcg 300 caagaagaaa tatccaccgt ggggaaaaac tccaggtaga ggtac 345 77 139 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 77 atactcaagc ttgggtgtag ccgatcaccg gaagtcncat gatcagccac gttccgcgcc 60 gcccggcata cggtggtgta ccgatctccg cgtcatacac ccgcgggtaa tcgccgacgg 120 tgccggttcg cgagccgaa 139 78 298 DNA Mycobacterium tuberculosis 78 agctttatcg aaagcgcgaa cagctcgcgg cggcccacga cgtgctgcgt cggattgccg 60 gcggcgagat caattccagg cagctcccgg acaatgcggc tctgctggcc cgcaacgaag 120 gactcgaggt caccccggtg cccggggtcg tggtgcacct gccgatcgca caggttggcc 180 cacaaccggc cgcttgatgc ccggtcggca agcccggcag ttgccaaacc catcgtgatc 240 aggctcggct cgcgagttcg gcgaagaaat ggttcgcctg atcacctacc atcggcca 298 79 300 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 79 tcaacacgcc gccagccacc acgcgcgggt cgggcgccgg gcccgggcct ccaggctnct 60 ccgctcggtg atggcacgcc accgcgacac cacccggctg cgctacgtcg agccataccg 120 ggcggagcta catcggcccg gccgcccagt gttcgggccc tctcgcccag gtcgaggtcg 180 acaccgattt gcgcatccgc agccgcaccc tgcgacgaca gaaccgcggc cctacccact 240 gcttgtcggg cgggggccaa agaaccagct tgncatcctg ccacaattgg ccggcgcccg 300 80 321 DNA Mycobacterium tuberculosis 80 caggcatgca agcttcacgt ccgtacggct cgggtacgct tcggtcgcag tgtgcgagtg 60 atagatgacg accgggacct cgtcggcatc ttccatagcc cgccacacct tcagttgctc 120 accggaatcc aaccggtaga aggtcggcca gcgctcggca ttggtcatcg ggatatgccg 180 ctcgggacgg tcagagccct cgggtccggc cagcactccg caggcttcgt cggggtggtc 240 gcgacgcgca tgggccacca tcgcattcac caggtctgcg cgaatcacca gcacgtagac 300 ggttcctttc ctaagcaaca c 321 81 340 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 81 aatattcaag ctttcggcgg aaacggacnc cttgcgaaca ttgataacaa aatagaaatc 60 attgatggtt tgagtcacca ggccgatcaa gccttcgccg agccaaattc caatcaagag 120 gcccaagccc gtaccaatca gcccggcaac gagggattcc gtcnttatca gccnaaataa 180 ctgctctcgg gtaccaccca aacagcgcaa tatggcgaaa aacggtcgcc gttgcacaac 240 attaaatgtc tcggtattgt tgattaaaaa gatacccacc accagggcaa tccaactgag 300 agcggttaaa ttgaccgtaa aaacctcccg tcatctgttt 340 82 394 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 82 caggcatgca agcttgctgc atcttcctgt gactgctccc gaaacctggg ggtgtgcctg 60 ctgtgtatgc acggcatacg gacatccttc ccctgatacc cgcggtcgaa ccagccacgt 120 gtccatcatc aggggtcaac cccggccaag ggcgacggca cgccaagttc gccgaccgtt 180 aacctagtgc tgttagcttc atttgctgcg agcaaaacag ctggtcggcc gttaggaact 240 gaattgaaac tcaaccgatt tggtgccgcc gtaagtgtcc tgtctgcggg tgcgctggtg 300 ttgtccgcgt gtggtaacga cgacaatgtg accgggggag gtgcaaccac tggccaggcg 360 tccgcgaaag tccattgcng ggggaagaag acac 394 83 487 DNA Mycobacterium tuberculosis 83 gaaagtgccc caaggtgttg gtgaaactcg ctggacggtc cccaggatgt tggcagcaca 60 ttcaccggac atgaccggag caagaccgga catcctccca taccgtcgtc gccgtgtaca 120 tccgtagccc gtcctggcag gtgctgggtt gaacaaaatc agcccaacac ctgccacgac 180 gaagaagcgg gttgcgctgg catgtcttgt cggctcggcg atcgaattct acgaattcct 240 tatctacggg accgctgcgg cgctggtgtt tcccaccgtg ttcttcccac acctggatcc 300 cacggtggcc gccgtggcct ccaaggggac atttgctgtg gcgttcctat cccggccgtt 360 cggcgcggcc gtctttggat actttggaga ccgcctcggc cgccagaaga ccctggtcgc 420 cacactgttg atcatgggcc tggcaaccgt gactgttggg ctggttccac gacagtggcc 480 atcgcgc 487 84 418 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 84 atattcaagc tttgtcacac caagtgttcc gaccaancgc tccatccggc gagtggatac 60 tcccagcagg tagcaggtcg ccaccacgct ggtcagtgcg cgttcatctc gcttgcggcg 120 ctgcagcagc cagtccggga aatagctgcc ctggcgcagc ttggggatcg cgacgtcgat 180 ggttgcggca cgggtgtcga aatcacggtg gcggtagccg ttgcgctgat tggaccgctc 240 atcgctgcgt tcgcggtagc ccnccccgca cagggcgtcg gcttcagccc ccatccaagg 300 cggcgatgaa cgtcgagagc agcccgcgca gcaaatccgg gctcgcctgt gcgagttggt 360 cagccagaag ctgctcggtg tcataagatg agaagaggtc agtgcgtcct ttccttcg 418 85 399 DNA Mycobacterium tuberculosis 85 caggcatgca agctttttga gcgtctcgcg gggcagcttc gccggcaatt ctactagcga 60 gaagtctggc ccgatacgga tctgaccgaa gtcgctgcgg tgcagcccac cctcattggc 120 gatggcgccg acgatggcgc ctggaccgat cttgtgccgc ttgccgacgg cgacgcggta 180 ggtggtcaag tccggtctac gcttgggcct ttgcggacgg tcccgacgct ggtcgcggtt 240 gcgccgccaa agcggcgggt cgggtgccat catgaatgcc tcaccgccgc cgcactgcac 300 ggccagtgcc ccggcgatgt cagccatcgg gacatcatgc tcgcgttcat actcctcgac 360 cagtccgcgg aacagctcca ttcccggacc gcccaacgc 399 86 474 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 86 atactcaagc ttttggctgg gtcgccttcc aattcagcgt gcaccgctat gggttgcagc 60 agcggctggc nccgcacacc ccactggccc gggtgttttc gccccgaacc cggatcatgg 120 tgagcgaaaa ggagattcnc ctgttcgatg ctgggattcg ccaccgcgag gccatcgacc 180 gattactcgc caccggggtg cgagaggtgc cgcagtcccg ctccgtcgac gtctccgacg 240 atccatccgg cttccgccgt cgggtggcgg tagccgtcga tgaaatcgct gccggccgct 300 accacaaggt gattctgtcc cgttgtgtcc aagtgccttt cgcgatcgac tttccgttga 360 cctaccggct ggggcgtcgg cacaacaccc cggtgaggtc gtttttgttg cagttgggcg 420 gaatccgtgc tctgggttac agccccgaac tcgtcacggc ggtgcgccgc cgac 474 87 383 DNA Mycobacterium tuberculosis 87 caggcatgca agcttcaacc tattgacgca ttgtgcgaac tgacggcgcc cgcgcatggc 60 caatccggaa gaccatcatt ggccagtggc cgggcgctaa caggttccag ccccccacca 120 gtgccgctcg aacatgcggt gcaacccatt cgcaggccgg cagggaaagc accgcggaag 180 ccgcaaaggg ctgcagttcc gcgcccaata gtgtcgtccg caaccagatg cgctcgaaaa 240 ccgccgccgg cagtcagcgc acccgacgcg aggtcgagag acgtcgtcag cgcgcccaca 300 tggggtgcca atcggcacgg caggtaggcc gcgcgcaacc ccaacgcgtg gtgcatgcca 360 cggtccgcag gaggccacca ccc 383 88 455 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 88 atactcaagc ttcccggccg caggtgacgg cgcggcctag cgccacttga tgccgcaccc 60 gatcgacggn cgttggtcgg ggttgactgg ccgcccggcg agcagggcgt caaccgcggc 120 ccggacgtcg gcggccgtca ccggtcggcc attgcccggg cgggagtcgt cgagctgacc 180 acggtagaca agtcggcgct ggccgtcgaa gacaaacgtg tcgggtgtgc aggccgcgga 240 gaaggcgcng gcgacgtctc gggtttcgtc gtagagatac gggaacgtcc agccgtggcg 300 gcgggcctcg gcgaccatct gatcgggccc gtcctgcggg taggtgacca cgtccttact 360 ggagataccg accatcggga ccctttgatc ggcgaggtcc cggccgaccg tggccaatcc 420 ggcggcgacg tgtcgcccgt accggccagt ggttc 455 89 429 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 89 caggcatgca agctttanca ncatcaaccc cgccccgcac cagcaccgac acgatgtcga 60 tgccatcgag gtgaatgtcg aactggcnca aaccatctgg cgaccgcgac caccggcaac 120 atgggtaccg gcgatttccg gtgccaatgc cgacccgacg ggccgctctc accgcaggtg 180 acctcgatca ccgagaccag ccggccgtta tactcacgca cccctaccgt gtcacgccca 240 aaacggcgct ggtggtcgat tgccggagtg caccccgcac ccagtgtcgt gcccggatcc 300 gccgaccaat cccgcaccca cgtcgccaaa cccgaaatca ccgtgatgcc gtggtaactg 360 accaccgaca gtaacgtcac tacggccgcc acgccgacgc cgaaccacca cgcacatgat 420 gatcggctg 429 90 321 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 90 atattcaacc ttgcacacat tgacgatacc ttggtcacga gaccccaaaa gctggcctcc 60 accgcgcgcc ggggaccacg gtcatacctt ganncngctt tcgatcgttg atgctgcgtc 120 ttggtccgcg gaaaccgcag gctggcatat gcacgtgggc gcactggcga tctgcgatcc 180 ccaccgattc gcccgaatac agctttcagc ggctccccaa gttgatcatc gaccggctgc 240 cggatatccc gcacttgcgg tggcgggtca ccggcgcccc gctcggactg gaccggccgt 300 ggttcgtcga ggaccacgaa c 321 91 134 DNA Mycobacterium tuberculosis 91 caggcatgca agcttcatgc ccgcggcatg atagccacat gcacgcaatc gaactcagcg 60 aaaccggcgg gccaggcgtc ttacgccacc tcaccagcgc gcaacctcaa cccggccacg 120 gagacctcct gatc 134 92 513 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 92 atactcaagc ttgattttga tcatcatgat gatcatcacc cgaattgtgg tagccgcagt 60 ggttatcgtg ggtaccgtcg tgctttccat gggcgcctct ttcgggcttt ccgtattggt 120 ctggcaggac attctgggta tcgagttgta ctggatggtg ttggcgatgt cggtgatcct 180 gctcntggcg gtgggatccg actacaatct gctgctgatt tcccggttga aagaggaaat 240 tggggccgga ttgaacaccg gaattatccg tgccatggct ggtaccgggg gagtggtgac 300 ggctgccggc atggtgttcg ccgttaccat gtcgttgttt gtgttcagcg atttgcgaat 360 tattggtcag atcggtacca ccatcggcct gggcttgctg ttcgacaccc tcgtcgtgcc 420 tcgttcatga aaccgtccat tgctgccctg ctgggacctg gttctggtgg ccgctacggg 480 tgcgcccgcg cccggcagtc aaatcttccg ccg 513 93 345 DNA Mycobacterium tuberculosis 93 caggcatgca agcttggcgt gccgttccaa cccgaattgg ctttcggcgc catcggtgag 60 gacggcgtgc gggtgctcaa cgacgacgtc gtccgcggga cacacctcga tgctgccgcc 120 atggacgcgg tcgaacgcaa gcagctgatc gagctacaac gccgcgcgga acgcttccgc 180 cgcgggcgtg accgcatccc gttgaccggg cggatcgcgg tgatcgtcga tgacggcatc 240 gccaccggag cgacggccaa ggcggcgtgc caggtcgccc gggcgcacgg tgcggacaac 300 gtggtgctgg cggtccccat cggcccagac gacatcgtgg cgaga 345 94 302 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 94 atactcaagc ttttacggtg atcgcgcatc acctggttca tgaactggaa gcagcgcagc 60 gcttcctttt cggccgcaac atgagccagc ctctcgtcgg cggtcgggtg caggtgctcg 120 ggcagctcgg ccgcgacagc cgcctgaccc tgaaaccagc ttccatatcc cgcgacgaac 180 gacgccagtc cgctacgtaa cccctccgcg actgtccatg gacaacagcg cgttctccac 240 cgaccgggcc cgggtgtggg gtgtttcggc gaccggcagc cangtggtcc acactgccga 300 ag 302 95 286 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 95 tagtcgctga ccggtgcagg tttcgacnat gtggtgccgg ttcggcggct acgtgccatc 60 gagacactgg cgcaggctat cgcacccgtt atcggctacg agcaaatcgc ggtatgcgtt 120 cttgagcatg agtcggcgac cgtcgtcatg gtcgacaccc acgacggaaa gacgcagatc 180 gccgtctanc ntgtgtgccg cggattatca ggactgacct cctggctgac cggcatgttt 240 ggtcgcgatg cctggcgccc ggccggcgtg gtcgtggtcg gctcgg 286 96 482 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 96 atactcaagc tttccgccga tacccgccat gtcgcgcaca tccagaactt ctggggggat 60 ccgctgacag cggcgggatc ccaaagtgcg gatgatcggg ccgcctacgt cgtggtgtac 120 ctcgtcggta acaacgaaac cgaagcgtat gactcggtcc acgcggtgcg gcacatggtg 180 gacaccacac cgccaccgca cggggtgaag gcctatgtca ccggtccggc agcactcaat 240 gccgaccagg ccgaggccgg agacaaaagt atcgctaagg tcaccgcgat cacgagcatg 300 gtgatcgcag caatgttgct agtgatctat cgccccgtaa ttaccgcggt tctcgtcttg 360 atcatggtcg gcatcgacct cggcgcaatc cgcggattcn tcgccttgct cgccgaccac 420 aacattttca gcctttcaac atttgcgaca acctgctcgt tctcatggcg attgcngcga 480 ac 482 97 395 DNA Mycobacterium tuberculosis 97 caggcatgca agcttggcgt gccgttccaa cccgaattgg ctttcggcgc catcggtgag 60 gacggcgtgc gggtgctcaa cgacgacgtc gtccgctgga cacacctcga tgctgccgcc 120 atggacgcgg tcgaacgcaa gcagctgatc gagctacaac gccgcgcgga acgcttccgc 180 cgcgggcgtg accgcatccc gttgaccggg cggatcgcgg tgatcgtcga tgacggcatc 240 gccaccggag cgacggccaa ggcggcgtgc caggtcgccc gggcgcacgg tgcggacaag 300 gtggtgctgg cggtcccgat cggcccagac gacatcgtgg cgagattcgc cgggtacgcc 360 gatgaagtgg tgttgtttgg cgacccggcg ttgtt 395 98 439 DNA Mycobacterium tuberculosis 98 atactcaagc tttggcattg tgcacatttt ccacccgtgc tctattaatg ctgagccgct 60 aattgtgacc ccagtcggga aacacgcgga gcaccaaatt caccgcagcg gccggggcgg 120 ttcaactcac catggatcgc tctcgtcgtc tggtgctgga caatcgtcgc tgtagcgcgt 180 cgcgaacacc tcagcttctg ctgccgcggc ttcttccggc gatggtaacc cccaggtttc 240 gcccacggtc ttacgtagca gtgcgacgcg gtgttcatct gcatcgacct gttgactcat 300 cctgtcaagg atgaaggcgt actgggccga ctgcgccttc tgccgcgcca ggtcggcaat 360 caccaggatc tcagaaacga gctgcgactc actcttccag gccaccctgg ccgaaagctc 420 gacatggtca atccggccg 439 99 348 DNA Mycobacterium tuberculosis 99 caggcatgca agcttgcggg ccggagtggt ttcgacggcc gctcgcttct cggcatcggt 60 ttgggctgtc accagcagtt ggtagttctt cacgtactgt tgttcgagcg tcgagccgcc 120 gcgcgtgtcg aggtcgccgg acgcgtatcc cgccaggccg gtcagggtgc ccttccagtc 180 cacgccgctg tggtcggcga accgcttatc ttcaatcgag acgatcgcca gcttcatcgt 240 gttggcgatc ttgtccgagg gcacctcgaa ccggcgctgc gagtacagcc acgcgatcgt 300 gttgcccttc gcgtcgacca tcgtcgatac cgcaggcact tgcccctc 348 100 436 DNA Mycobacterium tuberculosis 100 atactcaagc ttcccggcgg ccagtaccga aagcgcgaac agctcgcggc agcccacgac 60 gtgctgcgtc ggattgccgg cggcgaaatc aattccaggc agctcccgga caatgcggct 120 ctgctggccc gcaacgaagg actcgaggtc accccggtgc ccggggtcgt ggtgcacctg 180 ccgatcgcac aggttggccc acaaccggcc gcttgatgcc cggtcggcaa gcccggcagt 240 tgccaaaccc agcgtgatca ggctcggctc gcgagttcgg cgaagaagtg gctcgcctga 300 tcacctacca tcggccagga tctgcgtgtc atcacaacgc tcgccaagga ggttgttgtg 360 gtgctatcga cggcctttag ccagatgttc ggaatcgact atccgatagt gtccgcgcca 420 atggacttga tcgccg 436 101 445 DNA Mycobacterium tuberculosis 101 agcttcggtg tagccgatca ccggaagccg catgatcagc cacgtttcgc gccgcccggc 60 atacggcggc gtaccgatct ccgcgtcata cacccgcggg taatcgccga cggtgccggt 120 tcgcgagccg aaggtgacga cgctgattga atcgagttcc aggtccagcg ggtggcgcag 180 caacggcgcg agctcaacga cgtcaatcac gttgtcgctt tctacggtca ccgacccggt 240 gaccgtagtc gcccggtgcg ctcggccgag aagttgcacc gccaccaccg cgacaccgtc 300 ttgcacgcgg acgccacccc cggatcggtt gttggccaag gtaattgggt cattccattt 360 gacgggacgc cgaccccgca gccccagtac cgcccacgac cacgccggct gacccaccac 420 tgtacgaaca ccaaggcgac gccga 445 102 261 DNA Mycobacterium tuberculosis 102 atactcaagc ttcggtggct tcgcccgccc tgccgggtgg acttcatgac aacgcggggg 60 cgattacccc cgctaccgcc agcagcatga cggcggtacc taacaccgcc cggatgcctc 120 gcacgtgcct cgatgtgctc acggaatcgc cccggcaccg cgatctcgag gatcaccagc 180 gttacccccg gcagcgcgac accgacaatt ccgtacaccg ccacgccgat ccggccctgg 240 gccagctgat tggagctggc g 261 103 244 DNA Mycobacterium tuberculosis 103 caggcatgca agcttccaca tgtacggatc cacgaacatc ccgttgaact gacaggtgcg 60 gcccggctcg atcaggccgg ccacttgttc tacgcggtta ccgaagatct cttcggtgac 120 ctgcccgccg ccggccagct cggcccagtg cccggcgttg gccgccgcgg cgacgatctt 180 ggcgtccacg gtggtccggg tcttgcccgc tagcacgatc cgcgagtcgg ccggtcaccc 240 gggt 244 104 376 DNA Mycobacterium tuberculosis 104 atactcaagc tttccaagtc ccaagtgtcg atcatggcca aagagctcga caaagccgta 60 gaggcgtttc ggacccgccc gctcgatgcc ggcccgtata ccttcctcgc cgccgacgcc 120 ctggtgctca aggtgcgcga ggcaggccgc gtcgtcgggg tgcacacctt gatcgccacc 180 ggcgtcaacg ccgagggcta ccgaaagatc ctgggcatcc aggtcacctc cgccgaagac 240 ggggccggct ggctggcgtt cttccgcgac ctggtcgccc gcggcctgtc cggggtcgcg 300 ctggtcacca gcgacgccca cgccggcctg gtggccgcga tcggggccac cctgcccgca 360 gcggcctggc agcgct 376 105 284 DNA Mycobacterium tuberculosis 105 caggcatgca agcttcacac gtaggcgccg tcgataaatg actccgccgc gcttcgcaca 60 tcctcgtagc gatccttggc gagcaggtca accgggcgct gcccgtcgag gagccggttt 120 ttggcgtgca gccactggcc gacacctcgg ggggtaagcg aatccgagag caggaggacg 180 aggtcacgaa gctgcgccag ccggtcgtac cgctcagggc ggatgtcgcc ggtccgccac 240 ccgcgtaccg cccgatcgga cacctgtatg accgcggcga cgtc 284 106 140 DNA Mycobacterium tuberculosis 106 cgcggcggcg cattaccccc gctaccgtca gcagcttgac ggcggtagcg aacaccgccg 60 gatgcagcgc aggtgcgtct atgtgcacac ggaatcgccc cggcaccgcg atctcgagga 120 tcaccagtgc ccgccccctg 140 107 491 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 107 gggatcgagg aacagcgcgt tgaactgata ggtgcggccc ggctcgagca ggccggccat 60 ttgttcgatg cggttaccga agatctcttc ggtgacctgc ccgccgccgg ccagctcggc 120 ccagtgcccg gcgttggccg ccgcggcgac gatcttggcg tccacggtgg tcggggtcat 180 gcccgcgagc aggatcggcg agcggccggt cagccgggtg aacttcgtcg agagcttgac 240 cctgccgtcg gggaggcgaa ccacggtcgg tgcgtatctc gaccaggccc gggcaacctc 300 gggggtggcg ccgacggtga acaggttgcg ctggccaccg cgggtagccg ccggcactat 360 gccgatgccc aggccgcgga tcaccggtgc ggtcagtcgg gtcaggatgt cgcccggccc 420 caggtcgaag atccagcggg cgccggccgc gtggacacng gtgatctcgt ccaccatcga 480 ctttctgatc a 491 108 364 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 108 taactcaagg cttgcgttga ggccccaggc ccatcgacgg tttggcggcc ttaaatgcac 60 tgaggtcgtc aattgacccc acagcggaaa tgccgactat tcgcaggcct ccttcgcctt 120 ggctgccgga gaggggctcc gcgggaaccg catgcaggta tatgacctcg gtttctcggg 180 tgctaccgcg tgccttgtcg aggatgaact cggcgttgga attgtccagc cggcccaatt 240 catcgagcgc agattcgtac acatggccgg cggcgacata cgcttcaccg tggatctgct 300 ccacacggac cgccctgtcg ggatcctgct cacgggtaaa ggaacttacn tggcnctcgg 360 tgcc 364 109 453 DNA Mycobacterium tuberculosis 109 ccttctgcgc cacccacacc gtcaacgccc gcgaagtcga cgtcgtccag gccatcggcg 60 gcctcacgga tggattcggc gcggacgtgg tgatcgacgc cgtcggccga ccggaaacct 120 accagcaggc cttctacgcc cgcgatctcg ccggaaccgt tgtgctggtg ggtgtgccga 180 cgcccgacat gcgcctggac atgccgctgg tcgacttctt ctctcacggc ggtgcgctga 240 agtcgtcgtg gtacggcgat tgcctgcccg aaagcgactt ccccacgctg atcgaccttg 300 acctgcatgg ccggctgccg ctgcagcggt tcgtttccga acgcatcggg ctcgaagacg 360 tcgaggaggc gttccacaag atgcatggcg gcaaggtatt gcgttcggtg gtgatgttgt 420 gatggccgcc atcgagcgcg tcatcaccca cgg 453 110 329 DNA Mycobacterium tuberculosis 110 atactcaagc ttgattttga tcatcatgat gatcatcacc cgaagtgtgg tagccgcagt 60 ggttatcgtg ggtaccgtcg tgctttccat gggcgcctct ttcgggcttt ccgtattggt 120 ctggcaggac attctgggta tcgagttgta ctggatggtg ttggcgatgt cggtgatcct 180 gctcctggcg gtgggatccg actacaatct gctgctgatt tcccggttga aaaaagaaat 240 tggggccgga ttgaacaccg gaattatccg tgccatggct ggtaccgggg gagtggttac 300 cgctgccggc atggtgttcg ccgttacca 329 111 438 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 111 attgnctttc ggcgccatcg gtgaggacgg cgtgcgggtg ctcaacgacg acgtcgtccg 60 cgggacacac ctcgatgctg ccgccatgga cgcggtcgaa cgcaagcagc tgatcgagct 120 acaacgccgc gcggaacgct tccgccgcgg gcgtgaccgc atcccgttga ccgggcggat 180 cgcggtgatc gtcgatgacg gcatcgccac cggagcgacg gccaaggcgg cgtgccaggt 240 cgcccgggcg cacggtgcgg acaaggtggt gctggcggtc ccgatcggcc cagacgacat 300 cgtggcgaga ttcgccgggt acgccgatga ggtggtgtgt ttggcgacgc cggcgttgtt 360 cttcgccgtc gggcagggtt accgcaactt cacccagacc tccgacgaag aagtggtggc 420 gttttctgga tcgtgctc 438 112 438 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 112 atactcaagc ttttcccgtc cgtcatcgcc caagcgcgtg aggccgaagc ggctggttac 60 gactccctgt ttgtgatgga ccacttctac caactgccca tgttggggac gcccgaccag 120 ccgatgctgg aggcctacac ggcccttggt gcgctggcca cggcgaccga gcggctgcaa 180 ctgggcgcgt tggtgaccgg caatacctac cgcagcccga ccctgctggc aaagatcatc 240 accacgctcg acgtggttag cgccggtcga gcgatcctcg gcattggagc cggttggttt 300 gagctggaac accgccagct cggcttcgag ttcggcactt tcagtgaccg gttcaaccgg 360 ctcgaanagg cgctacagat cctcgagcca atggtcaagg gtgagcgcca acgtttttcg 420 gcgattggta cccaccga 438 113 482 DNA Mycobacterium tuberculosis 113 cggccaccgg ggccactccg cacaatctgt acccgaccaa gatctacacc atcgaatacg 60 acggcgtcgc cgactttccg cggtacccgc tcaactttgt gtcgaccctc aacgccattg 120 ccggcaccta ctacgtgcac tccaactact tcatcctgac gccggaacaa attgacgcag 180 cggttccgct gaccaatacg gtcggtccca cgatgaccca gtactacatc attcgcacgg 240 agaacctgcc gctgctagag ccactgcgat cggtgccgat cgtggggaac ccactggcga 300 acctggttca accaaacttg aaggtgattg ttaacctggg ctacggcgac ccggcctatg 360 gttattcgac ctcgccgccc aatgttgcga ctccgttcgg gttgttccca gaggtcagcc 420 cggtcgtcat cgccgacgct ctcgtcgccg ggaccagcag ggaatcggcg atttcgccta 480 ca 482 114 388 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 114 atactcaagc ttggggtggc gctgtcggtc ggtgtgcttg gcggcgtcgg tatcaacacc 60 gcccacgaaa tggggcacaa gaaggattcg ctggagcggt ggctgtccaa aatcaccctc 120 gcccagacct gctacgggca cttctacatc gagcacaacc gtggccatca cntccgggtg 180 tccacaccgg aggacccggc gtcggcgcgg ttcggcgaaa cgttgtggga gttcctgccc 240 cgcagtgtta tcggcggctt gcgctcggcc gttcatttgg aggcccaacg gctgcgtcgg 300 ctcggcgtca gcccctggaa tcccatgacg tatctgcgca acgacgtgcn caacncgtgg 360 ctgatgtcng tggtgttgtg gggtgggc 388 115 455 DNA Mycobacterium tuberculosis 115 tcgccaccgc accgcggcga acgctcaaag gcacctactg gcaccaaggc cccacacgtc 60 accctgtgac ctcctgcgcc gaccccgccc gaggtcctgg ccgttaccac cgaacgggcg 120 agccgggagt ctggtacgca tcgaacaaag agcaaggtgc atgggcggag ttgttccgcc 180 acttcgtcga tgacggggtc gatccattcg aggtccgtcg ccgcgtcggt cgagtggcgg 240 tcacactcca ggtactcgac ctcacagacg agaggactcg atcccatcta ggtgtggacg 300 aaacagatct tctgtccgac gactacacca ccacccaggc catcgccgcc gcccgcgatg 360 ccaacttcga cgccgtactg gccccggcgg cggcgctccc cggttgtcaa acactttgcc 420 gtgttcgttc acgcactgcc caacatcgag cccga 455 116 328 DNA Mycobacterium tuberculosis 116 atgaaataag aagagcacat ccctcagtcg gttatcatca ctagcgctcg ccgcacccgt 60 gtaaccgatc atagcgagcg aactggcgag gaagcaaaga atatctgttc tgtcagatag 120 ctcttacgct cagcgcaaga agaaatatcc cccgcgggaa caactccagg tagaggtaca 180 cacgcggata gccaattcag agtaataaac tgtgacactc acaccctcat caatgatgac 240 gaactacacc ccgatatccg gtcacatgac gaagggaaag agaaggatat catctgtgac 300 aaactgccct caaatttggc ttccttaa 328 117 318 DNA Mycobacterium tuberculosis 117 atactcaagc ttgtcgaact ccttcttgaa taccggccgg ccatccacag atgcccggaa 60 gaacttccag gtacccatgg cggctggatc agggggcggc acagttggtc ttgtcctgcc 120 tcgagtggcg tcgttgtccg gcttggacgg ggctccgacg gtaccggagg gcagcgacaa 180 aacacttatg cacttgggcg acccgccgag acggtgcgac acccatcccg acggcacaag 240 ctcagccgcg gccgctcttg ttcttcgtcg gatcgacatt cacccacttc tgaccgggct 300 tgggcgaagg aagcagaa 318 118 405 DNA Mycobacterium tuberculosis 118 ggtatagtcg ctgaccggtg caggtttcga caatgtggtg ccggttcggc ggctacgtgc 60 catcgagaca ctggcgcagg ctatcgcacc cgttatcggc tacgagcaaa tcgcggtatg 120 cgttcttgag catgagtcgg cgaccgtcgt catggtcgac acccacgacg gaaagacgca 180 gatcgccgtc aagcatgtgt gccgcggatt atcaggactg acctcctggc tgaccggcat 240 gtttggtcgc gatgcctggc gcccggccgg cgtggtcgtg gtcggctcgg atagcgaggt 300 cagcgaattc tcgtggcagc tcgaaagggt cctgccggtg ccggtctttg cgcaaacgat 360 ggcgcaggtt acggtcgcgc ggggtgcggc cctggcggcg gccca 405 119 89 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 119 gacactatat natactcaag cttcaggtca atgtgcgcca agccctgacg ctggccgacc 60 aggccaccgc cgccggancc ctntctaga 89 120 354 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 120 ctgtagccac ctgttgccat ccccgtcatg cccgactctg gtcatctcgg atccgctgac 60 accccgctaa ggctgctcct ctcggtgcat tacctcaccg acggcgaacn cccccagctt 120 tacgactatc cggatgacgg cacctggttg ccggctaact tcaccgtcag cttggacggc 180 ggcgctaccg tcgatggcgc cagcggggcg atggccgggc ccggcgaccg attcgtcntc 240 ancctgtcgc gtgaacttgc cgacgtcatc gtggtcggtg tgggcaccgt gcgcattgag 300 ggctactccg gcgtccggat gggtgtcgtc aagcgcccgc accggcaggc ccga 354 121 379 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 121 atactcaagc ttcgcacgct cggcgcgcgc ggtaccgccc aggtcgccca acagatcgtc 60 gatgttcgcg tcgtccgcct cgcgcacgtg gtctgtcacc agtcaacgtt aacgccgccg 120 cacatgtcct gcggccgggc aaaaacgtga aaaacgagcg ggcgactgcn atgtcatgac 180 accgacggcc gccgatgggc ccagggtctg gcaaattcga tctgtgcggc cagtgccagc 240 agcgtcgcct cgtcatacgg ccggccgacg agttgaaccg acatgggcag gccgtcgccg 300 tcgaagtccc acggcaccac gggcgcgggc tggccggtca gattccaaaa ttgaaagtac 360 ggaaccgctg caccaccaa 379 122 393 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 122 atcgtttcga ccaggcgctc catccggcga gtggatactc ccagcaggta gcaggtcgcc 60 accacgctgg tcagtgcgcg ttcagctcgc ttgcggcgct gcagcagcca gtccgggaaa 120 tagctgccct ggcgcagctt ggggatcgcg acgtcgatgg ttgcggcacg ggtgtcgaaa 180 tcacggtggc ggtagccgtt gcgctgattg gaccgctcat cgctgcgttc gcggtagccc 240 gccccgcaca gggcgtcggc ttcagccccc atcaaggcgg cgatgaacgt cgagagcagc 300 ccgcgcagca gatccgggct cgcctgtgcg agttggtcag ccagaagctg ctcggtgtcg 360 ataagatgan aagaagtcat tgcgttattt cct 393 123 333 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 123 atactcaagc ttgggtgttg ccgatcaccg gaagccgcat gatcagccac gtttcgcgcc 60 gcccggcata cggcggcgta ccgatctccg cgtcatacac ccgcgggtaa tcgccgacgg 120 tgccggttcg cgagccgaag gtgacgacgc tgattgaatc gagttccagg tccagcgggt 180 ggcgcagcaa cggcgcgagc tcaacnacgt caatcacgtt gtcgctttct acggtcaccg 240 acccggtgac cgtagtcgcc cggtgcgctc ggccgagaag ttgcaccgcc accaccgcga 300 caacgtcttg cacgcggacg ccaccccccg gat 333 124 426 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 124 gcgcnaacag ctcgcggcag cccacgacgt gctgcgtcgg attgccggcg gcgagatcaa 60 ttccaggcag ctcccggaca atgcggctct gctggcccgc aacgaaggac tcgaggtcac 120 cccggtgccc ggggtcgtgg tgcacctgcc gatcgcacag gttggcccac aaccggccgc 180 ttgatgcccg gtcggcaagc ccggcagttg ccaaacccag cgtgatcagg ctcggctcgc 240 gagttcggcg aaaaagtggc tcgcctgatc acctaccatc ggccaggatc tgcgtgtcat 300 cacgacgctc gccaaggagg ttgttgtggt gctatcgacg gcctttagcc agatgttcgg 360 aatcgactat ccgatagtgt ccgcgccaat ggacttgatc gccggcggtg agctggctgc 420 cgcngt 426 125 336 DNA Mycobacterium tuberculosis 125 atactcaagc tttctccgat acccgccatg tcgcgcacat ccaggacttc tggggggatc 60 cgctgacagc ggcgggatcc caaagtgcgg atgatcgggc cgcctacgtc gtggtgtacc 120 tcgtcggtaa caacgaaacc gaagcgtatg actcggtcca cgcggtgcgg cacatggtgg 180 acaccacacc gccaccgcac ggggtgaagg cctatgtcac cggtccggca gcactcaatg 240 ccgaccaggc cgaggccgga aacaaaagta tcgctaaggt caccgcgatc acgaacatgg 300 tgatcgcagc aatgttgcta gtgatctatc gctccg 336 126 347 DNA Mycobacterium tuberculosis 126 ccatgagcac cgccagccga gcacgaggcc aaactccgcc gacgcaggcc ggttggactt 60 gtcgtgctgg acaaggggtt tagccgccga agcagtgacg tacatcggcg aagagcagtt 120 cgcctgtcga ccgacggcgc aaaccgtgag gctagggaag cgaggagcac atggccgccg 180 acccgcaatg tacacgctgc aagcaaacca tcgaacccgg atggctatac atcaccgccc 240 atcgccgcgg tcaagccggg atcgtcgatg acggcgcagt actgattcac gtgcccggtg 300 aatgccgcac cccggggagc actttccgcc aaaactaacc cggttgg 347 127 315 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 127 cgggtgtcat tggccaccgg cggcggctgt ccgggaaatg gcgggtcccc ggtggttttg 60 ctgaggagtg ctgaaccgta gtcgaagtgg gcggcgtcag actccaccca gccagcaggc 120 agcgcgaanc tgaatcctcc aaccgggttg tcnatccgga caggttgggg tgcgtttggg 180 gcaatnacag gtggcggcgg tgcgttcggg tcggccggcg gaggtgctgc nttgggatcc 240 ccggctgggc attcggcntg ttggcggcgg ccggtggtgg ggggggcaac acgtgtcncc 300 ggtgcgggtg gccct 315 128 354 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 128 ccaagatcta caccatcgaa tacgacggcg tcgccgactt tccgcggtac ccgctcaact 60 ttgtgtcgac cctcaacgcc attgccggca cctactacgt gcactccaac tacttcatcc 120 tgacgccgga acaanttgac gcagcggttc cgctgaccaa tacggtcggt cccacgatga 180 cccagtacta catcattcgc acggagaacc tgccgctgct agagccactg cgatcggtgc 240 cgatcgtggg ganacccact ggcgaacctg ggttcaacca aacttgaagg tgattgttaa 300 cctgggctac ggcgacccgg cctatggtta ttcgacctcg ccgcccaaat gttg 354 129 360 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 129 agcttcccga gttcggcttt ggatcaagac cccagtccgc gggcgcgatc cggcngctcg 60 gtgactacat caagccacaa atcgacggct ttcggggtgc cgataccgat gacgtggcgg 120 atgtcgagtg ttgagttctc ggcggggcgg atgctcacct ggcgatcacc tgcctctcgt 180 tgacgatcga tcgtctatgc cgccgtctct gcgggaacag gccnccagta catcgccaca 240 gacgggatcc acccgcattt cggctacggt tgctcgtttc ggtgttcgga ctagtcggtc 300 ctggtgacgt gccggtgatg cggaccggtc ctagcactga ccaatggcca aaatgcgggc 360 130 483 DNA Mycobacterium tuberculosis 130 cggggggcct cttaatagtg taggaaagaa gctctacata ttcaggagga ttcaccatgg 60 ctcgtgcggt cgggatcgac ctcgggacca ccaactccgt cgtctcggtt ctggaaggtg 120 gcgacccggt cgtcgtcgcc aactccgagg gctccaggac caccccgtca attgtcgcgt 180 tcgcccgcaa cggtgaggtg ctggtctgcc agcccgccaa gaaccaggca gtgaccaacg 240 tcgatcgcac cgtgcgctcg gtcaagcgac acatgggcag cgactggtcc atagagattg 300 acggcaagaa atacaccgcg ccggagatca gcgcccgcat tctgatgaag ctgaagcgcg 360 acgccgaggc ctacctcggt gaggacatta ccgacgcggt tatcacgacg cccgcctact 420 tcaatgacgc ccagcgtcag gccaccaagg acccggccag atcgccggtc tcacgtgctg 480 cgg 483 131 423 DNA Mycobacterium tuberculosis 131 atactcaagc ttcataacag gcctgttgtg ggcgcacccg gctcgccgag ttctgcacgc 60 accgcctcaa gtgcggcccg caccgccggc atctcccggt cacgcagggc cgcggcccgc 120 gccgcagcga cggcgtgttc gcgcagttcg ccgtcaatga tgctgacctg atcggccacc 180 cgggcgttct cggcgtcttc gcgttcacta atcgcggtgc tcagcagcgt ctcgacagcc 240 accacccgag tggcgaccag ctgctccacc acggaccgca gcgatgccgt cacctcaccc 300 gtccagcggt ccaccacgac acggtcgtgc accagcgcgc gggcattcac cacccaggcg 360 gtcaccgcca ggccgatcgc cacacccgcc accatccccg atgcagccag gccgggagta 420 aga 423 132 338 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 132 ctggtgctgg acggagccta gtacaacttc ctctccaatg ctcttgcccc gatcgcggcg 60 accaggatga cccaggacat cctgccgccc gaagtactgg aaaagctcac acccgagttc 120 gtcgcaccgg tggtggccta cctgtgcacc gaggagtgtg ccgacaaccc atcggtgtac 180 gtcgtcagtg gtggttaggt gcagcgagtt gcgctgtttg gcaacgacgg cgccaacttc 240 gacaaaccgc cgtcngtaca agatgttgcg gcgcggtggg ccgagatcnc cgatctgtcc 300 ggtgcgaaaa ttgctggatt caagttgtag aactaaat 338 133 173 DNA Mycobacterium tuberculosis 133 atactcaagc ttttccggcg tcgtccacct gacccaaaaa gcgcaggtgc gccgccaaac 60 ggcccgcctg gccgcgcaac tggtcggcgt cgccgtggcc gacaatcagt agctggacat 120 ccggaaaccg ctgcaccacc ttcggcagcg cgtcaagcaa aaacggccat tcc 173 134 255 DNA Mycobacterium tuberculosis 134 tttcagatct catttttatg acatgactgg agatctgtct agattgcagc tcctgtgagc 60 gtgggtaccg gattcaagcc ggtcggtcac gccgcggtgg taccggcttt gcggcagtgc 120 tcggcctcga gttcggcgat cgcgcgcgaa gtgcgtttcg cgcaccaaga tcgcggccta 180 atggccggcg atgaccgcga tgaccagcgc gatccaggaa aaaccgttcc aaccagtgct 240 gggcggccat ccccg 255 135 285 DNA Mycobacterium tuberculosis 135 atactcaagc ttcccgacca caagttgaac agcaccgatt tcggcgagca cttcgtcaac 60 ttccagggtg cccgcaccaa gtatttcgac aagtatttcc gtcgggccgc cgccgccggc 120 gcgcggcagg tggtcatcct ggcggcgggg ctggactccc gcgcgtaccg gctgccttgg 180 cccgacggga ccacggtttt tgagctggac cgcccgcagg tccttgattt caagcgcgag 240 gtgctcgcca gccacggtgc ccaaccgcgc gccctgcgcc cgcga 285 136 494 DNA Mycobacterium tuberculosis 136 gtgtgctgtc aattcagagc tgagcctgat gcactcaact tactgagcat gctaacgctg 60 gtcgtgcggg tcttgttccc gcgtgtcggc agggcacacg ctcggggcgt agctgggaga 120 ggccccggtc aagcccggag agcagtgctc agtccgccag cttgaccgac tttcgatgag 180 aacgcgcttc tcgccgtatt gaactggcgt gctgacggtc gctgagcagc gctcgccgag 240 tgcggccgct gattctttca tcgagccagg aggcgcattc gtgttcggcc gcctgcgggt 300 cggccccatc gtcgacgcga tccgtcaccc actcctcgat caggtctgcc tcatcgaacg 360 ggccaacggt gctgtcggag tatgtgtgcg tgggcacggc gagccgggtg ctgtggtaca 420 cccaccgttg catgaccaag ttgacgcctg actggctgag caccgcgatc cgctcacagg 480 tcggaacgtt ggtg 494 137 357 DNA Mycobacterium tuberculosis 137 atactcaagc ttttggtcta gccggccgag cccgatacag gtgtcattgg ccaccggcgg 60 cggctgtccg ggaaatggcg ggtccccggt ggttttgctg aggagtgctg aaccgtatgc 120 gaagtgggcg gcgtcagact ccacccagcc agcaggcagc gcgaaactga atcctccaac 180 cgggttgtcg atccggacag gttggggtgc gtttggggca atgacaggtg gcggcggtgc 240 gtccgggtcg gccggcggaa gtgctgcgtt gggatcgccc ggctgggcat tctgcgtgtt 300 ggcggcggcc ggtggtgggg gggcaacagg tgtctccggt gcgggtggcg ctgcacc 357 138 458 DNA Mycobacterium tuberculosis 138 ggggccactc cgcacaatct gtacccgacc aagatctaca ccatcgaata cgacggcgtc 60 gccgactttc cgcggtaccc gctcaacttt gtgtcgaccc tcaacgccat tgccggcacc 120 tactacgtgc actccaacta cttcatcctg acgccggaac aaattgacgc agcggttccg 180 ctgaccaata cggtcggtcc cacgatgacc cagtactaca tcattcgcac ggagaacctg 240 ccgctgctag agccactgcg atcggtgccg atcgtgggga acccactggc gaacctggtt 300 caaccaaact tgaaggtgat tgttaacctg ggctacggcg acccggccta tggttattcg 360 acctcgccgc ccaatgttgc gactccgttc gggttgttcc cagaggtcag cccggtcgtc 420 atcgccgacg ctctcgtcgc cgggacccag cacggaat 458 139 595 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 139 ttctntcttc ccnnattcgt nnntctcnta ctaccngggc cncaaaacac cttggcnaac 60 gctcaaaggc gntacnggca ccaaggcccc acacgtcacc ctgtgacctc ctgcgccgac 120 cccgcccgag gtcctggccg ttaccactga acgggcgagc cgggagtctg gtacgcatcg 180 aacaaagagc aaggtgcatg ggcggagttg ttccgccnct ttttttatga cggggtcgat 240 ccattcgagg tccgtcgccg cgtcggtcga gtggcggtca cactccaggt actcgacctc 300 ncagacgaga ggactcgatc ccatctangt gtggacnaaa cagatcttct gtccgacgac 360 tacacaccac ccaggccatc gccgccgccc gcgatgccaa cttcnacncc gtnctggccc 420 cggcggcggc gctccccggt tgtcaaacac ctgccgtgtt cgttcacnca ctgcccaaca 480 tcnagcccga ncnatccnag gtccgtccaa cgcctccgcg gctcnccaac ctnctcccnc 540 tgatcntccg caccaaacac atgcccgact ccntgcnccn attgcttgna tccct 595 140 434 DNA Mycobacterium tuberculosis 140 ccgctatcgg tcggtgtgct tggcggcgtc ggtatcaaca ccgcccacga aatggggcac 60 aagaaggatt cgctggagcg gtggctgtcc aagatcaccc tcgcccagac ctgctacggg 120 cacttctaca tcgagcacaa ccgtggccat cacgtccggg tgtccacacc ggaggacccg 180 gcgtcggcgc ggttcggcga gacgttgtgg gagttcctgc cccgcagtgt tatcggcggc 240 ttgcgctcgg ccgttcattt ggaggcccaa cggctgcgtc ggctcggcgt cagcccctgg 300 aatcccatga cgtatctgcg caacgacgtg ctcaacgcgt ggctgatgtc ggtggtgttg 360 tggggtgggc tgatcgcggt cttcggcccg gcgctgatcc cgttcgtcat catccaggca 420 gtcttcggct tcag 434 141 321 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 141 atactcatgc ttgccgaagt tccgatgggt cgcgccggcg ancccagcga agtcgctagc 60 gtggccgtgt tcttggcttc ggatctatcc tcgtacatga ccggcaccgt gttggacgtg 120 actggcggcc ggttcatatg acaccgagat cattgccacg gtacggcaat tcgtcaagaa 180 ggaaatcttt cccaatgcac cggccctcga acgtggcaac agctacccgc aagaaatcgt 240 cgatcggctg ggtgttattg gcttgctcgg tcgccggctg caagggtatc gacaccaccg 300 agttcattct ccgggcgtgc c 321 142 348 DNA Mycobacterium tuberculosis 142 ggcgtcaacg gtgtcggcac cggcgtcctg cagttggtag gcctgcagtt tgtgcatcag 60 gccgatgccg cggccctcgt ggccacgcat gtacagcacc acgccgcgcc cctcacgggc 120 gaccatcgcc agcgcggcgt ccagctgagg cccgcaatcg cagcggcgtg acccaaacac 180 atcgccggtc aagcactccg aatgcacccg gaccagcacg tcgtcaccgt cggcgttggg 240 cccggcgatc tcgccgcgga ccagcgcgac atgttccacg tcctcgtaga tgctggtgta 300 gccgatggcg cgaatctccc atgacgagtc ggaatccgcg cctcggcg 348 143 339 DNA Mycobacterium tuberculosis 143 atactcaagc ttcggcctcg ctgcaggagt gggagccgca gggctggaaa tccgaaaaac 60 gagccggtga tcgcactgtc gccgatcggg gccgcacctg gttggtgtta ccgatgaatc 120 cgcacccaaa atgtggctgc ggtggcgttt cttgactcct tggcgtcgac tcttgtggca 180 gccaccgagc ggttggtcca ggatctggat gggcaaagtt gtgcggcccg gccggtgacg 240 gccgatgagc tgaccgaggt cgacagcgcc gtgttggctg acttggaacc gacatggatt 300 cgccccggtt ggcgtcacct caagcatttc aatggttat 339 144 269 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 144 atgcgtcacc ccgatgcgcc cagatcgggg cttcgcaaat aaagcacgaa caggcgggca 60 aaacgtctat ctcggagccg gaagggcaat cagccgaccg tcgacgaacg acaccggcga 120 taaccactta ggcgttgaac ggccggccca aacattacgc ctccgttgat aaggctttcg 180 gtctcttccc cggtcatccc aagcaccttg cggcaaattt gaacgctttc ctgtccgggc 240 accggccccg ggctttgggg tccntccga 269 145 285 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 145 atactcaagc ttcaatcgcg ccgccacaat ccaaatatgc gtctagcgtc tcgatgagcg 60 tcggtccggc atcggctagg ggccgcatca cgtcggtatg cagggccacg atcgcccaag 120 gcgtcgccca tcaagggcgc gttcgggcaa aaattcccct atccagcacg ggccgcggcg 180 ctccgcncca gccggcgacg gcgttcatcc cggagatcgc ctcgctagcg ctgcggtgcg 240 ccgcggtcag catgggcgcc gtggggccga tgaccaccgg ggcgt 285 146 75 DNA Mycobacterium tuberculosis 146 ttcggcgggt ctgtagattg cggtcggcca ccccacaggc actcatgaac cgcagcccac 60 gatcgatctc ggtgg 75 147 164 DNA Mycobacterium tuberculosis 147 gcgcaccatc gccagtaggt gcccgtggtc gggcgcgtcg agccacccga gcggaaacgc 60 gagtccgaac agcaacagca ggacgggcgc aaccagggcg gtgaccatgc ccccggcgct 120 gaacatcaac cacaggaagg gctccgccga gcgtccgcgc gacc 164 148 228 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 148 catcgtcgaa cttcggtccg ggttgntagn accgcagcac caaacgcacc caccgacccc 60 cacgcttcac gccaaccctt tagttcattg gcgtgaacag cagcgtagcc ggttgccccg 120 atatatgtgg aaaaatcgtt cggacgtaca aaaaaagttc ctgacgctgg cgtcaactcg 180 aaactgcctc ggaagtcaat gatgatccat cagtcaatat taaagtcg 228 149 238 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 149 atactcaagc ttgtctgctg cctcagcgta tgcatccaac agcgcatcgc gatcaacgat 60 caggcgcgcc gatttcgggc cgcgggcagt ggcactggcc agatggccgt ttttttcgag 120 aaacttcaac gcctgagcgc tgcttcccat cgagagaccg gtggcctcta caaccgatgc 180 gacagttgga ccggcgatgt tcgccagcag cgcttcacat acggcaagtn tggcgcgg 238 150 162 DNA Mycobacterium tuberculosis 150 ttgtccaggc ggggaatcgg gcagggagac gacaccttcg ttcggttcga tcgtcgcgaa 60 cgggtagttg gccgcgacca cgttgtttcg ggtcagcgcg ttgaaaagtg tcgacttgcc 120 gacgttgggc aggcccacga tccccaggct caagctcaca ga 162 151 377 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 151 atactcatgc ttggcgcctg ggtggcagcc cacctgccca ccacacggac cgcggtgcgg 60 acgcggctga cgcgcctggt ggtcagcatc gtggccggtc tgctgttgta tgccaacttc 120 ccgccgcgca actgctggtg ggcggcggtg gttgcgctcg cattgctggc ctgggtgctg 180 acccnccgcn cnacaacacc ggtgggtggg ctgggctacg gcctgctatt cggcctggtg 240 ttctacgtct cgttgttgcc gtggatcggc gagctggtgg gccccgggcc ctggttggca 300 ctggcgacga cgtncgcgct gttccccggc atcttcggtc tgttcgccgt cgtggtaccc 360 tgttgccggg ttggccc 377 152 308 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 152 cgccaattca cgatatcgtt aaccgatatc ccgagccgat agctggcggg ctcgggtggt 60 ggccagcggc gctgcgacga aaggtgtgac cgtcatgaaa cagacaccac cggcggccgt 120 cggccgtcgt cacctgctcg agatctcagc atccgcagcc ggtgtgatcg cgctttcggc 180 gtgtagtggg tcgccgcccg accccggcaa aggccggccc gacacaaccc cggaacagga 240 agtcccggtc accgcgcccg aagnacttga tgcgcgaacn cggagtgctc caaacgcatc 300 ctgctgat 308 153 377 DNA Mycobacterium tuberculosis 153 atactcaagc ttgggcactg acttcggtac cccctccgcc tttggccagc agcagccaca 60 gcgcggttcg cggaccgaac gtggacatca atagcccgga atcggtgtgt gcaagttggt 120 aaacggtgtt gatcccaagc tttgccagcc ttttcgtagt cttgggcccc acaccccaca 180 gtgcttcgac ggtacggtca cccatgatgg ccatccagtt ggcatcggtg agctgataaa 240 tgccagctgg tttcgccaac ccggtagcga tcttggcgcg ctgcttgttg tcactgatac 300 ctatcgagca agacagcccg gtttgcgaca aaatgacttt tcggatctct tcggcgactt 360 cgatggggtc gtcggga 377 154 259 DNA Mycobacterium tuberculosis 154 aaagtcctgt gccggttcgc taaacacccg gcggacactc agacggtgct ggtggtgcgg 60 catggcaccg cgggcagcaa agcgcacttc tccgggggac gacagcaagc gaccgctaga 120 caagaggggt cgtgcgcagg cagaaacgtt ggtacacagc tgctggcgtt cggcgccacc 180 gatgtttatg ccgccgaccg ggtgcgctgc caccagacga tggagccact cgccgcggaa 240 ctgaacgtga ccatacaca 259 155 372 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 155 atactcaagc ttgggttcca cgcccgcgca gccacgccgt cacctttcca cgagacctca 60 cctgccgatc cgaaatggaa tcggccgtga cggaattggc gcaccgaaca cccaacgagg 120 tggtggcttc gtcgcgaacc gtcacccgag tcgcggccac cgtgcgcacg gcgacgttct 180 acacccgcac caagatccga aagctgcaag ctcccagcac cgatcccgac gtcatcaccg 240 ctgccgcccg gcacgtcctt gacctattcg agctggatcg gcccgtccgg ttgctgggag 300 tgcggttaga actggcctag aaccggcggg cacaccgcnc ctgggcgggg cgaattcttg 360 accgcnccgg cc 372 156 290 DNA Mycobacterium tuberculosis 156 cgcggttggc gtagttggac gggtcgccct ccgaggccaa tgatgacgat gaccacgccg 60 atcacgatgg ccaccgagag ggacaacaac agaaagctga cgaatccctc cttggcggcc 120 ggggctttgt ggtcgccggt cgcgatgggc gcgaatttac ggcccgctcc cccaggccgc 180 cgcgaagcag ggtccccagc cagttggcgt aggcggaatt aacgatcagc gccaccgcga 240 taacctgcca tgcctcgggc atatcgatgt gcggccagaa caggccgaac 290 157 470 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 157 ccaacaagag catcgggaca tacggagtca actacccggc caacggtgat ttcttggccg 60 ccgctgacgg cgcgaacgac gccagcgacc acattcagca gatggccagc gcgtgccggg 120 ccacgaggtt ggtgctcggc ggctactccc agggtgcggc cgtgatcgac atcgtcaccg 180 ccgcaccact gcccggcctc gggttcacgc agccgttgcc gcccgcagcg gacgatcaca 240 tcgccgcgat cgccctgttc gggaatccct cgggccgcgc tggcgggctg atgagcgccc 300 tgacccctca attcgggtcc aagaccatca ncctctgcaa caacggcgac ccgatttgtt 360 cngacggcaa ccggtggcga gcgcacctag gctacgtgcc cgggatgacc aaccaggcgg 420 cgcgtttcgt cgcgagcagg atctaaccgc gagccgccca tagattcccg 470 158 434 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 158 taanacccgt gtaatttggg atgggcaaaa aggccaagca ccgcgtggcc acgaacgccg 60 ggagggacaa tctcgggcgg ctagggcttc tcgcgggaag gcccgaacgt acggcgtttc 120 aacacgtcgc gtcnccctcc gaccgcgaac attcggggat ggcagcaacc tggtagcncc 180 ctggccgggc gatgatctgc agcgtcgccg cgggtagtcg ccgcccgggc ggctacagtc 240 tgaaacgcga tgaccatcga tgtgtggatg cagcatccga cgcaacggtt cctacacggc 300 gatatgttcg cctcgctgcg ccggtggacc ggtgggtcta tcccggagac cgacntcccg 360 atcgaagcga ccgtctcctc gatggacgcc ggcggcgtca ccctgggttt gctcaccgcc 420 tggcgtggcc ccaa 434 159 363 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 159 gtccgcaaaa gactcagcgg ccgactttgc tcgcagctgg cggtaccgcg ccaccgattc 60 gatgccgtgg tcgcggaaga atgcctcccg aaatcgcacg gccgactcca gttcggcgag 120 catccgcgat gccagctgcg gctgcgccct gccggccacg gcacccacat gcggcagttc 180 gtccacctgg gccagcgccc cgccgccgaa gtccaaacaa tagaactgca cccggcccgc 240 atcgtgggta gcagccaacg ccatgatcag cgtccgcagc gcggttgact tgcccgtttg 300 cggtgcacct acgaccgcga cattgcctgc ggccccggac aagtcgatcg tcagcggcac 360 ccn 363 160 301 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 160 cgtggccacg aacgccggga gggacantct cgggcggcta gggcttctcg cgggaaggcc 60 cgaacgtacg gcgtttcaac acgtcgcgtc gccctccgac cgcgaacatt cggggatggc 120 agcaacctgg cagctacctg gccgggcgat gatctgcagc gtcgccgcgg gtagtcgccg 180 cccgggcggc tacagtctga aacgcgatga ccatcgatgt gtggatgcat catccgacgc 240 aacggttcct acacggcgat atgttcncct cgctgcgccg gtggaccggt gggtctatcc 300 c 301 161 436 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 161 atactcaagc tttgcggcgg gcgccgaaat gtgaacgcac caaacccgcc cgctgcgggt 60 cggcgggcca ctcgacctcg aatttcgccg ccgtgaccat ccagcccgac ggcagttggg 120 cacccggccc cccggtcgcg gcataactgt tggcgtcgcc gtcataaagc tcgaacagca 180 ccgaaaccga ctccaccacc ggccggtgcg cctcaaaatc cacgccgatc tccacatacc 240 gggaaaacgt cggtgtccca tcgggtttcg gcttgcccgc cagctgcaca ccaccggtgg 300 cctcggccac cttcgcggcc tgagcgcagc tacncatcct gacgatcatc accccgcccc 360 cggctcacgc ttggcctccg tgaccgcacg catcgcccgg ttgcgcgcac cgcgacgccc 420 gtacagccgc gcgcac 436 162 390 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 162 agcttgccgg gactgcggaa cagaagcggc ggttcctacc gcggtgtgcg gccggcgcga 60 tatcggcctt tttactaacc gaacccgatg tgggctccga tccggcgcgc atggcatcga 120 cggcgacgcc gatcgatgac ggccaggctt acgagcttga gggtgtgaag ttgtggacca 180 ccaacggtgt ggtagcggac ctgctagtgg ttatggcgcg ggtaccgcgc agtgaagggc 240 accgaggggg aatcagcgcc tttgtcgtcg aggctgattc gcccgggatc accgtggagc 300 ggcgcaacaa gttcatggga ctgcgtggca tcnaaaacgg cgtgacccgg cttcatcgcg 360 tcngggtgcc caaagacaac ttgatcggca 390 163 75 DNA Mycobacterium tuberculosis 163 ctcaagcttg gcgatgcggg ctggccaaaa ctggccgggc gggggttggc ttgttcaatc 60 aagggtgggt tgccg 75 164 110 DNA Mycobacterium tuberculosis 164 ccgaaggccc gttcccgggc gttcagcaag cgatcgtcgg ttggcccact gcgggtcgaa 60 tcttgcggcc gcgccggtcg tggaacgccc aggtcacccg gcggcgtacc 110 165 455 DNA Mycobacterium tuberculosis 165 atactcaagc ttttttctgc tcatgaaggt tagatgcctg ctgcttaagt aattcctctt 60 tatctgtaaa ggctttttga agtgcatcac ctgaccgggc aaatagttca ccggggtgag 120 aaaaaagagc aacaactgat ttaggcaatt tggcggtgtt gatacagcgg gtaataatct 180 tacgtgaaat attttccgca tcagccagcg cagaaatatt tccagcaaat tcattctgca 240 atcggcttgc ataacgctga ccacgttcat aagcacttgt tgggcgataa tcgttaccca 300 atctggataa tgcagccatc tgctcatcat ccagctcgcc aaccagaaca cgataatcac 360 tttcggtaag tgcagcagct ttacgacggc gactcccatc ggcaatttct atgacaccag 420 atactcttcg accgaacgcc ggtgtctgtt gacca 455 166 309 DNA Mycobacterium tuberculosis 166 ctcaagcttg gtgccgacat ggccgggctg gagcccgcgt atggcaaggt tccgctcaat 60 gtggttgtga tgcagcagga ctacgttcgc ctcaatcagc tcaaacgtca cccccgtggc 120 gtgctgcgca gcatgaaggt cggcgcccgc acgatgtggg cgaaggcaac aggtaaaaac 180 ctggtcggca tgggtcgagc cctcattggg ccgttgcgga tcgggttgca ccgcgccgga 240 gtgccggtcg aactcaacac cgccttcacc gatcttttcg tcaaaaatgg cgtcgtgtcc 300 ggggtatac 309 167 232 DNA Mycobacterium tuberculosis 167 ccgaagcgtg ggaaatcctg accgaatacc gcgacgtgct ggacactttg gccggcgagc 60 tgctggaaaa ggagaccctg caccgacccg agctggaaag catcttcgct gacgtctaaa 120 agcggccgcg gctcaccatg ttcgacgact tcggtggccg gatcccgtcg gacaaaccgc 180 ccatcaagac acccggggga gatcgcgatc gaaacgcggc gaaacttggg cc 232 168 455 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 168 cgactcgaca agcattcttg acagttgttt tggctcggca tggttagcca aggttctgcg 60 gtcccaccag atcatcttgg tccggtagcg ctcgtccggg tatgctgccg ccgggattct 120 cgctgctatt actccccccg aaaaacgcca ccggtccagc gcgtgggccg ccgcggtccc 180 catcacaaac tgaaccccca acaggggaca tgcttagcgg tagggcgcgc gccaaggcgg 240 cagcaatcgc atcactgcgc tgcgcgtcac tattaaccca cccggacttc acttccacga 300 ccccgaatgg cgcccggtca ttgatcatct tgcgcaccgc ggataatccg ggattgccag 360 cccattcgac taccgcatgc gagtcatcgg ctgaccgcag cggtccgatt acccgagcgc 420 cccgantaca tctcctccaa tatcaatggg cgcaa 455 169 428 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 169 gcggtntagc ttcccgtcgt accggcgacc gccagccgag aagctcgttt tcccagtgtt 60 gctggggatt ctcacgctgc tgctgagtgc gtgccagacc gcttccgctt cgggttacaa 120 cgagccgcgg ggctacgatc gtgcgacgct gaagttggtg ttctccatgg acttggggat 180 gtgcctgaac cggttcacct acgactccaa gctggcgccg tctcgtccgc aggtcgttgc 240 ttgcgatagc cgggaggccc ggatccgcaa tgacggattc catgccaacg ctccgagttg 300 catgcggatc gactacgaat tgatcaccca gaaccatcgg gcgtattact gcctgaagta 360 cctggtgcgg gtcggatact gctatccggc ggtgacgacc cccggcaagc cgccatccgt 420 gctgctgt 428 170 385 DNA Mycobacterium tuberculosis 170 ctcaagcttg ggcgtgacgg ccaccggggc cactccgcac aatctgtacc cgaccaagat 60 ctacaccatc gaatacgacg gcgtcgccga ctttccgcgg tacccgctca actttgtgtc 120 gaccctcaac gccattgccg gcacctacta cgtgcactcc aactacttca tcctgacgcc 180 ggaacaaatt gacgcagcgg ttccgctgac caatacggtc ggtcccacga tgacccagta 240 ctacatcatt cgcacggaga acctgccgct gctaaagcca ctgcgatcgg tgccgatcgt 300 ggggaaccca ctggcgaacc tggttcaacc aaacttgaag gtgattgtta acctgggcta 360 cggcgacccg gcctatggtt attcc 385 171 318 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 171 cgggtgtcat tggccaccgg cggcggctgt ccgggaaatg gcgggtcccc ggtggttttg 60 ctgaggagtg ctgaaccgta gtcgaagtgg gcggcgtcag actccaccca gccagcaggc 120 agcgcgaagc tgaatcctcc aaccgggttg tcgatccgga caggttgggg tgcgtttggg 180 gcaatgacag gtggcggcgg tgcgttcggg tcggccggcg gaggtgctgc gttgggatcg 240 cccggctggg cattcggcgt gttggcggcg gccggtggtg ggggggcaac angtgtcgcc 300 ggtgcgggtg gcgctgca 318 172 443 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 172 ncttgatatt ggcgtcaacg gtgtcggcac cggcgtcctg cagttggtag gcctgcagtt 60 tgtgcatcag gccgatgccg cggccctcgt ggccacgcat gtacagcacc acgccgcgcc 120 cctcacgggc gaccatcgcc agcgcggcgt ccagctgagg cccgcaatcg cagcggcgtg 180 acccaaacac atcgccggtc aagcactccg aatgcacccg gaccagcacg tcgtcaccgt 240 cggcgttggg cccggcgatc tcgccgcgga ccagcgcgac atgttccacg tcctcgtaga 300 tgctggtgta gccgatggcg cgaaactccc catgacgagt cggaatccgc gcctcggcga 360 cccgctcaat gtgcttctcg tgcttgcgcc gccattcgat caagtcagca atggtgatca 420 gcgccagacc gtgctcntcg gcg 443 173 420 DNA Mycobacterium tuberculosis 173 cataagggcc ggcgtacccg gtaccggccg cgggcctacc acgtgccgga actggaagcg 60 cagtaagccc tcaacgcgcc accgctttgg cccgcgcgcc cggcgtaggc gcatcggcgg 120 tggccgtggg gcggcgcact gcgacctcac cagcggcttt cgagctttgt tcgatcaacc 180 ggccagcatg gtcgaggatg cattcgagac catattcgaa attggtttca tcgggggccc 240 cgatccgatg ccccctccca gttgcgtgag caagcagcgg agtcgtcgcg ggatcgatgg 300 ccacggggtg ttcaatggcg gatggtccgc tgcccgccga ctggctcttg cgggagagcc 360 gatctagcac caccgatccg cgcacgtgga ccgaaaccgc cgagtagatg tcgaaagcgt 420 174 336 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 174 cgtccttttc cccaagatag aaaggcagga gagtgtcttc tgcatgaata tgaagatctg 60 gtacccatcc gtgatacatt gaggctgttc cctgggggtc gttaccttcc acnagcaaaa 120 cacgtagccc cttcagagcc nnatcctgag caanatgaac agaaactgag gttttgtaaa 180 cgccaccttt atgggcagca accccgatca ccggtggaaa tacgtcttca gcacgtcgca 240 atcgcgtacc aaacacatca cgcatatgat taatttgttc aattgtataa ccaacacgtt 300 gctcaacccg tcctcgaatt tccatatccg ggtgcg 336 175 264 DNA Mycobacterium tuberculosis 175 ctcaagcttc atgtccgtac ggctcgggta cgcttccgtc gcagtgtgcg agtgataaat 60 gacgaccggg acctcgtcgg catcttccat agcccgccac accttcagtt gctcaccgga 120 atccaaccgg tagaaggtcg gcgagcgctc ggcattggtc atcgggatat gccgctcggg 180 acggtcagag ccctcgggtc cggccagcac tccgcaggct tcgtcggggt ggtcgcgaca 240 cgcatgggcc accatcgcat tcac 264 176 325 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 176 ncgccgccag ccaccacgcg cgggtcgggc gccgggcccg ggccgccagg ctgctccgct 60 cggtgatggc acgccaccgc gacaccaccc ggctgcgcta cgtcgagcca taccgggcgg 120 agctacatcg gctcggccgc ccagtgttcg ggccctcttt cgaggtcgag gtcgataccg 180 atttgcgcat ccgcagccgc accctggacg acagaaccgt gccctacgan tgcttgtcgg 240 gcggggccaa agaacagctt ggcatcctgg cgcgattggc cggcgcggcg ctggtctcca 300 aagaagacgc ccttccggtg ctgat 325 177 243 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 177 cgccacgttc atgggcaaca accccgatca ccggtggaaa tacgtcttca gcacgtcgca 60 atcgcgtacc aaacacatca cgcatatgat taattcgtcc aattgtataa ccaacacgtt 120 gctcaacccg tcctcgaatt tccatatccg ggtgcggtag tcgccctgct ttctcggcat 180 ctctgatagc ctgagaagaa accccaacta aatccgctgc ttcncctatt ctccagcgcc 240 ggg 243 178 430 DNA Mycobacterium tuberculosis 178 atactcaagc ttcaaccgat tgacgcattg tgcgaactga cggcgcccgc gcatggccaa 60 tccggaagac catcattggc cagtggccgg gcgctaacag gttccagccc cccaccagtg 120 ccgctcgaac atgcggtgca acccattcgc aggccggcag ggaaagcacc gcggaagccg 180 caaagggctg cagttccgcg cccaatagtg tcgtccgcaa ccagatgcgc tcgaaaaccg 240 cgccggcagt cagcgcaccc gacgcgaggt cgagagacgt cgtcagcgcg cccacatggg 300 gtgccaatcg gcacggcagg taggccgcgc gcaacccgaa cgcgtggtgc atgcccacgg 360 tccgcaggag gcgcagcacc cgccaatgcc gaagcccacg aaacatcggg cgcatccacg 420 cttcaacctc 430 179 448 DNA Mycobacterium tuberculosis 179 agcttttggc agggtctcct tcgaattcgg cgtgcaccgc tatgggttgc agcagcggct 60 ggcgccgcac accccactgg cccgggtgtt ttcgccccga acccggatca tggtgagcga 120 aaaggagatt cgcctgttcg atgctgggat tcgccaccgc gaggccatcg accgattact 180 cgccaccggg gtgcgagagg tgccgcagtc ccgctccgtc gacgtctccg acgatccatc 240 cggcttccgc cgtcgggtgg cggtagccgt cgatgaaatc gctgccggcc gctaccacaa 300 ggtgattctg tcccgttgtg tcgaagtgcc tttcgcgatc gactttccgt tgacctaccg 360 gctggggcgt cggcacaaca ccccggtgag gtcgtttttg ttgcagttgg gcggaatccg 420 tgctctgggt tacagcccga atcgtcac 448 180 380 DNA Mycobacterium tuberculosis 180 atactcaagc tttgtcacac caactgtttc caccaggcgc tccatccggc gagtggatac 60 tcccagcagg tagcaggtcg ccaccacgct ggtcagtgcg cgttcagctc gcttgcggcg 120 ctgcagcagc cagtccggga aatagctgcc ctggcgcagc ttggggatcg cgacttctat 180 ggttgcggca cgggtgtcga aatcacggtg gcggtagccg ttgcgctgat tggaccgctc 240 atcgctgcgt tcgcggtagc ccgccccgca cagggcgtcg gcttcagccc ccatcaaggc 300 ggcgatgaac gtcgagagca gcccgcgcag cagatccggg ctcgcctgtg cgagttggtc 360 agccagaacc tgctcggtgt 380 181 532 DNA Mycobacterium tuberculosis 181 ccttaagccc cgcagggccc ggcacgcgcg gtaccgccca ggtcgcccaa cagatcgtcg 60 atgttcgcgt cgtccgcctc gcgcacgtgg tctgtcacca gtcaacgtta acgccgccgc 120 acatgtcctg cggccgggca aaaacgtgaa aaacgagcgg gcgactgcaa tgtcatgaca 180 ccgacggccg ccgatgggcc cagggtctgg cagattcgat ctgtgcggcc agtgccagca 240 gcgtcgcctc gtcatacggc cggccgacga gttgaaccga catgggcagg ccgtcgccgt 300 cgaagtccca cggcaccacg gccgcgggct ggccggtcag attccagact tgaaagtacg 360 gaacccgctg caccaccagc agcaacgtcg aaactgcacc ccggcgttgg taggcgccga 420 tgcgggacgg gccggtcgcg gcgcctggcg tcacaactac gtcgacatcg tcgaagatcg 480 actggatcgg ctgctcacac cactcggcgg ccgcaggccg ccatccgccg tc 532 182 477 DNA Mycobacterium tuberculosis 182 agctttttga gcgtcgcgcg gggcagcttc gccggcaatt ctactagcga gaagtctggc 60 ccgatacgga tctgaccgaa gtcgctgcgg tgcagcccac cctcattggc gatggcgccg 120 acgatggcgc ctggaccgat cttgtgccgc ttgccgacgg cgacgcggtg ggtggtcaag 180 tccggtctac gcttgggcct ttgcggacgg tcccgacgct ggtcgcggtt gcgccgcgaa 240 agcggcgggt cgggtgccat caggaatgcc tcaccgccgc ggcactgcac ggccagtgcc 300 gcggcgatgt cagccatcgg gacatcatgc tcgcgttcat actcctcgac cagtcggcgg 360 aacagctcga ttcccggacc gcccagcgca ttggtgatgg aatcggcgaa cttggccacc 420 cgctgggtgt tgacatcctc gacggtgggc aattgccccc ggtaacgttt gccgcct 477 183 461 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 183 cggtccgacc ctgttcgacg gctacctgaa tcaacccgat gccaccgccg cggcgttcga 60 cgccgacagc tggtaccgca ccggcgacgt cgcggtggtc gacggcagtg ggatgcaccg 120 catcgtggga cgcgagtcgg tcgacttgat caagtcgggt ggataccggg tcggcgccgg 180 tgaaattgaa acggtgctgc tcgggcatcc ggacgtggcg gaggcggcag tcgtcggggt 240 gcccgacgat gatctaggcc agcggatcgt tgcctacgta gtcggctcag cgaatgtcga 300 tgcggacggg cttatcaact ttgttgccca acaactttcg gtgcacaagc gcccgcgcga 360 ggtgcgtatc gtanatgcgc tgccgcgcaa cgccttgggg aaagtgctcc agaacattgc 420 tgtcagaagc tganctacgc gaattatcgt gttacgctgg a 461 184 440 DNA Mycobacterium tuberculosis 184 atactcaagc ttgccgaagt tccgatgggt cgcgccggcg agcccagcga agtcgctacc 60 gtggccgtgt tcttggcttc ggatctatcc tcgttcatga ccggcaccgt gttggacgtg 120 actggcggcc ggtccatatg acaccgagat cattgccacg gtacggcaat tcgtcaagaa 180 ggaaatcttt cccaatgcac cggccctcga acgtggcaac agctacccgc aagaaatcgt 240 cgatcggctg ggtgttattg gcttgctcgg tcgccggctg caagggtatc gacaccaccg 300 agttcattct cgggcgtgcc ggcgcattcg agctggcggt gcgcgctgcc cagcaccgtc 360 ataggtactt gacgatggtc cacgtcggac gagcgcctcc acgtcgctgc cgaacggtat 420 gcatggcggc tacgattctc 440 185 515 DNA Mycobacterium tuberculosis 185 cggtgtcggc accggcgtcc tgcagttggt aggcctgcag tttgtgcatc aggccgatgc 60 cgcggccctc gtggccacgc atgtacagca ccacgccgcg cccctcacgg gcgaccatcg 120 ccagcgcggc gtccagctga ggcccgcaat cgcagcggcg tgacccaaac acatcgccgg 180 tcaagcactc cgaatgcacc cggaccagca cgtcgtcacc gtcggcgttg ggcccggcga 240 tctcgccgcg gaccagcgcg acatgttcca cgtcctcgta gatgctggtg tagccgatgg 300 cgcgaaactc cccatgacga gtcggaatcc gcgcctcggc gacccgctca atgtgcttct 360 cgtgcttgcg ccgccattcg atcaagtcag caatggtgat cagcgccaga ccgtgctcat 420 cggcgaacac cgcaattcat cggtgttgcg ccatcgagcc ctcatctttt tggctgacga 480 tctcgcaaat cgcccccgcg ggttgcagcc ggcat 515 186 345 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 186 atactcaagc tttgggtgaa agccgatcac cggaagccgc atgatcagcc acgtttcgcg 60 ccgcccggca tacggcggcg taccgatctc cgcgtcatac acccgcgggt aatcgccgac 120 ggtgccggtt cgcgagccga aggtgacgac gctgattgaa tcgagttcca ggtccagcgg 180 gtggcgcagc aacggcgcga gctcaacgac gtcaatcacg ttgtcgcttt ctacggtcac 240 cgacccggtg accgtnctcg cccggtgcgc tcggccgata agttgcaccg ccaccaccgc 300 gacaccgtct tgcacgcgga cccacccccg gatccgttgt tggcc 345 187 366 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 187 agcttgctgg catccgctcc agtagcgccc cgcgcgtggc ttccagcgcc cgcagatgct 60 ccatgagccg gccggtcgag tcggcgccgg cgttcaccgc cacccgccag gagctggcgg 120 ccagcatctc cgccttcacg cattgcgcga tcacagagag aatatacgtc tcatattcgt 180 tggaggtcgt cgcaggcaat cggtcgatga cggatttgat ggcatcgagc tgtgcttcgg 240 cgtagccctc cagcacgtcg gtatcgctgt ggcggtccac gacgaccgca ccggcgcggc 300 ggacagccgt cgggttggac gntgtgcggc gatcagtccg gccagctccg cctcgggatc 360 agcggc 366 188 423 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 188 atactcaagc ttgctgcagc ttcctatgac tgctcccgaa acctgggggt gtgcctgctg 60 tgtatgcacg gcatacggac atccttcccc tgagacccgc ggtcgaacca gccacgtgtc 120 catcatcagg ggtcaacccc ggccaagggc gacggcacgc caagttcgcc gaccgttaac 180 ctagtgctgt tagcttcatt tgctgcgagc aaaacagctg gtcggccgtt aggaactgaa 240 ttgaaactca accgatttgg tgccgccgta ggtgtcctgg ctgcgggtgc gctggtgttg 300 tccgcgtgtg gtaacnacna caatgtgacc gggggaggtg caaccactgg ccaggcgtcg 360 gcgaaggtcg attgcggggg gaagaagaac tcaaagccag tgggtcgacg cgcaggccaa 420 cgc 423 189 453 DNA Mycobacterium tuberculosis 189 agcttgacgc ggagacggac acattgcgaa cattgatgac aaaatagaaa tcattgatgg 60 tttgagtcac caggccgatc aagccttcgc cgagccaaat tccaatcaag aggcccaagc 120 ccgtaccaat cagcccggca acgagggatt ccgtcattat cagccaaaat aactgctctc 180 gggttacacc caaacagcgc aatatggcga aaaacggtcg ccgttgcacg acattaaatg 240 tcacggtatt gtagattaaa aagataccca ccaacaaggc aatcaaactg agagcggtta 300 aattgaccgt aaaagcgtcc gtcatctgtt tgacggtgtc ccgttgggta tccgacgttt 360 ccatacgcac accggccggc agtctttgtt ggatgcgtgt tgcagtggcc tcatctttga 420 tgatcaaatc gatgtggctc agtcttccgg gca 453 190 402 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 190 atactcaagc ttcggctcag gcggcgctgc tggtaaagtc gctgaccggt gcaggtttcg 60 acaatgtggt gccggttcgg cggctacgtg ccatcgagac actggcgcag gctatcgcac 120 ccgttatcgg ctacgagcaa atcgcggtat gcgttcttga gcatgagtcg gcgaccgtcg 180 tcatggtcga cacccacgac ggaaagacgc agatcgccgt caagcatgtg tgccgcggat 240 tatcaggact gacctcctgg ctgaccggca tgtttggtcg cgatgcctgg cgcccggccg 300 gcgtggtcgt ggtccgctcg gatagcgagg tcagcgaatt cncntggcag ctccaaaggg 360 tcctgccggt gccggtcttt gcgcaaacna aggcncaggt ta 402 191 427 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 191 tgatcgcgca tcacctgctt cataaactgg aagcagcgca gcgcttcctt ttcggccgca 60 acatgagcca gcctctcgtc ggcggtcggg tgcaggtgct cgggcagctc ggccgcgaca 120 gccgcctgac cctgaaacca gcttccatat cccgcgacga acgacgccag tccgctacgt 180 aacccctccg cgactgtcca tggacaacag cgcgttctcc accgaccggg cccgggtgtg 240 gggtgtttcg gcgaccggca gccaggtggt ccacactgcc gacgggcgcc gcgagccgtt 300 caccgaccag gccgccgagc aagtccgccc gatcgcatac tccaaccggt tgcggtactg 360 caggttcagc tggcgtactc ctcgtcgcgc tcggcgaggt cttgctccag cacgtcgcan 420 acggcag 427 192 347 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 192 caaagcgcga actgctcgcg gcagcccacg acgtgctgcg tcggattgcc ggcggcgaaa 60 tcaattccag gcagctcccg gacaatgcgg ctctgctggc ccgcaacgaa ggactcgagg 120 tcaccccggt gcccggggtc gtggtgcacc tgccgatcgc acaggttggc ccacaaccgg 180 ccgcttgatg cccggtcggc aagcccggca gttgccaaac ccagcgtgat caggctcggc 240 tcgcgagttc cgggaagaag tggctccgcc tgatcaccta ccatccgcca ggatctgcgt 300 gtcttcacca cgcccgccaa ggaggttgtt gtggtgctat cgaccgn 347 193 330 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 193 ccggaagccg catgatcagc caagtttcgc gccgcccggc atacggcggc gtaccgatct 60 ccgcgtcata cacccgcggg taatcgccga cggtgccggt tcgcgagccg aaggtgacga 120 cgctgattga atcgagttcc aggtccagcg ggtggcgcag caacggcgcg agctcaacga 180 cgtcaatcac gttgtcgctt tctacggtca ccgacccggt gaccgtngtc gcccggtgcg 240 ctcggccgaa aanttgcacc gccaccaccg cgaaaccgtc ttgcacnccg gaagccaccc 300 ccgatccgtt gttgggccag gttattgggt 330 194 215 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 194 ccggaaccgc cgacggcacg gtataacgcc tccgcatatg ggtcgacaac cagcgggtcg 60 gacttctggg cttctagcgt tcgcgcngtc gcgacaaaca gcgcggtcga accgacactc 120 gttgtgatgt cctagctatc acgttcggta cgcacccaat cgagtctagc gcgggtagnt 180 cagccccgat ctccangctc cgccgagcca ggcgc 215 195 225 DNA Mycobacterium tuberculosis 195 ctggtttatg tcccgttgaa gttccatcac ccgatgtggc gggagcactg ccaggtcgat 60 ctcaactacc acatccggcc gtggcggttg cgcgccccgg ggggtcggcg cgaactcgac 120 gaggcggtcg gagaaatcgc cagcaccccg ctgaaccgcg accacccgct gtgggagatg 180 tacttcgttg aggggcttgc caaccaccgg atcgcggtgg ttgcc 225 196 161 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 196 ccgagcagtt gggaatcgct ctgcancaaa ccaatattct gcgcgacgtc gcgcgacgag 60 ctggaccgat taggcgtacg cctccgnctg gacgacaccg gggcactcga tgaccccgac 120 gcctacgctc gcaggatatt gttcgccgga cccctctcta g 161 197 240 DNA Mycobacterium tuberculosis 197 tatataatac tcaagcttgc cgacgccaac gctcgcgcga tgttgttagc ccgacccggc 60 tcttacatgg caccggtgcc ccacacgtca gcctgtgacg tcctgcaccg cgactcttta 120 catagaatgt ggattgccgg attggggatg tccggcatcg ctcaatctgt agtccgcgtt 180 gtcccgcgag ggccatgtgg atggggggaa ggatccgtgg cgtccgggat caccatgggg 240 198 348 DNA Mycobacterium tuberculosis 198 atactcaagc ttgccgaagt tccgatgggt cgcgccggcg agcccaacga aatcgctagc 60 gtggccgtgt tcttggcttc ggatctatcc tcgtacatga ccggcaccgt gttggacgtg 120 actggcggcc ggttcatatg acaccgagat cattgccacg gtacggaaat tcgtccagaa 180 ggaaatcttt cccaatgcac cggccctcga acgtggcaac agctacccgc aagaaatcgt 240 caatcggctg ggtgttattg gcttgctcgg tcgccggctg cgagggtttc tacaccaccg 300 agttcattct cgggcgtgcc ggcgcattcg aactggcggt gcgcgctg 348 199 371 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 199 gcaccggcgt cctgcagttg gtaggcctgc agtttgtgca tcaggccgat gccgcggccc 60 tcgtggccac gcatgtacag caccacgccg cgcccctcac gggcgaccat cgccagcgcg 120 gcgtccagct gaggcccgca atcgcagcgg cgtgacccaa acacatcgcc ggtcaagcac 180 tccgaatgca cccggaccag cacgtcttca ccgtcggcgt tgggcccggc gatctcgccg 240 cggaccaacg cgacatgttc cacgtcctcg tagatgctgg tgtagccgat ggcgcgaaac 300 tccccangac aagtcggaat ccgcgcctcg gcgaaccgct caatgtgcct ctcgtgcttg 360 cgccgccatt c 371 200 165 DNA Mycobacterium tuberculosis 200 tggtccgtgt gcgcatacca atacaacgcg ccgggcacct gacgcggcgg ccgcaaccaa 60 tcggtggcca tcgccatctt ctgctacccg gtcaacggac gcaccttctc ctggccgacg 120 tagtgcgccc acccgccgcc gttgcgtccc atcgatccgg tcaac 165 201 390 DNA Mycobacterium tuberculosis 201 ggcgtgttgg ccaccggggc cactccgcac aatctgtacc cgaccaagat ctacaccatc 60 gaatacgacg gcgtcgccga ctttccgcgg tacccgctca actttgtgtc gaccctcaac 120 gccattgccg gcacctacta cgtgcactcc aactacttca tcctgacgcc ggaacaaatt 180 gacgcagcgg ttccgctgac caatacggtc ggtcccacga tgacccagta ctacatcatt 240 cgcacggaga acctgccgct gctaaagcca ctggcgatcg gtgccgatcg tggggaaccc 300 actggcgaac ctggttcaac caaacttgaa ggtgattgtt tacctgggct acggcgaccc 360 ggcctatggt tattcgacct ccccgcccaa 390 202 427 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 202 cgtccgtgnc ccctcaancg cgtgnngccg aagcggctgg ttacgactcc ctgtttgtga 60 tggacacttc taccaactgc ccatgttggg gacgcccgac cagccgatgc tggaggccta 120 cacggccctt ggtgcgctgg ccacggcgac cgancggctg caactgggcg cgttggtgac 180 cggcaatacc taccgcagcc cgaccctgct ggcaaagatc atcaccacgc tcgacgtggt 240 tagcgccggt cgagcgatcc tcggcattgg agccggttgg tttgagctgg aaacaccgcc 300 agctcggctt cgagttcggc actttcagtg accggttcaa ccggctcgaa gaggcgctac 360 agatcctcca gccaatggtc aagggtgagc gcccaacgtt tttcggcgat tggtacacca 420 ccgaatc 427 203 498 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 203 ccgcttccgt gtaaccgagc anngcgagcg anctggcgag gaagcaaaga agaactgttc 60 tgtcagatag ctcttacgct cagcgcaaga agaaatatcc accgtgggaa aaactccagg 120 tagaggtaca cacgcggata gccaattcag agtaataaac tgtgataatc aaccctcatc 180 aatgatgacg aactatcccc cgatatcagg tcacatgacg aagggaaaga gaaggaaatc 240 aactgtgaca aactgccctc aaatttggct tccttaaaaa ttacagttca aaaagtatga 300 gaaaatccat gcaggctgaa ggaaacagca aaactgtgac aaattaccct cagtaggtca 360 gaacaaatgt gacgaaccnc cctcaaatct gtgacagata accctcagac tatcctgtcg 420 tcatggaagt gatatcgcgg aaggaaaata cgatntgagt cgtctggcgg cctttctttt 480 tctcaatgta tgagagcg 498 204 265 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 204 tgacacccaa cagagggcac ttaagatggc aatgcggccg cctacctgca cgttttcgcg 60 atgtcagagg atgccgaggg agaacaatgc gagcacggcc gctgacnttg ctcaccgctt 120 tggcggcggt gacattggtg gtggttgcgg gctgcnaggc ccgantcnag gccgaagcat 180 atagcgcggc cgaccgcatt tcgtctcgac cgcaagcgcg acctcagccg cagccggtgg 240 agctactgct gcgcgccatc acgcc 265 205 369 DNA Mycobacterium tuberculosis 205 acgggcgacg ctgaggtggg cccgcggcta ttcatgctgt cgtccacgtc cagcgacgca 60 ctgcgccaga cggcccgcca actagccacc tgggtggaag aacaccagga ctgcgtggcg 120 gcctcggatc tggcctacac gctggcgcgt ggccgcgcgc accggccggt gcgcaccgcg 180 gtggttgccg ccaacctgcc ggagctcgtc gagggtttgc gcgaggtggc cgacggtgac 240 ccctctatga cgcggcggtg ggacactgtg atctaagacc ggtctgggtc ttctccgggc 300 aagggtctca gtgggcggcg atgggcaccc aattgctcgc cagcgaacca gtgttcgcgg 360 ccaccatcg 369 206 428 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 206 atactcaagc ttcgcgagat ccggatggca ctcacgctgg acaagacctt cacaaaatct 60 gaaatcctga cccgatactt gaacctggtc tcgttcggca ataactcgtt cggcgtgcag 120 gacgcggcgc aaacgtactt cggcatcaac gcgtccgacc tgaattggca gcaagcggcg 180 ctgctggccg gcatggtgca atcgaccagc acgctcaacc cgtacaccaa ccccgacggc 240 gcgctggccc ggcggaacgt ggtcctcgac accatgatcn aaaacttccc ggggaggcgg 300 aggcgttgcg tgccgcccag ggcgaaccgc tgggggttct gccgcagccc aatgattgcc 360 gcgcggctgc atcgcgggcg gcgaccgcca ttcttctgcg aatacgtcca ggagtactgt 420 ctcggggc 428 207 378 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 207 agcttatgtg gccgcccacc taccttatct agcctagcta actaaatcca gtgccgacag 60 tgcgcggctg gccacccagc atgaggttat gaccacggca tatgccagcg cgctggcggc 120 gatgccgacg ctgaccgagt tggccgctaa tcacaccagc catgcggtgt tgctgggaac 180 gaatttcttt ggaatcaata cgatcccgat cgcgctcaat gaggccgact atgcgcggat 240 gtggattcag gcggccacca cgatgagtat ctatgagggc acctccgatg cggcgctggc 300 gtcngcaccg caaaccacac cggctccggt actgttcaac ggcggtgctg gcgtttgcca 360 gcgcctgccg gcgatctc 378 208 284 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 208 atactcaagc ttgccaccca tgccgagcaa ggtcgactca gcgatgacga attgttcttc 60 ttcgcggtgt tgctgctggt tgcgggctat gagagcactg ctcatatgat tagcacnttg 120 tttctgacgc tggccgacta tccagatcag ctgacactcc ttgcgcagca accagacctg 180 atcccgtcgg cgatcgagga gcacctccgc tttatatcgc aatccaaaac atctgccgca 240 caacgcgcgt cgactattcg gtcggtcaag cggtcatccc ggga 284 209 236 DNA Mycobacterium tuberculosis 209 ccggggtaga acgatgcgat ctgggccatg tcgacatcgg tggtacaggt aaaccgcgcc 60 gtgtgcgcgg tctcggagat cagaacgtgg tcgcagttga caccgcgggc tttcagccag 120 tcgcgataat cggcgaagtc ggcgcctgcc gccccaacta gcgcgacctc gccacctagc 180 acaccgatgg cgaaggccat gtttccggcc acgccgccgc ggtgcatcat caactc 236 210 278 DNA Mycobacterium tuberculosis 210 atactcaagc ttggcggcaa cgccactacc gggctcacca ggtcctgtgc cgccaccgcc 60 ggcgccgaaa gcaccatcag gtcgtagttg tctggacgtt cgacaccgta agcgaacaca 120 atgccgccgc ccatgctgtg cccgagcacg atgcgcttgc acccgggata ttcccgggtg 180 gcgatcccaa cgagggtgtc gaagtcagcg gtgtatctga gatgtctctc actatcatcc 240 gtttggcacc cgagcgggca tgcccgcggg gggtcaac 278 211 360 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 211 gtcgacggca tcaaggtccg cagtgatggt gttcatctca cccaggaagg cgtgaagtgg 60 ctgataccgt ggcttgagga ttcggtgcgg gtcgccagtt aatccgccgt gtgctccgga 120 tgagcgcgac ggtaaccctg gaattgtgct gtgtgctggc tgtgtcgttg tgatgagcct 180 gtctaagtgg tgcgtaaccg tttgacgagc cgcggcctcg ctgcaaacat tgaagcccgc 240 acgtctgggt ttgtatttac acaacgaggg cgctccccga tctggcgcgc gcaacgaggt 300 gcncactatc cattcgaggt gaactggact ccttgatgct catgccggtg cggttttgtc 360 212 256 DNA Mycobacterium tuberculosis 212 atactcaagc ttgcgttcga tgaagtagtc gtcggtcagc gccgcctctt cgagctcctt 60 ggcgatgccc agcaaggagt catcgccgcc gagcttggcc aggatcttgt cggcctgttc 120 cttgacgatg cgggcccgcg gatcgtagtt cttgtagaca cgatgaccga aacccatcaa 180 tttgaccccg gcctcgcggt tcttgacctt gcgttacaaa ctcgctgacg tcgtcgccgc 240 tgtcgcgaat gccctc 256 213 262 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 213 ngtcaagccg agcatgcgcg aggnaacgac gaacccaaca agccatggtg gttggcgccg 60 tcgagaggtc ggcggtcgcc acaacgggaa gatcgccttg agcgtcgctc gaccgccgcc 120 tcgagttggg tcataacgaa gtagctgatg ccgatcatgt cgacgtttcc gtcgcatcag 180 cgtgcagcgg cgacccactc gacgaggtct cggtgccgcc gcggccaggg caccagcagt 240 gacgattcca ggcgccgtcg gg 262 214 336 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 214 cgataatcgc ttccggtaag tgcagcagct ttacgacggc gactcccatc ggcaatttct 60 atgacaccag atactcttcg accgaacgcc ggtgtctgtt gaccagtcag tagaaaagaa 120 gggatgagat ctccccgtgc gtcctcagta agcagctcct ggtcgcgttc attacctgac 180 catacccgag aggtcttctc aacactatca ccccggagca cttctagagt aaacttccca 240 tcccgaccac atataggcta aggtaatggg cattaccgcg agccattact cctacgcgcg 300 caattaacga atccaccatc ggggccgctg gtgtcn 336 215 259 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 215 naatactcaa gctttctcgt gattaccacc cgtgtaattt gggatgggca aaaaggcgaa 60 tcaccgcgtg gccacaaacg ccgggaggga caatctcggg cggctagggc ttctcgcggg 120 aaggcccgaa cgtacggcgt ttcaacacgt cgcgtcgccc tccgaccgcg aacattcggg 180 gatggcagca acctggtatc accctggccg ggcaatgatc tgcagcgtcg ccgcgggtag 240 tgnccgcccg ggcggctac 259 216 325 DNA Mycobacterium tuberculosis 216 ccaactagag catcgggaca tacggagtca actacccggc caacggtgat ttcttggccg 60 ccgctgacgg cgcgaacgac gccagcgacc acattcagca gatggccagc gcgtgccggg 120 ccacgatgtt ggtgctcggc ggctactccc agggtgcggc cgtgatcgac atcgtcaccg 180 ccgcaccact gcccggtctc gggttcacgc agccgttgcc gcccgcagcg gacgatcaca 240 tcgccgcgat cgccctgttc gggaatccct cggggccgcg ctggcgggct gatgatcgcc 300 ctgacccctc aattcgggtc caaga 325 217 300 DNA Mycobacterium tuberculosis 217 atactcaagc ttgctgcagc ttcctgtgac tgctcccgaa acctgggggt gtgcctgctg 60 tgtatgcacg gcatacggac atccttcccc tgagacccgc ggtcgaacca gccacgtgtc 120 catcatcagg ggtcaacccc ggccaagggc gacggcacgc caagttcgcc gaccgttaac 180 ctagtgctgt tagcttcatt tgctgcgagc aaaacagctg gtcggccgtt aggaactgaa 240 ttgaaactca accgatttgg tgccgcccgt aagtgtcctg gctgccggtg cgctggtgtt 300 218 265 DNA Mycobacterium tuberculosis 218 agcttgcgcg gcgtggcgat cgcggttcaa ggcgcgctct tcgagcacaa cgagcgaaga 60 cagctcggcg acggagcctt tatcgacatc cgttcgggct ggctgaccgg cggcgaagaa 120 ctgctggacg cgttgttgtc gacggtgccg tggcgagccg agcgccgtca gatgtacgac 180 cgggtggtcg atgtgccgcg gctggtgagt tttcacgacc tgaccatcga agatccgccg 240 catccgcagc tggcgcggat gcgcc 265 219 362 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 219 aatactcaag cttgcgcacg accaggacgt cgagtggcgc ttgcagtgac ttggcgacct 60 caaaggccac cggtaccccg ccgcgcggca agccaaggac nacnacggcc ttgccggata 120 gctgcgccag gcgttgcgcc aactggcgtc cagcgtcgcc acgatcgtca aagagcttca 180 tctgccgagt gtgtcgccat ctcatggctc caaatatgga attaggtccc tgggccgact 240 gacgacagtc cctcagcgac cggattgcgc atcccgcctt gtacgctgct ccgcaaatcc 300 cgggcttgcg tccgcggaag cgaactcggc ggcgctacgg tggtggctca cttcggccgt 360 gc 362 220 486 DNA Mycobacterium tuberculosis 220 ggttggtgcg gtccaccttc gcggcggcgg cgcgatatgc cttgctggtc ttgctcattt 60 gatatccaat ctatgggtcg tggttactca gcgggccgaa gctggccctc ccacgggtag 120 ggccctattc gacggtgatg cccatcgacc gagcggtacc ggcgatgatc ttggccgcag 180 cgtcgacgtc gttggcgttg aggtccgtct tcttggtctc ggcgatttcg cggacttgat 240 cccaggtgac tttggcgacc ttggtcttgt gcggctccgc cgaacccttc gccacaccag 300 cggccttaag cagcagcttg gcggcgggcg gcgtcttcag cgtgaaagtg aagctacggt 360 cttcataaac ggtgatctcc accgggatga cgttgccgcg ctggttctcc gtcgcggcgt 420 tgtacgcctt gcagaactcc atgatgttga cccgtgctga ccgaacgcgg ggcccactgg 480 cggggc 486 221 373 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 221 atactcaagc ttttcgaccc gcaagccggc ggtgcccctc ctcgttccgc tgcccggtct 60 gctcgatcgg ttcggggtcg ccgcgctagg cccaattgcc cggctcctcc tcgggccgtt 120 ccacaacccg catcgtcgcc gggctaggtt caagccatgc cggtaaaccc caggacgcca 180 gtgctgatcg gctatggaca ggtcaaccac cgaggcgaca tcgacgccna aaatcagtcc 240 atcgaacccg tcgacctgat ggccnccgcg gcccggaaag ccgccgagtc caccgtgctc 300 gaagcggtgg attccatccg tgtggtgcac atgctgtcgg cgcattaccg gaattcccgg 360 gcgtctcctc ggc 373 222 331 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 222 ncctggttca tgaactggaa gcagcgcagc gcttcctttt cggccgcaac atgagccagc 60 ctctcgtcgg cggtcgggtg caggtgctcg ggcagctcgg ccgcgacagc cgcctgaccc 120 tgaaaccagc ttccatatcc cgcgacgaac gacgccagtc cgctacgtaa cccctccgcg 180 actgtccatg gacaacagcg cgttctccac cgaccggggc cgggtgttgg ggtgttcggc 240 aacggcaacc aagttggtcc acactgccga cgggcgccgc aaatccgttc accgaaccag 300 gccgccnaaa caattccgcc cgatcccata t 331 223 377 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 223 atactcaagc ttgtcgggat caatctcgag ggcatccacg cacgaaaagt aaactctatc 60 aagctttttg acgacaccca cggacgcccc atatatgttc gggtgggcaa gaacggtccc 120 tacctggaac gtttggtggc cggcgacacc ggtgagccca cgccgcagcg ggccaacctc 180 agcgactcga ttaccccgga cgaactgact ctacaggtgg ccgaagagct ctttgccaca 240 ccgcaacagg gacggacttt gggcttggac ccagaaaccg gccacgaaat ctttgccagg 300 ggaaggccgg tttgggcctt atgttaccta tatcctgccg gaacctgcgg ctgatgcggc 360 cgcggccgct cagggan 377 224 436 DNA Mycobacterium tuberculosis 224 agcagctagc cgcgctcgcc gcgctggtcg gtgcgtgcat gctcgcagcc ggatgcacca 60 acgtggtcga cgggaccgcc gtggctgccg acaaatccgg accactgcat caggatccga 120 taccggtttc agcgcttgaa gggctgcttc tcgacttgag ccagatcaat gccgcgctgg 180 gtgcgacatc gatgaaggtg tggttcaacg ccaaggcaat gtgggactgg agcaagagcg 240 tggccgacaa gaattgcctg ggctatcgac ggtccagcac aggaaaaggt ctatgccggc 300 accgggtgga ccgctatgcg cggccaacgg ctggatgaca gcatcgatga ctccaagaaa 360 cgcgaccact acgccattca agcggtcgtc ggcttcccga ccgcacatga tgccgaagaa 420 ttctacagct cctccg 436 225 539 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 225 cgcgactggc tccccggncg gctgctcggg tccgccgata gagaccggga tgtcgcccga 60 cgacgggcag ccgggttgcg tgggacgggg cgggggtcgg gcagcccaag caacgggcta 120 gtccccgaat cctacggagc cgtcacctac gcctacgtaa tagtagctat caataacagt 180 tgacatacgc aacgatctgt gagatcaata ttgcctgacg catgtcaaga caggcgtcaa 240 gacaggtgtc aataattcgc tccgctggtg acggtaaccg gtcgtgcggg tgtgtgacgc 300 ctaaggaagg agtgtgggtg gtgacgctga gagtggttcc tgagggtttg gcggccgcca 360 gtgcggcggt ggaggcgttg accgcacggc tggccgccgc acacgctggc gcggcgccgg 420 cgattacggc ggtggtggcg cccgcggcgg atccggtgtc gttgcagaat gcggtggggt 480 ttagcgcctt aagtagccag catgccgcga tcgccggcga aagggtccaa gaactgggt 539 226 517 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 226 atactcaagc ttattgaacc gcgggtcgca ggcaaagtgg acctcataac gactcgggtc 60 cagcgaccgc gccaacacga acggccggac gacgtgggcc agggtcgcgg cctcccctac 120 aaacaggatc cgttgcctgc gaacgacagg ctccggtgcg gcgttgggcg ccgtgctcgt 180 cccagcgtcc ggtcccgggt cgccggcgac gcttgtttcc tccatactcg ccccctaatc 240 tcgaggcagc ccgtacccgc aggcaacctc ccaaaaatgc aatcccgcaa aatgcaatgc 300 gtcnagctat ttctcacacc gaccgctagt tgcggatcag aaatccgttg ggcgcggaag 360 tccagccgaa tttgttctcc cgctccgcat catgcttgta atcgtttgga aattcatcct 420 catatgcctc gatcgcttca tagggtccag gcccaaaccc gggcaggact gggtggccgt 480 tgatgttgga atcctccact actaggtatt caccggc 517 227 488 DNA Mycobacterium tuberculosis 227 gtctcgatca tggccaaaga gctcgacgaa gccgtagagg cgtttcggac ccgcccgctc 60 gatgccggcc cgtatacctt cctcgccgcc gacgccctgg tgctcaaggt gcgcgaggca 120 ggccgcgtcg tcggggtgca caccttgatc gccaccggcg tcaacgccga gggctaccga 180 gagatcctgg gcatccaggt cacctccgcc gaggacgggg ccggctggct ggcgttcttc 240 cgcgacctgg tcgcccgcgg cctgtccggg gtcgcgctgg tcaccggcga cgcccacgcc 300 ggcctggtgg ccgcgatcgg cgccaccctg cccgcagcgg cctggcagcg ctgcagaacc 360 cactacgcag ccaatctgat ggcagccacc ccgaagccct cctggccgtg ggtgcgcacc 420 ctgctgcact ccatctacga ccagcccgac gccgaatcag ttgttgccaa tatgatcggg 480 ttctcgac 488 228 264 DNA Mycobacterium tuberculosis 228 atactcaagc tttcgtcagt tcatggcgcc agcagaccaa caagagcatc gggacatacg 60 gagtcaacta cccggccaac ggtgatttct tggccgccgc tgacggcgcg aacgacgcca 120 gcgaccacat tcagcaaatg gccagcgcgt gccgggccac gaggttggtg ctcggcggct 180 actcccaggg tgcggccgtg atcaagatct tcaccgccgc accactgccc ggcctcgggt 240 tcacgcatcc gtttggccgc cgcc 264 229 229 DNA Mycobacterium tuberculosis 229 gccccgtgta atttgggatg ggcaaaaagc gaagcaccgc gtggccacga acgccgggag 60 ggacaatctc gggcggctag ggcttctcgc gggaaggccc gaacgtacgg cgtttcaaca 120 cgtcgcgtcg ccctccgacc gcgaacattc ggggatggca gcaacctggt agcaccctgg 180 ccgggcgatg atctgcagcg tcgccgcggg tagtctccgc ccgggccgc 229 230 266 DNA Mycobacterium tuberculosis 230 atactcaagc ttcctttgac cgaacgcgtc caccgcaccg tgagattggt ggcgccattc 60 gtcgtggtgt agctgctgtt ggcggcgtcg ccgtattgtg cgggccagcc ttgtgcgggg 120 gccgcttcta cccacaagtc ggcacttccg caaccgccca gctcgaccgc gaattacggc 180 ggccgcaacg gccgccggaa ggcgtcacgc aatcgcttat cctttccagg ttcccaaatc 240 ctccgcttac ttgggtcctt catcgg 266 231 258 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 231 ggcagcggcg acaaccggaa cgtccgcacg gtgctcaatc acgggtgcac ggtgtgcatc 60 agaatggcgg gggttcgttg tcgcggtgag gcgttcggcg aggaggtagt gtctacccct 120 tgcccgcggg ttcgtgcgga ctgaaaggga tttcattggg aacccacggc tgcgtatcgc 180 agggcctcgg tgacgtctgc ttcctcnagc tcaggaagtt cggcgagaat ctcggtggat 240 gttatttggt ccgcctac 258 232 224 DNA Mycobacterium tuberculosis 232 atactcaagc tttctcggct tctctgatag cctgagaaga aaccccaagt taatccgctg 60 cttcacctat tctccagcgc cgggttattt tcctcgcttc cgggctgtca tcattaaact 120 gtgcaatggc gatagccttc gtcatttcat gaccagcgtt tatgcactgg ttaagtgttt 180 ccatgagttt cattctgaac atcctttatt cattgttttg cgtt 224 233 333 DNA Mycobacterium tuberculosis 233 atactcaagc ttggtgaccg gcaccgcgat acgttgcggc aggcatctgg gctggcggtg 60 gttcgccgct ccgaagccgt cgaacaccat cgccagcgcg gcttccacat caacgaccat 120 ttcggccagc ttgcggcgca tcagcggctt gtcgatgagc gccccaccga atgcccgccg 180 ctgcccggcg tatcacatcg attcgaccat cgcgcggcgc gcgttgccga gggcgaacga 240 ggcggtgccc aaccgcaatc tgtttggtca gctccctcat gcgggttgat tccttgccgt 300 ccggacgggc ccgcgtcatg cgctcggttc gcc 333 234 407 DNA Mycobacterium tuberculosis 234 ccgttgcgca gcgtgagccg atagttgaca tccggctcgg tgaaggtgaa atcgatggcc 60 aggtcgaggt cccatgcgcg tgggccattg atgctgatcg ccaggacgtc aaagatttgg 120 tccggcgtca gctgggcgaa aaacgtgggc gccgggactt gcccggagct gcccgggttc 180 ccgtcgcgca gctcggcggc cccggtcaga aagaaattgc gccaggtcgc acactccgcg 240 ccgtaggcca gctgctccag ggtgtcggca tagagcccgc gggccgcagc gtgctcgctg 300 tcggcgaaca ccgcatggtc gagaagcgtt gccgcccaac gggaaatcac ctgcgtcgaa 360 agcttcgcgg gccagctcca gcactcggtc gatgccaccc aacgcgt 407 235 389 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 235 atactcaagc ttgcggatgt tacccctgac agcgtgaact atgtcnaaac acacggcacc 60 ggaacggtgt tgggggaccc catcgagttc gagtcgctgg cggccactta tggcctgggt 120 aaaggccagg gcgagagccc gtgcgcattg gggtcggtca aaaccaacat cggccacctg 180 gaggcggccg ccggtgtggc tggattcatc aaggcggtgc tggcggtgca acgtgggcac 240 attccccgca acttgcactt cacccggtgg aacccggcca tcaacacgtc ggcgacgcgg 300 ctgttcgtgc cgaccgaaag cgccccgtgg ccggcggctg ccggtccacg cagggctgcg 360 gtgtcatcgt tcggcctcag cgggaccaa 389 236 432 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 236 ccggtaacca gatcagctcg tcgacctcac tgccgggggt gaattcccca ccggtgctgc 60 gcgctgccca gtagtgcacc ttcttgacgc ctcgaaaagg ggagtcggtc gggtaggtca 120 ccgtcaggag ccgcctaccc aggttggcgc ggtgaccggt ctcctcgagt atctcccgca 180 ccgcccccac cggtgcggtc tcgcccggat ccactttgcc cttgggcagc gaccagtcgt 240 cgtaacgggg gcggtgaatg acagcgatct cgaccggccc ttccgaatcg gcactgccgg 300 gtcgccagaa caccgcaccg gcggcgtaca caatccggcc cgccgagcgc cggcgggcgg 360 acganttctg gatcgacacc tcaactcctg caggtcaatt cggccaagct gctcgcggtc 420 gtggatgtgg tc 432 237 287 DNA Mycobacterium tuberculosis 237 atactcaagc ttgatgccgc cgaaaccgag cgtgagcacg ccgccaccca ccacgcgcgg 60 gtcgggcgcc gggcccgggc cgccaggctg ctccgctcgg tgatggcacg ccaccgcgac 120 accacccggc tgcgctacgt cgagccatac cgggcggagc tacatcggct cggccgccca 180 gtgttcgggc cctctttcga ggtcgaggtc tataccgatt tgcgcatccg cagccgcacc 240 ctggtcgtct cgtaccgtgc cctacctctg cttgtcgggc ggggcca 287 238 272 DNA Mycobacterium tuberculosis 238 tccgtacggc ccgggtacgc ttcggtcgca gtgtgcgagt gatagatgac gaccgggacc 60 tcgtcggcat cttccatagc ccgccacacc ttcagttgct caccggaatc caaccggtag 120 aaggtcggcg agcgctcggc attggtcatc gggatatgcc gctcgggacg gtcagagccc 180 tcgggtccgg ccagcactcc gcaggcttcg tcggggtggt cgcgacgcgc atgggccacc 240 atccatccac caggtctgcg cgaatcaccc gc 272 239 410 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 239 ggacacattg cgaacattga tgacaaaata gaaatcattg atggtttgag tcaccaggcc 60 gatcaagcct tcgccgagcc aaattccaat caagaggccc aagcccgtac caatcagccc 120 ggcaacgagg gattccgtca ttatcagcca aaataactgc tctcgggtta cacccaaaca 180 gcgcaatatg gcgaaaaacg gtcgccgttg cacgacatta aatgtcacgg tattgtaaat 240 taaaaagata cccaccaaca aggcaatcaa actgagagcg gttaaattga ccgtaaaagc 300 gtccgtcatc tgtttgacgg tgtcccgttg ggtntccgac gtttccatac gcacaccggc 360 cggcagtctt tgttggatgc gtgttgcagt ggcctcatct ttgatgatca 410 240 439 DNA Mycobacterium tuberculosis 240 gcctggccca ggtgaaggcc gacctcgacg ccaaagccgc tgatccggca catgagtcgg 60 tggactggga cttgaagtcg ctgcgatggg cgtggaaccg agccaaagat gacgtggcgc 120 cgtggtgggc cgagaattcc aaggagtgct actcgtcggg gttggccgat ctggcccagg 180 gcctggctaa ttggaaagct ggcaagaacg ggacccgcaa aggccggcgg gtgggcttcc 240 cgcgattcaa atccgggcgg cgtgatcctg gcagggtgcg gttcaccacc ggcaccatgc 300 gcatagagga tgaccggcgc acgatcacgg tcccggtgat cgggccgctg cgggccaagg 360 agaacacccg ccgggtgcaa cgccacctcg tgagcgggcg cgcgcagatc ctgaacatga 420 ccttgtcgca gcggtgggg 439 241 356 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 241 taactcaagc ttcaagtccg cngtccgacc ctgttcgacg gctacctgaa tcaacccgat 60 gccccgccgc ggcgttcgac ccgacagctg gtaccgcacc ggcgacgtcg cggtggtcga 120 cggcagtggg atgcaccgca tcgtgggacg cgagtcggtc gacttgatca agtcgggtgg 180 ataccgggtc ggcgccggtg aaattgaaac ggtgctgctc gggcatccgg acgtggcgga 240 ngcggcagtc gtcggggtgc tcgactatta tctaggccag cggatcgttg cctacgtagt 300 cggctcagcg aatgtcgatg cggacgggct tatcaacttt gttgcccaac aacttt 356 242 341 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 242 ccatgtcgcc caacatatcg tcgatgttcg cgtcgtccgc ctcgcgcacg tggtctgtca 60 ccagtcaacg ttaacgccgc cgcacatgtc ctgcggccgg gcaaaaacgt gaaaaacgag 120 cgggcgactg caatgtcatg acaccgacgc cgccgatggg cccagggtct ggcagattcg 180 atctgtgcgg ccagtgccag cagcgtcgcc tcgtcatacg gccggccgac gagttgaacc 240 gacatgggca tgccgtcgcc gtcgaagtcc cacggcacca cggccgcggg ctggccggtc 300 agattccana cttgaaagta ctgaagccgc tgcaccacca g 341 243 336 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 243 cgaaagcgtg aaacagctcg cggcagcccc cgacgtgctg cgtcggatag ccggcgggcg 60 aagatcaatt ccaggcagct cccggacaat gcggctctgc tggcccgcaa cgaaggactc 120 gaggtcaccc cggtgcccgg ggtcgtggtg cacctgccga tcgcacaggt tggcccacaa 180 ccggccgctt gatgcccggt cggcaagccc ggcagttgcc aaacccagcg tgatcntgct 240 cngctctnta nttcggcgaa gaagtggctc gcctgatcac ctaccatcgg ccaggatctg 300 cgtgtcatca caacgctcgc caaggaggtt gttgtg 336 244 337 DNA Mycobacterium tuberculosis 244 tccgccacgc ttcgcgccgc ccggcatacg gcgcgtaccg atctccgcgt catacaccgc 60 gggtaatcgc cgacggtgcc ggttcgcgag ccgaaggtga cgacgctgat tgaatcgagt 120 tccaggtcca gcgggtggcg cagcaacggc gcgagctcaa cgacgtcaat cacgttgtcg 180 ctttctacgg tcaccgaccc ggtgaccgta gtcgcccggt gcgctcggcc gagaagctgc 240 accgccacca ccgcgacacc gtcttgcacg cggacccacc ccggatcggt tgttggccaa 300 ggtaattggg tcattccatt tgacgggacg ccgaccc 337 245 337 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 245 cattctttaa cagttgtttt gggctcggca tggttagcca acgttctgcg gtccaccata 60 tcatcttggt ccggtagcgc tcgtccgggg tatgctgccg ccgggattct cgctgctatt 120 actccccccg aagaaccgcc accggtccag cgcgtgggcc gncgcggtcc catcacaaac 180 tgaaccccca acagggacat gcttatcggt agggcgcgcg ccaaggcggc agcaatcgca 240 tcactgcgct ctgcgcgtca ctattaaccc acccggactt cacttccacc accccgaatg 300 gcgcccggtc attgatcatc tggcgcaccg cggataa 337 246 343 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 246 cggtgtcctg cagttggtag gcctgcagtt tgtgcatcat gccgatgccg cggcctcgtg 60 gccacgcatg tacagcacca cgccgcgccc ctcacgggcg aacatcgcca gcgcggcgtc 120 cagctgaagc ccgcaatcgc agcggcgtga ccaaacacat cgccggtcaa gcactccgaa 180 tgcaccggac cagcacgtcg tcaccgtcgg cgttgggccc ggcgatctcg ccgcggacca 240 tgcgcgacat gttccacgtc ctcgtanatg ctggtgtagc cgatggcgcg aaactcccca 300 tgacgagtcg gaatccgcgc ctcggcgacc cgctcaatgt gct 343 247 340 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 247 cggcatctgg cggctgaacc tgttcttggg caacatgccg aggatcgcct cttccaccac 60 gcggtcgggg tggcgttgca ttacctcacc gatggtgcgc ttgtgcaggc cgccgggata 120 ccccgagtgc cggtaaacca tcttgtgctg cagtttgtcg ccgctgatgg cgaccttgtc 180 ggcgttgatc acgatnacna atcaccgcca ncgacattgg gggcgaacgt cggctcgtgc 240 ttgccgcgca gcaggctggc cgccgcgacg caaggcgcca accaccacgt ccgtggcgtc 300 gatgacgtac caccatcgcg tggtgtcacc cgccttgggc 340 248 322 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 248 gcggcaaaaa ttgaagcact cntggccact nccgccggga gggacaatct cgggcggcta 60 gggcttctcg cgggaaggcc cgaacgtact gcgtttcaac acgtcgcgtc gccctccgac 120 cgcgaacatt ctgggatggc agcaacctgt tagcaccctg gccgggcgat gatctgcagc 180 gtcgccgcgg gtagtcgccc ccgggcggct acagtctgaa acgcgatgac catcgatgtg 240 tggacgccgc atccgacnca acggttccta cactgtgata tgttcgcctc gctgcgccgg 300 tggacggtgg gtctatcccg ga 322 249 278 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 249 cgcgttgaac tgaaggggtg ccgcccggct cgagcaggca agccatttgt tcgatgcggt 60 taccgaagat ctcttcggtg actgcccgcc gccggccagc tcggctcagt gtccggcgtt 120 ggtcgccgcg gcgacaatct tggcgtccac ggtggtcggg gtcatgcccg cgagcaggat 180 tggcgagcgg ncggtcagcc gggtgaactt cgtcaagagc tgacgctgcg gttggggagg 240 cgaatcatgg tcggtgcgta gcctcgacta ggcccggg 278 250 336 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 250 tgacaacgcg gcggcgatta ccccgctacc gcagcagcat gacgcggtag cgaacaccgc 60 cggatgcagc gcaggtgcgt cgatgtgctc acggaatcgc cccggcaccg cgatctcgag 120 gatcaccagt gccaccccct gcagcgcgac accgacgatt ccgtacaccg ccacgccgat 180 caggccctgg gccagctgat tggagctggc gtatatggcg gcgatggtga cgatggtcat 240 cgcctcttac attgtggcgg ccagaaccac ggcgttgggg cggcggtcga tgaacactag 300 gcgaccanat ccccggggtc aacaggttga ccatcc 336 251 95 DNA Mycobacterium tuberculosis 251 cgcggacatc ccgaacgagg acacgcgacc gcttcggtgt gtgatctatc agggctcgca 60 ccacgcgcaa ccgcttccgg ctacctagac gcggt 95 252 94 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 252 gcatgcgggt gatgccgttc tcagtgcgca acagcgttcg acgcggcata cccagccgca 60 catgccgtgc acgccggngc cggggcggga atct 94 253 302 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 253 ctcaagcttc agnccntcta agcggtctgc gcggcgatcg caaagatcgc cctttgccgg 60 cgttgggggc ttctgctcgg gggtgttgta caccttctcg aacacctcgg caccgacacc 120 accaccgtcg gcttgaacac cgccaacatc ggcagcanat cttgatgtcc tggtgaatcc 180 acggtgactt tggagtggaa ggcggccata ctgatcgcgc gcgccaccac atgagctagc 240 ggcaggaaaa ccagcagccg ctcacccttg cgcagcagcg tcgggtgata tgcctggcgc 300 cc 302 254 291 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 254 agtcgaangt cagtccggtc tcctctccga ctacggccaa gaactggggc gacggtgtca 60 gtgcagaaca gcggaaactg gtggcgccct aggcgagcga acgctcacaa acggcggtga 120 ccgcttctgg tcgtgcacca tcgagccgtg cccagcccgg ccgcgtgccg tcagccgcat 180 ccactggatg cccttctcgg cggtttcaat cangtacagg cgacgttcgc caccatcgtg 240 ccggggcacg gttagcgaga aacgccgact tcaccgattg cctcggtgat g 291 255 454 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 255 agcttcgcgg cgtggcgatc gcggttcaag gcgcgctctt cgagcacaac gagcgaagac 60 agctcggcga cggagccttt atcgacatcc gttcgggctg gctgaccggc ggcgaagaac 120 tgctggacgc gttgttgtcg acggtgccgt ggcgagccga gcgccgtcag atgtncgacc 180 gggtggtcga tgtgccgcgg ctggtgagtt ttcacgacct gaccatcgaa gatccgccgc 240 atccgcagct ggcgcggatg cgccggcggc tcaacgacat ctacggcggc gaactgggtg 300 agcccttcac caccgccggg ctgtgctact accgcgacgg ctctgacagc gtcgcctggc 360 atggcgacac cattggtcgc ggcagcactg aggacactat ggtggcgatc gtcagcctcg 420 gcgccacccg cgtcttcgcg ctgcggccgc gtgg 454 256 346 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 256 agcttcagct gatactcgac cagccccact cgggccaata cgtgaatgtc tagcatcttc 60 acccgttcac gggctantcg agtagtagac attgattagc ctgaacgtac ctccgacgcc 120 agctgacgaa cgggtatgac ggatggattt cgtggtgtcg cgcccgaggt caattcgtta 180 cggatgtatc tcggggccgg atcggggccg atgttggcgg ccgcggcggc ctgggacgga 240 ctatccgacg aactggcggt ggcggcgtcg tggtttgggt cggtgacctc gggcctggcg 300 gatgcggcgt ggcgcggccc gcggcggttg cgatggcncg cgcggt 346 257 339 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 257 ctggtcatgg acgttgctcc ggtagtggct cactgccgat cctcctcgtt gagagtgcca 60 cctcagggtt gggtagggtt gggtactcga aaccaagtta cccaccagta acaccgtcaa 120 aatatatccg ttgcataggt caatgcaagt tgatgtgagc tacattgcac caactaacta 180 accaaccggt tgggttagcg gtgatcctgg ccgtgtcggt cctctcacct gcggtgatag 240 cgatcaaatg aagaatatgc ggagtctagg gcggcagcgc ctggcancgt agatcatcgg 300 ctcacgcgga tgcggcctct tggtacggac atgcgcgcg 339 258 182 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 258 ctcgtgagta gcacccctgt aatttgggat cggcaaaaag gcgaatcacc gcgtggccac 60 gacacgccgg gagggacnat ctcgggcggc tagggcttct cgcgggaagg cccgaacgta 120 cggcgtttca acacgtcgcg tcgccctccg accgcgaaca ttcggggatg gcagcaacct 180 gg 182 259 213 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 259 ggatcaacta ccggccaacg gtgattcttg ggcgccgctg acgcgcgaac gacccagcga 60 cacattcagc agatggccag cgcgtgccgg gccacgatgt tggtgctcgg cggctactcc 120 catggtgcgg cncgtgatcg acatcgtcac cgccgcacca ctgccggcct cgggttcacg 180 cagccgttgc cgcccgcagc ggacgatcac atc 213 260 321 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 260 aggaccgtca gcacggcgac gtgctactcg ccgagcagtg ggaatcgctc tgcagcaaac 60 cattactctg cgcgacgttc gagatgacct tctgaatgga cggatctacc tgccgcgcga 120 cgacctggac cgcgtatgcg tccgcctccg cctggacgac accggggcac tctatgaccc 180 cgacggacgg ctcgcggtac tgctgcggtt caccgccgac gcccgcacgg tacgcgtcgg 240 gactgcgctg agtccancct cgacgccgta gcgctgctgc tgtgcggcca tgtctggcat 300 ctaccgccgt cgctcccttg a 321 261 334 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 261 cgactctgtt ggccactgcg ggtcgatctt gcggccgccc cggtcgtgga acgcccaggt 60 cacccggcgg cgcaccgcgg tcagcgcgtc gttggccagc gtggtcacat ggaagtggtc 120 gacgacgagc ttggcgttgg gcagcagccc gggcgtgcgg atcgccgagg cgtatgcagc 180 ggcggggtcg atggccaccg tactggatgc tctcccggaa ctgcggtgtg cgcgcttgca 240 gccatgccag caccgccgcg ccgccgcggc cttcatgctg cccataaacc ctgataccgg 300 ccaggtcgac naaccngtat cccacggtca accc 334 262 208 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 262 cacacggacg gcggtgcgga cgcagctgac gcgcatggtg gtcagcatcg cggccggtct 60 gctgttgtat gcctacttcg cgccgcgcaa atgctggtgg gcggcggtgg tggcgctcgc 120 atggctgggc tgggtgctga cccaactctc gaaccacacc ggtgggtggg ctgggctatg 180 gcctgccata tcggcctggt gttctacn 208 263 233 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 263 ccgatatccg agccgatagc tggcgggctc gggtggtngc cagcggcgct gcgacgaaag 60 tgtgaccgtc atgaaacaga caccaccggc ggccgtcggc cgtcgtcacc tgctcgagat 120 ctcagcatcc gcagccggtg tgatcgcgct ttcggcgtgt agtgggtcgc cgcccgagcc 180 cggcaaacgc cggcccgaca caaccccgga acaggaagtc cggtcaccgc gcc 233 264 320 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 264 gcttcaggac aaattgnatc cctatgcacc cgttgtcacg ccgatgagtg aagactgcac 60 gcaatcgccg gaatccggca aaaccctgca caagcgaaat caaccggagg ctgacaaggc 120 aacgtcggtg atccgtaccg cctggttgga caaacggcag aaggcgcctc gtccggtcca 180 tctacgccga gcacactggt gatagcgcca tcggcatcgg tgcggccacg gtggagacga 240 acgtccgcng gcgtctgggt cagtaacccg ccgaccagtt ctcgggcaag ctggtcaaca 300 tcgggcgcca cgtctccaac 320 265 304 DNA Mycobacterium tuberculosis 265 gtttggcggc cttattgcac tgaggtcgtc aattgaccca cagcggaaat gccgactatt 60 cgcaggcctc cttcgccttg gctgccggag atgggctccg cgggaaccgc atgcaggtat 120 atgacctcgg tttctcgggt gctaccgcgt gccttgtcga ggatgaactc ggcgttggaa 180 ttgtccagcc ggcccaattc atcgagcgca gattcgtaca catggccggc ggcgacatac 240 cttcaccgtg gatctgctcc acacggaccg ccctgtcggg atctgctcac gggtaaagga 300 atta 304 266 217 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 266 gcgcactcct ccttatcgct ccgctctgca tcgtcgcggc gcggtcaggt gcaaacgcct 60 tcgggggtgg gggtcctgcg gagcacaccg gatacggagc gcaacgcgtc gcgttgtgcg 120 ggcaaacaag tgtgcaggnn ccaatgccat gtccagcagc ttatcagtgt cgaacgtgcg 180 aacgtcgcgc cttcgccggt gcctgaatct ctacaag 217 267 174 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 267 cgctgaaagc caccattcgc gggtcgggcg ccgggctcgg gccgccaggc tgctccgctc 60 ggtgatggca cgccaccgcg acaccacccg gctgcgctac gtcgagccat accgggcgga 120 gctacatcgg ctcggccgcc tagtgttcgg gncctctttc gaggtcgagg tcga 174 268 144 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 268 tgtaatttgg gatgggcaaa aagcaaanca ccgcgtggcc acaaacgcgg ggagggacaa 60 tctcgggcgg ctagggcttc tcgcgggaag cccgaaacgt acggcgtttc aacacgtcgc 120 gtcgcctccg acgcgaaatt cggg 144 269 216 DNA Mycobacterium tuberculosis 269 cttgggcaac atgctgagga tcgccttttc accacgcggt cggggtggcg ttgcattagc 60 tcaccgatgg tgcgcttgtt gcaggccgcc gggatacccg agtgccggta aaccatcttg 120 tgctgcagtt tgtcccgctg atggcgacct tgtcgcgttg atcacgatga cgaagtcacc 180 gccatcgaca ttgggggcga actcggcttg tgcttg 216 270 199 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 270 gcatgcttca ttatctaatc tccagccgtg gtttaatcag acgatcgaaa attcatgcag 60 acggtcccaa atagaaagac attctccagg caccagttga agaggttgat caatggtctg 120 ttcaaaaaca agttctcatc cggattgaac tttaccaact tcatccgttt catgtacaac 180 atttttagaa ncatgcttc 199 271 230 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 271 atactcaagc ttgatgccgc cgaaaccgag cgtgagcacg ccgccagcca ccacgcgcgg 60 gtcgggcgcc gggcccgggc cgccaggctg ctccgctcgg tgatggcacg ccaccgcgac 120 accacccggc tgcgctacgt ctatccatac cgggcggagc tacatcggct cggccgccca 180 ttgttcnggc cctctttcga ggtcgaggtc tataccgatt tgcgcatccg 230 272 188 DNA Mycobacterium tuberculosis 272 tccgtactgg tcgggtacgc ttcggtcgca gtgtgcgagt gatagatgac gaccgggacc 60 tcgtcggcat cttccatagc ccgccacacc ttcagttgct caccggaatc caaccggtag 120 aaggtcggcg agcgctcggc attggtcatc gggatatgcc gctcgggacg gtcagaacct 180 cgggtccg 188 273 158 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 273 gttctcgcac gatttcggat tagcgggatg gtctcaattg ggtatgcggg gaaggcgctg 60 acattcgccg cgattagctg tttgatggac cgggggtgat ttttgatcac ggaaatgggt 120 gtttatncag gtcgcacgct ttcatccggg gcggaacg 158 274 237 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 274 gggtgtgcct gctgtgtatg cacggcatac ggacatcctt cccctgaaga cccgcggtcg 60 aacagccacg tgtccatcat canggggtca accccggcca agggcgacgg cacgccaagt 120 tcgccgaccg ttaacctagt gctgttagct tcatttgctg cgagcaaaac agctggtcgg 180 ncgttaggaa tgaattgaaa ctcaaccgat ttggtgccgc cgtaggtgtc ctggctg 237 275 262 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 275 actacccggc caacggtgat ntcttggccg ccgctgacng cgcgaacgac gccagcgacc 60 acattcagca gatggccagc gcgtgccggg ccacgangtt ggtgctcggc ggctactccc 120 anggtgcggn cgtgatcgac atcntcaccg ccgcaccact gcccggcctc gggttcacca 180 gccgttgccg cccgcagcgg acgatcacat cgcttttatt tnntnttcng gaatccctcg 240 ggccgcgctg gcgggctgat ga 262 276 222 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 276 acgtcgggan actgttcgcg ttcatcctcg tctcggcgga ttggtctgct gcgccggacc 60 gaccgatctt cagcgggggg tcacgctccg tggggtgccg ttacttccga tcgcccagtg 120 tgcgcgtgct gtggctgatg ctgaacctca ccgcgttgan ttggatcggt tcgggatctg 180 gctggtggcc ggaacgcnat ttatgtcgct acgggcgccg gc 222 277 166 DNA Mycobacterium tuberculosis 277 gctcaaaggc actactggca ccaaggccca cacgtcacct gtgactcctg cgccgacccg 60 cccgaggtct ggccgttaca ccgaacgggc gagccgggag ttggtaccat cgaacaagac 120 aaggtgcatg ggcggagttg ttccgccact tcgtcgatga cgggtc 166 278 330 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 278 cgataccggc tgcttaccga gacatccacc atgccacccg aatcaccgca cgcgccgaaa 60 tcgcacaaca gcttgacgcc ttgcaggttc cgcgattgga attgccgacg gtctctgacg 120 gcgtcgacct tggcagcctc tacgagctct cggaatcact tgcccagcag ggggttcgat 180 gagtgtcaca ccgaagacct cgatatgggc gcaatcctgg ccgacacatc caaccgggtg 240 gttgtgtgct gcggcgccgg tggggtcngc aanacactac cgcggccgcg ctggcgttgc 300 gcgcggccga atatggccgc actgtggtcg 330 279 332 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 279 cgtcgtcgtc gtggtatgcg atagccatcc cgtcgggcta ctcgccatca ccgatcagct 60 tcgccccgaa gccgccgcgg cgatttccgc tgcgaccaaa ctgaccgggg ccaaaccggt 120 attgcttacc ggcgacaacc gggccaccgc cgatcggctc ggtgtacang ttggcatcga 180 cgacgtacgg gccgggctac tgccgacgac aangtcgcag ccgtgcngcn gctgcaagct 240 ggaggtgcca gattgaccgt ggtcggtgac ggtatcaacg acctccggcc ttagcggccg 300 cgcatgtcgc atcgccatgg gcagcgcccg ac 332 280 222 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 280 gcacgcaatc gaagtcaccc aaaccgggcg ggccaggcgt ctnacgccac gtcnaccagc 60 cgcaacctca acccggccac ggcgagctcc tgatcaaggc cgaggccatc ggtgtctact 120 tcatcgacac ctacttccgc tccgggcaat atccgcgcga actcccgttc gtcatctgct 180 ccgaagtatg cggcacggtg gangccgtcg gccaggggtt ac 222 281 184 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 281 tcgactgtgt ggccacagat cacgccccgc atgccgagca cgagaaatgc gtcgaattcg 60 ccgcgggccg gccggcatgc tcgggttgca gacggcattg tcggtggtgg tgcatacaat 120 ggtggcgccg gcttgttgan ttnggcgcga tatcgcgcgg gtgatgagtg anaaccggcg 180 tgca 184 282 409 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 282 gaacctgaca ccctggtcac gggtgagcac ggacttgatt tcttcnctat tggtcggcgc 60 tgttgagcac accacgccgc tgacggccgt cgcgtcctcg ctgtgctcgg tctggtggag 120 cgcgctgccc gcggccnaac atcntaaatc aagcgtattc gtcaacagat atcatcaatg 180 tcggcgctgg actattcaaa tcatcgatat actggtgacc tggtccttcg ccatcgatca 240 atggcgatag tcacgcaaat cgtcacggac atcgtcggcg tcccagctgg cccgtgccaa 300 cagatgctgc aacccatcgg ggtggtatca ccgcggtgct cggcgatggt ccacaattct 360 tgcggtccaa gcccnaaaca tcccgggcat gaattcaccg gcatgcgcn 409 283 413 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 283 ctatcgtacc cgcgccggtc accttctgga tatcgccggc ctggtcaagg gggcgtccga 60 gggagccggg ctgggtnaca agttcctggc tcatatccgc gaatgcgacg ccatttgtca 120 ggtggtgcgg gtgttcgtcg acgacgacgt gactcatgtc accggacggg tcgatcccca 180 gtccgacatt gaggtcgtcg agaccgagct gatcctggca gatctgcaaa ccctggagcg 240 ggccacgggc cggctggaga atgaagcgcg caccaacaag gcgcgcaagc cggtctacga 300 agcggcactg cgtgcccagc angtgctcga cgccgggcaa gacgctgttc gccgcggggg 360 tggatgccgc cgcgttgcgc gactgaaact gctgaccacc aagcccttcc tgt 413 284 283 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 284 tactcaagct tcaggccgcc acgtccgccg tccgtcggcg acgtgacctc gagcgccgag 60 ttcgactcga catcgccgcc ggcgcatgcc gacatgaacg cggcactcac cgcaagcccg 120 tcggacgtca ggtcgatcga ctccgcttca agcaccggat cgtccgggca actcgcggcc 180 tcggcctgtg cgaacggcac acccgtcgtg gcggcncccc gcgcggaact gggctcatca 240 cggtcgttgc gagccggtcg cgtcaccgcg taccgacgcc gtc 283 285 397 DNA Mycobacterium tuberculosis 285 ccgacatcga gtgggctcgc agtgacttgg cgacctccaa gccaccggta cccgccgcgc 60 ggcaagccaa ggacgacgac ggccttgccg gatagctgcg ccaggcgttg cgccaactgg 120 cgtccagcgt cgccacgatc gtcaaagagc ttcatctgcc gagtgtgtcg ccatctcatg 180 gctccaaata tggaattagg tccctgggcc gactgacgac agtccctcag cgaccggatt 240 gcgcatcccg ccttgtacgc tactccgcaa atcccgggct tgcgtccgcg gaagcgaact 300 cggcggcgct acgtggtggt tcacttcggc cgtgcgcact cggatcgacg ggccgatggt 360 ggccgggccc gcgcgcttct tggtcatccg attgagt 397 286 342 DNA Mycobacterium tuberculosis 286 atactcaagc ttgtcgcggt aaaccgcacg cagggcggtg ggtgcggtgt caaagacacc 60 cacacttctt tgcggttcgg tgatctcgac accggccgcg agccgaccac catgcgcgcg 120 tagatcggcg atcagcgcgt cggctatcgc ctgggtgccg cccaccggaa tcggccagcc 180 gaccgaatgg gccagcgttg ccagcatcag tccggcgccg gccgacacca gtgacggcaa 240 cggtgaaatc gcgtgggcgg caacgccggt gaacaacgcg cgggcatcct cgcccgccaa 300 cgaccgccag gcagggtgcc tgggccatca tccgcagccc ga 342 287 430 DNA Mycobacterium tuberculosis 287 tggactcata acgatcgggt cagcgacgcg ccaacacgaa cggccggacg agtgggccag 60 ggtcgcgcct cccctacaaa caggatccgt tgcctgcgag cgacaggctc cggtgcggcg 120 ttgggcgccg tgctcgtccc agcgtccggt cccgggtcgc cggcgacgct tgtttcctcc 180 atactcgccc cctaatctcg aggcagcccg tacccgcagg caacctccca aaaatgcaat 240 cccccaaaat gcaatgcgtc gagctatttc tcacaccgac cgctagttgc ggatcagaaa 300 tccgttgggc gcggaagtcc agccgaattt gttctcccgc tccgcatcat gcttgtaatc 360 gtttggaaat catcctcata tgcctcgatc gcttcatagg tcaagcccaa acccggcagg 420 atgggtggcc 430 288 473 DNA Mycobacterium tuberculosis 288 ctttacactt tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc 60 acacaggaaa cagctatgac catgattacg ccaagctatt taggtgacac tatagaatac 120 tcaagcttag tggttgcgca cgtaaattcg tcaggtgacc gatcccctgc tgtctcactc 180 gcctcacagc gaccaccacg gctggcgctc aaggcgggca cgtgcggagc agatgaggaa 240 tgtgcgacgt cttgatgcag cctgtcagaa caccgagacc ctcgacgaac ttacgatcga 300 aaccgcttag gccaaccggt gacgggggtg tctttccgcg gctagggcgc cttatcgtcc 360 gaaggccgtg ggtggtgatc gccttctggg tcgcgcttgc gggtctgctt gcgccgacgg 420 tgccgtccct ggaccgatct cccagcggca tccagtggcg attctgccat cgg 473 289 418 DNA Mycobacterium tuberculosis 289 caggcatgca agcttgcgat gtatcaacac gccgttgcgc agcgtgagcc gatagttgac 60 atccggctcg gtgaaggtga aatcgatggc caggtcgagg tcccatgcgc gtgggccatt 120 gatgctgatc gccaggacgt caaagatttg gtccggcgtc agctgggcga aaaacgtggg 180 cgccgggact tgcccggagc tgcccgggtt cccgtcgcgc agctcggcgg ccccggtcag 240 aaagaaattg cgccaggtcg cacactccgc gccgtaggcc agctgctcca cggtgtcggc 300 atatagcccg cgggccgcag cgtgctcgct gtcggcgaac accgcatggt cgagaagcgt 360 tgccgcccaa cggaaatcac tgcgtcaaag cttcgccggg ccactccagc actccgtc 418 290 194 DNA Mycobacterium tuberculosis 290 atactcaagc ttgaccgacg ctgatcgcac cgcacgcggg aacctcaagg gcactactgg 60 cacaagggcc cacacgtcaa cctgttaact cctgcgccga ccccggccga agtccttggc 120 gttaacaccg aacgggccaa cccgggaatt tgggttccat caaaacaaat agcaggtgcc 180 tgggcggagt gttc 194 291 166 DNA Mycobacterium tuberculosis 291 gtcgtcgtgt gctggggcgt ccgtatcagc acgcccacga aatggggcac aagaaggatt 60 cctggaacgg tggctgtcca agatcaccct cgcccaaaac tgctacgggc acttctacat 120 cgagcacaac cgtggccatc acgtccgcgg tgtccacacc gggagg 166 292 291 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 292 atatgccttg ctgagctttt cggatcgcag cgagtcgtac ccgcgccggt caccttcgtg 60 gatatcgccg gcctggtcaa gggggcgtcc gagggagccg ggctgggtaa caagttcctg 120 gctcatatcc gcgaatgcga cgccatttgt caggtggtgc gggtgttcgt cgacaacgac 180 gtgactcatg tcaccggacg ggtcgatccc cagtccgaca ttgaggtcgt cgagaccgag 240 ctgatcctgg cagatctgca agccctggag cgggccacgg ggcggctnga a 291 293 442 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 293 gacaccctgg tcacgggtga gcaggactcg atttcttcgc tattggtcgg cgctgttgag 60 gcacagcacg ccgctgaggc cgtcgcgtcc tcgctgtgct cggtctggtg gagcgcgctg 120 cccgcggccg aacatcgtaa atcaagcgta ttcgtcaaca gatatcatca atgtcggcgc 180 tggactattc aaatcatcga tatactggtg acctggtcct tcgccatcga tcaatggcga 240 tagtcacgca gatcgtcacg gacatcgtct gcgtcccagc tggcccgtgc caacagatgc 300 tgcaacccat cggggtggta tcnccgcggt gctcggcgat ggtccaacaa ttcttgcggt 360 ccaagcccga aaccatccgg ccatgagttc accggcatgg cgcaacggct ggtgccgggc 420 aaaacgcggc gcgatcgaat tc 442 294 150 DNA Mycobacterium tuberculosis 294 tgtagaaggt gggtcccgtc caacttcgcg gcggcggcgc gatatgcctt gctggtcttg 60 ctcatttgat atccaatcta tgggtcgtgg ttactcaacg ggccgaagct ggccctccca 120 cgggtagggt cctattcgac ggtgatgtcc 150 295 321 DNA Mycobacterium tuberculosis 295 cccgaatccg gtggccggca gggggcctgg cgacgtggac accttctaac ttgtctttac 60 cggtcactgt tgcaccccaa cacctttaac gacgtggacg gacgttacat cggattcgac 120 ggtgtcatcc acagcgttgc cattgggcac acccactacg ccaatttctc cgactgggac 180 acctaccgca gcctcgcccc actgcaggga ctgttgttcc cgcaacgggc catcgacatg 240 atccagtcgt tggtgaccga cgcggagcag actggtgcgt atccgcgttg ggcgctggcg 300 aaattccgcc accggcatga t 321 296 184 DNA Mycobacterium tuberculosis 296 ttgagatgct ggtcgggatg ccgatggttg gaacatggtc ccctggcgtc gaatacgcgc 60 gagcgcatga gctcaccggt tcggaacaac gtatcgaaga actcgcactg ctggcagatg 120 gtatctccga tgtggttgta atttgtatcc caactctaac tgtgctatcg gatctgcgtg 180 aata 184 297 259 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 297 cgtaatcacg atcccgctga gacacttgac cttacggccg aagtgacttc gctgctgcta 60 tgccgacacc cgatttccat acgctgctgt acacgacggc cgggccggtg gcctccatca 120 cgctcaaccg cccggaacag ctcaacacca tcgtcccgcc catgcccgac gagatcgagg 180 ccgctatcgg gttggtcgaa cgcgaccagg acatcaaggt catcntnctg cgcggtggcg 240 ggcgcgcctt ctccggcgg 259 298 369 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 298 caagcttaag ctggttccgg ccactccatg agccgtagtg caatggttcg tgcacggcga 60 ggccgaactt gccataaaca tccctgacga aagtctccgg caagccgatt gcttcttcgg 120 gccgcttctt gtggattgtc cgataacccg gtccctcatg ctggaagttg tgcgcactct 180 ttccttccgc gatgtgggct aacgactcgt cattgagcaa gaagtacgtg cacaggcatc 240 gtccgccggg cttcagcacg cgggagatct cgtccagata gtgctccacg tccggnggga 300 aacatgtggg tgaacaccga ggtnagaaac accncatcca acgacgcatc cgggatatgg 360 aaagcgaaa 369 299 387 DNA Mycobacterium tuberculosis 299 tatggtcttc gtcgaccagt acgtcgtagg cgccatgagc cagcgactga agccgcgcca 60 tgcctgcacg gcccgctcat ccagcgaggc ggccatctcc cgcagatagc ctgccgcctc 120 ggcgcgcacg ctgtccggat cgcgtccgag ctcgtcggcc agcgcacgca gccgctcgtc 180 ataccatcgg gcatccagca gttgggtaac ctcaacgggg tcggtcgcta gcggcgtcat 240 tgattcagca acaataccga tgcgctgcag caactttcgc agtccgatgc ggcccacctc 300 ccgtgcagtc actggctagc ccccgtcatg ccggttgtgt cgatggcacg gcagcgggct 360 cgtaaacctg cggtctcagc tcgctgg 387 300 73 DNA Mycobacterium tuberculosis 300 gcttagcggt cttgctcgaa ccgacattgc gtgccactca tgagcgggtg gcggtcgcgg 60 tgcttacaca tct 73 301 156 DNA Mycobacterium tuberculosis 301 gtatctggcg cctctcgaat atccttgaac gtcccgcggt gccacccaga tagatcgcag 60 cgccctgcaa tggagttccc tttatggcct ctctagcctc ccgcttgatc ggctcgaccc 120 gagagatgcc ctcgggcgtt gcgggatctc cctcca 156 302 394 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 302 cttcacgccg atccgcgacc gcgaacgcga cggtgacggt gggcgacaag gttcggttgg 60 tcgccgcggc gctgggcgat atcagctcac ccggtttcga ggtgttcggc gaccggacgg 120 tgctgcagac attcttgagc gtcctcgacc ggcccgattc ggccttcaac atcgtgacgc 180 cgtatttcgg cggtaccgct cggcgccgag tcgaaggcgg cctgagctaa agccgggcat 240 tgcgcgagtg gtaaacaagt tcggtgactt cggttgaccg actcgacggg ctcgatctgg 300 gcgcgctgga ccggtatctg cgttcgctgg ggatcgggcc naccgcnant tgcgttgcga 360 nctgattccg gtggagctcc aatctgactt ccgg 394 303 404 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 303 gcagctaccg accctagcga cgagtgtgtt cgcagcgtcg aatgtgaacg ttcggcgtga 60 ttcggcgcgc gggttcccgc tctcagcgca cgttcggcgc cgaggnggct agtccctggt 120 taagcaatgt ctcggtcgcc gccagcagcg cgcatgtcgc caacccgtcn accgcgttgc 180 gcatgtccgg taccgacgga aacgacggcg cgatccggat gttcttgtcg tccggatcct 240 ttcgatacgg gaacgacccc ccgcctcggt caccgcgata ccaacgtcct tagccaangc 300 tacngtccgg cgcgcggtcc cgggcaacac gtcgaagctg atgaantaac cacccttggg 360 ctcggtccaa gangcgatct tggactcctt aaccgctgat ncaa 404 304 479 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 304 tccccatcgg cgccggaccg tttgaaagtc caagcacggg tgggatggaa tcgacgacag 60 ttgagcgccg tcggtggccg tggtcagcag ctgttcgcga acgcaccagg tcacatccct 120 tcgacatctc accgacgtgg cacgggcgac atcaacagga agattgacga atccctcgca 180 ggcgcggcac gtccgcaggc caacgccaac tacggggcca ccagcgatcc tccgctcacg 240 caccagccca agccaggctc anccacccaa gtcggcccgc gctctccctc gccccctggt 300 ctccggggcc ttgttaaaca actaccggaa gtccaccaat cctcgctgca tctcgacacc 360 gtccgcctca ctcccttcct cccgcccctc tccacacnac acacctcttg cattaaggtc 420 acggagcggt cacttttcgt cggacgaaat tcgcaatccg gccgctcgcc gccagagat 479 305 260 DNA Mycobacterium tuberculosis 305 cggaaagtgg atactcccag caggtagcag gtcgccacca cgctggtcag tgcgcgttca 60 gctcgcttgc ggcgctgcag cagccagtcc gggaaatagc tgccctggcg cagcttgggg 120 atcgcgacgt cgatggttgc ggcacgggtg tcgcaaatca cggtggcggt agccgttgcg 180 ctgattggac cgctcatcgc tgcgttcgcg gtagcccgcc ccgcacaggg cgtcggcttc 240 agcccccatc aaggcggcga 260 306 464 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 306 ggccgagtcc agcacttcgc actatgtgca gaccaaanac ccggtggtcg ccgcgctgcg 60 gcagcggctg gcaacggcgc cggtgatcac cgagtggtgc gnagttgccg accggcagtt 120 cgccgcgggc ttactacgag aagggcctgc gcgacgtcat caggtatcac gtgtcgatga 180 cgtcgagcgt taacttcccc gaccagacgg cgacctcgcc gatggacccc gcgttgtacc 240 tggtgtgggc gcaagctaac gccgccgcan gctatcggta ctcggtcgaa gcgcagccgg 300 ggtcgcaagc gctagcgggc aaggtcgcga cgatctcggt cacctggacc aactacggcg 360 ctgctgccgc caccgaatag tgngtgcccg gctaccggct ggtggattcc acgggacatg 420 tggttcggac ctgccggcag cggtggaact gaagangctg gtct 464 307 315 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 307 agcttcaagg acatcgtcat cgcgaccaaa accgcgagct aggtcggcat ccgggaagca 60 tcgcgacacc gtggcgccga gcgccgctgc cggcaggccg attaggcggg cagattagcc 120 cgccgcggct cccggctccg attacggcgc cccgaatggc gtcaccggct ggtaaccacg 180 cttgcgcgcc tgggcggcgg cctgccggat caggtggtat atgccgacaa agcctgcgtg 240 atcggtcatc accaacggtg acagcagccg gttgtgcacc atcgcnaacg ccaccccggt 300 ctccgggtct gtcan 315 308 331 DNA Mycobacterium tuberculosis 308 gctcgcggtc cagcagcaga cgtgtctgac cccgacgccc ggccgccggt accgaaaccg 60 gatcggcccg ccgatggccg cggccacggc gtctgcctta cccggcccgg ataccagcag 120 ccacacctcg cgggaacgct gaatcgccgg cagggtcaag gtgattcggc gtggcggcgg 180 tttcgcgaat cgtccaccgc caccaccatg cgggtgctct cgaagacgcg gggctgtgcg 240 ggaacagcga gttaatgtgg ccctcgggcc ccatgcccag caggtggacg tcgaaattcg 300 gcccgggtca cctggtgcgg cactggcggc c 331 309 286 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 309 agcttgtcga tcgtccggca gcgtccggcg agtcaagtcg aagccagtcc ggtctcctct 60 ccgactacgg ccaagaactg ggcgacggtg tcagtgcata ccagcggana ctggtggcgc 120 cctaggcgag cgaccgcctc acaaacggcg gtgaccgcgt tctggtcgtg caccatcgag 180 ccgtgcccat cccggccgcg tgccgtcagc cgcatccact ggatgccctt ctcggcggtt 240 tcaatcaggt acaggcgacg ttcgccanca tcgtgccggg gcangg 286 310 331 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 310 ttggtgatca tcgncccaac gaccccgagg cgatgttctt gcacaccgag gagtgtcgca 60 agctggggct ggccttcgcc gccgatccgt ctcagcagct ggcgaagctg tcggggtgag 120 gaaattcgca ggctcgtcaa cggtgctgct tacttgttca ccaacgacta ctaatgggat 180 ctgctgctgt ccaagaccgg ctggtcagan gccgatgtga tggcgcagat cgacctgcgg 240 gtgaccacat tgggtcctaa gggtgtcgat ttggtagaac ctgacgcacc accatccacg 300 tcggcgttgg tccccgaaac agccagaccg a 331 311 458 DNA Mycobacterium tuberculosis 311 ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga 60 ccatgattac gccaagctat ttaggtgaca ctatagaata ctcaagcttg attttgatca 120 tcatgatgat catcacccga agtgtggtag ccgcagtggt tatcgtgggt accgtcgtgc 180 tttccatggg cgcctctttc gggctttccg tattggtctg gcaggacatt ctgggtatcg 240 agttgtactg gatggtgttg gcgatgtcgg tgatcctgct cctggcggtg ggatccgact 300 acaatctgct gctgatttcc cggttgaaag aggaaattgg ggccggattg aacaccggaa 360 ttatccgtgc catggctggt accgggggag tggtgacggc tgccggcatg gtgttcgccg 420 ttaccatgtc gttgtttgtg ttcagcgatt tgcgaatt 458 312 289 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 312 caggcatgca agcttggcgt gccgttccaa cccgaattgg ctttcggcgc catcggtgag 60 gacggcgtgc gggtgctcaa cgacgacgtc gtccgcggga cacacctcga tgctgccgcc 120 atggacgcgg tcgaacgcaa gcagctgatc gagctacaac gccgcgcgga acgcttccgc 180 cgcgggcgtg accgcatccc gttgaccggg cggatcgcgg tgatcgtcga tgacggcatc 240 gccaccggag cgacggccaa ggcggcgtgc caggtcnccc gggcgcacg 289 313 154 DNA Mycobacterium tuberculosis 313 ggcatcttgg ccgccatgtt agccacactg ccaccggcta tagaagcgat gcgcaccgtc 60 ctgccagcac attgcggcgc tcctccctgg aaagcaagat aaccaagctc atgccgtggt 120 tgtgggtggc gtggtttggt ttgggtaact ttgg 154 314 324 DNA Mycobacterium tuberculosis 314 tcggctaata atcgtcgacg ccggcctcct ctgcaatcgc cttggcggtc gccgggttgt 60 caccggtgat catcacggtg cggatgctca ttcggcgcat ttcgtcgaat cgttcccgta 120 tgcccacctt gacgatgtcc ttcagatgga cgacgccgat ggcccgcgcg ctgctgttat 180 cggtccattc cgcaacgact aggggtgtcc cccgccggag ctgatgccgt cgacaatggc 240 acccacctcc tcggtggggt gggcaccgtg atcgcgaacc cacttcatca ccgcagccgc 300 ggcaccttgc ggattcgacg gatg 324 315 322 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 315 ctcaagcttg gaggcgtggc gatcgcggtc caaggcgcgc tctccgagca caacgagcga 60 agacngctcg gcgacggagc ctttatcgac ntccgttcgg gctggctgac ggcggcnaaa 120 taatgctgga ctcgttgttg tcgacggtgc cgtggcgagc cgagcgccgt cagatgtacg 180 accgggtggt ctatgtgccg cggttggtga gtttccacga cctgaccatc gaagatccgc 240 cgcatccgct gctggcgcgg atgcgccggt ggctcaacta attctacggc ggcgaactgg 300 gtnatccctt cnccaccgtc gg 322 316 404 DNA Mycobacterium tuberculosis 316 cctaggtcaa ccgtaccgtc atcggatcgg ggtcgaccgc acagatggac tggagcttcg 60 gcgaggtcat cgcctatgcc tcgcgggggg tgacgctgac cccgggtgac gtgttcggct 120 cgggcacggt gcccacctgc acgctcgtcg aagcacctca ggccaccgga aatcattccc 180 gggctggctg cacgactgcg acgtggtcac cctccaggtc gaagggctgg gcgagacgat 240 gcagaccgtc cggacgagcg gcactccttt tccgttggct cttcggccga atccggacgc 300 cgaacccgac cggcgcgggg tcaacccggc accgacgcgg gtgccgttta cccgcgggct 360 gcacaaatcc cgacgggtat gggctttgac ctgccgacgg ggga 404 317 346 DNA Mycobacterium tuberculosis 317 agcttggcgt gacaccaaca cagggcactt aagatggcaa tgcgccgcct acctgcacgt 60 tttcgcgatg tcagaggatg ccgaggggag aacaatgcga gcacggccgc tgacgttgct 120 caccgctttg gcggcggtga cattggtggt ggttgcgggc tgcgaggccc gagtctaggc 180 cgaagcatat agcgcggccg accgcatttc gtctcgaccg caagcgcgac ctcagccgca 240 gccggtggag ctactgctgc gcgccatcac gccgcctagg gctccggcgg cgtcgccgaa 300 cgtcgggttt ggcgaactgc ctacccgggt ccggcaggca accgat 346 318 333 DNA Mycobacterium tuberculosis 318 tcatgccgtt ggaccgacca tcggagttag ttgccgaacc gcgggaccac cgcaagcacc 60 cggtcctggt cgcgcaccgc gtcggccaac cgcttgagca ccaccacgcc gcagccctcg 120 ccgcgcacga atccatccgc gttggcgtcg aagctgttgc atcggccggt cggtgacagc 180 gccgaccact tggacagcgc gatggcggtg aacggtgaca aggtgagctg caccccgccc 240 gccaatgcca cgtcggtttc acgcaggcga agctctgaca cgccaagtga attgccacca 300 gcgacgacga acaagcggta tctacggcga tgg 333 319 207 DNA Mycobacterium tuberculosis 319 gggtcgactt tctgcaaggc gaggctacac cgtcgtcgtc gtggtatgcg atagccatcc 60 cgtcgggcta ctcgccatca ccgatcagct tcgccccgaa gccgccgtgg tgatttccgc 120 tgcgaccaaa ctgaacgggg ccaaaccggt attgcttacc ggcgacaacc gggccaccgc 180 cgatcggctc ggtgttcagg ttggcat 207 320 250 DNA Mycobacterium tuberculosis 320 aatccgaaat cctgaccgat acttgaacct ggtctcgttc ggcaataact cgtcggcgtg 60 caggacgcgg cgcaaacgta cttcggcatc aacgcgtccg acctgaattg gcagcaagcg 120 gcgctgctgg ccggcatggt gcaatctaac agcacgctct tcccgtacac caaccccgac 180 ggcgcgctgg cccgggcgga acgtggtcct cgacaccatg atcgaaaaac cttcccgggg 240 aggcggatgc 250 321 365 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 321 ttccgaattt cgggtccngg tcatatgacc ctcatggaag aagaagcggc cgccccgcgc 60 ccgtgcgacg gcgaatgaaa accctcaccc aggccgcatt gaacgccgac aagacggtgg 120 agcaggtcga agacgtcctg gacggtctgg gtaagaccat ggccgagctg aacagctcgc 180 tgtcacagct gaacagcacc gtggagcgct tggaggacgg tctggaccat ctcgaaggta 240 ccctgcacag cctggacgat ctcgcgaaac ggctcatcgt gttggtcgag ccggtggaag 300 ccatcgtcga tcggatcgac tacatcgtga gcctcggcga aacggtgatg tcaccgctgt 360 cggtc 365 322 413 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 322 nctcgatctt ggggtacgtt cgatgaggct gctgaccaac aacccggcca agcgggtggg 60 actggatgga tacggattgc acatcatcga gcgcgtgccg ctgccggtgc gggccaacgc 120 ggaagaacat ccgttacctg atgaccaagc gtgacaaatt ggggcacgac ttggctgggt 180 tggacgattt tcacgaatcc gtgcatctgc ccggagaatt cggcggtgcc ttgtgaaggt 240 ggcgccgggg tgccggatct gccgtcgctg gatcgtctgg tgtgcggctg gcgattgtcg 300 ccagcagctg gcacggaaag atctgcgacg cgctgttgga cggcgcccgc aagtggccgc 360 cgggtgtggc ctcgatgacc gactgtggtt cgggtgctcc gcgcgatcga tat 413 323 364 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 323 tcatcccgac caaaacgcga gctaggtcgg catccgggaa gcatcgcgac accgtggcgc 60 cgagcgcgct gccggcaggc cgattaggcg ggcatattat cccgccgcgg ctcccggctc 120 cgagtacggc gccccgaatg gcgtcaccgg ctggtaaccg ctcttgcgcg cctgggcggc 180 ggcctgccgg atcaggtggt agatgccnac aaagcctgcg tgatcggtca tcaccaacgg 240 tgacagcagc cggttgtgca ccaagcgcga acgccacccc ggtctccggg tctgtccaac 300 cgatcgaccg cccaagccca catgaacaaa ccccggcatc acgttgccga tcggcatacc 360 gtga 364 324 488 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 324 ttggcgggtt ggcccagcag cccgccggtg acggcgacga tgctgggctg gttgcggccc 60 tgcgccaccg cggcttgcat gctggttggc tgtcttggga cgatcccgaa atagtccacg 120 cggatctggt gattttgcgg gctacccgcg attaccccgc gcggctcgac gagtttttgg 180 cctggactac ccgcgtggcc aatctgctga actcgcggcc ggtggtggcc tggaatgtcg 240 agcgccgtta cctacgtgac ctgatggatc ggggggtgcc gaccgtgccc ggcgatgtgt 300 atgtgccggg anagccggtc cggttgccac gcaaaggcca tgtcttcgtc ggtccgacca 360 tcggtaccgg gacacggcgc tgtattgccc ggttcgctgc cgagttcgtc gcgcaactgc 420 acgcnggcgg gccagcggtg ctcgttcanc ccggaggttc cggtgacgat gatcgtgttg 480 gtctccct 488 325 396 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 325 gtaggagaga acaaagaccg tcgataggac acgtgttacg ccggtagctg tcattggtat 60 ggggtgccgc tgccgggggg catctactca cccgatcggt tgtgggaggc gttgctgcgg 120 ggcgacaatc tggtcaccga gatccccgcc gaccgctggg acatctacga gtactacgac 180 cccgaacccg gcgtgcccgg acgcaccgac tgcaaatggg gcgcgtacct cgataacgtc 240 ggcgactttg atcccgagtt cttcgggatc ggggagaaag aaacgatagc gatcgatccg 300 cagcaccgct tgttgctgga aacctcctgg gaagccatgg aacacggcgg gctaacaccg 360 aaccatatgc ctcccgacan gggttttcgt ggggtt 396 326 394 DNA Mycobacterium tuberculosis 326 cgaactgagc ccatagaaag gcagcgacta attcgctggg caaataggaa gaccctttgt 60 cctgccacgt atatttgtcg acctcgttgc gaaggaagcg gctgcgattg gtgccctttt 120 ccctggagaa tctctgcccg gagcaggaag tcttatgagt tgacaagcag gggcgccgcc 180 ttcgccggaa atcacattct tggtctcgtg aaatgagagc gctcccaggt cgccgatgct 240 gccgagcgcc cgcccacgat acgacgccat cgcgccttgg gccgcgtctt cgaccaccgc 300 caggttgtgg tgcgtggcga tcttcatgat cgcgtccatc tcgcaggcca cccggcatag 360 tgaacgggga ccatggcctc ggttcgcggg tgaa 394 327 140 DNA Mycobacterium tuberculosis 327 cttagacgcc acctccgggc cgagctccac ggggtggata agtacggccg gatgtggccg 60 caatgggaag ttgttgcccg cttgactgtc cgggttaacg ccggattcca ccacatcccc 120 ttgcgaaagg ccgttgggtt 140 328 242 DNA Mycobacterium tuberculosis 328 gatcgcgatc gtcgatgtgg ccatccggct tggcgtcgac ccgcgtaagg cagaccagat 60 ggttcgcggc acggtcaacc tgccacacgc actggtaaga ctgcccgcgt cgcggtattc 120 gcggttggtg aaaaggccga tgctgccgtt gccgcggggg ctgatgctgt cggatcgacg 180 atctgatcga gaggatcagg gcggctggct ggaattcgat gccgcgatcg cgataccgga 240 tt 242 329 220 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 329 agcttacgcc gctttcgctt cngatttggg acgccgcatc gaaagcgcag ttggaagcgc 60 ggcgcccggc tggtcgagct gctcaagcag ccgcaatccc agcccatgcc cgttgaggag 120 caagtggttt cgatcttcct gggcaccggc ggtcacctgg actcggtgcc cgtcaaggat 180 gtcggcggtt cgaaaccgaa ttactggacc acatgcgggc 220 330 328 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 330 cgacgggacc tcgtcgcatc ttccatagcc cgccacacct tcagttgctc accggaatcc 60 aaccggtata aggtcggcga agcgctcggc attggtcatc gggatatgcc gctcgggacg 120 gtcagatgcc ctcgggtccn gccagcactc ctcaggcttc gtcggggtgg tcgcgaccgc 180 atgggccaca tcgcattcac caggtctgcg cgaatcacca gcacgtanac ggttcctttc 240 ctaagcaaca ccgaaatttc aggacccgaa tgctccggga aaacatgtca cggtaagtcc 300 ggtattccgg gtaccggttg agcattga 328 331 366 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 331 cggcatcggt ttgggctgtc accagcagtt ggtagttctt cactactgtt gttcgagcgt 60 cgagccgccg cgcgtgtcga ggtcgccgga cgcgtacccg ccaggccggt cagggtgccc 120 ttccagtcca cgcngctgtg gtcggctaac cgcttatctt caatcgagac natcgccagc 180 ttcatcgtgt tggcgatctt gtccgagggc acctcgaacc ggcgctgcga ntacagccac 240 gcgatcgtgt tgcccttcgc gtcgaccatc gtcgataccg caggcacttg cccctcgagc 300 agctgggccg atccgttggc aacgacctca gaggcacgat tggacatcag ccctagcccg 360 cctgcg 366 332 407 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 332 ccgtcgangc cgccgacttg gcttgaccga caccaacatg gcctgagggt gttcaacaag 60 accgtggccg acgggctgaa catcaccatg agcggcatga gccacgccac cgagttcatc 120 atgttgatcg ccgaaaacca ttggcgggta gcggaagaac ggtcgaggtg ctctacaccg 180 agtattcgaa gtcgaaaggc caaccgctgc tcaacggcgt caacatcatt ttcgacgggt 240 ttctgcgagg gaggatgcca cgatgaactg gatccaggtg ctgttgatcg cgtcgatcat 300 cgggttgctg ttctacctgt tgcggtcgcg ccgaagcgcg cggtccgtgc ctgggtcaag 360 gtgggctatg tcttgttcgt gctcccggca tctatgccgt gctgaga 407 333 473 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 333 ttacacgncc tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac 60 acaggaaaca gctatgacca tgattacgcc aagctattta ggtgacacta tagaatactc 120 aagctttttg agcgtcgcgc ggggcagctt cgccggcaat tctactagcg agaagtctgg 180 cccgatncgg atctgaccga agtcgctgcg gtgcagccca ccctcattgg cgatggcgcc 240 gacnatggcg cctggaccga tcttgtgccg cttgccgacg gngacgcggt angtggtcaa 300 gtccggtcta cncttgggcc tttgcggacg gtcccgacgc tggtcgcggt tgcgccgcgg 360 aaagcggcgg gtcgggtgcc atcaggaatg cctcaccgcc gcggcactgn acggccagtg 420 ccgcggcgat gtcngccatc gggacatcat gctcgcgttc atactcctcg acc 473 334 305 DNA Mycobacterium tuberculosis 334 caggcatgca agctttgtca caccaagtgt ttcgaccagg cgctccatcc ggcgagtgga 60 tactcccagc aggtagcagg tcgccaccac gctggtcagt gcgcgttcag ctcgcttgcg 120 gcgctgcagc agccagtccg ggaaatagct gccctggcgc agcttgggga tcgcgacgtc 180 gatggttgcg gcacgggtgt cgaaatcacg gtggcggtag ccgttgcgct gattggaccg 240 ctcatcgctg cgttcgcggt agcccgcccc gcacagggcg tcggcttcag cccccatcaa 300 ggcgg 305 335 432 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 335 agcttagcca gtttttctac tcttgggccc acacccacag tgcttcgacg gtacggtcac 60 ccatgatggc catccagttg gcatcggtga gctgataaat gccagctggt ttcgccaacc 120 cggtagcgat cttggcgcgc tgcttgttgt cactgatacc tatcgagcaa gacagcccgg 180 tttgcgacaa gatgactttt cggatctctt cggcgacttc gatggggtcg tcgggagtcc 240 cgggcgccac cgcgaggtaa gcctcgtccc agccccatac ctcgaccggg tatcccaggt 300 cgcgcaataa cgccaccacc tcctcggacg ccgcgttgta ggcggctggg ttcgacggca 360 agaagtggcc tcagggcatc gtcggcgcgg tcccaacggc ntgccggcgc gcacaccgta 420 ggcgcggggc tc 432 336 429 DNA Mycobacterium tuberculosis 336 ccggcggaac tcagacgtgc tggtggtgcg gcatggcacc gcgggcagca aagcgcactt 60 ctccggggac gacagcaagc gaccgctaga caagaggggt cgtgcgcagg cagaagcgtt 120 ggtaccacag ctgctggcgt tcggcgccac cgatgtttat gccgccgacc gggtgcgctg 180 ccaccagacg atggagccac tcgccgcgga actgaacgtg accatacaca acgagcccac 240 cctgaccgaa gagtcctacg ccaacaaccc caaacgcggc cgacaccgag tgctgcagat 300 cgtcgagcaa gtaggcacac ccgtgatctg cacgcagggc aaggtcattc ccgatctgat 360 cacgtggtgg tgcgagcgcg accgtgtgcc cccgacagtc ccgcaatcgc aaaggcagca 420 cgttggtgt 429 337 94 DNA Mycobacterium tuberculosis 337 gtatggtcag ctgtccatcc ggcgctgtcg gccgagctgc cagatctcgt cagccgtaac 60 cgggttgcgg gatccacgcg tgcgggttgt ctac 94 338 351 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 338 ccgactttcc gcgggtaccc gctcaacttt gtgtcnacct caacgccatt gccggcacct 60 actacgtgca ctccaactac ttcatcctga cgccggaaca aattgacgca gcggttccgc 120 tgaccaatac ggtcggtccc acgatgaccc agtactacat cattcgcacg gagaacctgc 180 cgctgctaga gccactgcga tcggtgccga tcgtggggaa cccactggcg aacctggttc 240 aaccaaactt gaaggtgatt gttaacctgg gctacgcgac ccggcctatg gttattcgac 300 ctcgccgccc aatgttgcga ctccgttcgg ttgttccaga angtcagccc g 351 339 152 DNA Mycobacterium tuberculosis 339 gcaccgatgt cggcgagcac ttcgtcaact tccaggggtg cccgcaccaa gtatttcgac 60 gagtatttcc gtcgggccgc cgccgccggt gcgcggcagg tggtcatcct ggcggcgggg 120 ctgggactcg cgcgcgtacc ggctgcctcg gc 152 340 263 DNA Mycobacterium tuberculosis 340 tgcacccaac ttactgagca tgctaacgct ggtcgtgcgg gtcttgttcc cgcgtgtcgg 60 cagggcacac gctcggggcg tagctgggag aggccccggt caagcccgga gagcagtgct 120 cagtccgcca gcttgaccga ctttcgatga gaacgcgctt ctcgccgtat tgaactggcg 180 tgctgacggt cgctgagcag cgctcgccga gtgcggccgc tgattctttc atcgagccag 240 gacgcgcatt cgtgttcggc cgc 263 341 249 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 341 agcttacggc cggtcgacgc gacgagtggt tcatgacacc acaaaccgtc aacgcctact 60 acaacccggg gatgaacgaa atcgtcttcc cgcagcgatt ttacagccac catttttcga 120 tccgcaggcc gacgaggccg ccaactacgg cgggatcggg gcgcgtgatc gggcacgatg 180 atcgggcacg gtttcgacga tagggcgcca aatacgangg cgacgcaatc tggtcnattg 240 gtggatcga 249 342 269 DNA Mycobacterium tuberculosis 342 atgtcgtcac gtcaccacaa tcgcgaggac ccaatcatgc cgcccagggc ggccaaccca 60 atggtggccg cgaagcggca gctcgatcgc agcgcggagg tgccggccgc cagttgattc 120 acgaacaggg tgaggtcata ggcgggcagg atagtgacga acgcaagacc tatatctgcc 180 gtcggagtaa gaatcgagta gccggtcgac caacggaagc gaaagtgtcc gcgatgttga 240 tgagcgtcgc cggttgtggc ggcggtggc 269 343 336 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 343 agcttcacca gcgtgccgat gctgttcgcn acacctccct actatgcgca attcgccgac 60 acgggtggca tcaacacggg cgataaggtg gacatcgctg gggtgaacgt cgggctggtg 120 cgctcgctgg caatccgcgg caaccgcgtg ttgatcggat tctcgttgcc cggcaagaca 180 atcgggatgc aaagccgggc agcaattcgc accgacacca ttcttggccg taagaacctg 240 gaaatcgaac cccgcggttc ggagccgttg aaacccaacg gtttcctgcc gttggcgcag 300 aacactacgc cataccaaat ctatgacgcg ttcgtc 336 344 417 DNA Mycobacterium tuberculosis 344 ctgccgcggt ggcggtcagc gcctggcaag tcaccgcacc gccgtccggt tcatcggcag 60 gctcccccga aaagggccct ggcaacagaa ggtgatcaat gagctcccgc agaccttcgc 120 cgatctggga ccgacatacg tgaagttcgg ccagatcatc gcgtccagcc cgggagcatt 180 cggtgagtcg ctgtcgcggg gaattccgcg gcctgctcga ccgggtgccg cccgcaaaaa 240 ccgacgaggt gcacaagctc ttcgtcgagg aactcggcga cgagccggcc cggctgttcg 300 cctccttcga ggaagaaccg ttcgcgtctg cgtccatcgc ccaagtgcac tacgcgacct 360 gcgcagcggc gaagaagtgt ggtcaagatc cacggccggg catccgccgc cgcgttt 417 345 405 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 345 gatcgtgccg gccccccggc ggcagtagca gatcagctcg tcgaaatcgc ggcaaccagt 60 ccagtcgatt tccatacggg cgccgtcaat caactctgcg aacatcgcga tcggcaccgg 120 aaaccggcga gccgcgtcag ccagcgcaac cagcaccggg atcggatgaa tcatcaatat 180 tatcaagtga tttcctgatg gcatcgagct cggtgatctt ggtctcgggg gccagctcgc 240 cgtcggcgac gtcgtcgatc cggcggccga gcgcatagac cgcaaatagt gccgctcgct 300 tttcgcgcgg caagagtcgg atgccgtaat atangtttct ggcggccgtg cgcgtgatcn 360 actcggtgat tcgatacgcc tgttcatctc ggtcatgccg tcctc 405 346 414 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 346 ggtggcgcaa tgaccgaaac caccccagcc ccgcaaaccc cggcggcccc ggccgggccc 60 gcacaatcgt tcgtgttgga gcggcccatc cagaccgttg ggcgccgtaa ggaggccgtg 120 gtacgagtgc ggctggtgcc cggcaccggc aagttcgacc tcaacggccg cagcttggag 180 gactacttcc caaacaaggt gcaccagcag ttgatcaagg cacccctggt caccgtggat 240 cgggtggaaa gtttcgacat ctttgcccac ctgggcggcg gcggcccgtc gggtcatggc 300 cggcgcgctg cgcctgggta tcgcccgggc attgattctn gtatcgccgg atgaccggcc 360 cgcgctgaat aangccggct tcttgaccgt gatccacgcg ccaccgaacg caaa 414 347 331 DNA Mycobacterium tuberculosis 347 cacaatagat tactcaagct tcgaaccagc ggccttatca cgtatccccg ctgagacctt 60 gacccttagg gccgaagtga cttcgctgct gctatgccga cacccgattt ccagacgctg 120 ctgttacacg acggccgggc cggtggccac catcacgctc aaccgcccgg aacagctcaa 180 caccatcgtc ccgcccatgc ccgacgagat cgaggccgct atcgggttgg ccgagcgcga 240 ccaggacatc aaggtcatcg tgctgcgcgg tgccggccgc gccttctccg gcggttacaa 300 cttcggcggc gggttccaac attgggggca t 331 348 386 DNA Mycobacterium tuberculosis 348 tcaggacgct tatggttggc agatggtcgc cctggcgtcg aatacgcgcg agcgcatgag 60 ctcaccggtt cggaacaacg tatcgaagaa cgtcgcactg ctggcagatg gtatctccga 120 tgtggttgta atttgtatcc caactctaac tgtgctatcg gatcagcgtg aatatcgaga 180 tattgcgaat gcgatgacag gccgccattc ggtttattcg cttacgcttc ccgggttcga 240 ttcgtctgat gcactgccgc aaaacgcgga tatgattgtt gaaaccgtat ctaacgcaat 300 tattgatgtg gtaggcggca gctgccgttt tgtgctgtcg ggctattcat cgggtggggg 360 tgtttggcta tgccctctgc tcccat 386 349 187 DNA Mycobacterium tuberculosis 349 cgcagctgtc gccgatctgg tccggaatac ctagctccag gttctgagtg gagatgagtg 60 cggccatcga agtgttgtca atgtactcca ggatgtcagg tgccaggccg ctggcgagga 120 tcttgggcac cgccgccatg acttggtcga agtcggcgaa cggggcgagc acgctggcgt 180 cgtggtc 187 350 241 DNA Mycobacterium tuberculosis 350 gtagttcgtt catccaaaca cagtgcggta ccggctcaag cggatcaccg acttcaccgg 60 gcgcgatccc acccagccac gcgatgccta tgtccttcgg gtggcggcca ccgtgggtca 120 actcaactat ccgacgccgc actgaagcat cgacagcaat gccgtgtcat agattccctc 180 gccggtcaga gggggtccag caggggcccc ggaaaagata ccaggggcgc cgtcggaccg 240 a 241 351 335 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 351 tccgctcgct tctccgagag gttgagtgcc aacgctctgc cgatgcccga agccggcccc 60 ggtgatgacg gcgaccttgc cttcgaatga gctcatttga ctactccccg tggttgtccc 120 tgcgattggt ggaggtggcc gcgcagcctt gccccgaggt cggcgatcgc gtctcgggct 180 tcggggagca gactgacctg cagatggaag tcgtgccaca tgcccgcgaa ccggcgatgc 240 tcgatgcttg ttttcgaagc ggcgcaggcg gtttcgatct tgtccgcgtc aacacngatc 300 ggatcgtcgc ccgcggtctg catgacgaat gggcg 335 352 441 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 352 atgggaggcc accgattacc atcttgcaca caccgattcc gggctattga tgtccacgtt 60 cggtccgcga accgcgctgt ggctgctgct ggccaaaggc ggaggcgata ccgaagtcag 120 tgcccaagct tgggttccac gctcgcgcag ccacgccgtc acctttccac gagacctcac 180 ctgccgatcc gaaatggaat cggccgtgac ggaattggcg cagcgaacac tcaacgaggt 240 ggtggcttcg tcgcgaaccg tcacccgagt cgcggtcacc gtgcgcacgg cgacgttcta 300 cacccgcacc aagatccgaa agctgcaagc tcccagcacc gatcccgacg tcatcaccgc 360 tgccgcccgg cacgttcttg aacctattcg agctggaatc ggccgtccgg ttgctgggaa 420 ttgcngttaa gaactgggcc t 441 353 332 DNA Mycobacterium tuberculosis 353 gctttgcgcg cttctccgag aggttggagt gccaacgctc tgccgatgcc cgagccggcc 60 ccggtgatga cggcgacctt gccttcgaat gagctcattt gactactccc cgtggttgtc 120 cctgcgattg gtggaggtgg ccgcgcagcc ttgccccgag gtcggcgatc gcgtcgcggg 180 cttcggggag caaactgacc tgcagatgga agtcgtgcca catgcccgcg aaccggcgat 240 gctcgatgct tgttttcgaa gcggcgcagg cggttcgatc ttgtccgcgt caacgcagat 300 cggatcgtcg cccgcgggtc tgcatgaaga at 332 354 334 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 354 ctcacgcagc cacgccgtca cctttccacg aagacctcac ctgccgatcc gaaatggaat 60 cggccgtgac ggaaattggc gcagcgaaac actcaacgag gtggtggctt cgtcgcgaac 120 cgtcacccga gtcgcggtca ccgtgcgcac ggcgacgttc tacacccgca ccaacatccg 180 aaagctgcaa gctcccagca ccgatcccga cgtcatcacc gctgccgccc ggcacgttct 240 tgacctattc gagctggatc ggcccgtccg gttgctggga gtgcggttag aaactggcct 300 agaaaccggc gggcacaccg cacctgggcg gggn 334 355 341 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 355 tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca 60 gctatgacca tgattacgcc aagctattta ggtgacacta tagaatactc aagcttgatg 120 ccgccgaaac cgagcgtgag cacgccgcca gccaccacnc gcgggtcggg cgccgggccc 180 gggtcgccan gctgctccgc tcggtgatgg cacgccaccg cgacaccacc cggctgcgct 240 acgtcgagcc ataccgggcg gagctacatc ggctcggccg cccagtgttc gggccctctt 300 tcgaagtcga agtcgatacc gattgcgcat ccgcngccgc a 341 356 259 DNA Mycobacterium tuberculosis 356 caggcatgca agcttcacgt ccgtacggct cgggtacgct tcggtcgcag tgtgcgagtg 60 atagatgacg accgggacct cgtctgcatc ttccatagcc cgccacacct tcagttgctc 120 accggaatcc aaccggtaga aggtcggcga gcgctcggca ttggtcatcg ggatatgccg 180 ctcgggacgg tcagaaccct cgggtccggc cagcactccg caggcttcgt cggggtggtc 240 gcgacgcgca tgggccacc 259 357 349 DNA Mycobacterium tuberculosis 357 gcttgtctat cgtcccggcc aggtccggcc agtcaaggtc gaaggccagt ccggtctcct 60 ctccgactac ggccaagaac tgggcgacgg tgtcagtgca gaccagcgga aactggtggc 120 gccctaggcg agcgaccgcc tcacaaacgg cggtgaccgc gttctggtcg tgcaccatcg 180 agccgtgccc agcccggccg cgtgccgtca gccgcatcca ctggatgccc ttctcggcgg 240 tttcaatcag gtacaggcga cgttcgccac catcgtgccg gggcacggtt agcgagaaac 300 cgccgacttc acgattgcct cggtgatgcc gtcgaaacag atcgggcct 349 358 325 DNA Mycobacterium tuberculosis 358 gcgcgccatg ttgaggttgt ccgacggtga cgacggtgaa ccacaactgt ttgacctgtc 60 cgcacacacc gtgtggatcg gcgagcggac ccgacaaatc gatggcgcgc acatcgcgtt 120 tgcccaggtg attgctaatc cggtcggggt caagttgggc cccaacatga ccccggaact 180 ggccgtggag tacgtcgagc ggctcgaccc gcacaataag ccgggccggc tgacttggtg 240 agcaggatgg gcaaccacaa ggtccgcgat ctgttgccac cgatcgtgga gaacgtccat 300 gccaccgggc atcaggtcat ctggc 325 359 191 DNA Mycobacterium tuberculosis 359 ttgccttcca tgccgagcaa ggtcgactca gcgatgacga attgttcttc ttcgcgggtg 60 ttgctgctgg ttgcgggcta tgagagcact gctcatatga ttagcacatt gtttctgacg 120 ctggccgact atccagatca gctgacactc cttgcgcagc aaccagacct gatcccgccg 180 gcgatcgagg a 191 360 74 DNA Mycobacterium tuberculosis 360 cgacgctggg cccaactgcg accaccaggt cctggtatgg caggacatgg ccgggttcag 60 cggcgccaat accg 74 361 312 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 361 taacgactcg ggtccagcga ccgcgccaac acnaacggcc ggacnacgtg ggccagggtc 60 gcggcctccc ctacaaacag gatccgttgc ctgcgaacga caggctccgg tgcggcgttg 120 ggcgccgtgc tcgtcccagc gtccggtccc gggtcgccgg cgacgcttgt ttcctccata 180 ctcgccccct aatctcgagg cagcccgtac ccgcaggcaa cctcccaaaa atgcaatccc 240 ccaaaatgca atgcgtcnag ctatttctca caccgaccgc tagttgcgga tcanaaatcc 300 gttgggcgcg ga 312 362 335 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 362 cntggcggtg ggtgcggtgt cgaacacgac cacacttctt tgcggttcgg tgatctcgac 60 accggccgcg agccgaccac catgcgcgcg tagatcggcg atcagcgcgt cggctatcgc 120 ctgggtgccg cccaccggaa tcggccagcc gaccgaatgg gccagcgttg ccatcatcag 180 tccggcgccg gccgacacca gtgacggcaa cggtgaaatc ncgtgggcgg caacgccggt 240 gaacaacgcg cgggcatcct cgcccgccag cgaccgccag gcaggggtgc cctgggccag 300 catccgcagc ccgagacnca ggaccgancc cagtg 335 363 386 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 363 gcttttcnga tcgcagcgag tcgtacccgc gccggtcacc ttcgtggata tcgccggcct 60 ggtcaagggg gcgtccgagg gagccgggct gggtaacaag ttcctggctc atatccgcga 120 atgcnacgcc atttgtcagg tggtgcgggt gttcgtcaac aacnacttga ctcatgtcac 180 cggacgggtc gatccccant ccgacattga ggtcgtcgan accgagctga tcctggcana 240 tctgcaaacc ctggagcggg ccacgggccg gctggagaag gaancgcgca ccaacaaggc 300 gcgcaagccg gtctacgacg cggcactgcg tgcccagcag gtgctcgacg ccggcaanac 360 gctgttcgcc gcgggggtgg atgccg 386 364 386 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 364 gtcgtacgcc attngtcggt gtgcgcatac cagtacgacg cgccgggcac ctgacgcggc 60 ggccgcgacc agtcggtggc catcgccatc gtctgccacc cggtcaacgg acgcaccttc 120 tcctggccga cgtagtgcgc ccacccgccg ccgttgcgtc ccatcnatcc ggtcaacatg 180 agcagcgcca acaccgagcg gtacatgaca tcgctgtgga accagtgaca gattccgccg 240 cccatgatga tcatcgaccg tcctccggat tcggtcgcgt tgcgggcgaa attccttggc 300 aaaccggatt gcctgcgcgg ccggcacacc ggtgatcgac tcctgccagg ccggggtgtt 360 ctgctgggtt cggtcgtggt accggt 386 365 335 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 365 gcgaggcggt atcgcttccc gtcgtaccgg cgaccgccag ccgagaagct cgttttccca 60 gtgttgctgg ggattctcac gctgctgctg antgcgtgcc anaccgcttc cgcttcgggt 120 tacaacgagc cgcggggcta cgatcgtgcg acgctgaant tggtgttctc catggacttg 180 gggatgtgcc tgaaccggtt cacctacnac tccaagctgg cgccgtctcg tccgcaggtc 240 gttgcttgcg atagccggga ggcccggatc cgcaatgacg gattccatgc caacgctccg 300 agttgcatgc ggatcgaata cnaattgatc accca 335 366 396 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 366 tgggtcttgc cggcgagccc agcgaagtcg ctagcgtggc cgtgtttctt ggcttcggat 60 ctatcctcgt tacatgaccg gcaccgtgtt ggacgtgact ggcggccggt tcatatgaca 120 ccgagatcat tgccacggta cggcaattcg tcaagaagga aatctttccc natgcaccgg 180 ccctcgaacg tggcaacagc tacccgcaag aaatcgtcga tcggctgggt gttattggct 240 tgctcggtcg ccggctgcaa gggtatcgac accaccgagt tcattctcgg gcgtgccggc 300 gcattcgagc tggcggtgcg cgctgcccag caccgtcata agtacttgan gatggtcaaa 360 cgtcggacga accgccacca cgtcgctgcc gaacgg 396 367 262 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 367 tagatgccca agcttgccnt tanagacctc gtcgaccaag cacggacgcg accgtcgaag 60 gtggcgaatc cgggcttggc gtcnacccgc gtaaggcaga ccagatggtt cgcggcacgg 120 tcaacctgcc acacggcact ggtaagactg cccgcgtcgc ggtattcgcg gttggtgaaa 180 aggccgatgc tgccgttgcc gcgggggcgg atgttgtcgg gagtgacgat ctgatcgaga 240 ggattcaggg cggctggctg ga 262 368 303 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 368 tctccacggc gtggatcaag gtaccggccg ggatgttgcg caatggcagg ttgttgcccg 60 gcttgatgtc tgcgttagcg ccggattcca ccacatcccc ttgcgaaaag tccgttgggt 120 gcaatgatgt agcgcttctc cccatcgaga tagtggagca acgcaatccg tgcggtacgg 180 ttcgggtcgt actcgatgtg cgcgaccttg gcgttgacac catctttgtc attgcggcga 240 aagtcgatca tccggtaagc gcgcttatga ccgccgcctt tgtgccgggt nggtaatccg 300 gcc 303 369 367 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 369 gcccggttcg atcgggcatg tccgcagtcg tcgttaccgg aggcggtcgt ggccgcgcta 60 atcggcgtcg gcgccgacaa gatgtgggat atccgcaatc ggggcgtcat ccctgcgggc 120 gcgctccccc gcgtccgagc cttcgtcgac gcaatcgagg caagtcacga cgcggatgag 180 gggcagcagt gaattacagc gaggtcgagc tgttgagtcg cgctcatcaa ctgttcgccg 240 gaaacagtcg gcgaccgggg ttggatgcgg gcaccacacc ctacggggga tctgctgtct 300 cgggctgccg acctgaatgt nggtgcgggc ancgccggta tcnactcccg tggaacacag 360 ccggggc 367 370 366 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 370 ctcggcgtgg atatcggtgt agccggcgcc ggtgaangtc ggctccttac gtccactcga 60 caacagctca tagcgatcca accagtangc aaccgccttc agcagtacaa ccgcgccggc 120 gaacactgcg agttgaacgc gagctgcctg ggtcagcatg cctctgccgg ttgtcagccg 180 aaggccgccg aacaggtaat gcgtcaacag gctcgctaga aacgccagaa ccacggccac 240 gaacagccag ttcagcaccg accggtagaa cggcagatcg aagacgaaaa aacccaatgt 300 catagccgaa ttcggggtcc acgatgccaa aggtgccccc gtgtacaaca actgaacctt 360 caccca 366 371 455 DNA Mycobacterium tuberculosis 371 tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta 60 tgaccatgat tacgccaagc tatttaggtg acactataga atactcaagc ttcacgtccg 120 tacggctcgg gtacgcttcg gtcgcagtgt gcgagtgata gatgacgacc gggacctcgt 180 cggcatcttc catagcccgc cacaccttca gttgctcacc ggaatccaac cggtagaagg 240 tcggcgagcg ctcggcattg gtcatcggga tatgccgctc gggacggtca gagccctcgg 300 gtccggccag cactccgcag gcttcgtcgg ggtggtcgcg acgcgcatgg gccaccatcg 360 cattcaccag gtctgcgcga atcaccagca cgtagacggt tcctttccta agcaacaccg 420 aagtttcagg accgaatgct ccgggaaaca tgtca 455 372 196 DNA Mycobacterium tuberculosis 372 caggcatgca agcttgatgc cgccgaaacc gagcgtgagc acgccgccag ccaccacgcc 60 cgggtcgggc gccgggcccg ggccgccagg ctgctccgct cggtgatggc acgccaccgc 120 gacaccaccc ggctgcgcta cgtcgagcca taccgggcgg agctccatcc gctcggccgc 180 cagtgtccgg gccctc 196 373 443 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 373 cctgcatccg gctcgtatgt tgtgtggaat tgtgancgga taacaatttc acacaggaaa 60 cagctatgac catgattacg ccaagctatt taggtgacac tatagaatac tcaagcttcc 120 aatccccctg ccctgatacg cgtcggcaac cgtgaacgcg atctcggcga ccgtcggatc 180 ggtttcatcc cgcacaaaac gcgcgtcggc tacggggtcg cttccgtcgg tcaccaccca 240 gacgaagtgg tcgacgtagt cgacttccga caggtagtgc atcaacgccg gactgggaac 300 acnagccgac atgaaccgtc gatacagcgt ctcnccggag aactggatgt gtccgtgcac 360 ggtccgctcg cggtcaccgg gcagcacggg gcgtaacatc agttgagtcc cgtcggcaag 420 ccgtaccgga atcggggaga cga 443 374 445 DNA Mycobacterium tuberculosis 374 caagatgatc gccggtgcca ccccgatccg tgcctcggtc agcgcgaacg tgctttccgg 60 tccggcgacc accatgtcgc acgcaccgac caggccgaac ccgccggccc gcacatgccc 120 gttgatggcg ccgaccaccg gcagcggcga ctcgacgatg gcgcgcaaca gcgccgtcat 180 ttcccgcgcc cgcgccaccg ccatccggta cggatcacca ccaccaccgc cggcctcgct 240 gaggtccgcg ccggcgcaga acgttccgcc ggtatgcccc agcacgacca gccgcaccgc 300 cggatctgct tcggccgcac tcagcccttg atgtagttgg ctgaccagcg tgctcgacag 360 cgcgttgcgg ttgtgcggag agttcagtgt cagcctggcg aaggggccgc cgcaggcggc 420 cgggccagcg tagtcgacgg ggctg 445 375 308 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 375 ctcaagcttc gatcgacagt actcccgcct tgggtctggt cttcgagctg gtcggtcatg 60 gtcggacctg ctggtagtgg ggatctaacg caacatggtc gggattcatc atggtgtacc 120 cgtgataccc attcgcagct gccggtgaaa ccccgcgatg ccgggatttc cagccgcact 180 aggatgtcta gccggccagc cgctgccgcc ggacttcggg atgttcggta taccaccgat 240 cggcaatctt gcntatccgc cgatgctcga acgctagcca ccccaaacca accactgtga 300 cnacaatc 308 376 239 DNA Mycobacterium tuberculosis 376 tgaatttccc gatcccacaa tctcggttca gatacaggtc gccatacccc ttacttcggc 60 aacgctgggc ggattggccc tgccgctgca gcagaccatc gacgccatcg aattgccggc 120 aatctcgttc agccaatcca tacccatcga cattccgccg atcgacatcc cggcctccac 180 tatcaacgga atttcgatgt cggaggtcgt gccgatcgat gtgtccgtcg acattccgg 239 377 431 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 377 tactcaagct tgaacgctgc gagcgagccc atgtagagcg tttggtacca aaccgatcgg 60 tgggccaact tgccatgggc tcacagcggc tatcgcgagc gtgtagccga tcatcggcca 120 ggcgacggtg gcctgagcgg caggggttgc cttatccatc ctcttgcggc atggttgccg 180 cagggagtgc cggtaagtct ggtcggcaac ctggcccgct gcgggttggg ttcggattcc 240 ctcggctagt aaggtgctcg cctggtgtta caacgaatcg ctagacagct cttatcggga 300 gtggccgtcg cgatcgttgc gctgccgctg gcgatcgcgt tcggcnttac cgccaccgga 360 acgtcccaag gtgcgctcat cgggctctac ggcgccatct tcgccggatt cttcccngcc 420 gtgttcggtg g 431 378 334 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 378 gcggtgtctg aacttcgccc gttccctcca gcgcattgag cttcagcccg accggcaggt 60 agggagtcgg catgcggtcc ttcgccccga ccccgctggc taaatagcca cccccgagcg 120 cggtcacggt ctttgcaccg ggacgacggc ataccggcag cgcgaacatc gccgcgggct 180 gcagcgtgaa cgtcgaatac gagtcgaaca gtgtcggcgc gtaaaaaccc gagccggcgg 240 tcgcttcggt aatcaacggc tcctgcgcaa ccagctgcaa ntcnccggtg ccaccggcgt 300 tgacaatctt gatntcggcg acctcgcgca ccan 334 379 302 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 379 tactcagctt cggctcaggt ggtgctgctg gtaaagttcn ctgaacggtg caggtttcga 60 caatgtggtg ccggttcggc gggtactgcc atcgagacac tggcgcaggc tatcgcaccc 120 gttatcggct acaaacaaat cgcggtatgc gttcttgagc atgagtcggc gaccgtcgtc 180 atggtcgaca cccacgacgg aaagacgcag atcgccgtca agcntgtgtg ccgcggatta 240 tcaggactga cctcctggct gaccggcntg tttggtcncg atgcctggcg cccggccggc 300 gt 302 380 240 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 380 catcacctgg ttcatgaaac tggaagcagc gcagcgcttc cttttcggcc gcaacatgag 60 ccagcctctc gtcggcggtc gggtgcaggt gctcgggcag ctcggccgcg acagccgcct 120 gaccctgaaa ccagcttcca tatcccgcga cgaacgacgc cagtccgcta cgtaacccct 180 ccgcgactgt ccatggacaa cancgcgttc tccaccgacc gggcccgggt gtggggtgtt 240 381 362 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 381 ctcaagcttc ccggcggcca gtaccgaaag cgcgaacagc tcgcggcagc ccacaacntg 60 ctgcgtcgga ttgccggcgg cganatcaat tccaggcagc tcccggacaa tgcggctctg 120 ctggcccgca acgaaggact cgaggtcacc ccggtgcccg gggtcgtggt gcacctgccg 180 atcgcacagg ttggcccaca accggccgct tgatgcccgg tcggcaagcc cggcagttgc 240 caaacccagc gtgatcaggc tcggctcgcg agttcggcga agaagtggct cgcctgatca 300 cctaccatcg gccaggatct gcgtgtcatc acnacgctcg ccaaggaggt tgttgtggtg 360 ct 362 382 411 DNA Mycobacterium tuberculosis 382 gccacgtttc gcgccgcccg gcatacggcg gcgtaccgat ctccgcgtca tacacccgcg 60 ggtaatcgcc gacggtgccg gttcgcgagc cgaaggtgac gacgctgatt gaatcgagtt 120 ccaggtccag cgggtggcgc agcaacggcg cgagctcaac gacgtcaatc acgttgtcgc 180 tttctacggt caccgacccg gtgaccgtag tcgcccggtg cgctcggccg agaagttgca 240 ccgccaccac cgcgacaccg tcttgcacgc ggacgccacc cccggatcgg ttgttggcca 300 aggtaattgg gtcattccat ttgacgggac gccgaccccg cagccccagt accgcccacg 360 accacgccgg ctgaccccac cactgtacga acaccaaggc gacgccgacc a 411 383 331 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 383 ctcaagcttg atgccgccta aaccgaagcg tgagcacgcc gccacccacc acgcgcgggt 60 cgggcgccgg gcccgggccg ccaggctgct ccgctcggtg atggcacgcc accgcgacac 120 cacccggctg cgctacgtca agccataccg ggcggagcta catcggctcg gccgcccagt 180 gttcgggccc tctttcgagg tcnaggtcna taccgatttg cgcatccgca gccgcaccct 240 ggacgacaga accgtgccct acgagtgctt gtcgggcggg gccaaagaac ancttggcat 300 cctggcgcga ttggccggcg cggtcctggt c 331 384 254 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 384 ctcgggtacg cttcggtcgc agtgtgcgag tgatagatga cgaccgggac ctcgtcggca 60 tcttccatag cccgccacac cttcagttgc tcaccggaat ccaaccggta naangtcggc 120 gagcgctcgg cattggtcat cgggatatgc cgctcgggac ggtcagagcc ctcgggtccg 180 gccagcactc cgcaggcttc gtcggggtgg tcgcgacncg catgggccac catcgcattc 240 accaggtctg cgcg 254 385 346 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 385 ctcaagcttc aattcctcca cgacgcgttc ccaaatgaat ttcccgatcc cacaatctcg 60 gttcagatac aggtcgccat accccttact tcggcaacgc tgggcggatt ggccctgccg 120 ctgcagcaaa ccatcgacgc catcgaattg ccggcaatct cgttcagcca atccataccc 180 atcgacattc cgccgatcga catcccggcc tccactatca acggaatttc gatgtcggag 240 gtcgtgccga tcgatntntc cgtcnacatt ccggnggtca ccatcaccgg caccagnatc 300 gacccgattc cgctgaactt cgacgttctc agcagcgccg gaacca 346 386 287 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 386 ttaacccccg tggcctctac gccgcctncg ggtcgaacat gcatcccgag canatgctcg 60 agcgcgcacc ccactcgccg atggccggaa ccggctggtt acccgggtgg cggctgacgt 120 tcggcggcga ggacatcggc tgggaagggg cgcttgccac cgtcgtcgaa gacccagatt 180 cgaaggtgtt cgtcgtgctc tacgacatga ccccggcgga cgagaagaac cttgaccggt 240 gggaaggctc cgagttcggc atccaccana agatccgatg ccgcgtt 287 387 370 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 387 ctcaagcttg attttgatca tcatggatga tcatcacccg aagtgtggta gccgcagtgg 60 ttatcgtggg taccgtcgtg ctttccatgg gcgcctcttt cgggctttcc gtattggtct 120 ggcaggacat tctgggtatc gagttgtact ggatggtgtt ggcgatgtcg gtgatcctgc 180 tcctggcggt gggatccgac tacaatctgc tgctgatttc ccggttgaaa aangaaattg 240 gggccggatt gaacaccgga attatccgtg ccatggctgg taccggggga gtggtgacgg 300 ctgccggcat ggtgttcgcc gttaccatgt cgttgtttgt gttcagcgat ttgcgaatta 360 ttggtcagat 370 388 330 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 388 cgnccaaccc gaattggttt tcggcgccnt cggtgaggac ggcgtgcggg tgctcaacga 60 cgacgtcgtc cgcgggacac acctcgatgc tgccgccatg gacgcggtcg aacgcaagca 120 gctgatcgag ctacaacgcc gcgcggaacg cttccgccnc nggcgttacc gcatcccgtt 180 gaccgggcgg atcgcggtga tcgtcgatga cggcatcgcc accggagcga cggccaaggc 240 ggcgtgccag gtcgcccggg cgcacggtgc ggacaaggtg gtgctggcgg tcccgatcgg 300 cccanacgac atcgtggcga gattcgccgg 330 389 346 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 389 cgtgactgcc accggggcca ctccgcagaa tctgtacccg accaagatct acaccatcga 60 atacgacggc gtcgccgact ttccgcggta cccgctcaac tttgtgtcna ccctcaacgc 120 cattgccggc acctactacg tgcactccaa ctacttcatc ctgacgccgg aacaaattga 180 cncagcggtt ccnctgacca atacggtcgg tcccacgatg acccantact acntcattcg 240 cacgganaac ctgccgctgc tagagccact gcgatcggtg ccgatcgtgg ggaacccact 300 ggcgaacctg gttcaaccaa acttgaaggt gattgttaac ctgggg 346 390 355 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 390 tcgctcaagc gcntgaggcc gaancggctg gttacgactc cctgtttgtg atggaccact 60 tctaccaact gcccatgttg gggacgcccg accagccgat gctggaggcc tacacggccc 120 ttggtgcgct ggccacggcg accgagcggc tgcaactggg cgcgttggtg accggcaata 180 cctaccgcag cccgaccctg ctggcaaaga tcatcaccac gctcgacgtg gttagcgccg 240 gtcgagcgat cctcggcatt ggagccggtt ggtttgagct ggaacaccgc cagctcggct 300 tcgagttcgg cactttcagt gaccggttca accggctcga aaaggcgcta canat 355 391 403 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 391 atactcaagc ttccgctggg gcctgttcaa ccatggcgat cccgttggtc ccggacatcc 60 cgaacgagga caccgcgacc cncttcggtg tgtgatcatt accgttgggc cactgcgtaa 120 ccgcttgcgg cacaaagagc ccggtctcga cgtcggaaag ctcatcgggc acccgattga 180 aatgcagcag cggcggcacc accccgtgcc gcagtgacag aattgccttg atcagcccga 240 cggtccccgc cgatgccgtg ctgtgcccca tgttgctctt ggccgatcca agcgcgcagg 300 gggtgcccgc gccatacacc cgcgccaggc tgcggtactc aatcgggtcg ccgattggcg 360 taccggtgcc gtgcgcctcc accacaccga ccgtttcggg ctg 403 392 440 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 392 caacagcgtt ccagcggcat accaccgcac atgccgtgca cccggcgccg ggcggagtcg 60 ccgcataaca cangtacacc ttgggaatcg gtgtgcgcca gggattcnac cgcggggtgg 120 ggccggcgat cgcgcgccag gtcgagttgg cgccgaccgt gatntcaccg ccgacgtagt 180 tggcgttgtg gtccgccatc cgcgcggcgg gcacggcgcg ggccgccacc acgatgtcac 240 ggaagccggg ggcgaacgct cgacgacctg gttaccgtct cngtcgcntc nancgtggac 300 ccgacngcac gtgggcatat gtccanaacg gacgnggccg gtttcntcga tgcngccggg 360 gtccgcgacn tgcggacncn cngncacacc atccgccagt ccgcgtggcg tcccgccgcg 420 actctgcctc ggccgcgcca 440 393 353 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 393 ctcaagcttt gncgacgatc gggcgatgtc gatganagga aaccccagcg cacaaccgac 60 nattttggcg tagccggcgg acntctgctc gattccgatc acgtcggcgc tcgcatcgag 120 catggcgccg gcgacggcta gcagcgatcc gccgtcgtcg aggaacacga cacgagccgt 180 acgcccggcc gtaagccgcg cccaggattc ggcgaaaaac cgttctacgt ggcgggtgta 240 ctgggtgtcc aatgattcgt ggggtgcgta ggcgtcgctg caatcgtcga cataaatgcc 300 gtcggcccgc atcgcgtcaa caactcccgg gtgagtggaa tancacttgc cga 353 394 340 DNA Mycobacterium tuberculosis 394 tccaacgcgg tgacagattt gtctatcctg gacctgacgg tgaggtcgaa gttttccagg 60 aattcggcaa aatcggtaag agcctgaaga attcggtatc gccggacgaa atctgcgacg 120 catacggggc agatacgctt cgggtttacg agatgtcgat ggggccgctg gaggcttcac 180 gtccatgggc cacaaaggat gttgtcggcg cgtaccgttt tctgcagcgg gtgtggcgct 240 tggtcgtcga cgagcacacc ggcgaaactc gggtggctga cggcgtggaa ctcgacatcg 300 atacgctacg ggcgttgcac cgcaccatcg tcggcgtgtc 340 395 362 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 395 ctcgtccttg actacgccca gtatcgaaan cctcctgtgc cggtncgcta aacacccggc 60 ggacactcan acggtgctgg tggtgcggca tggcaccgcg ggcagcaaag cgcacttctc 120 cggggacgac agcaagcgac cgctagacaa gaggggtcgt gcgcaggcag aagcgttggt 180 accacagctg ctggcgttcg gcgccaccga tgtttatgcc gccgaccggg tgcgctgcca 240 ccanacnatg gagccactcg ccgcggaact gaacgtgacc atacacaacg agcccnccct 300 gaccgaagag tcctacgcca acaaccccaa acgcggccga caccgagtgc tgcagatctt 360 cg 362 396 356 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 396 gtatcgcctc cncctttggc caccagcagc cacagcgcgg ttcgcggacc gaacgtggac 60 atcaatagcc cggaatcggt gtgtgcaagt tggtaaacgg tgttgatccc aagctttgcc 120 agccttttcg tagtcttggg ccccacaccc cacagtgctt cgacggtacg gtcacccatg 180 atggccatcc agttggcatc ggtgagctga tagatgccag ctggtttcgc caacccggta 240 gcgatcttgg cgcgctgctt gttgtcactg atacctatcg agcaagacag cccggtttgc 300 gacaagatga cttttcggat ctcttcngcg aacttccaat gggggtctcc gggant 356 397 350 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 397 ctcaagcttt tggtctagcc ggccgagcac gatacgggtg tccttggcca ccggcggcgg 60 ctgtccggga aatggcgggt ccccggtggt tttgctgang antgctgaac cgtagtcgaa 120 gtgggcggcg tcagactcca cccagccagc aggcagcgcg aagctgaatc ctccaaccgg 180 gttgtcgatc cggacaggtt ggggtgcgtt tggggcaatg acaggtggcg gcggtgcgtt 240 cgggtcggcc ggcggaggtg ctgcgttggg atcncccggc tgggcattcg gcntnttggc 300 ggcggccggt ggtggggggg caacangtgt cccggtgcgg gtggcgctgc 350 398 355 DNA Mycobacterium tuberculosis 398 atctgtaccc gaccaagatc tacaccatcg aatacgacgg cgtcgccgac tttccgcggt 60 acccgctcaa ctttgtgtcg accctcaacg ccattgccgg cacctactac gtgcactcca 120 actacttcat cctgacgccg gaacaaattg acgcagcggt tccgctgacc aatacggtcg 180 gtcccacgat gacccagtac tacatcattc gcacggagaa cctgccgctg ctagagccac 240 tgcgatcggt gccgatcgtg gggaacccac tggcgaacct ggttcaacca aacttgaagg 300 tgattgttaa cctgggctac ggcgacccgg cctatggtta ttcgacctcg ccgcc 355 399 360 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 399 ctcaagcttg caatgcgggt cgggatgccc atggttggaa natggtcgcc ctggcgtcna 60 atacgcgcga gcgcatgagc tcaccggttc ggaacaacgt atcgaaaaac gtcgcactgc 120 tggcagatgg tatctccgat gtggttgtaa tttgtatccc aactctaact gtgctatcgg 180 atcagcgtga atatcganat attgcgaatg cgatgacagg ccgccattcg gtttattcgc 240 ttacgcttcc cgggttcgat tcgtctgatg cactgccgca aaacgcggat atgattgttg 300 aaaccgtatc taacgcaatt attgatgtgg taggcggcag ctgccgtttt gtgctgtcgg 360 400 272 DNA Mycobacterium tuberculosis 400 caaatacacg ccggacgcac aggcggacat cgccatcccg agcacaccca aaacgggata 60 caggatggag gccaacgcca cggccgcgcc caggatcacc aaccacaccg gcttggtcag 120 cttgtcggcg gcggtatagg catcgggccg ctgcaacgca gcatgcacaa acgcgtacac 180 cgctgtcacc aagacggcga ccagcaatac cagcatgacg gtacccacga ggtggctcac 240 gcattcagac tatgcggttt gcatccaaca cg 272 401 306 DNA Mycobacterium tuberculosis 401 ctcgtccttc ggcctcgctg caggagtggg agccgcaggg ctggaaatcc gaaaaacgag 60 ccggtgatcg cactgtcgcc gatcggcgcc gcacctggtt ggtgttacgg atgaatccgc 120 agcgaaatgt ggctgcggtg gcgtgtcgtg actcgttggc gtcgacgctg gtggcagcca 180 ccgagcggtt ggtccaggat ctggatgggc aaagttgtgc ggcccggccg gtgacggccg 240 atgagctgac cgaggtcgac agcgccgtgt tggctgactt ggaaccgaca tggagtcgcc 300 ccggtt 306 402 300 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 402 gtctagnccg ccgaacacga tacgggtgtc attggccacc ggcggcggct gtccgggaaa 60 tggcgggtcc ccggtggttt tgctgaagan tgctgaaccg tagtcgaagt gggcggcgtc 120 agactccacc cagccagcag gcagcgcgaa gctgaatcct ccaaccgggt tgtcgatccg 180 gacaggttgg ggtgcgtttg gggcaatgac aggtggcggc ggtgcgttcg ggtcggccgg 240 cggaagtgct gcgttgggat cgcccggctg ggcattcggc gtgttggcgg cggccggtgg 300 403 396 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 403 actcaagctt gagattggcg tcaacgggtg tcggcaccgg cgtcctgcag ttggtaggcc 60 tgcagtttgt gcatcaggcc gatgccgcgg ccctcgtggc cacgcatgta cancaccacg 120 ccgcgcccct cacgggcgac catcgccagc gcggcgtcca gctgaggccc gcaatcgcag 180 cggcgtgacc caaacacatc gccggtcaag cactccgaat gcacccggac cagcacgtcg 240 tcaccgtcgg cgttgggccc ggcgatctcg ccgcggacca gcgcgacatg ttccacgtcc 300 tcgtaaatgc tggtgtancc gatggcgcga aactccccat gacaantcgg aatcccgcgc 360 ctcggcgacc ccgctcaatg ttgcttctcn tgcttg 396 404 352 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 404 tcgacnagca ttcttgacng ttgttttggc tcggcatggt tagccaaggt tctgcggtcc 60 caccagatca tcttggtccg gtagcgctcg tccgggtatg ctgccgccgg gattctcgct 120 gctattactc cccccgaaga acgccaccgg tccagcgcgt gggccgccgc ggtccccatc 180 acaaactgaa cccccaacag gggacatgct tagcggtagg gcgcgcgcca aggcggcagc 240 aatcgcatca ctgcgctgcg cgtcactatt aacccacccg gacttcactt ccacgacccc 300 gaatggcgcc cggtcattga tcatcttgcg caccgcggat aatccgggat tg 352 405 420 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 405 accggggcca ctccgcacaa tctgtacccg accaanatct acaccatcga atacgacggc 60 gtcgccgact ttccgcggta cccgctcaac tttgtgtcna ccctcaacgc cattgccggc 120 acctactacg tgcactccaa ctacttcatc ctgacgccgg aacaaattga cgcngcggtt 180 ccgctgacca atacggtcgg tcccacnatg acccantact acatcattcg cacgganaac 240 ctgccgctgc taaagccact gcgatcggtg ccgatcgtgg ggaacccact ggcgaacctg 300 gttcaaccaa acttgaaggt nattgttnac ctgggctacg gcganccggc ctntggttat 360 tccacctcnc cgcccaatgt ttgcnactcc cgttcggggt tgttcccnna aggtcaaccc 420 406 328 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 406 cgctcaagcg cntgaggccg aancggctgg ttacgactcc ctgtttgtga tggaccactt 60 ctaccaactg cccatgttgg ggacgcccga ccagccgatg ctggaggcct acacggccct 120 tggtgcgctg gccacggcga ccgagcggct gcaactgggc gcgttggtga ccggcaatac 180 ctaccgcagc ccgaccctgc tggcaaagat catcaccacg ctcgacgtgg ttagcgccgg 240 tcgagcgatc ctcggcattg gagccggttg gtttganctg gaacaccgcc agctcggctt 300 cgagttcggc actttcagtg accggttc 328 407 315 DNA Mycobacterium tuberculosis 407 ctcaagcttg cgttcgatga agtagtcgtc ggtcagcgcc gcctcttcga gctccttggc 60 gatgcccagc aaggagtcat cgccgccgag cttggccagg atcttgtcgg cctgttcctt 120 gacgatgcgg gcccgcggat cgtagttctt gtagacacga tgaccgaaac ccatcaattt 180 gaccccggcc tcgcggttct tgaccttgcg tacaaactcg ctgacgtcgt cgccgctgtc 240 gcgaatgccc tcgagcatct ccaggacagc ctgattggcg ccgccatgaa gcggacccca 300 tagtgcgttg atgcc 315 408 329 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 408 ggtcaggccg agcaggcgcg aggaacgacg aacccaacaa gccatggtgg ttggcgccgt 60 cgagaggtcg gcggtcgcca caacgggaag atcgccttga gcgtcgctcg accgccgcct 120 cgagttgggt cataacgaag tagctgatgc cgatcatgtc gacgtttccg tcgcatcagc 180 gtgcagcggc gacccactcn acgaggtctc ggtgccgccg cggccagggc accagcagtg 240 acgagtccag gcgccgtcgg gccaagcagt cgcggtgcca nccgtggtgg gtcgggcgat 300 ggttgggtgt gctcatttcg ggaacgcca 329 409 294 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 409 ctcgaagctt taacagcatc aaccccgccc cgcaccagca ccgacacnat gtcgatgcca 60 tcgaggtgaa tgtcgaactg gcgcaaacca tcggcgaccg cgaccaccgg caacatgggt 120 accggcgatt tccggtgcca atgccgaccc gacgggccgc tctcaccgca ggtgacctcg 180 atcaccgaga ccanccggcc gttntnntca cgcaccccta ccgtgtcacg cccaaaacgg 240 cgctggtggt cgattgccgg agtgcacccc ncacccagtg tcgtgcccgg atcc 294 410 288 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 410 tgatgccgca cccgatcgac ggtcgttggt cggggttgac tggccgcccg gcgaagcagg 60 gcgtcgaccg cggcccggac gtcggcggcc gtcaccggtc ggccattgcc cgggcgggag 120 tcgtcgagct gaccacggta gacaagtcgg cgctggccgt cgaagacnaa cgtgtcgggt 180 gtgcaggccg cggagaaggc gcgggcgacn tcttgggttt cgtcgtanag atacgggaac 240 gtccagccgt ggcggcgggc ctcggcgacc atctgatcgg gcccgtcc 288 411 420 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 411 tttcgggcga ggcggtatan cttcccntcg taccggcgac cgccagccga naagctcgtt 60 ttcccagtgt tgctggggat tctcacgctg ctgctgantg cgtgccaaac cgcttccgct 120 tcgggttaca acgagccgcg gggctacnat cgtgcgacgc tgaagttggt gttctccatg 180 gacttgggga tgtgcctgaa ccggttcacc tacnactcca agctggcgcc gtctcgtccg 240 caggtcgttg cttgcgatag ccgggaggcc cggatccgca atgacggatt ccntgccanc 300 gctccgagtt gcntgcggat cgactacnaa ttgatcaccc anaaccatcg ggcgtnttac 360 tgcctgaagt acctggtgcg ggtcggatac tgctatccgg cggtgacaac cccggcaagc 420 412 378 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 412 gttttggctc ggcatggtta gccaaggttc tgcggtccca ccagatcatc ttggtccggt 60 agcgctcgtc cgggtatgct gccgccggga ttctcgctgc tattactccc cccgaagaac 120 gccaccggtc cagcgcgtgg gccgccgcgg tccccatcac aaactgaacc cccaacaggg 180 acatgcttag cggtagggcg cgcgccaagg cggcagcaat cgcatcactg cgctgcgcgt 240 cactattaac ccacccggac ttcacttcca cgaccccgaa tggcgcccgg tcattgatca 300 tcttgcgcac cgcggataat ccgggattgc cagcccattc nactaccgca tgcgagtcat 360 cggctgaccg cagcggtc 378 413 347 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 413 tcgcctaggc gggcttcccc ttccgtccga gcngtcagaa gctcctatga caatgcacta 60 cccgagacna tcaacggcct atgcaatacc nagctgatca aacccggcaa gccctggcgg 120 tccatcgagg atgtcgagtt ggccaccgcg cgctgggtcg actggttcaa ccatcgccgc 180 ctctaccggt actgcggcga catcccgccg gtctaactcg acgccgcctc actacgctca 240 acgccagaga ccanccgccg gctgacgtct cagatcagag agtctccgga ctcaccgggg 300 cggttcatcc ccactgtcga tagcgtctgt ggataacttt gtctgca 347 414 165 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 414 gcgcgtngaa ctgataggtg cggcccggct cgagcangcc ggccatttgt tcgatgcggt 60 taccgaagat ctcttcggtg acctgcccgc cgccggccag ctcggcccag tgcccggcgt 120 tggccgccgc ggcgacaatc ttggcgtcca cggtggtctg ggtca 165 415 317 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 415 ctcaagcttc aatacagagt tataaactgt gataatcaac cctcatcaat gatgacnaac 60 taacccccga tatcaggtca catgacgaag ggaaagagaa ggaaatcaac tgtgacaaac 120 tgccctcaaa tttggcttcc ttaaaaatta cagttcaaaa agtatgagaa aatccatgca 180 ggctgaagga aacagcaata actgtgacaa attaccctca gtaggtcaga acaaatgtga 240 cgaaccaccc tcaaatctgt gacagataac cctcagacta tcctgtcgtc atggaagtga 300 tatcgcggaa ggaaaat 317 416 379 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 416 ctcaagcttc gatcgacatt actcccgcct tgggtctggt ctccgagctg gtcggtcatg 60 gtcggacctg ctggtagtgg ggatctaacg caacatggtc gggattcatc atggtgtacc 120 cgtgataccc attcgcagct gccggtgaaa ccccgcgatg ccgggatttc cagccgcact 180 aggatgtcta gccggccagc cgctgccgcc ggacttcggg atgttcggta taccancgat 240 cggcaatctt gcgtatccgc cgatgctcga acgctancca cgccaaacca accactgtga 300 cnacaatcgc caccacacca aaggtcatgc cctcggcgtg atgtccggtg ccgaaagccg 360 caagagctcc gacgccgcc 379 417 420 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 417 cattcccaat tgaatttccc natcccacaa tctcggttca gatacaggtc gccatacccc 60 ttacttcggc aacgctgggc ggattggccc tgccgctgca gcanaccatc gacgccatcg 120 aattgccggc aatctcgttc agccaatcca tacccatcga cattccgccg atcgacatcc 180 cggcctccac tatcaacgga atttcgatgt cggaggtcgt gccgatcgat gtgtccgtcg 240 acattccggc ggtcaccatc accggcacca ggatcgaccc gattccgctg aacttcgacg 300 ttctcagcag cgccggaccc atcaacatct cgatcatcga cattccggcg ctgccgggct 360 ttggcaactc gaccgagctg ccgtcgtcgg gcttcttcaa caccggcggc ggtggcggct 420 418 255 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 418 ctcaagcttt cggcggagac ggacannttg cgaacattga tgacaaaata gaaatcattg 60 atggtttgag tcaccaggcc gatcaagcct tcgccgagcc aaattccaat caagaggccc 120 aagcccgtac caatcagccc ggcaacgagg gattccgtca ttatcagcca aaataactgc 180 tctcgggtta cacccaaaca gcgcaatatg gcgaaaaacg gtcgccgttg cacgacatta 240 aatgtcacgg tattg 255 419 359 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 419 agcttaactg ctccctaata cctggggctg tgcctgcggt gtatgcacgg catacggaca 60 tccntcccct gagacccncg gtctaatcag ccacgtgtcc accatcaggg gtcaaccccg 120 gccaagggcg acggcacccc aagttcgccg accgttaacc tattgctgtg agcttcattt 180 gctgcgagca aaacagttgg tcggccgtta ggaactgaat tgacactcaa ccgatttggt 240 gccnccgtag gtgtcctggc tgcgggtgcg ctggtgttgt ccgcgtgtgg taacgaccac 300 aatgtgaccg ggggaggtgc aaccactggc cacgcgtccg cgaatgtcta ttgcggggg 359 420 314 DNA Mycobacterium tuberculosis 420 ctcaagcttg gggtggcgct gtcggtcggt gtgcttggcg gcgtcggtat caacaccgcc 60 cacgaaatgg ggcacaagaa ggattcgctg gagcggtggc tgtccaaaat caccctcgcc 120 cagacctgct acgggcactt ctacatcgag cacaaccgtg gccatcacgt ccgggtgtcc 180 acaccggagg acccggcgtc ggcgcggttc ggcgaaacgt tgtgggagtt cctgccccgc 240 agtgttatcg gcggcttgcg ctcggccgtt catttggagg cccaacggct gcgtcggctc 300 ggcgtcagcc ccct 314 421 280 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 421 gcaccaaggc cccacacgtc accctgtgac ctcctgcgcc gaccccgccc gaggtcctgg 60 ccgttaccac ctgaacgggc gagccgggag tctggtacgc atcgaacaaa gagcaaggtg 120 catgggcgga gttgttccgc cacttcgtcg atgacggggt cnatccattc gaggtccgtc 180 gccgcgtcgg tcgagtggcg gtcacactcc aggtactcga cctcacagac gagaggactc 240 gatcccatct aggtgtggac gaaacagatc ttctgtccga 280 422 230 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 422 tcgcctccgc atatgggtcg acgccaagcg ggtccggatt tctgggcttc atcgctcgcg 60 ccgtcgcgac aaacagcgcg gtcgaaccga cactcgttgt gatgtcccag ctatcacctt 120 cggtacgcac ccaatcgacc ctacncggct atctcagccg cgatctccag gctccgccga 180 gccaggtgca tcccggtccg gatcccacta acccggcacc attggcgtcn 230 423 272 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 423 gtcctcgagt gccgccgtcg ncacncccag cgcccgcgcg gccacttgga tgcgacccgt 60 ttcaagtccc ttcatcatct gcgaaaagcc ttgacccatg gctccgccca ggatcgccga 120 gaccggcacc cggaggttgt cgaacgacag ctcgcaggat tcgacgccct tgtaacccaa 180 cttcggcaag tcccgcgaca ccgtgagtcc cggcccgggt tcgacgagca cgatcgacat 240 gccttggtgc cgcggtgtgg cgttcgggtc gg 272 424 423 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 424 ggcataccaa tgtggacttc tgctcaccca cgatatccgt ggtctgatcc gctgctgcgg 60 cgggctgcna cctgcntctc ngcggcaccc gtnactacat ggcncgcgcc gcacgcatac 120 gtcgcggcgg gacccactcc nactggtcga cggtgctggc cgcgtgtccg cangtcccna 180 acccggccgc accgacgaaa ccggccgccg tccgttctgg accaacgctc atgtgccgtc 240 ggggtccatg ctcgacgcca tcgagaccgt aaccagcgtc ctcgagcggt tcgcctccgg 300 cttccgtgac atcttcgtgg ctgctcgcgc cgtgccgccg cgcggatggt cgaccacaac 360 gccaaccacc tcggcggtga catcaccgtc cgcgccactc gacctggcgc gcgatcgcgg 420 ccc 423 425 315 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 425 gtgagcagac ctacgccncc tggttgcgcc aactcggtac cgatcatggc gcgcngcctg 60 tcgtcaccga tacccagcga acaagacagc ccggtccgcg acaagatgac tttcccgatc 120 tcttcggcga cttccatggg gtcgtccgga gtcccgggcg ccaccgcgag gtaaccctcg 180 tctcagtccc atacgcgacc gggtatccac gtcgcgcaac aacgccacca cctccccaga 240 cgccncgttg tacgcggctg ggttccacng caataagtgg cctcanggca tcgtccggcg 300 gcggtccnca acgca 315 426 335 DNA Mycobacterium tuberculosis 426 ctcaagcttg aggttaactt tgaacggatc gagctggacg ttcgagacgg tgatcgggcc 60 gaacctgaat tgtccggtaa tgcccaacgc aaaaagcagg gtggtggccg gggcggtgaa 120 accggcgtcg gcggcaccgt cgaaatctat gtggattgcc ggaatgggga tgtccggcac 180 ggcgaaaccg tagttcgctt gtcccgtgag gcccaggtgg atggggggaa agatcctggt 240 gtccgggata ataatggggc cgatgccgcc ggttgaagtc cactggatcg ggaattccgg 300 aatcttgatc cgacgttcag gccgaacagg ccctc 335 427 346 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 427 cggcgacgtc gcgatacgcc gagcagttgg gaatcgctct gcagcaaacc aatattctgc 60 gcgacgttcg agaggacttt ttgaatggac ggatctacct gccgcgcgac gagctggacc 120 gattaggcgt acgcctccgc ctggacgaca ccggggcact cgatgacccc gacggacggc 180 tcgcggcnct gctgcggttc agtgccgacc gcgccgcaga ctggtnttcg ctgggactgc 240 ggctgattcc acacctcgac cgccgcagcg ctgcctgctg tgcggccatg tctggcatct 300 accgccgtca gctcgccttg atcagagcat cgccggcggt cgtcta 346 428 332 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 428 ctataaaata ctcaagcttg atgccgccga aaccgagcgt gagcacgccg ccagccacca 60 cgcgcgggtc gggcgccggg cccgggccgc caggctgctc cgctcggtga tggcacgcca 120 ccgcgacacc acccggntgc gctacgtcna gccataccgg gcggagctac atcggctcgg 180 ccgcccagtg ttcgggccct ctttcgaggt cnaggtcnat accgatttgc gcatccgcag 240 ccgcaccctg aacnacanaa ccgtgcccta ctattgcttg tcnggcgggg ccaaaaaaca 300 gcttggcatc ctggcccnat tggccggcgc gg 332 429 276 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 429 cttcggtcgc agtgtgcgag tgatagatga cgaccgggac ctcgtcggca tcttccatag 60 cccgccacac cttcagttgc tcaccggaat ccaaccggta gaaggtcggc gagcgctcgg 120 cattggtcat cgggatatgc cgctcgggac ggtcagagcc ctcgggtccg gccagcactc 180 cgcaggcttc gtcggggtgg tcgcgacgcg catgggccac catcgcattc accaggtctg 240 cgcgaatcnc cancacgtan acngttcctt tcctaa 276 430 420 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 430 ctggcaccaa ggccccacac gtcaccctgt gacctcctgc gccgaccccg cccgaggtcc 60 tggccgttac caccgaacgg gcgagccggg agtctggtnc gcatcgaaca aanagcaagg 120 tgcatgggcg gagttgttcc gccacttcgt cgatgacggg gtcnatccat tcgaggtccg 180 tcgccgcgtc ggtcnagtgg cggtcacact ccaggtactc gacctcacag acnaaaggac 240 tcnatcccat ctaggtgtgg acnaaacaga tcttctgtcc gacnactaca ccaccaccca 300 ggccatcgcc gccgcccgcg atgccaactt cgacgccgta ctggccccgg cggggggcgc 360 tccccggttg tcaacacttg ccgtgttcnt tcacgcnctg ccccacatcc aaccccaacg 420 431 130 DNA Mycobacterium tuberculosis 431 gttcttgggc ccatgcggag gtatcgccgt ttccaccacg cggtcggggt ggcgttgcat 60 tagctcaccg atggtgcgct tgtgcaggcc gccgggatac cccgagtgcc ggtaaaccat 120 cttgtgctgc 130 432 215 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 432 caatactcaa gcttggcgtg ccgttccaac ccgaattggc tttcggcgcc atcggtgagg 60 acggcgtgcg ggtgctcaac nacnacgtcg tccgcgggac acacctcgat gctgccgcca 120 tggacgcggt cgaacgcaag cagctgatcg agctacaacg ccgcgcggaa cgcttccgcc 180 gcgggcgtga ccgcatcccg ttgaccgggc ggatc 215 433 360 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 433 cntcatgatg atcatcaccc gaagtgtggt agccgcagtg gttatcgtgg gtaccgtcgt 60 gctttccatg ggcgcctctt tcgggctttc cgtattggtc tggcaggaca ttctgggtat 120 cgagttgtac tggatggtgt tggcgatgtc ggtgatcctg ctcctggcgg tgggatccga 180 ctacaatctg ctgctgattt cccggttgaa agaggaaatt ggggccggat tgaacaccgg 240 aattatccgt gccatggctg gtaccggggg agtggtgacg gctgccggca tggtgttcgc 300 cgttaccatg tcgttgtttg tgttcagcga tttgcgaatt attggtcaga tcggtaccac 360 434 265 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 434 atactcaagc ttttacggtg atcgcncatc acctggttca tgaactggaa gcagcgcagc 60 gcttcctttt cggccgcaac atgagccagc ctctcgtcgg cggtcgggtg caggtgctcg 120 ggcagctcgg ccgcnacagc cgcctgaccc tgaaaccagc ttccatatcc cgcgannaac 180 gacgccagtc cgctacgtna cccctccgcg actgtccatg gacaacagcg cgttctccac 240 cgaccgggcc cgggtgtggg gtntt 265 435 264 DNA Mycobacterium tuberculosis 435 gctggtagag tcgctgaccg gtgcaggttt cgacaatgtg gtgccggttc ggcggctacg 60 tgccatcgag acactggcgc aggctatcgc acccgttatc ggctacgagc aaatcgcggt 120 atgcgttctt gagcatgagt cggcgaccgt cgtcatggtc gacacccacg acggaaagac 180 gcagatcgcc gtcaagcatg tgtgccgcgg attatcagga ctgacctcct ggctgaccgg 240 catgtttggt cgcgatgcct ggcg 264 436 335 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 436 gctttccgcc gatacccgcc atgtcncgca catccaggac ttctgggggg atccgctgac 60 agcggcggga tcccaaagtg cggatgatcg ggccgcctac gtcgtggtgt acctcgtcgg 120 taacaacgaa accgaagcgt atgactcggt ccacgcggtg cggcacatgg tggacaccac 180 accgccaccg cacggggtga aggcctatgt caccggtccg gcancactca atgccgacca 240 ggccgaggcc gganacaaaa ntatcgctaa ggtcaccgcg atcacnagca tggtgatcgc 300 agcaatgttg ctagtgatct atcgctccgt aatta 335 437 304 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 437 cttccaaccc gaattggctt tcggcgccat cggtgaggac ggcgtgcggg tgctcaacga 60 cgacgtcgtc cgcgggacac acctcgatgc tgccgccatg gacgcggtcg aacgcaagca 120 gctgatcgag ctacaacgcc gcgcggaacg cttccgccgc gggcgtgacc gcatcccgtt 180 gaccgggcgg atcgcggtga tcgtcgatga cggcatcgcc accggagcga cggccaaggc 240 ggcgtgccan gtcgcccggg cgcacggtgc ggacaaggtg gtgctggcgg tcccgatcgg 300 ccca 304 438 223 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 438 tactcaagct tcgcgagatc cggatggcac tcacgctgga caagaccttc acaaaatctg 60 aaatcctgac ccgatacttg aacctggtct cgttcggcaa taactcgttc ggcgtgcagg 120 acgcggcgca aacgtncttc ggcatcaacg cgtccganct gaattggcag caagcggcgc 180 tgctggccgg catggtgcaa tcnaccagca cgctcaaccc gta 223 439 263 DNA Mycobacterium tuberculosis 439 cccacgactt tctcctcgat cagttggatt tgtacgaaga ggcaacgaaa gcagtgatcc 60 tcgggatggt cgacgcctac atcgacccgc cgttcacgcc gcacagcctg ctagatgcgc 120 tgggcgagca ggtcccacag ttcgccgcta aggcacggcg tctgttcccg tccggatcgc 180 cattcggcct cggcgtcctg ctcccattcg atcaataggg ctggcagctc cgtcggcagg 240 ggcctacgcc tcaccccgtc acg 263 440 301 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 440 ctcaagctta tgcgcgccgg ccgaggtctg ctcacggcaa cccctgaagt ttaggggacn 60 acctactcag cgcaaaattt cgctaatgtg agtccgcccc accaggggna natcaaccca 120 tgtcgatcat gatctacccg gataccggat tggcggtagc gcccacgatc gtcnaaatnt 180 ccgcctgaat catcggatag ctgatccggc gtcaacgcgt tttganttca ccgcgcaaca 240 gccgccaggc cggcccgcan cganccgatc tcntcgggcc gcatgggccc caatcttntc 300 g 301 441 90 DNA Mycobacterium tuberculosis 441 gtgtgtggtg gaacccatct gagcagtgtg ccaaaccggg gcagacagct cccaattgac 60 gtgagcccgc tcacttgctg ggtaagcgtc 90 442 183 DNA Mycobacterium tuberculosis 442 ctttacactt cctgcatccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc 60 acacaggaaa cagctatgac catgattacg ccaagctatt taggtgacac tatagaatac 120 tcaagcttgg gcgtgacggc caccggggcc actccgcacc atctgtaccc gaccaagatc 180 tac 183 443 348 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 443 caggcatgca agctttagct gcccgaatgc gtcaccccga tgcgcccaga tcggggcttc 60 gcagataaag cacgaacagg cgggcaaaac gtcnatctcg gagccggaag ggcaatcagc 120 cgaccgtcga cgaacgacac cggcgagacc acttaggcag tgacggccgg cccgaacatt 180 acgcgctcgt tgattaggcg ttcggtctcg tccgcggtca tgccgagcag cttgcggcag 240 atctgaacgc tgtcctgtcc gggcagcggc gccgggcgtt ggggtgcctg cccgaatgtg 300 acgaaacgga gccggacccg tctcggcggg ccgcggacgg cgatccgc 348 444 335 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 444 cncaagcttg cggatgttac ccctgacagc ctgaactatg tcnaaacaca cggcaccgga 60 acggtgttgg gggaccccat cganttcgag tcgctggcgg ccacttatgg cctgggtaaa 120 ggccagggcn anagcccgtg cgcattgggg tcggtcaaaa ccaacatcgg ccacctggag 180 gcggccgccg gtgtggctgg atncatcaag gcggtgctgg cggtgcaacg tgggcacatt 240 ccccgcaact tgcacttcac ccggtggaac ccggccatcn acgcgtcggc nacgcggctg 300 ttcgtgccna ccnaaaaccc cccgtggccg gcggc 335 445 289 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 445 ggaaccggta accagatcag ctcgtcgacc tcactgccgg gggtgaattc cccaccggtg 60 ctgcgcgctg cccagtagtg caccttcttg acgcctcgaa aaggggagtc ggtcgggtag 120 gtcaccgtca ggagccgcct acccaggttg gcgcnatagc cggtctcctc gagtatctcc 180 cgcaccgccc ccaccggtgc ggtctcaccc anatccactt tgcccttggg cagcgaccag 240 tcgtcgtanc nggggcggtg aatgacaacg atctcgaccg gcccttccn 289 446 263 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 446 tactcaagct tcagaacagg cctgttgtgg gcncacccgg ctcgccgagt tctgcacgca 60 ccgcctcaag tgcggcccgc accgccggca tctcccggtc acgcagggcc gcggcccgcg 120 ccgcagcgac ggcgtgttcg cgcagttcgc cgtcaatgat gctgacctga tcggccaccc 180 gggcgttctc ggcgtcgtcg cgttcactaa tcgcggtgct cagcagcgtc tcgacagcca 240 ccacccgagt ggcgaccagc tgc 263 447 279 DNA Mycobacterium tuberculosis 447 taatgtcttg ccaacgtcac cacaatcgcg atgaattcaa tcatgccgcc cagggcggcc 60 aacccaatgg tggccgcgag cggcagctcg atcgcagcgc ggaggttgcc ggccgccagt 120 tgattcacga acagggtgag gtcataggcg ggcaggatag tgacgaaggc aagacctata 180 tctgccgtcg gaagaagaat cgagtagccg gtcgacacaa cggaagcgaa agtgtccgcg 240 atgttgatga gcgtcgccgg ttgtggcggc ggtggcggc 279 448 295 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 448 tactcaagct ttcgtcagtt catcgcgcca gcagaccaac aagagcatcg ggacatacgg 60 agtcaactac ccggccaacg gtgatttctt ggccgccgct gacggcgcga acgacgccag 120 cgaccacatt cagcanatgg ccagcgcgtg ccgggccacg aggttggtgc tcggcggcta 180 ctcccagggt gcggccgtga tcgacatcgt caccgccgca ccactgcccg gcctcgggtt 240 cacgcagccg ttgccgcccg cagcgganna tcacatcgcc gcgatcgccc tgttc 295 449 280 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 449 ccacccgtgt aatttgggat gggcnaaaag gcnaagcacc gcgtggccac gaacgccggg 60 agggacaatc tcgggcggct agggcttctc gcgggaaggc ccgaacgtac ggcgtttcaa 120 cacgtcgcgt cgccctccga ccgcgaacat tcggggatgg cagcaacctg gtagcaccct 180 ggccgggcga tgatctgcag cgtcgccgcg ggtagtcgcc gcccgggcgg ctacagtctg 240 aaacgcgatg accatcgatg tgtggatgca gcatccgacg 280 450 320 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 450 tcaagcttta gctgcccgaa tccgtcancc cgatgcnccc agatcggggc ttcgcanata 60 aagcacnaac aggcgggcaa aacgtcnatc tcggagccgg aagggcaatc anccgaccgt 120 cnacaaacga caccggcgan accacttagg cagtgacggc cggcccgaac attacncgct 180 cgttgattag gcgttcggtc tcgtccgcgg tcatgccgag cagcttgcgg canatctgaa 240 cgctgtcctg tccgggcagc ggcgccgggc gttggggtgc ctgcggaatg tgacnaaacg 300 gagccggacc cntctcggcg 320 451 203 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 451 ccggggccac tccgcacaat cngtaccnna ccaanatcta caccatcgaa tacgacggcg 60 tcgccgantt tccgcggtac ccgctcaact ttgtgtcgac cctcaacgcc attgccggca 120 cctactacgt gcactccaac tacttcatcc tgacgccgga acaaatngac gcntcggttc 180 cgctgaccaa tacggtcggt ccc 203 452 287 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 452 nctggccttt ggtccacact aanacaatac tcaagcttcc ggccgcagag ccgccaactc 60 acgatatcgt taaccgatat cccgagccga tagctggcgg gctcgggtgg tggccagcgg 120 cgctgcgacn aaaggtgtga ccgtcatgaa acagacacca ccggcggccg tcggccgtcg 180 tcacctgctc ganatctcag catccgcagc cggtgtgatc gcgctttcgg cgtgtngtgg 240 gtcnccgccc gagcccggca aaggccggcc cgacacaacc ccggaac 287 453 272 DNA Mycobacterium tuberculosis 453 catctgccca ccacacggac cgcggtgcgg acgcggctga cgcgcctggt ggtcagcatc 60 gtggccggtc tgctgttgta tgccagcttc ccgccgcgca actgctggtg ggcggcggtg 120 gttgcgctcg cattgctggc ctgggtgctg acccaccgcg cgacgacacc ggtgggtggg 180 ctgggctacg gcctgctatt cggcctggtg ttctacgtct cgttgttgcc gtggatcggc 240 gagctggtgg gccccgggcc ctggttggca ct 272 454 364 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 454 gacaatactc aagcttgact ggccacccac cggcatgacc accgacaggc ccgactggtc 60 gtaccactcg aacgccgggg tgttgatgtc ccagccgctg aantcgtcct gcgcgcgcag 120 gccgtcnaac aggtacaggg cgggcgaatt ggcaccacca ctttggaatt ggaccttgat 180 gtcacggccc atcgacggcg acggcacctg caggtactcc accggcaagc ccggccggga 240 aaatgccccc gcggtcnccg tgccaccgac ggcgccganc aaacccgaca ctagggccgc 300 gccnacggcc ccgaccacna ntcnacgcga catacccgtg acggcgccac naaccctgtc 360 aaca 364 455 360 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 455 cctccaactc ggcggggaag cgacnccagc ctaccgagct tggagtccan gacgccagcg 60 gcggcgtcgg tctgcgtcgt ggtgccgccg gggtggcgtt ggctggcaac gatctccacc 120 cagccggtcg ggttacccac gatctcggca tanacgcggg ccgaggccgg tgcgataccg 180 tattgcgtca attgggacgc ggttgtgcat tcggctagct cggttgccac acccgtcagg 240 ggttcgacgt tggcgggttc ggcgggcccc ancaccgctg tcaccatgcc cgccaagccg 300 acctgcggcg ccaccaactg cagcaccanc atgtcgccgt cgcgcgccgc gatcacatgg 360 456 311 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 456 ctcaagcttt ttgagcgtcg cgcggggcan cttcgccggc aattctacta ncgagaantc 60 tggcccgata cggatctgac cgaantcgct gcggtgcanc ccaccctcat tggcgatggc 120 gccgacnatg gcgcctggac cgatcttgtg ccgcttgccg acggcgacgc ggtaggtggt 180 caagtccggt ctacgcttgg gcctttgcgg acggtcccga cgctggtcgc ggttgcgccg 240 cnaaagcggc gggtcgggtg ccatcaggaa tgcctcnccg ccgcggcact gcacggccag 300 tgccgcggcg a 311 457 288 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 457 cnccagcttg attggtctgg ttgcattggc cagctgcgcg agcctggctc acttcaacta 60 cgacgaccgc aaacaattgc cgccttcgga tccgagttcg gttgggtacg cggcaatgga 120 gcaccatttc tcggtgaatc agactattcc tgagtacttg atcatccact ctgcacacga 180 cctgcgaacc ccgcgcggcc ttgccgacct ggagcagctg gcgcaacgtg tgagccagat 240 cccaggcgtt gccatggttc gcggtgtgac ccggccaaac ggggaaac 288 458 256 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 458 caatactcaa gcttgactgg gcccgcacct tcggcgccac ccacaccgtc aacgcccgcg 60 aagtcnacgt cgtccaggcc atcggcggcc tcacggatgg attcggcgcg gacgtggtga 120 tcgacgccgt cggccgaccg gaaacctacc agcaggcctt ctacgcccgc gatctcgccg 180 gaaccgttgt gctggtgggt gttccnacgc ccgacatgcg cctggacatg ccgctggtcn 240 acttcttctc tcacgg 256 459 327 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 459 tcgacggttt ggcggcctta aatgcactga ggtcgtcaat tgaccccaca gcggaaatgc 60 cgactattcg caggcctcct tcgccttggc tgccggagag gggctccgcg ggaaccgcat 120 gcaggtatat gacctcggtt tctcgggtgc taccgcgtgc cttgtntang atnanctcgg 180 cgttggaatt gtccagccgg cccaattcat cgagcgcana ttcgtacacn tggccggcgg 240 cgacatacgc ttcaccgtgg atctgctcca cacggaccgc cctgtcggga tcctgctcac 300 gggtaangga acttacgtgg cactcgg 327 460 100 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 460 gaccacgcca ggctaatcac gtgacgctac cgaataccct ncctagtggt gcaggctccc 60 gctggaaatg gccctgtacc aactcgcgca ccggtgccag 100 461 114 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 461 cggcacccga cccctttgag ccgtccgccg tggccgcggt ggaactggcc gacgagggac 60 tgatcgtgct gggcaaattg gtcgatggca cgctggccgc cgatctgaag gtcn 114 462 287 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 462 ctcaagcttg ccgttacccc gacttccgga gggacaccat gagcaccgcc agccgagcac 60 gaggccaaac tccgccgacg caggccggtt ggacttgtcg tgctggacaa ggggtttagc 120 cgccgaagca gtgacgtaca tcggcgaaaa gcagttcgcc tgtcgaccga cggngcnnac 180 cgtgaggcta gggaagcgag gagcacatgg ccgccgaccc gcaatgtaca cgctgcaagc 240 aaaccatcga acccggatgg ctatncntca ccgcccatcg ccgcggt 287 463 288 DNA Mycobacterium tuberculosis 463 catgtcgcgc acatccagga cttctggggg gatccgctga cagcggcggg atcccaaagt 60 gcggatgatc gggccgccta cgtcgtggtg tacctcgtcg gtaacaacga aaccgaagcg 120 tatgactcgg tccacgcggt gcggcacatg gtggacacca caccgccacc gcacggggtg 180 aaggcctatg tcaccggtcc ggcagcactc aatgccgacc aggccgaggc cggagacaaa 240 agtatcgcta aggtcaccgc gatcacgagc atggtgatcg cagcaatg 288 464 255 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 464 atactcaagc ttcggtacgg tggcgggccg tgctgctggc cgcggtcgcg gcgtgcgcgg 60 cctgcggtct cgtttacnag ctcgcgctgc tgacactggc ggcnagcctg aacggcggcg 120 ggatcgtggc cacctccctg atcgtcgcgg gctacatagc cgcgctggga gcaggcgcct 180 tgctgatcaa gccgctactt gcacacgcgg ccatcgcgtt catcgccgtg gaggcggtgc 240 tgggcatcat cggcg 255 465 288 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 465 tgtcaagtcc tttcagatct cntttttatg acatgactgg agatctgtct agattgcagc 60 tcctgtgagc gtgggtaccg gattcaagcc ggtcggtcac gccgcggtgg taccggcttt 120 gcggcagtgc tcggcctcga gttcggcgat cgcgcgcgaa gtgcgttcgc gcagcaagat 180 cgcggccgta atgccggcga tgaccgcgat gaccagcgcg atccaggaga accgttccaa 240 ccagtgctgg gcggccatcc cggcgaagta gaccagtgca gtggtgcc 288 466 224 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 466 caatactcaa gcttcaaaac aggcctgttg tgggcgcacc cggctcgccg agttctgcac 60 gcaccgcctc aantgcggcc cgcaccgccg gcatctcccg gtcacgcagg gccgcggccc 120 gcgccgcanc gacggngtgt tcgcgcagtt cgccgtcaat gatgctgacc tgatcggcca 180 cccgggcgtt ctcggcgtcg tcncgttcac taatcgcggt gctc 224 467 320 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 467 tacgctggcg ctggagggag ccanntacaa catccacgcc aatgctcttg ccccgatcgc 60 ggcgaccagg atgacccagg acatcctgcc gcccgaagta ctggaaaagc tcacacccga 120 gttcgtcgca ccggtggtgg cctacctgtg caccgaggag tgtgccgaca acgcatcggt 180 gtacgtcgtc ggtggtggca aggtgcagcg agttgcgctg tttggcaacg acggcgccaa 240 cttcgacaaa ccgccgtcgg tacaagatgt tgcggcgcgg tgggccgaga tcaccgatct 300 gtccggtgcg aaaattgctg 320 468 303 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 468 gcttttcccg tccgtcnncg ctcaaccgcg tgaggccgaa gcggntggtt acgactccct 60 gtttgtgatg gaccacttct accaactgcc catgttgggg acncccgacc agccgatgct 120 ggaggcctac acggcccttg gtgcgctggc cacggcgacc gancggctgc nnntgggcgc 180 gttggtgacc ggcaatacct accgcagccc gaccctgctg gcaaanatca tcaccacgct 240 cgacgtggtt agcgccggtc gagcgatcct cggcattgga gccggttggt ttganctgga 300 aca 303 469 391 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 469 cngcttttta atggccttga cntgggcgng ccggccaccg gggccactcc gcacaatctg 60 tacccgacca agatctacac catcgaatac gacggcgtcg ccgactttcc gcggtacccg 120 ctcaactttg tgtcgaccct caacgccatt gccggcacct actacgtgca ctccaactac 180 ttcatcctga cgccggaaca aattgacgca gcggttccgc tgaccaatac ggtcggtccc 240 acgatgaccc agtactacat cattcgcacg gagaacctgc cgctgctaga gccactgcga 300 tcggtgccga tcgtggggaa cccactggcg aacctggttc aaccaaactt gaaggtgatt 360 gttaacctgg gctacggcga cccggcctat g 391 470 343 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 470 ctcaagcttg ccgggagggt gcatggccga ctcggattta cccaccangg ggcgccaacg 60 cggtgtccgc gccgtcnagc tgaacgttgc tgcccgcctg gagaacctgg cgctgctgcg 120 caccctggtc ggcgccatcg gcaccttcga ggacctggat ttcgacgccg tggccgacct 180 gaggttggcg gtggacgagg tgtgcacccg gttgattcgc tcggccttgc cggatgccac 240 cctgcgcctg gtggtcgatc cgcgaaaana cgaanttgtg gtggaggctt ctgctgcctg 300 cgacacccac nacgtggtgg caccgggcag ctttagctgg cat 343 471 303 DNA Mycobacterium tuberculosis 471 ccgacgccgt cgtggccacc aacaccgcga ccagcaccgt gacccggacc ggggtgccgc 60 gcgaaccggt cttggccaat tgccgcggca ccaagccgtc gcgcgccatg gcgaacagca 120 cgcggcattg cccgagcatc aacaccatca ccaccgtggt aagcccggcc agcgcgccga 180 cggagatgat gccgctggcc cagtacaccc cgttggcctg gaacgcggtg gccagatttg 240 ccggcccgcg gcccggtacg gtccgcagtt gggtgtatgg aaccatgccc gacagcacca 300 ccg 303 472 264 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 472 ttnactggcc tttggtccac actagacaat actcaagctt ccaggacatc gtcatcgcga 60 ccaaaaccgc gagctaggtc ggcatccggg aagcatcgcg acaccgtggc gccgagcgcc 120 gctgccggca ggccgattag gcgggcaaat tagcccgccg cggctcccgg ctccgantac 180 ggcgccccga atggcgtcac cggctggtaa ccacgcttgc gcgcctgggc ggcggcctgc 240 cggatcaggt ggtaaatgcc gaca 264 473 280 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 473 ngacgtcttc catccgcgcg tcgttttggc gggttggcca cagcagcccg ccggtgacgg 60 cgacgatgct gggctggttg cggccctgcg ccaccgcggc ttgcatgctg gttggctgtc 120 ttgggacgat cccgaaatag tccacgcgga tctggtgatt ttgcgggcta cccgcgatta 180 ccccgcgcgg ctcgacgagt ttttggcctg gactacccgc gtggccaatc tgctgaactc 240 gcggccggtg gtggcctgga atgtcgagcg ccgttaccta 280 474 153 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 474 cttcctcctg agtaccnccc gtntactttg ggatgggtaa aaaggcgaat cnccgtttgg 60 tcacgaacgc cgggagggac aatctcgggc ggctggggcc tctcgcggga angcccgaat 120 gtacggtgtc tcgacacttc ccntccccct ccg 153 475 247 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 475 gagcatcggg acntacggag tcaactaccc ggccaacggt gatttcttgg ccgccgctga 60 cggcgcgaac gacgccngcg accacattca gcagatggcc agcgcgtgcc gggccacgag 120 gttggtgctc ggcggctact cccagggtgc ggccntgatc nacatcgtca ccgccgcacc 180 actgcccggc ctcgggttca cgcagccgtt gccgcccnca gcggacgatc acntcgccgc 240 gatcgcc 247 476 264 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 476 tactcatgan catcctttaa tcanngcttt gcgttttttt attaaatctt gcaatttact 60 gcaaagcaac aacaaaatcg caaagtcatc aaaaaaccgc aaagttgttt aaaataagag 120 cancactaca aaaggagata agaagagcac atacctcagt cacttattat cactagcgct 180 cgccgcagcc gtgtaaccga gcatagcgag cgaactggcg aggaagcaaa gaagaactgt 240 tctgtcagat agctcttacg cnca 264 477 264 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 477 ctcaagcttc aggtcaatgt gcnccaagcc ctgacgctgg ccgaccaggc caccgccgcc 60 gganacnctg ccaaggccac cgaatacaac aacgccgccg aggcgttcgc ancccagctg 120 gtgaccgccg agcanancgt caaaaacctc aagacgctgc atgaccaggc gcttancncc 180 gcanctcagg ccaagaaggc cgtcnaacga aatgcgatgg tgctgcacca naagatcgcc 240 gagcgaacca agctgctcag ccng 264 478 352 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 478 catggtggca ctgtagcgac gtgctgcaat caaggtcatg cccgactctg gtcagctcgg 60 anccgctgac accccgctaa ggctgctcag ctcggtgcat tacctcaccg acggcgaact 120 cccccagctt tacgactatc cggatgacgg cacctggttg cgggcgaact tcatcatcag 180 cttggacggc ggcgctaccg tcgatggcac cagcggggcg atggccgggc ccggcgaccg 240 attcgtcttc aacctgttgc gtgaacttgc cgacgtcatc gtggtcggcg tgggcaccgt 300 gcgcattgag ggctactccg gcgtccggat gggtgtcgtc cagcgccagc ac 352 479 207 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 479 tactcaagct tgcgggtgat cgccttggtc aacggcaccg tgatcggatc ggggtcnacc 60 gcacaaatgg actggagctt cggcgaantc atcgcctatg cctcgcgggg ggtgacgctg 120 accccgggtg acntgttcgg ctcgggcacg gtgcccacct gcacgctcgt ctatcacctc 180 nggccaccgg aatcattccc gggctgg 207 480 256 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 480 gttggngcct cgtcggcgaa cagttctcgc acgatttccg gattagcggg actggtcacc 60 agttgggtat gcgggaaggc gctgacgttc gccgcgatta gctgtttgat ggacgcggtg 120 gtgatgttct gatcacggaa ctggctgtaa tagcccaggg tcgccacgct ttcatccggg 180 cccggacccg gcgcaccgag cgtgtcgcgc aggtatgcga cgtgattttc gctgaagtcc 240 ccgtacccgg agaact 256 481 397 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 481 tgcttccggc tcgtatgttg tgtggaattg tgancggata acaatttcac acaggaaaca 60 gctatgacca tgattacgcc aagctattta ggtgacacta tagaatactc aagctccagg 120 tcaatgtgcg ccaagccctg acgctggccg accaggccac cgccgccgga gacgctgcct 180 ttgtcaccga atacaacaac gccgccgagg cgttcgcagc ccagctggtg accgccgagc 240 agagcgtcga agacctcaag acgctgcatg accaggcgct tagcgccgca gctcaggcca 300 agaatgccgt cgaacgaaat gcgatggtgc tgcggcataa gatcgccgag cgaaccaagc 360 tgctcagcca gctcgagcag gcgaagatgc acgagca 397 482 379 DNA Mycobacterium tuberculosis 482 caggcatgca agcttcggag gcagacccgt gcatggtggc actgtagcga cgtgctgcaa 60 tcaaggtcat gcccgactct ggtcagctcg gagccgctga caccccgcta aggctgctca 120 gctcggtgca ttacctcacc gacggcgaac tcccccagct ttacgactat ccggatgacg 180 gcacctggtt gcgggcgaac ttcatcagca gcttggacgg cggcgctacc gtcgatggca 240 ccagcggggc gatggccggg cccggcgacc gattcgtctt caacctgttg cgtgaacttg 300 ccgacgtcat cgtggtcggc gtgggcaccg tgcgcattga aggctactcc ggcgtccgga 360 tgggtgtcgt ccatcgcca 379 483 264 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 483 tactcaagct tggggtggcg ctgtcggtcg gtgtgcttgg cggcgtcggt atcaacaccg 60 cccacgaaat ggggcacaag aaggattcgc tggagcggtg gctgtccaaa atcaccctcg 120 cccanacctg ctacgggcac ttctacatcg agcacaaccg tggccatcac gtccgggtgt 180 ccacaccgga ggacccggcg tcggcgcggt tcggcnaaac gttgtgggan ttcctgcccc 240 gcantgttat cggcggcttg cgct 264 484 351 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 484 ggccatcgcc accgcnccgc ggcgaacgct caaaggcacc tactggcacc aaggccccac 60 acgtcaccct gtgacctcct gcgccgaccc cgcccgaggt cctggccgtt accaccgaac 120 gggcgagccg ggagtctggt acgcatcgaa caaagagcaa ggtgcatggg cggagttgtt 180 ccgccacttc gtcgatgacg gggtcgatcc attcgaggtc cgtcgccgcg tcggtcgagt 240 ggcggtcaca ctccangtac tcgacctcac agacgagagg actcgatccc atctaggtgt 300 ggacgaaaca gatcttctgt ccgacgacta caccaccacc caggccatcg c 351 485 328 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 485 gcttgcgggt gatcgccttg gtcaacggca ccgtgatcgg atcggggtcn accgcncaga 60 tggactggan cttcggcgaa ntcntcgcct atgcctcgcg gggggtgacc ctgaccccgg 120 gtgacntgtt cggctcgggc acggtgccca cctgcacgct cgtcaagcac ctcnggccac 180 cggaatcatt cccgggctgg ctgcacnacg gcgacntggt cnccctccag gtcgaagggc 240 tgggcnaaac aangcagacc gtccggacaa ncggcactcc ttttccgttg gctcttcggc 300 cgaatccgga cgccnaaccc gaccggcg 328 486 344 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 486 gttctcgcac gatttccgga ttagcgggac tggtcaccag ttgggtatgc gggaaggcgc 60 tgacgttcgc cgcgattagc tgtttgatgg acgcggtggt gatgtnctga tcacggaact 120 ggctgtaata ncccagggtc gccncgcttt catccgggcc cggacccggc gcaccgagcg 180 tgtcgcgcag gtatgcgacg tgattttcgc tgaagtcccc gtacccggag aactcgaaca 240 cgctgaggcg ctcgtcaccg tcgtnncggc gaccaagcgc ggcgagcaac tgcgcaaaat 300 cgttaagana ggtcgaatcg ttgaaattcg gcaccacctg cacc 344 487 285 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 487 cacaagacaa tactcaagct tcaggtcaat gtgcnccaag ccctgacgct ggccgaccag 60 gccaccgccg ccgganacgc tgccaaggcc accgaataca acaacgccgc cgaggcgttc 120 gcagcccagc tggtgaccgc cgagcananc gtcnaaaacc tcaagacgct gcatgaccag 180 gcgcttancg ccncagctca ggccaagaag gccgtcgaac gaaatgcgat ggtgctgcag 240 canaanatcg ccgancgaac caagctgctc agccagctcg agcag 285 488 280 DNA Mycobacterium tuberculosis 488 ccacccgtgc atggtggcac tgtagcgacg tgctgcaatc aaggtcatgc ccgactctgg 60 tcagctcgga gccgctgaca ccccgctaag gctgctcagc tcggtgcatt acctcaccga 120 cggcgaactc ccccagcttt acgactatcc ggatgacggc acctggttgc gggcgaactt 180 catcagcagc ttggacggcg gcgctaccgt cgatggcacc agcggggcga tggccgggcc 240 cggcgaccga ttcgtcttca acctgttgcg tgaacttgcc 280 489 160 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 489 gctttccgcc gatacccncc atgtcccgca catccaggac ttctgggggg atccgctgac 60 agcggcggga tcccaaagtg cggatgatcg ggccgcctac gtcgtggtgt acctcgncgg 120 taacaacgaa accgaancgt atgactcngt ccacgcggtg 160 490 176 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 490 caacccgant tggctttcgg cgccntcggt gaggacggcg tgcgggtgct caacgacgac 60 gtcgtccgcg ggacacacct cgatgctgcc gccatggacg cggtcgaacg caagcagctg 120 atcgatctac nacgccgngn ggaacgcttc ngccgcgggc gtgaccgcnt cccgtt 176 491 216 DNA Mycobacterium tuberculosis 491 gggatgggca aaaaggcgaa gcaccgcgtg gccacgaacg ccgggaggga caatctcggg 60 cggctagggc ttctcgcggg aaggcccgaa cgtacggcgt ttcaacacgt cgcgtcgccc 120 tccgaccgcg aacattcggg gatggcagca acctggtagc accctggccg ggcgatgatc 180 tgccagcgtc cccgcgggta gtcgccgccc gggcgg 216 492 163 DNA Mycobacterium tuberculosis 492 cagcagacca acaagagcat cgggacatac ggagtcaact acccggccaa cggtgatttc 60 ttggccgccg ctgacggcgc gaacgacgcc agcgaccaca ttcagcagat ggccagcgcg 120 tgccgggcca cgaggttggt gctcggcggc tactcccacg gtt 163 493 80 DNA Mycobacterium tuberculosis 493 ctcaagcttg actggccacc caccggcatg accaccgaca ggcccgactg gtcgtaccac 60 tcgaacgccg gggtgtttga 80 494 248 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 494 ttggtgcccg gaatggcgag tcccatttan tcgctgattt gtttgaacag cgacgaaacc 60 ggtgttgaaa atgtcgcctg ggtcggggat tccctctcca agcaagagta actggcccca 120 aataaagtta ctcgtcgtct tgcaaagacc gctacccgat gccatttatg tgtttcctta 180 cgctcnnnnt tccggtgcgc catcattatc tgcacctttg cactgcacat tgagcttagc 240 agcgctcg 248 495 341 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 495 gaattngctt tcggcgccat cggcccagga ccgcgtgcgg gtgctcaacg acgacgtcgt 60 ccgcgggaca cacctcgatg ctgccgccat ggacgcggtc gaacgcaagc agctgatcga 120 gctacaacgc cgcgcggaac gcttccgccg cgggcgtgac cgcatcccgt tgaccgggcg 180 gatcgcngtg atcgtcgatg acggcatcgc caccggagcg acggccaagg cggcgtgcca 240 ggtcgcccgg gcgcacggtg cggacaaggt ggtgctggcg gtcccgatcg gcccagacga 300 catcgtggcg agattcgccg ggtacgccga tgaagtggtg t 341 496 420 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 496 taaagctttc gtcagttcat ngngcccccg gaccaacaaa agcatcggga catacggagt 60 caactacccg gccaacggtg atttcttggc cgccgctgac ggcgcnaacg acgccagcga 120 ccacattcag cagatggcca gcgcgtgccg ggccacgagg ttggtgctcg gcggctactc 180 ccagggtgcg gccgtgatcn acatcgtcac cgccgcacca ctgcccggcc tcgggttcac 240 gcagccgttg ccgcccgcag cggacgatca cntcgccgcg atcgccctgt tcgggaatcc 300 ctcgggccgc gctggcgggc tgatgagcgc cctgacccct caattcgggt ccaanaccat 360 cnacctctgc aacaacggcg acccgatttg ttcggacggc aaccggtggc gancgcacct 420 497 135 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 497 ccgggaggga ccatcncggg cggctncggc ttctctccgg aaggttctan ngtnnngcgt 60 ttcnacnctt cccgtcgccc tgcgaccgcc gaacattcgg ggtatggnng cancctgtna 120 gcatccnggc cgggc 135 498 277 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 498 ctcaagcttc cgcatcagat cgctatagaa ccggtgcgcg tccccaccga gtggctggtc 60 gccttccagc acgatcgtta ccgcgttatc ggaatcaaac tcnccgaaca cctgaccaac 120 gcgcttgatc gcctgaatcg atgcggcgtc gctggggctc atcgataccg agtgtgcttt 180 tccgaccact tccagttgcg gtacggcgag attgacaaag gcggtgaagc ccagccagag 240 caggacgatc accnccgcaa accggcggat ttgcccg 277 499 323 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 499 gcttggcagc ctgcggctgg gcgccctnga gctcttcgat ctggatctcc ggactcgaga 60 tgctcacttg cccggccgtg gacgtaccca ttgcggccgg gaccccagcg ccccaggtga 120 ccagcgagtt gggctgcacg ctgaccggcc cgtcggggtc gacgccggta acggtcagca 180 gctccgangt ccnnctgatc ccgaccgcag ctgccaatgc gcggctggca gccgacgtgg 240 atgtgccggg gcctagatcg cggggcagca gcgagaccgc gtcaccgacg gtcatcacct 300 tgccgagttt nggcctgccg can 323 500 148 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 500 gcttccggct cgtatgttgt gtggaattgt gagcggataa caattncaca caggaaacag 60 ctatgaccat gattacgcca agctatctag gtgacactat agaatactca agcttgagcc 120 atcgggctat cagctggttg atgtcccg 148 501 242 DNA Mycobacterium tuberculosis 501 caggcatgca agcttgtcgt ctatcacatc cgaccaccaa ccgcccgacg gctcggcaga 60 acgcctccgc atatgggtcg acgaccagcg ggtcggactt ctgggctgcc agcgctcgcg 120 ccgtcgcgac aaacagcgcg gtcgaaccga cactccttgt gatgtcccac ctatcacctt 180 cggtacgcac ccaatcgacc ctacgcggct agctcagccc cgatcttcca gagctccgcc 240 cg 242 502 230 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 502 gctttttgag cgtcgcgcgg ggcggcttcc ccggcaattc tactagcgag aagtctggcc 60 cgatacggat ctgaccgaag tcgctgcggt gcagcccacc ctcattggcg atggcgccga 120 cnatggcgcc tggaccgatc ttgtgccgct tgccgacggc gacgcggtag gtggtcaatt 180 ccggtctacg cttgggcctt tgcggacggt cccgacgctg gtcgcggttg 230 503 235 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 503 cgancctgtt cgacggctac ctgaatcacc ccgatnccac cgccgcggcg ttcgacgccg 60 acagctggta ccgcaccggc gacgtcgcgg tggtcgacgg cagtgggatg caccgcatcg 120 tgggacgcga gtcggtcgac ttgatcaagt cgggtggata ccgggtcggc gccggtgaaa 180 ttgaaacggt gctgctcggg catccggacg tggcggaggc ggcagtcgtc ggggt 235 504 152 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 504 naagctttgt cacaccaagt gtttcnacca gncgctccat ccggcgaagt ggatactccc 60 agcaggtagc aggtcgccac cacgctggtc agtgcgcgtt cagctcgctt gcggcgctgc 120 agcagccagt ccgggaaata gctgccctgg cg 152 505 192 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 505 cgctggncgc cggcgctggg ctgcggtaac caattaccac aacacttttc ggtagccgaa 60 cagcggcgcg taccagcgaa atggcacagc caccgcagtc gccgacatcc cgcgaagatg 120 tggcagattt tcgtgcggtc gagccggcga aggcctagcg tcattgttgc ctggcaaggt 180 tgctgggccc gg 192 506 312 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 506 ctcaagcttc ttctgcccct tgccgttncg gatnacatcc cgcagcgact cggcttcggc 60 gtcgatgtcg aagttctcga tcagcttctg gatcgactcc gcgcccatgg caccggtgaa 120 gtactcgccg tagcggtcga cnagttcgcg gtagaggttt tcgtcnacna tcagctgctt 180 gggcgccanc ttggtgaaag tgctccaaat gtcctccaac cggtccagct cacgctgcgc 240 gcggtcacgg atctggcgca tctcgcgctc gccgccgtcg cgaacttgcg ccgcgcatcg 300 gccttggggc cc 312 507 296 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 507 gttcacacct acctactatg ccncaattcn ccgacacggg tggcatcaac acgggcgata 60 aggtggaaat cgctggggtg aacgtcgggc tggtgcgctc gctggcaatc cgcggcaacc 120 gcgtgttgat cggattctcg ttgcccggca agacaatcgg gatgcaaagc cgggcagcaa 180 ttcncnccna caccattctt ggccgtaaga acctggagat cgaaccccgc ggttcggagc 240 cgttgaaacc caacggtttc ctgccgttgg cgcanaccac tacgccatac caaatc 296 508 208 DNA Mycobacterium tuberculosis 508 ctcaagcttt acgccgacgc cggcctacac aacaccaagg aaacgattgc ctactgccga 60 atcggggaac ggtcctcgca cacctggttc gtgttgcggg aattactcgg acaccaaaac 120 gtcaagaact acgacggcag ttggacagaa tacggctccc tggtgggcgc cccgatcgag 180 ttgggaagct gatatgtgct ctggaccc 208 509 278 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 509 tcccncatgg gataacgggt ttagatttcn acaacggcac cgtgtttctc aacaagccgg 60 tcatcagctg ggccggcgac aacggtatct acttcacccg ctttcgcccg tacaagaaaa 120 accactaggc caccatcgag tccaagaaca accacctggt ccgcaagtac gcgttctact 180 accgctatga caccgccgag gaacgcgccg tgctcaaccg gatgtggaag ctggtcaacg 240 accgcctcaa ctacctcacc ccgaccatca aaccgatc 278 510 177 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 510 ctcaagcttg ggtgttgccg atcaccggaa gccncatgat cagccacgtt tcgcgccgcc 60 cggcatacgg cggcgtaccg atctccgcgt catacacccg cgggtaatcg ccgacggtgc 120 cggttcgcga gccgaaggtg acaacgctga ttgaatcnag ttccangtcc agcgggt 177 511 296 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 511 tnaacagctc gcggcagccc acgacctgct gcgtcggatt gccggcggcg agatcaattc 60 caggcagctc ccggacaatg cggctctgct ggcccgcaac gaangactcg aggtcacccc 120 ggtgcccggg gtcgtggtgc acctgccgat cgcacaggtt ggcccacaac cggccgcttg 180 atgnnnngtc ggcaagcccg gcagtngcca aacccagcgt gatcangctc ggctcgcgag 240 ttcggcgaan aagtggctcg cctgatcacc taccatcggc cangatctgc gtgtca 296 512 223 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 512 gccanccggc ttggcgtcga ctcccgttcn gcacatcata cggtccccgg tactgtccaa 60 ctgcgccggt gcgctagcca aacgtcacga ctctcagtga tcccagttcg tgatccggcc 120 ggtggcgccg ctgcggcggg ggctnatnta cttcggactn attatctcat ccaaaggaca 180 ccgggccggt ggctggaatc ccatggtgcg atcggccaca can 223 513 147 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 513 ccgacctggt atcttccgat agcgcgcgtt gatatccggt ctgatctcct gcccttaacg 60 ccggatctca gcaggtcccc atgcaaagat ccgaggtgtc ccngatctag gggtcctcgt 120 cctccagatg atggagcaag tcggccc 147 514 149 DNA Mycobacterium tuberculosis 514 ctcaagcttc ggctcaggcg gcgctgccgg taacgtcgct gaccggtgca ggtttcgaca 60 atgtggtgcc ggttcggcgg ctacgtgcca tcaagacact ggcgcaggct atcgcacccg 120 ttatcggcta caaacaaatc gcggtatgc 149 515 238 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 515 catcacctgn ttcatgaact ggaagcaccg cagcgcttcc ttttcggccg caacatgagc 60 cagcctctcg tcggcggtcg ggtgcaggtg ctcgggcagc tcggccgcga cagccgcctg 120 accctgaaac cagcttccat atcccgcgac gaacgacgcc agtccgctac gtaacccctc 180 cgcgactgtc catggacaac agcgcgttct ccaccgaccg ggcccgggtg tggggtgt 238 516 175 DNA Mycobacterium tuberculosis 516 agcttagctt cccgccccgg caatagggct ccagctcatc cggtgtgacc agataggggc 60 ccagggtgat accgctgtct ttgcccttgg cctgtccgat gcgcagctgg ccctccagca 120 tctgcaggtc ccgtgcggac cagtcgttga aaatggtata gccgatgatc gaccg 175 517 144 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 517 ccngaacaga agcggnggtt cctaccgcgg tgtgcggccg gcgcgatatc ggccttttta 60 ctaaccgaac ccgatgtggg ctccgatccg gcgcgcatgg catcgacggc gacgccgatc 120 gatgaccgcc aggcttacca cctt 144 518 174 DNA Mycobacterium tuberculosis 518 ctcaagcttg cgcgactcga caagcattct tgacagttgt tttggctcgg catggttagc 60 caaggttctg cggtcccacc agatcatctt ggtccggtag cgctcgtccg ggtatgctgc 120 cgccgggatt ctcgctgcta ttactccccc cgaagaacgc caccggtcca gcgc 174 519 187 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 519 gcnaggcggt atagcttccc gtcgtaccgg cgaccgccag ccgagaagct cgttttccca 60 gtgttgctgg ggattctcac gctgctgctg agtgcgtgcc agaccgcttc cgcttcgggt 120 tacaacgagc cgcggggcta cgatcgtgcg acgctgaagt tggtgttctc catggacttg 180 gggatgt 187 520 215 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 520 gtgtggaacc gtgagcggat aacaatttca cacaggaaac agctntgacc ttgattacgc 60 caagctattt aggtgaggct atattaatac tcaagattgc ggtcgagcac atcggcccaa 120 gaaccgccga aggcacggcg gaacgcctgc ggcacatggg gcgacgacca gcgggtcgga 180 cttctgggct gtccagccgg atcgcgccgt cgcga 215 521 406 DNA Mycobacterium tuberculosis 521 cactgtcagt acatatgcgc cgctcctcct catcgctgcg ctcggcatcg tcgccggcgg 60 tcatggcgtc accctaccca agccgaacgc gaaacgagaa cgtgttccat tattagggtg 120 tgagcaccaa taccagattg ctcaccagga actcacgcag caccgggacg gatgtcagcc 180 accacgccca tctggggtgg tagcggggaa atacggctaa cgcggctccg gtgccggcag 240 cccagcgcag accctcggcg gcggacacgg caaacaacga cgacccatag ttgttctttg 300 ccggatggcc gtgtttgcgg acatatcggg cggcggcgcg ggcgccgccg aggtagtggc 360 tgaggcccat ctcgtgcccg ccgaatggcc ccagccaaac cgtgta 406 522 180 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 522 ctcaagcttt tacggtgatc gcgcatcacc tggttcatga actggaagca gcgcagcgct 60 tccttttcgg ccgcaacatg agccancctc tcgtcggcgg tcgggtgcag gtgctcgggc 120 agctcggccg cgacagccgc ctgaccctga aaccagcttc catatcccgc gacnaacgac 180 523 69 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 523 ctcagaagcc gctagctggt agagtcgctg accggtgcac gtggcgncaa tgtgcgctgc 60 cggttcgcg 69 524 168 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 524 ctcaagcttg cgctcatcaa gcgcgaacag cagggcggtc ggctggtcgc catgacgggt 60 gacgggacca atgacgcacc cgcgctcgcg caagccgatg tcggggtggc natnaatacc 120 ggcacccagg cggcccggga agccggcaac atggtcnatc tccactcc 168 525 83 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 525 acttctattt cgactggtgt gctgtggcgc gatccgactg ccggcgtggt caaggccggc 60 cagttgtggg atnccacagg cac 83 526 173 DNA Mycobacterium tuberculosis 526 gcttgtcgta ttccgtggca ctgtcagaca tatgcgccgc tcctcctcat cgctgcgctc 60 ggcatcgtcg ccggcggtca tggcgtcacc ctacccaagc cgaacgcgaa acgagaacgt 120 gttccattat tagggtgtga gcaccaatac cagattgctc accaggaact cac 173 527 38 DNA Mycobacterium tuberculosis 527 cgatattcgt cggccgcgtt gtctcgactg ggtcgcgt 38 528 136 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 528 gacctcggcc accaagccgg acgcgaccgt cgaggtggcg atccggcttg gcgtcgaccc 60 gcgtaaggca gaccacatgg tccgcggcac ggccancctg ccacacggca ctggtaagac 120 tgcccgcgtc gcggcn 136 529 114 DNA Mycobacterium tuberculosis 529 ccggaagtct aggggacgac ctactcagcg caaaatgtcg ctaatgtgag tccgccccac 60 cagggcagat caacccatgt cgatgatgac ctacccggat accggattgg cggt 114 530 119 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 530 agcttcagtt cctccacgac gcgttcccaa atgaatttcc cgatcccaca atctcggttc 60 agatacaggt cgccataccc cttacttcgg naacgctggg cggattggcc ctgccgctg 119 531 99 DNA Mycobacterium tuberculosis 531 ccgcctacgg gtcgaacatg catcccgaga ccgatgctcg agcgcgcacc ccactcgccg 60 atggccggaa ccggctggtt acccgggtgg cggctgacc 99 532 308 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 532 gcggctggtt acgactccct gtttgtgatg gaccacttct accaactgcc catgttgggg 60 acgcccgacc agccgatgct ggaggcctac acggcccttg gtgcgctggc cacggcgacc 120 gagcggctgc aactgggcgc nttggtnacc ggcaatacct accgcagccc gaccctgctg 180 gcaaagatca tcaccacgct cgacgtggtt agcgccggtc gagcgatcct cggcattgga 240 gccggttggt ttgagctgga acaccgccag ctcggcttcg agttcggcac tttcagtgac 300 cggttcan 308 533 328 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 533 gcctttccgc acaatctgta ccccaggacc ntctaaaaaa tcgaatacga cggcgtcgcc 60 gactttccgc ggtacccgct caactttgtg tcgaccctca acgccattgc cggcacctac 120 tacgtgcact ccaactactt catcctgacg ccggaacaaa ttgacgcagc ggttccgctg 180 accantnntg tcggtcccac gatgacccag tactacatca ttcgcacgga gaacctgccg 240 ctgctagagc cactgcgatc ggtgccgatc gtggggaacc cactggcgaa cctggttcaa 300 ccaaacttga aggtgattgt taacctgg 328 534 75 DNA Mycobacterium tuberculosis 534 gcagaccaac aagatgcatc gggatcatac gccgtcaact acccggccaa cggtgatttc 60 ttggccgccg cccac 75 535 319 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 535 ctcaagcttg ccaaagagac ctcgtccacc aagcnggacg cgaccgtcna ggtggcgatc 60 cggcttggcg tccacccgcg taaggcanac canatggttc gcggcacggt caacctgcca 120 cacggcactg gtaanactgc ccgcgtcgcg gtattcgcgg ttggtgaaaa ggccgatgct 180 gccgttgccg cgggggcgga tgttgtcggg agtgacaatc tgatcganag gattcagggc 240 ggctggctgg aattcgatgc cgcgatcgcg acaccggatc agatggccaa agtcggtcnc 300 atcgctcggg tgctgggtc 319 536 312 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 536 ccacggcgtg gatcaaggta ccggccggga tgttgcgcaa tggcaggttg ttgcccggct 60 tgatgtcggc gttagcgccg gattccacca catccccttg cgaaagtccg ttgggtgcaa 120 tgatgtagcg cttctcccca tcgagatagt ggagcaacgc aatccgtgcg gtacggttcg 180 ggtcntactc gatgtgcgcg accttggcgt tgacaccatc tttgtcattg cggcgaaagt 240 cgatcatccg gtaagcgcgc ttatgaccgc cgcctttgtg ccgggtggta atccggccat 300 gcgcgttgcg tc 312 537 105 DNA Mycobacterium tuberculosis 537 ggcggctgcg tcggcgagat gatcgcccgg tgccaccccg atccgtgcct cggtcagcgc 60 caacgtgctt tccggtccgg cgaccaccat gtcgcatgcg ccgac 105 538 144 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 538 gcaatcgcct tggcggtcgc cgggttgtca ccggtgatca tcncggngcg gatgctcatn 60 cggcgcattt cgtcnaatcg ttcccgtatg cccaccttga cgatgtcctt catatggacc 120 acgccgatgg cccncgcgct nctg 144 539 431 DNA Mycobacterium tuberculosis 539 ccggctcgta tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat 60 gaccatgatt acgccaagct atttaggtga cactatagaa tactcaagct tccacatcgg 120 tatgccaaag cattgcgccg ctatcgattt cgcgctggca tcgccaaggt ggacttcttg 180 ctcagcgacg agatcccgtg gtcggatccg cggctgcggc gggctgcgac cctgcatctc 240 ggcggcaccc gtgaccagat ggcgcgcgcc gaggcagacg tcgcggcggg acgccacgcc 300 gactggccga tggtgctggc cgcgtgtccg cacgtcgccg accccggccg catcgacgaa 360 accggccgcc gtccgttctg gacctatgcc cacgtgccgt cggggtccac gctcgacgcg 420 accgagaccg t 431 540 462 DNA Mycobacterium tuberculosis 540 cgcgtccacc gcagcgtgag attggtggcg ccattcgtcg tggtgtagct gctgttggcg 60 gcgtcgccgt attgtgcggg ccagccttgt gcgggggccg cttctaccca cgagtcggca 120 cttccgcaac cgcccagctc gaccgcgatt acggcggccg caacggccgc cggaaggcgt 180 ctcgcaagcg ccttatcctt tcgcaggttc ccagatcctt ccgctacgtg ggtcgctcat 240 cggcgggccc ggccgaatga gtacaggtga gggtaaccgc tacaaatgaa gttggtcagt 300 gctggccaac tgtgtaatgg ttgcccggct cgggtcacca cgtacattct ggcaaggcgg 360 gcgagattcg gttcctcgcg tccttggccg gtggcggttc ccggttgtcc gtgggcgtgt 420 cgtgtacgtg gtgtaagtgt cgtgaactcc tcagtttggg ct 462 541 307 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 541 ctcaagcttg cgctggatct ggcggctgag cctgttcttg ggcaacatgc cgagggatcg 60 ccttttccac cacgcggtcg gggtggcgtt gcattagctc accgatggtg cgcttgtgca 120 ggccgccggg ataccccgag tgccggtaaa ccatcttgtg ctgcagtttg tcgccgctga 180 tggcgacctt gtcggcgttg atcacnatga cnaagtcacc gccatcgaca ttgggggcga 240 acgtcggctt gtgcttgccg cgcagcaggt tggccgccgc gacggcaagg cggccaanca 300 ccacgtc 307 542 333 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 542 tttgggatgg gcaaaaaggc gaagcnccgc gtggccacga acgccgggag ggacaatctc 60 gggcggctag ggcttctcgc gggaaggccc gaacgtacgg cgtttcaaca cgtcgcgtcg 120 ccctccgacc gcgaacattc ggggatggca gcaacctggt agcaccctgg ccgggcgatg 180 atctgcagcg tcgccgcggg tagtcgccgc ccgggcggct acagtctgaa acgcgatgac 240 catcgatgtg tggatgcagc atccgacgca acggttccta cacggcgata tgttcgcctc 300 gctgcgccgg tggaccggtg ggtctatccc gga 333 543 234 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 543 ctcaagcttc gtcataagac catggtgcgc tttctttcac ccgtccanag tcgggggcat 60 ccgcaccggc tcgcatcgca tcatcctccc acgacgggcc gctcatcagc ttgggccatt 120 tcaatgtact tgataccccg cgctgcgggt aggccactgc nacaattcaa acacggtgtc 180 acacggtgaa tantgtcnan atgggctctg atcaaccgtc ncaaacccgg tttc 234 544 440 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 544 gaattctgcg tgcaccgcta tgggttgcag cagcggctgg cgccgcacac cccactggcc 60 cgggtgtttt cgccccgaac ccggatcatg gtgagcgaaa aggagattcg cctgttcgat 120 gctgggattc gccaccgcga ggccatcgac cgattactcg ccaccggggt gcgagaggtg 180 ccgcagtccc gctccgtcga cgtctccgac gatccatccg gcttccgccg tcgggtggcg 240 gtagccgtcg atgaaatcgc tgccggccgc taccacaagg tgattctgtc ccgttgtgtc 300 gaagtgcctt tcgcgatcga ctttccgttg acctaccggc tggggcgtct gcacaacacc 360 ccggtgaggt cgtttttgtt gcagttgggc ggaatccgtg ctctgggtta cagccccgaa 420 ctcgtcncgg cggtgcgcgc 440 545 425 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 545 gcagttggga atcgctctgc agcaaaccan tattctgcgc gacgttcgag aggactnttt 60 gaatggacgg atctacctgc cgcgcgacga gctggaccga ttaggcgtac ncctccgcct 120 ggacgactcc ggggcactcg atgaccccga cggacggctc gcggcactgc tgcggttcan 180 tgccnaccgc gccgcanact ggtattcgct gggactgcgg ctgattccac acctcgaccg 240 ccgcagcgct gcctgctgtg cggccatgtc tggcatctac cgccgtcngc tcgccttgat 300 cagaccatcg ccggcggtcg tctaccatcg gcgaatctct ctgttcggga ctgaanaang 360 cccaagtggc ggcggcagca ctggnctctt cggtaacctg cngaccgccc attggaccgc 420 taccg 425 546 401 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 546 ttgatctgga cgtctgagac ggtgatcggn ccgaacctga attgtccggt aatgcccagc 60 gcagaaagca nggtggtggc cggggcggtg aanccggcgt cggcggcacc gtcgaagtcg 120 atgtggattg ccggaatggg gatgtccggc acggcgaagc cgtagttcgc ttgtcccgtg 180 aggcccangt ggatgggggg aaggatcgtg gtgtccggga tgataatggg gccgatgccg 240 ccggttgaag tccagtggat cgggaattcg ggaatcgtga tgccgacgtt caggccgaac 300 aggccctcca agttgcctcg ccacnagatg ccgttgctga agttgcccga catgagggcg 360 ccggtgtcca cattgcccga attggcgacg ccggtgttgg c 401 547 391 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 547 cacgtaggcg ccgtccataa atnactccgc cgcgcttcgc acatcctcgt ancgatcctt 60 ggcgagcagg tcaaccgggc gctgcccgtc naggagccgg tttttggcgt gcagccactg 120 gccgacacct cggggggtaa gcgaatccga gagcaggagg acnaggtcac gaanctgcgc 180 cagccggtcg taccgctcag ggcggatgtc gccggtccgc cacccgcgta ccgcccgatc 240 ggacacctgt atgaccgcgg cgacntcgac ctgggtgacg ccgaagggtt tcagggcatc 300 nacnatctcg ctggcctcga ccgcccggtc cagggtgacc gccatcgtgg ttcctccgca 360 acttccggtt ctactaccgt aaacgctacc g 391 548 369 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 548 cggggaacgg tcctcgcaca cctggttcgt gttgcgggaa ttactcggac ancaaaacgt 60 caagaactac gacggcagtn ggacagaana cggctccctg gtgggcgccc cgatcgagtt 120 gggaagctga tatgtgctct ggacccaagc aaggactgac attgccggcc agcgtcgacc 180 tggaaaaaga aacggtgatc accggccgcg tagtggacgg tgacggccag gccgtgggcg 240 gcgcgtttcg tgcggctgct gggacncctc cgacgagttc accgccggga ggtcgtcgcg 300 tcggccaccg ggcgaatttc cggttcttcg ccgcgccccg ggatcctggg accgcnggcg 360 cgcgctgtt 369 549 85 DNA Mycobacterium tuberculosis 549 ctcaagcttt gtccgacaag cgttcccggg cggtcagcaa gcgaacgtcg gttggcccac 60 tgcgggtcga tattgccgcc aggga 85 550 101 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 550 cgtcagcacg gcgacgtcgc gntacgccga gcagttacac aatcgctctg cagcaaacca 60 atattctgcg cgacgttcga gaggacttct tgattggact g 101 551 458 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 551 ctgcatccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca cacaggaaac 60 agctatgacc atgattacgc caagctattt aggtgacact atagaatact caagcttcgc 120 gcagcggcgg gttgacccgg ttcacgccgt catagctggc caatctggca tcgtcgatca 180 ncatgtggtg gggggtgacc tcggcggtga tcgaaatacc ctggtcctta tcccatttca 240 ggatttcgac ggtgcccgcg gccgacgcgt gacagatgtg cacccgggcg ccggcgtcac 300 gggccagcaa ggcgtcgcgg gcgacgatcg attcctcggc ggcccgcggc catcccgcca 360 ggcccagccg cgccgccatg ggtccctcgt gcgcgacggc gccgaccgtc agccggggct 420 cctcggcgtg ctgggcgatc agcacgccca aaccggtg 458 552 463 DNA Mycobacterium tuberculosis 552 ccgacgcgca ctacgtgctg gtgtccaccc gcgacccgca ccggcacgag ctacgcagct 60 accgcatcgt cgatggcgct gtcaccgagg aacctgtcaa tgtcgtcgag cagtactgaa 120 ccgttccgag aaaggccagc atgaacgtca ccgtatccat tccgaccatc ctgcggcccc 180 acaccggcgg ccagaagagt gtctcggcca gcggcgatac cttgggtgcc gtcatcagcg 240 acctggaggc cagctattcg ggcatttccg agcgcctgat ggacccgtct tccccaggta 300 agttgcaccg cttcgtgaac atctacgtca acgacgaaga cgtgcggttc tccggcggct 360 tggccaccgc gatcgctgac ggtgactcgg tcaccatcct ccccgccgtg gccggtgggt 420 gagcggacac atgacacgat acgactcact gttgcatgcc ttg 463 553 453 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 553 tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca 60 gctatgacca tgattacgcc aagctattta ggtgacacta tagaatactc aagcttgccg 120 ggagggtgca tggccgactc ggatttaccc accaaggggc gccaacgcgg tgtccgcgcc 180 gtcgagctga acgttgctgc ccgcctggag aacctggcgc tgctgcgcac cctggtcggc 240 gccatcggca ccttcgagga cctggatttc gacgccgtgg ccgacctgag gttggcggtg 300 gacgangtgt gcacccggtt gattcgctcg gccttgccgg atgccaccct gcgcctggtg 360 gtcgatccgc gaaaagacga agttgtggtg gaggcttctg ctgcctgcga cacccacgac 420 gtggtggcac gggcagcttt agctggcatt cct 453 554 466 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 554 ggaaacaccg ncgccgtcgt ggccaccaac accgcgacca gcaccgtgac ccggaccggg 60 gtgccgcgcg aaccggtctt ggccaattgc cgcggcacca agccgtcgcg cgccatggcg 120 aacagcacgc ggcattgccc gagcatcaac accatcacca ccgtggtaag cccggccagc 180 gcgccgacgg agatgatgcc gctggcccag tacaccccgt tggcctggaa cgcggtggcc 240 agatttgccg gcccgcggcc cggtacggtc cgcagttggg tgtatggaac catgcccgac 300 agcaccaccg ataccgcgac gtagagaagg gtcacgaccc ccagcgacgc gagaatccct 360 cgagggacgt ctcgttgagg acgcttggtc tcctcggcca tggtggccac gatgtcaaac 420 ccgataaacg cgaagaacac gatcgatgcc cggccagcac gccgta 466 555 466 DNA Mycobacterium tuberculosis 555 cctgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa 60 cagctatgac catgattacg ccaagctatt taggtgacac tatagaatac tcaagcttgt 120 cctcgggcgt ggcctcggcc aagaaatcgt cgacgccggc ctcctgtgca atcgccttgg 180 cggtcgccgg gttgtcaccg gtgatcatca cggtgcggat gctcattcgg cgcatttcgt 240 cgaagcgttc ccgtatgccc accttgacga tgtccttcag atggacgacg ccgatggccc 300 gcgcgctgct gttatcggtc cattccgcaa cgactagggg tgtccccccg ccggagctga 360 tgccgtcgac aatggcaccc acctcctcag tggggtggcc accgtgatcg caaaaccact 420 tcatcaccgc agccgcggca ccttgcggat ccgaacggat gcgctc 466 556 467 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 556 ttcgttcgat ggcgccgccc cggctacggt ttgacctgtg ggtgtcgaat tggggtcaaa 60 ttccgaggtc ggcgcgctaa gagtggtcat cctgcaccgc ccgggggccg aactgcgccg 120 gctcacaccg cgcaacaccg accagctgct gttcgacggc ctgccctggg tatcccgcgc 180 gcatgacgag cacgacgaat tcgccgagct gctggcttcc cgcggtgcgg aagtgctgtt 240 gctgtcggac ctgttgactg aggcactaca tcacagcggg gccgcccgca tgcaggggat 300 cgccgctgcc gtcgacgcac cgcggctggg actgccgctg gcgcaagaac tttcggccta 360 cctgcgtatc tcgacccaag cangttggcg catgtgctga cgccggcatg acttcaacga 420 actcccntcc gacacgccga acgaagtgtc gttggtgttg cgtatgc 467 557 142 DNA Mycobacterium tuberculosis 557 gcggcgagtg tggtgggtgc cgaacacgaa tccaacgacg cactggcgga gagataccac 60 ttgctgtact ggaagcacgt gctgatgatc tcccgtggaa tgtgcctcgc cgccgtctat 120 cgaaaacagt gagcatgctg cg 142 558 217 DNA Mycobacterium tuberculosis 558 caaccgcgct cggcgcgtct gggccttccg ccggctccgc cgacaattct atctctggat 60 cagcggggct ctccgggccg gcctccgcga actcaacagg ccgcgccttc cggccgaaac 120 attccctagc catatatgat cgcacctcga tacacgatct ggcggcaaca ccgcaaagcg 180 tccgacgggc ccaacctccg caattcaggt atccggg 217 559 147 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 559 gaaggtcggc gaaggtgtgg ctggntgccg atcacgaatc caatgatgca gtggtcggaa 60 gatattagcc acttgctgtt ctggagacag gtgctgatga tctcccgtgg aatgtccctc 120 gactccgtct atcgaaatct gtgaaca 147 560 177 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 560 tcctgcgctc tgggccattc tcgggtctgc cgacaattct atctctggat ctgtggggct 60 ctcttggccg gcctcngcga tctcttcang gcgcgccttc cggccgaaac attccctatc 120 catatatgat cgcacctcta tacaccgttt ggcggcaaca ccgcaaagtg tctgtcg 177 561 128 DNA Mycobacterium tuberculosis 561 agctttacgc tggcgtatca gcgttggggc cgctgccatt tcggtcgccc aacgcgttgc 60 cagctccctg cgctgtcagg gcttgcgcgc caaactggcc accgcaacaa acttggctga 120 gcttgatc 128 562 142 DNA Mycobacterium tuberculosis 562 ctctatctgg cgtcacattc gcaatcttta gattgcagat atcgataaaa tcacccgcgc 60 gacaagaccg ccatgtcatc ctttcgatgt tatttcgccg gcctggggaa agcgcaacga 120 cgttgcctac acgttccgcc gt 142 563 406 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 563 agctttncct tgcatctgca ccccgatcca cgtcagccac gtcggcgttc tccaccaaga 60 agttgcgggc attctccttg ccctggccga gctgctcgcc ctcgtaggtg aaccaggcac 120 ccgacttgcg gatgaggccc tgatccacac ccatgtcgat cagcgagccc tccctgctga 180 ttcccttgcc gtagaggatg tcgaactcgg cctgcttgaa ggggggcgaa cagttgtgca 240 cgacaacccc ttcggcgacg agggtgtgca gttcctcgac ctcgaggtcg aacgttcgtg 300 cccgccgcgt tggcagcact tctcggatca cggaatagcg ganttcttcc gccagcatgt 360 cgtgcaggaa tttgtcatcc agggcatccg cgagcgcctg cacgcg 406 564 311 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 564 actgtcnagg gaatgcttcg cagcatctac ctgcagtcgc ttgtgcataa gcggacggcc 60 cnacctgttc gtgttccggg acaccagacg cgggagcacc ggcagtacgg cgaaaggttt 120 gagcggaagg agttgcgcaa atcggggcgc cccaacaccc gtccgcaaga cgcggtcaac 180 gacctgtttc aggcgatcag ggtcaccgac tcacctgcac tgagaacaag cgatctgctg 240 atctgccaga agatggacat gaatgtccac ggcaagcctg atggcctgcc gctcttccgg 300 gaatgtttgg c 311 565 310 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 565 tgaattatga tcccgacaca actgcatcan tttagccgcg tcgngatgct atccgccgac 60 ggtttgganc nggtccgtgt cgttcgtgtt gatctcaccc gaagttgtgt ccgccgccgc 120 cggggatcta gcgaacgtgg gatcgacaat cagcgccgcc aacaaggcgg cagcggctgc 180 gaccacgcag gtgctggccg cgggcgccga tnaggtgtca gcgcgcatcg cggcgctgtt 240 tggtatgtac ggcctgnaat atccggcgat cagtgcgcaa gttgccgcgt atcaccanca 300 gtccgtgcag 310 566 326 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 566 aacggggacc ncaagaaacc attcaanaac gaggggtcgt caccaacgtc gaaaccgacg 60 gttgccagcc ggcccacgat attgcgtgct cgagggtccg ctgtaccctc accgaacgtg 120 agtcccacac cgcggaggcg ggcgactctg gcgtcgttag cagccgagct caaggtgtcc 180 cgcaccactg tctcgaatgc ttttaaccga ccggatcagc tctccgccga tctacgtgaa 240 cgagtgcttg ccacggccaa gcgactgggc tatgccggac cggatccggt ggcgcgatcg 300 ttgcggaccc gcaaagccgg tgcggt 326 567 374 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 567 agctttggag ccncnccgan ccnccggtac gccccgccac cgccgtaccc ggcacccgac 60 ccctttgagc cgttcgccgt ggccgcggtg ganctggccg acgagggact gatcgtgctg 120 ggcaaagtgg tcgatggcac gctggccgcc gatctgaagg tcggcatgga gatggagctg 180 acgaccatgc cgctgttcgc cgacnacgac ggtgtgcagc gcatcgtcta cgcgtggcgg 240 atcccatcgc gcgccggcga cnatgcanag cgcancgatg ctgaggagcg gcgccgatga 300 ggatgagcgc gccggaaccc gtttacntcc tgggtgccgg tatgcacccg tgggggaaat 360 ggggtaatga cttc 374 568 422 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 568 ttctcncatc gttcgtactn ngatgggacg ctgctgcccg aggcgatcct ggccaaccgg 60 ctctcgccgg cgctgacctt cggcggggcg aacctgaact tctttccgat gggcgcttgg 120 gccaaacgta ccggggctat cttcattcgg cgtcagacga aagatattcc cgtctaccgc 180 ttcgtattac gtgcttacgc cgcgcagctg gtgcaaaacc atgtcaacct cacctggtcg 240 atcgaagggg gtcggaccag aacgggcaag ctacggccac cggtgttcgg gatcctgcgt 300 tacatcaccg atgcggtcga cgaaatcgac ggtcccgaag tgtatttggt gccgacctcg 360 atcgtgtacg aacagctgca cgaagtggaa gccatgacca ccgaagccta tggcgccgtg 420 aa 422 569 300 DNA Mycobacterium tuberculosis 569 ttcttccggg taccgctgat cggcggcacc atcacgcacc cggtgcaggg cgaggcggcc 60 gccggtgtgg tgttgctacg gccggccagc ccgggtaccg gtgtgatcgc cggtggtgcg 120 gcccgcgcgg tgctggaatg tgcgggggtg cacgacatct tggccaagtc gctgggcagt 180 gacaacgcga tcaatgtggt gcacgccacc gtggccgcgc tcaagctgct gcaccgtccg 240 gaggaggtgg cggcgcgccg cggtttgcca atagaagacg tccccccggc cgggatgctg 300 570 343 DNA Mycobacterium tuberculosis 570 gtcgaaagtg accatctcta ccttgagtgc cataccgccc gaccctatgc ctcggatagc 60 tcggcggaaa gaaacgcttg cagtgccgcc gaataggcgg ctacgtcgtg agcgcccatc 120 aactctcgcg cggagtgcat cgccagctgg gcggcgccga cgtcgaccgt ggggattccg 180 gtgcgcgccg cggccaacgg cccgatcgtc gacccgcacg gcagatcggc gcgatgttcg 240 taacgctgca taggcactcc cgcgcgctgg caggccagtt gcgaaacgcc cccgccgggt 300 gccttccgtc ggttggcttt accgcaaatt tggggttgcc cct 343 571 220 DNA Mycobacterium tuberculosis 571 aaagccacgg aaacgattgc ctactgccga atcggggaac ggtcctcgca cacctggttc 60 gtgttgcggg aattactcgg acaccaaaac gtcaagaact acgacggcag ttggacagaa 120 tacggctccc tggtgggcgc cccgatcgag ttgggaaact gatatgtgct ctggacccaa 180 gcaaggactg acattgccgg ccagcgtcta cctggaaaaa 220 572 254 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 572 tttcgccacc gcnaggtcgt gcgcgttcca gaaaagcgtg gtttcgccgg gcgcgaggat 60 tcgacggtcc aactgaccag ccggtcccgc cacccgttag gcaggatcgc ggtgtctata 120 tgttcgccct cggcataaac gccattgctg cggtgaaaat cggacatctc gccgattgcc 180 acgtctacat gatccgcttt gtcccgcgcc gggtcgttga caaacgcgat gtcngcctcc 240 tgggaagcgg tggc 254 573 329 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 573 tcgccaagtg gattcgtgct caccnacgag atccgtggtc ggatccgcng ctgcggcggg 60 ctgcgaccct gcatctcggc ggcacccgtg accaaatggc gcgcgccgaa gcagacgtct 120 cggcgggacg ccacgccgac tggccgatgg tgctggccgc gtgtccgcnc gtcnccgacc 180 ccggccgcat cnaccaaacc ggccgccgtc cgttctggac ctatcccacg tgccntcggg 240 gtccacgctc gacgcgaccg anaacgtaac cagcgtcctc gancggttcg cccccggctt 300 ccgtgacatc gtggtggcgg ccgcgccgt 329 574 297 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 574 gtaccgtcac catgatcgcc cccatcggca tcggtgagct gatagatccc agccggtttc 60 gccaaccccg gagcgatctt ggcgcgctgc tngtngtcnc tganacntag ccaccaacag 120 agcccggtgt gcgacaagan gactgatcgg atctctccgg acacntcgag ggggtcntca 180 ggagnccggg cgccaccccg aggtaagcct ccgcccagcc tcacaccgcg accgggtatc 240 ncaagtcgcg caataanccc accacctcct cggaccccac gttgtatgcg gctgggt 297 575 401 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 575 atactcaagc ttagacctca ctgatgtggc gggacgcggg agataaccgc ggttcgagcc 60 gttcaacagt ggtggttccc acaccagttg tttgcctttg cgaagtaaag cgattcgatt 120 tgctcgaaaa gagggctggc tgctcgtgag ggacatccat ggccgatacc tcagcgatct 180 caacggtcaa gcgactgcat gtttggcgca aggtatcgct aagcataggt tcgtgacgga 240 tttgacagca agagctttcc aaagattgct gtccacatan tgattcgcat ctctacacct 300 cttcgccggt gctgtcaaga gccattcgaa tcagttatct cgctcgtgct tggaanaaat 360 tttcccagcc tgcgttggac aaaccgcgtc gccaaagcgg t 401 576 453 DNA Mycobacterium tuberculosis 576 agcttcccga gaaacagtgc attccctaag cagcccgttg tcacgccgat gagtgaagag 60 tgcacgcaat cgccggaatc cggcaaagcc ctgcacaagc gaaatcaacc cggaggctga 120 caaggcaacg tcggtgatcc gtaccgcctg gttggacaaa cggcagaagg cggcctcgtc 180 cggtccatct acgccgagca cactggtgat agcgcgcatc ggcatcggtg cggccacggt 240 ggagacgacg tccgcgggcg tctgggtcag taacccgccg accagttctc gggcaagctg 300 gtcgaccatc gggcgccacg tctccaacgc gccacgcgcc atacctggtg ccagttgctt 360 gcgcatccgg gtgtgcgccg gcggatcgga cgtcgcagaa acgcagccac cccgtgagaa 420 gtgacccacg gcgctggaca cgtgtctggt tac 453 577 474 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 577 cggccgggat gtgcgcaatg gcaggttgtc gcccggcttg atgtcggcgt tagcgccgga 60 ttccaccaca tccccttgcg aaagtccgtt gggtgcaatg atgtancgct tctccccatc 120 gagatagtgg agcaacgcaa tccgtgcggt acggttcggg tcgtactcga tgtgcgcgac 180 cttggcgttg acaccatctt tgtcatggcg gcgaaagtcg atcatccggt aagcgcgctt 240 atgaccgccg cctttgtgcc nggtggtaat ccggccatgc gcgttgcgtc caccgcgacc 300 gtgcagcggg cgcaccagcg acntctccgg ggttgaccgg gtgatctcgg cgaaatcaga 360 tacgctggcg ccgcgacgac caggcgtcgt gggcttgtac ttgcgaattg ccatggtcta 420 atcaggtctt tctctcacct ctcgtcgccg ggctagggcg cattgcctgc tcct 474 578 357 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 578 tagcggtgta accaactccc gggtcaccac ccgcaaacct cttgcggcaa cagcaccgtc 60 gacgcgtcaa ccgggctgcc cggaatcctg tggatgggca tcgagtgcat ggtcacgacg 120 tccccgacgc ggccggtggc aacgacaagt ggcccggatg caccacaaat gacggccgca 180 caccggtggg gacggccagc acgagagccg tgtcgccgaa gtcgacgcta atgccgtagg 240 cattggccgt cacaacaggc gacgccccgc gtaccaccga gtccacggng gttgggcggt 300 ctcctcggcc aaccaggcgt gaacccggcg gatccgaatg cagcaagacc cgtgggc 357 579 269 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 579 ccattggtcg gtgtgcgcat accantacna cgcgccgggc acctgacgcg gcggccgcaa 60 ccattcggtg gccatcgcca tcgtctgcca cccggtcaac ggacgcacct tctcctggcc 120 gacctagtgc gcccacccgc cgccgttgcg tcccatcgat ccggtcaaca tgagcagcgc 180 caacaccgag cggtacatga catctgctgt ggaaccagtg acanattccg ccgcccatga 240 tgatcntcga ccgtcctccg gattcggtc 269 580 272 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 580 gccggcctgg tcaaaggggc gtccgaagga nccgggctgg gtaacaagtt cctggctcat 60 atccgcgaat gcgacgccat ttgtcaggtg gtgcgggtgt tcgtcgacga cnacgtgact 120 catgtcaccg gacgggtcga tccccagtcc gacattgagg tcgtcgagac cgagctgatc 180 ctggcagatc tgcaaaccct ggagcgggcc acgggccggc tggagaanga agcncgcacc 240 aacaaggcgc gcaagccggt ctacgacccg gc 272 581 373 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 581 gatccactga ccacgatgac atatcgaaat gctcgacgat tccgatggcg atcaaggcca 60 cgatgccctg gccgttgggc ggtatctggt ggatggtgta cccgcggtag gttcccgtga 120 tcgtgtcgac ccagtccacg cgatgggcgg cgaggtcgtc ggcacgcatc accccgccgt 180 ntgccgccga gtgcgcctcg agtttggcgg ccagctctcc ccggtagaac tctcaccgtt 240 ggtcgccgcg atcttctcta ncgtcgccgc gtggtcagga aaggtaaaca gctcaccggg 300 tttcggcgct cgtccgccgg gcatgaacgc atctgcgaat ccgggctggg atgcgaacaa 360 cggacctgtg ccg 373 582 314 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 582 tctactgccg aatcggggaa cggtcctcgc ccaccnggtt cgtgttgccg gaattactca 60 ggacaccgaa acgtcgagaa ctacgagcgg agttggacan aataccgctc ccnggtgggc 120 gcccccatcg anttgggaag cngaaatgtg ctctggaccc cacccaagaa tgacattgcc 180 ggccgccctc caactggaaa tagaaacngt gatcacccgc cgcgttcttg gaaggaatgg 240 catgccctgg gccgggcgtt ccttccgctg ccggactcct cccaccaatt caccgccgaa 300 ggcgtcccgt ctgc 314 583 135 DNA Mycobacterium tuberculosis 583 atactcaagc ttctgtcacc gaaatcccgc atgggataac gggtttagat ttcgacaacg 60 ggaccgtgtt tctcaacaag ccggtcatca gctgggccgg cgacaacggt atctacttca 120 cccgctttcg cccgt 135 584 221 DNA Mycobacterium tuberculosis 584 ctggctcaag cgctcggcgc gcaggtgaac tcggaccggc tcgacgtcgc cgaacgcgag 60 gcggtgctgg cccacgccga cgccgtcgtc gcacatatcg gcaccgtgca caagtctaca 120 acaacgccgg catcgcgtac aacggcaacg tcgacaagtc ggagttcaag gacatcgagc 180 gcatcatcga cgtcgacttc tggggcgtcc tccacgggcc c 221 585 70 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 585 ccgccctccg cattatgggt caagaaccat cgggtcggac ttctgggctt ccaacgctcg 60 cgccgtcccn 70 586 241 DNA Mycobacterium tuberculosis 586 ccgtggcact gtcagacata tgcgccgctc ctcctcatcg ctgcgctcgg catcgtcgcc 60 ggcggtcatg gcgtcaccct acccaagccg aacgcgaaac gagaacgtgt tccattatta 120 gggtgtgagc accaatacca gattgctcac caggaactca cgcagcaccg ggacggatgt 180 cggccaccac gcccatctgg ggtggtagcg gggaaatacc gctaacgcgg ctccggtgcc 240 g 241 587 492 DNA Mycobacterium tuberculosis 587 tactcaagct tgtccaaata tcgaagcgtc gggtcgcgag gctcggtcgg cagctccagc 60 aaaacccgct ccacccctag atgccggtat ccctcaaggt ctttatccgc cgcttcaccc 120 cactggcaca cggtcaccgg cacgtcgccc ccggccatgg cgcgcaaccg ctgaagcgga 180 cccgacagcc gctgcggtga tggactgatc gcgatccacc cggcattgag ccgggctatc 240 cgcgggaagt tcgccggtcc cccgcccaca tacagcggag gatagggctt tgtcaccggc 300 ttcggccagc agtagatcgg atcgaagtcc acatatgtcc catggaattc cgcctgctcc 360 tgcgttcaga tctcgattat cgcgcgcaac cgctcatcga tcacacgtcc gcgcaccgca 420 gggtccacac catggttggc gacttcttcg cgcaaccagc cacacccacg ccgaaacgaa 480 accgtccctg cg 492 588 313 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 588 caggcatgca agcttggcca actcctcatc ggacttgaag gtgccgtcct cgttggcggc 60 cctgctccac ggcacgttga tggcaccagg aatgtgtccg ggccgctggc tttgttcctg 120 cggcaggtgc gcgggggcca ggatcttgcc ggagaactcg tcgggagagc gcacgtcgat 180 gaggttcttg acgttgatgg ccgccaggac ctcgtcgcgg aatgcccgaa tcgtgttatc 240 cggcggggan gcggtgtagg aagtcaccgg ccggctgacc gggtcgctgg acagcgggcg 300 tccgtcgagc tcc 313 589 305 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 589 atactcaagc ttcaaaacag gcctgttgtg ggcgcacccg gctcgccgag ttctgcacgc 60 accgcctcaa gtgcggcccg caccgccggc atctcccggt cacgcagggc cgcggcccgc 120 gccgcagcga cggcgtgttc gcgcagttcg ccgtcaatga tgctgacctg atcggccacc 180 cgggcggtct cggcgtcgtc ccgttcacta atcgcggtgc tcagcagcgt ctcgacagcc 240 accacccgag tggagaccag atgcnccacc acggaccgca gcgatgccag tcacctcacc 300 cgtcc 305 590 394 DNA Mycobacterium tuberculosis 590 caggcatgca agctttgcag ttgctgagta atgtcggcca acgtcaccac aatcgcgatg 60 aattcaatca tgccgcccag ggcggccaac ccaatggtgg ccgcgagcgg cagctcgatc 120 gcagcgcgga ggttgccggc cgccagttga ttcacgaaca gggtgaggtc ataggcgggc 180 aggatagtga cgaaggcaag acctagatct gccgtcggaa gaagaatcga gtatccggtc 240 gacacaacgg aagcgaaagt gtccgcgatg ttgatgagcg tcgccggttg tggcggcggt 300 ggcggcggta gcaccgtccg cacataccgc gggaacgcgg gcatccgaat ttggggcagg 360 gtgttcaagg cggctggcaa ctcaccatga atct 394 591 457 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 591 ccggctcgta tgttgtgtgg aattgtgacc ggataacaat ttcacacagg aaacagctat 60 gaccatgatt acgccaagct atttaggtga cactatagaa tactcaagct tggccgcagg 120 gccgagtcga ttggtcgcgg tcgcctcgac agttagctta tgcaatgcta acttcggggc 180 aaagttcagg cggatcggcc gatggcgggc gtaggtgaag gagacagcgg aggcgtggag 240 cgtgatgaca ttggcatggt ggccgcttcc cccgtcgcgt ctcgggtaaa tggcaaggta 300 gacgctgacg tcgtcggtcg atttgccacc tgctgccgtg ccctgggcat cgcggtttac 360 cagcgtaaac gtccgccgga cctggctgcc gcccggtctg gtttcgccgc gctgacccgc 420 gtcgcccatg acagtgcgac cctgnaccgg gctggcc 457 592 438 DNA Mycobacterium tuberculosis 592 gtgtgctgtc aattcagagc tgagcctgat gcactcaact tactgagcat gctaacgctg 60 gtcgtgcggg tcttgttccc gcgtgtcggc agggcacacg ctcggggcgt agctgggaga 120 ggccccggtc aagcccggag agcagtgctc agtccgccag cttgaccgac tttcgatgag 180 aacgcgcttc tcgccgtatt gaactggcgt gctgacggtc gctgagcagc gctcgccgag 240 tgcggccgct gattctttca tcgagccagg aggcgcattc gtgttcggcc gcctgcgggt 300 cggccccatc gtcgacgcga tccgtcaccc actcctcgat caggtctgcc tcatcgaacg 360 ggccaacggt gctgtcggag taagtgtgcg tgggcacgcg agccgggtgc tgtggtacac 420 ccaccgttgc atgaacaa 438 593 220 DNA Mycobacterium tuberculosis 593 atactcaagc ttcaccaggc gccggcgggc cgcggcgcca agccaggcag ccgcgctcgg 60 cgcgtcgggg ccttccgccg gctcggccga cagttcgatc tctggatcgg cggggctctc 120 cgggccggcc tcggcgacct cagcgggccg cgccttccgg ccgaaccatt ccctagccat 180 agataaccgc acctcaatgc acggtttggc ggcaacccgg 220 594 266 DNA Mycobacterium tuberculosis 594 agcttccgtc acgacccgcc ctcgccggtg ccggcgccat cggtcatcgg atctcatgac 60 gacgtcacgt aggcccgcta gccgcgagcg ggcgcggtca actggcgagg cggcggcgac 120 gtgactgagc tggccgagct ggaccggttc accgcggaac taccgttctc gctcgacgac 180 tttcagcagc gggcttgcag cgcgctggaa cgcggccacg gtgttgctgg tgtgcgcgcc 240 gaccggcgct ggcaagacgg tggtcg 266 595 105 DNA Mycobacterium tuberculosis 595 atactcaagc ttgccgggac cgcggaacag aaccggcggt tcctaccgcg gtgtgcggcc 60 ggcgcgatat cggcctcccg actaaccgaa cccgatgtgg gctcc 105 596 141 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 596 acgttggctc tgccggaacg tatttccagc ggcacgcatt cggcgtgggt gccgggcgcc 60 gagttgcgtc gctgggatca cgcagcagtc gccggcggct gccgtcgggc tatgaattgc 120 accgagccgg aaaatccnca c 141 597 234 DNA Mycobacterium tuberculosis 597 atactcaagc ttgtcgtatt ccgtggcact gtcagacata tgcgccgctc ctcctcatcg 60 ctgcgctcgg catcgtcgcc ggcggtcatg gcgtcaccct acccaagccg aacgcgaaac 120 gagaacgtgt tccattatta gggtgtgagc accaatacca gattgctcac caggaactca 180 cgcagcaccg ggacggatgt cagccaccac ccccatctgg ggtggtagcg ggga 234 598 184 DNA Mycobacterium tuberculosis 598 cgttggtagc ccgatatgca tagtgtatct tactgaacat gatttccatt atggagcccg 60 gggtgccggc agcgcgaacg gtgcgccgtc agacgcgggc ggcactgacc agggtgttgc 120 gggcgaacat cggcccggct tcggattccg gtccgggtac cgggcgaccc accgcttcga 180 ggta 184 599 351 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 599 atactcaagc ttggccaact cctcatcgga cttgaaggtg ccgtcctcgt tggcggccct 60 gctccacggc acgttgatgg caccaggaat gtgtccgggc cgctggcttt gttcctgcgg 120 caggtgcgcg ggggccatga tcttgccgga aaactcgtcg ggagagcgca cgtcgatgag 180 gttcttgacg ttgatggccg ccaggacctc gtcgcggaat gcccgaatcg tgttatccgg 240 cggggaggcg gtgtatgagg tcaccggccg gctgaccggg tcgctggaca gcgggcgtcc 300 gtccagctcc cacttcttgc gggcgccgtc caacnacttg acttctcctg g 351 600 438 DNA Mycobacterium tuberculosis 600 atatcttaag cgtcgggtcc cgaggctcgg tcggcagctc cagcaaaacc cgctccaccc 60 ctagatgccg gtatccctca aggtctttag ccgccgcttc accccactgg cacacggtca 120 ccggcacgtc gcccccggcc atggcgcgca accgctgaag cggacccgac agccgctgcg 180 gtgatggact gatcgcgatc cacccggcat tgagccgggc tatccgcggg aagttcgccg 240 gtcccccgcc cacatacagc ggaggatagg gctttgtcac cggcttcggc cagcagtaga 300 tcggatcgaa gtccacatat gtcccatgga attccgcctg ctcctgcgtc cagatctcga 360 ttatcgcgcg caaccgctca tcgatcacac gtccgcgcac cgcagggtcc acaccatggt 420 tggcgacttc ttcgcgca 438 601 410 DNA Mycobacterium tuberculosis 601 atactcaagc ttgtcgcggt aaacccgcag cagggcggtg ggtgcggtgt caaaaacaac 60 cacacttctt tgcggttcgg tgatctcgac accggccgcg agccgaccac catgcgcgcg 120 taaatcggcg atcagcgcgt cggctatcgc ctgggtgccg cccaccggaa tcggccagcc 180 gaccgaatgg gccagcgttg ccagcatcag tccggcgccg gccgacacca gtgacggcaa 240 cggtgaaatc gcgtgggcgg caacgccggt gaacaacgcg cgggcatcct cgcccgccag 300 cgaccgccag gcaggggtgc cctgggccag catccgcagc ccgagacgca ggaccgagcc 360 cagtgcagta ggcaaagacc gcttgtcgga gacatgaact ccacgaccgt 410 602 456 DNA Mycobacterium tuberculosis 602 agcttattga accgcgggtc gcaggcaaag tggacctcat aacgactcgg gtccagcgac 60 cgcgccaaca cgaacggccg gacgacgtgg gccagggtcg cggcctcccc tacaaacagg 120 atccgttgcc tgcgagcgac aggctccggt gcggcgttgg gcgccgtgct cgtcccagcg 180 tccggtcccg ggtcgccggc gacgcttgtt tcctccatac tcgcccccta atctcgaggc 240 agcccgtacc cgcaggcaac ctcccaaaaa tgcaatcccc caaaatgcaa tgcgtcgagc 300 tatttctcac accgaccgct agttgcggat cagaaatccg ttgggcgcgg aagtccagcc 360 gaatttgttc tcccgctccg catcatgctt gtaatcgttt ggaaattcat cctcatatgc 420 ctcgatcgct tcatagggtc caggccaaac cgggca 456 603 217 DNA Mycobacterium tuberculosis 603 cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac aggaaacagc 60 tatgaccatg attacgccaa gctatttagg tgacactata gaatactcaa gcttggccac 120 ctcgcggtgt gtggtggaac ccatctgagc agtgtgccaa accggggcag acagctccca 180 attgacgtga gcccgctcac ttgctgggta agcgtcg 217 604 478 DNA Mycobacterium tuberculosis 604 tagcgccccc tcccgggcgg agctccacgg cgtggatcaa ggtaccggcc gggatgttgc 60 gcaatggcag gttgttgccc ggcttgatgt cggcgttagc gccggattcc accacatccc 120 cttgcgaaag tccgttgggt gcaatgatgt agcgcttctc cccatcgaga tagtggagca 180 acgcaatccg tgcggtacgg ttcgggtcgt actcgatgtg cgcgaccttg gcgttgacac 240 catctttgtc attgcggcga aagtcgatca tccggtaagc gcgcttatga ccgccgcctt 300 tgtgccgggt ggtaatccgg ccatgcgcgt tgcgtccacc gcgaccgtgc agcgggcgca 360 ccagcgactt ctccggggtt gaccgggtga tctcggcgaa atcagatacg ctggcgccgc 420 gacgaccaag cgtcgtgggc ttgttcttgc gaattgcatg tctaatcagg tctttctc 478 605 459 DNA Mycobacterium tuberculosis 605 tgaaactata taatactcaa gcttgccaaa gaagacctcg tcgaccaagc aggacgcgac 60 cgtcgaggtg gcgatccggc ttggcgtcga cccgcgtaag gcaaaccaga tggttcgcgg 120 cacggtcaac ctgccacacg gcactggtaa gactgcccgc gtcgcggtat tcgcggttgg 180 tgaaaaggcc gatgctgccg ttgccgcggg ggcggatgtt gtcgggagtg acgatctgat 240 cgaaaggatt cagggcggct ggctggaatt cgatgccgcg atcgcgacac cggatcagat 300 ggccaaagtc ggtcgcatcg ctcgggtgct gggtccgcgc ggcctgatgc ccaacccgaa 360 aaccggcacc gtcaccgccg acgtcgccaa ggccgtcgcg gacatcaagg gcggcaagat 420 caacttccgg gttgacaagc aggccaacct gcacttctc 459 606 464 DNA Mycobacterium tuberculosis 606 gctgagctcc acggcgtgga tcaaggtacc ggccgggatg ttgcgcaatg gcaggttgtt 60 gcccggcttg atgtcggcgt tagcgccgga ttccaccaca tccccttgcg aaagtccgtt 120 gggtgcaatg atgtagcgct tctccccatc gagatagtgg agcaacgcaa tccgtgcggt 180 acggttcggg tcgtactcga tgtgcgcgac cttggcgttg acaccatctt tgtcattgcg 240 gcgaaagtcg atcatccggt aagcgcgctt atgaccgccg cctttgtgcc gggtggtaat 300 ccggccatgc gcgttgcgtc caccgcgacc gtgcagcggg cgcaccagcg acttctccgg 360 ggttgaccgg gtgatctcgg cgaaatcaga tacgctggcg ccgcgacgac caggcgtcgt 420 gggcttgtac ttgcgaattg ccatgtctaa tcaggtcttt ctct 464 607 205 DNA Mycobacterium tuberculosis 607 atactcaagc ttgttggtga cctcgccggc gaacagttct cgcacgattt ccggattagc 60 gggactggtc accagttggg tatgcgggaa ggcgctgacg ttcgccgcga ttagctgttt 120 gatggacgcg gcggtgatgt cctgatcacg gaactggctg taatagccca gggtcgccac 180 gcttccatcc gggcccggac ccggc 205 608 244 DNA Mycobacterium tuberculosis 608 gatgatcgcc ggtgccaccc cgatccgtgc ctcggtcagc gcgaacgtgc tttccggtcc 60 ggcgaccacc atgtcgcacg caccgaccag gccgaacccg ccggcccgca catgcccgtt 120 gatggcgccg accaccggca gcggcgactc gacgatggcg cgcaacagcg ccgtcatttc 180 ccgcgcccgc gccaccgcca tccggtacgg atcaccacca cctccgccgg cctcgctgag 240 gtcc 244 609 289 DNA Mycobacterium tuberculosis 609 atactcaagc ttgccgcaat cgaaaccaac ctgtttgtgc cgcaagaaat tacgccgtgg 60 cccggcgccg atcaagaaac gccccggcgc gcggcggtgt cgtcgtatgg catgacgggc 120 accaatgtgc acgccattgt cgagcaggca ccggtgccag cccccgaatc cggtgcacca 180 ggcgacaccc cggccacacc cggtatcgac ggcgcgctgc tgttcgcgct gtcggccagc 240 tcgcaggacg cgctgcggca aaccgccgcg cggctggccg attgggtct 289 610 282 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 610 ttggcgggtt ggccacanca ncccgccggt gacggcgacg atgctgggct ggttgcggcc 60 ctgcgccacc gcggcttgca tgctggttgg ctgtcttggg acgatcccga aatagtccac 120 gcggatctgg tgattttgcg ggctacccgc gattaccccg cgcggctcga cgagtttttg 180 gcctggacta cccgcgtggc caatctgctg aactcgcggc cggtggtggc ctggaatgtc 240 cancgccgtt cacctacgtg accttgatgg gatccggggg nt 282 611 312 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 611 ncgtggacac cggtgtcgan cgccaccagc cgcatgtctg cangtcnatt ccgtcctcgg 60 caacatcttg aatgccgagc agcgcctggg cgtgatcggc aaccggggat gaccgctcgc 120 cgatccgctc gacaatcccg gcggcacgtg acatgccggc ggacggctcg acgagctgga 180 acttcagcga cgacgatccg gaattgatca ccagcacggt gctactcatg gacccctgcg 240 cctgaatccc gtgatggcca cggtgttgac tattcgtcga cagtgcaccc gagatagtct 300 tcacggctgc gt 312 612 349 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 612 catgtattgc cgtgctcacg gcgccacgct cgatggtttc tcgaagtctc cgggctggtg 60 tacagcttct cgttgatctc gttcgccacg ccgtcctctt cccgccgacg acccgatctc 120 gatctccana atgatcttgg cggccgccgc cgccttgagc agctcctggg cgatggccag 180 gttctcatcg atgggcactg ccgaccgtcc cacatgtgcg acggaacaaa gatgtcacct 240 tgctcacgcg tgcgcnagat cncanaaggg ccggacatac tgtcnacttg tccttgggca 300 gtggtccgtg tcagcccacg tgacgggtac ttggcgcgat aacgtggtg 349 613 350 DNA Mycobacterium tuberculosis 613 gccaccacga cccggccgta actctgctca cggaaatgcg gccaggccgc gcgtagcacg 60 tggtatccgc cataaaggtg caccttaagc acggcgtccc aattctcgaa cgacatcttg 120 tggaaggtgc cgtcgcgcaa gatcccggcg ttgctcacca caccgtgcac ggcgccgaat 180 tcgtcaagcg cggtcttgat gatgttcgct gcgccgtcct cggtggcgac gctgtcctta 240 gttggcgacc gcccggcccc ccttgtcgcg aatctcggcg acgacctcat cggccatcgc 300 cgaacggcgc ccgtgcccgt cgcgggcgcc accgaggtcg ttgaccacga 350 614 126 DNA Mycobacterium tuberculosis 614 caggcatgca acctttgtcc acacggcgtc tactccgtgc aaggtccgac cgcttccacg 60 tcccgccgtg acggtgctcc atctccctca gcaacgcgtg aagtggtccg atcccgcggc 120 ttcagg 126 615 395 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 615 gttgagacgc aaccagcgca caacgacgat ttggcgtagc ggcggacgtc tgctcgattc 60 gatcacgtcg cgctcgcatc gagcatggcc cgcgacgcta cacgatcgcc gtcgtcgatg 120 acacgaccga gccgtacgcc ggccgtaagc cgcgccagga ttcggcgaaa aacgtctacg 180 tggcgggtgt actgggtgtc gaatgattcg tggggtgcgt atgcgtcctg caatcgtcga 240 catagatccg tcgccgcatc gcgtcgacaa ctccgggtga gtggaataca cttgccgatc 300 acgcgacgtg cgcggatcga tgccgaccga aatacgacca catggctctt gttgcncagt 360 gttggcggca tcaaataccc tcagtgccgt ccgac 395 616 371 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 616 ttnccgcctt nacgcctact ccnagacgat gctcgacgcg tgtgagcaca cggcgctgct 60 gtagacggca cggcgcagct ggatcgcgct tggtgcaccc aagcctctac gcgcgtcgct 120 gcgtcgtcat cgggtaccga acatattccg gtcgttgcgc agagtgtgca tgtgcggctc 180 ttgtgaacga acatagcaaa gcgtatatgt ctgtggcggc tctgcagata tcgcgataat 240 acgtatatac ataaggtggc gcgcgatcta tcggtatatc cgttatggcg gacgtgcgtg 300 agcgtgagtc gcggcgcatc gcgcacttcg cgatcgcgtg actggtcctc gcgactgcgc 360 gcatgcgtag c 371 617 423 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 617 ggtgatgacg cacttgcttc gaatgagtca ttgactactc ccgtggttgt cctgcgatgg 60 tggagtgccg cgcagccttg cccgangtcg cgatcgcgtc gcgggcttcg gggagcagac 120 tgacctgcag atggaagtcg tgccacatgc ccgcgaacgg cgagctcgat gcttgttttc 180 gaagngcgca ngcggtttcg atcttgtccg cgtcaacgca gatcggatct cgccgcggtc 240 tgcatgacga tgggcgcagg cccgctcatg tcccgtagac ggggagatac gggcagccgc 300 ggatcgagac ctacgtagcg cggcgcccat cgtgccatcg acgaagaatg acggatcgcg 360 cagcgccgtc gcgtcgcttc gatgtcacgc gagatcgcca cggcagatca gcgatgcgcg 420 ggc 423 618 354 DNA Mycobacterium tuberculosis 618 cggtacgccg gcaacaaacg ccttgtgacg agcgcgtccg agcggtcatc ggcctccacc 60 gtcatgcaca gctccttctc caggtctacg ccgacgtcgc ggtccacatt ggtgagcttg 120 gcgaatgcct cggcaacctc gtcgaaatgc gcctccgcgt ccgcatcgaa ggtcgccatg 180 tcaaagatca actcgacgta gtagctagtt accgcatcag gtcagtgttt gctggcctcg 240 gagtccggcc gaacaatggc catttcccgc gactctagaa tccagtcatc gtctcggtga 300 cgacgccttg ccgatcacat agctcgaccg gatcggagag aatctggttc tcgt 354 619 128 DNA Mycobacterium tuberculosis 619 atactcaagc ttaagcgcag cagtaccggc ggtgcctggg catcccagca aaacggggag 60 ctcaacgaac gattcctgaa cgaagggtcg tccaccaacc tccaaaccga acggttgcca 120 gccccggc 128 620 295 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 620 gcaagtccgc tcaatgtggt tgtgatcaca ngactacgtc gcctcaatca gctcaaacgt 60 caccccgtgg cgtgctgcgc agcatgaagg tcggcgcccg cacgatgtgg gcgaagcaac 120 aggtaataac tggtcggcat gggtcaaccc tcattgggcc gttgcggatc gggtgcacgc 180 ccggagtgcc ggtcgaactc aacaccgcct tcaccgatct tttcgtcgaa aatggcggtc 240 gtgtcggggt atacgtccgc gatcccacga ggcggaatcc gctgagccgc actga 295 621 361 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 621 atactcaagc ttcgcgccct caagcggctg aaggtggttc cggcgtncca acngtcgggc 60 aactcgccga tgggcatggt gctcgacncc gtcccggtga tcccgccgga gctgcgcccg 120 atggtgcagc tcgacggcgg ccggttcgcc ncgtccgact tgaacgacct gtaccgcagg 180 gtgatcaacc gcnacnncnn gntgaaaagg ctgatcgatc tgggtgcgcc ggaaatcatc 240 gtcaacaacn agaancggat gctgcnggaa tccgtggacg cgctgttcga caatggccgc 300 cgcggccggc ccgtcaccgg gccgggcaac cgtccgctca agtcgctttc cgatctgctc 360 a 361 622 361 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 622 tgcgcatggc agttgttgcc ggcttgagtc gcgttagcgc ggattccacc acatcccttg 60 cgaagtcgtg ggtgcaatga tgtagcgctt ctcccatcga gatagtggag caacgcaatc 120 cgtgcgtacg ttgggtcgta ctcgagtgcg cancttggcg ttgacaccat ctttgtcatt 180 gcggcgaagt cgatcatccg gtaagcgcgc ttatcgacgc cgcctctgtg ccgggtggta 240 atccggccat gcgcttgcgt ccaccgcgac gtgcagcggg cgcacaccga cttctccggg 300 tgacgggtga tctcggcgaa tcagaacctg gcgcgcgaca cagcgtcgtg gctgtacttg 360 c 361 623 312 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 623 tgggtgatca gatactggct agttggtcgg gtggggtgat cgaagatcgc ggtggccggc 60 agcgttactg cggtgacgct gttaagcggt tacgtactcc acggcactca angaattana 120 tcccgaatcg gcaaaccctg gccagcgtcg agtccgcagc gccgtcgcgc cccccaccgc 180 tgcggcatgc tcacatacca cctcgatcgc tgcgggagtt gctcgtcggc cgaccgaccg 240 gccagccggg cggcaaaccg gaggacccaa gattcagcac caccatcgct agcccgatct 300 ggccgcgcgt gg 312 624 454 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 624 tcgtagcggt tgcgaccant ccgcggacag ctccgccacg cgacgggtcg ggatcaccgc 60 ggtcaaacca ccgagcggcg aggatctctg gccgtcgacg tgaccgcgca cggccgcggt 120 gatggccagt cccgaccgcc gttccacttg gcgtacgcgc tggatgtgtt gtgccgcaac 180 ggaatcccac ctcaattatg acctcgttgt gggcgagcgc ggtatcgtac gcccgaccag 240 gaatcgtcga tgctatctca cgtcaccgaa ggcctctccc agcacaccgc atccagaacg 300 tgcacacngt cgacatgtct cggcggatcc gcctgcagaa cgaacgccan gtgcgctgtg 360 cgacacgggt cgcgatcacc gctcgcacgc ggagatcggc acacgcgcag cgcatcgatc 420 ataatctctc gatgcggtct ccaccaccga acag 454 625 366 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 625 atactcaagc ttcgctgagg tggtggggca cgatcacgtc accgcaccgc tgtcggtggc 60 gctggatgcc ggccggatca accacgcgta cctgttctct gggccgcgtg gctgcggaaa 120 gacgtcgtca gcgcgtatcc tggcncggtc gttgaactgt gcgcagggcc ctaccgccaa 180 cccgtgcggg gtctgcgaat cctgcgtttc gttggcgccc aacgcccccg gcagcatcga 240 cgtggtagag ctggatgccg ccagccacgg cggcgtggac gacacccgcg agctgcggga 300 ccgcgcgttc tatgcgccgg tccactcacg gtaccgggta tttatcgtcg acgaggcgca 360 catggt 366 626 363 DNA Mycobacterium tuberculosis 626 gcactcacgc tggtacaaga ccttcacaaa atctgaaatc ctgacccgat acttgaacct 60 ggtctcgttc ggcaataact cgttcggcgt gcaggacgcg gcgcaaacgt acttcggcat 120 caacgcgtcc gacctgaatt ggcagcaagc ggcgctgctg gccggcatgg tgcaatcgac 180 cagcacgctc aacccgtaca ccaaccccga cggcgcgctg gcccggcgga acgtggtcct 240 cgacaccatg atcgagaacc ttcccgggga ggcggaggcg ttgcgtgccg ccaaggccga 300 tccgctgggg gtactgccgc agcccaatga gttgccgcgc ggctgcatcg cggccggcga 360 ccg 363 627 367 DNA Mycobacterium tuberculosis 627 atactcaagc ttgtataaaa agatcggtga gcgcatcgat tcgctccgcc gggtttgccg 60 ctgcggcggc ggagctgccg tgaccgtcta tttgggtgat cagatactgg gctagttcgg 120 tcggggtggg gtgatcgaag atcgcggtgg ccggcagcgt tactgcggtg acggctgtta 180 agcggttacg tacctccacg gcactcaagg aattaaatcc cgaatcggca aacgcctggc 240 cagcgtcgaa tccggcagcg ccgtcgcgcc ccagcaccgc tgcggcatgc tcacatacca 300 cctccatcgc tgcggcgaat tgctcgtcgg ccgaccgacc ggccagccgg gcggcaaacc 360 cggaaga 367 628 518 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 628 cctcatcata tgccgataga gctctacata ttcaggagat caccatggct cgtgcggtcg 60 ggatcgactc gggaccacca actccgtcgt ctcggttctg gaangtggcg accnggtcgt 120 cgtcgccaac tccggagggc tccaggacca cccgtcaatt gtcgcgttcg cccgcaacgg 180 tgaggtgctg gtcngccagc ccgccaagaa caggcagtga ccaacgtcga tcgcaccgtg 240 cgctcggtca agcgaccatg ggcagcgact ggtccataga gattgacgca agaaatacac 300 gcccggagat ctcgccgcat tctgatgaac tgaacgcgac ccgaggctac tcggtganga 360 catnacgacg cgttatcaca ccccgcctnc ttcaatgacc ccacgtcngg caccaaggac 420 ccggcaatcg cggctcactt gngcgatngt cnacaaccaa cgcgncgcct ggctacgggc 480 tcaacaaggc anaagacaca atccgctctc gattggtg 518 629 435 DNA Mycobacterium tuberculosis 629 atactcaagc ttatcgaggc ggcgcatacc gaagcgtggg aaatccagac cgaataccgc 60 gacgtgctgg acactttggc cggcgagctg ctggaaaagg agaccctgca ccgacccgag 120 ctggaaagca tcttcgctga cgtcgaaaag cggccgcggc tcaccatgtt cgacaacttc 180 ggtggccgga tcccgtcgga caaaccgccc atcaagacac ccggcgagct cgcgatcgaa 240 cgcggcgaac cttggcccca gccggtcccc gagccggcgt tcaaggcggc gattgcgcat 300 gctacccaag ccgctgaggc cgcccggtcc gacccggcca aaccgggcac ggcgccaacg 360 gttcgcccgc cggcaccacc ggtccggtga ccgcagtacg gtccccccag cctgactacc 420 gtgccccggc gggct 435 630 398 DNA Mycobacterium tuberculosis 630 tggccgggct ggtagcccgc gtatggcaag gttccgctca atgtggttgt gatgcagcag 60 gactacgttc gcctcaatca gctcaaacgt cacccccgtg gcgtgctgcg cagcatgaag 120 gtcggcgccc gcacgatgtg ggcgaaggca acaggtaaga acctggtcgg catgggtcga 180 gccctcattg ggccgttgcg gatcgggttg cagcgcgccg gagtgccggt cgaactcaac 240 accgccttca ccgatctttt cgtcgaaaat ggcgtcgtgt ccggggtata cgtccgcgat 300 tcccacgagg cggaatccgc tgagccgcag ctgatccggg ctcgccgcgg cgtgatcctg 360 gcctgtggtg gtttcgagca taacgagcag atgcgaat 398 631 464 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 631 gtccagtcaa gcatcggtcc tctccgacta cgccaagant ggcgacgtgt cagtgcanac 60 agcgganatg gtggcgccta tgcgtcgacg ctcacaaacn gcggtgancg cgttctggtc 120 gtgcaccatc gagccgtgcc agcccggccg cgtgccgtca gccgcatcca ctggatgcct 180 tctcggngtt tcaatcangt acangcgacg ttcgccacca tcgtgccggg gcacggttag 240 cgagaaaccg ccgacttcac cgattgcctc ggtgatgccg tcgaacagat cgggcctatt 300 gtcgacagcc agtgtgatnc gtatttgccg ccgtgctcct cgtcgcaacg atgcgaacac 360 agatccgtgg nggacgatag cggctgacaa ngtgggggca acacaatcac atgccacatt 420 tcttcatttc acgcccacaa cccagacttc gtctcgatgn gccg 464 632 499 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 632 cacgcggtct ggcccgatcc gaagatccct ttgccggcgt ggcggctctg ctcggcggtg 60 ttgtacactt ctcgaacacc tcggcaccga caccaccacc gtngcttgaa caccgccaac 120 atcggcagca gatcttgatg gtcctggtga atcccacggt gactttggag tggaaggcgc 180 catactgatc gccgcgccag cacatgagct agcggcagga aaaccagcag ccgctcacct 240 tgcgcagcag cgtcnggtga tatgcctggc gcccttaatc tcgtgaacca gttggattgg 300 gtcaactggc agccttgggt ctccggtggt gccgangtgt anataagctc ccgggtccgt 360 caacgtantg cgcaggcggc ggttactcgg cgggtcaacg agccccgctc gtgagcnatc 420 agcctttgga ccgaacggga ttcatactcc gcaggcggcc ctccgaaatc ggcacatgtc 480 ctttgatcgt tcgcaacan 499 633 343 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 633 ggccatgtca catcggtggt acaggtaaac cgcgccgtgt gcgcggtctc ggagatcaga 60 acgtggtcgc agttgaaccg cgggctttca gccagtcgcg ataatcggcg gaagtcggcg 120 cctgccgccc caactagcgc gactcgccac ctagcacacc gatggcgaag gccatgtntc 180 cggccacgcc gccgcggtgc atcaccaagt catcgactag gaagctaagc gacancttgt 240 gcaggtgttc gggcagtagc tgctcggaaa atcggctgga aaccgcatca aatggtcggt 300 ccaatcgaac cggttacccg atcgtcacaa aaatctccgt cct 343 634 192 DNA Mycobacterium tuberculosis 634 gggtctacaa ccaccgggtc tgacttctgg gcttccaccg ctcgcgccgt cgcgacaaac 60 agcgcggtcg aaccgacact cgttgtgatg tcccagctat cacctccggt aggcacccaa 120 tcgaccctac ccggctatct cacccccgat ctccaggctc cgccgatcca tgcgcatccc 180 ggtccggatc cc 192 635 376 DNA Mycobacterium tuberculosis 635 caggcatgca agcttgtcgt attccgtggc actgtcagac atatgcgccg ctcctcctca 60 tcgctgcgct cggcatcgtc gccggcggtc atggcgtcac cctacccaag ccgaacgcga 120 aacgagaacg tgttccatta ttagggtgtg agcaccaata ccagattgct caccaggaac 180 tcacgcagca ccgggacgga tgtcagccac cacgcccatc tggggtggta gcggggaaat 240 acggctaacg cggctccggt gccggcagcc cagcgcagac cctcggcggc ggacacggct 300 aacaacgacg acccatagtt gttctttgcc ggatggccgt gtttgctgac atatcgggcg 360 cggcgccggc gccgcc 376 636 83 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 636 nctacgctgc tgaatgttgt gcgccggagg anctcaagac ccacgcggtt gtacgcggac 60 ntgcgacatg ttcaaccgcc gga 83 637 319 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 637 ctaaccaaca agccatggtg gttggcgccg tcgagaggtc ggcggtcgcc acaacgggaa 60 gatcgccttg agcgtcgctc gaccgccgcc tcgagttggg tcataacgaa gtactgatgc 120 cgatcatgtc gacgtgtccg tcgcatcagc gtgcagcggc gacccctcga cgagcctcgg 180 tgccgccgcg gccagggcac cagctgtttt agcgcattgt gctccgccgg taataaagga 240 ngtcggtcgc ctccgctgct gtggttgcgg aataacatct tcccttcctg caacaggatg 300 agaatggttt taattgctc 319 638 94 DNA Mycobacterium tuberculosis 638 ctaagctttc gggtccgccg ccactagtac cgcgttgccg gccccgccga cctagaatgt 60 tccgcccatt gccgtttcct cccgccgccg ggtt 94 639 122 DNA Mycobacterium tuberculosis 639 tctggtgccg ggtgtgccga cgggtccgtc cgcctctgct tcagtgattc tgtgatgcga 60 ccggcaacgt cctcgttgtt cggtgtctat gtggtccgtc tctccttgtt ccgcatacga 120 tt 122 640 210 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 640 gcgatcgntn accacaaggg cgcaaccgtt cgcgcgtcga ctgaacgtgc tgccgcctgg 60 agaactggcg ctgctgccac ctggtcggcg catcggcact tcgaggactg gatttcgacg 120 cgtggcccga cctgangtng gcggtggacn ngtgtgcacc cggttgattc ctcggccttg 180 ccgggatgcc acctgcgcct ggtggtcgat 210 641 328 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 641 cgtgaccgga cggggtgccg cgcgaaccgg tcttggccaa ttgccgggga ctggggctgg 60 agtataaagc gggcctgttg ccggaagata aagtcaaagc ggtgaccgag ctgaatcaac 120 atgcgccgct ggcgatggtc ggtgacggta ttaacgaccg ccagcgatga aagctgccgc 180 catcgggatt gcaatgggta gcggcacaga ctggcgctgg aaaccgccga cgcacattaa 240 ccataaccac ctgcgcggct ggtgcaaatg attgaactgg cacgnccact cacgccaata 300 tccgccagaa catcactatt gcgctggg 328 642 553 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 642 atactcaagc ttcttaccca nagcatgaac cccgccgtcc aatgccgcca ccgtggtgct 60 gtcggccggc cgggtgcggg cacaatcgcc gagttcggcg aacagatcct cgaaggtctt 120 cacggccagc gattgttgca cgtgtcagcc agccaagtca cggtggtttg acgccacacg 180 ttcgccaccg ccgcgccgcg cattagggca tcctaatata ggttaggcta ccctanttat 240 tcctgtggtc naaggaggca gccgaacgtg accttcccga tgtggttcgc agttccgccg 300 gaagtgccgt cagcatggct gtccaccggc atgggccccg gtccgctgct ggccgcggcc 360 agggcgtggc acgcgctggc cgcgcaatac accgaaattg caacggaact cgcaagcgtg 420 ctcgctgcgg tgcaggcaac tcgtggcagg ggcccagcgc cgacggttcg tcntccccat 480 caaccgttcc gtattggcta accacctgca cggtggcacc gcacaacgcc gccacaaacg 540 cgccccggta tac 553 643 486 DNA Mycobacterium tuberculosis 643 ggccgaactt aatcggttgt tggcggctgc cgagttgggt cactcggggg gtgtgcactg 60 gcacatggtg ggccggattc aacgcaacaa agccgggtcg ctggctcgct gggcgcacac 120 cgctcactcg gtggacagct cgcggttggt gaccgcgctg gatcgggcgg ttgttgcggc 180 gctggccgaa caccgtcgtg gcgagcggct gcgggtttac gtccaggtca gcctcgacgg 240 tgacggatcc cggggcggcg tcgacagcac gacgcccggc gccgtagacc ggatttgcgc 300 gcaggtgcag gagtcagagg gcctcgaact ggtcgggttg atgggcattc cgccgctgga 360 ttgggacccg acgaagcctt tgaccggctg caatcggagc acaaccgggt gcgtgcgatg 420 ttcccgcacg cgatcggtct gtcgcgggca tgtccaacaa cttgaaatcc cgtcaacatg 480 gtcgac 486 644 146 DNA Mycobacterium tuberculosis 644 gcttcccctg atactcgacc agccccactc gggccaatac gtgaatgtcc tagcattttt 60 cacccgttca cgggctagtc gagtagtaga cgattgatta gcctgaacgt acctccgacg 120 gccagctgac gaacgggttt gacgga 146 645 204 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 645 tcagctgtct gtagaagggc tggcgatact gtgcactgtc tgatatcgcn ncgtngtggg 60 actatncagn ccatnangat gcggttcngn nnntgcagag natcctggna cacatncggt 120 tcacgttaat cancatcgcg anttnctncg tnttcgatta nttctgctaa cgnntctnnn 180 agtgcctgcg ggtcgactct agag 204 646 209 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 646 nctctgccgg gcnagagcgc agagtcggac ggcttcgtcg atcgtgaagc gaccntgcga 60 tgancagata tcgntnacac tgctcanaaa cttcggatca tcgntgatac acaggccaac 120 gggtagcggt tgtccaaccg cttcgtcaac ganatgggat cgtgacganc ctacgctcgc 180 aggatatgtc gcngaccngn tctaganan 209 647 183 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 647 cacttcatgc tcgtgcgttg gcntcgattt gcncgagngg ttagctcctc gagtgngtga 60 cgtatcactc cggcngacta nccgtatcng cgtcccgcac cggtcaactg gtctagccac 120 accggggaga atncncgacc ggngctatcg accnatcacg gcttgtcgnn aagatagnca 180 gcc 183 648 154 DNA Mycobacterium tuberculosis 648 atactcaagc ttgccaaccg ccaccctgca tccggggggc gagcactgct ccgccgacca 60 gtacgaacca acctgcggtg cccaggccat tgacaatgtg ctggtcggcg cccgcgagtt 120 ctagcacagc aacgccgcgg ccaccacagg ggcg 154 649 219 DNA Mycobacterium tuberculosis 649 cggtcggtgt gcttggcggc gtcggtatca acaccgccca cgaaatgggg cacaagaagg 60 attcgctgga gcggtggctg tccaagatca ccctcgccca gacctgctac gggcacttct 120 acatcgagca caaccgtggc catcacgtcc gggtgtccac accggaagac ccggcgtcgg 180 cgcggttcgg caaaactttg tgggatttcc cgccccccc 219 650 307 DNA Mycobacterium tuberculosis 650 aatactcaag cttcgcggag gtggtggggc aggagcacgt caccgcgccg ctgtcggtgg 60 cgctggatgc cggccggatc aaccacgcgt acctgttctc tgggccgcgt ggctgcggaa 120 agacgtcgtc agcgcgtatc ctggcgcggt cgttgaactg tgcgcagggc cctaccgcca 180 acccgtgcgg ggtctgcgaa tcctgcgttt cgttggcgcc caacgccccc ggcagcatcg 240 acgtggtaga gctggatgcc gccagccacg gcggcgtgga gcaaccccgc gagctgcggg 300 accgccc 307 651 252 DNA Mycobacterium tuberculosis 651 gatggcactc acgctggaca agaccttcac aaaatctgaa atcctgaccc gatacttgaa 60 cctggtctcg ttcggcaata actcgttcgg cgtgcaggac gcggcgcaaa cgtacttcgg 120 catcaacgcg tccgacctga aattggcagc aaaccggcgc tgctgggccg ggcatggtgc 180 aatccgaaca agcacgctca acccgtacac caaccccgaa gggccgctgg cccggcggaa 240 ccttgtcctc ca 252 652 402 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 652 aacagctatg accatgatta cgccaagcta tttaggtgac actatagaat actcaagctt 60 ctgggcgtcg tggtgcccgg cctgccggtg caggaactgg attttactgc catctctcgc 120 gaccctgagg tggtccaggc ttacaacacc gacccactcg tgcaccacgg acgggttccg 180 gccgggattg gccgcgcgct gctgcangtg ggcgagacca tgccgcggcg ancaccggca 240 ttgaccgcgc cgctgctagt gctgcacggc accgatgacc ggctgatccc catcgaaggc 300 agccgtcgcc tggtcnaatg tntnggatcn gccgacgtgc anctgaanga ntatccccgg 360 ctgtnccacn aggtgttcaa cgaaccggan cgcaaccaag tg 402 653 429 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 653 caaggcatac gccaagaccc aagggatcgc agtcacctcc gtcaacggcc tggtcgccgg 60 ccacgggtcc gtgcaggaga cgtggctggc catgcaaagc gccgccgcct tatcaggaac 120 gccccggctt gtcggctttt cctgcatcga cacatttccg gaggtgttgt ggttggcgca 180 ncgcgcgaga caggcctggg atggcgtgcg catcgtcatc gggaatgcga tggcaacact 240 gaactacgag cgcatcctgc gccagcatga ctgtttcgac tacgtcgtcg ttggcgacgg 300 ggangtagcg ttcaccaagc tggccttggc cctggcgaat gacctgcggt tgacgactcc 360 cgggactaac ccgccgtant gagcaaggac agattctgcg cacaccctcc tcgctggtcg 420 accttgaca 429 654 353 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 654 aacagctatg accatgatta cgccaagcta tttaggtgac actatagaat actcaagctt 60 gccggtgatc tgggtggcca actcggcggg caccatctcc atcacgacng caaacgctcc 120 ggcttcggcg acagcgatcg cgtctgcgat ngtttgttcg gcggcgtctc cgcggccctg 180 cacccggaag ccgcccaagg tgttgacnct ttgcggggtg aagccgatgt gtgccatcac 240 cgggatnccc gccgcggtca gacangcgat ttgctcggcc acccgctcac cgccctcgan 300 cttgacngca tgtgcgccgc cgtccttgaa gaaaccggtg gcggnggcaa ccc 353 655 464 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 655 cgttgagatc cagctgcgca ctgtgcagcg cctcggtggt ctgctcggcc tgccgggata 60 actcgttgag cttggccagc gcgtcgtcgg ccggatcagc cagcacattc gcggccagga 120 cgccggagga gacggtgaag ctcgcaaaga aacctatggc ggaccgcatg attacacgcg 180 cgatcaacca cctctggtcg agcctcaaaa tttgcttcct taaacgggcc atcgacggat 240 gacgtcgagc tggtttaggt ctcaaacagg ttacgaaacg atctcggaat tgtccaaaag 300 gggaagttaa gaaaatggat agatttctac catttcgctg tggacgatcg tacttctgct 360 atagggctcc aggggcatcg acacgcaacg accttacgcg acaccggatc cgcgctggcg 420 gcggaacggc accangcgca accgaagggc caatccgaca tcgg 464 656 515 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 656 atactcaagc ttatctaggc gccagcttga ttggtctggt tgcattggcc agctgcgcga 60 gcctggctca cttcaactac aacaaccgca aacaattgcc gccttcggat ccgagttcgg 120 ttgggtacgc ggcaatggan caccatttct cggtgaatca gactattcct gagtacttga 180 tcatccactc tgcacacgac ctgcgaaccc cgcgcggcct tgccgacctg gagcagctgg 240 cgcaacgtgt gagccanatc ccaggcgttg ccatggttcg cggtgtgacc cggccaaacg 300 gggaaaccct tgaacaggcc cgggcgacat accaagccgg ccaagttggc aaccggctgg 360 gcggcgcgtc gcgaatgatc gatgagcgca ccggcgacct gaatcggctg gcatcgggtg 420 ccaacctgtt ggccgacaat ctcggtgact tcgcggtcaa gtcagccggg ccgttgcggg 480 tgtccgcagc cttgtccagc ccctcgctta ctcca 515 657 403 DNA Mycobacterium tuberculosis 657 caggcatgca agctttttga gcgtcgcgcg gggcagcttc gccggcaatt ctactagcga 60 gaagtctggc ccgatacgga tctgaccgaa gtcgctgcgg tgcagcccac cctcattggc 120 gatggcgccg acgatggcgc ctggaccgat cttgtgccgc ttgccgacgg cgacgcggta 180 ggtggtcaag tccggtctac gcttgggcct ttgcggacgg tcccgacgct ggtcgcggtt 240 gcgccgcgaa agcggcgggt cgggtgccat caggaatgcc tcaccgccgc ggcactgcac 300 ggccagtgcc cgcggcgatt cagccatcgg gacatcatgc tcgcttcata ctcctcgacc 360 agtcggcgga acagctcgat tcccggaacg cccacgcatg gtg 403 658 444 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 658 aacagctatg accatgatta cgccaagcta tttaggtgac actatagaat actcaagctt 60 gtagaaaaag atcggtgagc gcatcgattc gctccgccgg gtttgccgct gcggcggcgg 120 agctgccgtg accgtctatt tgggtgatca gatactgggc tagttcggtc ggggtggggt 180 gatcgaagat cgcggtggcc ggcagcgtta ctgcggtgac agctgttaag cggttacgta 240 tctccacggc actcaaggaa ttaaatcccg aatcggcaaa cgcctggcca gcgtcnagtc 300 cggcagcgcc gtcncgcccc agcaccgctg cggcatgctc acataccacc tcgatcgctg 360 cggcganttg ctcgtcngcc gaccgaccgg ccanccgggc ggcaaacccn gaagacccaa 420 gaattcatca ccaccatcgc tagc 444 659 437 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 659 ccttcttgac acccacctcg ccatcgacct tgagcactcc gtcgtagttg gtgaacatgt 60 gaccggcgat cgggcgggtg aacgcgtact gggtgtcggt gtcgacgttc atcttcacca 120 cgccgtagcg cagcgcctcc tcgatctccg acttaagcga acccgagccg ccgtggaaca 180 cgaaatcnaa cggcttggcg tcngccggca gtccgagctt ggccgccgcc acctgttgcc 240 cttgcgcaag gatgtcnggg cgaancttga cgttgccggg cttgtanacg ccatgcacgt 300 tgccgaacgt cncggccagc angtatttgc cgtgctcacc ggcgcccanc gcctcgatgg 360 ttttctcgaa gtcctccggg ctggtgtaca gcttctcgtt gatctcgttc gccacgccgt 420 cctcttcgcc gccgacg 437 660 422 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 660 aacagctatg accatgatta cgccaagcta tttaggtgac actatagaat actcaagctt 60 ggaaaggaga tccccgggaa cctggtggca accccgccat tggggttgtt gggattgccg 120 atcagcgtga angaaagctc gtctggagac agcgggtcgg ccgaagccgc aagattggcc 180 atcactagtg acganatcgt ggcgctctgc gagtanccna agacagtgac gttgttnccg 240 gcggcaattt gctgccgaat cgcactttcg agaatgacng caccctgcgc caccgangaa 300 tcnaaagtga ggttcttgat cacgaccacc gggtngagcc cttggggcgt gaagancgcc 360 tgcgcnataa cacccgggac gctgccactc atgtncagcg cgttcgcgan ctcnacatat 420 ct 422 661 412 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 661 tcctggtgat cganggccgc ggttccggcc gaaaatccgg ttcgggttcg ggtcgcggtt 60 ccaacttgan cgcggtccgc agctgattca ccgtggcaac gccggccaac tgcgcataat 120 gcgcatccga accctcaccc gcccgccccg cgatcacccc aacctgatcc aacgacaacc 180 gcccctcccg cataccccgg gcgcagcgcg gaaactccgg caaccgccgc gccaccgtgg 240 cgatcgtgtg ggcgttgcct gacgaacanc ccatcttcca ggccaccaac cccgccaccg 300 accgcgcccc cgtcacaccc cacaacccgt cgcgatccag ctcagccacg atctccacaa 360 tgcgcccatc aatcgcattg cgctgaacgg gcaactccgc caactcctcc aa 412 662 467 DNA Mycobacterium tuberculosis 662 aacagctatg accatgatta cgccaagcta tttaggtgac actatagaat actcaagatc 60 tggtacccat ccgtgataca ttgaggctgt tccctggggg tcgttacctt ccacgagcaa 120 aacacgtagc cccttcagag ccagatcctg agcaagatga acagaaactg aggttttgta 180 aacgccacct ttatgggcag caaccccgat caccggtgga aatacgtctt cagcacgtcg 240 caatcgcgta ccaaacacat cacgcatatg attaatttgt tcaattgtat aaccaacacg 300 ttgctcaacc cgtcctcgaa tttccatatc cgggtgcggt agtcgccctg ctttctcggc 360 atctctgata gcctgagaag aaaccccaac taaatccgct gcttcaccta ttctccagcg 420 ccgggttatt ttcctcgctt ccgggctgtc atcattaaac tgtgcaa 467 663 452 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 663 aacagctatg accatgatta cgccaagcta tttaggtgac actatagaat actcaagctt 60 ancgccacct cccgggcgga actccacggc gtggatnaag gtaccggccg ggatgttgcg 120 caatggcagg ttgttgcccg gcttgangtc cgcgttagcg ccggattcca ccacatcccc 180 ttgcgaaant ccgttgggtn cnatgatgtn ncgcttctcc ccntcnanat aatggancaa 240 cgcnatccgt gcggtacggt tcgggtcnta ctccatgtnc gcgaccttgg cgttganacc 300 atctttgtca ttgcggcgaa agtcnatcat ccggtnagcn cgcntatgan cgccgccttt 360 gtgccgggtg gtaatccggc catgcgcntt gcgtccaccg cgaacgtgca acgggggcnc 420 caacganttc tccngggttg aaccggtnat ct 452 664 93 DNA Mycobacterium tuberculosis 664 tgtgtgtggt ggtaacccat ctgagcagtg tgccaaaccg gggcagccag ctcccaattg 60 acgtgagccc gctcacttgc tgggtaagcg tcg 93 665 352 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 665 aacagctatg accatgatta cgccaagcta tttaggtgac actatanaat actcaagctt 60 gcgggtnatn gccttggtca acggcaccgt gatcggatcn gggtctaccg cacacatnga 120 ctggagcttc ggcgaantca tcgcctatgc ctcgcggggg gtgacgctga ncccnggtga 180 cntgttcngc tcnggcacgg tgcccacctg cacgctcntc naacacctca ngccaccgga 240 atcattcccn ggctggctgc acganagcga nnttgtcncc ctccaagtct aaaggctggg 300 cgananaagc anaacgtccc gacnaacggc actccttttc cntttgctct tc 352 666 448 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 666 gaaatcattg atggtttgag tcaccaggcc gatcaagcct tcgccgagcc aaattccaat 60 caagaggccc aagcccgtac caatcagccc ggcaacgagg gattccgtca ttatcagcca 120 aaataactgc tctcgggtta cacccaaaca gcgcaatatg gcgaaaaacg gtcgccgttg 180 cacgacatta aatgtcacgg tattgtagat taaaaagata cccaccaaca angcaatcaa 240 actgagagcg gttaaattga ccgtaaaagc gtccgtcatc tgtttgacng tgtcccgttg 300 ggtatccgac gtttccatac gcacaccggc cggcagtctt tgttggatgc gtnttgcaat 360 ggcctcatct ttgatgatca aatcgatgtn gctcagtctt ccgggcatat ggaacaactc 420 ttgggccgtg gaaatatcag caatgata 448 667 386 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 667 ctttcgccca ggccggcgcg gatgtcctca tcgcttcacg aacatcatcc gagcttgacg 60 ctgtcgccga acagatccgc gctgccggcc gccgcgccca caccgttgcc gccgatctgg 120 cccatcccga ggtgaccgcg cagctggctg gtcaggccgt cggagctttc gggaagctcg 180 acatcgtcgt caacaacgtt ggcggcacca tgcccaacac gctgctaagc acctcgacca 240 angacctcgc ggacgccttc gccttcaacg tgggcaccgc ccacgcgctg accgtcgcgg 300 cggtgccgtt gatgctggaa cactccggcg gcggcagcgt gatcaacatc agctccacca 360 tgggccggct ggcggcgcgg ggtttc 386 668 378 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 668 tgtgggctcc gatccggcgc gcatggcatc gacggcgacg ccgatcgatg acggccaggc 60 ttacgagctt gagggtgtga agttgtggac caccaacggt gtggtagcgg acctgctagt 120 ggttatggcg cgggtaccgc gcagtgaagg gcnccgaggg ggaatcancg cctttgtcgt 180 cgaggctgat tcgcccggga tcaccgtgga gcggcgcaac aagttcatgg gactgcgtgg 240 catcgaaaac ggcgtgaccc ggcttcntcg cgtcagggtg cccaaagaca acttgatcgc 300 anggaagcga cggtctgaag atcgcgctga ccacactcaa cgccggacgg ctgtccctac 360 cggcgatcca accggagt 378 669 344 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 669 gagctggccg agctggaccg gttcaccgcg gaactaccgt tctcgctcga cgactttcag 60 cagcgggctt gcagcgcgct ggaacgcggc cacggtgtgc tggtgtgcgc gccgaccggc 120 gctggcaaga cagtggtcgg cgagttcgcc gtgcacctgg cgctggcggc cggcagtaaa 180 tgtttctaca ccacgccgct gaaagccctg agcaaccaaa agcacaccga tctcacagca 240 cgctacggcc gtgaccagat ctggctgctg accggtgacc tgtcngtcaa cggcaaccgc 300 cggtggtggt gatgaccacc gaaatgctgc gcaacatgct ctac 344 670 411 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 670 gatctctgga tcggcggggc tctccgggcc ggcctcggcg acctcagcgg gccgcgcctt 60 ccggccgaac cattccctag ccatagatga ccgcacctcg atgcacggtt tggcggcaac 120 gcggcaaggc gtcngtcggg cccagccgcg gcaatgcggg tacccgggag cgcgggtcng 180 tanaccancg ctggactgcg tcgcgcggtg cgtcnacntc aaagtccccg gcgtcccata 240 tcgcgtatga cgcgggcgcg cccggcacca ngggtgccga tccggccgtc tcgaacacca 300 ccggcccgcc agccgccgcg ggtccggcag cnaacccgcc cgcgccgata cccgctgccc 360 gcgtgcgtga ttgaccgccg cgcgcacgct ggccanggat caaagcccgt g 411 671 473 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 671 ggacgcgtag cccgccaggc cggtcagggt gcccttccag tccacgccgc tgtggtcggc 60 gaaccgctta tcttcaatcg agacgatcgc cagcttcatc gtgttggcga tcttgtccga 120 gggcacctcg aaccggcgct gcgagtncag ccacgcgatc gtgttgccct tcgcgtcgac 180 catcgtcgat accgcaggca cttgcccctc gagcagctgg gccgagccgt tggcaacgac 240 ctcagangca cgattggaca tcagccctag cccgcctgcg aacgggaacg tcagcgcagt 300 ggcgacgaca ctggccaaca gacagcaccc agccagcttc agaacggtga tcgcggccgg 360 gaagcgctcg ggcatgcgtn ctacagtagc gacctcctgt cactccacgt gccgctcggt 420 ccaatagaat ctttccgcgg gcgggtgaat ctctgcngga tcggggcngg cgc 473 672 357 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 672 gctcgttgcc ggcggcgatc tcgtcgagct cgtcttccat cgccgcggtg aagtcgtagt 60 cgacgagccg accgaaatgc tgctcgagca gaccggttac cgcgaacgcc acccatgacg 120 gcaccagtgc actgcccttc ttgtgcacgt ngccgcgatc ctggatggtc ttgatgatcg 180 acgantaggt cgacgggcgg ccgatgccca gctcctcgag cgctttgacc agcgacgcct 240 cngtgtnncg ggccggcggg ttggtggcat ggccgtctgg ggtcaactcg acnatgtcca 300 accgttgacc cggggtcaga tggggcagtc gccgctcggc atcgtcagcc tcgccgc 357 673 402 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 673 gtctttcgat ggctgcttct tcggcgctga cgctggcgat ctatcacccc cagcagttcg 60 tctacgcggg agcgatgtcg ggcctgttgg acccctccca ggcgatgggt cccaccctga 120 tcggcctggc gatgggtgac gctggcggct acaaggcctc cgacatgtgg ggcccgaagg 180 aggacccggc gtggcagcgc aacgacccgc tgttgaacgt cnggaanctg atcgccaacn 240 acacccncgt ctgggtgtac tgcggcaacn gcaagccgtc ggatctgggt ggcaacaacc 300 tgccggccaa gttcctcgag ggcttcgtgc ggaccatcaa catcaagttc caagacgcct 360 acaacgccng tggcggccac aaccgcgtgt tcgacttccc gg 402 674 336 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 674 gccaggtcga ggtcccatgc gcgtgggcca ttgatgctga tcgccaggac gtcaaanatt 60 tggtccggcg tcagctgggc gaaaaacgtg ggccccagga cttgcccgga gctgcccggg 120 ttcccgtcgc gcagctcggc ggccccggtc agaaanaaat tgcgccaggt cgcacactcc 180 gcgccgtang ccagctgctc cagggtgtcg gcatagagcc cgcgggccgc agcgtgctcg 240 ctgtcggcga acaccgcatg gtcgagaagc gttgccgccc aacggaaatc acctgcgtcn 300 aangcttcgc gggccaactc cagcactcgg tcgatg 336 675 405 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 675 naaacgttcc ggcttnggtg ccgggcgctt atttgcgtct ctgggatcac nctcagtcgc 60 cggcggctgc cgttgggcta tnanttgcac cganccggaa aatccgcacn anaactgcna 120 gtagcggcct gcagaantgc atcctcggcg aancngacta ccggtggaca ncnacaagcg 180 ccgccgaaca acgcactggc ccgagggatn ggcgtctatc ggccccgccc gtcgaactng 240 gaacagacng tgcggttcta ccgtgatctg gtgggaatgc tcnaccanac cttcccnann 300 gctacggaac nacggcgcga tattcngccn tcccanctcg agcctgacnc tngatatcgt 360 cgannctcac catcncgatc ngctgtgccg gtnttgctcg gactn 405 676 389 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 676 cgaacgacga acnccncaag ccatggtggt tggcgccgtc aaaaggtccg cggtcgccac 60 tactggaaaa tcgccttgag cgtcnctcga ccnccgcctc gagttgggtc ntaacgaaat 120 acctgatgcc gatcangtcn acgtctccgt cgcnncaacg tgcagcggcg acccactcta 180 cnangtctcg gtnccgccnc ggccagngca ccaccagtga cnaatccntg cgccntcggg 240 ccnagcantc ccggtgcnac cgnggtgggt ccggcgatgg tngggtgtnc tcnntacngg 300 aacgccagcg cnatcancat cggcanactc ncgtcgatgt gccgcggcgc aaccatcccc 360 cacaatgatc nggtgcgtct gatcaggcn 389 677 135 DNA Mycobacterium tuberculosis 677 ttaggcgtga cggccaccgg ggccactccg cacaatctgt acccgaccaa gatctacacc 60 atcgaatacg acggcgtcgc cgactttccg cggtacccgc tcaactttgt gtcgaccctc 120 aacgccattg ccggc 135 678 140 DNA Mycobacterium tuberculosis 678 cgtcaccccg atgcgcccag atcggggctt cgcagataaa gcacgaactg gcgggcaaaa 60 cgtcgatctc ggagccggaa gggcaatcag ccgaccgtcg acgaacgaca ccggcgagac 120 cacttaggca gtgacggcct 140 679 272 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 679 cttttcncga tgtctcatga tnccnangga gaacnntgcn ancncngccg ctgacntngc 60 ncaccgctnt ggcngnggtg acattggtgg tggttgcggg ctgcnacgcc cgactcgang 120 ccganccatn tnttgcggcc gaccgcntnt cgtctcnacc gcanncccna tctcngccgc 180 ncccggtgga nctacngctn cttcgccatc tctcgccnat ggctccngcg nntcgcncaa 240 cgtntggttt ggtnanctgc ctacctggtc nt 272 680 507 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 680 gctgcgccag tcgttcggtg cggtcatgcc gttggaccna ccatcggagt tagttgccga 60 accgcggacc accgcaagca cccggtcctg gtcgcgcacc gcgtcggcca accgcttgag 120 caccaccacg ccgcagccct cgccgcgcac gaatccatcc gcgttggcgt cnaanctgtn 180 gcatcggtcg gtcggtgaca gcgccgacca cttggacagc gcgatggcgg tgaacggtna 240 ntaggtgacc tgccnccncg cccgccaatg cccacctccg cttcacncat gcgaatggtc 300 tgacacgccn agtgaattgc caccagcgac aacaaaaatc ggtatctncn gcgacggcgg 360 acacgcnatc ccnactgata ctcgatccgc cccaccgctt gnanctccgg gttccngtgc 420 tcatgtaccn tcatgtcggt ctgcgcncga tattgacgat cgtgtttccc acgannanag 480 ancctcatca cgccggttcg agtgccg 507 681 470 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 681 ctgtgtgcgg ncggcgcgat atcggccttt ttactaaccg aacccgatgt gggctccgat 60 ccggcgcgca tggcatctac ngcgacgccg atcgatgacg gccaggctta cgagcttgag 120 ggtgtgaant tgtggaccnc caacggtgtg gtagcggacc tgctantggt tatggcgcgg 180 gtaccgcgca gtgaanggca ccgaggggga atcancgcct ttgtcgtcta ngctgattct 240 cccgggatca ccntggagcg cnccncnant tcatgggact gcgtggcatc caanacggcg 300 tgaccggctt catccntcng ggtgcccaaa gacaacttga tcngcnngga agcgacgtct 360 gaanatcgcg ctgatcncac tcaacgccgg acgctgtcct accggcgatc gcaccggant 420 tgccaanccg cgctnannat ncgcgngaat gnccgtccac nantgcatgg 470 682 346 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 682 tggggtgccg ggcgccgagt tgcgtccctg ggatcacgca gagtcgccgg cggctgccgt 60 tgggctatga attgcaccga gccggaaaat ccgcancaaa actgcgagta gcggcctgca 120 gaagtgcanc ctcggcgaaa cggagtacgg tggacaacga aaagcgccgc cgaacnacgc 180 actggcccga gggattggcg tcaatcggcc ccgcccgtcg aacttggaag anacantgcg 240 gttctaccgt gatctggtgg gaatgctcca acnnaccttc nccgaaagct acggaagcna 300 cggcgcgatn ttcggccttc ccagctcgac ctgacgctgg aaatcg 346 683 453 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 683 nggcngggaa gttaatgccc tactggttcn atgctcncac ntcnccngtg acnncctgcn 60 ccgacccgcc gaggtcctgn ccgtnaccac cgancnggcg atccgggact ctngtacgca 120 tccaacanng ancaacgtgc acgggcggag tngtnccgcc acttcgncna tgacggggtc 180 gatccnttcg acgtccgtcg ccgcgtcggt cgagtggcgg tcacnctccn ngtactcgac 240 cncacngacg agaggactcg ancccatcta cgtgtggacg aaacanatct tctgtccnac 300 gactacacca ccacccaggc catcgccgnc gcccgcgang ccccttcgac gccntactgg 360 tccngnggng gcgctctccg gttgtctnnc ncntgncgtg ttccttcacn cactgcccna 420 catcganccc gagcnatncn angtccgtca atc 453 684 382 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 684 ggacactgtt cgcgtgcccc tcgtcaaagc cggagtggtc gtgctgcgcc ggacccgacc 60 cgaccttcag cgggggttca cagctccgtg ggtgccgtta cttccgatcg ccgcagtgtg 120 cgcgtgcctg tggctgatgc tgaacctcac cgcgttgact tggatccggt tcgggatctg 180 gctggtggcc ggaaccgcga tttatgtcng ctacgggcgc cggcactcgg cgcatggcct 240 tcggcaagcn cnananaacg cgacccggag gtgttgaact agcttcgccg cgtatttaca 300 aattgcntta tatgtctaca cataagacgc aaactgctct attgtcaant cccancgtgg 360 tgtggcncat gaagatgttt gg 382 685 408 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 685 tccttctcgg tatcggtttg ggctgtcacc ancagttggt agttcttcac gtnctgttgt 60 tcgagcgtcn agccgtcgcg cgtgtcnang tcnccggacg cgtatcccgc caggccggtc 120 anggtgccct tccantccac gccgctgtgg tcggcgaacg ctnatcttca atcgagacca 180 tcgccagctt catcntgttg gcgatcttgt cnnacggcac ctcnaaccgg cgctnctagt 240 acnccacncn atcntgttnc cttcncgtcn acatcctcga tnccncntgc actttccctc 300 gancncctgg gccgagccgt tggcantnac ctcngagccc cattggacat cancccancc 360 cgcctgcgaa cgggaacgtc agcncnctgg cgacaacctg gccaacan 408 686 372 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 686 cacnccgtga tcgcnagccc cngtagaaat ngttgagcca gttggtgcgg cgctcgttgc 60 cggcggtnat ctcgtcgagc tcntcttcca tcgccgcggt gaagtcgtac tcgacnagcc 120 gaccnaaatg ctgctcnagc agaccggtta ccnnnaacnc cncctcntga cngcaccagt 180 gcnctgccct tcttgtgcac gtacccgcna tcctggatgg tcttgatgat cnactantnt 240 gtcgacgggc ggccgatgcc catctcctcn agcgctttga ccagcgacnc ctcggtgtat 300 cgggccggcg ggttngtggc atggccgtct ggggtcanct cnacnatntt canccgttga 360 cccggggtca ca 372 687 403 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 687 tggccttctt gncangggcn nacatnngct atngcgagcg tgtaaccgat catcntccng 60 gcgactgtgg cctgancggc aagggtngcc tnattcntcc tcctgnggca tggttnccac 120 acggaatgnc ggtaagtctg gtcggcaacc tggcccgctg cgggttgggt tcggattcgc 180 tcggctanta aggtgctcgc ctggtgtnac nactaatcnc natatacnct tancgggagt 240 ngncgtcccg atcctngccc tgccgcnggc gatcncgttc gcancaccgc caccggaact 300 cncaangtgc gctcatcggg ctctacgcgc catcttcccc ggattcttcg cggcngngtn 360 ccgngggacc ccggactgtg acnggcccaa cggctcatca tcg 403 688 356 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 688 ccggatagcg gtgtctgaac ttcgcccgtt ccctccancg cattgagctt cagcccgacc 60 ggcaggtnng gagtcggcat gcggtccttc gccccgaccc cgctggctaa atanccaccc 120 ccgagcgcgg tcacggtctt tgcaccggga cgacgcatac cggcagcgcg aacatcnccg 180 cgggctgcag cntgaacgtc caataccant cnaacagtgt ccgcgcgtna aaacccganc 240 cggcggtcgc ttcngtaatc aacggctcct gcgcaaccag ctgcaagtcg ccggtgccac 300 cggcgttgac gatcttgatg tctgcganct cgcgcaccag ctcgacggcc cgggca 356 689 439 DNA Mycobacterium tuberculosis 689 cctcccgacc acatacaggc aaagtaatgg cattaccgcg agccattact cctacgcgcg 60 caattaacga atccaccatc ggggcagctg gtgtcgataa cgaagtatct tcaaccggtt 120 gagtattgag cgtatgtttt ggaataacag gcgcacgctt cattatctaa tctcccagcg 180 tggtttaatc agacgatcga aaatttcatt gcagacaggt tcccaaatag aaagagcatt 240 tctccaggca ccagttgaag agcgttgatc aatggcctgt tcaaaaacag ttctcatccg 300 gatctgacct ttaccaactt catccgtttc acgtacaaca ttttttagaa ccatgcttcc 360 ccaggcatcc cgaatttgct cctccatcca cggggactga gagccattac tattgctgta 420 tttggtaagc aaaatacgt 439 690 442 DNA Mycobacterium tuberculosis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 690 cttcacntcc gtacggctcg ggtacgcttc ggtcncattg tgcgagtgat agatgacgac 60 cgggacctcg tcggcatctt ccatagcccg ccacaccttc agttgctcac cggaatccaa 120 ccggtanaag gtcggcganc gctcngcatt ggtcatcggg atatgccgct cgggacggtc 180 anagccctcg ggtccggcca gcactccgca ggcttcgtcg gggtggtcgc gacgcgcatg 240 ggccaccatc gcattcacca ggtctgcgcg aatcaccagc acgtanacgg ttcctttcct 300 aagcaacacc gaantttcag gacccgaatg ctccgggaaa catgtcacgg taggtcggta 360 ttccggctac cggctganca ttgagcacgc cggccagcac cgcacgaacc aggcaatcag 420 ccgccgccgc acccgaccgc gg 442 691 365 DNA Mycobacterium tuberculosis 691 caggcatgca agcttgatgc cgccgaaacc gagcgtgagc acgccgccag ccaccacgcg 60 cgggtcgggc gccgggcccg ggccgccagg ctgctccgct cggtgatggc acgccaccgc 120 gacaccaccc ggctgcgcta cgtcgagcca taccgggcgg agctacatcg gctcggccgc 180 ccagtgttcg ggccctcttt cgaggtcgag gtcgataccg atttgcgcat ccgcagccgc 240 accctggacg acagaaccgt gccctacgaa ttgcttgtcg ggcggggcca aagaacagct 300 tggcatcctg gcgcgattgg ccggcgcggc gctggtcgcc aaggaagacc cgttccggtg 360 ctgat 365 692 307 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 692 aagntcgggt ttccacacgc gcggtttgac cctagtcata tgtaatcatg tgtaccatgt 60 gcgggcgctt ttcgacggcc gcgaaccacc gganatttcc tgtgatttca ctgcatgcgt 120 accatctggc acaattgagc anttgtctnt cgcggtggtc ggncgggttg cgtgccgcct 180 gctgcganat gcaccantaa gcccgaaccc accggcttgg tgaccaccgc acgctgcgtg 240 tggggggtaa ccactccgcg accccaagga tggtcatttc caatgaaccg gctggacttc 300 gtccana 307 693 414 DNA Mycobacterium bovis 693 gtcgcggttc gatcgacccg atcttcacct cgtaacctcg atgcttagca ggatccagct 60 tgaccgcgtt tggctctacc cactctttga gtggcgccgt cgcctgtgcc ccatcggtgt 120 tcatgacgaa cgcttcgaaa gacttcctct tgtgagccgg aatgtctgcg taaagaagtt 180 ccatgtccgg gaagtagacc cggtcgccct ccacgtggta ctccttcgag gtccgcttct 240 cgccggatcc gataaacacc ggccccaggc accgcagcgt gagttcgaac ggcttcaggt 300 aggtgttcat gcggcggact ccgggagtgc gagaaatagc ggtcgcgcgt agctgtagac 360 cggatggttt ccgcccaggc tgacgtcgaa gatgcctcct tggaaggggc gcga 414 694 256 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 694 aactcaagtt tttacggtga tcgcgcatca cctggttcat gaactggaag cagcgcagcg 60 cttccttttc ggccgcaaca tgagccagcc tctcgtcggc ggtcgggtgc aggtgctcgg 120 gcagctcggc cgcgacagcc gcctgaccct gaaaccagct tccatatccc gcgacnaacg 180 acgccagtcc gctacgtaac ccctccgcga ctgtccatgg acaacagcgc gttctccacc 240 gaccgggccc gggtgt 256 695 328 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 695 gtgcaggttt cgacaatgtg gtgccggttc ggcggctacg tgccatcgag acactggcgc 60 angctatcgc acccgttatc ggctgcgagc aaatcgcggt atgcgttctt gagcatgagt 120 cggcgaccgt cgtcatggtc gacacccacg acggaaagac gcagatcgcc gtcaagcatg 180 tgtgccgcgg attatcagga ctgacctcct ggctgaccgg catgtttggt cgcgatgcct 240 ggcgcccggc cggcgtggtc gtggtcggct cggatagcga ggtcagcgaa ttctcgtggc 300 agctcgaaag ggtcctgccg gtgccggt 328 696 278 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 696 ttcgagtcat gcgcccgcct cgaccacgaa natgcacgtc gnggttcgat cgacccgatc 60 ttcacctcgt aacctcgatg cttagcagga tccagcttga ccgcgtttgg ctctacccac 120 tctttgagtg gcgccgtcgc ctgtgcccca tcggtgttca tgacgaacgc ttcgaaagac 180 ttcctcttgt gagccggaat gtctgcgtaa agaagttcca tgtccgggaa gtagacccgg 240 tcgccctcca cgtggtactc cttcgaggtc cgcttctc 278 697 264 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 697 gtcatgtgta ccatttgcgg gcgcttttcg acggccgcga aacaccggag atttcctgtg 60 atttcactgc atgcgtaccg tctggcacaa ttgagcagtt gtctgtcgcg gtggtcggcc 120 gggttgcgtg ccgcctgctg cgagatgcac caataagccc gaacccaccg gcttggtgac 180 caccgcacgc tgcgtgtggg gggtaaccac gccgcgaccc caaggatggt catttccaat 240 gaaccggctg gacttcntca acaa 264 698 169 DNA Mycobacterium bovis 698 aacagcgcgg ttgaactgat aggtgcggcc cggctcgagc aggccgggcc atttgttcga 60 tgcggttacc gaaagatctc ttcggtgacc tgcccgccgc cggccagctc ggcccagtgc 120 ccggcgttgg ccgccgcggc gacgatcttg gcgtccacgg tggtcgggg 169 699 256 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 699 gcatctgggc tggcggtggt tcgccgctcc gaagccgtcg aacaccatcg ccagcgcggc 60 ttccacatca acgaccattt cggccagctt gcggcgcatc agcggcttgt cgatgagcgc 120 cccaccgaat gcccgccgct gcccggcgta ncacagcgat tcgaccagcg cgcggcgcgc 180 gttgccgagg gcgaacgaag cggtgcccaa ccgcaatctg ttggtcagct ccatcatgcg 240 ggtgagtccc ttgccg 256 700 291 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 700 atcggtttcc agcaacagcc gatcgacggc ttcgcccagg ccgctcccgg gcgacccgac 60 cattgctgtc gccgcgtaac gccatcacgg atgacgcgca gttcgtcgct gtctagctcc 120 accatcgcct gcacaccggc ggccagnacc cattggccgt cgcactcgta nagcaggtaa 180 tcctcgtcga cggactcggt aaccaccgcc gccagctccg ctgccaggtc ggcggggttg 240 acaccggcgg gcatcgggat ggacgacgac gcggtgctga cggcgcctgt c 291 701 315 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 701 agcggtttcc cangcgggat gtgctgtgag cgccgcacca ccagcgccga cgctaaggat 60 ggaacgcacg gcatcttctg acgcgtaacc gcgttgtgat cgcgagctga ggagacggta 120 tgggggaggg ttctcggagg ccatctggga tgttgatgtc tgtcgatctt gagccggtgc 180 aactcgtcgg cccggacggt acgccgacgg ccgaacgccg ctaccaccgt gaccttcctg 240 aggaaacgct gcgttggctc tacgagatga tggtggtcac ccgcgagctg gataccgaat 300 tcgtcaatct gcacg 315 702 328 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 702 caagcttcca caggtaggga tcgaggaaca gcgcgttgaa ctgataggtg cggcccggct 60 cgagcaggcc ggccatttgt tcgatgcggt taccgaaaat ctcttcggtg acctgcccgc 120 cgccggccag ctcggcccag tgcccggcgt tggccgccgc ggcaacgatc ttggcgtcca 180 cggtggtcgg ggtcatgccc gcgagcagga tcggcgagcg gccggtcagc cgggtgaact 240 tcgtcgaaag cttgaccctg ccgtcgggga ggcgaaccac ggtcggtgcg tanctccacc 300 aagcccgggc aacctcgggg gtggcgcc 328 703 352 DNA Mycobacterium bovis 703 tggacctcat gacaacgcgg cggcgattac ccccgctacc gccagcagca tgacggcggt 60 agcgaacacc gccggatgca gcgcaggtgc gtcgatgtgc tcacggaatc gccccggcac 120 cgcgatctcg aggatcacca gtgccacccc ctgcagcgcg acaccgacga ttccgtacac 180 cgccacgccg atcaggccct gggccagctg gcgtatatgg cggcgatggt gacgatggcc 240 agcgccacat acattgtggc ggccagaacc acggcgttgg ggcggcggtc gatgaacact 300 aggcgacgca gatcgcccgg ggtcaacagg ttgaccatca gaaagcctgc ga 352 704 315 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 704 tttggtgcgg ccggcaatca acttcngctc ncagcggttt cccaggcggg atgtgctgtg 60 agcgccgcac caccagcgcc gacgctaagg atggaacgca cggcatcttc tgacgcgtaa 120 ccgcgttgtg atcgcgagct gaggagacgg tatgggggag ggttctcgga ggccatctgg 180 gatgttgatg tctgtcgatc ttgagccggt gcaactcgtc ggcccggacg gtacgccgac 240 ggccgaacgc cgctaccacc gtgaccttcc tgaggaaacg ctgcgttggc tctacgatat 300 gatggtggtc acccg 315 705 390 DNA Mycobacterium bovis 705 cgcccagggc cgctcccggg cgacccgacc attgctgtcg ccgcgtaacg ccatcacgga 60 tgacgcgcag ttcgtcgctg tctagctcca ccatcgcctg cacaccggcg gccaggaccc 120 attggccgtc gcactcgtag agcaggtaat cctcgtcgac ggactcggta accaccgccg 180 ccagctccgc tgccaggtcg gcggggttga caccggcggg catcgggatg gacgacgacg 240 cggtgctgac ggcgcctgtc gcgacgctga gctcggacac agctagtaaa tgtagcctaa 300 cctacttaat gggtcgcagc cccccggggt cgtcgcatgt ccaacgttgc tcgactggaa 360 gaaaatgctc gtcggggagc aaatggcacc 390 706 322 DNA Mycobacterium bovis 706 aatactcaat cttgatcggt ttccagcaac agccgatcga cggcttcgcc cagggccgct 60 cccgggcgac ccgaccattg ctgtcgccgc gtaacgccat cacggatgac gcgcagttcg 120 tcgctgtcta gctccaccat cgcctgcaca ccggcggcca ggacccattg gccgtcgcac 180 tcgtagagca ggtaatcctc gtcgacggac tcggtaacca ccgccgccag ctccgctgcc 240 aggtcggcgg ggttgacacc ggcgggcatc gggatggacg acgacgcggt gctgacggcg 300 cctgtcgcga ctctgagctc gg 322 707 398 DNA Mycobacterium bovis 707 ggatgtgctg tgagcgccgc accaccagcg ccgacgctaa ggatggaacg cacggcatct 60 tctgacgcgt aaccgcgttg tgatcgcgag ctgaggagac ggtatggggg agggttctcg 120 gaggccatct gggatgttga tgtctgtcga tcttgagccg gtgcaactcg tcggcccgga 180 cggtacgccg acggccgaac gccgctacca ccgtgacctt cctgaggaaa cgctgcgttg 240 gctctacgag atgatggtgg tcacccgcga gctggatacc gaattcgtca atctgcagcg 300 ccagggggaa gctggcgttg tacacgccct gtcgcgggca ggaagccgcg caggtgggtg 360 cggcggcttg cctacgcaaa accgactggt tgttcccc 398 708 175 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 708 atcacgacaa cagcgacggt gtgtcggatc agcggccccc gttgccgggc aatgttgagg 60 cgtttctgcg tctggttgag gccggctggg acnccgaggt ggctcgtcgg ccacatgggc 120 agcacaccac cgtggtgatg catctagacg tgcaggaccg tgccgctggc ctgca 175 709 210 DNA Mycobacterium bovis 709 gcggctacgt gccatcgaga cactggcgca ggctatcgca cccgttatcg gctgcgagca 60 aatcgcggta tgcgttcttg agcatgagtc ggcgaccgtc gtcatggtcg acacccacga 120 cggaaagacg cagatcgccg tcaagcatgt gtgccgcgga ttatcaggac tgacctcctg 180 gctgaccggc atgtttggtc gcgatgcctg 210 710 312 DNA Mycobacterium bovis 710 tacaagcggc acctcgccgg tgaactgacc gttcgcacgc tgcgcaccgc cgccgggcgc 60 gtgctcggcg cgccggcggc ccccgaggcc tgagagggga accaaccatg caggtgaaca 120 tgacggtaaa cggcgagccc gtcaccgccg aggtcgaacc ccggatgctg ctggtccatt 180 ttctccgtga tcagctgcgg ctcaccggaa ctcactgggg ctgtgatacc agcaactgcg 240 ggacatgcgt ggtggaggtc gacggcgtgc cggtgaaatc ctgcacgatg ctcgccgtga 300 tggcctccgg gc 312 711 255 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 711 agcggctggt tacgactccc tgtttgtgat ggaccacttc taccaactgc ccatgttggg 60 gacgcccgnc cntccgatgc tggaagccta cactgccctt ggtgcgctgg ccncngcgac 120 cgagcggctg caactgggcg cnttggtgac cngcaatacc taccgcaccc cnaccctgct 180 ggncaaanat catcaccacg ctcgacttgg ttagcgccgg tcgancgatc ctcggcattg 240 gaaccggttg gtttn 255 712 304 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 712 acgcgcgccg atcatatctg ctatggatgt acaattcagc tcttgctgtt ataccagtat 60 atggtgtact atttgatcta tgctgacgtg tgagatgcgg gaatcggccc tggctcgact 120 cggccgggct ctggctgatc cgacgcggtg ccggattctg gtggcgttgc tggatggcgt 180 ttgctatccc ggccagctag ctgcgcacct cgggttgacc cgatcgaatg tgtccaacca 240 tctgtcgtgt ttgcggggct gcgggctggt antcccaacc tatgagggcc ggcaggttcg 300 gtat 304 713 352 DNA Mycobacterium bovis 713 ccgcgctgct gctgacgtcg gtcgaacgtg cgacacgtct gcgaataccg gccgaacgct 60 gggtttatcc acaggctggc accgacgccc acgacacacc ggccgtcgcc gaccgccacc 120 gactgcatcg gtcgacggcc attcggatcg ccggtgcccg ggcgctggaa ctggctgggc 180 tggggctcga tgacatcgaa tacgtcgacc tgtattcgtg ctttccctcc gctgtccaag 240 tcgccgcaat cgaactcggc ctggacaccg acgatcctgc ccgcccgctg accgtcaccg 300 ggggcctgac cttcgccggc gggccgtgga gcaattacgt cacgcactcc at 352 714 233 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 714 caggcgtgca atgacctgca ctgcgccgga nantccctaa cccactaaac cggggccgct 60 cacaagccgt gcagctcggt cagcgtcagg tgcgcgacca ggaantaaat gagcagaccc 120 gtgccgtcaa cgatggtggc gatcatcggc cccgaaacga tggccgggtc natgcgcaac 180 ttcttcagca gcggcggaag gacggcancc accagcgacn accacaccac gat 233 715 335 DNA Mycobacterium bovis 715 gcgaacactt cgtcaacttc cagggctgcc cgcaccaagt atttcgacga gtatttccgt 60 cgggccgccg ccgccggcgc gcggcaggtg gtcatcctgg cggcggggct ggactcgcgc 120 gcgtaccggc tgccttggcc cgacgggacc acggtttttg agctggaccg cccgcaggtc 180 cttgatttca agcgcgaggt gctcgccagc cacggtgccc aaccgcgcgc cctgcgccgc 240 gagatcgccg tcgacctgcg tgacgattgg ccacaagcct tgcgggacag tggtttcgat 300 gcggctgcac cgtcggcatg gattgccgaa gggct 335 716 274 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 716 ttgggcnttg cccncaatan ggccccaatc aaaagccgag caggtggaac ctanncgcat 60 tcgcctcntc gtntgtgcac ccgagccatc gcacgcgcgg gaattcccgg atntcnccgt 120 attctccggc ggccgggcta acccatccca ngccgaacgg ttggctcntg ccgtgggtcc 180 cgtgttggcc gatcggggcg tcaccggggg tgctcgggtg cggntgacca tggcnaactg 240 ccccnatggg ccgaccctgg tgcagataaa cctg 274 717 327 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 717 tggtggaggt ccccaccaan acccggccgt aactctgctc acggaaatgc ggncaggccg 60 cgcgtagcac gtggtatccg ccataaaggt gcaccttaag cacggcgtcc caattctcga 120 acgacatctt gtggaaggtg ccgtcgcgca agatcccggc gttgctcacc acaccgtgca 180 cggcgccgaa ttcgtcaagc gcggtcttga tgatgttcgc tgcgccgtcc tcggtggcga 240 cgctgtcggt anttggcgac cgcccggccc cccttgtcgc gaaatctcgg cgacgacctc 300 atcggccatc gccgaaccgg gcgcccg 327 718 344 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 718 gccggccaaa ctggccggcg gggttgctgt cntcaaggtg ggttccgcca ccaanaccnc 60 actcaaggat cgcaaggaaa gcntcaagga tgcggtcgcg gccgccaagg ccgcggtcaa 120 ggagggcatc gtccctggtg ggggancctc cctcatccac caggcccgca aggcgctgac 180 cgaactgcnt gcgtcncnga ccggtgacaa ngtcctcggt gtccacgtgt nctccgaagc 240 ccttgccgct ccgttgttct ggatcnccnc caacnctggc ttggacggct cngtggtggt 300 caacaaggtc agcgagctac ccgccgggca tgggctgaac gtga 344 719 271 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 719 cgaacctnaa ttgtcctgta atgcccagct caccaangca tggctggtgg ccggggcggt 60 gaagccggcg tctgcggcac cgtccaactc natgtggatn gccggaatgg ggatgtccgg 120 nacggcgaat ccgtanttcg cttgtcccgt gaggcccagg tggatggggg gaaggatcnt 180 ggtgtccggg atgatnatgg ggccgatgcc gccggttgaa gtccactgga tcgggaattc 240 gggaatcgtg atnccgacgt tcaggccgaa c 271 720 302 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 720 ctaacggaat gaaagccctg gtggccgtnt cggcggtggc cgtcgtcgca ctgctcggtg 60 tatcttccgc ccaagctgat cccgaggcgg atcccggcgc aggtgaggcc aactatggtg 120 gccccccaag ttccccacgt cttgtcgatc acaccgaatg ggcgcantgg ggaattctgc 180 ccagcctccg ggtctacccg tcccaagttg ggcgtacanc ctcccgccgc ctcgggatgg 240 ccgctgccga cccggcctgg gccnaggttc tcgcgctgtc accggaagcc gacactgccg 300 gc 302 721 303 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 721 ccgcgggaca cncctcnatg ctgccgccat ggacgcggtc gaacgcaagc agctgatcga 60 gctacaacgc cgcgcggaac gcttccgccg cgggcgtgac cgcatcccgt tgaccgggcg 120 gatcgcggtg atcgtcgatg acggcatcgc caccggagcg acggccaagg cggcgtgcca 180 ggtcgcccgg gcgcacggtg cggacaaggt ggtgctggcg gtcccgatcg gcccanacga 240 catcgtggcg aagattcgcc gggtacgccg atgatgtggt gtgtttggcg acgccggcgt 300 tgt 303 722 280 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 722 ctctgggacc ggccacggtg ccnccggcgt tcccggacgt gctgcgccag gtgtccggcg 60 gccgcgtgca tggtgttccc ggatcggccg ctggccagag cccaccggtg aatctggcgc 120 ctggccgacc accgtgcgcc gtaggcttgc gatcgtgcag cgctggcgtg gccaggacga 180 gatcccgacg gattggggca gatgcgtgct caccatcggg gtatttgacg gcgtgcaccg 240 cgggcacgcc gaactgatcg cgcacgcggt caaaggcggc 280 723 333 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 723 aatactcaag ctttcgtcag ttcattgcgc cagcagacca acaanagcat cgggacatac 60 ggantcaact acccggccaa cggtgatttc ttggccgccg ctgacggcgc gaacgacgcc 120 agcgaccacn ttcagcaaat ggccancgcg tgccgggcca cgaggttggt gctcggcggc 180 tactcccagg gtgcggccgt gatcnacatc ntcaccgccg caccactgcc cggcctcggg 240 ttcacgcagc cgttgccgcc cgcagcggac natcacatcg ccgcgatcgc cctgttcggg 300 aatccctcng gccgcgctgg cgggctgatt aac 333 724 320 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 724 tgccgcggat ttggctggct gcccaatatt cagaatcggg cctttctttt tgcgcgacaa 60 taaggtcaca gtaaaccctc gttttgtgag atgcggggcg ggccgggcga antcgacctc 120 gagtgaatgg atctcgagtg aatggacagg gcatcgccta cgagtcgcat ccccatccaa 180 cagaccggtg ctcttgcatc ggaccctgaa ggtcccgcac ggagggtgtg gttgccggcg 240 cggggtcacg gtgcggtagc gacgtagtgt ttgaacgaat ttcttgatgc tccaacctgt 300 ttggtgttca atccagttct 320 725 296 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 725 aancttgcgc gctcggccgg gtcnagcatc cagctgctcg gcaaggaggc cagctacncn 60 tcgctgcgta tgcccagcgg tgagatccgc cgggtcnacg tccgctgccg cgcgaccgtc 120 ggcgaagtgg gcaatgccga gcaggcaaac atcaactggg gcaaggccgg tcggatgcgg 180 tggaagggca agcgcccgtc ggtccggggc gtggtgatna acccggtcna ccacccgcac 240 ggcggtggtg agggtaaaac ctccggcggc cgtcacccgg ttagcccgtg gggcaa 296 726 304 DNA Mycobacterium bovis unsure (various positions within the sequence) applicants are uncertain of bases designated as “n” 726 antcgaaagt gaccatctct accttgagtg ccataccgcc cgaccctatg cctcggatag 60 ctcggcggaa agaaacgctt gcagtgccgc cgaataggcg gctacgtcgt gagcgcccat 120 caactctcgc gcggagtgca tcgccagctg ggcggcgccg acgtcgaccg tggggattcc 180 ggtgcgcgcc gcggccaacg gcccgatcgt cgacccgcac ggcagatcgg cgcgatgttc 240 gtaacgctgc ataggcactc ccgcgcgctg gcaggccagt gcgaacgccg ccgcggtgcg 300 tccg 304 727 318 PRT Mycobacterium sp. 727 Pro Thr Gln Thr Leu Thr Gly Arg Pro Leu Ile Gly Asn Gly Thr Pro 1 5 10 15 Gly Ala Val Gly Ser Gly Ala Thr Gly Ala Pro Gly Gly Trp Leu Leu 20 25 30 Gly Asp Gly Gly Ala Gly Gly Ser Gly Ala Ala Gly Ser Gly Ala Pro 35 40 45 Gly Gly Ala Gly Gly Ala Ala Gly Leu Trp Gly Thr Gly Gly Ala Gly 50 55 60 Gly Ala Gly Gly Ser Ser Ala Gly Gly Gly Gly Ala Gly Gly Ala Gly 65 70 75 80 Gly Ala Gly Gly Trp Leu Leu Gly Asp Gly Gly Ala Gly Gly Ile Gly 85 90 95 Gly Ala Ser Thr Val Leu Gly Gly Thr Gly Gly Gly Gly Gly Val Gly 100 105 110 Gly Leu Trp Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly Thr Gly Leu 115 120 125 Val Gly Gly Asp Gly Gly Ala Gly Gly Ala Gly Gly Thr Gly Gly Leu 130 135 140 Leu Ala Gly Leu Ile Gly Ala Gly Gly Gly His Gly Gly Thr Gly Gly 145 150 155 160 Leu Ser Thr Asn Gly Asp Gly Gly Val Gly Gly Ala Gly Gly Asn Ala 165 170 175 Gly Met Leu Ala Gly Pro Gly Gly Ala Gly Gly Ala Gly Gly Asp Gly 180 185 190 Glu Asn Leu Asp Thr Gly Gly Asp Gly Gly Ala Gly Gly Ser Ala Gly 195 200 205 Leu Leu Phe Gly Ser Gly Gly Ala Gly Gly Ala Gly Gly Phe Gly Phe 210 215 220 Leu Gly Gly Asp Gly Gly Ala Gly Gly Asn Ala Gly Leu Leu Leu Ser 225 230 235 240 Ser Gly Gly Ala Gly Gly Phe Gly Gly Phe Gly Thr Ala Gly Gly Val 245 250 255 Gly Gly Ala Gly Gly Asn Ala Gly Trp Leu Gly Phe Gly Gly Ala Gly 260 265 270 Gly Val Gly Gly Ser Ala Gly Leu Ile Gly Thr Gly Gly Asn Gly Gly 275 280 285 Asn Gly Gly Thr Gly Ala Asn Ala Gly Ser Pro Gly Thr Gly Gly Ala 290 295 300 Gly Gly Leu Leu Leu Gly Gln Asn Gly Leu Asn Gly Leu Pro 305 310 315 728 334 PRT Mycobacterium sp. 728 Pro Thr Gln Thr Leu Thr Gly Arg Pro Leu Ile Gly Asn Gly Thr Pro 1 5 10 15 Gly Ala Val Gly Ser Gly Ala Thr Gly Ala Pro Gly Gly Trp Leu Leu 20 25 30 Gly Asp Gly Gly Ala Gly Gly Ser Gly Ala Ala Gly Ser Gly Ala Pro 35 40 45 Gly Gly Ala Gly Gly Ala Ala Gly Leu Trp Gly Thr Gly Gly Ala Gly 50 55 60 Gly Ile Gly Gly Ala Ser Thr Val Leu Gly Gly Thr Gly Gly Gly Gly 65 70 75 80 Gly Val Gly Gly Leu Trp Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly 85 90 95 Thr Gly Leu Val Gly Gly Asp Gly Gly Ala Gly Gly Ala Gly Gly Thr 100 105 110 Gly Gly Leu Leu Ala Gly Leu Ile Gly Ala Gly Gly Gly His Gly Gly 115 120 125 Thr Gly Gly Leu Ser Thr Asn Gly Asp Gly Gly Val Gly Gly Ala Gly 130 135 140 Gly Asn Ala Gly Met Leu Ala Gly Pro Gly Gly Ala Gly Gly Ala Gly 145 150 155 160 Gly Asp Gly Glu Asn Leu Asp Thr Gly Gly Asp Gly Gly Ala Gly Gly 165 170 175 Ser Ala Gly Leu Leu Phe Gly Ser Gly Gly Ala Gly Gly Ala Gly Gly 180 185 190 Phe Gly Phe Leu Gly Gly Asp Gly Gly Ala Gly Gly Asn Ala Gly Leu 195 200 205 Leu Leu Ser Ser Gly Gly Ala Gly Gly Phe Gly Gly Phe Gly Thr Ala 210 215 220 Gly Gly Val Gly Gly Ala Gly Gly Asn Ala Gly Trp Leu Gly Phe Gly 225 230 235 240 Ala Gly Gly Ile Gly Gly Ile Gly Gly Asn Ala Asn Gly Gly Ala Gly 245 250 255 Gly Asn Gly Gly Thr Gly Gly Gln Leu Trp Gly Ser Gly Gly Ala Gly 260 265 270 Val Glu Gly Gly Ala Ala Leu Ser Val Gly Asp Thr Gly Gly Ala Gly 275 280 285 Gly Val Gly Gly Ser Ala Gly Leu Ile Gly Thr Gly Gly Asn Gly Gly 290 295 300 Asn Gly Gly Thr Gly Ala Asn Ala Gly Ser Pro Gly Thr Gly Gly Ala 305 310 315 320 Gly Gly Leu Leu Leu Gly Gln Asn Gly Leu Asn Gly Leu Pro 325 330 729 650 DNA Mycobacterium sp. 729 gcggccgcaa ggggttcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg 60 cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat 120 gcgtaaggag aaaataccgc atcaggcgcc attcgccatt caggctgcgc aactgttggg 180 aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 240 caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 300 ccagtgaatt gtaatacgac tcactatagg gcgaattcga gctcggtacc cggggatcct 360 ctagagtcga cctgcaggca tgcaagcttg agtattctat agtgtcacct aaatagcttg 420 gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac 480 aacatacgag ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc 540 acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg 600 cattaatgaa tcggccaacg cgaacccctt gcggccgccc gggccgtcga 650 730 8 PRT Mycobacterium sp. Unsure (1-8) applicants are uncertain of residues designated as “xaa” 730 Asn Xaa Gly Xaa Gly Asn Xaa Gly 1 5 731 9 PRT Mycobacterium sp. Unsure (1-9) applicants are unsure of residues designated as “xaa” 731 Gly Xaa Xaa Ser Val Pro Xaa Xaa Trp 1 5 732 29 PRT Mycobacterium sp. 732 Gly Gly Ala Gly Gly Ala Gly Gly Ser Ser Ala Gly Gly Gly Gly Ala 1 5 10 15 Gly Gly Ala Gly Gly Ala Gly Gly Trp Leu Leu Gly Asp 20 25 733 45 PRT Mycobacterium sp. 733 Gly Ala Gly Gly Ile Gly Gly Ile Gly Gly Asn Ala Asn Gly Gly Ala 1 5 10 15 Gly Gly Asn Gly Gly Thr Gly Gly Gln Leu Trp Gly Ser Gly Gly Ala 20 25 30 Gly Val Glu Gly Gly Ala Ala Leu Ser Val Gly Asp Thr 35 40 45 734 21 DNA Mycobacterium sp. 734 agttagctca ctcattaggc a 21 735 21 DNA Mycobacterium sp. 735 ggatgtgctg caaggcgatt a 21 736 27 DNA Mycobacterium sp. 736 aaacagctat gaccatgatt acgccaa 27 737 24 DNA Mycobacterium sp. 737 tcctctagag tcgacctgca ggca 24 738 18 DNA Mycobacterium sp. variation (1-18) bases designated as “n” may be A,T,C or G 738 tctagannnn nntccggc 18 739 18 DNA Mycobacterium sp. variation (1-18) bases designated as “n” may be A, T, C or G 739 tctagannnn nngggccc 18 740 20 DNA Mycobacterium sp. variation (1-20) bases designated as “n” may be A, T, C, or G 740 cgtttaaann nnnwaggccg 20 741 21 DNA Mycobacterium sp. variation (1-21) bases designated as “n” may be A, T, C, or G 741 ggtactagtn nnnnwtccgg c 21 742 22 DNA Mycobacterium sp. 742 acgacctcat attccgaatc cc 22 743 23 DNA Mycobacterium sp. 743 gcatctgttg agtacgcact tcc 23 

What is claimed is:
 1. A purified polynucleotide consisting of SEQ ID NO:1.
 2. A purified polynucleotide, comprising SEQ ID NO:2.
 3. A purified polynucleotide, comprising SEQ ID NO:3.
 4. A purified polynucleotide comprising SEQ ID NO:4.
 5. A purified polynucleotide comprising SEQ ID NO:5. 